Numerous heavy metals which are toxic the most toxic are lead,mercury,cadmium,arsenic,aluminium,antimony,tin,nickel,thallium as well as ones that are essential but dangerous in excess namely Iron and copper which we will discuss later
When they enter the bodythey go thro a chemical biological processcalled oxidation and form free radicals.It is now indisputed that free radical damagecontributes significantly to the degeneratuve process of ageing.Act akin to sparks in a fire damagingcells and resulting in the diseases so often reffered as the ageing diseases.when cells are damaged they no longer function properly resulting in damage to the tissues andfinally to the organs of the body.Symptoms may not appearfor yearsas the body stores these toxins in various tissues.Bones and fatty deposits.Symptoms of chronic metal toxicity are therefore insidiousand non specifucand include fatigue,malaise and increased susceptility to infections.Excessive free radical activity cannot be avoided in todays environment.When this dagenerative process happens to the cells in your body you can easily see why you do not have the energy you should.You don’t repair as well as u used to,u get older more quickly and u wear out much faster than you want.When this process affects your blood vessels u develop circulatory problems leading to poor skin texture etc etc
Antioxidants in diet and producedin the body during the course of normal metabolism protect us by preventing these heavy metals from becoming oxidated and behaving as free radicals. Exaplles of antioxidants are etc etc.So a diet rich in these is advised.
Diet supplementation skinn release etc are all useful methods for dealing with heavy metals.Over time these natural processesare unable to defend us resulting in the diseases already mentioned
Recent advances in autism treatment
Recent Advances in the
treatment of Autistic
By the end of 7 months
Smile back at another person
Respond to sound with sounds
Enjoy social play
• No big smiles or other warm, joyful
expressions by six months or thereafter
• No back-and-forth sharing of sounds,
smiles, or other facial expressions by nine
months or thereafter
By the end of 12 months
Use simple gestures
Imitate actions in their play
Respond when told “no”
• No back-and-forth gestures, such as
pointing, showing, reaching, or waving bye
• Not answering to one’s name when called
• No babbling – mama, dada, baba
By the end of 18 months
Do simple pretend play
Point to interesting objects
Use several single words unprompted
• No single words by 18 months
• No simple pretend play
By the end of 2 years
Use 2- to 4-word phrases
Follow simple instructions
Become more interested in other children
Point to object or picture when named
• No two-word meaningful phrases (without
imitating or repeating)
• Lack of interest in other children
Red Flag: Any loss of speech or
babbling or social skills
Regression at any age is cause for
The emergence of a
new autism model
• Genetically determined
• Brain based
• Treatable but not curable
Is autism a BRAIN
• Environmentally triggered
• Genetically influenced
• Both brain and body
• Metabolic abnormalities play big
• Treatable and recovery possible
OR is it
A DISORDER THAT
AFFECTS THE BRAIN?
AUTISM is A Medical condition .
It is not a mental Disorder
As such it is preventable
Minimize core features and associated deficits
Maximize functional independence and QOL
Alleviate family stress
Sensory, fine motor, gross motor
Behaviorally Based treatments
Core and associated symptoms
Medical or biologic treatments
Support family in home and community
ABA (Applied Behavioral Analysis)
General behavioral teaching approach involves reinforcement
and consequences to shape behavior
All of our parents used it!
Involves the A, B, C’s
Not airway, breathing circulation
Behaviorally based/ intensive structured teaching
E.g., Verbal Behavior
Aided augmentative/ alternative system(s)
Decrease non-communicative language
appropriate use of language in social situations
Social skills training
Adjunct to educational,
developmental & behavioral
So far no evidence of impact
on core symptoms
Evidence supporting is
Toolkit – handouts for MD &
Treat target symptoms
Manipulative and Bodybased
Transcranial & magnetic
Most commonly used
~ 50% - biologically based
30% - mind body
25% - manipulation/ body
** Most use > 1 modality
One of most commonly used CAM treatments
Exogenous opiate-like peptides = false neurotransmitters
Evidence – most non-blinded; few RCT emerging, no differences
elimination of ALL dairy products (not “GFCF except for ice
cream…”) & elimination of barley, rye, oats & wheat products
Inherently deficient in calcium, vitamin D
B vits, Iodine, others may be lower in substitute products
Weight typically adequate, monitor Fe status
Another approach to therapy
Dealing with the yeast overgrowth.
Dealing with the leaky gut.
Heavy metals and their effects.
with before dealing with
the heavy metal issue
There are 3 main issues common to all autistic Children
1. Yeast Overgrowth
2. Leaky gut
3. Heavy Metal Accumulation
Yeast overgrowth leads to poor absorption of
necessary vitamins, minerals & esssential nutrients.
It is normal to have a small amount of yeast in the GI
tract. Autistic children however have abnormal
amounts, usually leading to poor absorption of
essential nutrients and the leakage of toxic substances
into the bloodstream which should not be absorbed.
How do we treat the Yeast
overgrowth & Leaky gut
Nutrition/Antioxidants in food and metabolised in
Vitamins A, B Complex, C, E, B12 , B6, Folic Acid, Niacin
Essential Fatty Acids These are extremely important.
They are a most powerful anti-inflammatory agent.
Trace elements – Magnesium, Selenium, Chromium, Zinc
Reduced L glutathione,N Acetyl cysteine, Alpha-Lipoic
and where do they come
Lead – petrol, paint, batteries, certain water mains
Mercury – fillings in teeth, fish, paint, numerous
appliances such as mercury thermometers, nasal
sprays and eye drops, certain vaccines.
Cadmium – Cigarettes, tyres, metal platings
Arsenic – Pesticides, chicken feeds, rice, treated
and where do they come
Aluminum – Cooking wares, aluminum
foil, antacids, certain vaccines, canned
Antimony – Carpets, flame retardant
Heavy Metals – how are we protected
against these free radicals
Diet /nutrition– “let food be your medicine
and let medicine be your food”- Hippocrates
Good kidney eliminations
Good bowel eliminations
What are the effects of these toxic metals
They are oxidised to form free radicals resulting in
the destruction of cells,
They affect organs ,interfere with enzyme systems,
inhibit prostaglandin formation. Weaken the immune
system, inhibit the proper functioning of cells,
contribute to gastrointestinal problems, and are
What Chelation agents are there
EDTA-Ethylene diamine tetra acetic acid
TTFD Transdermal Allithiamine
How are they used
EDTA is effective only intravenously.It is used in
adults in the form of MG EDTA for Heart
Disease,Circulatory disorders,neurological disorders,
and the chronic degenerative diseases.
DMSA (dimercocaptosuccinic acid)
TTFD/allathiamine (active form of B1)
EDTA and its safety
Given according to ACAM protocol millions of
chelations in past 30 years no recorded death.
Doctors licensed in western Canada since 1997 No
NIH conducting $30 million clinical trial on 2,300
patients no serious adrs
NIH 800,000 I.V EDTA chelations in U.S. alone no
Not suitable for ASD children 3 hour i.v. inneffective
in chelating mercury
Powerful chelator of all other toxic heavy metals
Metal Dertoxification in Auistic children
DMSA is the most widely used , convenient, safe , and
given orally. It is a good chelator of Mercury, Lead
Dmps May be given intravenously. A good chelator of
mercury,often used as a provovative agent, usually
given in oral form
Chelating With the oral chelators
DMSA is given orally according to the Dan protocol 10mg/kg body
weight/3times daily for three days on and 11 days off.
Repeat Full Blood Count and Blood chemistry tests at 3 to 4 month
Mobilization and excretion of the heavy metals produces a shift in the
equilibrium between the various compartments of the body. This
exerts an almost magnetic effect on metals in depots which are not
directly accessible to the chelating agent. The body attempts to
restore an equilibrium between the depots again. The heavy metals
will then migrate partially into compartmenst where it is accessible to
the chelating agent.
Advantages of DMSA over DMPS
DMSA more widley used therefore greater experience with its use and
well established safety profile.
Well established in the DAN protocol.
No well established oral DMPS protocol.
DMPS used more in acute poisoning with Lead, Mercury, Arsenic etc.
DMSA is more effective in removing Mercury from the brain,
particularly when combined with Alpha Lipoic Acid.
Disadvantages of DMSA oral
DMSA may feed into the yeast/leaky gut/Gastrointestinal problems.
DMPS is not as severe on the gastrointestinal problems
DMPS used by some physiciansina once weekly dosage of 100 mg per
Is over 50 % absorbed
Metylathion is the process by which a single Carbon
atom is transferred from a Methyl donor to another
molecule.This process is essential to life itself.
Dr. Richard Deth of Boston believes that Thiomersail
interferes with the Metylathion process in converting
Vitamin B12 to Metylcobalamin.
In many cases Autsim can be treated effectively by
the Administration of Metyl B12 to augment the
Biosynthesis of Active Methylcobalamin
The low levels of Glutathione in autistic children will
adversely affect their ability to detoxify and protect
against heavy metals such as Thiomersal.
As impaired Methylation is important in Autism, the
administration of Methylcobalamin should bring
about an improvement.
Dr. James Neubrander has found significant
improvement with injections of Methylcobalamin by
giving the Methylcobalamin every 3 days.
Improvements were noted in Attention, language
ability and social skills.
How is Methylcobalamin given?
Dosage recommendation is 65 micrograms per
Kilogram Bodyweight every 3 days.
This means that as much as 1250 micrograms is
present in 0.05ml
The needle 30 gauge 3/10 Ultrafine BD insulin. It may
be given by the parent while the child is sleeping.
It is inserted into the buttock at a 30 – 45 degree
angle just under the skin.
Should these effects occur one does not necessarily
stop the treatment.
If Adverse effects are tolerable the treatment should
Concentrated Metylcobalamin by Injection
Metylcobalamin is the active Co-enzyme element of
B12 is present in the brain and central nervous system
as Metylcobalamin & is Non toxic.
It is known that Metylcobalamin metabolism is
impaired in the Autistic child.
Much information on this is available for Dr.
Heavy Metal Toxicity
Wheat (gluten) and milk (casein) free diet
Candida diet (sugar, arabinose, tartaric acid)
Hypoallergic diet to prevent autoimmunity
Anti-inflammatory diet to control inflammation
Supplements including EFA, probiotics, glutamine,
Asses presence of heavy metals
Investigate heavy metal exposure
Undergo chelation therapy for removal of heavy
Evaluate levels of Glutamate/GABA,
serotonin and dopamine
Why does food matter?
Opium, gluten and milk in Autism
Breakdown of gluten and casein by secretions of the pancreas and the
intestines create peptides (small proteins) that are similar in structure
to endorphins (the body’s natural pain killer). These peptides have
Normally, these peptides are degraded and excreted with little effect.
In autistic patients, these peptides can lead to reduced brain electrical
activity and thus altered behavioural changes.
This activity is improved by naltrexone administration (an opioid
antagonist) therefore proving opioid action.
Much anecdotal evidence exists of significant improvement in autistic
symptoms when milk and wheat are eliminated from the diet.
A study using 15 autistic children correlated significantly increased urine
exorphin level with autistic spectrum patients. Elimination of milk
and gluten from the diet resulted in improvement of social, cognitive
and communications sills, commensurate with reduction of urinary
exorphin level. Knivsberg et al, 1990
Atypical antipsychotic, Abilify
(Aripiprazole) oral formulation
was approved November 24,
2009 by the FDA for the
treatment of irritability
associated with ASD in children
aged 6-17 years.
Data based on two 8 week,
multicenter studies evaluating
its efficacy for improving mean
scores on the Caregiver-rated
Irritability subscale of the
Aberrant Behavior Checklist
Multi dimensional approach
It should be remembered that improving Methylation
capacity is only one component of the multi
dimensional approach in the treatment of Autism.
Gluten Casein free diet