Surveying the ELN
      Landscape
              Simon Coles
CTO & Co-Founder, Amphora Research Systems
http://www.amphora-research.com/
My blog: http://elnblog.com        2
Copies of these slides




http://www.amphora-research.com/
My blog: http://elnblog.com        2
About Amphora
               • Started in ELNs in 1996
                • Globally deployed, fully electronic ELN
         ...
Some people we work with




http://www.amphora-research.com/
Some people we work with




http://www.amphora-research.com/
What we do

               • Patent Evidence Creation & Preservation
                • Make lawyers happy
                ...
What we do

               • Sometimes our stuff is used...
                • Standalone
                • In conjunction ...
Why me?

               • We do the Patent Evidence problem
               • You still need to make the scientists happy
 ...
ELN Landscape

               • Business drivers - comparing the different
                     sectors and disciplines
  ...
Why?

               • Why do we care about the ELN landscape?
               • Because it helps us all communicate
      ...
The “ELN” Word

               • Very ambiguous
               • Probably best if you didn’t use it
               • Say w...
What do you mean?

               • The term “ELN” means different things to
                     different people
       ...
What is an ELN?
                                                   Corporate aspects
                                     ...
Patent Evidence
               • Typically this is a broad, thin layer
               • Consistently applied across the wh...
Patent Evidence
               • Typically this is a broad, thin layer
               • Consistently applied across the wh...
Industry/Company Type

               • Life Sciences
                • Biotech or Pharma
                • Biology Vs Che...
Biotech Vs Pharma
               •     Pharma tend to be much more “Mature” organisations
                   •      Everyt...
Differences that make a
                    Difference

               • There are 2 key aspects which impact the
        ...
Regulated or not?
               • If you are regulated, chances you are talking
                     about process automa...
ELNs in a Regulated
                             Area
               • The functions of a “Notebook” will often
          ...
Chemistry Vs Biology


               • In Life Sciences, the biggest distinction is
                     between Chemists...
Chemistry

               • Chemistry is pretty structured
               • Buy (or build) them a Chemistry-centric
      ...
Sources of Chemistry
                         ELNs
                • If you’re a big pharma, you’re probably
             ...
Sources of Chemistry
               • In Biotechs, you probably can’t afford to
                     build or do vendor ca...
Biology

               • Massive diversity
               • Lots of Microsoft Office and other “non
                     E...
Biology-specific ELNs
               •     There are some biology-specific ELNs
               •     Rely on the constructio...
Examples

               • Biology in Janssen (IQPC Brussels 2007)
                • Really good example of in-depth analy...
Small/Medium
                                    Chemicals
               • Lots of point solutions
               • Rarel...
Large Chemicals

               • Somewhat boring places you may or may
                     not have heard of
           ...
Large Chemicals
               • Massive diversity
               • R&D is typically very close to the customer
          ...
Large Chemicals

               • The ELN project will “Open the can of
                     worms” in terms of
          ...
General Purpose ELNs

               • “You all use the same Paper notebook don’t
                     you?”
             ...
General Purpose ELNs
               • You can do it for small numbers of users
                     and certain styles of ...
General Purpose ELNs
         Functionality




                                   Number of users
http://www.amphora-rese...
General Purpose ELNs
         Functionality




                                        Possible

                        ...
General Purpose ELNs
         Functionality

                         Possible




                                       ...
General Purpose ELNs
         Functionality

                         Possible



                                        ...
Front end tools

               • Most organisations will end up providing
                     different front ends to di...
Patents
               • As a rule, what you need to do from a
                     Patent perspective is pretty generic
 ...
Records Management

               • The Cinderella of ELN projects
               • Desperately important
               ...
Build or Buy?
               •     I don’t believe there’s one true answer here
               •     There’s a resurgence ...
Conclusions


               • Our original question
               • Some thoughts

http://www.amphora-research.com/
My b...
Our Questions

                   • What’s the differences that make a
                          difference?
             ...
Differences

               • Life Sciences Vs Everyone else
               • In Life Sciences
                • Biology V...
Beware the ELN word


               • Say what you mean
               • Expect different front ends to support
         ...
Changing the world

               • Unless you have been specifically charged
                     with changing the workfl...
Conclusions

               • They’ve probably already got what they
                     need anyway
               • Or ...
Conclusion
               • If you are charged with changing the
                     workflow
                   • That’s ...
Patent Evidence


               • Stick with best practice unless you really
                     know what you are doing...
Conclusion

               • Chemistry - buy, or build, the best you can
               • Biology - get out of their way
 ...
Thank You


               • Slides will be on our web site tonight
               • Any questions?

http://www.amphora-re...
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2010 01 27 Surveying the ELN Landscape

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My talk from SMI ELN conference looking at the ELN landscape:
• Business drivers
- Comparing the different sectors and disciplines
• Build or buy?
• An overview of the solution space
• Patterns of success

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  • The Kodak ELN was the largest ELN
    And is the oldest, fully electronic ELN around, been through a number of generations
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • This is just a sample
    50/50 split between Europe and North America
  • We’re trying to give you a map to see how all the bits fit together
  • We call this Broad Vs Deep
    Others have similar diagrams
  • This is our gig
  • Less overhead
    Sometimes don’t have any regulated activity
    You have some large Biotechs who are like Pharmas
  • Before we start, it is important to talk about some of the “Differences” that “Make a difference” in terms of how you will need to approach this.
  • So you’re really looking at just getting on with it
  • LIMS
    SDMS etc.
  • Examples of this are Incyte etc.
  • The low tolerance is a reason why you need to be careful about rolling stuff out there
  • Generally if you see a case study like this, it is a smaller company
  • 2010 01 27 Surveying the ELN Landscape

    1. 1. Surveying the ELN Landscape Simon Coles CTO & Co-Founder, Amphora Research Systems
    2. 2. http://www.amphora-research.com/ My blog: http://elnblog.com 2
    3. 3. Copies of these slides http://www.amphora-research.com/ My blog: http://elnblog.com 2
    4. 4. About Amphora • Started in ELNs in 1996 • Globally deployed, fully electronic ELN for Kodak • Grew from there... • Now work with large & small companies • Biotechs, Pharma, Chemicals http://www.amphora-research.com/ My blog: http://elnblog.com 3
    5. 5. Some people we work with http://www.amphora-research.com/
    6. 6. Some people we work with http://www.amphora-research.com/
    7. 7. What we do • Patent Evidence Creation & Preservation • Make lawyers happy • Which means you can make scientists happy http://www.amphora-research.com/ My blog: http://elnblog.com 5
    8. 8. What we do • Sometimes our stuff is used... • Standalone • In conjunction with other “ELN” products • With in house systems http://www.amphora-research.com/ My blog: http://elnblog.com 6
    9. 9. Why me? • We do the Patent Evidence problem • You still need to make the scientists happy • So we get a ring-side seat on some of these problems • We cross all the different ELN industries http://www.amphora-research.com/ My blog: http://elnblog.com 7
    10. 10. ELN Landscape • Business drivers - comparing the different sectors and disciplines • Build or buy? • An overview of the solution space • Patterns of success http://www.amphora-research.com/ My blog: http://elnblog.com 8
    11. 11. Why? • Why do we care about the ELN landscape? • Because it helps us all communicate • Perspective on the lessons learned in other areas http://www.amphora-research.com/ My blog: http://elnblog.com 9
    12. 12. The “ELN” Word • Very ambiguous • Probably best if you didn’t use it • Say what you mean http://www.amphora-research.com/ My blog: http://elnblog.com 10
    13. 13. What do you mean? • The term “ELN” means different things to different people • Somewhere the scientists will work • A Patent Evidence system (& long term record) http://www.amphora-research.com/ My blog: http://elnblog.com 11
    14. 14. What is an ELN? Corporate aspects (Records, IP protection, Sharing) Medicinal Chemistry Process Chemistry Molecular Biology Pharmacology Etc. http://www.amphora-research.com/ My blog: http://elnblog.com 12
    15. 15. Patent Evidence • Typically this is a broad, thin layer • Consistently applied across the whole company • Keep it out of the scientific systems • Single, well defined place • Under the control of Custodian http://www.amphora-research.com/ My blog: http://elnblog.com 13
    16. 16. Patent Evidence • Typically this is a broad, thin layer • Consistently applied across the whole company • Keep it out of the scientific systems • Single, well defined place • Under the control of Custodian http://www.amphora-research.com/ My blog: http://elnblog.com 13
    17. 17. Industry/Company Type • Life Sciences • Biotech or Pharma • Biology Vs Chemistry • Diverse Chemicals http://www.amphora-research.com/ My blog: http://elnblog.com 14
    18. 18. Biotech Vs Pharma • Pharma tend to be much more “Mature” organisations • Everything is done in an Enterprise Way • Often have a large amount of established code • Instincts are to buy, but have the resources to build • Biotech can be much lighter on their feet • Simpler problems • Smaller, younger organisations • Instinct is to build for competitive advantage, management often to buy http://www.amphora-research.com/ My blog: http://elnblog.com 15
    19. 19. Differences that make a Difference • There are 2 key aspects which impact the character of your ELN implementation • Regulated Vs Unregulated • Industry http://www.amphora-research.com/ My blog: http://elnblog.com 16
    20. 20. Regulated or not? • If you are regulated, chances you are talking about process automation, enforcement, and compliance • This isn’t easy, but it is • Relatively unambiguous • Fairly well mapped already http://www.amphora-research.com/ My blog: http://elnblog.com 17
    21. 21. ELNs in a Regulated Area • The functions of a “Notebook” will often be done electronically by something else • It won’t be called an “Electronic Lab Notebok” • Mixing regulated none regulated generally makes life unbearably exciting http://www.amphora-research.com/ My blog: http://elnblog.com 18
    22. 22. Chemistry Vs Biology • In Life Sciences, the biggest distinction is between Chemists and Biologists http://www.amphora-research.com/ My blog: http://elnblog.com 19
    23. 23. Chemistry • Chemistry is pretty structured • Buy (or build) them a Chemistry-centric ELN and let them get on with it • The selection process is detailed but at least the work relatively consistently http://www.amphora-research.com/ My blog: http://elnblog.com 20
    24. 24. Sources of Chemistry ELNs • If you’re a big pharma, you’re probably already set • With varying success - this isn’t easy • Solutions • Buy off the shelf • Build from what you have • Vendor capture http://www.amphora-research.com/ My blog: http://elnblog.com 21
    25. 25. Sources of Chemistry • In Biotechs, you probably can’t afford to build or do vendor capture • Unless Cheminformatics is a core strength • So you’re going to have do as much as you can with off-the-shelf (customised as needed) • Nice selection of vendors, have fun! http://www.amphora-research.com/ My blog: http://elnblog.com 22
    26. 26. Biology • Massive diversity • Lots of Microsoft Office and other “non ELN” applications • Best approach is to get out of their way http://www.amphora-research.com/ My blog: http://elnblog.com 23
    27. 27. Biology-specific ELNs • There are some biology-specific ELNs • Rely on the construction of templates for each area • Work well for very structured areas • Hard to deploy over a large area because of diversity • Quickly run into the “You’ve just made Excel harder to use” problem http://www.amphora-research.com/ My blog: http://elnblog.com 24
    28. 28. Examples • Biology in Janssen (IQPC Brussels 2007) • Really good example of in-depth analysis of process • 98% approval rate on a project that size is pretty stunning http://www.amphora-research.com/ My blog: http://elnblog.com 25
    29. 29. Small/Medium Chemicals • Lots of point solutions • Rarely have the money do to anything other than implement an off-the-shelf package in a small area • Relatively simple problem • Significant successes in certain cases http://www.amphora-research.com/ My blog: http://elnblog.com 26
    30. 30. Large Chemicals • Somewhat boring places you may or may not have heard of • But employ 1,000 of scientists and make most of the fun stuff in your house and car • e.g. companies like Kodak, BASF, PPG, Milliken, USG, etc. http://www.amphora-research.com/ My blog: http://elnblog.com 27
    31. 31. Large Chemicals • Massive diversity • R&D is typically very close to the customer • Tight timescales • Low tolerance for “non-value add” activities • Not as much “Chemistry” as you’d think http://www.amphora-research.com/ My blog: http://elnblog.com 28
    32. 32. Large Chemicals • The ELN project will “Open the can of worms” in terms of • The tools people are using • The records they are creating • The patent evidence that is generated http://www.amphora-research.com/ My blog: http://elnblog.com 29
    33. 33. General Purpose ELNs • “You all use the same Paper notebook don’t you?” • “So surely you can all use the same Electronic notebook?” http://www.amphora-research.com/ My blog: http://elnblog.com 30
    34. 34. General Purpose ELNs • You can do it for small numbers of users and certain styles of work • Where workflow is important • For large numbers of users • The diversity in process will kill you • You end up building an expensive version of Word & Excel http://www.amphora-research.com/ My blog: http://elnblog.com 31
    35. 35. General Purpose ELNs Functionality Number of users http://www.amphora-research.com/ My blog: http://elnblog.com 32
    36. 36. General Purpose ELNs Functionality Possible Number of users http://www.amphora-research.com/ My blog: http://elnblog.com 32
    37. 37. General Purpose ELNs Functionality Possible Possible Number of users http://www.amphora-research.com/ My blog: http://elnblog.com 32
    38. 38. General Purpose ELNs Functionality Possible Doomed to fail The organisation will frustrate you Possible Number of users http://www.amphora-research.com/ My blog: http://elnblog.com 32
    39. 39. Front end tools • Most organisations will end up providing different front ends to different users • Examples • BMS, Solvay, J&J, BASF, all the other large companies http://www.amphora-research.com/ My blog: http://elnblog.com 33
    40. 40. Patents • As a rule, what you need to do from a Patent perspective is pretty generic • You might have some specific needs, but 95% of what you need can be done off the shelf • This is one area where you want to stick with best practice and leave it alone http://www.amphora-research.com/ My blog: http://elnblog.com 34
    41. 41. Records Management • The Cinderella of ELN projects • Desperately important • Clearly something that’s dependent on your own processes http://www.amphora-research.com/ My blog: http://elnblog.com 35
    42. 42. Build or Buy? • I don’t believe there’s one true answer here • There’s a resurgence in components to allow a “Build” decision • e.g. Cheminformatics as a service • Decision will be down to • Internal capabilities • Degree of specialisation • Ultimately all project teams will be constructing an “ELN System” from components – whether they are called “ELN”s, or other lower-level parts http://www.amphora-research.com/ My blog: http://elnblog.com 36
    43. 43. Conclusions • Our original question • Some thoughts http://www.amphora-research.com/ My blog: http://elnblog.com 37
    44. 44. Our Questions • What’s the differences that make a difference? • What simple things can you do to increase your chance of success? http://www.amphora-research.com/ My blog: http://elnblog.com 38
    45. 45. Differences • Life Sciences Vs Everyone else • In Life Sciences • Biology Vs Chemistry • Biotech-ish Vs Pharma-ish • Regulated or not? http://www.amphora-research.com/ My blog: http://elnblog.com 39
    46. 46. Beware the ELN word • Say what you mean • Expect different front ends to support different work http://www.amphora-research.com/ My blog: http://elnblog.com 40
    47. 47. Changing the world • Unless you have been specifically charged with changing the workflow • Don’t pick the fight • You’re there to support the science • Today and in the future http://www.amphora-research.com/ My blog: http://elnblog.com 41
    48. 48. Conclusions • They’ve probably already got what they need anyway • Or a very good idea of what they need • That’s why they asked for an ELN in the first place http://www.amphora-research.com/ My blog: http://elnblog.com 42
    49. 49. Conclusion • If you are charged with changing the workflow • That’s your project, not “ELN” or whatever • Try to keep the scope as small as possible • Size and diversity will kill you http://www.amphora-research.com/ My blog: http://elnblog.com 43
    50. 50. Patent Evidence • Stick with best practice unless you really know what you are doing • One single system http://www.amphora-research.com/ My blog: http://elnblog.com 44
    51. 51. Conclusion • Chemistry - buy, or build, the best you can • Biology - get out of their way • Large chemicals - you’ll never fully understand everything in detail http://www.amphora-research.com/ My blog: http://elnblog.com 45
    52. 52. Thank You • Slides will be on our web site tonight • Any questions? http://www.amphora-research.com/ My blog: http://elnblog.com 46

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