CURRICULUM VITAE

                                   ZHONGLIN LIU, M.S, M.D.


CONTACT INFORMATION:

Department of Radiolo...
3. Explore the tumor-targeting properties of novel radioligands in animal models of human cancer
   and characterize the p...
Awarded Paper: Johnson G, Nguyen K N, Liu Z, Gao, Pasqualini P R, and Okada R D,
       Planar Imaging of 99mTc-labeled (b...
PROFESSIONAL ORGANIZATIONS:

Society of Nuclear Medicine
American Society of Nuclear Cardiology
American Heart Association...
Liu Z, Pei Z, Liu C, Piao Y, Zhu Y, and Hu S, Detecting myocarditis with 67Ga-citrate myocardial
imaging, Chin. J. Nucl. M...
Okada D R, Johnson III G, Liu Z, Hocherman S D, Khaw B A, Pak K Y, and Okada R D,
Myocardial kinetics of 99mTc-glucarate i...
Liu Z, Okada D R, Johnson G, Hocherman S D, Beju D, and Okada R D, 99mTc-sestamibi kinetics
predict myocardial viability i...
Z Liu and Z Pei, Diagnostic value of left ventricular volume and pressure-volume ratio (SBP/ESV)
changes during exercise t...
G Johnson III, P Gao, Z Liu, K N Nguyen, and R D Okada, Relationship of Tc-99m-sestamibi
kinetics and myocardial viability...
Z Liu, G Johnson III, D Beju, and R D Okada, Comparison of monocationic radiotracer kinetics in
hearts exposed to brief is...
G Johnson III, Z Liu, C J Higgins, D R Okada, R Pasqualini, R D Okada, Influence of blood
interactions and circulation tim...
Z Liu, G A Kastis, G D Stevenson, H H Barrett, L R Furenlid, D W Wilson, and J M Woolfenden,
Application of high-resolutio...
Z Liu, H H Barrett, G D Stevenson, L R Furenlid, D W Wilson, J M Woolfenden, and K Y Pak,
Sequential imaging in rat hearts...
Z Liu, L R Furenlid, Y Chen, G Stevenson, H H Barrett, and J M Woolfenden, Evaluating
cardioprotective effect of melatonin...
INVITED TALKS

Z Liu, Detection of myocardial viability in ischemic-reperfused rat hearts with 99mTc sestamibi,
Annual Int...
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  1. 1. CURRICULUM VITAE ZHONGLIN LIU, M.S, M.D. CONTACT INFORMATION: Department of Radiology University of Arizona P.O. Box 245067 Tucson, AZ 85724-5067 Phone: (520) 626-4248 Fax: (520) 626-2892 E-mail: zliu@radiology.arizona.edu CITIZENSHIP: United States of America PROFESSIONAL EXPERIENCE: 2005-present Research Associate Professor, Dept. of Radiology, University of Arizona, Tucson, AZ 2000.2005 Research Assistant Professor, Dept. of Radiology, University of Arizona, Tucson, AZ 1995.2000 Research Fellow, William K. Warren Medical Research Institute of the University of Oklahoma Health Sciences Center, Norman, Oklahoma 1991-1995 Assistant Professor, Dept. of Nuclear Medicine, China Medical University, Shenyang, Liaoning Province, China EDUCATION: 1988-1991 Master, Medical Imaging, Medical University, Shenyang, China 1984.1988 Residency, the 2nd University Hospital, China Medical University Shenyang, Liaoning Province, China 1979.1984 M.D., China Medical University, Shenyang, Liaoning Province, China RESEARCH EXPERIENCE: Radiology Research Laboratory, University of Arizona: 1. Implement and validate small-animal models of myocardial ischemia-reperfusion injury and develop molecular imaging techniques to detect and quantify the injury and its development 2. Determine the effects of cardioprotective strategies using molecular imaging techniques 1
  2. 2. 3. Explore the tumor-targeting properties of novel radioligands in animal models of human cancer and characterize the properties of these radioligands for evaluating tumor response to chemotherapy 4. Investigate the impacts of transplantation route on stem-cell outcome and track stem cells non- invasively 5. Develop bi-specific cytokine radioligands for inflammation imaging William K. Warren Medical Research Institute of the University of Oklahoma: 1. Optimized the most effective radiotracer for differentiating recurrently infarcted nonviable from stunned and low-flow viable myocardium 2. Investigated in vitro and in vivo properties of hypoxia avid imaging agents in identifying viable ischemic myocardium using rat and canine heart models 3. Characterized novel myocardial perfusion imaging agents in distinguishing myocardial ischemia, measuring myocardial blood flow, and determining myocardial viability 4. Explored radiotracer techniques for early detecting cardiotoxicity induced by chemotherapy drugs China Medical University: 1. Determined myocardial viability and ischemia-reperfusion injury using cardiac SPECT imaging 2. Developed functional imaging techniques for diagnosis of coronary heart disease 3. Established pre-rectal scintigraphic technique for measuring portal-system shunt in patients with cirrhosis 4. Conceived and developed novel anti-tumor radioimmunotoxin, 186Re-labeled trichosanthina, for anti-tumor therapy 5. Radiolabeled monoclonal antibodies with 186Re for tumor localization and radioimmunotherapy 6. Investigated the efficacy of tumor radioimmunotargeting with 99mTc-labeled monoclonal antibodies AWARDS AND HONORS: 2007 Winner of Sylvia Sorkin Greenfield Award for the Best Scientific Paper in Medical Physics, American Association of Physicists in Medicine Awarded Paper: Kim H, Furenlid L R, Crawford M C, Wilson D W, Barber H B, Peterson T E, Hunter W C J, Liu Z, Woolfenden J M, and Barrett H H, SemiSPECT: a small-animal SPECT imager based on eight CZT detector arrays. Med. Phys., 2006;33:465-474. 2003 The Journal of Nuclear Medicine’s 2nd Place Award for Basic Science Investigations, the Society of Nuclear Medicine Awarded Paper: Liu Z, Kastis G A, Stevenson G D, Barrett H H, Furenlid L R, Kupinski M A, Patton P D, and Wilson D W, Quantitative analysis of acute myocardial infarct in rat hearts with ischemia-reperfusion using a high-resolution stationary SPECT system, J. Nucl. Med., 2002;43:933-930. 1997 Best Scientific Paper Award in the Basic Science Category for Journal of Nuclear Cardiology, the American Society of Nuclear Cardiology 2
  3. 3. Awarded Paper: Johnson G, Nguyen K N, Liu Z, Gao, Pasqualini P R, and Okada R D, Planar Imaging of 99mTc-labeled (bis(N-ethoxy,N-ethyldithiocarbamato) nitride technetium (V) can detect resting ischemia, J. Nucl. Cardiol., 4:217-225, 1997. 1995 Young Teacher’s Prize of Fok Ying Tung Educational Foundation (Hong Kong), the State Education Commission of the People’s Republic of China 1994 Science and Technology Progress Award from Liaoning Province, China 1994 Honor of Outstanding Youth for Scientific Research, Teaching, and Medical Services, the Second Clinical College of China Medical University 1994 Second Place Prize in Excellent Research Paper Competition at the First Youth Academic Annual Meeting of Liaoining Province, the Satellite Meeting of the First Youth Academic Annual Conference of China Association for Science and Technology 1992 Third Place Prize of Excellent Scientific Papers Issued by Liaoning Province Association for Science and Technology, China 1991 Science and Technology Progress Award from the Health Ministry of the People’s Republic of China 1984 Honors Graduate, China Medical University RESEARCH GRANTS: Project Leader: “Techniques for Molecular Imaging, Center for Gamma-Ray Imaging,” NIBIB, H. H. Barrett, Principal Investigator, Awarded 2004 Principal Investigator: “In vivo assessment of chemotherapy response in human breast tumor xenografts using radiolabeled glucarate high-resolution imaging,” American Cancer Society IRG Grant (#IRG-110T), Arizona Cancer Center, Awarded 2003 Principal Investigator: “Oncosis, apoptosis, and cardioprotection in doxorubicin-induced cardiotoxicity: assessment with high-resolution SPECT imaging in a rat model,” Prop. 301: Imaging Small Grant Program, University of Arizona, Awarded 2002 Investigator: “Southwest Animal Imaging Resource,” National Cancer Institute, R. Gillies, Principal Investigator, Awarded 1999 Principal Investigator: “Experimental studies of 186Rhenium-labeled trichosanthin radio- immunotoxin against tumors,” National Natural Science Foundation of China (NNSFC), Awarded 1994 Principal Investigator: “99mTc-labeling monoclonal antibodies and tumor radioimmunoimaging,” Science and Technology Foundation of Liaoning Province, China, Awarded 1993 Principal Investigator: “Radiotracers studies of myocardial ischemia and reperfusion injury,” Young Investigator Foundation of China Medical University, Awarded 1991 3
  4. 4. PROFESSIONAL ORGANIZATIONS: Society of Nuclear Medicine American Society of Nuclear Cardiology American Heart Association - Basic Science Council EDITORIAL MEMBER AND REVIEWER: 1994-1997 Member and Reviewer of Editorial Board of the Journal of Clinical Medical Imaging, China 2004-2005 Reviewer for the Journal of Nuclear Medicine PROFESSIONAL REFERENCES: Available upon request PUBLICATIONS: Peer-Reviewed Articles: Quan Z, Liu Z, Pan Q, Gao Q, Xia Z, Gao S, and Cen Z, Diagnostic value of 99mTc-PMT positive imaging to primary hepatic carcinoma, Image Tech. Inform. Disp., 21:1242-1244, 1989. Quan Z, Liu Z, Pan Q, Li X, Wang H, and Li Z, Nuclear medicine diagnosis of GER in infantile esophageal hiatus hernia, Image Tech. Inform. Disp., 21(7):312-315, 1989. Liu Z, Pei Z, Zhang C, and Liu C, Radionuclide ventriculography nongeometric count-based method determining left ventricular volume, Acad. Exch., 8:1-5, 1991. Piao Y, Pei Z, and Liu Z, The diagnostic value of 67-Ga myocardial imaging to myocarditis, Chin. J. Pediat., 29:286-257, 1991. Liu Z, Pei Z, Liu C, Wang G, and Zhang C, Preliminary use of gated 99mTc-MIBI myocardial perfusion imaging for evaluating left ventricular function, Chin. J. Nucl. Medi., 12:151-153, 1992. Liu Z and Pei Z, Attenuation correction in absolute left ventricular volume measurement by radionuclide ventriculography, Chin. J. Nucl. Medi., 12:245, 1992. Liu Z, Pei Z, and Liu C, Pulmonary blood volume changes during exercise in patients with coronary heart disease determined by radionuclide scintigraphy, Chin. J. Nucl. Medi., 13:41-42, 1993. Liu Z, Pei Z, and Dai S, Bone scintigraphy in 21 patients with multiple myeloma, Chin. J. Nucl. Medi., 13:117, 1993. Liu Z, Wang Y, Liu Q, and Liu C, Quantitative measurement of portal-systemic shunt in patients with cirrhosis using radionuclides, Chin. J. Nucl. Medi., 13:223-225, 1993. 4
  5. 5. Liu Z, Pei Z, Liu C, Piao Y, Zhu Y, and Hu S, Detecting myocarditis with 67Ga-citrate myocardial imaging, Chin. J. Nucl. Medi., 13(4):244-245, 1993. Zang B, Shong G, Wu K, and Liu Z, Radionuclide cardiac blood pool imaging in patients with hypertrophy cardiomyopathy, Chin. J. Pract. Intern. Medi., 13(8):469-470, 1993. He P, Ma Z, Zhang C, and Liu Z, Study on ECT nuclide ventriculography determining the right ventricular function of patients with chronic pulmonary heart disease, Chin. J. Phys. Medi., 15(3):154-156, 1993. Liu Z, Jian L, Liu C, and Pei Z, Kinetics of norfloxacin floatable tablets in stomach determined with radiotracers, Chin. J. Nucl. Medi., 14:52, 1994. Liu Z, Pei Z, and Liu M, Abnormal 99mTc-MIBI myocardial perfusion imaging in patients with electrocution, Chin. J. Nucl. Medi., 14(2):105, 1994. Pao Y, Zhu Y, Lu H, Chen Y, Yu X, Pei Z, Liu Z, Zhang C, and Pei J, Diagnosing pediatric myocardial disease with 99mTc myocardial perfusion imaging, Chin. J. Medi., 74 (7):437-438, 1994. Liu Z, Pei Z, and Zhang B, Study of alterations in left ventricular volume and pressure to volume ratio during exercise in patients with coronary heart disease, Chin. J. Nucl. Medi., 14:83-86, 1994. Liao Y, Liu Z, and Pei Z, The value of radionuclide phase analysis in detecting old myocardial infarction, J. China Medi. Univ., 23(1):63-65, 1994. Pei J, Liu Z, Zhang Y, Pei Z, and Li X, 99mTc-EHIDA imaging analysis of congenital common bile duct cysts, J. China Medi. Univ., 23 (Supplement):126-127, 1994. Johnson G, Nguyen K N, Liu Z, Gao P, Pasqualini R, and Okada R D, Planar imaging of 99mTc- labeled (bis(N-ethoxy,N-ethyldithiocarbamato) nitride technetium (V) can detect resting ischemia, J. Nucl. Cardiol., 4:217-225, 1997. Okada R D, Johnson G, Nguyen K N, Liu Z, Edwards B, Archer C M, North T L, King A C, and Kelly J D, 99mTc-HL91 “hot spot” detection of ischemic myocardium in vivo by gamma camera imaging, Circulation, 97:2557-2566, 1998. Johnson G, Nguyen K N, Liu Z, and Okada R D, Technetium 99m-HL-91: a potential new marker of myocardium viability assessed by nuclear imaging early after reperfusion, J. Nucl. Cardiol., 5:285-294, 1998. Liu Z, Johnson III G, Beju D, and Okada R D, Detection of myocardial viability in ischemic- reperfused rat hearts by 99mTc-sestamibi kinetics, J. Nucl. Cardiol., 8:677-686, 2001. Liu Z, Kastis G A, Stevenson G D, Barrett H H, Furenlid L R, Kupinski M A, Patton D R, and Wilson D W, Quantitative analysis of acute myocardial infarction in rat hearts with ischemia- reperfusion using a high-resolution stationary SPECT system, J. Nucl. Medi., 43:933-939, 2002. 5
  6. 6. Okada D R, Johnson III G, Liu Z, Hocherman S D, Khaw B A, Pak K Y, and Okada R D, Myocardial kinetics of 99mTc-glucarate in low-flow, hypoxia, and aglycemia, J. Nucl. Cardiol., 10:168-176, 2003. Liu Z, Stevenson G D, Barrett H H, Kastis G A, Bettan M, Furenlid L R, Wilson D W, and Woolfenden J M, Imaging recognition of multidrug resistance in human breast tumors using 99mTc- labeled monocationic agents and a high-resolution stationary SPECT system, Nucl. Medi. Biol., 31:53-65, 2004. Liu Z, Stevenson G D, Barrett H H, Kastis G A, Bettan M, Furenlid L R, Wilson D W, Woolfenden J M, and Pak K Y, 99mTc-glucarate high-resolution imaging of drug-sensitive and drug- resistant human breast cancer xenografts in SCID mice, Nucl. Medi. Commun., 25:711-720, 2004. Liu Z, Stevenson G D, Kastis G A, Barrett H H, Bettan M, Furenlid L R, Wilson D W, and Pak K Y, High-resolution imaging with 99mTc-glucarate for assessing myocardial injury in rat models exposed to different durations of ischemia followed by reperfusion, J. Nucl. Medi., 45:1251-1259, 2004. Okada D R, Johnson G, Liu Z, Hocherman S D, Khaw B A, and Okada R D, Early detection of infarct in reperfused canine myocardium using 99mTc-glucarate, J. Nucl Medi., 45:655-664, 2004. Liu Z, Stevenson G D, Barrett H H, Kastis G A, Bettan M, Furenlid L R, Wilson D W, and Woolfenden J M, Imaging recognition of inhibition of multidrug resistance in human breast cancer xenografts using 99mTc-labeled sestamibi and tetrofosmin, Nucl. Medi. Biol., 32, 573-583, 2005. Kim H, Furenlid L R, Crawford M C, Wilson D W, Barber H B, Peterson T E, Hunter W C J, Liu Z, Woolfenden J M, and Barrett H H, SemiSPECT: a small-animal SPECT imager based on eight CZT detector arrays, Med. Phys., 33:465-474, 2006. Johnson G III, Okada C C, Hocherman S D, Liu Z, Hart C, Khaw B A, Okada R D, 99mTc-glucarate imaging for the early detection of infarct in partially reperfused canine myocardium, Eur. J. Nucl. Med. and Molec. Imag., 33:319-328, 2006. Liu Z, Zhao M, Zhu X, Furenlid L R, Chen Y-C, Barrett H H, In vivo dynamic imaging of myocardial cell death using 99mTc-labeled C2A domain of Synaptotagmin I in a rat model of ischemia and reperfusion, Nucl. Medi. Biol., 34:907-915, 2007. McLaughlin P J, Bakall B, Choi J, Liu Z, Sasaki T, Davis E C, Marmorstein A D, and Marmorstein L Y, Lack of Fibulin-3 causes early aging and herniation, but not macular degeneration in mice, Hum. Mol. Genet., 16:3059-3070, 2007. Liu Z, Barrett H H, Stevenson G D, Furenlid L R, Wilson D W, Woolfenden J M, and Pak K Y, Evaluating the protective role of ischemic preconditioning in rat hearts using a stationary small- animal SPECT imager and 99mTc-glucarate, Nucl. Medi. Commun., 29(2):120-128, 2008. 6
  7. 7. Liu Z, Okada D R, Johnson G, Hocherman S D, Beju D, and Okada R D, 99mTc-sestamibi kinetics predict myocardial viability in a perfused rat heart model, Eur. J. Nucl. Med. and Molec. Imag., 35;570-578, 2008. Chen L, Gobar L S, Knowles N G, Liu Z, Gmitro A F, Barrett H H, Direct imaging of radionuclide-produced electrons and positrons with an ultra-thin phosphor, J. Nucl. Med., Accepted, 2008. Okada D R, Johnson G, Liu Z, Hocherman S D, Beju D, and Okada R D, Monocationic radiotracer kinetics and myocardial infarct size: A perfused rat heart study, Ann. Nucl. Med., Accepted, 2008. Liu Z, Hui M M, Barrett H H, Furenlid L R, and Woolfenden J M, 99mTc-Labeled dual-domain cytokine ligand targeting interleukin-1 and interleukin-18 for SPECT imaging of inflammation, Nucl. Medi. Biol., Submitted, 2008. Liu Z, Stevenson G D, Barrett H H, Furenlid L R, Woolfenden J M, and Pak K Y, Targeting of human lung cancer xenografts with technetium-99m-glucarate, To be submitted, Nucl. Medi. Commun., 2008. Liu Z, Kim Y-S, Liu S, Furenlid L R, Barber C, Stevenson SD, Woolfenden J M, and Barrett H H, Rapid myocardial perfusion imaging in rat hearts with a novel cationic 99mTc(I)-tricarbonyl complex 99m Tc-15C5PNP characterized by low liver uptake, To be submitted, Nucl. Medi. Biol., 2008. ABSTRACTS AND PRESENTATIONS: Z Liu, Z Pei, and C Wang, Study of renogram and β2-MG in old patients with pulmonary heart disease in acute progress, The First Academic Conference of Northeast Federation of China, China Association for Medical Imaging Technology, Dandong, China, 1989. Z Liu, Radionuclide imaging demonstration of myocardial infarction by electrocution, The First Academic Conference of Nuclear Medicine of Northeast China, Mudanjiang, China, 1990. Z Liu and Z Pei, Preliminary application of 99mTc-MIBI gated myocardial imaging for left ventricular function determination, The First Academic Conference of Nuclear Medicine of Northeast of China, Mudanjiang, China, 1990. Z Liu and Z Pei, Comparative analysis of two kinds of ROI techniques for left ventricular systolic and diastolic function determination, The First Academic Conference of Nuclear Medicine of Northeast China, Mudanjiang, China, 1990. Z Liu, Z Pei, and C Liu, Study of left ventricular pressure-volume determination with RNA technology, The Third Annual Academic Meeting of the Society of Nucleonics of Liaoning Province, Shenyang, China, 1991. 7
  8. 8. Z Liu and Z Pei, Diagnostic value of left ventricular volume and pressure-volume ratio (SBP/ESV) changes during exercise to coronary artery disease determined with radionuclide ventriculography, Proceedings of the Second National Nuclear Cardiology Meeting, p. 46, Guangzou, China, 1992. Z Liu and Z Pei, Left ventricular volume and pressure-volume ratio alterations in patients with coronary heart disease induced by exercise test, The First Youth Academic Annual Meeting of Liaoining Province, the Satellite Meeting of the First Youth Academic Annual Conference of China Association for Science and Technology, Shenyang, China, 1992. Z Liu, C Liu, S Wang, Y Wang, and Q Liu, Radionuclide detecting portal-system shunt in cirrhosis, Proceedings of the Fourth Academic Meeting of the Chinese Society of Nuclear Medicine, p. 57, Wuhan, China, 1993. Z Liu, Y Wang, and Q Liu, Quantitative measurement of portal-system shunt in cirrhosis by radionuclide imaging, Proceedings of the World Chinese Conference of Nuclear Medicine, p. 34, Wuxi, China, 1993. Z Liu, Y Xia, Y Zhang, and Z Pei, Establishment and administration of the nuclear medicine department in the third class grade-A hospital, Seventh Academic Conference of Liaoning Chapter of the Chinese Society of Nuclear Medicine, Anshan, China, 1994. Z Liu, M Liu, and B Dai, The labeling and biodistribution of monoclonal antibodies with 186-Re for radioimmunotherapy, UICC XVI International Cancer Congress, India, 1994. G Johnson III, K N Nguyen, Z Liu, R Pasqualini, and R D Okada, Kinetics of 99mTcN-NOET from gamma camera images can identify ischemic myocardium at rest, J. Nucl. Medi., 37:107, 43rd Annual Meeting of the Society of Nuclear Medicine, Denver, Colorado, 1996. G Johnson III, K N Nguyen, Z Liu, P Gao, B Edwards, C M Archer, A C King, T L North, and R D Okada, HL91-Tc-99m: kinetics of a new hypoxia valid imaging agent in normal and ischemic myocardium as assessed by gamma camera images, J. Am. Coll. Cardiol., 27:2 (Supplement A): p. 407A, 45th Annual Scientific Sessions of the American College of Cardiology, Orlando, Florida, 1996. G Johnson III, K N Nguyen, Z Liu, P Gao, B Edwards, C M Archer, and R D Okada, HL91- Tc-99m: kinetics of a potential new viability marker in normal and infarcted myocardium as assessed by gamma camera imaging early after reperfusion, Circulation, 94:I-722, 69th Annual Scientific Sessions of the American Heart Association, New Orleans, Louisiana, 1996. G Johnson III, L R Carlson, K N Nguyen, Z Liu, P Gao, D Beju, and R D Okada, Concentration and time-dependent effects of cyanide on myocardium, FASEB Journal, 10:3, p. A326. Experimental Biology 96, Washington, D.C., 1996. G Johnson III, K N Nguyen, Z Liu, P Gao, A D Nunn, and R D Okada, Distribution of Tc-99m BMS194796 in normal and ischemic myocardium compared with tissue flow and oxygen, J. Nucl. Cardiol., 4:S64, The 3rd International Conference of Nuclear Cardiology, Florence, Italy, 1997. 8
  9. 9. G Johnson III, P Gao, Z Liu, K N Nguyen, and R D Okada, Relationship of Tc-99m-sestamibi kinetics and myocardial viability, J. Nucl. Medi., 38:5 (Supplement), 175 p., 44th Annual Meeting of the Society of Nuclear Medicine, San Antonio, Texas, 1997. G Johnson III, Z Liu, D Leung, D Beju, and R D Okada, Altered myocardial sestamibi kinetics can detect cardiotoxicity due to adriamycin treatment, FASEB Journal, 12:4, p. A73, Experimental Biology 98, San Francisco, California, 1998. D Beju, G Johnson III, Z Liu, D Leung, D Knox, D Yates, and R D Okada, Quantitation of mitochondrial injury in cardiomyocytes following adriamycin, FASEB Journal, 12:4, p. A342, Experimental Biology 98, San Francisco, California, 1998. G Johnson III, Z Liu, S Young, R Pasqualini, and R D Okada, Kinetics of technetium-99m-N- NOET in ischemia and hypoxia, J. Molec. and Cell. Cardiol., 30(7), p. A236, International Meeting of Molecular and Cellular Cardiology, Ann Arbor, Michigan, 1998. G Johnson III, Z Liu, and R D Okada, Myocardial kinetics of 99mTc-sestamibi retention in reperfusion injury, J. Molec. and Cell. Cardiol., 30(7), p. A236, International Meeting of Molecular and Cellular Cardiology, Ann Arbor, Michigan, 1998. Z Liu, M Liu, and J Lu, Tumor detection and localization using 186-Rhenium labeled immunotoxin, The Seventh Conference on Radioimmunodetection and Radioimmunotherapy of Cancer, 1998. Z Liu, M Liu, and J Lu, Antitumor effects of 186-Rhenium-labeled Trichosanthin immunotoxin, The 17th UICC International Cancer Congress, Brazil, 1998. G Johnson III, Z Liu, B Edwards, and R D Okada, 99mTc-HL91 can detect hibernating myocardium, Conference on Pathophysiology of Stunning, Hibernation, and Preconditioning, Italy, 1998. Z Liu, G Johnson III, D Beju, and R D Okada, Myocardial kinetics of 99mTc-sestamibi, 99mTc- tetrofosmin, and 99mTc-Q12 in severe ischemia-reperfusion injury, J. Amer. Coll. of Cardiol., 33:2 (supplement A) p. 480A, The 48th Annual Scientific Session of the American College of Cardiology, New Orleans, Louisiana, 1999. Z Liu, G Johnson III, D Beju, R Pasqualini, and R D Okada, Comparison of 99mTcN-NOET, 99mTc- Teboroxime, and 201-Thallium in severely injured hearts, J. Nucl. Cardiol., 6:(1), Part 2 (supplement), p. S53, The 4th International Conference of the Society of Nuclear Cardiology, Greece, 1999. Z Liu, G Johnson III, D Beju, and R D Okada, Comparison of 99mTc-sestamibi, 99mTc-tetrofosmin, and 99mTc-Q12 in a model of acute hibernating myocardium, J. Nucl. Cardiol., 6:(1), Part 2 (supplement), p. S54, The 4th International Conference of the Society of Nuclear Cardiology, Greece, 1999. Z Liu, G Johnson III, D Beju, R Pasqualini, and R D Okada, 99mTc-NOET, 99mTc-Teboroxime, and 201-Thallium kinetics in an acute model of stunned myocardium, FASEB Journal, A760, 598.2, Experimental Biology 99, Washington, D.C., 1999. 9
  10. 10. Z Liu, G Johnson III, D Beju, and R D Okada, Comparison of monocationic radiotracer kinetics in hearts exposed to brief ischemia and reperfusion, FASEB Journal, A760, 598.4, Experimental Biology 99, Washington, D.C., 1999. Z Liu, G. Johnson III, D Beju, B A Khaw, K Y Pak, and R D Okada, 99mTc-glucarate can detect myocardial necrosis early after injury due to severe ischemia with reperfusion, J. Nucl. Medi., 40:5 (supplement), 180 p., No. 815, The 46th Annual Meeting of the Society of Nuclear Medicine, Los Angeles, California, 1999. G Johnson, Z Liu, and R D Okada, 99mTc-HL91 (Prognox TM) trapped in hypoxic myocardium during low flow ischemia is rapidly released during reperfusion, J. Nucl. Medi., 0:5 (supplement), 180 p., No. 813, The 46th Annual Meeting of the Society of Nuclear Medicine, Los Angeles, California, 1999. G Johnson III, Z Liu, D Beju, and R D Okada, Kinetics of 99mTechnetium-HL91 (Prognox TM) can differentiate hibernating from stunned and normal myocardium, Circulation, Supplement 1:100 (18); I-864, The 72nd Annual Scientific Sessions of the American Heart Association, Atlanta, Georgia, 1999. Z Liu, G Johnson III, C L Hart, M W Eaton, C J Higgins, D R Okada, and R D Okada, PrognoxTM (99mTechnetium-HL91) can identify hypoxic viable regions in ischemic-reperfused myocardium with infarct, J. Amer. Coll. Cardiol,. 35 (supplement A):911-6, 493A, 49th Annual Scientific Session of the American College of Cardiology, Anaheim, California, 2000. G Johnson III, Z Liu, D Beju, R Pasqualini, and R D Okada, Kinetics of 99mTcN-NOET, 99mTc- Teboroxime, and 201-Thallium in acute hibernating myocardium, FASEB Journal, 14(4):481.5, A683, Experimental Biology 2000, San Diego, California, 2000. G Johnson III, Z Liu, D Beju, and R D Okada, Kinetics of 99mTc-Hl91 (PrognoxTM) in hibernating and ischemic-reperfused myocardium, FASEB Journal, 14(4):481.6, A683, Experimental Biology 2000, San Diego, California, 2000. D Beju, C J Higgins, G Johnson, Z Liu, and R D Okada, Mitochondria exhibit morphologic alterations following myocardial stunning, hibernation, and severe ischemia with reperfusion, FASEB Journal, 14(4):481.7, A683, Experimental Biology 2000, San Diego, California, 2000. G Johnson III, Z Liu, C L Hart, C J Higgins, M W Eaton, and R D Okada, Selective detection of infarct in myocardium with residual ischemia using 99mTc-Glucarate (AmiscanTM), J. Nucl. Medi., 41:5 (supplement), No. 784, 47th Annual Meeting of the Society of Nuclear Medicine, St. Louis, Missouri, 2000. Z Liu, G Johnson III, D Beju, and R D Okada, Kinetic properties of 99mTc-BRU796 can detect hibernating versus control and stunned myocardium, J. Nucl. Medi., 41:5 (supplement), No. 785, 47th Annual Meeting of the Society of Nuclear Medicine, St. Louis, Missouri, 2000. 10
  11. 11. G Johnson III, Z Liu, C J Higgins, D R Okada, R Pasqualini, R D Okada, Influence of blood interactions and circulation time on myocardial extraction of 99mTc-N-NOET in perfused hearts, Circulation, Supplement II:102 (18), II-546, Scientific Sessions 2000 of the American Heart Association, New Orleans, Louisiana, 2000. G Johnson III, Z Liu, D Beju, K Y Pak, B A Khaw, and R D Okada, Kinetics of 99mTc-glucarate in stunned, hibernating, and ischemic-reperfused myocardium with infarct, Circulation, Supplement II:102 (18), II-728, Scientific Sessions 2000 of the American Heart Association, New Orleans, Louisiana, 2000. Z Liu, G Johnson III, C L Hart, M W Eaton, R Pasqualini, and R D Okada, Myocardial distribution of 99mTcN-NOET following occlusion and reperfusion with residual ischemia and necrosis, J. Amer. Coll. Cardiol., 37(2) (supplement A):1175-140, 412A, 50th Annual Scientific Session of American College of Cardiology, Orlando, Florida, 2001. G Johnson III, Z Liu, C L Hart, M W Eaton, B A Khaw, K Y Pak, and R D Okada, Selective detection of infarct in reperfused myocardium using 99mTc-Glucarate, J. Nucl. Medi., 42:5 (supplement), No. 715, 164 p., 48th Annual Meeting of the Society of Nuclear Medicine, Toronto, Canada, 2001. G Johnson III, Z Liu, C J Higgins, D R Okada, B A Khaw, K Y Pak, S D Hocherman, and R D Okada, Myocardial kinetics of 99mTc-glucarate in ischemia, hypoxia, and aglycemia, J. Nucl. Medi., 42:5 (supplement), No. 716, 164 p., 48th Annual Meeting of the Society of Nuclear Medicine, Toronto, Canada, 2001. Z Liu, G A Kastis, G D Stevenson, H H Barrett, L R Furenlid, M A Kupinski, D R Patton, and D W Wilson, Quantitative analysis of acute myocardial infarction in rats using a high-resolution stationary SPECT system, Hires 2001 Abstracts, #227, 313: High-Resolution Imaging in Small Animals, Instrumentation, Applications and Animal Handling, Rockville, Maryland, 2001. Z Liu, G A Kastis, G D Stevenson, H H Barrett, LR Furenlid, D W Wilson, and K Y Pak, Measurement of acute myocardial infarction in rats: 99mTc-glucarate “hot spots” imaging with a high- resolution stationary SPECT system, Circulation, Supplement II:104 (17), II-586, Scientific Sessions 2001 of the American Heart Association, Anaheim, California, 2001. Z Liu, G D Stevenson, G A Kastis, H H Barrett, L R Furenlid, D W Wilson, J M Woolfenden, and K Y Pak, 99mTc-glucarate: detecting human breast tumor in SCID mice with high-resolution FastSPECT imaging, J. Nucl. Medi., 43:5 (supplement), No. 1104, 273 p., 49th Annual Meeting of the Society of Nuclear Medicine, Los Angeles, California, 2002. Z Liu, G A Kastis, G D Stevenson, H H Barrett, L R Furenlid, D W Wilson, and J M Woolfenden, In vivo identification of multidrug resistance in human breast tumor with 99mTc-labeled sestamibi and furifosmin, J. Nucl. Medi., 43:5 (supplement), No. 1119, 277 p., 49th Annual Meeting of the Society of Nuclear Medicine, Los Angeles, California, 2002. 11
  12. 12. Z Liu, G A Kastis, G D Stevenson, H H Barrett, L R Furenlid, D W Wilson, and J M Woolfenden, Application of high-resolution SPECT system, FastSPECT, in detecting myocardial ischemia and ischemia-reperfusion injury in rats, J. Nucl. Medi., 43:5 (supplement), No. 175, 48 p., 49th Annual Meeting of the Society of Nuclear Medicine, Los Angeles, California, 2002. Z Liu, G A Kastis, G D Stevenson, H H Barrett, M Bettan, L R Furenlid, D W Wilson, and K Y Pak, High-resolution imaging with 99mTc-labeled glucarate for assessment of myocardial infarcts in rat models exposed to different durations of ischemia followed by reperfusion, J. Nucl. Cardiol., 9(4):S10, 7th Annual Scientific Session and Symposium of the American Society of Nuclear Cardiology, Baltimore, Maryland, 2002. Zinn K R, G A Kastis, T R Chaudhuri, M Bettan, Z Cao, Z Liu, C Howison, G Stevenson, L Furenlid, and H H Barrett, Ultra-high resolution SPECT detects areas of ad-mediated human type 2 Somatostatin receptor (hSSTr2) expression within xenograft tumors in live mice, Annual Meeting of the Academy of Molecular Imaging, 2002. Z Liu, G D Stevenson, H H Barrett, G A Kastis, M Bettan, L R Furenlid, D W Wilson, and J M Woolfenden, Imaging recognition of multidrug resistance in human breast tumor using 99mTc-labeled monocationic agents and a high-resolution SPECT system, Proceedings of the 94th Annual Meeting of the American Association for Cancer Research, Volume 44:778, 2003. Z Liu, G D Stevenson, H H Barrett, G A Kastis, L R Furenlid, D W Wilson, M Bettan, and J M Woolfenden, Recognition of inhibition of multidrug resistance in human breast cancer xenografts using 99mTc-labeled sestamibi and tetrofosmin high-resolution SPECT imaging, J. Nucl. Medi., 44:5 (supplement), No. 1307, 366 p., The Society of Nuclear Medicine 50th Annual Meeting, New Orleans, Louisiana, 2003. Z Liu, H H Barrett, J M Woolfenden, G A Kastis, G Stevenson, L R Furenlid, D W Wilson, and K Y Pak, Ischemic preconditioning in the rat hearts: high-resolution SPECT imaging with 99mTc- labeled glucarate, J. Nucl. Medi., 44:5 (supplement), No. 705, 191 p., The Society of Nuclear Medicine 50th Annual Meeting, New Orleans, Louisiana, 2003. L R Furenlid, Y Chen, D W Wilson, A Lehovich, H Kim, G Stevenson, L Fesler, Z Liu, D D Patton, and H H Barrett, FastSPECT II: first static and dynamic images from a new high-resolution small-animal SPECT imager, J. Nucl. Medi., 44:5 (supplement), No. 525, 161 p., The Society of Nuclear Medicine 50th Annual Meeting, New Orleans, Louisiana, 2003. Z Liu, G D Stevenson, H H Barrett, G A Kastis, L R Furenlid, and D W Wilson, 99mTc-glucarate can detect breast tumor with multidrug resistance: high-resolution SPECT imaging study in SCID mice with tumor xenografts, Molec. Imag. and Biol., 5(3):159-160, The International Conference of the Academy of Molecular Imaging, Madrid, Spain, 2003. J M Woolfenden and Z Liu, Biomedical Significance of Small-Animal Imaging, Workshop on Small- Animal SPECT, Tucson, Arizona, January 14-16, 2004. 12
  13. 13. Z Liu, H H Barrett, G D Stevenson, L R Furenlid, D W Wilson, J M Woolfenden, and K Y Pak, Sequential imaging in rat hearts with 99mTc-teboroxime and 99mTc-glucarate, Symposium on Cardiovascular Molecular Imaging, Bethesda, Maryland, 2004. Z Liu, G D Stevenson, H H Barrett, L R Furenlid, D W Wilson, J M Woolfenden, and K Y Pak, Technetium-99m-glucarate imaging of human lung cancer xenografts in SCID mice, Molecular Imaging, 3(3):262, The Third Annual Meeting of the Society for Molecular Imaging, St. Louis, Missouri, 2004. Z Liu, G D Stevenson, H H Barrett, L R Furenlid, D W Wilson, and J M Woolfenden, Imaging recognition of inhibition of multidrug resistance in human breast cancer xenografts using 99mTc- labeled monocationic agents, Molecular Imaging, 3(3):263, The Third Annual Meeting of the Society for Molecular Imaging, St. Louis, Missouri, 2004. Z Liu, H H. Barrett, and K Y Pak, Evaluation of myocardial preconditioning and adenosine effects in cardioprotection in rat hearts with ischemia-reperfusion injury using 99mTc-glucarate imaging, The 8th Asia and Oceania Congress of Nuclear Medicine and Biology, Beijing, China, 2004. Z Liu, G D Stevenson, H H Barrett, L R Furenlid, D W Wilson, J M Woolfenden, and K Y Pak, Targeting of human lung cancer xenografts with technetium-99m-glucarate, J. Nucl. Med., 46(5) (Supplement 2), No. 574, p. 199, The Society of Nuclear Medicine 52nd Annual Meeting, Toronto, Ontario, Canada, 2005. L R Furenlid, H Kim, D W Wilson, Y-C Chen, Z Liu, G D Stevenson, H B Barber, H H Barrett, and J M Woolfenden, Preliminary comparison of small-animal SPECT systems based on scintillators and pixellated cadmium zinc telluride arrays, J. Nucl. Med., 46(5) (Supplement 2), No. 490, p. 170, The Society of Nuclear Medicine’s 52nd Annual Meeting, Toronto, Ontario, Canada, 2005. Z Liu, G D Stevenson, H H Barrett, L R Furenlid, D W Wilson, J M Woolfenden, and K Y Pak, Kinetic study of 99mTc-sestamibi imaging in xenografted human lung and breast cancer, Molec. Imag., 4(3) 243, Fourth Annual Meeting of the Society of Molecular Imaging, Cologne, Germany, 2005. Z Liu, J M Woolfenden, L R Furenlid, Y Chen, G D Stevenson, and H H Barrett, Application of FastSPECT II, a new version of FastSPECT, in detecting myocardial ischemia-reperfusion injury in rats, Molec. Imag., 4(3) 259, Fourth Annual Meeting of the Society of Molecular Imaging, Cologne, Germany, 2005. Z Liu, G Stevenson, Y Chen, L R Furenlid, H H Barrett, and J M Woolfenden, Characterization of doxorubicin-induced cardiotoxicity in rat hearts by 99mTc-sestamibi imaging, Mole. Imag. Biol., 8:92, Annual Conference of the Academy of Molecular Imaging, Orlando, Florida, 2006. Z Liu, Y Chen, G Stevenson, L R Furenlid, H H Barrett, and J M Woolfenden, Dynamic tomographic myocardial perfusion imaging with list-mode acquisition in mice using a novel small- animal SPECT system, J. Nucl. Med., 47(5) (Supplement 1), No. 1068, p. 253, 53rd Annual Meeting of the Society of Nuclear Medicine, San Diego, California, 2006. 13
  14. 14. Z Liu, L R Furenlid, Y Chen, G Stevenson, H H Barrett, and J M Woolfenden, Evaluating cardioprotective effect of melatonin in ischemic-reperfused rat hearts by 99mTc-tetrofosmin SPECT imaging, J. Nucl. Med., 47(5) (Supplement 1), No. 194, p. 68, 53rd Annual Meeting of the Society of Nuclear Medicine, San Diego, California, 2006. Z Liu, G Stevenson, L R Furenlid, H H Barrett, and J M Woolfenden, In vivo imaging study of insulin and fructose effects on technetium-99m-glucarate uptake in human lung cancer xenografts, Fifth Annual Meeting of the Society of Molecular Imaging, Big Island, Hawaii, 2006. Z Liu, Y Kim, S Liu, L R Furenlid, C Barber, G Stevenson, J W Woolfenden, and H H Barrett, Rapid myocardial perfusion imaging in rat hearts with a novel cationic 99mTc(I)-tricarbonyl complex 99m Tc-15C5PNP characterized by low liver uptake, J. Nucl. Med., 48(6) (Supplement 2), No. 15, p. 5, 54th Annual Meeting of the Society of Nuclear Medicine, Washington, DC, 2007. Z Liu, M M Hui, L R Furenlid, S Lewis, J M Woolfenden and H H Barrett, A novel 99mTc-labeled recombinant bispecific ligand targeting Interleukin-1 and Interleukin-18 for inflammation imaging, J. Nucl. Med., 48(6) (Supplement 2), No. 611, p. 180, 54th Annual Meeting of the Society of Nuclear Medicine, Washington, DC, 2007. M Zhao, Z Liu, X Zhu, L R Furenlid, Y-C Chen, and H H Barrett, In vivo dynamic imaging of myocardial cell death using 99mTc-labeled C2A domain of Synaptotagmin I in a rat model of ischemia and reperfusion, J. Nucl. Med., 48(6) (Supplement 2), No. 563, p. 166, 54th Annual Meeting of the Society of Nuclear Medicine, Washington, DC, 2007. Z Liu, M M Hui, L R Furenlid, C Barber, S A Lewis, J M Woolfenden, and H H Barrett, SPECT imaging of inflammation induced by myocardial ischemia-reperfusion with a novel 99mTc-labeled bispecific interleukin ligand, Abstract Book of Joint Molecular Imaging 2007 Conference, No. 0737, p. 263, Joint Molecular Imaging Conference, Providence, Rhode Island, 2007. Z Liu and M M Hui, Imaging of inflammation with 99mTc-labeled cytokine ligands, 3rd Biennial Workshop on Small-Animal SPECT Imaging, Tucson, Arizona, 2008. Z Liu, M M Hui, J M Woolfenden, and H H Barrett, A bispecific radioligand for inflammation imaging via TNF and IL-1 pathways, Accepted, 55th Annual Meeting of the Society of Nuclear Medicine, New Orleans, Louisiana, 2008. H H Barrett, Z Liu, L R Furenlid, J M Woolfenden, M Murphy, C Coleman, and F Barry, Tracking of mesenchymal stem cells via three transplantation routes in rats with myocardial infarction, Accepted, 55th Annual Meeting of the Society of Nuclear Medicine, New Orleans, Louisiana, 2008. Z Liu, M M Hui, G D Stevenson, and H H Barrett, Imaging of colon cancer xenografts using a radioligand targeting IL-1 and IL-18, Accepted, 55th Annual Meeting of the Society of Nuclear Medicine, New Orleans, Louisiana, 2008. 14
  15. 15. INVITED TALKS Z Liu, Detection of myocardial viability in ischemic-reperfused rat hearts with 99mTc sestamibi, Annual International Cardiolite Workshop (a user-meeting) at the Society of Nuclear Medicine Annual Meeting in New Orleans, Louisiana, June 23, 2003. H H Barrett and Z Liu, Recent advances in small-animal SPECT, with application to cardiac imaging, Proceedings of Symposium on Cardiovascular Molecular Imaging, pp. 95-100, Bethesda, Maryland, 2004. Z Liu, G D Stevenson, L R Furenlid, and H H Barrett, Small-animal models and MicroSPECT imaging, Animal Molecular Image International Symposium, Taipei, Taiwan, 2005. Z Liu, Small-animal SPECT imaging, Beijing Institute of Microbiology and Immunology, Beijing, China, 2007. Z Liu, Small-animal SPECT and molecular imaging, Harbin Medical University, Harbin, China, 2008. 15

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