Overview of viruses and their properties

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A table summarising the content in virology of the pathology course of 2nd year medical school in Cambridge.

A table summarising the content in virology of the pathology course of 2nd year medical school in Cambridge.

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  • 1. Genome Coat Additional Genome Example Resulting Replica- Approx. Fragmen- Capsid Capsid proteins Life cycle infect- Other Type Family Envelope species disease tion size tation shape size present ious? tumours in polyomavirus papova- rodents viridae 5-8kbp: tumours in - icosahedral 50nm - SV40 - (papilloma- small rodents * stimulate polyoma- vacuolating) warts, cell into cell papillomavirus carcinoma cycle! adeno- 35kbp: * herpes - icosahedral 80nm - adenovirus resp disease - viridae medium viruses 1. uncoating herpes simplex, cold sores, incease the 2. DNA to nuc type 1 + 2 genital lesions prod of 3. replication DNA chicken pox, nucleus dNTPS varicella-zoster 4. RNA to cp infectious shingles * can cause 5. prot.to nuc glandular latent 6. Assembly epstein-barr fever, burkitt infection herpes- 150kbp: with DNA in nuc - icosahedral 120nm - lymphoma - * consist of dsDNA viridae large cytomegalic extrachomos (lytic!) cytomegalo- inclusion omal circular virus disease in DNA neonates human kaposis herpesvirus 8 sarcoma viriola smallpox virion transcriptase: * produce 1. uncoating DNA-dependent EGF that 2. Make mRNA 200kbp: 200- RNA DNA not cyto- stimulates pox-viridae - complex + vaccine against 3. translate large 300nm vaccina polymerase, infectious plasm neighbour- smallpox 4. Assemble capping and ing cells into and release polyadenylating cell cycle! enzymes dsDNA hepaDNA- acute andwith RNA viridae 3kbp: chronic * DNA->RNA- - icosahedral 20nm + hepatitis B - ? nucleusintermedi reversi- small hepatitis, liver >cDNA ate viruses cancer childhood rash * most 5kb: human ssDNA parvo-virus - icosahedral 20nm - (erythema - ? nucleus strands infect small parvovirus infectiosum) animals C.Riedinger Overview of Viruses
  • 2. Genome Coat Additional Genome Example Resulting Replica- Approx. Fragmen- Capsid Capsid proteins Life cycle infect- OtherType Family Envelope species disease tion size tation shape size present ious? papova- reo-viridae 20kbp: 10-11 human acute infantile viriondsRNA viridae (resp. enteric 5-8kbp: icosahedral 70nm - orphan virus) medium fragments - icosahedral 50nm - rotavirus gastro-enteritis transcriptase - (papilloma- small * stimulate polyoma- vacuolating) poliovirus poliomyelitis cell into cell picoRNA- cycle! hepatitis A acute hepatitis * negative viridae 7kb: - * herpes is - icosahedral 25nm rhinovirus common cold strand (small RNA virus) small lytic viruses to foot and mouth foot and mouth 1. uncoating made disease disease incease the generate 2. DNA to nuc winter prodmore of 8kb: - 3. replication DNA calici-viridae - icosahedral 35nm norovirus vomiting nucleus dNTPS 4. RNA to cp infectious cytoplas template (calyx/goblet) small lytic * can non- disease * cause RNA-dependent 5. prot.to nuc m,as +ve latent enveloped german RNA polymerase 6. Assembly RNA infection rubella 1. uncoating with DNA in nuc RNA-viruses measles direct * consist ofdsDNA 2. Translation are lytic +ve RNA template, extrachomos(lytic!) toga- acute and into RNA pol * mRNA isssRNA 11kb: infectious can omal circular viridae, flavi- - icosahedral 60nm + hepatitis C chronic and capsid polycistronic medium replicate DNA viridae hepatitis proteins * picoRNA in yellow fever jungle yellow 3. Assembly viruses enucleate (ZOONOTIC!) fever and release stable d cells west nile encephalitis outside the host * an get severe acute hepA from corona- 30kb: RNA-dependent - helical 140nm + SARS respiratory food and viridae medium RNA polymerase syndrome water C.Riedinger Overview of Viruses
  • 3. Genome Coat Additional Genome Example Resulting Replica- Approx. Fragmen- Capsid Capsid proteins Life cycle infect- Other Type Family Envelope species disease tion size tation shape size present ious? * HA envelope papova- ortho- protein binds 12kb: virion viridae myxoviridae 5-8kbp: 8 fragments helical 80nm + influenza influenza sialic acid medium - icosahedral 50nm - - transcriptase (papilloma- (mxyo - mucus) small * enters by * stimulate polyoma- vacuolating) endocytosis! cell into cell cycle! * herpes helical (but * influenza viruses measles measles 1. uncoating pleiomorphi virus unique: incease the -ve para- 15kb: virion 2. DNA to nuc * RNA not cytoplas - c, i.e. 150m + 1. Make mRNA prod RNA of ssRNA myxoviridae medium transcriptase 3. replication infectous DNA m different from -ve strand processing in nucleus dNTPS 4. RNA to cp infectious shapes) mumps mumps 2. translation nucleus * can cause 5. prot.to nuc respiratory 3. Assembly latent bronchitis 6. Assembly synycytial virus and release infection with DNA in nuc * consist of dsDNA helical rhabdo- rabies extrachomos (lytic!) 10kb: capsid, 200x80n virion viridae - + (ZOONOTIC) rabies omal circular small bullet- m transcriptase (rhabdo = rod) DNA shaped * reverse transcription! Envelope * input RNA protein converted to GP120 + dsDNA +ve Acquired CD4/coR on retro- (provirus) to be ssRNA human immuno- T-cells/macro viridae 8kb: virion integrated intowith DNA - ? 100nm + immunodeficie deficiency * envelope reversi- small transcriptase hostintermedi ncy HIV syndrome protein viruses chromosome ate AIDS enters by * packaging in FUSION! cytoplasm as * can spread RNA packed as cell- associated virus * can be dsDNA hepaDNA- acute and latent ifwith RNA viridae 3kbp: chronic - icosahedral 20nm + hepatitis B - proviral DNAintermedi reversi- small hepatitis, liver not ate viruses cancer transcribedunderlined: these viruses cause persisten infection that can lead to neoplasia C.Riedinger Overview of Viruses