CAPON Association with adjusted QT interval Results of a genome wide association study in KORA S4 and 2 replication cohorts n n KORA S4 3366 4.9 msec 36% < 10 -7 Cohort N Effect MAF Adjusted p KORA F3 2646 7.9 msec 36% < 10 -11 FHS 1805 4.0 msec 39% 0.004 Arking DE, Pfeufer A, Post W et al. Nature Genetics ; published online Apr 30 2006. *QT- adjusted for age, gender and heart rate
From the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Mass (W.S.P., M.G.L., R.H.M., M.G., D.L.); the Division of Cardiology, Beth Israel Hospital, Boston, Mass (D.L.); the Department of Neurology (R.H.M.), Division of Epidemiology and Preventive Medicine (M.G.L., D.L.), Boston University School of Medicine; the National Heart, Lung, and Blood Institute, Bethesda, Md (D.L.), University of Naples, Italy (M.G.); and the Division of Cardiology, Johns Hopkins Hospital, Baltimore, Md (W.S.P.).