QIS PHILS., INC.

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QIS PHILS., INC.

  1. 1. QIS Chemistry of OXINEPRESENTATION
  2. 2. QIS OXINEPRE CompositionS ]EN Characteristics Of Matter - OXINETA ]TI Chemical Reactions ]ON
  3. 3. QIS OXINEPR COMPOSITIONESENT CHARACTERISTICSATION CHEMICAL REACTIONS
  4. 4. OXINECOMPOSITION CHARACTERISTICS CHEMICAL REACTIONSChlorine Dioxide Disinfects Disinfecting ActivitySodium Chlorite Deodorizes Deodorizing ActivityOxychloro Species Sanitizes Sanitizing Activity Attacks Biofilms Attack of Biofilms Kills Microbes Antimicrobial Activity
  5. 5. QIS Composition of OXINEPR OXINE is a highly refined blendE of oxychloro species containingSE 3.35% purified sodium chloriteNT or 2.00-2.10 % availableA chlorine dioxideTION
  6. 6. QIS Composition of OXINEPR … highly refined…ESE * above minimum standard purityNT * then production process involvesA “a refining process”T one that removes impurities (undesirable substances)I to render the end-product with a high degree of purity.ON
  7. 7. QIS Composition of OXINEPR … blend …ESE combination of two or more substancesN which result in a homogeneous mixture .TA homogeneous - one phase only, components have no visibleT differing parts; the components are uniformly distributedI throughout the mixtureON
  8. 8. QIS Composition of OXINEP … Oxychloro …RE combination of Oxygen (oxy) andS Chlorine (chloro)EN … species …T groups having similar set of propertiesAT … Oxychloro species …I chemical groups containing oxygenO and chlorine, having similar set ofN properties
  9. 9. Q Oxychloro SpeciesIS CHEMICAL CHEMICAL PROPERTIES NAME FORMULAP Sodium chlorate NaClO3 used in the Solvay Process* to generate Chlorine dioxide.R Chlorate (ion) ClO3 - can be a minor component of the by-product of the reaction of chlorine dioxide.E Sodium chlorite NaClO2 the primary precursor to chlorine dioxide in use today.S Chlorite (ion) ClO2 – the primary by-product of the reaction of chlorine dioxideE with other compounds.N Chlorous acid HClO2 a weak acid that is intermediate in the reaction path between sodium chlorite and chlorine dioxide.T It is thought to have high antimicrobial activity, especiallyA when combined with chlorine dioxide itself.T Hypochlorite ClO- sometimes used in the generation of chlorine dioxide to drive the reaction as completely as possible towards theI production of chlorine dioxide.O Chlorine dioxide ClO2 generally regarded as the “active ingredient” in Oxine chemistry.N It is a powerful oxidizer and exists as a gaseous free radical in nature.
  10. 10. QIS OXINEP Oxine is a highly refined blend of oxychloro speciesR containing 3.35% purified sodium chloriteE or 2.00-2.10 % available chlorine dioxideSEN purified sodium chlorite + oxychloro speciesTA OXINE orTI available chlorine dioxide + oxychloro speciesON
  11. 11. OXINE TECHNICAL DATA SHEETQ CHEMICAL PRODUCTIS PRODUCT NAME CHEMICAL FAMILY : : Oxine Mixture of Oxychlorine Compounds E.P.A.REGISTRATION NUMBER: 9804-1P EFFECTIVE DATE : June 2004 SUPERSEDES : April 2002RE COMPOSITION / INFORMATION ON INGREDIENTSS Chemical Name C.A.S. No. % by Wt.E Sodium Chlorite 7758-19-2 3.35%N CONCENTRATE PROPERTIEST Concentration: 2.00 – 2.10 % available chlorine dioxideA Appearance: Colorless liquid pH Concentrate: of 8.2 – 8.5 Odor: Very faint chlorinous odor Boiling point: 213 oF (100.5 oC)T Melting point: N/A Freezing point: 28.9 oF (-1.72 oC)I Vapor Pressure: 23.7 mm Hg (25 oC) Vapor Density: 0.02 kg/m3O Specific Gravity: 1.03 g/ml (20 oC) Solubility in water: Complete Volatiles (by volume): 97% (Water) Evaporation rate: Comparable to waterN Very low acute toxicity (EPA Cat. III) Non-flammable, non explosive, stable solution NFPA Rating: Fire: 0 Health: 1 - Reactivity: 1 - Special: None
  12. 12. QIS Chlorine DioxidePRE Is chlorine dioxide theSE sole active ingredientNT in Oxine?ATION
  13. 13. Q Comparison of Solutions containing EqualI Concentrations of ClO2 against ListeriaS monocytogenes Scott AP Generated ActivatedR ClO2 OxineES Chlorine 12.5 ppm 12.5 ppmE dioxideNT Other species 4.7 ppm 72.9 ppmAT Bacteria control 7.3 x 107 7.3 x 107IO After exposure 6.4 x 107 <5N SR log -0.07 -7.86
  14. 14. Comparison of Solutions containing Equal Concentrations of ClO2 against Listeria monocytogenes Scott A Generated ClO2 Activated OxineChlorine dioxide 12.5 ppm 12.5 ppm Other species 4.7 ppm 72.9 ppmBacteria control 7.3 x 107 7.3 x 107 After exposure 6.4 x 107 <5 SR log -0.07 -7.86These results clearly show that “other species” must play a significant role in Oxine’s antimicrobial activity.
  15. 15. COMPARISON OF DISINFECTING AGENTS140012001000 Oxine Quat 800 Sodium Chlor it e Per oxy l Compl 600 Chlor ine A cid A nionic Comp 400 200 0 P S aur eus S E. coli aer uginosa cer evi si ae
  16. 16. OXINECOMPOSITION CHARACTERISTICS CHEMICAL REACTIONSChlorine Dioxide Disinfects Disinfecting ActivitySodium Chlorite Deodorizes Deodorizing ActivityOxychloro Species Sanitizes Sanitizing Activity Attacks Biofilms Attack of Biofilms Kills Microbes Antimicrobial Activity
  17. 17. QI Characteristics of ChlorineS dioxideP Chemical Formula: ClO2RES Chlorine - ClENT Dioxide - di (indicates “two”) / oxideAT (means Oxygen)I - two oxygen (O2)ON
  18. 18. QI How is Chlorine DioxideS Produced?PR * Chlorine Dioxide is explosive under pressureES * It is difficult to transport and is usually manufactured on siteE * Chlorine Dioxide today is generatedN 1. By the reaction of sodium chlorite with chlorineT 2NaClO2 + Cl2 → 2ClO2 + 2NaClATI 2. By the reaction of sodium chlorite with hydrochloric acidO 5 NaClO2 + 4HCl → 4 ClO2 + 5NaCl + 2H2ON
  19. 19. QI Can chlorine dioxide beS dissolved in water?PR Chlorine dioxide has high water solubility especially inE cold water.SE Chlorine dioxide does not hydrolyze when it enters water.N It remains a dissolved gas in solution.TA Chlorine dioxide is approximately 10 times more solubleT in water than chlorine.ION
  20. 20. Q What are theIS applications of chlorineP dioxideto clean circuit boards, It is used in the electronics industryRES In the oil industry to treat sulfides and to bleach textiles andE candles.NT Chlorine dioxide is used to bleach paper.A It produces a clearer and strong fiber than chlorine does.TIO Chlorine dioxide gas is used to sterilize medical andN laboratory equipment, surfaces, rooms, and tools.
  21. 21. Q What are theIS applications of chlorineP dioxide Chlorine dioxide is a very strong oxidizer and disinfectant.RE As a disinfectant and pesticide, it is mainly used in liquidS form.EN It effectively kills pathogenic microorganisms such as fungiT bacteria and viruses.AT It also prevents and removes biofilms.IO Chlorine dioxide can also be used against anthrax,N because It is effective against spore-forming bacteria.
  22. 22. Q What are the disinfectionIS applications of chlorineP dioxide? Drinking water TreatmentR Sewage water disinfectionES Industrial process water treatmentE Cooling tower water disinfectionN Industrial air treatmentT Mussel controlAT Foodstuffs production and treatmentI Industrial waste oxidationO Gas sterilization of medical equipmentN
  23. 23. QI Characteristics ofS sodium chloriteP Chemical Formula - NaClO2RE Sodium – Na (from the Latin Name Natrium)S Chlorite – ClO2-E Other chemical name: Chlorous acid sodium saltN (sodium salt of Chlorous acid)T NeutralizationA Acid + Base Salt + WaterTI HClO + NaOH NaClO + HOH 2 2O (H O) 2 Chlorous Sodium SodiumN hydroxide Acid chlorite
  24. 24. QIS Sodium ChloriteP * Sodium chlorite (NaClO2) is the only chlorite saltR produced commercially in significant quantities.ES It is used mainly for the generation of chlorine dioxide inE situ (on the spot)NT * Sodium chlorite (NaClO2) is used in a small number ofA water treatment plants to generate chlorine dioxide.T * This oxychlorine (oxychloro) compound (sodiumIO chlorite) is the primary precursor to chlorine dioxide in use today.N
  25. 25. QIS Sodium ChloriteP Acidified Sodium Chlorite (ASC) is aR Highly effective, broad spectrum antimicrobial.ES ASC is approved by the FDA (21 CFR 173.325)E as a ‘secondary direct food additiveN permitted in food for human consumption’T specifically as an antimicrobial intervention treatmentA for poultry carcasses, poultry carcass parts, red meatT carcasses, red meat parts and organs, seafood, andI raw agricultural commodities.ON
  26. 26. Q Characteristics of other Oxychloro speciesI CHLORITE ION CHLORINE DIOXIDES ACID (H+) OXYGEN OXYGENP [-]R 110 o 117 oE CHLORINE CHLORINES OXYGEN OXYGENENT CHLORINE DIOXIDE CHLORITE IONAT ELECTRON (e-) OXYGEN OXYGENI [-]O 117 o 110 o CHLORINE CHLORINEN OXYGEN OXYGEN
  27. 27. QIS Chlorous Acid, HClO2PR Chlorous acid is the weak acid that is intermediate in theES reaction path between sodium chlorite andE chlorine dioxide.NT Chlorous acid is thought to have high microbial activity,AT especially when combined with chlorine dioxide itself.ION
  28. 28. QIS OXINEPRESCOMPOSITION CHARACTERISTICS CHEMICAL REACTIONSEChlorine Dioxide Disinfects Disinfecting ActivityNSodium Chlorite Deodorizes Deodorizing ActivityTOxychloro Species Sanitizes Sanitizing ActivityA Attacks Biofilms Attack of BiofilmsT Kills Microbes Antimicrobial Activity ION
  29. 29. QIS Characteristics of OXINEP PHYSICAL UNACTIVATED ACTIVATED PROPERTYR STATE Liquid LiquidE COLOR Colorless Green-yellowS ODOR Very faint chlorinous odor Chlorine-like odorE pH 8.2 – 8.5 2.0 – 2.5N Boiling Point 213oF (100.5oC)T Melting Point Not determinedA Freezing Point 28.9oF (-1.72oC)T Vapor Pressure 23.7 mm Hg Vapor DensityI 0.02 kg/m3 Specific Gravity 1.03 g/ml (20oC)O Volatiles (by volumes) 97% (water)N Solubility in water Complete Evaporation rate Comparable to water
  30. 30. QI Chemical Properties ofS OXINEP Ultra high antimicrobial activityRE Disinfectant/ BacteriostatS Excellent deodorantE Uniquely effective against biofilmsNT Low corrosion potential at use concentrationA Does not chlorinate (no THM formation)TI Does not hydrolyze in waterO Resists neutralization due to organic loadN Active over a broad range of pH, 1-10
  31. 31. QI Summary ofS Antimicrobial EfficacyP BacteriaR TEST ORGANISM CONTACT TIME CONCENTRATION RESULTE Alicyclobacillus acidoterrestris 10 mins. 30 ppm 99.998% killS Bacillus cereus spores Campylobacter jejuni 5 mins. 30 sec 200 ppm 30 ppm 99.999% kill 99.9% killE Erwinia carotovora 60 sec 50 ppm 99.999% killN Escherichia coli O157:H7 Lactobacillus sp. 60 sec 60 sec 3 ppm 20 ppm 99.999% kill 99.999% killT Legionella pneumophila 60 sec 25 ppm 99.999% killA Listeria monocytogenes Mycobacterium bovis (tuberculosis) 60 sec 10 mins. 25 ppm 500 ppm 99.9999% kill 99.9999% killT Pediococcus sp. 60 sec 20 ppm 99.999% killI Proteus mirabilis 60 sec 100 ppm 99.999999% kill Pseudomonas aeruginosa 60 sec 5 ppm 99.9999% killO Salmonella typhimurium 60 sec 100 ppm 99.999% killN Staphylococcus aureus 60 sec 30 ppm 99.999% kill Streptococcus faecalis 60 sec 100 ppm 99.99999% kill Streptococcus faecium 60 sec 100 ppm 99.9999% kill
  32. 32. QI Summary ofS Antimicrobial EfficacyP FungiRE TEST ORGANISM CONTACT TIME CONCENTRATION RESULTS Aspergillus fumigatus spores 60 sec 100 ppm 99.9999% kill Aspergillus niger 60 sec 100 ppm 99.9999% killE Candida Albicans 60 sec 100 ppm 99.99999% killN Cladosporium 30 sec 500 ppm 99.999% killT Mucor sp 30 sec 500 ppm 99.999% killA Penicillium 60 sec 100 ppm 99.999% killT Penicillium roquefortii 60 sec 500 ppm 100 % killI Saccharomyces cerevisiae 60 sec 30 ppm 99.999% kill Stachybotrys chartarum 60 sec 100 ppm 99.997% killO Trichophyton mentagrophytes 5 min 500 ppm 100% killN
  33. 33. QI Summary ofS Antimicrobial EfficacyP VirusesRE TEST ORGANISM CONTACT TIME CONCENTRATION RESULTS African Swine Fever Virus 5 mins 500 ppm 100 % virucidalE Canine Parvovirus 10 mins 500 ppm 100 % virucidal Coxsackie Virus 5 mins 550 ppm 99.9% killN Foot & Mouth Disease Virus 5 mins 500 ppm 100 % virucidalT Herpes Simplex Virus Type 1 5 mins 550 ppm 99.9% killA Newcastle Disease virus Polio Virus Type 2 10 mins 5 mins 500 ppm 550 ppm 100% kill 99.9% killT PRRS virus 60 sec 312 ppm 100 % virucidalI Pseudorabies virus 10 mins 500 ppm 100 % virucidal Rhino virus 5 mins 550 ppm 99.9% killO Swine Vesicular Virus 5 mins 500 ppm 100 % virucidalN
  34. 34. QI Comparison with otherS Disinfecting AgentsP BIOCIDE ACTIVE INGREDIENT CONCENTRATION (ppm) P. aeruginosa S. aureus S. cerevisiaeR Oxine Alcide-LD Chlorine Dioxide 20,000 Sodium Chlorite 27,300 5 310 30 1300 30 640E Chlorine C-13 Sodium Hypochlorite 52,500 Sodium Hypochlorite 85,000 200 820 200 820 400 1600S Iodophor Complex-Bound Iodine 180,500 440 440 450 Wavicide-01 Glutaraldehyde 20,000 Unactivated 2,300 1,200 620E Sporocidn Glutaraldehyde activated 20,000 1,600 2,200 18,000N Hydrogen Peroxide Hydrogen Peroxide 30,000 36,000 68,000 270,000 Quat Quatemary Ammonium Compounds 580 140 74T 22,500 Octyldecyldimethylammonium Chloride 11,250 Didecyldimethylammonium ChlorideA 11,250 Diotyldimethylammonium Chloride 30,000 Alkydimethylbenzylammonium ChlorideT Acidified Quat Amphyl As Quat + Phosphoric Acid Phenolic Compounds 150 1,500 1,200 380 300 190I o-phenylphenol 105,000 o-benzyl-p-chlorophenolO Peroxy Compound I Peracetic Acid & Hydrogen Peroxide Peroxy Compound II Peracetic Acid & Hydrogen Peroxide & Acetic Acid 20 30 60 40 300 400N Acid Anionic Compound I Dodecylbenzenesulfonic Acid & Phosphoric Acid Acid Anionic Compound II Octanoic Acid, Decanoic Acid, Citric Acid & 40 80 80 150 600 200 Phosphoric Acid
  35. 35. QIS Test CriteriaPRE The criteria of the test itself was:SE to determine the lowest concentration of the variousN disinfectants which would produce a 99.999% reductionT of organism after only sixty second (60 second) contactAT time with the chemical.ION
  36. 36. QISPRES The strength or potency of the disinfectantsEN can be seen by comparing the concentrations,T expressed in parts per million (ppm)A necessary to produce the required killTI within the specified contact period.ON
  37. 37. QISPRES Those products which meet the kill criteria atEN LOWER concentrations are judged to beT MORE POTENT DISINFECTANTS,A than those that must use higher concentrationT to achieve the same result.ION
  38. 38. QI Comparison with otherS Disinfecting AgentsP BIOCIDE ACTIVE INGREDIENT CONCENTRATION (ppm) P. aeruginosa S. aureus S. cerevisiaeR Oxine Alcide-LD Chlorine Dioxide 20,000 Sodium Chlorite 27,300 5 310 30 1300 30 640E Chlorine C-13 Sodium Hypochlorite 52,500 Sodium Hypochlorite 85,000 200 820 200 820 400 1600S Iodophor Complex-Bound Iodine 180,500 440 440 450 Wavicide-01 Glutaraldehyde 20,000 Unactivated 2,300 1,200 620E Sporocidn Glutaraldehyde activated 20,000 1,600 2,200 18,000N Hydrogen Peroxide Hydrogen Peroxide 30,000 36,000 68,000 270,000 Quat Quatemary Ammonium Compounds 580 140 74T 22,500 Octyldecyldimethylammonium Chloride 11,250 Didecyldimethylammonium ChlorideA 11,250 Diotyldimethylammonium Chloride 30,000 Alkydimethylbenzylammonium ChlorideT Acidified Quat Amphyl As Quat + Phosphoric Acid Phenolic Compounds 150 1,500 1,200 380 300 190I o-phenylphenol 105,000 o-benzyl-p-chlorophenolO Peroxy Compound I Peracetic Acid & Hydrogen Peroxide Peroxy Compound II Peracetic Acid & Hydrogen Peroxide & Acetic Acid 20 30 60 40 300 400N Acid Anionic Compound I Dodecylbenzenesulfonic Acid & Phosphoric Acid Acid Anionic Compound II Octanoic Acid, Decanoic Acid, Citric Acid & 40 80 80 150 600 200 Phosphoric Acid
  39. 39. Q OXINE …ISPRES is significantlyENT SUPERIORATI to all other tested productsON
  40. 40. Comparison with other Disinfecting Agents140012001000 Oxine Quat 800 Sodium Chlor it e Per oxy l Compl 600 Chlor ine A cid A nionic Comp 400 200 0 P S aur eus S E. coli aer uginosa cer evi si ae
  41. 41. Reduction of Bacteria on Conveyor LinesQ Using Oxine as Lube AdditiveI Before and After Bacteria counts taken alongS a lubed conveyor/filler system in a large softdrink manufacturing plantPRESENTATION
  42. 42. Q By simply injecting Oxine into the lube stream atI as little as 20 ppm (unactivated),S several significant benefits result :P 1. Substantial bacterial control of the conveyor lines.R * 2-3 log reductions of counts on the conveyorsE 2. Various soils are loosened.SE 3. The natural cleaning action of the lube is enhanced.N 4. Dirt and grit slide off with the use of a pressure hose.T 5. The chains and conveyors run more smoothly withA less wear on chains and motors.T 6. The lubricity of the lube is increased.I (Result: savings in lube usage itself).O REASON: Oxine attacks the biofilms attached to theN conveyors and the underlying rails.
  43. 43. QIS FINAL BENEFITPRE Even low concentrations of Oxine in theSE lube will help DEODORIZE the areaN immediately surrounding the can orT bottle line – noticeably FRESHER andAT nearly ODOR-FREE area.ION
  44. 44. QI Study conducted by three (3) companies:S Boeing CompanyPR Douglas AircraftE United Airlines Medical DivisionSEN Nation-wide Search for the BEST DisinfectantTA to sanitize their onboard water systems andT holding tanksIO to treat their onboard potable drinking waterN
  45. 45. QI Principal Areas ofS ConcernPRES antimicrobial activityENT low corrosionATI off flavors and odors in theON water systems
  46. 46. QIS RESULTSPRE All three companies selected “stabilizedSE chlorine dioxide” (OXINE).NTA OXINE is in the maintenance manuals ofT both Boeing and Douglas Aircraft as theIO recommended compound for waterN system disinfection
  47. 47. Q COMPREHENSIVEIS STUDY OFP DISINFECTANTSR Source : Journal of Industrial MicrobiologyES volume 4 (1989) 145-154E Author : Dr. Ralph TannerNT University of OklahomaA Feature:The products evaluated covered the completeTI spectrum of sanitizers, including otherO chlorine dioxide based products.N
  48. 48. Q COMPREHENSIVEIS STUDY OFP DISINFECTANTSR RESULT:ESE OXINE is the overall most effectiveN antimicrobial product tested.TAT OXINE was dramatically more potentIO in its antimicrobial activity thanN standard sanitizers.
  49. 49. Comparison of the Activities ofQ Chlorine dioxide and Peracetic AcidI against Lactic Acid BacteriaS Condition ppm Viable cells/ml (60 sec. exposure Pediococcus LactobacillusP Control 2.5 x 106 1.6 x 106R Chlorine dioxide 20 < 2 x 100 < 2 x 100E 50 < 2 x 100 < 2 x 100S 100 < 2 x 100 < 2 x 100E Peracetic acid 100 > 105 > 105N 200 8.5 x 102 > 105T 500 < 2 x 100 7.3 x 105AT RESULTS: (for comparative purposes only)IO 1. indicate that 20ppm chlorine dioxide could reduce viableN counts of lactic acid bacteria at least 99.999% in a 60-second speed-of-kill assay
  50. 50. Comparison of the Activities ofQ Chlorine dioxide and Peracetic AcidI against Lactic Acid BacteriaS Condition ppm Viable cells/ml (60 sec. exposure Pediococcus LactobacillusP Control 2.5 x 106 1.6 x 106R Chlorine dioxide 20 < 2 x 100 < 2 x 100E 50 < 2 x 100 < 2 x 100S 100 < 2 x 100 < 2 x 100E Peracetic acid 100 > 105 > 105N 200 8.5 x 102 > 105T 500 < 2 x 100 7.3 x 105AT RESULTS: (for comparative purposes only)IO 2. suggest that about 1000 ppm of peracetic acid would beN required to achieve a similar reduction in viability, using the test.
  51. 51. SUMMARY OF FOODQI PROCESSINGS GOVERNMENTP REGISTRATIONS Product Application: Food Processing Disinfectant(Sanitizer)R Trade Name : OxineE Chemical Family : Mixture of Oxychlorine CompoundsS Active Ingredient : 2.0% Chlorine DioxideEN E.P.A. Registration No.: 9804-1TA Oxine is an E.P.A. registered disinfectant/sanitizer withT applications in food processing plants.I E.P.A. registration as a terminal sanitizing rinse for foodO contact surfaces in food processing plants such asN poultry, fish, meat, and in restaurants, dairies, bottling plants and breweries. (100ppm)
  52. 52. SUMMARY OF FOODQI PROCESSINGS GOVERNMENTP REGISTRATIONSR E.P.A. registration registration for disinfection of environmentalE surfaces on floors, walls and ceilings in food processingS plants such as poultry, fish, meat, and in restaurants,E dairies, bottling plants and breweries.(500ppm)NT E.P.A. registration as a sanitizing rinse of uncut and unpeeled fruits and vegetables at 5ppm followed by a potable waterA rinse.TI E.P.A. registration as a bacteriostat in ice making plants andO machinery. (20 ppm)N
  53. 53. SUMMARY OF FOODQI PROCESSINGS GOVERNMENTP REGISTRATIONSR F.D.A. approval as a terminal sanitizing rinse, not requiring aE water rinse, on all food contact surfaces. (100-200 ppm)S 21 CFR 178.1010E F.D.A. Letter of no objection for the use of stabilized chlorineN dioxide at 20 ppm for treating ice used for icing fish inT the roundAT F.D.A. approval as an antimicrobial agent on raw agricultural commodities at 500-1200 ppm acidified sodium chloriteI followed by thermal processing or a potable water rinse.O 21 CFR 173.325N
  54. 54. SUMMARY OF FOODQI PROCESSINGS GOVERNMENTP REGISTRATIONSR F.D.A. approval as a sanitizing wash for uncut and unpeeledE fruits and vegetables at 3 ppm free chlorine dioxide followed by the thermal processing or a potable waterS rinse. 21 CFR 173.300E F.D.A. approval as an antimicrobial agent on raw agriculturalN commodity in preparing, packing or holding. Applied asT a dip or spray at 500- 1200 ppm acidified sodiumA chlorite followed by a thermal process or a potableT water rinse. 21 CFR 173.325I F.D.A. approval as an antimicrobial agent in water used inO poultry processing at 2 ppm chlorine dioxide. 21 CFR.N 173.300
  55. 55. SUMMARY OF FOODQI PROCESSINGS GOVERNMENTP REGISTRATIONSR F.D.A. approval as an antimicrobial agent in poultryE processing water as a component of:S - Carcass spray or dip at 500-1200 ppm acidified sodiumE chlorite. 21 CFR 173.325N -Prechiller/chiller tank at 50-150 ppm acidified sodiumT chlorite. 21 CFR 173.325AT F.D.A. approval as an antimicrobial agent in water or ice (40I – 50 ppm acidified sodium chlorite) used to wash, rinse,O thaw, transport, or store seafood. 21 CFR 173.325N
  56. 56. SUMMARY OF FOODQI PROCESSINGS GOVERNMENTP REGISTRATIONSR F.D.A. approval as an antimicrobial agent in the processingE of red meat as a component of a carcass spray at 500-S 1200 ppm acidified sodium chlorite. 21 CFR 173.325EN F.D.A. approval as an antimicrobial agent on processed,T comminuted or formed meat food products (unlessA precluded by standards of identity….). Applied as a dipT or spray at 500-1200 ppm acidified sodium chlorite priorI to packing 21 CFR 173.325ON
  57. 57. SUMMARY OF FOODQI PROCESSINGS GOVERNMENTP REGISTRATIONS U.S.D.A., D-2 approval as a terminal sanitizing rinse, not requiringR a potable water rinse, on all food contact surfaces found in food processing plants. (Use according to Label Instructions)E U.S.D.A, P-1 approval for bacterial and mold control in federallyS inspected meat and poultry processing plants forE environmental surfaces. (Use According to LabelN Instructions.)T U.S.D.A., 3-D approval for washing fruits and vegetables thatA are used as ingredients of meat, poultry and rabbit products followed by a potable water rinse. (UseT According to Label Instructions.)I U.S.D.A., G-5 approval for cooling and retort water treatmentO (According to Label Instructions.)N
  58. 58. QI OXINE’s – Profile ofS ExcellencePRE A Focus on Chlorine Dioxide: The Ideal BiocideS G. D. Simpson, R. F. Miller, G. D. Laxton, andE W. R. ClementsN Unichem International Inc.T 16800 Imperial Valley Drive, Suite 130A Houston, Texas 77060TI Meitz, "Environmental Concerns and Biocides,"O Paper No. 306, Corrosion 91, March 11-15, 1991.N
  59. 59. QIS PERFORMANCEP It must exhibit rapid kill of target organisms, with a highR LC50 toward non-target organisms.ES It must be able to keep systems clean of biofilm; ideally itE should be able to clean up already fouled systems.N It should not be consumed by materials commonlyT encountered in cooling systems, e.g., hydrocarbons,A wood, plastic, or other treatment chemicals.TI Finally, it must be effective over a wide range of operatingO conditions.N
  60. 60. QIS ENVIRONMENTPRES Side or by-product reactions should be minimized andE reaction products should be environmentally friendly;NT Neither it, its by-products, nor its reaction products shouldA persist in the environment.TION
  61. 61. QIS SAFETYPRES It must be safe and easy to handle.ENTATION
  62. 62. QIS ECONOMICSPRES It must be affordable.ENTATION
  63. 63. COMPARISON OF OXIDIZINGQI BIOCIDESS IN LIGHT OF THE CRITERIA OF AN IDEAL BIOCIDEPR HOCl HOBr ClO2 O3E PERFORMANCES High pH C B A AE Kinetics B B A AN Selectivity C B A DT Biofilm B B A CA System Contamination C C A DT Bacterial Recovery B B A CI ENVIRONMENTALO THM C C B AN TOX C C B A
  64. 64. COMPARISON OF OXIDIZINGQ BIOCIDESIS IN LIGHT OF THE CRITERIA OF AN IDEAL BIOCIDEPR HOCl HOBr ClO2 O3E ENVIRONMENTALS ToxicityE of primary oxidant B A A CN of oxidation by-products B B C AT of oxidation reaction products B C A DA residual life (short life best) C B C AT SAFETYI Easy to Use B B C BO Safe to Handle B B C BN
  65. 65. COMPARISON OF OXIDIZINGQ BIOCIDESIS IN LIGHT OF THE CRITERIA OF AN IDEAL BIOCIDEPRE HOCl HOBr ClO2 O3S ECONOMICSE Clean System A B B CN Contaminated System C C A CTA Cumulative GPA 2.6 2.8 3.3 2.7TION
  66. 66. QI OXINE’s profile of excellenceS is no elusion.PRE Numerous independent processing facilities,S government research laboratories, privateE laboratories and universities have selectedN OXINE as theTATIO “BEST OF THEN BEST”
  67. 67. QISPRE Presentation EndsSENTAT THANK YOUION

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