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2008 03 11 ELNs in different industries

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Looking at ELNs in different industries, which is a very unexplored area. Typically case studies are taken at face value, but you really need to understand the specifics of each situation to really …

Looking at ELNs in different industries, which is a very unexplored area. Typically case studies are taken at face value, but you really need to understand the specifics of each situation to really understand the relevance to any particular circumstance.

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  • 1. Lessons from Different Industries Simon Coles CTO & Co-Founder, Amphora Research Systems
  • 2. http://www.amphora-research.com/ 2
  • 3. Copies of these slides http://www.amphora-research.com/ 2
  • 4. About Amphora • Started in ELNs in 1996 • Globally deployed, fully electronic ELN for Kodak • Grew from there... • Now work with large & small companies • Biotechs, Pharma, Chemicals http://www.amphora-research.com/ 3
  • 5. Who we work with 4
  • 6. Who we work with 4
  • 7. Industry http://www.amphora-research.com/ 5
  • 8. What we do • Patent Evidence Creation & Preservation • Make lawyers happy • Which means you can make scientists happy http://www.amphora-research.com/ 6
  • 9. What we do • Sometimes our stuff is used... • Standalone • In conjunction with other “ELN” products • With in house systems http://www.amphora-research.com/ 7
  • 10. Why me? • We do the Patent Evidence problem • You still need to make the scientists happy • So we get a ring-side seat on some of these problems • We cross all the different ELN industries http://www.amphora-research.com/ 8
  • 11. This Presentation • Adapted from an all-day workshop given every year at the Association for Lab Automation in Palm Springs • Come and join us! • Hot, Sunny, and informative... http://www.amphora-research.com/ 9
  • 12. So… • You’ve been asked to get an ELN • You turn up to different conferences and hear different case studies • How do you know what’s applicable to you or not? • How can you increase your chances of success? http://www.amphora-research.com/ 10
  • 13. The “ELN” Word • Very ambiguous • Probably best if you didn’t use it • Say what you mean http://www.amphora-research.com/ 11
  • 14. What do you mean? • The term “ELN” means different things to different people • Somewhere the scientists will work • A Patent Evidence system (& long term record) http://www.amphora-research.com/ 12
  • 15. What is an ELN? Corporate aspects (Records, IP protection, Sharing) Medicinal Chemistry Process Chemistry Molecular Biology Pharmacology Etc. http://www.amphora-research.com/ 13
  • 16. Patent Evidence • Typically this is a broad, thin layer • Consistently applied across the whole company • Keep it out of the scientific systems • Single, well defined place • Under the control of Custodian http://www.amphora-research.com/ 14
  • 17. Patent Evidence • Typically this is a broad, thin layer • Consistently applied across the whole company • Keep it out of the scientific systems • Single, well defined place • Under the control of Custodian http://www.amphora-research.com/ 14
  • 18. Industry/Company Type • Life Sciences • Biotech or Pharma • Biology Vs Chemistry • Diverse Chemicals http://www.amphora-research.com/ 15
  • 19. Biotech Vs Pharma • Pharma tend to be much more “Mature” organisations • Everything is done in an Enterprise Way • Biotech can be much lighter on their feet • Simpler problems • Smaller, younger organisations http://www.amphora-research.com/ 16
  • 20. Differences that make a Difference • There are 2 key aspects which impact the character of your ELN implementation • Regulated Vs Unregulated • Industry http://www.amphora-research.com/ 17
  • 21. Regulated or not? • If you are regulated, chances you are talking about process automation, enforcement, and compliance • This isn’t easy, but it is • Relatively unambiguous • Fairly well mapped already http://www.amphora-research.com/ 18
  • 22. ELNs in a Regulated Area • The functions of a “Notebook” will often be done electronically by something else • It won’t be called an “Electronic Lab Notebok” • Mixing regulated none regulated generally makes life unbearably exciting http://www.amphora-research.com/ 19
  • 23. Chemistry Vs Biology • In Life Sciences, the biggest distinction is between Chemists and Biologists http://www.amphora-research.com/ 20
  • 24. Chemistry • Chemistry is pretty structured • Buy (or build) them a Chemistry-centric ELN and let them get on with it • The selection process is detailed but at least the work relatively consistently http://www.amphora-research.com/ 21
  • 25. Sources of Chemistry ELNs • If you’re a big pharma, you’re probably already set • With varying success - this isn’t easy • Solutions • Buy off the shelf • Build from what you have • Vendor capture http://www.amphora-research.com/ 22
  • 26. Sources of Chemistry • In Biotechs, you probably can’t afford to build or do vendor capture • Unless Cheminformatics is a core strength • So you’re going to have do as much as you can with off-the-shelf (customised as needed) • Nice selection of vendors, have fun! http://www.amphora-research.com/ 23
  • 27. Biology • Massive diversity • Lots of Microsoft Office and other “non ELN” applications • Best approach is to get out of their way http://www.amphora-research.com/ 24
  • 28. Examples • Biology in Janssen (IQPC Brussels 2007) • Really good example of in-depth analysis of process • 98% approval rate on a project that size is pretty stunning http://www.amphora-research.com/ 25
  • 29. Small/Medium Chemicals • Lots of point solutions • Rarely have the money do to anything other than implement an off-the-shelf package in a small area • Relatively simple problem • Significant successes in certain cases http://www.amphora-research.com/ 26
  • 30. Large Chemicals • Somewhat boring places you may or may not have heard of • But employ 1,000 of scientists and make most of the fun stuff in your house and car • e.g. companies like Kodak, BASF, PPG, Milliken, USG, etc. http://www.amphora-research.com/ 27
  • 31. Large Chemicals • Massive diversity • R&D is typically very close to the customer • Tight timescales • Low tolerance for “non-value add” activities • Not as much “Chemistry” as you’d think http://www.amphora-research.com/ 28
  • 32. Large Chemicals • The ELN project will “Open the can of worms” in terms of • The tools people are using • The records they are creating • The patent evidence that is generated http://www.amphora-research.com/ 29
  • 33. General Purpose ELNs • “You all use the same Paper notebook don’t you?” • “So surely you can all use the same Electronic notebook?” http://www.amphora-research.com/ 30
  • 34. General Purpose ELNs • You can do it for small numbers of users and certain styles of work • Where workflow is important • For large numbers of users • The diversity in process will kill you • You end up building an expensive version of Word & Excel http://www.amphora-research.com/ 31
  • 35. General Purpose ELNs Functionality Number of users http://www.amphora-research.com/ 32
  • 36. General Purpose ELNs Functionality Possible Number of users http://www.amphora-research.com/ 32
  • 37. General Purpose ELNs Functionality Possible Possible Number of users http://www.amphora-research.com/ 32
  • 38. General Purpose ELNs Functionality Possible Doomed to fail The organisation will frustrate you Possible Number of users http://www.amphora-research.com/ 32
  • 39. Front end tools • Most organisations will end up providing different front ends to different users • Examples • BMS, Solvay, J&J, BASF, all the other large companies http://www.amphora-research.com/ 33
  • 40. Patents • As a rule, what you need to do from a Patent perspective is pretty generic • You might have some specific needs, but 95% of what you need can be done off the shelf • This is one area where you want to stick with convention http://www.amphora-research.com/ 34
  • 41. Security • In Life Sciences things are relatively sane • In Large Chemicals, you get all the fun of “Chinese Walls” created by Commercial agreements http://www.amphora-research.com/ 35
  • 42. Security • This is another whole can of worms • That didn’t really exist until the ELN came along • No one could find anything in the paper notebook anyway http://www.amphora-research.com/ 36
  • 43. Security • Ultimately you have to do what the organisation requires • But you need to avoid massively complex regimes • If you do NDA-related Chinese walls, you need to have that tagged into the record at creation http://www.amphora-research.com/ 37
  • 44. Security • The security problem isn’t a technical one • Most “Security” regimes are quite easy to implement • But often organisations aren’t wired up the right way • e.g. who keeps the list of projects and who can read what? http://www.amphora-research.com/ 38
  • 45. Records Management • The Cinderella of ELN projects • Desperately important • Clearly something that’s dependent on your own processes http://www.amphora-research.com/ 39
  • 46. Conclusions • Our original question • Some thoughts http://www.amphora-research.com/ 40
  • 47. Our Questions • What’s the differences that make a difference? • What simple things can you do to increase your chance of success? http://www.amphora-research.com/ 41
  • 48. Differences • Life Sciences Vs Everyone else • In Life Sciences • Biology Vs Chemistry • Biotech-ish Vs Pharma-ish • Regulated or not? http://www.amphora-research.com/ 42
  • 49. Beware the ELN word • Say what you mean • Expect different front ends to support different work http://www.amphora-research.com/ 43
  • 50. Changing the world • Unless you have been specifically charged with changing the workflow • Don’t pick the fight • You’re there to support the science • Today and in the future http://www.amphora-research.com/ 44
  • 51. Conclusions • They’ve probably already got what they need anyway • Or a very good idea of what they need • That’s why they asked for an ELN in the first place http://www.amphora-research.com/ 45
  • 52. Conclusion • If you are charged with changing the workflow • That’s your project, not “ELN” or whatever • Try to keep the scope as small as possible • Size and diversity will kill you http://www.amphora-research.com/ 46
  • 53. Patent Evidence • Stick with best practice unless you really know what you are doing • One single system http://www.amphora-research.com/ 47
  • 54. Security • Do what you have to do • But try to keep it simple • It isn’t a technical problem, really • But joining the dots internally can be interesting http://www.amphora-research.com/ 48
  • 55. Conclusion • Chemistry - buy, or build, the best you can • Biology - get out of their way • Large chemicals - you’ll never fully understand everything in detail http://www.amphora-research.com/ 49
  • 56. Thank You • Slides will be on our web site tonight • Any questions? http://www.amphora-research.com/ 50