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    Bio Jc Bio Jc Document Transcript

    • !"#$%&(")*$+&,-./& !0120-3& .4& 5665& 21789& !293& .4& 566:;& <& =0>& ?/@9.3?A& B3& $C@?-801& D"& 9.E07?A&81& "99?1;& +FG& & <& >70-7?A& 0>& 0& .1>2/?-& %2@@.-7& ">>.E807?;& -?>@.1A81H& 7.& E.1>2/?-&E./@90817>& I80& /089& 01A& 7?9?@J.1?G& & <& I.9217??-?A& 4.-& 0& 51A& >J847& @-.H-0/;& =.-K81H&4-./& LML6@/NO5M660/& 01A& 7J8>& 099.=?A& /?& 7.& P2/@& 0J?0A& .4& /3& E.N=.-K?->& 01A& H?7&@-./.78.1>&7.&B?81H&B.7J&4-02A&01A&/8C?A&489?&7-081?AG&&+J8>&2>20993&70K?>&5NL&3?0->;&B27&<& J0A&87& A.1?&81& Q& /.17J>G&& "@@-.C8/07?93&:&/.17J>&907?-;& 0&@.>878.1& .@?1?A&2@& 81& 7J?&$987?&.1>2/?-&"4408->&%@?E809&%?-I8E?>&R"%%S&T?@0-7/?17&01A;&047?-&0&9?1H7J3&I?7781H&@-.E?>>;&<&=0>&.44?-?A&01A&0EE?@7?A&7J?&@.>878.1G&&+J?& "%%& A?@0-7/?17& 8>& 7J?& J?0A& .4& 7J?& 9?H09& 01A& E./@9801E?& 7?0/& 4.-& $C@?-801;&097J.2HJ& 1.7& @0-7& .4& 7J?& ?C?E278I?& 7?0/;& 87& 8>& 7J?& 0AP27017& 7.& 7J?& $C?E278I?& 7?0/& 7J07&J01A9?>&099&?C7?-109&?C?E278I?&U2?-8?>V&>J8?9A81H&7J?&?C?E278I?>&4-./&7J?&H?1?-09&@2B98EG&&<1&0AA878.1;&"%%&8>&7J?&A?@0-7/?17&7J07&J01A9?>&7J?&0@@98E078.1&.4&90=>&7.&7J?&817?-109&@.98E8?>&.4&$C@?-801G&&<1&7J07&-.9?;&=?&=?-?&-?E.H18W?A&0>&?C@?-7>&.1&7J?&,)"&01A&7J?&=.-K81H>&.4&7J?&-?A87&)?@.-781H&0H?1E8?>G&&">&>2EJ;&=?&=?-?&E099?A&2@.1&7.&7?>7843&81&E.2-7& 0>& $C@?-801;& -?@-?>?17& $C@?-801& 81& >/099& E908/>& E.2-7;& -?>@.1A& 7.& 81U28-8?>& 4-./&7J?& X%& .1H-?>>;& B.7J& 0>& 0& =J.9?& 01A& 81A8I8A20993;& -?>@.1A& 7.& 814.-/078.1& -?U2?>7>&4-./&7J?&,+&01A&7J?&7-?0>2-3&A?@0-7/?17;&-?>@.1A&7.&B.7J&1078.109&01A&>707?&"77.-1?3&Y?1?-09&81U28-8?>;&01A&E..-A8107?&099&.4&.2-&H.I?-1/?1709&04408->&=87J&.2-&9.BB38>7>G&"9>.;&=J?1?I?-&$C@?-801&=0>&7J-?07?1?A&=87J&0&90=>287;&-?E?8I?A&0&E./@90817&4-./&7J?&Z?77?-&Z2>81?>>&Z2-?02;&-?E?8I?A&0&E./@90817&21A?-&7J?&X;&.-&-?E?8I?A&0&>2B@.?10;&"%%&=0>&70>K?A&=87J&-?>@.1A81HG&&<1& !293& .4& 566:;& <& EJ.>?& 7.& 9?0I?& $C@?-801& 01A& H.& 817.& 7J?& E-?A87& -?>7.-078.1& 81A2>7-3G& &+J?&@-8/0-3&-?0>.1&4.-&7J8>&EJ01H?&=0>&7J07;&047?-&3?0->&.4&=.-K81H&7J?-?;&<&-?098W?A&7J07&097J.2HJ&E-?A87&-?@.-781H&0H?1E8?>&01A&E-?A87.->&=.29A&98K?&4.-&E98?17>&7.&077?/@7&7.&=.-K&.1&7J?8-&E-?A87&-?@.-7>&7J?/>?9I?>;&87&8>&0&1?0-&8/@.>>8B89873&4.-&7J?/&7.&H?7&7J-.2HJ&7J?&-?A&70@?&7J07&?C8>7>&7.&-?0993&E.--?E7&7J?&/297872A?&.4&?--.->&7J07&?C8>7G&&">&=?99;&/013&.4&7J?& 90=>& 0-?& =89942993& 1.7& 4.99.=?A;& ?>@?E80993& B3& 7J?& E-?A87.->;& 01A& 7J?-?& 0-?& I?-3& 4?=&81A8I8A209>&.27&7J?-?&7J07&=017&7.&48HJ7&4.-&E.1>2/?->G&&%?I?-09&3?0->&0H.;&7J?-?&=0>&0&EJ8?4&.4&7J?&,+&7J07&>08A&87&=0>&@.>>8B9?&7.&J0I?&0&H..A&E-?A87&-?@08-&E./@013;&B27&7J07&J?&J0A&1?I?-&>??1&.1?G&&#3&?C@-?>>?A&H.09&8>&7.&J0I?&01&.-H018W078.1&7J07&=899&?CE??A&J8>& -?U28-?/?17>& 01A& B?& 0& 4.-E?& 4.-& 7J?& H..A& .4& 81A8I8A209>& 0H081>7& .-H018W078.1>& =J.&A.1[7&E0-?&0B.27&@-.7?E781H&E.1>2/?-[>&-8HJ7>G&&!"#$%&(")*$+
    •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`>&E-?A87&-?@.-7G&+J07&8>&?C0E793&J.=&7J?&E-?A87&-?@.-781H&0H?1E8?>&01A&7J?8-&-?09&E98?17>;&7J?&E-?A87.->;&@-?4?-&87G9"*2$:*44#+.$9"#+$;-/$<+=#.2(5*2#$*+$%))-/+2$9(2"$*$,#1(2$3#4-2(+5$%5#+)>?6(+*+)#7$,#1(2&&]2B98>J?AM&%?@7?/B?-&5O;&566a+J?-?&0-?&E./@018?>&01A&.-H018W078.1>&7J07&/0K?&.27-0H?.2>&E908/>&7J07&7J?3&E01&8/@-.I?&3.2-&E-?A87&81&5&.-&7J-??&A03>G&+J?>?&0-?&.BI8.2>93&409>?G&Z27&=J07&0-?&7J?&0E7209&78/?&4-0/?>&4.-&81I?>78H078.1>&=87J&0&E-?A87&-?@.-781H&0H?1E3b&&&&9"*2$@-2$2-$A#B(#=#
    • 6(+*+)#7$,#1(2&&]2B98>J?AM&!21?&_;&566c%.&/2EJ&814.-/078.1&?C8>7>&?>@.2>81H&.@818.1>&0B.27&7J?&E-?A87&-?@.-781H&81A2>7-3&01A&=J07&E.1>2/?->&>J.29A& 01A& >J.29A& 1.7& A.& 7.& 8/@-.I?& 7J?/>?9I?>& 7J07& 87& 8>& >./?78/?>& A8448E297& 7.& K1.=& 4.-& >2-?& =J07& 8>&H..A& 0AI8E?& 01A& =J07& 8>& 1.7G& .//.1& @874099>& E.1>2/?->& /03& ?1E.217?-& 0-?& ?C?/@9848?A& 81& 7J8>& 0-78E9?&09.1H&=87J&?C0/@9?>&.4&=J3&7J?&H8I?1&0AI8E?&/03&.-&/03&1.7&B?&0@@98E0B9?&81&0&I0-8?73&.4&>872078.1>G9"#+$:#B4(+5$*$6(#+1$(.$@-2$%BC*>.$2"#$A#.2$!"(+5$2-$8-6(+*+)#7$,#1(2&&]2B98>J?AM&#0-EJ&5a;&566c#.>7&@?.@9?&J0I?&87&81&7J?8-&1072-?&7.&0>>8>7&0&4-8?1A&81&1??AG&(.=?I?-;&=J?1&87&E./?>&7.&E-?A87;&7J?-?&8>&0&-8HJ7&=03&01A&0&=-.1H&=03&7.&9?1A&0&J?9@81H&J01A;&01A&7J?&=-.1H&=03&E01&B?&/.-?&E.>793&7J01&/013&@?.@9?&-?098W?G%#$%BB$D*2#$E*>&#+2.$3#*BB>$,#*2#1$FG/*B?6(+*+)#7$,#1(2&&]2B98>J?AM&#0-EJ&5a;&566c-?A87&>E.-?>&0-?&2>20993&-?4?--?A&7.&0>&0&>81H9?;&2B8U287.2>&?17873G&Z27;&81&0E7209873;&7J?-?&0-?&0&/297872A?&.4& A844?-?17& /.A?9>& 01A& 4.-/290>& 7J07& ?C8>7;& 01A& 7J?& .1?& 7J07& 0& 9?1A?-& EJ..>?>& E01& /0K?& 0>& /2EJ& .4& 0&A844?-?1E?&81&3.2-&48109&>E.-?&0>&3.2&0E7209&J8>7.-3&A.?>GE-2#)2(+5$,"(B1#+$A#H-#$*+1$%H2#$<8$!"#H26(+*+)#7$,#1(2&&]2B98>J?AM&#0-EJ&55;&566cJ89A-?1&/03&>??/&98K?&7J?&/.>7&2198K?93&I8E78/>&.4&8A?17873&7J?47;&B27&0E720993&?1A&2@&B?81H&I8E78/8W?A&07&/2EJ& J8HJ?-& -07?>& 7J01& 7J?& H?1?-09& @.@29078.1G& +J?-?& 0-?;& J.=?I?-;& >./?& I?-3& >8/@9?& =03>& 7.& E./B07&7J8>&@-.B9?/G!"#$<&4-2*+)#$-H$*$I--1$,#1(2$A#5(++(+56(+*+)#7$,#1(2&&]2B98>J?AM&#0-EJ&Oa;&566c+J?-?& 8>& 0& /8>E.1E?@78.1& 0/.1H& /2EJ& .4& 7J?& H?1?-09& @2B98E& 7J07& ?I?-3.1?& >70-7>& =87J& 0& @?-4?E7& E-?A87&>E.-?&01A&=J07&7J?3&A.&4-./&7J?-?&B-81H>&87&A.=1G&<1&-?09873;&81A8I8A209>&B?H81&=87J&1.=&.-&?CE?@78.10993&9.=&E-?A87&>E.-?>&01A&0-?&-?U28-?A&7.&H.&7.&H-?07&9?1H7J>&7.&B289A&7J?8-&J8>7.-3&01A&A?E-?0>?&7J?&-8>K&7J?3&@.>?&7.&9?1A?->G&&&,/#+2$<&4-2*+2$<+H-&*2(-+$J$K)2L$MN$OPQQN$9*."(+52-+$8,
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