Depression: shows physical & emotional depression-tx with Benzodiazepines or Phenothiazines
Heart disease : seizures, fatal cardiac
arrhythmias-tx IV diazepam
incidence of MI
It similar like cocaine
Elevation of catecholamine transmitters in synaptic spaces- releases intracellular stores of catecholamines
Blocks MAO, high level of catecholamines are readily released into synaptic spaces
CNS : incresed alertness, decreased fatigue, depressed appetite, insomnia, convulsions. These CNS stimulant effects of amphetamine & its derivatives have led to their use in the therapy of depression, hyperactivity in children , narcolepsy, appetite control
SNS : indirectly stimulating receptors through NE release
Attention deficit syndrome- tx Methylphenidate
Central effects : irritability, hyperactive reflexes, delirium, panic states, sucidal tendencies, amphetamine psychosis, overdose can be treated with Chlorpromazine
I/V administration with rapid development of tolerance, psychological and physical dependence.
oral administration milder effects.
overdoses leads to respiratory depression
potential for abuse, increased muscle mass & strength rather than euphoria. Excessive use behavioral, cvs and musculoskeletal effects, acne, antiandrogenic effects produced. Hepatic dysfunction and increased risk of MI. withdrawal symptoms associated with fatigue and depression of mood