Transport Of Oxygen 2
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Transport Of Oxygen 2






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    Transport Of Oxygen 2 Transport Of Oxygen 2 Presentation Transcript

    • Transport of Oxygen 2 The Bohr effect Fetal haemoglobin Myoglobin
    • Transport of Oxygen 2
      • Hb is even more efficient that suggested by the dissociation curve
      • The amount of O 2 carried by Hb depends not only on the p O 2 but also the partial pressure of carbon dioxide .
    • Transport of Oxygen 2
      • At the tissues there is high [carbon dioxide] this reduces Hb affinity for oxygen so it gives it up.
      • Conversely at lungs there is low [carbon dioxide] so the Hb has a greater affinity for oxygen – so picks up more.
      • The result is thus, that under the same blood pO 2 conditions, high levels of CO 2 (acidic conditions) will unload more O 2 from the Hb
      • Oxyhaemoglobin releases its oxygen where it is most needed: to the actively respiring tissues.
      Transport of Oxygen 2
    • Transport of Oxygen 2
      • The further the dissociation curve moves to the right, the more readily Hb gives up its oxygen.
    • Transport of Oxygen 2
      • The further the dissociation curve moves to the left, the more readily Hb picks up oxygen.
    • Fetal haemoglobin
      • The developing fetus obtains oxygen from its mum
      • Fetal and maternal blood run close together but never mix
      • This allows materials to diffuse from the blood of mum into the fetus and vice versa. .
    • Fetal haemoglobin
    • Fetal haemoglobin
      • The dissociation curve of fetal Hb is to the left of adult Hb
      • This means fetal Hb combines with oxygen more readily than adult Hb
      • Fetal Hb has a higher affinity for oxygen.
    • Fetal haemoglobin
      • At the placenta the fetal haemoglobin can ‘steal’ oxygen form the maternal haemoglobin.
    • Myoglobin
      • In muscle there is another oxygen binding molecule called myoglobin .
      • Oxymyoglobin is much more stable than oxyhaemoglobin
    • Myoglobin
      • Myoglobin will only give up its oxygen at very low oxygen partial pressures.
    • Myoglobin
      • The myoglobin dissociation curve is a long way to the left of Hb.
      • At each partial pressure of oxygen, myoglobin holds onto much more oxygen than Hb.
    • Myoglobin
      • This enables myoglobin to act as an oxygen store.
      • Usually respiring muscle will get its oxygen from oxyhaemoglobin
      • Only if the partial pressure of oxygen falls very low will oxymyoglobin release its oxygen