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Transport Of Oxygen 2

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  • 1. Transport of Oxygen 2 The Bohr effect Fetal haemoglobin Myoglobin
  • 2. Transport of Oxygen 2
    • Hb is even more efficient that suggested by the dissociation curve
    • The amount of O 2 carried by Hb depends not only on the p O 2 but also the partial pressure of carbon dioxide .
  • 3. Transport of Oxygen 2
    • At the tissues there is high [carbon dioxide] this reduces Hb affinity for oxygen so it gives it up.
    • Conversely at lungs there is low [carbon dioxide] so the Hb has a greater affinity for oxygen – so picks up more.
  • 4.  
  • 5.
    • The result is thus, that under the same blood pO 2 conditions, high levels of CO 2 (acidic conditions) will unload more O 2 from the Hb
    • Oxyhaemoglobin releases its oxygen where it is most needed: to the actively respiring tissues.
    Transport of Oxygen 2
  • 6. Transport of Oxygen 2
    • The further the dissociation curve moves to the right, the more readily Hb gives up its oxygen.
  • 7. Transport of Oxygen 2
    • The further the dissociation curve moves to the left, the more readily Hb picks up oxygen.
  • 8. Fetal haemoglobin
    • The developing fetus obtains oxygen from its mum
    • Fetal and maternal blood run close together but never mix
    • This allows materials to diffuse from the blood of mum into the fetus and vice versa. .
  • 9. Fetal haemoglobin
  • 10. Fetal haemoglobin
    • The dissociation curve of fetal Hb is to the left of adult Hb
    • This means fetal Hb combines with oxygen more readily than adult Hb
    • Fetal Hb has a higher affinity for oxygen.
  • 11. Fetal haemoglobin
    • At the placenta the fetal haemoglobin can ‘steal’ oxygen form the maternal haemoglobin.
  • 12. Myoglobin
    • In muscle there is another oxygen binding molecule called myoglobin .
    • Oxymyoglobin is much more stable than oxyhaemoglobin
  • 13. Myoglobin
    • Myoglobin will only give up its oxygen at very low oxygen partial pressures.
  • 14.  
  • 15. Myoglobin
    • The myoglobin dissociation curve is a long way to the left of Hb.
    • At each partial pressure of oxygen, myoglobin holds onto much more oxygen than Hb.
  • 16. Myoglobin
    • This enables myoglobin to act as an oxygen store.
    • Usually respiring muscle will get its oxygen from oxyhaemoglobin
    • Only if the partial pressure of oxygen falls very low will oxymyoglobin release its oxygen