4. INTRODUCTION
(selective beta 2 agonist : duration 3-5hrs)
It belongs to
adrenergic
class
Beta 2
agonist
Causes
bronchodilation
5. Mechanism of
Action
• Act directly on B2-receptors that are
located on:
o Peripheral Blood Vessels,
o Bronchi,
o GIT,
o Skeletal Muscle,
o Liver,
o Mast cell.
7. Actions
• Activation results in:
o Bronchodilation,
o Relaxation of the GIT,
o Glycogenolysis in the liver,
o Inhibition of histamine release from mast cells.
8. Indications
• Bronchial Asthma
• Bronchospasm
• COPD
•Pre-mature Labor
In Sports, used by
runners, cyclists,
swimmers, etc. to
increase oxygen
uptake and cardiac
function.
17. Common (1 in 100 people)
Shaking, usually of the hands (tremor).
Headache.
Faster than normal heartbeat (tachycardia).
Uncommon (1 in 1000 people)
Heart palpitations
Muscle cramps
Mouth and throat irritation
18. Rare (1 in 10,000 people)
Low level of potassium in your blood (Hypokalemia).
Very rare (1 in 10,000 people)
Irregular heartbeat (Arrhythmia).
Unexpected narrowing of the airways (Paradoxical
Bronchospasm).
20. Contraindications
Hypersensitivity to the active substance salbutamol or to the
excipients.
Although some forms of salbutamol sulphate have been used in
the management of premature labor, Salbutamol Nebuliser
Solution should not be used for this purpose.
21. DRUG INTERACTIONS
Salbutamol will enhance the activity of other β2 sympathomimetics.
β receptor blocking agents such as propranolol inhibit the activity of
salbutamol.
The effects of salbutamol may be enhanced by concomitant administration
of aminophylline or other xanthines.
Corticosteroids may increase the risk of hyperglycaemia.
26. Patient Care Considerations
Administration / storage.
Patients with severe attack of asthma should have oxygen.
Inform the patient that Albuterol may cause an unusual
dryness or bad taste.
Dose and frequency of inhalation adjustment.
Warn about over dependence.