Dr fahad anti arrythmic drugs

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Dr fahad anti arrythmic drugs

  1. 1. Antiarrhythmic Drugs-Overview Dr. Fahad Azam Shifa College of Medicine
  2. 2. Classification of antiarrhythmic drugs Classification of drugs Mechanism of action IA Na+ channel blocker Qunidine, Procainamide IB Na+ channel blocker Lidocaine, Mexiletine IC Na+ channel blocker Flecainide, Propafenone II Beta receptor blocker Propanalol, Metoprolol III K+ channel blocker Amiodarone, Sotalol, IV Ca+ channel blocker Verapamil, Diltiazem, Nifedipine
  3. 3. Conduction Pathways and Velocity of Conduction• Conduction Pathway: SA node  atrial muscle  AV node  Purkinjee fibers  Ven. Muscle delay• Velocity: – Fast conducting fiber: • Purkinjee cell, Ventricular muscle, Atrial muscle – Slow conducting fiber: • AV node, SA node
  4. 4. Classification Mechanism of actionof drugsIA Na+ channel blocker Qunidine, ProcainamideIB Na+ channel blocker Lidocaine, MexiletineIC Na+ channel blocker Flecainide, PropafenoneII Beta receptor blocker Propanalol, MetoprololIII K+ channel blocker Amiodarone, Sotalol,IV Ca+ channel blocker Verapamil, Diltiazem, Nifedipine
  5. 5. Intracellular Extracellular Na Leak Na Pump K PumpK Diffusion

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