A 25 years old boy having oropharyngeal infection for one week. He is taking penicillin’s. Which statement about the bio disposition of penicillin’s and cephlosporins is not accurate?
Oral bioavailability is affected by liability in gastric acid
Most third generation cephlosporins cross the blood brain barrier
Nafcillin and ceftriaxone are eliminated by mainly via biliary secreation
Procaine penicillin G is used via intra muscular injection
Renal tubular reabsorption of beta- Lactams is inhibited by probenecid
A young female having a urinary tract infection on urine C/S there is E.Coli sensitive to cephalosporin. The primary mechanism of antibacterial action of cephlosporins involves
Production of Beta- Lactamases
Inhibition of Cell membrane synthesis
Inhibition of Reaction involving transpeptidation
Decreasing Synthesis of N- acetyl muramic acid
Preventing Trans glycosylation
A 40years old man having an infection involving enterobacter spp. Which of the drug is drug of choice now a days?
An elderly male has a fever believed to be due to an infection. He has skin lesions scrapings of which reveal the presence of large number of gram positive cocci. The drug to use for the treatment of this patient is?
A 40 years old female treated for Leukemia two month back. She is admitted to the hospital with malaise, chills and high fever. Gram stain of blood reveals the presence of gram negative bacilli. The initial diagnosis is bacteremia and the parenteral antibiotics are indicated. The records of the patients reveal that she had a severe urticarial rash, hypotension and respiratory difficulty after oral penicillin V about 6 month ago. The drug regimen for empiric treatment is?
Ampicillin plus sulbactam
Imipenem plus cilastatio
Ticarcillin plus clavulanic
A female patient needs antibiotic treatment prophylaxis before going for a tooth extraction. Her medical history includes a severe anaphylactic reaction to penicillin G during the past year. The best approach would be treatment with:
Cefazolin plus gentamycin
A man is on vancomycin for one week. Which statement about vancomycin is accurate
It is bacteriostatic
It is binds to PBPs
It is not susceptible to penicillinase
It has good oral bioavailability
Staphylococcal enterocolitis occurs commonly with its use
A 10 years old child is taking Ampicillin for upper respiratory tract infection. Which of the following statements about ampicillin is not accurate?
Antibacterial activity is Enhanced by sulbactam
Causes maculopapular rashes
Drug of choice for L monocytogenes infection
Eradicates most strains of MRSA
May cause pseudomembranous colitis
A 25 years old female has primary syphilis. She has a history of penicillin hypersensitivity, so tetracycline will be used to treat the infection. Which statement about the proposed drug treatment of this patient is accurate?
Antacids will not affect absorption of the drug
Azithromycin would not be effective in treatment of this patient
For full effectiveness tetracycline must be taken for 15 days
She should eat plenty of yogurt to prevent vaginal candidiasis
Tetracycline is potent inhibitor of hepatic drug metabolizing enzymes
A patient having culture positive enterococcal bacteremia. Who has failed to respond to vancomycin because of resistance, the treatment most likely to be effective is?
A 28 years old man having a degenerative joint disease is to undergo insertion of hip prosthesis. To avoid complication due to postoperative infection, the surgeon will pretreat this patient with an antibiotic. This hospital has a significant problem with methicillin resistant staphylococcus aureus. Which of the following antibiotics should the surgeon select?
A 28 years old male returns home from a holiday in the far days east and complains of three days of dysuria and a purulent urethral discharge. You diagnose this to gonorrhea. Which of the following is appropriate treatment?
Ceftriaxone intra muscular
Penicillin G intra muscular
Gentamycin intra muscular
Piperacillin intra Venus
Vancomycin intra Venus
19 years old beautiful, fair skinned girl visits her dermatologist at a local clinic because of a rash that appeared after she spent the sunny weekend kite flying with her friends. She was put on a drug for two months to prevent acne flare ups. The drug responsible for her recent concerns may be:
40 years old bus driver presents to the clinic with severe headache and tinnitus. Upon investigations he is found to have an increased intracranial pressure but the CSF composition is normal. No hydrocephalus, mass, or structural or vascular lesion. No obvious cause is identified except a history of antibiotic therapy. Which of the following drug may be responsible for this condition?
Drug of first choice for MRSA is:
Medical students are discussing the clinical uses of antimicrobials when they come across a beta lactam antibiotic named methacillin. After considerable arguments they approach their instructor. The instructor wouyld tell:
It is used to treat gram positive infection
It is used to treat Methacillin Sensitive Staphylococcus Aureus (MSSA)
It is used to treat Vancomycin Resistant Staphylococcus Aureus (VRSA)
It is used to treat Vancomycin Resistant Enterococci (VRE)
It is not used therapeutically
After taking a macrolide the girl develops severe diarrhea and colitis, which of the following drugs may be of use in antimicrobial associated diarrhea?
49 years school teacher has been regularly taking warfarin, an anti-coagulant for his long standing coagulation disorder. He develops upper respiratory tract infection and goes to a quack who prescribes an antibacterial without bothering about his drug history. After a couple of doses he develops frank bleeding from gums. Which antimicrobial may have been wrongly prescribed?
Drug of choice for treatment of mycobacterium avium complex in AIDS patient is:
c) Penicillin G
Which of the following groups of antibiotics demonstrates a bacteriostatic effect?
c) Penicillin G
Mr. Smith is a patient of chronic renal failure and has regular dialysis. The tetracycline antibiotic that does not require dose reduction to treat his skin lesions is:
A 61 years old male smoker presents with headache, weakness, fatigue and decreased urinary output, he has hyponateremia and urine osmolality is markedly increased. He might be suffering from a condition that may be treated with:
Vancomycin resistant staphylococci may be given a trail of:
A thirg generation cephalosporin
The term MIC refers to:
Minimum Inhibitory Concentration of an anti microbial in blood
Minimum Inhibitory Concentration of an anti microbial in a confined medium
Minimum Inhibitory Concentration of an anti microbial in a diseased tissue or organ
Minimum Inhibitory Concentration of an anti microbial against bacterial in a population
Minimum concentration required to kill the bacteria in the body
After an antimicrobial overdosage little Johnny developed irregular and rapid respiration, abdominal distention, periods of cyanosis, and passage of loose, green stools occur. He was severely ill by the end of the first day. Over the next 24 hours, he turned an ashen-gray color and became flaccid and hypothermic. The most likely antimicrobial he has taken is: