Your SlideShare is downloading. ×
The Chemical Level of Organization
Upcoming SlideShare
Loading in...5

Thanks for flagging this SlideShare!

Oops! An error has occurred.

Saving this for later? Get the SlideShare app to save on your phone or tablet. Read anywhere, anytime – even offline.
Text the download link to your phone
Standard text messaging rates apply

The Chemical Level of Organization


Published on

Published in: Education, Technology
  • Be the first to comment

No Downloads
Total Views
On Slideshare
From Embeds
Number of Embeds
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

No notes for slide


  • 1. Chapter 2: The Chemical Level of Organization
  • 2. Introduction
    • Since chemicals compose your body and all body activities are chemical in nature, it is important to become familiar with the language and fundamental concepts of chemistry.
  • 3. How Matter is Organized
    • Chemical Elements
      • All forms of matter are composed of chemical elements which are substances that cannot be split into simpler substances by ordinary chemical means.
      • Elements are given letter abbreviations called chemical symbols .
      • Trace elements are present in tiny amounts
  • 4. Structure of Atoms
    • Units of matter of all chemical elements are called atoms . An element is a quantity of matter composed of atoms of the same type.
    • Atoms contain:
    • Nucleus: protons (p+) & neutrons (neutral charge)
    • Electrons (e-) surround the nucleus as a cloud (electron shells are designated regions of the cloud)
  • 5. 2 Representations of the Structure of an Atom
  • 6. Atomic Number and Mass Number
    • Atomic number is number of protons in the nucleus.
    • Mass number is the sum of its protons and neutrons.
  • 7.  
  • 8. Atomic Mass
    • Mass is measured as a dalton (atomic mass unit)
    • Neutron has mass of 1.008 daltons
      • proton has mass of 1.007 daltons
      • electron has mass of 0.0005 dalton
    • Atomic mass (atomic weight) is close to the mass number of its most abundant isotope.
  • 9. Atomic Number and Mass Number
    • Atomic Mass
      • The atomic mass , also called the atomic weight, of an element is the average mass of all its naturally occurring isotopes and reflects the relative abundance of isotopes with different mass numbers.
      • The mass of a single atom is slightly less than the sum of the masses of its neutrons, protons, and electrons because some mass (less than1%) was lost when the atom’s components came together to form an atom.
  • 10. Ions, Molecules, & Compounds
    • Ions
      • an atom that gave up or gained an electron
      • written with its chemical symbol and (+) or (-)
    • Molecule
      • atoms share electrons
      • written as molecular formula showing the number of atoms of each element (H 2 O)
  • 11. Free Radicals
    • A free radical is an electrically charged atom or group of atoms with an unpaired electron in its outermost shell
    • Unstable and highly reactive; can become stable
      • by giving up an electron
      • taking an electron from another molecule
      • Antioxidants are substances that inactivate oxygen-derived free radicals
  • 12. Chemical Bonds
    • The atoms of a molecule are held together by forces of attraction called chemical bonds .
    • The likelihood that an atom will form a chemical bond with another atom depends on the number of electrons in its outermost shell, also called the valence shell.
  • 13. Ionic Bonds
    • When an atom loses or gains a valence electron, ions are formed (Figure 2.4a).
      • Positively and negatively charged ions are attracted to one another.
      • Cations are positively charged ions that have given up one or more electrons (they are electron donors).
      • Anions are negatively charged ions that have picked up one or more electrons that another atom has lost (they are electron acceptors).
  • 14. The Ionic Bond Formation
  • 15. Covalent Bonds
    • Covalent bonds are formed by the atoms of molecules sharing one, two, or three pairs of their valence electrons.
      • Covalent bonds are common and are the strongest chemical bonds in the body.
      • Single, double, or triple covalent bonds are formed by sharing one,two, or three pairs of electrons, respectively.
    • Covalent bonds may be nonpolar or polar.
      • In a nonpolar covalent bond, atoms share the electrons equally; one atom does not attract the shared electrons more strongly than the other atom
  • 16.  
  • 17. Polar Covalent Bonds
    • Unequal sharing of electrons between atoms. In a water molecule, oxygen attracts the hydrogen electrons more strongly
      • Oxygen has greater electronegativity as indicated by the negative Greek delta sign.
  • 18. Hydrogen Bonds
    • Approximately 5% as strong as covalent bonds
    • Useful in establishing links between molecules or between distant parts of a very large molecule
    • Large 3-D molecules are often held together by a large number of hydrogen bonds.
  • 19. Hydrogen Bonds
      • are weak inter molecular bonds; they serve as links between molecules.
      • help determine three-dimensional shape
      • give water
      • considerable cohesion which creates a very high surface tension
  • 20. Chemical Reactions
    • New bonds form and/or old bonds are broken.
    • Metabolism is “the sum of all the chemical reactions in the body.”
    • Law of conservation of energy
      • The total mass of reactants equals the total mass of the products.
  • 21. Forms of Energy and Chemical Reactions
    • Energy is the capacity to do work.
    • Kinetic energy is the energy associated with matter in motion .
    • Potential energy is energy stored by matter due to its position .
  • 22. Energy Transfer in Chemical Reactions
    • An e xergonic reaction is one in which the bond being broken has more energy than the one formed so that extra energy is released , usually as heat (occurs during catabolism of food molecules).
    • An endergonic reaction is just the opposite and thus requires that energy be added, usually from a molecule called ATP, to form a bond, as in bonding amino acid molecules together to form proteins.
  • 23. Activation Energy
  • 24. Factors that Cause a Collision and Chemical Reaction
    • Concentration
    • Temperature
    • Catalysts are chemical compounds that speed up chemical reactions by lowering the activation energy needed for a reaction to occur.
    • A catalyst does not alter the difference in potential energy between the reactants and products. It only lowers the amount of energy needed to get the reaction started.
      • A catalyst helps to properly orient the colliding particles of matter so that a reaction can occur at a lower collision speed.
      • The catalyst itself is unchanged at the end of the reaction; it is often re-used many times.
  • 25. Catalysts and chemical reactions
  • 26. Types of Chemical Reactions
    • Synthesis reactions -- Anabolism
    • Decomposition reactions-- Catabolism
    • Exchange reactions
    • Reversible reactions
  • 27. Inorganic Compounds and Solutes
    • Inorganic compounds usually lack carbon and are simple molecules; whereas organic compounds always contain carbon and hydrogen, usually contain oxygen, and always have covalent bonds.
  • 28. Water
      • Is the most important and abundant inorganic compound in all living systems.
      • Water’s most important property is polarity, the uneven sharing of valence electrons
      • Enables reactants to collide to form products
  • 29. Polar Water Molecules
  • 30. Water as a Solvent
    • In a solution the solvent dissolves the solute.
    • Substances which contain polar covalent bonds and dissolve in water are hydrophilic , while substances which contain non polar covalent bonds are hydrophobic.
    • The polarity of water and its bent shape allow it to interact with several neighboring ions or molecules.
    • Water’s role as a solvent makes it essential for health and survival.
  • 31. High Heat Capacity of Water
    • Water has a high heat capacity.
    • It can absorb or release a relatively large amount of heat with only a modest change in its own temperature.
    • This property is due to the large number of hydrogen ions in water.
    • Heat of vaporization is also high
      • amount of heat needed to change from liquid to gas
      • evaporation of water from the skin removes large amount of heat
  • 32. 3 Common Mixtures
    • A mixture is a combination of elements or compounds that are
    • physically blended together but are not bound by chemical bonds.
    • Solution : a substance called the solvent dissolves another substance called the solute. Usually there is more solvent than solute in a solution.
    • A colloid differs from a solution mainly on the basis of the size of its particles with the particles in the colloid being large enough to scatter light.
    • Suspension : the suspended material may mix with the liquid or suspending medium for some time, but it will eventually settle out.
  • 33. Concentration
    • The concentration of a molecule is a way of stating the amount of that molecule dissolved in solution.
    • Percent gives the relative mass of a solute found in a given volume of solution.
    • A mole is the name for the number of atoms in an atomic weight of that element, or the number of molecules in a molecular weight of that type of molecule, with the molecular weight being the sum of all the atomic weights of the atoms that make up the molecule.
  • 34. Dissociation of Acids, Bases, and Salts
  • 35. Concept of pH
    • pH scale runs from 0 to 14 (concentration of H+ in moles/liter)
    • pH of 7 is neutral
      • (distilled water -- concentration of OH- and H+ are equal)
    • pH below 7 is acidic ([H + ] > [OH - ]).
    • pH above 7 is alkaline ([H + ] < [OH - ]).
    • pH is a logarithmic scale
      • Example: a change of two or three pH units
      • pH of 1 contains 10x10=100 more H+ than pH of 3
      • pH of 8 contains 10x10x10=1000 more H+ than pH of 11
  • 36. The pH Scale
  • 37. Maintaining pH: Buffer Systems
    • The pH values of different parts of the body are maintained fairly constant by buffer systems, which usually consist of a weak acid and a weak base.
      • convert strong acids or bases into weak acids or bases.
  • 38.
    • Many functional groups can attach to carbon skeleton
      • esters, amino, carboxyl, phosphate groups
      • Very large molecules are called macromolecules (or “polymers” if all the monomer subunits are similar)
    • Isomers have the same molecular formulas but different structures (glucose & fructose are both C 6 H 12 O6)
    Carbon and Its Functional Groups
  • 39. Carbohydrates
    • Carbohydrates provide most of the energy needed for life and include sugars, starches, glycogen, and cellulose.
    • Some carbohydrates are converted to other substances which are used to build structures and to generate ATP.
    • Other carbohydrates function as food reserves.
    • Carbohydrates are divided into three major groups based on their size: monosaccharides, disaccharides, and polysaccharides
  • 40. Monosaccharides
  • 41. Disaccharides
    • Combining 2 monosaccharides by dehydration synthesis releases a water molecule.
      • sucrose = glucose & fructose
      • maltose = glucose & glucose
      • lactose = glucose & galactose (lactose intolerance)
  • 42. Polysaccharides
    • Polysaccharides are the largest carbohydrates and may contain hundreds of monosaccharides.
    • The principal polysaccharide in the human body is glycogen , which is stored in the liver or skeletal muscles.
    • When blood sugar level drops, the liver hydrolyzes glycogen to yield glucose which is released from the liver into the blood
  • 43. Lipids
    • Lipids , like carbohydrates, contain carbon, hydrogen, and oxygen; but unlike carbohydrates, they do not have a 2:1 ratio of hydrogen to oxygen.
    • They have few polar covalent bonds
      • hydrophobic
      • mostly insoluble in polar solvents such as water
      • combines with proteins (lipoproteins) for transport in blood
  • 44. Triglycerides
    • Triglycerides are the most plentiful lipids in the body and provide protection, insulation, and energy (both immediate and stored).
      • At room temperature, triglycerides may be either solid (fats) or liquid (oils).
      • Triglycerides provide more than twice as much energy per gram as either carbohydrates or proteins.
      • Triglyceride storage is virtually unlimited.
      • Excess dietary carbohydrates, proteins, fats, and oils will be deposited in adipose tissue as triglycerides.
  • 45. Triglycerides
  • 46. Phospholipids
    • Phospholipids are important membrane components.
    • They are amphipathic, with both polar and nonpolar regions
      • a polar head
        • a phosphate group (PO4 -3 ) & glycerol molecule
        • forms hydrogen bonds with water
      • 2 nonpolar fatty acid tails
        • interact only with lipids
  • 47.  
  • 48. Steroids
    • Steroids have four rings of carbon atoms Steroids include
      • sex hormone
      • bile salts
      • some vitamins
      • cholesterol, with cholesterol serving as an important component of cell membranes and as starting material for synthesizing other steroids.
  • 49. Four Ring Structure of Steroids
  • 50. Proteins
    • Constructed from combinations of 20 amino acids.
      • dipeptides formed from 2 amino acids joined by a covalent bond called a peptide bond
      • polypeptides chains formed from 10 to 2000 amino acids.
  • 51. Formation of a Dipeptide Bond
    • Dipeptides formed from 2 amino acids joined by a covalent bond called a peptide bond
      • dehydration synthesis
    • Polypeptides chains contain 10 to 2000 amino acids.
  • 52. Levels of Structural Organization
    • Levels of structural organization include
      • primary
      • secondary
      • tertiary
      • quaternary
    • The resulting shape of the protein greatly influences its ability to recognize and bind to other molecules.
    • Denaturation of a protein by a hostile environment causes loss of its characteristic shape and function.
  • 53.  
  • 54. Enzymes
    • Catalysts in living cells are called enzymes .
    • Enzymes are highly specific in terms of the “substrate” with which they react.
    • Enzymes are subject to variety of cellular contro ls.
    • Enzymes speed up chemical reactions by increasing frequency of collisions, lowering the activation energy and properly orienting the colliding molecules.
  • 55. How and Enzyme Works
  • 56. DNA and RNA
    • Nucleic acids are huge organic molecules that contain carbon, hydrogen, oxygen, nitrogen, and phosphorus.
    • Deoxyribonucleic acid (DNA) forms the genetic code inside each cell and thereby regulates most of the activities that take place in our cells throughout a lifetime.
    • Ribonucleic acid (RNA) relays instructions from the genes in the cell’s nucleus to guide each cell’s assembly of amino acids into proteins by the ribosomes.
    • The basic units of nucleic acids are nucleotides, composed of a nitrogenous base, a pentose, sugar, and a phosphate group .
  • 57.  
  • 58. RNA Structure
    • Differs from DNA
      • single stranded
      • ribose sugar not deoxyribose sugar
      • uracil nitrogenous base replaces thymine
    • Types of RNA within the cell, each with a specific function
      • messenger RNA
      • ribosomal RNA
      • transfer RNA
  • 59. Adenosine Triphosphate (ATP)
    • Temporary
    • molecular storage of
    • energy as it is being
    • transferred from
    • exergonic catabolic
    • reactions to cellular
    • activities
  • 60. Formation & Usage of ATP
    • Hydrolysis of ATP (removal of terminal phosphate group by enzyme -- ATPase)
      • releases energy
      • leaves ADP (adenosine diphosphate)
    • Synthesis of ATP
      • enzyme ATP synthase catalyzes the addition of the terminal phosphate group to ADP
      • energy from 1 glucose molecule is used during both anaerobic and aerobic respiration to create 36 to 38 molecules of ATP
  • 61. End of Chapter 2
    • Copyright 2009 John Wiley & Sons, Inc. All rights reserved. Reproduction or translation of this work beyond that permitted in section 117 of the 1976 United States Copyright Act without express permission of the copyright owner is unlawful. Request for further information should be addressed to the Permission Department, John Wiley & Sons, Inc. The purchaser may make back-up copies for his/her own use only and not for distribution or resale. The Publishers assumes no responsibility for errors, omissions, or damages caused by the use of theses programs or from the use of the information herein.