Osteoporosis

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Osteoporosis

  1. 1. OSTEOPOROSIS
  2. 2. CLINICAL MANIFESTATIONS • FRAGILITY FRACTURES. • COMPRESSION FRACTURE. • RADICULOPATHIC PAIN. • SPINAL CORD COMPRESSION OR CAUDA EQUINA SYNDROME.
  3. 3. STOOPED POSTURE KYPHOSIS
  4. 4. • INCREASED RISK FOR FALLING ASSOCIATED WITH AGING. • IMPAIRED BREATHING.
  5. 5. DIAGNOSIS
  6. 6. MANAGEMENT 1. • • • • • • LIFE STYLE CHANGES Dietary intake of adequate calcium and vit. D. Weight bearing. Harmone replacement therapy. Cigarette and alcohol cessation. Protein supplementation. Exposure to sunlight.
  7. 7. 2. EXERCISE
  8. 8. 3. MEDICATIONS • ANTIRESORPTIVE AGENTS Bisphosphonates Estrogen analogs Raloxifene Calcitonin • BONE ANABOLIC AGENTS Fluorides Teripartide Vitamin D supplement Calcium Salts
  9. 9. OSTEOMALACIA
  10. 10. PATHOPHYSIOLOGY INADEQUATE Ca++ & VIT D IN DIET INCREASED URINARY EXCRETION OF Ca++ LOSS OF Ca++ & PHOSPHOROUS DURING PREGNANCY AND LACTATION INADEQUATE CONCENTRATION OF CALCIUM OR PHOSPHORUS IN THE BODY DECALCIFICATION OF THE BONES SOFTENING OF THE BONES
  11. 11. DIAGNOSTIC EVALUATION • DECREASED SERUM CALCIUM LEVEL. • DECREASED SERUM POTASSIUM LEVEL. • INCREASED SERUM ALKALINE PHOSPHATASE LEVEL. • DECREASED URINARY CALCIUM. • X-RAY: PSEUDO-FRACTURES (MILKMAN’S SYNDROME). • BONE BIOPSY: DEMONSTRATE AN EXCESS OF OSTEOID.

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