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Pathology Seminar   October 2010 Year 4 MedicineGroup 1 UST Sana’a
Introduction                   DIC stands for Disseminated intravascular  coagulation. It is the disturbance of the blo...
Normal Hemostasis             During vascular injury hemostasis normally occurs  on the affected site. The hemostasis ha...
VASOCONSTRICTIONAfter vascular injury occurs there are certainfactors of neurohumoral type released causingtransient vasoc...
PRIMARY HEMOSTASISPlatelets adhere (via GpIb receptors) to exposedextracellular matrix by binding to von Willebrand factor...
SECONDARY HEMOSTASISLocal activation of the coagulation cascade (involvingtissue factor and platelet phospholipids) result...
TERTIARY HEMOSTASISCounter-regulatory mechanisms, such as release of t-PA (Tissue plasminogen activator, a fibrinolyticpro...
1)   Generation of a hyperthrombinemic state2)   Alteration of the physiological anticoagulants     levels3)   Impaired fi...
Generation of a  1)  hyperthrombinemic state                            The exposing of the tissue factors thromboplasti...
cont.: The   cascade goes here as follows                        
cont.: The   Thrombin in turn activates                      
Alteration of the physiological2)anticoagulants levels                                     There are 3 most common Antic...
cont.:   The cause of the decrease                       
Protein C function         Normally     In DIC
cont.:   Protein C’s Importance                      
Impaired fibrinolysis at the onset of3)the DIC:                                  Plasminogen activator inhibitor 1 (PAI-...
Activation and liberation of inflammatory4)cytokines                                      Activation of Clotting sys.  ...
Signs & symptoms of DIC                          Renal failure. Cough Confusion. Decreased platelets. Blood clots. ...
Sites of Thrombosis               Site in decreasing     order of frequency     Brain     Heart     Kidney     Adrenals  ...
DIC Is most likely to occur after sepsis, obstetric complications, malignancy, and major trauma        (especially trauma ...
Obstetric complications             Abruption placentae Retained dead fetus Septic abortion Amniotic fluid embolism ...
Infections                    Sepsis (gram negative and gram positive) Meningococcemia Rocky Mountain spotted fever H...
Neoplasms                  Carcinomas of pancreas, prostate, lung, and stomach Acute promyelocytic leukemia
Massive Tissue Injury             Trauma Burns Extensive surgery
Miscellaneous                 Acute intravascular hemolysis, Snakebite, Giant hemangioma Shock Heat stroke Vasculit...
1.   CBC2.   Clotting times:3.   Fibrin related markers important for the     diagnosis of DIC:4.   Coagulation factors:
Labinvestigations of DICCBCthrombocytopenia is usually presentClotting times:                                     Proth...
International Society onThrombosis and HaemostasisScoring System for Diagnosis ofDICA score below 5 issuggestive as adiagn...
1.   Underlying cause2.   Supportive therapy3.   Heparin therapy
Treatment                      The most important fact in the management of DIC, is the  treatment of the underlying cau...
DIC Presentation
DIC Presentation
DIC Presentation
DIC Presentation
DIC Presentation
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DIC Presentation

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A presentation about DIC (Disseminated Intravascular Coagulopathy).
Done by 4th year medical students at the University of Science and Technology, Sana'a, Republic of Yemen, in October 2010.

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  1. 1. Pathology Seminar October 2010 Year 4 MedicineGroup 1 UST Sana’a
  2. 2. Introduction  DIC stands for Disseminated intravascular coagulation. It is the disturbance of the blood clotting mechanism. Several clots in some vessels  increase consumption of the blood clotting factors and platelets deficiency, lack or destruction of those factors in other body parts Several bleedings in other areas of the body.
  3. 3. Normal Hemostasis  During vascular injury hemostasis normally occurs on the affected site. The hemostasis has four phases: 1. Vasoconstriction then, 2. Primary phase, 3. Secondary phase, 4. Tertiary phase,
  4. 4. VASOCONSTRICTIONAfter vascular injury occurs there are certainfactors of neurohumoral type released causingtransient vasoconstriction to the affected site.
  5. 5. PRIMARY HEMOSTASISPlatelets adhere (via GpIb receptors) to exposedextracellular matrix by binding to von Willebrand factorand are activated, undergoing a shape change and granulerelease. Released adenosine diphosphate and thromboxaneA2 lead to further platelet aggregation (via binding offibrinogen to platelet GpIIb-IIIa receptors), to form theprimary hemostatic plug.
  6. 6. SECONDARY HEMOSTASISLocal activation of the coagulation cascade (involvingtissue factor and platelet phospholipids) results infibrin polymerization, "cementing" the platelets into adefinitive secondary hemostatic plug.
  7. 7. TERTIARY HEMOSTASISCounter-regulatory mechanisms, such as release of t-PA (Tissue plasminogen activator, a fibrinolyticproduct) and thrombomodulin (interfering with thecoagulation cascade), limit the hemostatic process tothe site of injury.
  8. 8. 1) Generation of a hyperthrombinemic state2) Alteration of the physiological anticoagulants levels3) Impaired fibrinolysis at the onset of the DIC:4) Activation and liberation of inflammatory cytokines in the pathogenesis of DIC
  9. 9. Generation of a 1) hyperthrombinemic state  The exposing of the tissue factors thromboplastin and factor III during injury causes a cascade activation of a factor pathway that has a dominant role in the hyperthrombinemic state in DIC. Cytokines and bacterial endotoxin are all triggers to the formation of endothelial cell tissue factor. In severe trauma also tissue phospholipids initiates the clotting cascade.
  10. 10. cont.: The cascade goes here as follows 
  11. 11. cont.: The Thrombin in turn activates 
  12. 12. Alteration of the physiological2)anticoagulants levels   There are 3 most common Anticoagulants in the body:  Antithrombin,  Active Protein C  Tissue factor pathway inhibitor (TFPI).  In DIC:  ↓Antithrombin  ↓Active Protein C
  13. 13. cont.: The cause of the decrease 
  14. 14. Protein C function  Normally In DIC
  15. 15. cont.: Protein C’s Importance 
  16. 16. Impaired fibrinolysis at the onset of3)the DIC:   Plasminogen activator inhibitor 1 (PAI-1) is a neurohumoral compound released by the endothelial cells at the effected site.  PAI-1 suppresses the normal fibrinolysis activity.  Some DIC individuals have shown a mutation in the PAI-1 gene, leading to an increased plasma PAI-1 levels.
  17. 17. Activation and liberation of inflammatory4)cytokines   Activation of Clotting sys.  Inflammatory cascade activation Induced pro-inflammatory cytokines (thrombin and other serine proteases).  Pro-inflammatory cytokines + Protease-activated receptors (of the cell surface of the endothelial cells)  Inducing an inflammatory and clotting reaction.
  18. 18. Signs & symptoms of DIC  Renal failure. Cough Confusion. Decreased platelets. Blood clots. Drop in blood pressure. Sudden bruising. Bleeding, possibly from multiple sites in the body. Fever
  19. 19. Sites of Thrombosis  Site in decreasing order of frequency Brain Heart Kidney Adrenals Spleen Lungs Liver
  20. 20. DIC Is most likely to occur after sepsis, obstetric complications, malignancy, and major trauma (especially trauma to the brain)
  21. 21. Obstetric complications  Abruption placentae Retained dead fetus Septic abortion Amniotic fluid embolism Toxemia
  22. 22. Infections  Sepsis (gram negative and gram positive) Meningococcemia Rocky Mountain spotted fever Histoplasmosis Aspergillosis Malaria
  23. 23. Neoplasms  Carcinomas of pancreas, prostate, lung, and stomach Acute promyelocytic leukemia
  24. 24. Massive Tissue Injury  Trauma Burns Extensive surgery
  25. 25. Miscellaneous  Acute intravascular hemolysis, Snakebite, Giant hemangioma Shock Heat stroke Vasculitis Aortic aneurysm, Liver disease Rejection of graft
  26. 26. 1. CBC2. Clotting times:3. Fibrin related markers important for the diagnosis of DIC:4. Coagulation factors:
  27. 27. Labinvestigations of DICCBCthrombocytopenia is usually presentClotting times: Prothrombin time (PT) – prolonged (may be normal in early or chronic DIC)Partial thromboplastin time (PTT) – prolonged (may be normal in early orchronic DIC)Thrombin time (TT) – may be increased due to consumption of fibrinogenFibrin related markers important for the diagnosis of DIC:D-dimer – increased in acute and chronic DIC (best single test)A normal d-dimer essentially rules out DICElevated d-dimer levels are seen in a number of conditions in addition to DIC(eg, pregnancy, acute thrombosis)Coagulation factors:Fibrinogen is usually decreased (in an acute phase of DIC, the fibrinogen may notbe decreased, only until DIC is severe)
  28. 28. International Society onThrombosis and HaemostasisScoring System for Diagnosis ofDICA score below 5 issuggestive as adiagnosis but notdefinite; hence thetest must berepeated.
  29. 29. 1. Underlying cause2. Supportive therapy3. Heparin therapy
  30. 30. Treatment  The most important fact in the management of DIC, is the treatment of the underlying cause. Supportive therapy may be given to patients with excessive bleeding: 1) Fluid 2) Blood transfusion 3) Fresh frozen plasma 4) Platelet concentrates 5) Fibrinogen Patients with chronic DIC and thrombosis may need heparin therapy.
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