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Carbon Dioxide Transport
Carbon Dioxide Transport
Carbon Dioxide Transport
Carbon Dioxide Transport
Carbon Dioxide Transport
Carbon Dioxide Transport
Carbon Dioxide Transport
Carbon Dioxide Transport
Carbon Dioxide Transport
Carbon Dioxide Transport
Carbon Dioxide Transport
Carbon Dioxide Transport
Carbon Dioxide Transport
Carbon Dioxide Transport
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Carbon Dioxide Transport

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  • 1. Transport of carbon dioxide H +
  • 2. Transport of carbon dioxide H +
    • CO 2 is carried in three ways:
    • 5% carried in solution in the plasma as CO 2
    • 10% combines with the Hb in the form of carbamino-haemoglobin
    • 85% is carried as hydrogen carbonate
  • 3. Transport of carbon dioxide
    • The way in which hydrogen carbonate is formed is important and needs to be known in detail.
  • 4. Transport of carbon dioxide
    • In tissue :
    CO 2 plasma
  • 5. Transport of carbon dioxide
    • In tissue :
    + H 2 O H + + HCO 3 - plasma CO 2 enzyme
  • 6. Transport of carbon dioxide
    • In lungs:
    HCO 3 - plasma
  • 7. Transport of carbon dioxide
    • In lungs:
    CO 2 + H 2 O H + + HCO 3 - plasma enzyme
  • 8. Transport of carbon dioxide
    • In lungs:
    CO 2 + H 2 O H + + HCO 3 - plasma enzyme
  • 9. Formation of hydrogen carbonate
    • CO 2 diffuses from tissues into rbc
    • Some combines with amino groups to form carbamino-haemoglobin
    • The RBC contain an enzyme called carbonic anhydrase which catalyses the reaction between CO 2 and water to form carbonic acid
  • 10. Formation of hydrogen carbonate
    • Carbonic acid dissociates into negatively charged hydrogen carbonate and positive hydrogen ions
    • The hydrogen ions increase the acidity of the blood
    • The H + combine with Hb to give haemoglobinic acid .
    • This decreases the affinity of Hb to oxygen so it gives it up to the tissues (hence the Bohr effect)
  • 11. Formation of hydrogen carbonate
    • The build up of hydrogen carbonate ions causes them to diffuse out of the RBC leaving the inside of the RBC positively charged.
    • In order to balance this electric charge chloride ions diffuse into the rbc from the plasma – this is known as the chloride shift.
    • In this reaction Hb is acting as a buffer
  • 12.  
  • 13.  
  • 14. Formation of hydrogen carbonate
    • When blood gets to the lungs, all the reactions are reversed
    • The hydrogen carbonate and hydrogen ions recombine releasing CO 2
    • The chloride shift is reversed
    • Carbamino-haemoglobin breaks down to release CO 2

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