UNIVERSITY OF ROCHESTER
                           SCHOOL OF MEDICINE AND DENTISTRY

                               Jun-ic...
Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
                                                                                  Curr...
Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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Jun-ichi Abe, M.D., Ph.D., F.A.H.A.
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  1. 1. UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae PERSONAL INFORMATION: Jun-ichi Abe 48 Bromley Road Pittsford, NY 14534 Home: (585) 248-5123 Work: (585) 276-9794 Fax: (585) 276-9830 E-Mail: jun-ichi_abe@urmc.rochester.edu Date of Birth: November 9, 1961 Place of Birth: Yokosuka, Kanagawa, Japan Citizenship: Japan EDUCATION: University of Yamagata, Yamagata, Japan M.D. 1987 Medicine University of Tokyo, Tokyo, Japan Ph.D. 1998 Medicine/Cardiology MILITARY SERVICE: N/A POSTDOCTORAL TRAINING: 1987-1989 Resident in Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan 1989-1992 Fellow in Internal Medicine and Cardiology, Mitsui Memorial Hospital, Tokyo, Japan 1992-1994 Instructor, Internal Medicine and Cardiology, First Department of Internal Medicine, University of Tokyo, Japan 1995-1998 Senior fellow, University of Washington, Division of Cardiology, Seattle, WA LICENSURE INFORMATION: N/A FELLOWSHIP AWARDS: 1995 Yamanouchi Foundation for Research on Metabolic Disorders 1995 Bayer and Japan Heard Foundation Award 1999-00 and 2000-01 Buswell Fellowship, University of Rochester FACULTY APPOINTMENTS: 1992-1994 Instructor, Internal Medicine and Cardiology, First Department of Internal Medicine, University of Tokyo, Japan 1998-1998 Acting Instructor, University of Washington, Division of Cardiology, Seattle, WA 1999-2003 Assistant Professor, University of Rochester, Center for Cardiovascular Research, NY
  2. 2. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 2003-present Associate Professor, University of Rochester, Aab Cardiovascular Research Institute, NY PROFESSIONAL HOSPITAL AND ADMINISTRATIVE APPOINTMENTS: 1987-1991 Physician, Mitsui Memorial Hospital, Tokyo, Japan 1991-1995 Physician, First Department of Internal Medicine, University of Tokyo Hospital, Tokyo, Japan MEMBERSHIPS IN LOCAL AND STATE ACADEMIC AND PROFESSIONAL ORGANIZATIONS: N/A MEMBERSHIPS IN NATIONAL AND INTERNATIONAL ACADEMIC PROFESSIONAL ORGANIZATIONS: 1987 Member, Japanese Society of Internal Medicine 1989 Member, Japanese Circulation Society 1989 Member, Japanese College of Cardiology 1993 Member, Japanese Society of Hypertension 1994 Member, Japanese Cancer Association 1999- Member, North American Vascular Biology Organization (NAVBO) 2000- Member, Basic Cardiovascular Science, AHA 2004- Fellow of the American Heart Association and the Council on Basic Cardiovascular Sciences 2006- Member, FASEB, American Society for Biochemistry & Molecular Biology 2009- Member, International Society for Heart Research (ISHR) LECTURESHIPS AND VISITING PROFESSORSHIPS: 1. Shear stress inhibits TNF-α induced JNK activation via protein-tyrosine phosphatase SHP-2; possible role of MEK5/BMK. Inviting lecture at the Second Aso International Meeting (AIM), Kumamoto, Japan, May 10-12, 2001. 2. Oxidative stress in cardiovascular disease. Inviting lecture at University of Yamagata, Yamagata, Japan, April 10, 2001 3. The role of cell signaling in cardiovascular damage. Inviting lectures at Yokohama (Yokohama City University, Kitazato University, and Tokai University), Yokohama, Kanagawa, Japan, June 29, 2002 The role of cell signaling in cardiovascular damage. Inviting lectures at Japan Labour Health and Welfare Organization Yokohama Rosai Hospital, Yokohama, Kanagawa, Japan, July 1, 2002 4. Endothelial inflammation: Role of MAP kinases and NF-κB. Inviting lecture at Vanderbilt University School of Medicine, Nashville, TN, July 29, 2002 5. BMK1/ERK5 prevents myocardial intracellular calcium overload and contractile dysfunction after ischemia by disrupting connexin 43 gap junctional communication. Inviting lecture at “New Wave” conference. Chicago, IL, November 18, 2002 6. Kinases and Cardiovascular Disease: From Bench to Bed side. Inviting lecture at Morehouse, Atlanta, Georgia, February 21, 2006. 2
  3. 3. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 7. Kinases and Cardiovascular Disease: From Bench to Bed side. CVRI Seminar Series, URMC. March 1, 2006. 8. Diabetes and Heart: Department of Medicine, Seminar Series, URMC. Oct.11, 2006. 9. ERK5 in diabetes: To be or not to be a kinase? Inviting lecture at Yamgata University School of Medicine, Yamgata, Japan, Sep 20, 2007. 10. ERK5 in diabetes: To be or not to be a kinase? Inviting lecture at Chiba University School of Medicine, Chiba, Japan, Sep 25, 2007. 11. ERK5 in diabetes: To be or not to be a kinase? Inviting lecture at Tokushima University School of Medicine, Tokushima, Japan, Oct 1, 2007. 12. SUMO-dependent regulation of ERK family kinase in atherosclerosis. Inviting lecture at American Heart Association Scientific Sessions, New Orleans, Nov 9, 2008 13. Regulation of shear stress induced anti-inflammatory responses. Inviting lecture at American Heart Association Scientific Sessions, New Orleans, Nov 11, 2008 MEMBERSHIPS IN LOCAL AND STATE COMMUNITY SERVICE ORGANIZATIONS: 2004- Member of Institutional Biosafety Committee HONORS AND AWARDS: 1994 Tokyo Medical Association, Prize in Research 1995 Bayer and Japan Heart Foundation Award 1995 Yamanouchi Foundation for Research on Metabolic Disorders 1999 Buswell fellowship 2000 Buswell fellowship 2007 Excellence in Research Award, University of Rochester 2007 AHA Established Investigator Award 3
  4. 4. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 A. EDUCATIONAL CONTRIBUTION OF THE LAST FIVE YEARS: 1. Medical Students. N/A 2. Graduate Students: Seminars series 2005- Pathology and Pathways of Human Disease (PTH510) 2006- Co-Director, CVRI graduate students course (CVS401), Cardiovascular Biology and Disease Graduate students Scott J. Cameron (2000-2002). Advisor and Member, Thesis Committee. Advised and mentored on his project regarding the assay of BMK1 and determination of the phosphorylation sties of BMK1 on Connexin 43. Qinlei Zheng (2002 - 2005). Member, Thesis Committee. Advised on her project about the role of 14-3-3 on BMK1 activation. Xinchun Pi (2003 - 2005). Advised on her project about the role of BMK1 activation on HIF-1 transcriptional activity. Jennifer Hom (2004- ). Member, Thesis Committee. Advised on her project about the analysis of signal transduction. Shaozhen Xie (2006-2007 ), Member, Thesis Committee. Advised on his project about the role of TR4 on atherosclerosis formation. Fatbardha Varfai (2007). Chair, Thesis Committee. Emily A. Oestreich (2007). Chair, Thesis Committee. Alon Mantel (2007-). Member, Thesis Committee. Shi Xi (2006-2008). Member, Thesis Committee. Advised on her project about the role of p90RSK on cardiac remodeling after myocardial infarction. Marlene Mathews (2008) Chair, Thesis Committee Eugene Chang (2007-), Advisor. Mentored on his project regarding the role of p90RSK on ERK5- SUMOylation and mitochondrial function. 3. Residents: N/A 4. Postdoctoral Fellows: Qunhua Huang (1999-2003) Supervised and taught cell biology and molecular biology Wenyi Che (2000 -2005) Supervised and taught cell biology and generation of transgenic mice. 4
  5. 5. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 Changxi Zhang (2000-2001). Supervised and taught cardiovascular physiology (Langendorff), biochemistry and molecular biology. Shinsuke Ohta (2000-2001) Taught biochemistry and genotyping of transgenic mice. Christopher P. Baines (1999-2000). Taught generation and handling of transgenic mice. Seigo Itoh (2000 -2005). Supervised and taught cell biology and generation of transgenic mice. AHA Postdoctoral fellowship awardee AHA postdoctoral fellowship award 0325769T 7/1/2003-6/30/2005 Principal Investigator: Itoh $76,000 Role of p90RSK and renin-angiotensin system in ischemic myocardium The project will investigate whether renin-angiotensin system activation induced by p90RSK-mediated up-regulation of pro-renin converting enzyme contributes to Ca2+ overload and mitochondrial dysfunction. Role: Mentor. Masashi Akaike (2002-2003). Supervised and taught cell biology and molecular biology. Masaki Osawa (2002-2003). Supervised and taught cell biology and molecular biology. Bo Ding (2001 - 2007). Supervised and taught molecular and cellular biology and generation of transgenic mice. Tetsuro Shishido (2005-2007) Supervised and taught molecular and cellular biology and generation of transgenic mice. Chang-Hoon Woo (2005-2009) Supervised and taught molecular and cellular biology and generation of transgenic mice. AHA Postdoctoral fellowship awardee AHA postdoctoral fellowship award 0625957T 7/1/2006-6/30/2008 Principal Investigator: Woo $76,000 The role of ERK5-SUMOylation on hyperglycemia-mediated endothelial inflammation The project will investigate whether ERK5-SUMOylation induced by high glucose is a “key” modulator of ERK5 activity and enhances endothelial inflammation by reducing shear stress-mediated ERK5- SUMOylation. Role: Mentor. Zhibo Lu (2005-2008). Supervise and teach cell biology and molecular biology. Gwenaele Garin (2005-2007). Supervised and taught cell biology and molecular biology. Kimio Saito (2006-2008). Supervise and teach cell biology and molecular biology. Cameron World (2006-). Supervise and teach cell biology and molecular biology. Lingli Li (2006-2008). Supervise and teach cell biology and molecular biology. 5. Mentoring of Faculties (KO8 and equivalent awardees) 5
  6. 6. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 Jeffery Allexis (2004-), Assistant Professor. Mentor and teach molecular and cellular biology. 5 K01 HL080938 8/1/05-7/31/10 Principal Investigator: Allexis $729,875 Bcr and PPARγ as targets for transplant arteriopathy. The proposal focuses on transplant arteriopathy the leading cause of long-term morbidity and mortality following heart transplantation. The principal investigator’s long term goal is to understand how transcription factors regulate SMC gene expression that contributes to transplant arteriopathy. Role: Mentor (Abe). Haodong Xu (2005-), Associate Professor. Mentor and teach molecular and cellular biology. 1K08HL088127 08/15/2007-04/30/2012 Principal Investigator: Xu $621,080 Role of Modulation of Ito,f by Kinases in Cardiac Dysrhythmias This project will determine the molecular mechanisms by which p90RSK regulates Ito.f channel activity, and thereby prolongs cardiac repolarization, and predisposes to dysrhythmias. Role: Mentor (Abe). Chang-Hoon Woo (2009-), Research Assistant Professor. Mentor and teach molecular and cellular biology and heart physiology. Hakjoo Lee (2008-), Research Assistant Professor. Mentor and teach molecular and cellular biology and analysis of atherosclerosis. 6. Continuing Professional Medical Education: N/A 6
  7. 7. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 B. PROFESSIONAL SERVICE ASSIGNMENTS AND RESPONSIBILITIES OF THE LAST FIVE YEARS: 2003 Chair, Genetic Insights into cardiomyocyte biology, ACC scientific session, Chicago, IL 2004- Member of Institutional Biosafety Committee 2004- American Heart Association Scientific Sessions, Abstract Grading Consultant 2005- Pathology and pathways of human disease (PTH510) 2007- Co-Director, Cardiovascular Biology and Disease (CVS 401) 2007 Moderator, Novel Mechanism of ischemic injury and repair (AOP.37.3), AHA scientific session, Orlando FL 2008 AHA Upstate NY Cardiovascular Research Symposium, 2008 Dec 5, Abstract Grading Consultant 2009 Reviewer of scientific merit of “Role ERK5 activation in regulating PPARα activity and subsequent cardioprotection after ischemia/reperfusion” 2009 Member of Melvin L. Marcus Young Investigator Award Review Committee C. PROFESSIONAL ADMINISTRATIVE ASSIGNMENTS AND RESPONSIBILITIES OF LAST FIVE YEARS: 2006- Co-Director, Cardiovascular Biology and Disease (CVS-401) 2008- Director, Virus Core of Aab Cardiovascular Research Institute 7
  8. 8. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 D. RESEARCH ACTIVITIES: 1. Research Grants Obtained: 1.1a Ongoing NIH RO1 HL088637 12/01/2007-11/30/2011 20% Principal Investigator: Abe $1,468,165 Kinase-mediated SUMOylation in diabetic cardiomyopathy The long-term goal of this project is to understand the molecular mechanisms of how hyperglycemia contributes to diabetes-related heart disease with focus on the modulation of PDE3A-ICER feedback loop by ERK5-SUMOylation. Role: PI NIH P01 HL077789 (Program Project Grant) 8/2005-7/2010 20% Project 2, Project Leader: Abe $1,531,406 Vascular Inflammation and Atherosclerosis There is increasing support for the idea that inflammation plays a major role in the development of atherosclerosis. This study investigates the role of BMK1 on flow-mediated PPARγ1 transcriptional activity as well as it’s subsequent anti-inflammatory effects. Role: Project Leader, Project 2, PPARγ, Endothelial Inflammation, and atherosclerosis. AHA Established Investigator Award 0740013N 1/2007-12/2011 15% Principal Investigator: Abe $500,000 p90RSK-mediated ERK5-SUMOylation and endothelial inflammation in diabetes The goal of this study is to investigate whether the inhibition of ERK5 transcriptional activity in diabetes by p90RSK-mediated ERK5-SUMOylation enhances endothelial inflammation and atherosclerosis formation. Role: PI NIH R01 HL088400 12/1/07-11/30/11 10% Principal Investigator: Yan $1,250,000 Regulation and Function of Phosphodiesterase in the Heart The objective of this project is to understand the regulation and function of PDE3A isoform in cardiac gene expression and the progression of heart failure. Role: Co-Investigator NIH 5 R01 HL 64839-05 8/5/2005-7/31/2009 3% Principal Investigator: Berk $1,250,000 Fluid Shear Stress Signal Transduction in Endothelium This project investigates the mechanisms by which steady laminar flow inhibits activation of JNK by TNF. The focus is on BMK1 and SHP2-mediated activation by flow and their roles to inhibit ASK- mediated JNK activation Role: Co-investigator. NIH R01 HL 089885 4/2008-3/31/13 3% Principal Investigator: Blaxall $1,250,000 Defining the functional role of Mena in the heart The goal of this grant is to determine the functional role of the mammalian homologue of drosophila enabled (Mena) in the heart, particularly regarding its regulation downstream of b-AR signaling which is commonly aberrant in heart failure. 8
  9. 9. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 Role: Co-investigator. NIH 5 R01 HL 049192 12/1/08-11/30/13 5% Principal Investigator: Berk $1,250,000 Oxidative Stress and Vascular Smooth Muscle These studies will analyze the role of oxidative stress in mediating the growth responses of vascular smooth muscle cells. Role: Co-investigator 1.1b As a mentor i) KO8 and equivalent awards 5 K01 HL080938 8/1/05-7/31/10 Principal Investigator: Allexis (Assistant Professor) $729,875 Bcr and PPARγ as targets for transplant arteriopathy. The proposal focuses on transplant arteriopathy the leading cause of long-term morbidity and mortality following heart transplantation. The principal investigator’s long term goal is to understand how transcription factors regulate SMC gene expression that contributes to transplant arteriopathy. Role: Mentor. 1K08HL088127 08/15/2007-04/30/2012 Principal Investigator: Xu (Assistant Professor) $621,080 Role of Modulation of Ito,f by Kinases in Cardiac Dysrhythmias This project will determine the molecular mechanisms by which p90RSK regulates Ito.f channel activity, and thereby prolongs cardiac repolarization, and predisposes to dysrhythmias. Role: Mentor. 1.2a Completed NIH R01 HL65262 9/99-8/03 20% Principal Investigator: Abe $642,056 Bcr Kinase in PDGF-Mediated Effects in Vascular Smooth Muscle Bcr kinase is rapidly activated by PDGF in VSMC and Bcr overexpression enhances ERK1/2 activity in CHO cells expressing PDGF receptor. Therefore, our main hypothesis in this project is that Bcr, activated by PDGF, may increase the VSMC migration and proliferation and thereby contribute to atherosclerosis and restenosis. Role: PI NIH R01 HL66919 9/00-8/04 20% Principal Investigator: Abe $1, 000,000 Role of p90RSK in Diabetic Cardiomyopathy There is increasing support for the idea that excessive production of reactive oxygen species (ROS) contributes to the pathogenesis of diabetes. We have developed a novel hypothesis based on data from our laboratory that p90 ribosomal S6 kinase (p90RSK) is a physiological substrate of PKCβ2, and that Troponin I (TnI) phosphorylation by p90RSK contributes to decreased cardiac function in diabetes. Role: PI AHA GRANT-IN-AID 0455783T 7/04-6/07 15% Principal Investigator: Abe $181,500 Role of nuclear translocation of Grb2-associated binder 1 in atherosclerosis formation 9
  10. 10. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 The major goal of this project is to test our hypothesis that disturbed flow induced Gab1 nuclear translocation via ROS regulates sustained ERK1/2 and Egr-1 nuclear translocation, and increases subsequent pro-thrombotic and atherogenic factor such as tissue factor (TF) and PDGF-B expression in endothelial cells Role: PI TAKEDA PHARMACEUTICALS, INC 7/04-6/07 35% Principal Investigator: Abe $181,500 PPARγ, Molecular Mechanism of Atherosclerosis The goal of this study is to determine the effect of PPARg agonist on endothelial ERK5, JNK, NF-kB activation and VCAM-1 expression in diabetes and atherosclerosis model in vivo by using “en face confocal microscopy”. Role: PI NIH RO1 GM071485 4/05-3/09 17% Principal Investigator: Yang/Abe, sub-award $440,050 Big MAP kinase 1-Cx43 signaling in ischemia injury This study investigates the role of preconditioning-mediated BMK1 activation, which may phosphorylate Cx43, decrease gap junction coupling, and reduce ischemia/reperfusion-induced cellular Ca2+ overload. Role: Co-investigator (Sub-award from Columbia University) NIH 5 R01 HL 64839-05 8/5/2005-7/31/2009 3% Principal Investigator: Berk $1,250,000 Fluid Shear Stress Signal Transduction in Endothelium This project investigates the mechanisms by which steady laminar flow inhibits activation of JNK by TNF. The focus is on BMK1 and SHP2-mediated activation by flow and their roles to inhibit ASK- mediated JNK activation Role: Co-investigator. 1.2b Postdocoral fellowship awards AHA postdoctoral fellowship award 0325769T 7/1/2003-6/30/2005 Principal Investigator: Itoh $76,000 Role of p90RSK and renin-angiotensin system in ischemic myocardium The project will investigate whether renin-angiotensin system activation induced by p90RSK-mediated up-regulation of pro-renin converting enzyme contributes to Ca2+ overload and mitochondrial dysfunction. Role: Mentor. AHA postdoctoral fellowship award 0625957T 7/1/2006-6/30/2008 Principal Investigator: Woo $76,000 The role of ERK5-SUMOylation on hyperglycemia-mediated endothelial inflammation The project will investigate whether ERK5-SUMOylation induced by high glucose is a “key” modulator of ERK5 activity and enhances endothelial inflammation by reducing shear stress-mediated ERK5- SUMOylation. Role: Mentor. 1.3 Pending NIH 2R01 HL 064839-09 (Score, 6.0%) 1/2010-1/2015 20 % Principal Investigator: Abe (MPI) $1,780,431 10
  11. 11. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 Fluid Shear Stress Signal Transduction in Endothelium The major hypothesis of this proposal is that PKCζ activation in EC at atheroprone areas inhibits ERK5- dependent transcriptional activity and stimulates p53-SUMOylation thereby promoting EC inflammation and apoptosis. Role: Principle investigator (MPI). NIH 1R01HL102746 4/01/2010-3/31/15 20 % Principal Investigator: Abe (MPI) $1,476,635 p90RSK; A flow responsive mediator of inflammation The major hypothesis is that p90RSK activation in EC by hyperglycemia and disturbed flow has significant role in EC apoptosis and inflammation via SENP2 and ERK5 phosphorylation. Role: Principle investigator (MPI). RC1 HL100051 (Score, 8.0%) 09/30/09-09/29/11 5% Principal Investigator: R.P. Phipps $650,408 Microparticles as Messengers of Communication Between Blood and Vascular Cells This project will determine how platelet derived microparticles influence nucleated cells such as the white blood cells and endothelial cells. Role: Co-investigator. 2. Research Supervisory Assignments: Scott J. Cameron (2000), Graduate Student. Member, Thesis Committee. Advised and corroborated on his project concerning the assay of BMK1 and determination of the phosphorylation sties of BMK1 on Connexin 43. Qunhua Huang (1999- 2002), Postdoctoral Research Associate. Supervised and taught cell biology and molecular biology Wenyi Che (2000 -2004), Postdoctoral Research Associate, (2004-2005) Instructor. Supervised and taught cell biology and generation of transgenic mice. Changxi Zhang (2000 - 2001), Postdoctoral Research Associate Supervised and taught cardiovascular physiology (Langendorff), biochemistry and molecular biology. Seigo Ito (2001 - 2005), Postdoctoral Research Associate Supervised and taught cardiovascular physiology (Langendorff), biochemistry and molecular biology. AHA postdoctoral fellowship awardee AHA postdoctoral fellowship award 0325769T 7/1/2003-6/30/2005 Principal Investigator: Itoh $76,000 Role of p90RSK and renin-angiotensin system in ischemic myocardium The project will investigate whether renin-angiotensin system activation induced by p90RSK-mediated up-regulation of pro-renin converting enzyme contributes to Ca2+ overload and mitochondrial dysfunction. Role: Mentor. Shinsuke Ohta (2000-2001), Postdoctoral Research Associate. Taught biochemistry and genotyping of transgenic mice. Christopher P. Baines (1999-2000), Postdoctoral Research Associate. Taught generation and handling of transgenic mice. 11
  12. 12. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 Masashi Akaike (2002-2003), Visiting Scientist. Supervised and taught cell biology and molecular biology. Qinlei Zheng (2002 - 2005). Member, Thesis Committee. Advised on her project about the role of 14-3-3 on BMK1 activation. Xinchun Pi (2003 - 2005). Advised on her project about the role of BMK1 activation on HIF-1 transcriptional activity. Masaki Osawa (2002-2003), Postdoctoral Research Associate. Supervised and taught cell biology and molecular biology. Jennifer Hom (2004-2009 ). Member, Thesis Committee. Advised on her project about the role of Ca2+ on mitochondria function. Bo Ding (2002 - 2006), Postdoctoral Research Associate, (2006-2007) Instructor. Supervised and taught cell biology and molecular biology. Jeffery Allexis (2004-), Assistant Professor. Mentor and teach molecular and cellular biology. KO1 awardee (equivalent for KO8) 5 K01 HL080938 8/1/05-7/31/10 Principal Investigator: Allexis (Assistant Professor) $729,875 Bcr and PPARγ as targets for transplant arteriopathy. The proposal focuses on transplant arteriopathy the leading cause of long-term morbidity and mortality following heart transplantation. The principal investigator’s long term goal is to understand how transcription factors regulate SMC gene expression that contributes to transplant arteriopathy. Role: Mentor. Haodong Xu (2005-), Assistant Professor. Mentor and teach molecular and cellular biology. KO8 awardee 1K08HL088127 08/15/2007-04/30/2012 Principal Investigator: Xu (Assistant Professor) $621,080 Role of Modulation of Ito,f by Kinases in Cardiac Dysrhythmias This project will determine the molecular mechanisms by which p90RSK regulates Ito.f channel activity, and thereby prolongs cardiac repolarization, and predisposes to dysrhythmias. Role: Mentor. Zhibo Lu (2005-2008). Postdoctoral Research Associate. Supervise and teach cell biology and molecular biology. Tetsuro Shishido (2006-2008) Postdoctoral Research Associate. Supervise and teach cell biology and molecular biology. Chang-Hoon Woo (2006-) Postdoctoral Research Associate. Supervise and teach cell biology and molecular biology. AHA postdoctoral fellowship awardee AHA postdoctoral fellowship award 0625957T 7/1/2006-6/30/2008 12
  13. 13. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 Principal Investigator: Woo $76,000 The role of ERK5-SUMOylation on hyperglycemia-mediated endothelial inflammation The project will investigate whether ERK5-SUMOylation induced by high glucose is a “key” modulator of ERK5 activity and enhances endothelial inflammation by reducing shear stress-mediated ERK5- SUMOylation. Role: Mentor. AHA Scientist Development Grant 0930360N 01/01/2009 - 12/31/2012 Principal Investigator: Woo $308,000 ERK5-SUMOylation, CHIP and ICER stability in diabetes: Involvement in apoptosis after myocardial infarction This project investigates the mechanism by which ERK5-SUMOylation induces myocyte apoptosis via ICER protein stabilization. The focus is on ERK5-mediated CHIP ubiquitin ligase activation and ICER ubiquitination. Gwenaele Garin (2005-2007) Postdoctoral Research Associate. Supervised and taught cell biology and molecular biology. Shaozhen Xie (2006-2007) Postdoctoral Research Associate, Advised on his project about the role of TR4 on atherosclerosis formation, and supervised and taught vascular biology. Shi Xi (2006-) Graduate Student. Advise on her project about the role of p90RSK on cardiac remodeling after myocardial infarction, and supervise and teach cell biology and molecular biology. Eugene Chang (2007-) Graduate Student, Advisor. Mentor on his project regarding the role of p90RSK on ERK5-SUMOylation and mitochondrial function. Fatbardha Varfai (2007). Chair, Thesis Committee. Emily A. Oestreich (2007). Chair, Thesis Committee. Alon Mantel (2007-). Member, Thesis Committee. Kimio Saito (2006-2008), Postdoctoral Research Associate. Supervise and teach cell biology and molecular biology. Cameron World (2006-), Postdoctoral Research Associate. Supervise and teach cell biology and molecular biology. Lingli Li (2006-2008), Postdoctoral Research Associate. Supervise and teach cell biology and molecular biology. Patrizia Nigro (2008-), Postdoctoral Research Associate, Supervise and teach cell biology and molecular biology. New New Soe (2009-), Postdoctoral Research Associate, Supervise and teach cell biology and molecular biology. Chiung-Kuei Huang (2009-), Member, Thesis Committee, 13
  14. 14. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 E. PRESENTATIONS AT MAJOR NATIONAL PROFESSIONAL MEETINGS (2008-): Basic Cardiovascular Science Conference, Jul 28-31, 2008, Keystone, CO. • The cardioprotective role of ERK5 in diabetes-mediate exacerbation of cardiac dysfunction after myocardial infarction through ubiquitin ligase CHIP-mediate ICER degradation. Chang-Hoon Woo, Tetsuro Shishido, Jun-ichi Abe, Basic Cardiovascular Science Conference, 2008, P39; 30 American Heart Association Scientific Session, Nov 8-12, 2008, New Orleans, LA • Cyclophilin A promotes vascular oxidative stress and accelerates development of angioteinsin II-induced aortic aneurysms. Kimio Satoh, Patrizia Nigro, Tetsuya Matoba, Michael R O’Dell, Zhaoqiang Cui, Xi Shi, Amy Mohan, Chen Yan, Jun-ichi Abe, Bradford C Berk. Circulation 2008; S323:1428 • Protein kinase C-zeta (PKCz) is a novel mediator of endothelial dysfunction by inhibiting the ERK5/Kruppel-like Factor 2 (KLF2) pathway. Patrizia Nigro, Chang-Hoon Woo, Antonietta Belisario, Carolyn McClain, Jun-ichi Abe, Bradford C. Berk. Circulation 2008; S464: 3678 • Regulation of shear stress-induced anti-inflammatory responses. Jun-ichi Abe • SUMO-dependent Regulation of ERK Family Kinases in Atherosclerosis. Jun-ichi Abe Upstate NY Cardiovascular Research Symposium, Dec 5, 2008, Rochester, NY. • PKCζ activation induced by disturbed flow (d-flow) and peroxinitrate (ONOO-) plays a key role in endothelial cell (EC) apoptosis via PIASy-mediated p53-SUMOylation. Kyung-Sun Heo, Jun-ichi Abe, Patrizia Nigro, Tamlyn Thomas, Bradford C. Berk, Keigi Fujiwara, Chang-Hoon Woo. AHA Upstate NY Cardiovascular Research Symposium, 2008 Dec 5. Keystone Symposia, 2009 Jan 11-16, The many faces of Ubiquitin, Copper Mountain, Colorado. • Novel role of E3 ubiquitin ligase, C-terminus of Hsp70-interacting protein (CHIP), on myocyte apoptosis via regulating ERK5-mediated inducible cAMP early repressor (ICER) degradation. Chang-Hoon Woo, Tetsuro Shishido, Carolyn McClain, Thomas Spangenberg, Chen Yan, Burns C. Blaxall, Cam Patterson, and Jun-ichi Abe. Keystone Symposia, 2009 Jan 11-16, The many faces of Ubiquitin. Keystone Symposia, 2009 Feb 24-Mar 1, Dissecting the vasculature: Function, Molecular Mechanisms, and malfunction. British Columbia, Canada. • PKCζ activation induced by disturbed flow (d-flow) and peroxinitrate (ONOO-) plays a key role in endothelial cell (EC) apoptosis via PIASy-mediated p53-SUMOylation. Kyung-Sun Heo, Jun-ichi Abe, Patrizia Nigro, Tamlyn Thomas, Bradford C. Berk, Keigi Fujiwara, Chang-Hoon Woo. F. EDITORIAL ASSIGNMENTS IN PROFESSIONAL JOURNALS: 1. Journal of Molecular and Cellular Cardiology (Editorial Board 2001 - ) (2003, 2004 Place on the Journal’s Top Ten list of Reviewers) 14
  15. 15. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 2. Arteriosclerosis, Thrombosis and Vascular Biology (Editorial Board 2007 - ) 3. Circulation Research (Editorial Board 2009 -) 4. The Open Hematology Journal (Editorial Board 2008 - ) 5. The Open Nitric Oxide Journal (Editorial Board 2008 - ) 6. Journal of Cell Death (Editorial Board 2008 - ) 7. International Journal of Clinical and Experimental Medicine (Editorial Board 2009 - ) Reviewer for: Circulation Circulation Research Journal of the American College of Cardiology American Journal of Physiology American Journal of Pathology American Journal of Cardiology Oncogene Journal of Biological Chemistry Journal of Pathology Journal of Applied Physiology Experimental Brain Research Experimental Cell Biology Antioxidant and Redox Signaling Physiological Genomics Life Science Hypertension Journal of Clinical Investigation Journal of Proteome Research Metabolism Molecule Page for the UCSD-Nature Signaling Gateway Diabetes Journal of the American Society of Hypertension PLoS One G. MEMBERSHIP AND PARTICIPATION IN NATIONAL ADVISORY AND HEALTH COUNCILS AND RESEARCH REVIEW COMMITTEES OF LAST FIVE YEARS: American Heart Association, Basic Cardiovascular Science Council Fellow of the American Heart Association and the Council on Basic Cardiovascular Sciences North American Vascular Biology Organization (NAVBO) FASEB, American Society for Biochemistry & Molecular Biology International Society for Heart Research (ISHR) Research Review Committees 2002 Ad hoc reviewer, Research Peer Review Committee, NIH, Council ZDK1 GRB-9 01 R, Innovative Partnerships in type 1 diabetes research 15
  16. 16. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 2002.2004 American Heart Association, Cardiovascular Pathophysiology Two (National) Peer Review Committee 2004-present American Heart Association Scientific Sessions, Abstract Grading Consultant 2004 Ad hoc reviewer, U.S. Department of Agriculture, Small Business Innovation Research. 2005 American Heart Association (Northeast affiliate), NEA5B (Cellular/Molecular Genetics & Signaling) Peer Review Committee 2005 American Heart Association (Northeast affiliate), NEA6 (CV Dev) Peer Review Committee 2005 Ad hoc reviewer, Research Peer Review Committee, NIH, Council ZDK1 GRB-4 01, Collaborative Studies on Angiogenesis and Diabetic Complications. 2006American Heart Association, NEA4 (Molecular Signaling; Immunology & Microbiology), Peer Review Committee 2006 American Heart Association, NEA6 (Cell Structure & Function) (Northeast affiliate) Peer Review Committee 2006 Ad hoc reviewer, Research Peer Review Committee, NIH, PPG ZHL1 SRC (99), Role of innate immunity in atherosclerosis 2007 American Heart Association, NEA4 (Molecular Signaling; Immunology & Microbiology) (Northeast affiliate) Peer Review Committee 2007-present American Heart Association, VASC2 (Vascular Wall Biology 2) (National) Peer Review Committee 2007 Ad hoc reviewer, Research Peer Review Committee, NIH, ZRG1 DIG-B 52, Exploratory Research Centers of Excellence for Minority Health Disparities (P20) 2007 Ad hoc reviewer, Research Peer Review Committee, NIH, ZAR1 MLB-G O1 1, Center for Research Translation 2007 Ad hoc reviewer, Research Peer Review Committee, NIH, Atherosclerosis and inflammation of the cardiovascular system study section (AICS). 2008- Scientific advisory board, Abstract Grading Consultant, 14th World Congress on Heart Disease, Toronto, ON, Canada, July 26 - 29, 2008. 2008 Ad hoc reviewer, Research Peer Review Committee, CDC, 2008-R02 Improving postpartum follow up in women with gestational diabetes-affected pregnancy. 2008 Ad hoc reviewer, Research Peer Review Committee, U.S. Civilian Research & Development Foundation and Russian Federation Ministry of Education and Science, 2008 BRHE Project Grants Competition. 2009 Ad hoc reviewer, Research Peer Review Committee, NIH, PPG 1 PO1 HL096545-01, “Role of O-Glc-NAc in inflammatory Mediated Cardiovascular injury”. 2009- Charter member, Research Peer Review Committee, NIH, Atherosclerosis and inflammation of the cardiovascular system study section (AICS). 2009 Ad hoc reviewer, Research Peer Review Committee, NIH, ZHL1 PPG 2 PO1 HL075443-06, “Novel Mechanisms and Therapies in Heart Failure”. 2009 Ad hoc reviewer, National Natural Science Foundation of China (NSFC)/Research Grants Council (RGC) of Hong Kong Joint Research Scheme H. CONSULTATIONS TO UNIVERSITIES, HEALTH AND SCIENCE AGENCIES: Collaboration with Dr. Chen Yan, University of Rochester, on the role of BMK1 kinase on PDE3 activity, as well as subsequent cardiomyocytes apoptosis. Collaboration with Dr. Jay Yang, University of Wisconsin-Madison, on the role of BMK1 activation in regulating Cx43 gap junction communication. 16
  17. 17. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 Collaboration with Dr. Serge Lemay, McGill University, on the role of Dok4 in regulating mitochondrial function. Collaboration with Dr. Paul Brookes, University of Rochester, on the role of Src kinase family in regulating mitochondrial function. Collaboration with Dr. Bradford C. Berk, University of Rochester, on the role of BMK1 activation on HIF-1 transcriptional activity. Collaboration with Dr. Michael Massett, University of Rochester, about the role of BMK1 activation on mitochondrial biogenesis in skeletal muscle. Collaboration with Dr. Yasuchika Takeishi, Yamagata University, about the role of DG kinase in cardiomyocytes Collaboration with Dr. Jack Taunton, UCSF, about the role of p90RSK activation in diabetes. Collaboration with Dr. Burns C. Blaxall, University of Rochester, about the role of PAR-1 in cardiac remodeling. Collaboration with Dr. Richard Phillips, University of Rochester, to detect microparticles influence on nucleated cells such as the white blood cells and endothelial cells. 17
  18. 18. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 I. PUBLICATIONS: Original Scientific Articles 1. Abe J, Yamaguchi T, Isshiki T, Naka H, Kawada Y, Katayama Y. Rapid quantiation of serum myoglobin by latex agglutination turbidimetry. Clinica Chimica Acta 203:95-96, 1991. 2. K Ohara, Abe J, Murakami T. Neuronal hyaline inclusions observed in autopsy case of Behget's disease. Acta Pathologica Japonica 42:432-438, 1992. 3. Abe J, Yamaguchi T, Isshiki T, Naka H, Taguchi J, Ishizaka N, Kurokawa K, Saeki F, Ishizaka Y, Ui K, Ikara Y, Somitsu Y, Hashimato H, Kashida M. Myocardial reperfusion can be predicted by myoglobin/creatine kinase ratio of a single blood sample obtained at the time of admission. Amer Heart J 126:279-285, 1993. 4. Taguchi J, Abe J, Okazaki H, Ochiai M, Ohno M, Takuwa Y, Kurokawa K. L-arginine inhibits neointimal formation following balloon injury. Life Sci 53:PL387, 1993. 5. Taguchi J, Abe J, Okazaki H, Ochiai M, Ohno M, Takuwa Y, Kurikawa K. Angiotensin converting enzyme inhibitors or Dup753 prevent neointimal formation balloon injury with single topical or multiple systemic application. Biochem Biophys Res Commun 196:969-974, 1993 6. Abe J, Zhou W, Taguchi J, Takuwa N, Miki K, Okazaki H, Kurokawa K, Kumada M, Takuwa Y. Suppression of neointimal smooth muscle cell accumulation in vivo by antisense cdc2 and cdk2 oligonucleotides in rat carotid artery. Biochem Biophys Res Commun 198:16-24, 1994 7. Ishizaka N, Isshiki T, Saeki F, Ishizaka Y, Ikari Y, Abe J, Somitsu Y, Hashimoto H, Masaki K, Yamaguchi T. Angiographic follow-up after successful percutaneous coronary angioplasty for chronic total coronary occlusion: Experience in 110 consecutive patients. Am Heart J 127:8-12, 1994. 8. Abe J, Zhou W, Takuwa N, Taguchi J, Kurokawa K, Kumada M, Takuwa Y. A fumagillin- derivative angiogenesis inhibitor, AGM-1470, inhibits activation of cyclin-dependent kinases and phosphorylation of retinoblastoma gene product but not protein tyrosyl phosphorylation or protooncogene expression in vascular endothelial cells. Cancer Res 54:3407-3412, 1994. 9. Taguchi J, Abe J, Ohno M, Schwartz SM, Kurokawa K. Topical application of AT1 receptor antagonists prevents medial and neointimal proliferation after balloon injury. Blood Press Suppl 1994;5:38-42. 10. Schiojima I, Ikari Y, Abe J, Ishizaka N, Maemura K, Kurihara H, Isshiki T, Suma H, Saeki H, Hara K, Tamura T, Yamaguchi T. Thrombotic occlusion of the coronary artery associated with accidental detachment of undeployed Palmaz-Schatz stent. Cathet Cardiovasc Diagn 1996;38:360-362. 11. Abe J, Kusuhara M, Ulevitch RJ, Berk BC, Lee J-D: Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase. J Biol Chem 271: 16586-16590, 1996. 12. Abe J, Takahashi M, Ishida M, Lee J-D, Berk BC. c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase-1 (BMK1). J Biol Chem 1997;272:20389-20394. 13. Takahashi E, Abe J, Berk BC. Angiotensin II stimulates p90rsk in vascular smooth muscle cells. A potential Na+/H+ exchanger kinase. Circ Res 1997;81:268-273. 14. Abe J, Deguchi J, Matsumoto T, Takuwa N, Noda M, Ohno M, Makuuchi M, Kurokawa K, Takuwa Y. Stimulated activation of platelet-derived growth factor receptor in vivo in balloon-injured arteries. A link between angiotensin II and intimal thickening. Circulation 1997;96: 1906-1913 18
  19. 19. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 15. Abe J, Deguchi J, Takuwa Y. Tyrosine phosphorylation of platelet-derived growth factor - receptors in coronary artery lesions: Implications of vascular remodeling after directional coronary atherectomy and unstable angina pectoris. Heart 1998;79: 400-406 16. Abe J, Berk BC. Reactive oxygen species as mediators of signal transduction in cardiovascular disease. Trends in Cardiovasc Med 1998;8: 59-64 17. Kusuhara M, Takahashi E, Peterson TE, Abe J, Ishida M, Han J, Ulevitch R, Berk BC. p38 Kinase is a Negative Regulator of Angiotensin II Signal Transduction in Vascular Smooth Muscle Cells: Effects on Na+/H+ Exchange and ERK1/2. Circ Res 1998 Oct 19;83(8):824-31 18. Abe J, Berk BC. Fyn and JAK2 mediate Ras Activation by Reactive Oxygen Species. J Biol Chem, 1999, 274: 21003-21010. 19. Takahashi E, Abe J, Gallis B, Aebusold R, Spring DJ, Krebs E, Berk BC. p90RSK is a serum- stimulate NHE1 kinase: regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1. J Biol Chem, 1999, 274:20206-20214. 20. Deguchi J, Namba T, Hamada H, Nakaoka T, Abe J, Sato O, Miyata T, Makuuchi M, Kurokawa K, Takuwa Y. Targetting endogenous platelet-derived growth factor B-chain by adenovirus-mediated gene transfer potently inhibits in vivo smooth muscle proliferation after arterial injury. Gene Therapy 1999; 6 (6): 956-965. 21. Takeishi Y Abe J*, Lee JD, Walsh, RA Berk BC. Differential Regulation of p90RSK and BMK1 by Ischemia/Reperfusion and Oxidative Stress in Perfused Guinea Pig Hearts. Circ Res, 1999, 85: 1164-1172. *Corresponding author 22. Deguchi J, Abe J, Makuuchi M, Takuwa Y. Inhibitory effects of trapidil on PDGF signalling in balloon-injured rat carotid artery. Life Sci 1999; 65 (26): 2791-9. 23. Abe J, Okuda M, Huang Q, Yoshizumi M, Berk BC. Reactive Oxygen Species Activate p90 Ribosomal S6 Kinase via Fyn and Ras. J Biol Chem. 2000 Jan 21;275(3):1739-1748. 24. Abe J, Yoshizumi M, Haendeler J, Huang Q, Berk BC. Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by Reactive Oxygen Species. J Biol Chem. 2000, 275:11706-11712. 25. Yan C, Luo H, Lee JD, Abe J, and Berk BC. Molecular Cloning of Mouse ERK5/BMK1 Splice Variants and Characterization of ERK5 Functional Domains. J Biol Chem. 2001, 276:10870-10878 26. Lehoux S, Abe J, Florian JA, and Berk BC. 14-3-3 binding to NHE-1 is associated with serum dependent activation of Na+/H+ exchange. J Biol Chem. 2001, 276: 15794-15800 27. Che W, Abe J#, Yoshizumi m, huang Q, Glassman M, Ohta S, Melaragno MG, Poppa V, Yan C, lerner-Marmarosh N, Zhang C, Wu Y, Arlinghaus R, Berk BC. P160 Bcr mediates Platelet-Derived growth factor Activation of Extracellular Signal-Regulated kinase in Vascular Smooth Muscle Cells. Circulation 2001, 104:1399-1406. #Corresponding author 28. Abe J*, Takeishi Y*, Huang Q*, Che W, Lee J-D, Kawakatsu H, Hoit B.D., Berk B.C., Walsh R.D. Src and multiple MAP kinase activation in cardiac hypertrophy and in congestive heart failure under chronic pressure-overload: Comparison with acute pressure-overload model in guinea pig heart. Journal of Mol Cell Cardio, 2001 33:1637-1648. 29. Takeishi Y*, Huang Q*, Yoshizumi M, Lee JD, Kawakatsu H, Baines CP, Che W, Walsh RA, Berk BC, Abe J*#. Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium : Modulation by Ischemic Preconditioning. J Mol Cell Cardiol. 2001 33(11):1989-2005. 19
  20. 20. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 30. Abe J*, Takeishi Y*, Huang Q*, Che W, Lee J-D, Kawakatsu H, Hoit B.D., Berk B.C., Walsh R.D. Activation of Multiple Mitogen-Activated Protein Kinases and p90 Ribosomal S6 Kinase in Failing Human Hearts with dilated cardiomyopathy. Cardiovasc Res. 2002 53(1):131-7. 31. Berk, BC, Abe, J., Min, W., Surapisitchat, J., Yan, C. Endothelial atheroprotective and anti- inflammatory mechanism. Ann. NY. Acad. Sci. 2001, 93-111 32. Saito S., Hojo Y, Tanimoto T, Abe J, Berk BC. Protein Kinase C-α and Protein kinase C-ε are required for Grb2-associated Binder-1 Tyrosine Phosphorylation in response to Platelet-derived Growth Factor. J. Biol. Chem, 2002 Jun 28;277(26):23216-22 33. Che W*, Lerner-Marmarosh N*, Huang Q, Osawa M, Ohta S, Yoshizumi M, Glassman M, Lee JD, Yan C, Berk BC, and Abe J*#. Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: Role of Gab1 and MEKK3 in TNF-α induced c-Jun and NF-κB activation and adhesion molecule expression. Circ Res, 2002 Jun 14;90(11):1222-30 34. Huang Q*, Lerner-Marmarosh N*, Che W, Ohta S, Osawa M, Yoshizumi M, Glassman M, Yan C, Berk BC, and Abe J*#. The novel role of C-terminal region of SHP-2 : Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation. J. Biol. Chem. 2002 277: 29330-29341 35. Tai LK, Okuda M, Abe J, Yan C, Berk BC. Fluid shear stress activates Pyk2 via a reactive oxygen species dependent pathway. Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1790-1796. 36. Yoshizumi M, Abe J, Tsuchiya K, Berk BC, Tamaki T. Stress and vascular responses: atheroprotective effect of laminar fluid shear stress in endothelial cells: possible role of mitogen- activated protein kinases. J Pharmacol Sci. 2003 Mar;91(3):172-6. 37. Abe J*, Cameron SJ*, Malik S, Akaike M, Lerner-marmarosh N, Yan C, Lee JD, Yang J. Regulation of Epidermal Growth Factor-induced Connexin 43 Gap Junction Communication by Big Mitogen-Activated Kinase 1/ERK5 but not ERK1/2 Kinase Activation. J. Biol. Chem. 2003. 278:18682-8 38. Lerner-Marmarosh N, Yoshizumi M, Che W, Surapisitchat J, Kawakatsu H, Akaike M, Ding B, Huang Q, Yan C, Berk BC, Abe J. Inhibition of Tumor Necrosis Factor-α-Induced SHP-2 Phosphatase Activity by Shear Stress. A Mechanism to Reduce Endothelial Inflammation. Arterioscler Thromb Vasc Biol, 2003 Oct;23(10):1775-1781. 39. Aizawa T, Wei H, Miano JM, Abe J, Berk BC, Yan C. Role of phosphodiesterase 3 in NO/cGMP- mediated antiinflammatory effects in vascular smooth muscle cells. Circ Res. 2003 93(5):406-13. 40. Abe J*, Cameron SJ*, Malik S, Che W, Yang J. Differential role of MEK5α and Mek5β in BMK1/ ERK5 activation. J Biol Chem. 2004 279:1506-1512 41. Osawa M, Itoh S, Ohta S, Huang Q, Berk BC, Lerner-Marmarosh N, Che W, Ding B, Yan C, and Abe J. ERK1/2 associates with the c-Met binding domain of Gab1: Role in ERK1/2 and Egr-1 nuclear accumulation. J Biol Chem. 2004 79(28):29691-9 42. Cameron SJ, Itoh S, Baines CP, Zhang C, Ohta S, Che W, Glassman M, Lee JD, Yan C, Yang J, and Abe J. Activation of Big MAP Kinase 1 (BMK1/ERK5) inhibits cardiac injury after myocardial ischemia and reperfusion. FEBS letter. 2004 May 21;566(1-3):255-60 43. Akaike M, Che W, Lerner-Marmarosh N, Ohta S, Osawa M, Ding B, Berk BC, Yan C, and Abe J. 20
  21. 21. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 The Hinge-helix1 region of PPARγ1 mediates interaction with ERK5 and PPARγ1 transcriptional activation: Involvement in flow-induced PPARγ activation in endothelial cells. Mol Cell Biol. 2004 Oct;24(19):8691-8704 44. Abe J*, Ding B*, Wei H, Huang Q, Walsh RA, Molina CA, Zhao A, Sadoshima J, Blaxall BC, Berk BC, Yan C. Functional role of phosphodiesterase 3A (PDE3A) in cardiomyocyte apoptosis: Implication in heart failure. Circulation. 2005 May 17;111(19):2469-76. 45. Itoh S, Ding B, Bains C.P., Wang N, Takeishi Y, Jalili T, King GL, Walsh RA, Yan C, and Abe J. Role of p90 Ribosomal S6 Kinase (p90RSK) in reactive oxygen species and PKCβ-mediated cardiac Troponin I phosphorylation. J Biol Chem. 2005 Jun 24;280(25):24135-42. 46. Itoh S, Lemay S, Osawa M, Che W, Duan Y, Tompkins A, Brookes PS, Sheu SS, and Abe J. Mitochondrial Dok-4 recruits Src kinase and regulates NF-kB activation in endothelial cells. J Biol Chem. 2005 Jul 15;280(28):26383-96. 47. Abe J*, Ding B, Wei H, Xu H, Che W, Aizawa T, Liu W, Molina CA, Sadoshima J, Blaxall BC, Berk BC, Yan C. A positive feedback loop pf phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis. Proc Natl Acad Sci USA, 2005 Oct 11;102 (41):14771-6. (Editorial 102: 14483-14484) 48. Pi X, Garin G, Xie L, Zheng Q, Wei H, Abe J, Yan C, Berk BC. BMK1/ERK5 is a novel regulator of angiogenesis by destabilizing hypoxia inducible factor 1alpha. Circ Res. 2005 Jun 10;96(11):1145-51. 49. Takahashi H, Takeishi Y, Seidler T, Arimoto T, Akiyama H, Hozumi Y, Koyama Y, Shishido T, Tsunoda Y, Niizeki T, Nozaki N, Abe J, Hasenfuss G, Goto K, Kubota I. Adenovirus-mediated overexpression of diacylglycerol kinase-zeta inhibits endothelin-1-induced cardiomyocyte hypertrophy. Circulation. 2005 Mar 29;111(12):1510-6. 50. Itoh S, Ding B, Shishido T, Lerner-Marmarosh N, Wang N, Maekawa N, Berk BC, Takeishi Y, Yan C, Blaxall BC, and Abe J. Role of p90 Ribosomal S6 Kinase (p90RSK)-mediated Pro-renin Converting Enzyme (PRECE) in Ischemic and Diabetic Myocardium. Circulation, 2006 Apr 11;113(14):1787-1798. 51. Abe J*, Maekawa N*, Shishido T, Ding B, Itoh S, Sharma VK, Sheu SS, Blaxall BC, Berk BC. Inhibiting p90 ribosomal S6 kinase prevents cardiac ischemia-reperfusion injury. Circulation, 2006; 113:2516-2523. 52. Arimoto T, Takeishi Y, Takahashi H, Shishido T, Niizeki T, Koyama Y, Shiga R, Nozaki N, Nakajima O, Nishimaru K, Abe J, Endoh M, Walsh RA, Goto K, Kubota I. Cardiac-specific overexpression of diacylglycerol kinase zeta prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice. Circulation. 2006 Jan 3;113(1):60-6. 53. Shishido T, Nozaki N, Takahashi H, Arimoto T, Niizeki T, Koyama Y, Abe J, Takeishi Y, Kubota I. Central role of endogenous Toll-like receptor-2 activation in regulating inflammation, reactive oxygen species production, and subsequent neointimal formation after vascular injury. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1446-53. 21
  22. 22. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 54. Laplante P, Raymond MA, Labelle A, Abe J, Iozzo RV, Hebert MJ. Perlecan proteolysis induces an alpha 2beta 1 integrin and Src-family kinases dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation. J Biol Chem. 2006 Oct 13;281(41):30383-92. 55. Woo CH, Massett MP, Shishido T, Itoh S, Ding B, McClain C, Che W, Vulapalli SR, Yan C, Abe J. ERK5 activation inhibits inflammatory responses via peroxisome proliferators-activated receptor delta (PPARdelta ) stimulation. J Biol Chem. 2006 Oct 27;281(43):32164-74 56. Goubaeva F, Mikami M, Giardina S, Ding B, Abe J, Yang J. Cardiac mitochondrial connexin 43 regulates apoptosis. Biochem Biophys Res Commun. 2007 Jan 5;352(1):97-103. 57. Yan C, Ding B, Shishido T, Woo C-H, Itoh S, Jeon K-I, Liu W, Xu H, McClain C, Molina CA, Blaxall BC, Abe J. Activation of ERK5 reduces cardiac apoptosis and dysfunction via inhibition of a PDE3A-ICER feedback loop. Circ Res. 2007 Mar 2;100(4):510-9. 58. Yan C, Miller CL, Abe J. Regulation of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) in the heart (Review). Circ Res. 2007 Mar 2;100(4):489-501. 59. Garin G, Abe J, Mohan A, Lu W, Yan C, Newby AC, Rhaman A, Berk BC. Flow Antagonizes TNF-{alpha} Signaling in Endothelial Cells by Inhibiting Caspase-Dependent PKC{zeta} Processing. Circ Res. 2007 Jul 6;101(1):97-105. 60. Pawlinski R, Tencati M, Hampton CR, Shishido T, Bullard TA, Casey LM, Andrade-Gordon P, Kotzsch M, Spring D, Luther T, Abe J, Pohlman TH, Verrier ED, Blaxall BC, Mackman N. Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy. Circulation. 2007 Nov 13;116(20):2298-306. 61. Woo C-H, Shishido T, McClain C, Lim JH, Li JD, Yang J, Yan C, Abe J. ERK5-SUMOylation antagonizes shear stress-induced anti-inflammatory response and eNOS expression in endothelial cells. Circ Res. 2008 Mar 14;102(5):538-45 62. Li L, Tatake RJ, Natarajan K, Taba Y, Garin G, Tai C, Leung E, Surapisitchat J, Yoshizumi M, Yan C, Abe J, Berk BC. Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells. Biochem Biophys Res Commun. 2008 May 23;370(1):159-63. 63. Satoh K, Matoba T, Suzuki J, O'Dell MR, Nigro P, Cui Z, Mohan A, Pan S, Li L, Jin ZG, Yan C, Abe J, Berk BC. Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation. Circulation 2008 Jun 6;102(11):1416-25. 64. Shishido T, Woo C-H, Ding B, McClain C, Molina CA, Yan C, Yang J, Abe J. Association of MEK5 with ERK5, but not ERK5 kinase activation, inhibits small ubiquitin-related modification of ERK5 kinase (ERK5-SUMOylation), and prevents diabetes-mediated exacerbation of left ventricular dysfunction after myocardial infarction. Circ Res. 2008 Jun 6;102(11):1416-25. 65. Abe J*, Lu Z*, Taunton J, Lu Y, Shishido T, McClain C, Yan C, Xu SP, Spangenberg TM, Xu H. Reactive Oxygen Species-Induced Activation of p90 Ribosomal S6 Kinase Prolongs Cardiac Repolarization Through Inhibiting Outward K+ Channel Activity. Circ Res. 2008 Aug 1;103(3):269-78. 66. Alexis JD, Wang N, Che W, Lerner-Marmarosh N, Sahni A, Korshunov VA, Zou Y, Ding B, Yan C, Berk BC, and Abe J. Bcr kinase activation by Angiotensin II inhibits PPARγ transcriptional activity 22
  23. 23. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 in vascular smooth muscle cells. Circ Res. 2009 Jan 2;104(1):69-78. 67. Satoh K, Nigro P, Matoba T, O'Dell MR, Cui Z, Shi X, Mohan A, Yan C, Abe J, Illig KA, and Berk BC. Cyclophilin A promotes vascular oxidative stress and accelerates development of angiotensin II- induced aortic aneurysms. Nature Med. 2009 Jun;15(6):649-56. 68. Xiea S, Leea Y-F, Kima E, Chena L-M, Nia J, Fanga L-Y, Liua S, Lina S-J, Abe J, Berk BC, Feng- Ming Hoa FM, and Changa C. TR4 nuclear receptor functions as a fatty acid sensorto modulate CD36 expression and foam cell formation. PNAS, 2009 in press *Equally contributed 1st author Editorials 1. Abe J, Baines CP, Berk BC. Role of Mitogen-Activated Protein Kinases in Ischemia and Reperfusion Injury : The Good and the Bad. Circ Res 2000 86: 607 - 609. 2. Abe, J, and Berk BC. Hypoxia and HIF-1α stability: another stress sensing mechanism for Shc. Circ. Res. 2002 91: 4-6 3. Abe J. Bone morphogenetic protein (BMP) family, SMAD signaling and Id helix-loop-helix proteins in the vasculature: The continuous mystery of BMPs pleotropic effects. J Mol Cell Cardiol. 2006 Jul;41(1):4-7. 4. Abe J. Role of PKCs and NF-kappaB activation in myocardial inflammation: Enemy or ally? J Mol Cell Cardiol. 2007 Oct;43(4):404-8. 5. Abe J, Woo CH. NADPH oxidase in vascular injury: a new insight about its regulation and role in T cells. Circ Res. 2009 Jan 30;104(2):147-9. Book Chapters 1. Abe, J., Yan C., Surapisitchat J, Berk BC. Kinase Signaling in the Cardiovascular System, 2000, Academic Press, N. Sperelakis (editor). Heart Physiology and Pathophysiology, 4th edition, 657-677. 2. Abe, J., Berk BC. Reactive Oxygen Species as Mediators of Signal Transduction in Cardiovascular Disease, 2000 Kluwer Academic Publishers, J.-C. Tardif and M.G. Bourassa (editors), Antioxidant and Cardiovascular Disease 57-70. 3. Berk BC, Surapistchat J, Yoshizumi M, Yan C, Hoefen R, Abe J. Atheroprotective mechanisms of fluid shear stress: Nitic oxidide independent inhibition of signal transduction mediated by inflammatory cytokines. 2001, IOS Press, Cataravas JD, Callow AD, Ryan US, Simionescu M. Vascular endothelium Source and target of inflammatory Mediators, NATO Science Series, p115- p125 Abstracts 1. The Role of big MAP Kinase 1 (BMK1) as a Redox Sensitive Kinase in Vascular Smooth Muscle Cells Abe J, kusuhara M, Ulevitch RJ, Lee JD, Berk BC. Circulation 1996;94(8):I-280. 2. p90RSK : A putative Na+/H+ exchanger kinase that is activated by ERK1/2 in vascular smooth muscle cells. Takahashi E, Abe J, Kusuhara M, Berk BC. Circulation 1997;96(8):I-159. 3. Platelet-Derived Growth Factor (PDGF) Stimulates Bcr Kinase in Vascular Smooth Muscle Cells (VSMC) : Mediation by 14-3-3ß Interaction with Phosphatidylinositol 3’-Kinase and Phospholipase Cg Abe J, Kusuhara M, Berk BC. Circulation 1998;96(8):I-298. 23
  24. 24. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 4. c-Src but not Fyn is Required for Oxidative Stress-Mediated activation of Big Mitogen-activated protein Kinase-1 (BMK1). Abe J, Takahashi M, Ishida M, Lee JD, Kusuhara M, Berk BC. Circulation 1998;96(8):I-159. 5. Identification of serine 703 in Na+/H+ exchanger isoform-1 as the site of p90rsk phosphorylation by angiotensin II Takahashi E, Abe J, Berk BC. Circulation 1998;98(17):I-822. 6. p160 Bcr Mediates Platelet-Derived growth Factor (PDGF) Activation of Extracellular Signal- Regulated Kinase (ERK1/2) Abe J, Berk BC. Circulation 1998;98(17):I-327. 7. Reactive Oxygen Species Regulates Janus Kinase 2 (JAK2) via a Pathway Dependent on Fyn Abe J, Ishida M, Ishida T, Takahashi E, Okuda M, ueba H, Luo Honglin, Kusuhara M, Yan C. Circulation 1998;98(17):I-220. 8. Fyn-Dependent Activation of p90 Ribosomal S6 Kinase (RSK) by H2O2: A New Redox Sensitive Pathway Abe J, Berk BC. Circulation 1998;98(17):I-220. 9. p160 Bcr Mediates Platelet-Derived growth factor (PDGF) Activation of Extracellular Signal- Regulated Kinase (ERK1/2) : Role of Syp (SH-PTP2) Tyrosine Phosphatase. Abe J, Yoshizumi M, Yan C. Circulation 1999;100(18):I-616. 10. Fyn is required for oxidative stress-mediated activation of Rap1 GTPase Abe J, Yoshizumin M, Yan C, Berk BC. Circulation 1999;100(18):I-409. 11. Ischemic preconditioning alters p90RSK and BMK1 activation after ischemia/reperfusion. Takeishi Y, Abe J, Lee JD, Walsh RA, Berk BC. Circulation 1999;100(18):I-325. 12. 14-3-3 is a serum stimulated Na+/H+ exchanger binding protein Lehoux S, Abe J, Berk BC. Circulation 1999;100(18):I-280. 13. p90 Ribosomal S6 Kinase Phosphorylation Serine 703 of Human Na+/H+ Exchanger Isoform-1 and Regulates its Function in Vivo. Takahashi E, Abe J, Gallis BM, Aebersold R, Spring DJ, Berk BC. Circulation 1999;100(18):I-280. 14. Hydrogen Peroxide Stimulates Tyrosine Phosphorylation of Proline Rich-Tyrosine Kinase 2 and Focal Adhesion Kinase in Bovine Aortic Endothelial Cells. Okuda M, Abe J, Schaefer E, Berk BC. Circulation 1999;100(18);I-264. 15. c-Src is required for hydrogen peroxide activation of c-Jun N-terminal kinase (JNK), but not extracellular signal-regulated kinase (ERK1/2) and p38 kinase Yoshizumi M, Abe J, Haendeler J, Berk BC. Circulation 1999;100(18):I-263. 16. Differential Regulation of p90RSK and BMK1 by Ischemia/Reperfusion and Oxidative Stress in Perfused Guinea Pig Hearts. Takeishi Y, Abe J, Lee JD, Walsh RA, Berk BC. Circulation 1999;100(18):I-260. 17. Activation of Multiple Mitogen-Activated Protein Kinases and p90 Ribosomal S6 Kinase in Failing Human Hearts. Takeishi Y, Huang Q, Abe J, Abraham WT, Wagoner LE, Hoit BD, Walsh RA. Circulation 2000;102(18):II-449. 18. Bcr regulates PDGF-Induced SHP-2 Phosphatase Activity and Interaction with Gab1. Huang Q, Che W, Yoshizumi M, Abe J. Circulation 2000;102(18):II-354. 19. Caveoline-1 Protein Expression is Downregulated in Vascular Smooth Muscles Cells in Responses to PDGF. Peterson TE, Abe J, Kleppe LS, Muesuke CS, Mookadam M, Simari RD. Circulation 2000;102(18):II-181. 20. Shear Stress Inhibits Tumor Necrosis Factor-a (TNF-a) Induced JNK Activation via Protein-tyrosine Phosphatase SHP-2 Yoshizumi M, Surapisitchat J, Abe J, Yan C, Berk BC. Circulation 2000;102(18):II-37. 24
  25. 25. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 21. Involvement of Gab1 and SHP-2 on H2O2-induced Multiple MAP Kinases Activation. Che W, Huang Q, Yan C, Abe J. Circulation 2000;102(18):II-123. 22. Src Family Kinase and Adenosine Differentially Regulate Multiple MAP Kinases in Ischemic Myocardium: Modulation by Ischemic Preconditioning. Huang Q, Yasuchika T, Che W, Baines CP, Yoshizumi M, Walsh RA, Abe J. Circulation 2000;102(18):II-211. 23. Differential Activation of Mitogen-Activated Protein (MAP) Kinase Family and p90 Ribosomal S6 Kinase (RSK) in Hypertrophied Myocardium Induced by Pressure-Overload Takeishi Y, Huang Q, Abe J, Che W, Lawrence EG, Hoit BD, Walsh RA. Circulation 2000;102(18):II-70. 24. Activation of p90 Ribosomal S6 Kinase in Murine Hearts Overexpressing Protein Kinase C ßII but not Protein Kinase Ce. Baines CP, Huang Q, Takeishi Y, King CL, Walsh RA, Abe, J. Circulation 2000;102(18):II-70. 25. Laminar shear stress inhibits TNF-a-induced JNK activation via SHP-2 tyrosine phosphatase in HUVEC. Yoshizumi M, Surapistichat J, Abe J, Berk BC, and Tamiki T. Hypertension Research 2001 Vol.24, No.1 066. 26. Shear stress inhibits TNF-a induced JNK activation via protein-tyrosine phosphatase SHP-2; possible role of MEK5/BMK1 Abe J. Proceedings of the Second Aso International Meeting (AIM), Kumamoto, Japan, May 2001. 27. Bcr mediates Platelet-Derived Growth factor (PDGF) Activation of Extracellular signal-Regulated Kinase (ERK1/2) in Vascular Smooth Muscle Cells: involvement of Ras and raf-1 Activation by bcr. Abe J, Arlinghaus R, Berk BC. Proceedings of the Sixth Saratoga International Conference on Atherosclerosis, Tokyo, Japan, April 2001. 28. Shear Stress Stimulation of PYK2 Phosphorylation through ROS. Tai LK, Abe J, Berk BC. Circulation 2001;104(17):II-70. 29. Role of SHP-2 tyrosine phosphatase in regulating TNF-α induced ICAM-1 expression: Implication of MEKK3 and subsequent c-Jun and NF-κB activation in endothelial cells. Marmarosh N, Che W, Ohta S, Huang Q, Zhang C, Glassman M, Yan C, Abe J. Circulation 2001;104(17):II-147. 30. Bcr regulates PDGF-induced Elk-1 activation via modulating SHP-2/Gab-1 complex formation. Huang Q, Ohta S, Marmarosh N, Abe J. Circulation 2001;104(17):II-223. 31. Effect of Grb-2 associate binding protein 1 (Gab1) on reactive oxygen species (ROS) and TNF- a signaled pathway and subsequent adhesion molecules expression in endothelial cells. Che W, Marmarosh N, Ohta S, Huang Q, Zhang C, Glassman M, Yan C, Abe J. Circulation 2001;104(17):II-201. 32. Atheroprotective effect of laminar fluid shear stress in endothelial cells : possible role of MAP kinases. Yoshizumi M, Abe J, Tsuchiya K, Berk BC, Tamaki T. The Japanese Journal of Pharmacology. Vol 88 Supplement I 2002 S35-2 33. Mechanical Stress Activates Src and Big Mitogen-activated Protein Kinase-1 (BMK1) in the heart. Takeishi Y. Abe J, Kubota I, Walsh RA. International Society for Heart Research, The 19th annual Meeting of the Japanese Section, Yamagata, Japan. Oct 31, 2002. 34. BMK1/ERK5 Disrupts Connexin Gap Junctional Communication and Inhibits Intracellular [Ca2+] Overload after Myocardial Ischemia. Cameron SJ, Malik S, Itoh S, Bains CP, Zhang C, Osawa M, Ohta S, Lerner-Marmarosh N, Huang Q, Che W, Glassman M, Lee JD, Sheu SS, Zhu JQ, Yasuchika T, Yan C, Berk BC, Yang J, Abe J. Circulation 2002: 106 (19): II-6. 25
  26. 26. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 35. Role of Novel Adaptor Protein DOK-4 in Regulating of Mitochondrial Function in Endothelial Cell (EC). Itoh S, Osawa M, Lemay S, Bedrian A, Abe J. Circulation 2003: 108 (17): IV-3. 36. Hinge-Helix1 Region of PPARγ1 (Hin-H1-PPARγ1) Mediates Interaction with ERK5 and PPARγ1 Transcriptional Activation: Involvement in Shear Stress-Induced PPARγ Activation in Endothelial Cells (ECs). Abe J, Akaike M, Che W, Ohta S, Osawa M, Yan C.. Circulation 2003: 109 (17) IV-108. 37. Flow-induced Peroxisome Proliferator-Activated Receptors-γ Activation via ERK5 Kinase Activation and Association Inhibits Vascular Cell Adhesion Molecular-1 Expression in Endothelial Cells. Akaike M, Che W, Lerner-Marmarosh N, Ohta S, Osawa M, Ding B, Berk BC, Yan C, Abe J. Circ Res 2004: 94 (12): online supplementary information 38. Activation of ERK5 inhibits persistent downregulation of phosphodiesterase 3A1 (PDE3A1) and prevents pressure overload-induced cardiac apoptosis and dysfunction. Ding B, Yan C, Blaxall BC, Abe J. Circulation 2004: 110 (17) III-64. 39. Inhibiting ribosomal S6 kinase (RSK) prevents Na+/H+ exchanger isoform 1 (NHE-1)-mediated cardiac ischemia-reperfusion (I/R) injury. Maekawa N, Abe J, Ding B, Berk BC. Circulation 2004: 110 (17) III-67. 40. Mitochondrial DOK-4 recruits Src kinase and regulates mitochondria (Mito)-derived reactive oxygen species (ROS) and subsequent NF-κB activation in endothelial cells. Itoh S, Osawa M, Che W, Bedrian A, Tompkins AJ, Brookes PS, Lemay S, Abe J. Circulation 2004: 110 (17) III-90. 41. Diaglycerol Kinase ζ-inhibits endothelin-1-induced cardiomyocyte hypertrophy. Takahashi H, Takeishi Y, Seidler T, Arimoto T, Akiyama H, Shishido T, Koyama Y, Abe J, Goto K, Kubota I. Circulation 2004: 110 (17) III-156. 42. Big Mitogen-activated protein (MAP) kinase 1 (BMK1) is a novel regulator of hypoxia-inducible factor 1a. Pi X, Xie L, Zheng Q, Abe J, Wei H, Ohta S, Yan C, Berk BC. Circulation 2004: 110 (17) III-306. 43. Effect of Bcr serine/threonine kinase on angiotensin II-mediated NF-κB transcriptional activation in vascular smooth muscle cells (VSMC): Involvement of PPARγ activity inhibition via Bcr. Alexis JD, Che W, Ding B, Ito S, Wang NB, Korshunov VA, Berk BC, Yan C, and Abe J. Circulation 2005: 112 (17) II-204. 44. Effect of insulin growth factor-1 (IGF-1)-induced ERK5 activation ERK5 activation on a novel positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER)- mediated apoptosis: Akt independent cell survival pathway. Ding B, Yan C, Molina CA, Blaxall BC, and Abe J. Circulation 2005: 110 (17) II-219. 45. Functional role of p90 ribosomal S6 kinase (p90RSK)-mediated P{ro-renin converting enzyme (PRECE) induction: Implication in Diabetic (DM) myocardium. Abe J, Itoh S, Lerner-Marmarosh N, Ding B, Wang N, Maekawa N, Takeishi Y, Blaxall BC, Yan C. Circulation 2005: 110 (17) II-274. 46. ERK1/2 associated with c-Met-binding domain of growth factor receptor-bound protein (Grb2)- associated binder-1 (Gab1): Role in ERK1/2 and early growth response factor-1 (Egr-1) nuclear accumulation. Osawa M, Itoh S, Ohta S, Huang Q, Berk BC, Lerner-Marmarosh N, Che W, Ding B, 26
  27. 27. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 Yan C, and Abe J. Keystone Symposia 2005, The Cellular Biology of Atherosclerosis, p.42 47. Hinge-helix 1 region of PPARγ mediates interaction with ERK5 and PPARγ transcriptional acrtivation: Involvement in flow-induced PPARg activation in endothelial cells. Akaike M, Che W, Lerner-Marmarosh N, Ohta S, Osawa M, Ding B, Berk BC, Yan C, Abe J. Keystone Symposia 2005, PPAR/LXR, p.89 48. Bcr inhibits PPARγ activation and enhances NF-κB transciptional activation in vascular smooth muscle cells. Alexis JD, Che W, Ding B, Ito S, Wang N, McClain C, Korshunov VA, Berk BC, Yan C, Abe J. Keystone Symposia 2006, Molecular Biology of the Vasculature, p.94 49. Atypical PKC Zeta mediates TNF Induced Endothelial Dysfunction. Garin G, Abe, J, Yan C, Liu W, Newby A, Rahman A, Berk BC. Circulation 2006: 114 (18) II-84. 50. ERK5 Activation Regulates PPARalpha Activity and Subsequent Cardioprotection After Ischemia/Reperfusion. Ding B, Yan C, Liu W, Shishido T, Woo CH, McClain C, Abe J. Circulation 2006: 114 (18) II-98. 51. Heme Oxygenase-1 and Carbon Monooxide Releasing Compound, {Ru(CO)3Cl2]2, -induced ERK5 Activation Inhibits Inflammatory Responses via Peroxisome Proliferator-activated Receptor Stimulation in Skeletal Muscle. Woo CH, Massett M, Shishido T, Ding B, Yan C, McClain C, Abe J. Circulation 2006: 114 (18) II-160. 52. Angiotensin II and Reactive Oxygen Species (ROS) Induce ERK5-SUMOyaltion and Inhibits ERK5 Transcriptional Activity: Implication in Diabetic Cardiomyopathy. Shishido T, Woo CH, Ding B, McClain C, Lu Z, Xu H, Yan C, Abe J. Circulation 2006: 114 (18) II-84. 53. PB1 Domain Mediates PKCz and p62 Interaction Regulates Flow-Induced ERK5 Activation. Garin G, Abe J, Yan C, Liu W, Newby A, Rahman A, Berk BC. Circulation 2006: 114 (18) II-297. 54. ERK5-SUMOylation antagonizes shear stress-induced anti-inflammatory response and eNOS expression in endothelial cells. Chang-Hoon Woo, Tetsuro Shishido, Carolyn McClain, Jae Hyang Lim, Jian-Dong Li, Jay Yang, Chen Yan, and Jun-ichi Abe. Cell Signaling, fourth annual symposium, Dundee, UK, Aug 30-Sep 2, 2007. 55. Reactive oxygen species (ROS) and advanced glycation end products (AGE)-induced ERK5- SUMOylation antagonizes anti-inflammatory effect of shear stress in endothelial cells. Chang-Hoon Woo, Tetsuro Shishido, Carolyn McClain, Chen Yan, and Jun-ichi Abe. FASEB 2007: 21 (5) A294. 56. Reactive oxygen species-induced p90 Ribosomal S6 Kinase Activation leads to prolongation of cardiac repolarization via inhibiting voltage-gated outward K+ currents. Zhibo Lu, Jun-ichi Abe, Jack Taunton, Tetsuro Shishido, Carolyn McClain. Haodong Xu. Circulation 2007; 116: II 118 57. Blockade of diabetes (DM)-mediated p90RSK activation reduces small ubiquitin-related modification of ERK5 kinase (ERK5-SUMOylation) and DM-induced exacerbation of left ventricular (LV) remodeling after myocardial infarction (MI). Tetsuro Shishido, Chang-Hoon Woo, Bo Ding, Carolyn McClain, Chen Yan, Haodong Xu, Jun-ichi Abe. Circulation 2007; 116: II 101 58. Association of ERK5 with MEK5 (upstream kinase of ERK5), but not ERK5 kinase activation, 27
  28. 28. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 inhibits small ubiquitin-related modification of ERK5 kinase (ERK5-SUMOylation), and prevents diabetes (DM)-mediated exacerbation of left ventricular (LV) remodeling after myocardial infarction (MI). Tetsuro Shishido, Chang-Hoon Woo, Bo Ding, Carolyn McClain, Zhibo Lu, Haodong Xu, Chen Yan, Jun-ichi Abe. Circulation 2007; 116: II 211 59. Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation. Kimio Satoh, Tetsuya Matoba, Michael O’Dell, Lingli Li, Jun Suzuki, Shi Pan, Sarah Mack, Amy Mohan, Zheng-Gen Jin, Joseph M Miano, Jun-ichi Abe, Bradford C. Berk. Circulation 2007; 116: II 150 60. The cardioprotective role of ERK5 in diabetes-mediate exacerbation of cardiac dysfunction after myocardial infarction through ubiquitin ligase CHIP-mediate ICER degradation. Chang-Hoon Woo, Tetsuro Shishido, Jun-ichi Abe, Basic Cardiovascular Science Conference, 2008, P39; 30 61. Cyclophilin A promotes vascular oxidative stress and accelerates development of angioteinsin II- induced aortic aneurysms. Kimio Satoh, Patrizia Nigro, Tetsuya Matoba, Michael R O’Dell, Zhaoqiang Cui, Xi Shi, Amy Mohan, Chen Yan, Jun-ichi Abe, Bradford C Berk. Circulation 2008; S323:1428 62. Protein kinase C-zeta (PKCz) is a novel mediator of endothelial dysfunction by inhibiting the ERK5/ Kruppel-like Factor 2 (KLF2) pathway. Patrizia Nigro, Chang-Hoon Woo, Antonietta Belisario, Carolyn McClain, Jun-ichi Abe, Bradford C. Berk. Circulation 2008; S464: 3678 63. PKCζ activation induced by disturbed flow (d-flow) and peroxinitrate (ONOO-) plays a key role in endothelial cell (EC) apoptosis via PIASy-mediated p53-SUMOylation. Kyung-Sun Heo, Jun-ichi Abe, Patrizia Nigro, Tamlyn Thomas, Bradford C. Berk, Keigi Fujiwara, Chang-Hoon Woo. AHA Upstate NY Cardiovascular Research Symposium, 2008 Dec 5. 64. Novel role of E3 ubiquitin ligase, C-terminus of Hsp70-interacting protein (CHIP), on myocyte apoptosis via regulating ERK5-mediated inducible cAMP early repressor (ICER) degradation. Chang-Hoon Woo, Tetsuro Shishido, Carolyn McClain, Thomas Spangenberg, Chen Yan, Burns C. Blaxall, Cam Patterson, and Jun-ichi Abe. Keystone Symposia, 2009 Jan 11-16, The many faces of Ubiquitin. 65. PKCζ activation induced by disturbed flow (d-flow) and peroxinitrate (ONOO-) plays a key role in endothelial cell (EC) apoptosis via PIASy-mediated p53-SUMOylation. Kyung-Sun Heo, Jun-ichi Abe, Patrizia Nigro, Tamlyn Thomas, Bradford C. Berk, Keigi Fujiwara, Chang-Hoon Woo. Keystone Symposia, 2009, Feb 24-Mar 1, Dissecting the vasculature: Function, Molecular Mechanisms, and malfunction. 66. Disturbed flow-mediated Protein Kinase C-zeta activation plays a key role in endothelial cell apoptosis via PIASy (SUMO E3 ligase)-mediated p53-SUMOylation but not p53 transactivation. Heo KS, Abe J, Lee H, Nigro P, Le NT, Berk BC, Fujiwara K, Woo C-H. NAVBO, Vasculata, 2009, Jul 28-31. (Vasculata 2009 Scholarship and Abstract award recipient) 67. Role of MK2 in PIAS1-mediated Transrepression of NF-kB. Chang E, Woo C-H, Abe J. NAVBO, Vasculata, 2009, Jul 28-31. (Vasculata 2009 Abstract award recipient) 68. Cyclophilin A mediates endothelial damage and promotes recruitment of inflammatory cells and atherosclerosis. Nigro P, Satoh K, O'Dell MR, Soe N-N, Cui Z, Mohan A, Abe J, Alexis J, Goldman B, Sparks J-D, and Berk BC. (Vasculata 2009 Abstract award recipient) 28
  29. 29. Jun-ichi Abe, M.D., Ph.D., F.A.H.A. Curriculum Vitae November, 2007 69. The critical role of p90 Ribosomal S6 kinase (p90RSK) in endothelial eNOS expression is mediated by ERK5 transactivation via its SUMOylation and phosphorylation. Le N-T, Lee H, Heo K-S, Woo C-H, Nigro P, McClain C, Spangenberg T, Thomas T, Berk BC, Fujiwara K, Abe J. 29

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