Neurotransmitters and its  mechanism of action                    Presented by                   R.Parthasarathy
INTRODUCTION:What is neurotransmitterCriteriaGeneral characteristics featuresClassification   biochemical             ...
ANATOMY OF NERVE:        Postsynaptic:        Muscle  Contraction        Neuron  Action potential        Glands  Secret...
DEFINITION:Neurotransmitters are thechemical substanceswhich are responsible fortransmission of an impulse through asynaps...
CRETIA:                         50 substance are there Synthesized by pre-synaptic neurons with the help  of synthesizing...
Neuromediators or neurohormones:Neuromodulators:                   Neuromodulators:                   Eg: VIP,somatostatin...
ACTION OF NEUROTRANSMITTERS             general characteristicsNeurotransmitter travels pre  post synapticReceptors ass...
CLASSIFICATION:   BIOCHEMICALLY
PYSIOLOGICALLYEXCITATORY          INHIBITORYEg:Acetylcholine     GABA  Aspartate          Glycine  Dopamine  Histamine  No...
Excitatory neurotransmitters:
Inhibitory neurotransmitters:
Acetycholine:SYNTHESIS:•   Vasodilation,•   cardiac inhibition,•   GI peristalsis;•   control of thought, mood, sleep, mus...
SYNTESIS      Catecholamines:Dopamine:  Control of movements(parkinsonism)  Induction of vomiting  Inhibition of prolactin...
Serotonin:SYNTHESIS:FUNCTIONS:Regulation    Carbohydrate intake &    Hypthalamic releasing hormonePain inhibitionHallucina...
Histamine:SYNTHESIS:
Amino acid:SYNTHESIS:
OVERVIEW.
Neuropeptide transmitters:
General mechanism of action
Acetylcholine esterase
Thank you
Neurotransmitters and its mechanism of action
Neurotransmitters and its mechanism of action
Neurotransmitters and its mechanism of action
Neurotransmitters and its mechanism of action
Neurotransmitters and its mechanism of action
Neurotransmitters and its mechanism of action
Neurotransmitters and its mechanism of action
Neurotransmitters and its mechanism of action
Neurotransmitters and its mechanism of action
Neurotransmitters and its mechanism of action
Neurotransmitters and its mechanism of action
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Neurotransmitters and its mechanism of action

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Neurotransmitters and its mechanism of action

  1. 1. Neurotransmitters and its mechanism of action Presented by R.Parthasarathy
  2. 2. INTRODUCTION:What is neurotransmitterCriteriaGeneral characteristics featuresClassification biochemical physiologicalMechanism of action of individual chemical
  3. 3. ANATOMY OF NERVE: Postsynaptic: Muscle  Contraction Neuron  Action potential Glands  Secretion
  4. 4. DEFINITION:Neurotransmitters are thechemical substanceswhich are responsible fortransmission of an impulse through asynapse. Schematic diagram of synapse
  5. 5. CRETIA: 50 substance are there Synthesized by pre-synaptic neurons with the help of synthesizing enzyme and stored in vesicles at axon terminal. Stimulation of nerve cause release of transmitters. Travels between pre to post-synpatic membrane. Associated with an enzyme system(inactivation). Mimic the effects of nerve stimulation outside. Drugs which modifies nerve stimulation also modifies transmitter action the similar way.
  6. 6. Neuromediators or neurohormones:Neuromodulators: Neuromodulators: Eg: VIP,somatostatin,ckk,substance P etc
  7. 7. ACTION OF NEUROTRANSMITTERS general characteristicsNeurotransmitter travels pre  post synapticReceptors associated with Ion channels and enzyme(second messenger)Acts in millisecondsActivate both pre and post synaptic receptors.More transmitter interact both pre and post synaptically (Sp Rec & sp effects)
  8. 8. CLASSIFICATION: BIOCHEMICALLY
  9. 9. PYSIOLOGICALLYEXCITATORY INHIBITORYEg:Acetylcholine GABA Aspartate Glycine Dopamine Histamine Norepinephrine Epinephrine Glutamate Serotonin
  10. 10. Excitatory neurotransmitters:
  11. 11. Inhibitory neurotransmitters:
  12. 12. Acetycholine:SYNTHESIS:• Vasodilation,• cardiac inhibition,• GI peristalsis;• control of thought, mood, sleep, muscles, bladder, sweat glands
  13. 13. SYNTESIS Catecholamines:Dopamine: Control of movements(parkinsonism) Induction of vomiting Inhibition of prolactin secretion Stimulation of GnRH Schizophrenia
  14. 14. Serotonin:SYNTHESIS:FUNCTIONS:Regulation Carbohydrate intake & Hypthalamic releasing hormonePain inhibitionHallucinations and 5HTDepression of mood
  15. 15. Histamine:SYNTHESIS:
  16. 16. Amino acid:SYNTHESIS:
  17. 17. OVERVIEW.
  18. 18. Neuropeptide transmitters:
  19. 19. General mechanism of action
  20. 20. Acetylcholine esterase
  21. 21. Thank you

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