NETWORK INTELLIGENCE     WITH SCIBITEDELIVERING CRITICAL BUSINESSINSIGHTS FOR PHARMA AND BIOTECHHTTP://SCIBITE.COM@ S C I ...
Aim: Demonstrate how SciBite network views enable rapid  understanding of “hot” areas concerning a target, drug,  disease ...
The GSK News NetworkTarget Drug Indication Company
Zoom in on an interesting cluster
By simply zooming in on the region, one can immediatelyunderstand a relationship between GSK and Cephalon in theLeukemia/L...
What about this cluster?                                     Its clear there is a strong relationship with GSKGabapentin E...
Another cluster, again seems like astrong relationship                                  Immediately see how they are conne...
OK, Tell me something interesting……                                    GSK/Ligand collaboration for                       ...
Using network analysis we were able to gain a very rapid overview of the activity landscape for    Glaxosmithkline (GSK)Cl...
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Scibite network intelligence

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A short slide deck demonstrating the use of network analysis of SciBite data via the cytoscape software. The slides show how one can get a "birds-eye-view" of recent activity covering an entire topic, such as a pharma company or new drug.

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Transcript of "Scibite network intelligence"

  1. 1. NETWORK INTELLIGENCE WITH SCIBITEDELIVERING CRITICAL BUSINESSINSIGHTS FOR PHARMA AND BIOTECHHTTP://SCIBITE.COM@ S C I B I T E LY[C]2012 SCIBITE. REPRODUCTION BY ANY MEANS IS PROHIBITED.
  2. 2. Aim: Demonstrate how SciBite network views enable rapid understanding of “hot” areas concerning a target, drug, disease or company.Example: You want to understand current activity around a particular company – here GlaxoSmithKline (GSK) is used but the same approach applies to any target, company, indication, drug or even miRNA, pathway, technology…Source: Any article (literature, blogs, news, patents, grants, trials) from the last 6 months that mentions GSK along with other high-confidence associations between Genes, Drugs, Indications and CompaniesResults: Visualised in Cytoscape
  3. 3. The GSK News NetworkTarget Drug Indication Company
  4. 4. Zoom in on an interesting cluster
  5. 5. By simply zooming in on the region, one can immediatelyunderstand a relationship between GSK and Cephalon in theLeukemia/Lymphoma area. The relationship is competitive, withArzerra (GSK) and Bendamustine (Trenda, Cephalon) for the sameindication (CLL)
  6. 6. What about this cluster? Its clear there is a strong relationship with GSKGabapentin Enacarbil for neuralgiaGSK/XenoPort collaboration
  7. 7. Another cluster, again seems like astrong relationship Immediately see how they are connected.
  8. 8. OK, Tell me something interesting…… GSK/Ligand collaboration for ThrombocytopeniaBut why is Eltrombopagconnected to Leukemia?Answer: New study from the USshows inhibits leukemia cellproliferation.Repurposing Opportunity?
  9. 9. Using network analysis we were able to gain a very rapid overview of the activity landscape for Glaxosmithkline (GSK)Clusters of companies, drugs and indications allow us to understand who GSK is competing with, in what areasThe visual display of data makes it easy to see where larger areas of activity are, and identify highly related targets, drugs, companies and indicationsLooking closely at clusters enables us to acknowledge the topics we know of and delve deeper into those of which we might be unaware. As in the case of Eltrombopag, the network view allowed us to identify novel connections and potential repurposing opportunities.In conclusion, network analysis with SciBite provides an unprecedented picture of the activity landscape on any major drug discovery topic.If you’re interested in learning more, please contact us at info <at> scibite.comThanks for reading!
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