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Dominan Follicle selection in ovary
 

Dominan Follicle selection in ovary

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  • Suppression of plasma FSH in response to increased estradiol secretion by the dominant follicledecline in FSH support decreases aromatase activity and estradiol production and interrupts granulosa cell proliferation in those nondominant follicles

Dominan Follicle selection in ovary Dominan Follicle selection in ovary Presentation Transcript

  • Dr SIVARAJ SDEPT OF PHYSIOLOGYALL INDIA INSTITUTE OF MEDICAL SCIENCESNEW DELHI20/03/2013
  •  The mechanisms that trigger initiation offollicular growth are still not completelyunderstood Thought to involve bidirectionalcommunication between germ and somaticcells through gap junctions Paracrine factors : cytokines and growthfactors (insulin-like growth factor [IGF],epidermal and fibroblast growth factors, andinterleukin-1).Lange endocrine physiology 2ed
  •  FSH and insulin-like-growth factor (IGF)enhance each others ability tostimulate follicle cell function Access of IGF II to their receptors isregulated by IGF binding proteins and specificproteases ascribed a role in DF developmentSon WY et al. 2011
  •  Serum AMH level correlates with ovarianfollicle number AMH levels decline as the size of the follicleincreases In patients with polycystic ovary syndrome(PCOS), AMH levels are elevated, Potential relevance in PCOS diagnosis andmanagement A useful clinical marker for the assessment ofovarian reserveBroekmans FJ et al.2008
  • Aromatase and EstradiolEstradiol by DFGranulosa cell proliferation innon DFDF= Dominant follicleFSH in blood
  •  Healthy blood supply Accumulation of follicular fluid Increased density of FSH receptors on itsgranulosa cells Accumulation of atretogenic androgens,suchas DHT in the non DF
  •  As the DF grows vascularization of the thecalayer increases More efficient delivery of cholesterol to thecacells and better exposure to circulatinggonadotropins