SlideShare a Scribd company logo
1 of 13
Download to read offline
Dr. Ayaz Lone
 Decreased Production:
 Nutritional Deficiencies
 B12, Folate
 Bone marrow failure
 Aplastic anaemia
 Bone marrow infiltrations
 Leukaemia
 Metastasis
 Granulomatous disease
 Ineffective haematopoiesis
 Myelodysplastic syndromes
 Selective Impairment
 Drud induced (alcohol, Thiazides, cytotoxic)
 Infections ( Measles, HIV)
 Sequestration
 Hypersplenism
 Decreased Survival:
 Immunological destruction
 Primary autoimmune
 Acute ITP
 Chronic ITP
 Secondary Autoimmune
 SLE
 Alloimmune
 Post transfusion
 Neonatal
 Drug associated
 Quinidine, heparin, Sulfa compounds
 Infections
 HIV, Dengue fever, Infectious mononucleosis
 Nonimmunologic
 DIC
 TTP
 Giant haemangiomas
 Dilutional
 Massive transfussions
 Autoimmune disorder in which platelet
sensitization by autoantibodies takes
place, leading to destruction of opsonized
platelets primarily by the mononuclear
phagocytic system.
 Primary:
 Acute
 Chronic
 Secondary:
 Lymphoproliferative disorders
 SLE
 HIV
 Evan’s syndrome
 Thrombocytopenia in ITP is mediated by anti-
platelet antibodies directed against the
platelet specific glycoproteins (GP) IIb-
IIIa, Ib-IX or Ia-IIa.
 Antibodies against viral protein antigen that
are cross reactive against platelet antigens.
 Antibody coated platelets are susceptible to
phagocytosis by the cells of the mononuclear
phagocytic system.
 Spleen plays a crucial role for 2 reasons;
 Anti-platelet antibody production site
 Destruction of sensitized platelet
 IgG
 Petechiae
 Easy bruising
 Epistaxis
 Bleeding gums
 Melena
 Hematuria
 A diagnosis of ITP should be made only
after other causes of platelet deficiences
have been ruled out.
 CBC:
 Anaemia
 Thrombocytopenia
 BT
 Coagulation studies
 Bone marrow examination:
 Megakaryocytic hyperplasia with both mature
and maturing forms increased.

More Related Content

What's hot

What's hot (20)

Renal amyloidosis
Renal amyloidosisRenal amyloidosis
Renal amyloidosis
 
Chronic cholecystitis & Jaundice
Chronic cholecystitis & JaundiceChronic cholecystitis & Jaundice
Chronic cholecystitis & Jaundice
 
Chylothorax and chyloptysis
Chylothorax and chyloptysisChylothorax and chyloptysis
Chylothorax and chyloptysis
 
Upper Gastrointestinal bleeding
Upper Gastrointestinal bleedingUpper Gastrointestinal bleeding
Upper Gastrointestinal bleeding
 
granulomatosis with polyangiitis (Wegener’s granulomatosis)
granulomatosis with polyangiitis (Wegener’s granulomatosis) granulomatosis with polyangiitis (Wegener’s granulomatosis)
granulomatosis with polyangiitis (Wegener’s granulomatosis)
 
Pneumonia
PneumoniaPneumonia
Pneumonia
 
Hiv associated nephropathy(Dr. sood)
Hiv associated nephropathy(Dr. sood)Hiv associated nephropathy(Dr. sood)
Hiv associated nephropathy(Dr. sood)
 
Dyspepsia
Dyspepsia Dyspepsia
Dyspepsia
 
Acute diarrhoea
Acute diarrhoeaAcute diarrhoea
Acute diarrhoea
 
Chronic hepatitis ppt
Chronic hepatitis pptChronic hepatitis ppt
Chronic hepatitis ppt
 
Respiratory failure
Respiratory failureRespiratory failure
Respiratory failure
 
Autoimmune hepatitis better understanding (2)
Autoimmune hepatitis better understanding (2)Autoimmune hepatitis better understanding (2)
Autoimmune hepatitis better understanding (2)
 
Hemolytic uremic Syndrome
Hemolytic uremic SyndromeHemolytic uremic Syndrome
Hemolytic uremic Syndrome
 
Oesophagus – perforation, mallory weiss syndrome and
Oesophagus – perforation, mallory weiss syndrome andOesophagus – perforation, mallory weiss syndrome and
Oesophagus – perforation, mallory weiss syndrome and
 
500 single best answers in medicine
500 single best answers in medicine500 single best answers in medicine
500 single best answers in medicine
 
Pulmonary fibrosis
Pulmonary fibrosis   Pulmonary fibrosis
Pulmonary fibrosis
 
Vasculitis
VasculitisVasculitis
Vasculitis
 
Pneumonia
PneumoniaPneumonia
Pneumonia
 
10.Pneumothorax
10.Pneumothorax10.Pneumothorax
10.Pneumothorax
 
Fulminant hepatic failure (fhf)
Fulminant hepatic failure (fhf)Fulminant hepatic failure (fhf)
Fulminant hepatic failure (fhf)
 

Viewers also liked

Viewers also liked (8)

Thrombocytopenia
ThrombocytopeniaThrombocytopenia
Thrombocytopenia
 
Thrombocytopenia
ThrombocytopeniaThrombocytopenia
Thrombocytopenia
 
Thrombocytopenia
ThrombocytopeniaThrombocytopenia
Thrombocytopenia
 
Thrombocytopenia
ThrombocytopeniaThrombocytopenia
Thrombocytopenia
 
Thrombocytopenia
ThrombocytopeniaThrombocytopenia
Thrombocytopenia
 
An approach to a patient with Thrombocytopenia
An approach to a patient with ThrombocytopeniaAn approach to a patient with Thrombocytopenia
An approach to a patient with Thrombocytopenia
 
CME thrombocytopenia
CME thrombocytopeniaCME thrombocytopenia
CME thrombocytopenia
 
Thrombocytopenia
Thrombocytopenia Thrombocytopenia
Thrombocytopenia
 

Similar to Thrombocytopenia

immundeficiencydiseases-160925065412.pdf
immundeficiencydiseases-160925065412.pdfimmundeficiencydiseases-160925065412.pdf
immundeficiencydiseases-160925065412.pdfNadiirMahamoud
 
Immunodeficiency diseases
Immunodeficiency diseasesImmunodeficiency diseases
Immunodeficiency diseasesRAJESH KUMAR
 
HIV Manifestations
HIV ManifestationsHIV Manifestations
HIV ManifestationsM S
 
Congenital and Acquired Immunodeficiency
Congenital and Acquired ImmunodeficiencyCongenital and Acquired Immunodeficiency
Congenital and Acquired ImmunodeficiencyGifteeJRoumi
 
Immunodeficiency_DISORDERS.pptx.........
Immunodeficiency_DISORDERS.pptx.........Immunodeficiency_DISORDERS.pptx.........
Immunodeficiency_DISORDERS.pptx.........samwel18
 
Immunodeficiency - SCID & LAD
Immunodeficiency - SCID & LADImmunodeficiency - SCID & LAD
Immunodeficiency - SCID & LADApoorva Rajagopal
 
Diseases of the Immune System
Diseases of the Immune SystemDiseases of the Immune System
Diseases of the Immune SystemGhie Santos
 
-immunopathology-2.ppt
-immunopathology-2.ppt-immunopathology-2.ppt
-immunopathology-2.pptGowthun
 
Immunology xi immunodeficiency
Immunology xi immunodeficiencyImmunology xi immunodeficiency
Immunology xi immunodeficiencyMUBOSScz
 
106117.pptx
106117.pptx106117.pptx
106117.pptxAnnSabu5
 
Cns infections biplave nams
Cns infections biplave namsCns infections biplave nams
Cns infections biplave namsbiplave karki
 
Immunodeficiency disease by Dr. Rakesh Prasad Sah
Immunodeficiency disease by Dr. Rakesh Prasad SahImmunodeficiency disease by Dr. Rakesh Prasad Sah
Immunodeficiency disease by Dr. Rakesh Prasad SahDr. Rakesh Prasad Sah
 
Complications of immunosuppression
Complications of immunosuppressionComplications of immunosuppression
Complications of immunosuppressionSharath !!!!!!!!
 
Macrophage in Health and Disease.ppt
Macrophage in Health and Disease.pptMacrophage in Health and Disease.ppt
Macrophage in Health and Disease.pptdrnikhilningurkar1
 

Similar to Thrombocytopenia (20)

immundeficiencydiseases-160925065412.pdf
immundeficiencydiseases-160925065412.pdfimmundeficiencydiseases-160925065412.pdf
immundeficiencydiseases-160925065412.pdf
 
Immunodeficiency diseases
Immunodeficiency diseasesImmunodeficiency diseases
Immunodeficiency diseases
 
HIV Manifestations
HIV ManifestationsHIV Manifestations
HIV Manifestations
 
Amyloidosis 2
Amyloidosis 2Amyloidosis 2
Amyloidosis 2
 
Congenital and Acquired Immunodeficiency
Congenital and Acquired ImmunodeficiencyCongenital and Acquired Immunodeficiency
Congenital and Acquired Immunodeficiency
 
Immunodeficiency_DISORDERS.pptx.........
Immunodeficiency_DISORDERS.pptx.........Immunodeficiency_DISORDERS.pptx.........
Immunodeficiency_DISORDERS.pptx.........
 
Immunodeficiency - SCID & LAD
Immunodeficiency - SCID & LADImmunodeficiency - SCID & LAD
Immunodeficiency - SCID & LAD
 
Autoimmune
AutoimmuneAutoimmune
Autoimmune
 
Immunodeficiency Disorder
Immunodeficiency DisorderImmunodeficiency Disorder
Immunodeficiency Disorder
 
Diseases of the Immune System
Diseases of the Immune SystemDiseases of the Immune System
Diseases of the Immune System
 
-immunopathology-2.ppt
-immunopathology-2.ppt-immunopathology-2.ppt
-immunopathology-2.ppt
 
Immunology xi immunodeficiency
Immunology xi immunodeficiencyImmunology xi immunodeficiency
Immunology xi immunodeficiency
 
Autoimmunity.pptx
Autoimmunity.pptxAutoimmunity.pptx
Autoimmunity.pptx
 
106117.pptx
106117.pptx106117.pptx
106117.pptx
 
Immunodeficiency disorders,2010
Immunodeficiency disorders,2010Immunodeficiency disorders,2010
Immunodeficiency disorders,2010
 
HIV AIDS.pptx
HIV AIDS.pptxHIV AIDS.pptx
HIV AIDS.pptx
 
Cns infections biplave nams
Cns infections biplave namsCns infections biplave nams
Cns infections biplave nams
 
Immunodeficiency disease by Dr. Rakesh Prasad Sah
Immunodeficiency disease by Dr. Rakesh Prasad SahImmunodeficiency disease by Dr. Rakesh Prasad Sah
Immunodeficiency disease by Dr. Rakesh Prasad Sah
 
Complications of immunosuppression
Complications of immunosuppressionComplications of immunosuppression
Complications of immunosuppression
 
Macrophage in Health and Disease.ppt
Macrophage in Health and Disease.pptMacrophage in Health and Disease.ppt
Macrophage in Health and Disease.ppt
 

More from Atifa Ambreen

General and Cellular Morphology
General and Cellular MorphologyGeneral and Cellular Morphology
General and Cellular MorphologyAtifa Ambreen
 
Scope of Pharmaceutical microbiology -2021
Scope of Pharmaceutical microbiology -2021Scope of Pharmaceutical microbiology -2021
Scope of Pharmaceutical microbiology -2021Atifa Ambreen
 
Nomenclature and classification of microorganisms - 2021
Nomenclature and classification of microorganisms - 2021 Nomenclature and classification of microorganisms - 2021
Nomenclature and classification of microorganisms - 2021 Atifa Ambreen
 
Allergy and Hypersensitivity
Allergy and HypersensitivityAllergy and Hypersensitivity
Allergy and HypersensitivityAtifa Ambreen
 
Autoimmunity and Tolerance
Autoimmunity and ToleranceAutoimmunity and Tolerance
Autoimmunity and ToleranceAtifa Ambreen
 
Introduction of Biosafety
Introduction of BiosafetyIntroduction of Biosafety
Introduction of BiosafetyAtifa Ambreen
 
Antibodies and Types
Antibodies and TypesAntibodies and Types
Antibodies and TypesAtifa Ambreen
 
Introduction and types of immunity I Pharmaceutical Microbiology
Introduction and types of immunity I Pharmaceutical MicrobiologyIntroduction and types of immunity I Pharmaceutical Microbiology
Introduction and types of immunity I Pharmaceutical MicrobiologyAtifa Ambreen
 
Morphological and Selective Biochemical characterization of some specimen
Morphological and Selective Biochemical characterization of some specimenMorphological and Selective Biochemical characterization of some specimen
Morphological and Selective Biochemical characterization of some specimenAtifa Ambreen
 
Microbiology of Air, Water and Soil
Microbiology of Air, Water and SoilMicrobiology of Air, Water and Soil
Microbiology of Air, Water and SoilAtifa Ambreen
 
An Overview of Immunity to Viruses, Bacteria, Fungi and Ptozoans
An Overview of Immunity to Viruses, Bacteria, Fungi and PtozoansAn Overview of Immunity to Viruses, Bacteria, Fungi and Ptozoans
An Overview of Immunity to Viruses, Bacteria, Fungi and PtozoansAtifa Ambreen
 
An Overview of the Immune System
An Overview of the Immune SystemAn Overview of the Immune System
An Overview of the Immune SystemAtifa Ambreen
 
Major Histocompatibility Complex (MHC)
Major Histocompatibility Complex (MHC)Major Histocompatibility Complex (MHC)
Major Histocompatibility Complex (MHC)Atifa Ambreen
 
Factor affecting bacterial growth
Factor affecting bacterial growthFactor affecting bacterial growth
Factor affecting bacterial growthAtifa Ambreen
 
Cellular and molecular basis of immunity
Cellular and molecular basis of immunityCellular and molecular basis of immunity
Cellular and molecular basis of immunityAtifa Ambreen
 

More from Atifa Ambreen (20)

General and Cellular Morphology
General and Cellular MorphologyGeneral and Cellular Morphology
General and Cellular Morphology
 
Scope of Pharmaceutical microbiology -2021
Scope of Pharmaceutical microbiology -2021Scope of Pharmaceutical microbiology -2021
Scope of Pharmaceutical microbiology -2021
 
Nomenclature and classification of microorganisms - 2021
Nomenclature and classification of microorganisms - 2021 Nomenclature and classification of microorganisms - 2021
Nomenclature and classification of microorganisms - 2021
 
Allergy and Hypersensitivity
Allergy and HypersensitivityAllergy and Hypersensitivity
Allergy and Hypersensitivity
 
Autoimmunity and Tolerance
Autoimmunity and ToleranceAutoimmunity and Tolerance
Autoimmunity and Tolerance
 
Biosafety Levels
Biosafety LevelsBiosafety Levels
Biosafety Levels
 
Introduction of Biosafety
Introduction of BiosafetyIntroduction of Biosafety
Introduction of Biosafety
 
Antibodies and Types
Antibodies and TypesAntibodies and Types
Antibodies and Types
 
Introduction and types of immunity I Pharmaceutical Microbiology
Introduction and types of immunity I Pharmaceutical MicrobiologyIntroduction and types of immunity I Pharmaceutical Microbiology
Introduction and types of immunity I Pharmaceutical Microbiology
 
Morphological and Selective Biochemical characterization of some specimen
Morphological and Selective Biochemical characterization of some specimenMorphological and Selective Biochemical characterization of some specimen
Morphological and Selective Biochemical characterization of some specimen
 
Fungi/Yeast/Molds
Fungi/Yeast/MoldsFungi/Yeast/Molds
Fungi/Yeast/Molds
 
Normal Flora
Normal FloraNormal Flora
Normal Flora
 
Microbiology of Air, Water and Soil
Microbiology of Air, Water and SoilMicrobiology of Air, Water and Soil
Microbiology of Air, Water and Soil
 
Culture media
Culture mediaCulture media
Culture media
 
Bacterial Culture
Bacterial CultureBacterial Culture
Bacterial Culture
 
An Overview of Immunity to Viruses, Bacteria, Fungi and Ptozoans
An Overview of Immunity to Viruses, Bacteria, Fungi and PtozoansAn Overview of Immunity to Viruses, Bacteria, Fungi and Ptozoans
An Overview of Immunity to Viruses, Bacteria, Fungi and Ptozoans
 
An Overview of the Immune System
An Overview of the Immune SystemAn Overview of the Immune System
An Overview of the Immune System
 
Major Histocompatibility Complex (MHC)
Major Histocompatibility Complex (MHC)Major Histocompatibility Complex (MHC)
Major Histocompatibility Complex (MHC)
 
Factor affecting bacterial growth
Factor affecting bacterial growthFactor affecting bacterial growth
Factor affecting bacterial growth
 
Cellular and molecular basis of immunity
Cellular and molecular basis of immunityCellular and molecular basis of immunity
Cellular and molecular basis of immunity
 

Recently uploaded

INTRODUCTION TO THE FORENSIC SCIENCE.ppt
INTRODUCTION TO THE FORENSIC SCIENCE.pptINTRODUCTION TO THE FORENSIC SCIENCE.ppt
INTRODUCTION TO THE FORENSIC SCIENCE.pptKavitha Krishnan
 
TARGET DELINEATION IN RECTUM CANCER BY DR KANHU
TARGET DELINEATION IN RECTUM  CANCER BY DR KANHUTARGET DELINEATION IN RECTUM  CANCER BY DR KANHU
TARGET DELINEATION IN RECTUM CANCER BY DR KANHUKanhu Charan
 
Neutraceuticals, Herb-drug & Herb-food inetractions
Neutraceuticals, Herb-drug & Herb-food inetractionsNeutraceuticals, Herb-drug & Herb-food inetractions
Neutraceuticals, Herb-drug & Herb-food inetractionsPradnya Wadekar
 
TARGET DELINEATION IN CERVIX CANCER BY DR KANHU
TARGET DELINEATION IN CERVIX CANCER BY DR KANHUTARGET DELINEATION IN CERVIX CANCER BY DR KANHU
TARGET DELINEATION IN CERVIX CANCER BY DR KANHUKanhu Charan
 
clean rooms and its classification .pptx
clean rooms and its classification .pptxclean rooms and its classification .pptx
clean rooms and its classification .pptxushakiranmai4
 
ANATOMY OF CEREBELLUM With Clinical Anatomy.pptx
ANATOMY OF CEREBELLUM With Clinical Anatomy.pptxANATOMY OF CEREBELLUM With Clinical Anatomy.pptx
ANATOMY OF CEREBELLUM With Clinical Anatomy.pptxsiddharthroy26587
 
Ayurveda research in Hypothyroidism, P
Ayurveda  research  in Hypothyroidism, PAyurveda  research  in Hypothyroidism, P
Ayurveda research in Hypothyroidism, PDr.Shalu Jain
 
Reproductive and Child Health Services ppt.pptx
Reproductive and Child Health Services ppt.pptxReproductive and Child Health Services ppt.pptx
Reproductive and Child Health Services ppt.pptxVeereshDemashetti
 
EMBRYOLOGY AND FOETAL DEVELOPMENT-mayu.pdf
EMBRYOLOGY AND FOETAL DEVELOPMENT-mayu.pdfEMBRYOLOGY AND FOETAL DEVELOPMENT-mayu.pdf
EMBRYOLOGY AND FOETAL DEVELOPMENT-mayu.pdfMayuriGamit2
 
Basic of Thyroid Hormone:- An In-depth Analysis
Basic of Thyroid Hormone:- An In-depth AnalysisBasic of Thyroid Hormone:- An In-depth Analysis
Basic of Thyroid Hormone:- An In-depth AnalysisAshishMaletha2
 
Human Skeletal System_By Anupam Das......
Human Skeletal System_By Anupam Das......Human Skeletal System_By Anupam Das......
Human Skeletal System_By Anupam Das......anupamdas2143
 
Routine Medicine Laboratory Testing _ CÁC XÉT NGHIỆM THƯỜNG QUY ÁP DỤNG TRON...
Routine Medicine Laboratory Testing  _ CÁC XÉT NGHIỆM THƯỜNG QUY ÁP DỤNG TRON...Routine Medicine Laboratory Testing  _ CÁC XÉT NGHIỆM THƯỜNG QUY ÁP DỤNG TRON...
Routine Medicine Laboratory Testing _ CÁC XÉT NGHIỆM THƯỜNG QUY ÁP DỤNG TRON...DUY NGUYEN PHUC
 
Ovarian tumors Lecture notes for MBBS.pptx
Ovarian tumors Lecture notes for MBBS.pptxOvarian tumors Lecture notes for MBBS.pptx
Ovarian tumors Lecture notes for MBBS.pptxSizan Thapa
 
Ortho Products Franchise-solace biotech limited
Ortho Products Franchise-solace biotech limitedOrtho Products Franchise-solace biotech limited
Ortho Products Franchise-solace biotech limitedSBL DIGITAL
 
HDT Unit 2: Nutraceuticals Global Market Overview And Growth Of Nutraceutical...
HDT Unit 2: Nutraceuticals Global Market Overview And Growth Of Nutraceutical...HDT Unit 2: Nutraceuticals Global Market Overview And Growth Of Nutraceutical...
HDT Unit 2: Nutraceuticals Global Market Overview And Growth Of Nutraceutical...Genesis Institute of Pharmacy, Radhanagari.
 
bleeding disorders 1 Dr.Nannika Pradhan
bleeding disorders 1  Dr.Nannika Pradhanbleeding disorders 1  Dr.Nannika Pradhan
bleeding disorders 1 Dr.Nannika Pradhanthesalberry
 
Thyroid function tests for MBBS, LAB. MED & BDS.pptx
Thyroid function tests for MBBS, LAB. MED & BDS.pptxThyroid function tests for MBBS, LAB. MED & BDS.pptx
Thyroid function tests for MBBS, LAB. MED & BDS.pptxRajendra Dev Bhatt
 
Methicillin-resistant Staphylococcus Aureus (MRSA)
Methicillin-resistant Staphylococcus Aureus (MRSA)Methicillin-resistant Staphylococcus Aureus (MRSA)
Methicillin-resistant Staphylococcus Aureus (MRSA)Ahmad Thanin
 
CELL BLOCK PREPARATION AND ITS IMPORTANCE
CELL BLOCK PREPARATION AND ITS IMPORTANCECELL BLOCK PREPARATION AND ITS IMPORTANCE
CELL BLOCK PREPARATION AND ITS IMPORTANCEShubhadip Ghosh
 

Recently uploaded (20)

INTRODUCTION TO THE FORENSIC SCIENCE.ppt
INTRODUCTION TO THE FORENSIC SCIENCE.pptINTRODUCTION TO THE FORENSIC SCIENCE.ppt
INTRODUCTION TO THE FORENSIC SCIENCE.ppt
 
Oral disorders .pptx
Oral disorders .pptxOral disorders .pptx
Oral disorders .pptx
 
TARGET DELINEATION IN RECTUM CANCER BY DR KANHU
TARGET DELINEATION IN RECTUM  CANCER BY DR KANHUTARGET DELINEATION IN RECTUM  CANCER BY DR KANHU
TARGET DELINEATION IN RECTUM CANCER BY DR KANHU
 
Neutraceuticals, Herb-drug & Herb-food inetractions
Neutraceuticals, Herb-drug & Herb-food inetractionsNeutraceuticals, Herb-drug & Herb-food inetractions
Neutraceuticals, Herb-drug & Herb-food inetractions
 
TARGET DELINEATION IN CERVIX CANCER BY DR KANHU
TARGET DELINEATION IN CERVIX CANCER BY DR KANHUTARGET DELINEATION IN CERVIX CANCER BY DR KANHU
TARGET DELINEATION IN CERVIX CANCER BY DR KANHU
 
clean rooms and its classification .pptx
clean rooms and its classification .pptxclean rooms and its classification .pptx
clean rooms and its classification .pptx
 
ANATOMY OF CEREBELLUM With Clinical Anatomy.pptx
ANATOMY OF CEREBELLUM With Clinical Anatomy.pptxANATOMY OF CEREBELLUM With Clinical Anatomy.pptx
ANATOMY OF CEREBELLUM With Clinical Anatomy.pptx
 
Ayurveda research in Hypothyroidism, P
Ayurveda  research  in Hypothyroidism, PAyurveda  research  in Hypothyroidism, P
Ayurveda research in Hypothyroidism, P
 
Reproductive and Child Health Services ppt.pptx
Reproductive and Child Health Services ppt.pptxReproductive and Child Health Services ppt.pptx
Reproductive and Child Health Services ppt.pptx
 
EMBRYOLOGY AND FOETAL DEVELOPMENT-mayu.pdf
EMBRYOLOGY AND FOETAL DEVELOPMENT-mayu.pdfEMBRYOLOGY AND FOETAL DEVELOPMENT-mayu.pdf
EMBRYOLOGY AND FOETAL DEVELOPMENT-mayu.pdf
 
Basic of Thyroid Hormone:- An In-depth Analysis
Basic of Thyroid Hormone:- An In-depth AnalysisBasic of Thyroid Hormone:- An In-depth Analysis
Basic of Thyroid Hormone:- An In-depth Analysis
 
Human Skeletal System_By Anupam Das......
Human Skeletal System_By Anupam Das......Human Skeletal System_By Anupam Das......
Human Skeletal System_By Anupam Das......
 
Routine Medicine Laboratory Testing _ CÁC XÉT NGHIỆM THƯỜNG QUY ÁP DỤNG TRON...
Routine Medicine Laboratory Testing  _ CÁC XÉT NGHIỆM THƯỜNG QUY ÁP DỤNG TRON...Routine Medicine Laboratory Testing  _ CÁC XÉT NGHIỆM THƯỜNG QUY ÁP DỤNG TRON...
Routine Medicine Laboratory Testing _ CÁC XÉT NGHIỆM THƯỜNG QUY ÁP DỤNG TRON...
 
Ovarian tumors Lecture notes for MBBS.pptx
Ovarian tumors Lecture notes for MBBS.pptxOvarian tumors Lecture notes for MBBS.pptx
Ovarian tumors Lecture notes for MBBS.pptx
 
Ortho Products Franchise-solace biotech limited
Ortho Products Franchise-solace biotech limitedOrtho Products Franchise-solace biotech limited
Ortho Products Franchise-solace biotech limited
 
HDT Unit 2: Nutraceuticals Global Market Overview And Growth Of Nutraceutical...
HDT Unit 2: Nutraceuticals Global Market Overview And Growth Of Nutraceutical...HDT Unit 2: Nutraceuticals Global Market Overview And Growth Of Nutraceutical...
HDT Unit 2: Nutraceuticals Global Market Overview And Growth Of Nutraceutical...
 
bleeding disorders 1 Dr.Nannika Pradhan
bleeding disorders 1  Dr.Nannika Pradhanbleeding disorders 1  Dr.Nannika Pradhan
bleeding disorders 1 Dr.Nannika Pradhan
 
Thyroid function tests for MBBS, LAB. MED & BDS.pptx
Thyroid function tests for MBBS, LAB. MED & BDS.pptxThyroid function tests for MBBS, LAB. MED & BDS.pptx
Thyroid function tests for MBBS, LAB. MED & BDS.pptx
 
Methicillin-resistant Staphylococcus Aureus (MRSA)
Methicillin-resistant Staphylococcus Aureus (MRSA)Methicillin-resistant Staphylococcus Aureus (MRSA)
Methicillin-resistant Staphylococcus Aureus (MRSA)
 
CELL BLOCK PREPARATION AND ITS IMPORTANCE
CELL BLOCK PREPARATION AND ITS IMPORTANCECELL BLOCK PREPARATION AND ITS IMPORTANCE
CELL BLOCK PREPARATION AND ITS IMPORTANCE
 

Thrombocytopenia

  • 2.  Decreased Production:  Nutritional Deficiencies  B12, Folate  Bone marrow failure  Aplastic anaemia  Bone marrow infiltrations  Leukaemia  Metastasis  Granulomatous disease
  • 3.  Ineffective haematopoiesis  Myelodysplastic syndromes  Selective Impairment  Drud induced (alcohol, Thiazides, cytotoxic)  Infections ( Measles, HIV)  Sequestration  Hypersplenism
  • 4.  Decreased Survival:  Immunological destruction  Primary autoimmune  Acute ITP  Chronic ITP  Secondary Autoimmune  SLE
  • 5.  Alloimmune  Post transfusion  Neonatal  Drug associated  Quinidine, heparin, Sulfa compounds  Infections  HIV, Dengue fever, Infectious mononucleosis
  • 6.  Nonimmunologic  DIC  TTP  Giant haemangiomas  Dilutional  Massive transfussions
  • 7.  Autoimmune disorder in which platelet sensitization by autoantibodies takes place, leading to destruction of opsonized platelets primarily by the mononuclear phagocytic system.
  • 8.  Primary:  Acute  Chronic  Secondary:  Lymphoproliferative disorders  SLE  HIV  Evan’s syndrome
  • 9.  Thrombocytopenia in ITP is mediated by anti- platelet antibodies directed against the platelet specific glycoproteins (GP) IIb- IIIa, Ib-IX or Ia-IIa.  Antibodies against viral protein antigen that are cross reactive against platelet antigens.
  • 10.  Antibody coated platelets are susceptible to phagocytosis by the cells of the mononuclear phagocytic system.  Spleen plays a crucial role for 2 reasons;  Anti-platelet antibody production site  Destruction of sensitized platelet  IgG
  • 11.  Petechiae  Easy bruising  Epistaxis  Bleeding gums  Melena  Hematuria
  • 12.  A diagnosis of ITP should be made only after other causes of platelet deficiences have been ruled out.  CBC:  Anaemia  Thrombocytopenia  BT  Coagulation studies
  • 13.  Bone marrow examination:  Megakaryocytic hyperplasia with both mature and maturing forms increased.