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2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
2008 04 01 ELNs, Chemistry, Biology
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2008 04 01 ELNs, Chemistry, Biology

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Looking at Chemistry and Biology ELNs

Looking at Chemistry and Biology ELNs

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  • 1. Chemistry Vs Biology Simon Coles CTO & Co-Founder, Amphora Research Systems
  • 2. Copies of these slides http://www.amphora-research.com/ 2
  • 3. About Amphora • Started in ELNs in 1996 • Globally deployed, fully electronic ELN for Kodak • Grew from there... • Now work with large & small companies • Biotechs, Pharma, Chemicals http://www.amphora-research.com/ 3
  • 4. Some of our Customers 4
  • 5. Industry http://www.amphora-research.com/ 5
  • 6. What we do • Patent Evidence Creation & Preservation • Make lawyers happy • Which means you can make scientists happy http://www.amphora-research.com/ 6
  • 7. What we do • Sometimes our stuff is used... • Standalone • In conjunction with other “ELN” products • With in house systems http://www.amphora-research.com/ 7
  • 8. Why me? • We do the Patent Evidence problem • You still need to make the scientists happy • So we get a ring-side seat on some of these problems • We cross all the different ELN industries http://www.amphora-research.com/ 8
  • 9. Audience Survey • Do you have a Med. Chem ELN project (in progress or complete?) • Do you have other kinds of scientists? • Are you deploying into • A regulated environment • A discovery environment http://www.amphora-research.com/ 9
  • 10. The Typical ELN journey (In two Acts) http://www.amphora-research.com/ 10
  • 11. Act I • Chemists are the most vocal, and can demonstrate some kind ROI • And you can buy one! From multiple vendors! • Let’s do that then... I’m sure once we’ve done that we can re-use it for our other scientists • Because they all use notebooks, right? http://www.amphora-research.com/ 11
  • 12. Meanwhile... Everyone else is getting on with business http://www.amphora-research.com/ 12
  • 13. Act II • Happy chemists • Generally, band-aided the Patent problem • Now, we’ve got an ELN • The rest of them want one too • So given we’ve already got one • Easy decision? http://www.amphora-research.com/ 13
  • 14. Typical Reactions • “We don’t work like that” • “I doesn’t work with our applications” • “Why should we bother” • “Very Expensive” • “You’ve made Excel harder to use” http://www.amphora-research.com/ 14
  • 15. What’s going on? http://www.amphora-research.com/ 15
  • 16. Why an ELN? • Because the existing solution sucks • Cut & Stick computer printouts • Can’t search (like Google) http://www.amphora-research.com/ 16
  • 17. Why an ELN? • “Easily use computer applications in the course of our work” • “Search our work” • “See other people’s work” • “If our discipline does special stuff, deal with that” http://www.amphora-research.com/ 17
  • 18. The “special stuff” • Organic Chemistry has a clear, widely-used notation which rewards specific support • There’s a Cheminformatics industry! • Other disciplines do too • But they’re much more specialised • Can often be represented as text of graphics http://www.amphora-research.com/ 18
  • 19. What they didn’t say • “Replace the applications I use day-to-day” • In fact, they want an ELN to make using those easier! • “Make my life more complex” • “Give me stuff I don’t need” http://www.amphora-research.com/ 19
  • 20. The result • Chemistry-centric ELNs don’t tend to be well received outside of Chemistry • Frustrating for involved http://www.amphora-research.com/ 20
  • 21. Note • Science is very broad • I am generalising • Your mileage may vary • I’m just trying to help people think http://www.amphora-research.com/ 21
  • 22. Science is huge http://www.amphora-research.com/ 22
  • 23. Different Styles • Chemistry tends to be pretty structured and routine • Other disciplines have much greater variation in the work http://www.amphora-research.com/ 23
  • 24. Tools • Chemistry tends to focus on the structures, reactions, properties, drawing & animating them etc. • Other disciplines have a much wider set of tools • And use Excel as a “Swiss Army Knife” • Scientists are knowledge workers too http://www.amphora-research.com/ 24
  • 25. Less is more From http://headrush.typepad.com/creating_passionate_users/2006/week30/index.html
  • 26. Part of the problem is the term “ELN” http://www.amphora-research.com/ 26
  • 27. Questions • If the paper notebook didn’t exist would we coin the term “Electronic” notebook? • If it wasn’t for the term “ELN” would we look for one system? • Why are all the “ELN” vendors (outside of chemistry) so different? • Where are the non-chemistry ELNs? http://www.amphora-research.com/ 27
  • 28. Where do they work? • Excel • Blogging tools (e.g. Wordpress) • Word • In-house experiment • Filemaker planning tools • InfoPath/SharePoint • Lotus Notes • ISIS/Draw • OneNote • Wikis • LIMS • ERP
  • 29. What are they doing? • Experiments - just like everyone else • Just because they aren’t working in a product with “ELN” stamped on it, doesn’t mean it isn’t proper science http://www.amphora-research.com/ 29
  • 30. As a rule, it is much better if you pay attention to each discipline individually http://www.amphora-research.com/ 30
  • 31. The “One System” death magnet http://www.amphora-research.com/ 31
  • 32. One System • “You all use the same Paper notebook don’t you?” • “So surely you can all use the same Electronic notebook?” http://www.amphora-research.com/ 32
  • 33. One solution? User quote: Anyone who claims one solution solves all problems... ...is a salesman http://www.amphora-research.com/ 33
  • 34. Do you need one solution? • Not unless you buy something crazily proprietary • In which case you probably don’t want it anyway • Integration is a fact of life http://www.amphora-research.com/ 34
  • 35. Can you buy One Solution? • Yes, if you only do one kind of science • Yes, if you are prepared to do an awful lot of customisation • Yes, if architecture is more important than users • Yes if you will never change what you do http://www.amphora-research.com/ 35
  • 36. General Purpose ELNs • You can do it for small numbers of users and certain styles of work • Where workflow is important • For large numbers of users • The diversity in process will kill you • You end up building an expensive version of Word & Excel http://www.amphora-research.com/ 36
  • 37. General Purpose ELNs Functionality Possible Doomed to fail The organisation will frustrate you Possible Number of users http://www.amphora-research.com/ 37
  • 38. Some Suggestions http://www.amphora-research.com/ 38
  • 39. Project Structure • Divide your problem into • Corporate aspects • Different disciples • Solve the corporate stuff centrally • Let the different user groups do what they need to do • Encourage/enforce collaboration http://www.amphora-research.com/ 39
  • 40. Medicinal Chemistry Process Chemistry Molecular Biology Pharmacology (Records, IP protection, Sharing) Corporate aspects Etc. A framework
  • 41. Patent Evidence • Typically this is a broad, thin layer • Consistently applied across the whole company • Keep it out of the scientific systems • Single, well defined place • Under the control of Custodian http://www.amphora-research.com/ 41
  • 42. Records Management • The Cinderella of ELN projects • Desperately important • Clearly something that’s dependent on your own processes http://www.amphora-research.com/ 42
  • 43. The “Deep” systems • If they use structures, they’ll probably want one of the Chemistry-centric ELNs • If they aren’t look at what they have already • You might be able to leave them alone • Just give them something to keep the lawyers happy • This will hopefully be low-impact http://www.amphora-research.com/ 43
  • 44. “Deep Systems” • More than one group might find the same system acceptable - great! • You might want tools from Rescentris, IDBS, Klee etc. to support specific aspects of their work http://www.amphora-research.com/ 44
  • 45. “Deep Systems” • If you do a good job • Everyone gets their ideal work environment • You disrupt them as little as possible • You’ve left the door open for future improvements http://www.amphora-research.com/ 45
  • 46. Sources of solutions http://www.amphora-research.com/ 46
  • 47. Chemistry • Chemistry is pretty structured • Buy (or build) them a Chemistry-centric ELN and let them get on with it • The selection process is detailed but at least the work relatively consistently http://www.amphora-research.com/ 47
  • 48. Sources of Chemistry ELNs • If you’re a big pharma, you’re probably already set • With varying success - this isn’t easy • Solutions • Buy off the shelf • Build from what you have • Vendor capture http://www.amphora-research.com/ 48
  • 49. Sources of Chemistry • In Biotechs, you probably can’t afford to build or do vendor capture • Unless Cheminformatics is a core strength • So you’re going to have do as much as you can with off-the-shelf (customised as needed) • Nice selection of vendors, have fun! http://www.amphora-research.com/ 49
  • 50. Biology • Massive diversity • Lots of Microsoft Office and other “non ELN” applications • Best approach is to get out of their way http://www.amphora-research.com/ 50
  • 51. Example • Biology in Janssen (J&J) (IQPC Brussels 2007) • Really good example of in-depth analysis of process • 98% approval rate on a project that size is pretty stunning http://www.amphora-research.com/ 51
  • 52. Some questions you might ask... http://www.amphora-research.com/ 52
  • 53. What about GxP • The needs of GxP & 21CFR11 mandate record keeping at the activity level • You can’t do this Broad Vs Deep model • I’m not sure there’s such a thing as a Generic ELN for regulated areas http://www.amphora-research.com/ 53
  • 54. What about Raw Data? • ELN isn’t the place for raw data • From a records aspect • From a practical aspect • ELN can provide metadata • But store it somewhere else (filesystems are nice!) http://www.amphora-research.com/ 54
  • 55. Patent Reform • The US will never move away from a need to prove invention (that pesky constitution) • Paradoxically, the current versions of Patent Reform will lead other Patent jurisdictions to require Notebooks too! http://www.amphora-research.com/ 55
  • 56. Isn’t this expensive? • Not if you’ve already got perfectly acceptable solutions already • The ROI on software you don’t have to buy is outstanding! http://www.amphora-research.com/ 56
  • 57. Are you on Drugs? • A large number of end-user companies have similar approaches • Most of the case studies are “Deep” systems • Ultimately, this is a much-simplified version of the CENSA architecture http://www.amphora-research.com/ 57
  • 58. Benefits of taking a Broad & Deep approach http://www.amphora-research.com/ 58
  • 59. You get to be a hero/heroine http://www.amphora-research.com/ 59
  • 60. Finding the money is easier http://www.amphora-research.com/ 60
  • 61. Training is easier/non- existent http://www.amphora-research.com/ 61
  • 62. You have a balanced relationship with your vendors http://www.amphora-research.com/ 62
  • 63. You can roll out in phases http://www.amphora-research.com/ 63
  • 64. Your lawyers won’t dictate what you do http://www.amphora-research.com/ 64
  • 65. …Thank You… • Slides will be on our web site tonight • Any questions? http://www.amphora-research.com/ 65

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