Synapses

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Done by: Sebastián Díaz, Cindy Nuñez and Marianela Perroni. IFD Paysandú, 4th. form

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Synapses

  1. 1. Synapses<br />Synapse is a specialized point of functional contact between neurons or between a neuron and a target organ, that allows neurons to communicate with one another or with their target cells.<br />
  2. 2. Synapses<br />Three elements:<br /><ul><li>Presynaptic nerve terminal
  3. 3. Postsynaptic element
  4. 4. Synaptic cleft</li></li></ul><li>
  5. 5.
  6. 6.
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  8. 8. Common presynaptic arrangements:<br /><ul><li>Axon terminal branches have terminal enlargements (called boutons or bulbs)
  9. 9. Axon terminal branches feature varicosities (for synapses “in passing”)
  10. 10. Neuromuscular synapse: axon branches have terminal ramifications that form motor end plates on skeletal muscle fibres.</li></li></ul><li>Classification of synaptic types:<br /><ul><li>Axon dendritic: axon terminal branch (presynaptic element) synapses on a dendrite.
  11. 11. Axosomatic: axon terminal branch synapses on a soma (cell body).
  12. 12. Axoaxonic: axon terminal branch synapses on another axon terminal branch (for presynaptic inhibition) or beside the initial segment of an axon.
  13. 13. Dendrodendritic: dendrite synapsing on another dendrite (very localized effect).</li></li></ul><li>Synaptic ultrastructure:<br />Presynaptic enlargement<br />Contains synaptic vesicles clustered around an electron dense active zone. Vesicles are anchored in place by actin microfilaments. <br />
  14. 14. Pre and postsynaptic plasma membranes<br />Separated by a synaptic cleft<br /> contains glycoprotein linking<br /> material.<br />Surrounded by glial cell processes.<br />
  15. 15. Postsynaptic plasma membrane <br /> may appear remarkable <br /> or thickened<br />Receptor proteins<br />Embedded in<br />
  16. 16. Video<br />
  17. 17. Bibliography<br />Neurohistology II<br />http://vanat.cvm.umn.edu/NeuroLectPDFs/NeurohistologyLectII.pdf<br />

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