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Hba 09 Presentation


This is a presentation on the process of formulating customized cosmeceuticals.

This is a presentation on the process of formulating customized cosmeceuticals.

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  • 1. Custom Cosmeceutical Formulations Utilizing Medical Image Analysis and Biometric Markers Robert P. Manzo Skinprint 1997 Rt 17M Goshen, New York 10921 845-294-8501
  • 2. Background Mass Customization and Personalization is now common Automobiles Clothing Shoes Cosmeceutical Technology & Diagnostics Have Converged Skin diagnostics have become more user friendly Medical imaging has become more accessible Cosmetic active ingredients are efficacious Consumers are more educated Demographics are creating demand
  • 3. 3 Types of PigmentationCosmeceutical Customized/Personalized Formulation Imaging . High resolution macro photography Color ultraviolet reflectance A specific combination photography of biometric measurements and Epidermal Biometrics imaging will yield Hydration optimal results in most pH cases Elasticity & Firmness TEWL (Barrier) Sebum Melanin and redness
  • 4. Imaging Quantitative Markers Wrinkles Color tone Stratum corneum texture Hyper pigmentation root cause Oxidative damage Melasma Post-inflammatory hyper pigmentation Melanin banding patterns Pore size Bacterial presence (UV) Determination of epidermal vs. dermal Melasma (UV) Product occlusion Lesion count
  • 5. Subject with Melasma and minor oxidative damage (sun damage) Confidential
  • 6. Subject with Melasma and minor oxidative damage (sun damage) and melanin banding Confidential
  • 7. Bacterial presence
  • 8. Bacterial presence
  • 9. Product Occlusion Confidential
  • 10. Epidermal Biometrics Hydration Dose and type of moisturizing ingredient pH Bacterial proliferation (acne root cause) Too many chemical peels (barrier function impairment) Elasticity & Firmness Type and dose of collagen and elastin initiators Dose of MMP suppressors TEWL (Barrier) Humectant or occlusive moisturizer Acne initiator Sebum Acne root cause Melanin and redness Baseline for in office procedures (lasers, peels, etc.) Rosacea quantification Healing rates
  • 11. Case Study 46 year old subject Self described issues “spots” on face Under eye darkness and puffiness Chronic dryness Skin laxicity Medical History Healthy, non-remarkable Pre-menopausal 12 year use of Retin-A
  • 12. Visible and UVCR Analysis
  • 13. Subject Biometrics Before Treatment Reading Optimal Range •Hydration 38.0 >62 •pH 5.9 4.5 - 5.5 •Elasticity & Firmness 47.0 >60 •TEWL (Barrier) 9.0 <3 •Sebum 3.0 15 - 25 •Melanin 15 (spots = 36) 7 (spots = 22) •redness 46 17
  • 14. Treatment Course Cleanser: anionic surfactant base for thorough cleansing 3 dimensional bio-peptide approach Collagen I & III initiator Fibril bundling strengthener Matrix Metalloproteinase inhibitor Two phase eye treatment approach Capillary seal Chelant for removal of iron (hemoglobin) Three phase lightening approach MSH suppressor Tyramine competition Tyrosinase inhibitor Treatment Lotion Liposomal ursolic acid (barrier repair) Occlusive and humectant moisturizers
  • 15. Results Before After Hydration 38.0 67.0 pH 5.9 5.3 Elasticity & Firmness 47.0 56.0 TEWL (Barrier) 9.0 2.0 Sebum 3.0 4* Melanin 15 (spots = 36) 8 (spots = 25) redness 46 17 Confidential
  • 16. Results
  • 17. Results
  • 18. 1997 RT 17M Goshen, New York 10924 845-294-8501 Robert Manzo