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MPH 605Environmental HealthLecture #3<br />Dr. Sylvia Hood Washington<br /> Monday, April 12, 2010<br />
TOPIC  Risk Assessment<br />Risk Assessment<br />Environmental Health Risk Assessment Process<br />Risk Management<br />Do...
Risk Assessment<br /><ul><li>Risk assessment is the process of identifying and evaluating adverse events that could occur ...
As per Kaplan, risk assessment is trying to answer three questions:</li></ul>What can happen?<br />How likely is it to hap...
4<br />
The framework for environmental health risk assessment was created in 1983 in a National Research Council Report, Risk Ass...
1. Hazard Identification<br />This is the process of identifying and selecting the environmental agent and health effect f...
2. Dose-Response Assessment<br />This element of the risk assessment process attempts to describe the quantitative relatio...
Dose-Response Modeling<br /><ul><li>Dose-response   determine interpolations between tested doses.  Model selection should...
The multistage model postulates that a sequence of k critical sub-cellular events (mutation, changes in gene expression or...
Mechanistic, biologically based or biologically motivated dose-response models attempt to model the dose to disease proces...
9<br />Dose-Response Modeling<br />Monotonic dose-response models can be expressed using a simple concept that is known as...
10<br />
3.Exposure Assessment:<br />This includes the estimation or measurement of the:<br /> magnitude<br /> duration<br />  timi...
4.Risk Characterization:<br />Finally, risk characterization consists of combining the information from the other steps in...
Risk Management<br />De Minimus Risk:  This is the idea that some risks are so small that that they are acceptable or insi...
14<br />
Uncertainty Analysis<br />There are two approaches to such analysis:  internal and probabilistic.<br />Internal:  This app...
16<br />
Criticism<br />Controversy often arises over:<br /><ul><li>the use of conservative default assumptions in exposure assessm...
the inadequacy of data and models for assessing affects
… and the wisdom for basing policy decisions on highly uncertain risk estimates.</li></ul>It is challenged because of the ...
Exposure Assessment<br /> Exposure Assessment, Industrial Hygiene and Environmental Management<br />Discussion Topics<br /...
Industrial Hygiene vs. Exposure Assessment<br />Industrial hygiene and exposure assessment share a common task:  quantifyi...
Anticipation<br />Anticipation can be thought of as the pre-preliminary assessment made prior to going into the field.  Pr...
Recognition<br />The initial recognition of the hazards is completed through a visual inspection (site visit or walk-throu...
Evaluation<br />In small facilities or where required, a census sample is taken and then all potentially expose individual...
Control<br />The hygienist can take several approaches to changing the workplace through substitution, isolation and venti...
Time course is an important factor of exposure because some contaminants are relatively readily metabolized at low levels ...
25<br />Routes and Pathways<br />There are three principal routes of exposure for contaminants to enter the body: <br />in...
Researchers use indirect exposure assessment methods that forgo direct measurements of the exposures of interest or that u...
27<br />
28<br />Measuring Environmental Exposure<br />Constant measuring occurs to allow for detailed exposure information which c...
29<br />Measuring Personal Exposures<br />  This involves outfitting an individual with monitoring equipment that measures...
Ingestion<br />One approach is to collect duplicate portions of food that is eaten and complete an analysis or duplicate d...
31<br />Measuring Biomarkers:<br />In order to measure the exposure levels in an individual is through the use of biologic...
32<br /><ul><li>In the US, occupational injury death per year is between 5,000 to 6,000 however, occupational illness lead...
Globally, the data gets worse as more hazards are introduced in poorer nations.
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Week 3 Occupational Hazards &amp; Risk Spring 2010!!

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  • Based on the red book, risk assessment and risk management activities should be separated to ensure that the best science is used. Risk managers are faced with the challenge of judging the significance of risks, comparing risks and costs for different risk management strategies, discussing them with stakeholders and ultimately making the appropriate decision or recommendation.
  • Simply stated, uncertainty analysis consists of a qualitative description of the sources of uncertainty in risk assessment and their potential impacts. Uncertainty analysis is often quantitative and provides a range or distribution of reasonable risk estimate.
  • Criticism of risk assessment is commonplace due to the fact that risk assessments are typically based on both empirical evidence and hypotheses or on science and judgment.
  • Once the potential hazards have been anticipated, the next step is recognition of the hazards.
  • The evaluation component focuses on quantifying the degree of exposure. The hygienist needs to determine which workers’ exposure will be studied. Once the population is selected, the type of population sample to be taken needs to be determined. In larger facilities, this type of monitoring can be quite expensive and so a statistically representative sample is monitored.
  • Control corresponds to the public health practice of primary prevention.
  • Industrial hygiene tends to focus on workplace exposures which only affect a subset of the population. Exposure assessment focuses on quantifying exposures that affect individuals as they go about their daily activities.Key concepts of exposure assessment are concentration, exposure and dose.
  • UV DETECTOR
  • Different jobs will pose different threats such as healthcare workers’ exposure to infectious disease or an office employee’s level of stress.There are also many jobs and employees whose health and safety data is lacking therefore the workplace threats or risks are undocumented and will be untreated and unregulated.
  • Different jobs will pose different threats such as healthcare workers’ exposure to infectious disease or an office employee’s level of stress.There are also many jobs and employees whose health and safety data is lacking therefore the workplace threats or risks are undocumented and will be untreated and unregulated.
  • Occupational risks have always been of concern, but reproductive issues, have just recently been identified. Some occupational risks are minor, while others are fatal such as cancers, injuries of miners or construction workers. Many of the occupational risks can be addressed thru primary prevention but sometimes the prevention can be a problem. For example, wearing earplugs to avoid machinery noise blocks “welcomed” noise such as alarms.
  • Transcript of "Week 3 Occupational Hazards &amp; Risk Spring 2010!!"

    1. 1. MPH 605Environmental HealthLecture #3<br />Dr. Sylvia Hood Washington<br /> Monday, April 12, 2010<br />
    2. 2. TOPIC Risk Assessment<br />Risk Assessment<br />Environmental Health Risk Assessment Process<br />Risk Management<br />Dose-Response Modeling<br />Uncertainty Analysis<br />Criticism<br />2<br />
    3. 3. Risk Assessment<br /><ul><li>Risk assessment is the process of identifying and evaluating adverse events that could occur in defined scenarios.
    4. 4. As per Kaplan, risk assessment is trying to answer three questions:</li></ul>What can happen?<br />How likely is it to happen?<br />What are the consequences if it does happen?<br />Environmentally, risk assessors focus on health impacts that may occur from exposure to particular agents, from …<br />the workplace,<br /> living environment or<br /> from visiting a particular environment<br />3<br />
    5. 5. 4<br />
    6. 6. The framework for environmental health risk assessment was created in 1983 in a National Research Council Report, Risk Assessment in the Federal Government, which is commonly referred to as the red book. It divides risk assessment into four elements:<br />hazard identification<br /> dose-response assessment<br />exposure assessment and<br /> risk characterization. <br />5<br />Environmental Health Risk Assessment Process<br />
    7. 7. 1. Hazard Identification<br />This is the process of identifying and selecting the environmental agent and health effect for assessment. <br />The process includes causal inference for particular health outcomes that is based on toxicological and epidemiological evidence for causation. <br />The scope of inquiry can be one agent and one health affect or the scope can be much broader.<br />6<br />
    8. 8. 2. Dose-Response Assessment<br />This element of the risk assessment process attempts to describe the quantitative relationship between exposure and disease. <br />A mathematical model is developed (or selected) and is used to predict the level of toxic response for any dose. <br />These models can also be used to adjust for different factors such as gender, species, race, etc. <br />7<br />
    9. 9. Dose-Response Modeling<br /><ul><li>Dose-response determine interpolations between tested doses. Model selection should be based on biological considerations and well-characterized mechanisms of toxicity.
    10. 10. The multistage model postulates that a sequence of k critical sub-cellular events (mutation, changes in gene expression or cell proliferation) must occur for transformation form a normal cell to a tumor.
    11. 11. Mechanistic, biologically based or biologically motivated dose-response models attempt to model the dose to disease process in more detail. The hope is that it will provide a better understanding of the true shape of the dose-response curve and better basis for extrapolating results from lab animals to humans.</li></ul>8<br />
    12. 12. 9<br />Dose-Response Modeling<br />Monotonic dose-response models can be expressed using a simple concept that is known as tolerance distribution. <br /> Assumes that each individual has a specific tolerance for a certain toxicant and when exposed at that level or above, the disease will develop in the individual.<br />The opposite will occur if the exposure level is below the tolerance and the disease will not develop.<br />
    13. 13. 10<br />
    14. 14. 3.Exposure Assessment:<br />This includes the estimation or measurement of the:<br /> magnitude<br /> duration<br /> timing of human exposures of the agent of concern.<br /> The routes of exposure and exposed populations are required to complete the exposure assessment. <br />11<br />
    15. 15. 4.Risk Characterization:<br />Finally, risk characterization consists of combining the information from the other steps in order to estimate the level of response for the identified health effect at the specific level of exposure to the specified agent for the defined population.<br />Mathematically, the risk is calculated by substituting the specific dose amount into the dose-response equation to compute the response level.<br />12<br />
    16. 16. Risk Management<br />De Minimus Risk: This is the idea that some risks are so small that that they are acceptable or insignificant from a societal perspective.<br />Risk-Benefit Analysis: Sometimes risk is the result of activities that are otherwise beneficial that is why it is important to make risk assessments while taking benefits into account.<br />Cost-Benefit Analysis: This type of analysis is always a concern and is a requirement of certain environmental health regulations. <br />Decision Analysis or Alternatives Analysis: Obviously, the best decisions are made after considering all the relevant potential consequences rather than focusing on only particular consequences. <br />The Precautionary Principle: This idea suggests that serious risks should be avoided or mitigated when possible, even when those risks are unlikely or uncertain. It is most useful for situation where little information is available.<br />13<br />
    17. 17. 14<br />
    18. 18. Uncertainty Analysis<br />There are two approaches to such analysis: internal and probabilistic.<br />Internal: This approach is to estimate the risk twice, once using best-case parameter estimates and then again using worst-case parameter estimates. The advantage is that it is simple, easy to explain and potentially provides useful quantitative information. The disadvantage is that it provides no information about the relative plausibility of individual risk estimates within the interval.<br />Probabilistic: This approach describes risk using one or more probability distributions indicating the plausibility of an entire range of risk estimates. It has been argued that the relative plausibility of an entire range of risk estimates is impossible to determine reliably and that such attempts may mislead and confuse risk managers and stakeholders.<br />15<br />
    19. 19. 16<br />
    20. 20. Criticism<br />Controversy often arises over:<br /><ul><li>the use of conservative default assumptions in exposure assessment and dose-response assessment
    21. 21. the inadequacy of data and models for assessing affects
    22. 22. … and the wisdom for basing policy decisions on highly uncertain risk estimates.</li></ul>It is challenged because of the judgments, the untested hypotheses and the default values that are relied on in the absence of clear evidence.<br />In summary, risk assessment is susceptible to criticism because it is an attempt either to estimate unmeasured past or present or to predict an unknown future. <br />17<br />
    23. 23. Exposure Assessment<br /> Exposure Assessment, Industrial Hygiene and Environmental Management<br />Discussion Topics<br />Industrial Hygiene vs. Exposure Assessment<br />Anticipation, Recognition, Evaluation and Control<br />Exposure Assessment<br />18<br />
    24. 24. Industrial Hygiene vs. Exposure Assessment<br />Industrial hygiene and exposure assessment share a common task: quantifying hazardous exposures. However, they approach this task in different ways. <br />An industrial hygienist would typically monitor air levels of hazardous solvents and if they were excessive, solutions would be implemented. <br />An exposure assessor would specialize only in measuring and quantifying exposures and responsibility for controlling excessive exposures would rest with other professionals.<br />19<br />
    25. 25. Anticipation<br />Anticipation can be thought of as the pre-preliminary assessment made prior to going into the field. Prior to being in the field, information is reviewed and a preliminary list of potential health and safety hazards can be developed.<br />Traditionally, an industrial hygienist is called upon to evaluate safety hazards such as chemical storage that poses a threat of fire or explosion, health hazards such as high noise levels or elevated temperatures (physical hazards) as well as acute high level exposure to highly toxic chemicals such as chlorine gas (chemical hazards).<br />Anticipation, Recognition, Evaluation and Control<br />20<br />
    26. 26. Recognition<br />The initial recognition of the hazards is completed through a visual inspection (site visit or walk-through) of the facility. The purpose of the visual inspection is to gather both qualitative and quantitative information about the occupational and environmental hazards associated with the facility.<br />As the walk-through or site visit is being conducted, recognition of the sub-populations is also occurring. <br />Different groups of the facility may be exposed to different hazards (ergonomic hazards as opposed to heat stress).<br />At the conclusion of the visual inspection, the goal is to have a detailed picture of the manufacturing processes and of the associated hazards as well as a plan for evaluating these hazards. <br />The plan is to be in writing and the next phase, evaluation can be started<br />21<br />Anticipation, Recognition, Evaluation and Control<br />
    27. 27. Evaluation<br />In small facilities or where required, a census sample is taken and then all potentially expose individuals are monitored. And last, a third population, the anecdotal or convenience sample is used. This sample consists of volunteers or individuals with particular complaints. Such sampling is subject to bias and should be avoided.<br />There are two types of instruments available for measuring environmental exposures; they are direct reading instruments and sample collection instruments. <br />Direct reading instruments are useful for measuring physical hazards, such as temperature, noise and radiation. They can also be sued to measure levels of many airborne pollutants (gases, vapors and particles).<br />Sample collection instruments are used when multiple airborne pollutants are present or further analysis of samples is desirable. <br />22<br />
    28. 28. Control<br />The hygienist can take several approaches to changing the workplace through substitution, isolation and ventilation. <br /> Substitution involves replacing a hazardous material or process with a less hazardous one. <br /> Isolation involves containing or limiting access to the hazardous process.<br /> Ventilation (introduction of fresh air, local exhaust ventilation or introduction of cool air to a hot location) is used for certain hazards such as chemical or heat-related hazards.<br />Protective devices are used to control safety hazards. Personal protective equipment such as respirators, safety glasses or hard hats may also be recommended. <br />Another option available for control is through administrative strategies. For example, rotating workers through dangerous jobs will limit an individual’s aggregate exposure.<br />23<br />
    29. 29. Time course is an important factor of exposure because some contaminants are relatively readily metabolized at low levels of exposures but toxic at higher levels of exposure. As such, the dose rate may affect the health outcome. <br />To account for such differences, exposure assessors focus on magnitude, frequency and duration.<br />Exposures are also characterized as acute or chronic exposures. <br />Chronic exposures occur over months, years, or even decades and at low levels may manifest non-acute health outcomes.<br />Acute exposures are brief and when they occur at high levels, poisoning or other acute responses may follow. <br />24<br />Exposure Assessment<br />
    30. 30. 25<br />Routes and Pathways<br />There are three principal routes of exposure for contaminants to enter the body: <br />inhalation<br />ingestion <br />dermal contact. <br />These are different from the exposure pathway, which is the path by which the contaminant moves from one source to a human receptor.<br />
    31. 31. Researchers use indirect exposure assessment methods that forgo direct measurements of the exposures of interest or that use partial data. <br />Another method is called exposure scenarios in which an activity pattern for an individual is assumed and available data is used to make estimates. <br />Indirect exposure assessment is also made through a process called job-exposure matrix. <br />26<br />Assessment Methods<br />
    32. 32. 27<br />
    33. 33. 28<br />Measuring Environmental Exposure<br />Constant measuring occurs to allow for detailed exposure information which can be used for public education/warnings, to monitor the success of interventions and to support public health research.<br />Assessment Methods<br />
    34. 34. 29<br />Measuring Personal Exposures<br /> This involves outfitting an individual with monitoring equipment that measures the exposures that occur during daily activities. It allows for exact exposures to be measured and assessed.<br />Assessment Methods<br />
    35. 35. Ingestion<br />One approach is to collect duplicate portions of food that is eaten and complete an analysis or duplicate diet study. <br />Second approach is to have individuals keep dietary journals. The same foods will be purchased and brought to a lab for analysis.<br />Skin Absorption: This is much more difficult to measure.<br />One method is to have individuals wear a patch on the skin where absorption of the material of interest occurs. <br />Another method is to use the skin of a cadaver.<br />30<br />Assessment Methods for Ingestion and Skin Absorption<br />
    36. 36. 31<br />Measuring Biomarkers:<br />In order to measure the exposure levels in an individual is through the use of biological markers. <br /> Same biological material such as feces, hair, exhaled breath, urine or blood is gathered and used for analysis of actual human exposure.<br />Assessment Methods<br />
    37. 37. 32<br /><ul><li>In the US, occupational injury death per year is between 5,000 to 6,000 however, occupational illness leading to death is 49,000 to 65,000 per year.
    38. 38. Globally, the data gets worse as more hazards are introduced in poorer nations.
    39. 39. In the poorest of nations not only are the hazards greater but the lack of data is a significant issue.</li></li></ul><li>33<br />
    40. 40. 34<br />
    41. 41. 35<br />
    42. 42. 36<br />
    43. 43. 37<br />
    44. 44. 38<br />
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