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The work is carried on the application of differential equation (DE) and its computational technique of genetic algorithm and neural (GANN) in C#, which is frequently used in globalised world by human wings. Diagrammatical and flow chart presentation is the major concerned for easy undertaking of these two concepts with indication of its present and future application is the new initiative taken in this paper along with computational approaches in C#. Little observation has been also pointed during working, functioning and development process of above algorithm in C# under given boundary value condition of DE for genetic and neural. Operations of fitness function and Genetic operations were completed for behavioural transmission of chromosome.