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Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
Pain Management (General concepts and primary discussions)
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Pain Management (General concepts and primary discussions)

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"Pain Management in Chronic Wound" workshop for nurses

"Pain Management in Chronic Wound" workshop for nurses

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  • Immune: Depressed immune response
    Developmental: behavioral, physiological responses to pain, higher somatization, addictive behavior, anxiety
    Cognitive: Reduction in mental function, confusion
    Future Pain: Debilitating chronic pain syndromes
    Quality of life: Insomnia, anxiety, fear, hopelessness, depression
    Endocrine: ACTH, cortisol, ADH, epinephrine, norepinepherine, GH, catacholamines, rennin, angiotensin II, aldosterone; ↓ insulin, testosterone
    Metabolic: Increased catabolic demands; poor wound healing, weakness, muscle breakdown, hyperglycemia
    Musculoskeletal: Muscle spasm, fatigue, immobility
    Cardiovascular: heart rate, cardiac output, increased coronary/peripheral/systemic vascular resistance, hypertension
    Respiratory: ↓ Flows and volumes = atelectasis; ↓cough = sputum retention, infection
    Gastrointestinal: ↓ gastric and bowel motility
    Genitourinary: ↓ urine output, urinary retention
  • Acute: treatment outcome predictable. Resolves in days to weeks.
    Chronic: treatment outcome unpredictable
  • Craven & Hirnle, 2003, p. 1173.
    Mechanical, chemical, or thermal events that injure tissue usually stimulate nociceptors.
    Injured cells and tissue-repair mechanisms release one or more chemical substances that bind to peripheral nociceptors and activate the nerve fiber, whereas others sensitize the nerve for activation with a smaller stimulus than usually required.
    These chemicals cause A-delta and C-fibers to become excited and transmit an action potential toward the spinal cord.
    Presence of these chemicals increases the amount of pain a person perceives.
    Blocking release or production of these chemicals is one peripheral mechanism to inhibit pain perception.
    Another way to inhibit pain is by blocking sodium channels on the A-delta or C-fibers (such as through the use of local anesthetic agents), thus preventing transmission of the action potential to the spinal cord.
  • http://www.intelihealth.com/IH/ihtIH/WSIHW000/29721/32087.html for more information on pain scales
    The Purpose Of Pain Scales
    These easy-to-use tools offer valuable insight into the experience of pain.
    By Rhonda B. GrahamInteliHealth Staff Writer retrieved on February 13th, 2007 from
    http://www.intelihealth.com/IH/ihtIH/WSIHW000/29721/32087.html#wong
    Pain scales are tools that can help your doctor diagnose or measure your pain's intensity. In some cases, the information provided can help your doctor choose the best treatment. The most widely used scales are visual, verbal, numerical or some combination of all three forms.
    Visual. Visual scales have pictures of human anatomy to help you explain where your pain is located. A popular visual scale — the Wong-Baker Faces Pain Rating Scale — features facial expressions to help you show your doctor how the pain makes you feel. This scale is particularly useful for children, who sometimes don't have the vocabulary to explain how they feel.Verbal. Verbal scales contain commonly used words such as "low," "mild" or "excruciating" to help you describe the intensity or severity of your discomfort. Verbal scales are useful because the terminology is relative, and you must focus on the most characteristic quality of your pain.Numerical. Numerical scales help you to quantify your pain using numbers, sometimes in combination with words.
    To be most accurate, pain scales are best used as the pain is occurring. Over time, with treatment, your doctor can use pain scales to record how your pain is changing and to see if treatment is having the intended effect. If you suffer from chronic pain, print out one of the scales provided to help you describe or rate your discomfort for your doctor. Ask your doctor if he or she prefers one of these pain scales or a different one.The Wong-Baker Faces Pain Rating Scale
    Designed for children aged 3 years and older, the Wong-Baker Faces Pain Rating Scale is also helpful for elderly patients who may be cognitively impaired. If offers a visual description for those who don't have the verbal skills to explain how their symptoms make them feel.
    From Wong D.L., Hockenberry-Eaton M., Wilson D., Winkelstein M.L., Schwartz P.: Wong's Essentials of Paediatric Nursing, ed. 6, St. Louis, 2001, p. 1301. Copyrighted by Mosby, Inc. Reprinted by permission.
    To use this scale, your doctor should explain that each face shows how a person in pain is feeling. That is, a person may feel happy because he or she has no pain (hurt), or a person may feel sad because he or she has some or a lot of pain.
    Face 0 is very happy because he or she doesn't hurt at all.
    Face 1 hurts just a little bit.
    Face 2 hurts a little more.
    Face 3 hurts even more.
    Face 4 hurts a whole lot.
    Face 5 hurts as much as you can imagine, although you don't have to be crying to feel this bad.
    You should point to each face using the words to describe the pain intensity. You should then choose the face that best describes how you feel.
    A Verbal Pain Scale
    With a verbal scale, you can describe the degree of your discomfort by choosing one of the vertical lines that most corresponds to the intensity of pain you are feeling. This is a good way to explain early postoperative pain, which is expected to diminish over time. Your doctor can use this scale to determine if your recovery is progressing in a positive direction.
    A Numerical Pain Scale
    A numerical pain scale allows you to describe the intensity of your discomfort in numbers ranging from 0 to 10 (or greater, depending on the scale). Rating the intensity of sensation is one way of helping your doctor determine treatment.
    From Margo McCaffery, RN,MS, FAAN and Chris Pasero, RN MSNc: Pain Clinical Manual, 2nd Edition, 1999, p. 63. Copyrighted by Mosby, Inc. Reprinted by permission.
    Numerical pain scales may include words or descriptions to better label your symptoms, from feeling no pain to experiencing excruciating pain. Some researchers believe that this type of combination scale may be most sensitive to gender and ethnic differences in describing pain.
    Last updated December 06, 2006
           
  • http://www.partnersagainstpain.com/index-mp.aspx?sid=3&aid=7692
    http://painconsortium.nih.gov/pain_scales/index.html
    Hicks CL, von Baeyer CL, Spafford P, van Korlaar I, Goodenough B. The Faces Pain Scale – Revised: Toward a common metric in pediatric pain measurement. Pain 2001;93:173-183.
    Scale adapted from: Bieri D, Reeve R, Champion GD, Addicoat L, Ziegler J. The Faces Pain Scale for the self-assessment of the severity of pain experienced by children: Development, initial
    validation and preliminary investigation for ratio scale properties. Pain 1990;41:139-150.
    From the Pediatric Pain Sourcebook. Original copyright © 2001. Used with permission of the International Association for the Study of Pain and the Pain Research Unit, Sydney Children’s
    Hospital, Randwick NSW 2031, Australia. This material may be photocopied for clinical use. For all other purposes permission should be sought from the Pain Research Unit: contact Tiina
    Piira, piirat@sesahs.nsw.gov.au Version: 24 Sep 2001
  • http://www.intelihealth.com/IH/ihtIH/WSIHW000/29721/32087.html
    Graham, B. R. B. (2006, December 6). The purpose of pain scales. Retrieved Feb 27, 2007
    Visual. Visual scales have pictures of human anatomy to help you explain where your pain is located. A popular visual scale — the Wong-Baker Faces Pain Rating Scale — features facial expressions to help you show your doctor how the pain makes you feel. This scale is particularly useful for children, who sometimes don't have the vocabulary to explain how they feel.
    Verbal. Verbal scales contain commonly used words such as "low," "mild" or "excruciating" to help you describe the intensity or severity of your discomfort. Verbal scales are useful because the terminology is relative, and you must focus on the most characteristic quality of your pain.
    Numerical. Numerical scales help you to quantify your pain using numbers, sometimes in combination with words.
    To be most accurate, pain scales are best used as the pain is occurring. Over time, with treatment, your doctor can use pain scales to record how your pain is changing and to see if treatment is having the intended effect.
    If you suffer from chronic pain, print out one of the scales provided to help you describe or rate your discomfort for your doctor. Ask your doctor if he or she prefers one of these pain scales or a different one.
  • Alexander, L. L. (2006). Pain management, palliative care and treatment of the terminally ill
    Step 1: nonopioid analgesics with or without coanalgesic agent for mild pain (1-3) on pain 10-point scale
    Step 2: for 4-6 on 1-10 scale, low dose opioid used in combination with a nonopioid analgesic for unrelieved pain.
    Step 3: severe pain 7-10 on 1-10 scale. Opioids are used. At any step, nonopioids and/or opioids may be helpful.
    Non-Opioid Drugs These are particularly suitable for pain in musculoskeletal conditions. Many are available over the counter for patients to buy. Examples: Paracetamol 500mg (0.5-1g every 4-6 hours, max 4g daily) Aspirin 300mg (300-900mg every 4-6 hours, max 4g daily)
    Non-steroidal anti-inflammatory drugs (NSAIDS) These drugs are very useful in the management of chronic diseases which are associated with pain and inflammation. They are also suitable to treat back pain, dysmenorrhoea and pain related to bone metastases in control of cancer pain.
    The main differences between the different NSAIDs available are in their incidence of side-effects. The commonest side-effects are gastro-intestinal. Azapropazone is associated with the highest risk and ibuprofen with the lowest, according to the CSM. They should be used with caution in the elderly and are contra-indicated in patients with a history of hypersensitivity to aspirin or any other NSAID. Examples: Ibuprofen 400mg (1.2-2.4g daily in 3-4 divided doses, max 2.4g daily) Diclofenac 75mg (75-150mg daily in 2-3 divided doses, max 150mg daily)
    Topical NSAIDs can also be used, with variable effect. One study indicated that topical non-steroidals are significantly more effective than placebo for pain relief 2.
    Cyclo-oxygenase 2 selective inhibitors These are similar in effect to diclofenac; however their risk of serious gastro-intestinal events is lower. NICE has recommended that they should only be used when clearly indicated for patients at high risk of developing serious gastro-intestinal side effects (eg age > 65 years). Examples: Celecoxib 100mg (200mg daily in 1-2 divided doses, max 200mg daily) Rofecoxib 12.5mg (12.5mg-25mg daily, max 25mg daily)
    Opioid Analgesics These are used to relieve moderate to severe pain, both for malignant and non-malignant conditions. Repeated administration may cause dependence and tolerance; however a review of retrospective and survey data confirms the efficacy of opioids in the treatment of chronic non-cancer pain and found that fears of addiction were not justified 3.
    The most common side effects include nausea, vomiting, constipation and drowsiness. They are available to given via the oral, transdermal, sublingual, rectal, subcutaneous, intramuscular and intravenous routes. Patients with chronic non-cancer pain generally preferred treatment with transdermal fentanyl (65%) than with sustained release oral morphine (28%)4.
    The dose of opioids is usually adjusted individually for patients as their response to opioids often varies tremendously. Examples: Oramorph 10mg/5ml 10mg as needed Codeine phosphate 30-60mg every 4 hours, max 240mg daily Morphine Sulphate - dose to be titrated with pain, given twice daily Fentanyl patches - 25mcg/hour upwards, depending on pain. Each patch lasts for 72 hours. Tramadol 50-100mg 4-6 hourly, max 400mg daily
  • Alexander, L. L. (2006). Pain management, palliative care and treatment of the terminally ill
    First three are best done with the WHO analgesic ladder which designates the type of analgesic based on the severity of pain.
  • Alexander, L. L. (2006). Pain management, palliative care and treatment of the terminally ill
    Primary contributor to delirium is unrelieved pain.
  • Transcript

    • 1. Pain Medicine Saeid Safari, MD Anesthesiologist, Iran University of Medical Sciences
    • 2. Sir William Osler, the eminent 19th-century clinician
    • 3. What is the Pain?
    • 4. Medical Definition: “Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage.” International Association for the Study of Pain, 1979 “An unpleasant sensation induced by noxious stimuli and generally received by specialized nerve endings.” CancerWEB, 2011
    • 5. Operative Definition: “Pain is whatever the experiencing person says it is, existing whenever he/she says it does.” Margo McCaffery, 1999
    • 6. Epidemiology
    • 7. Epidemiology • 50 million people are partially or totally disabled due to pain • 70 to 90% of patients with advanced disease from cancer have significant pain that requires the use of opioid drugs. • Severe, unrelenting pain interferes with patients' quality of life, including their activities of daily living, their sleep, and their social interactions.
    • 8. Epidemiology • 80% of elderly patients have chronic pain. • 66% have pain in the last month of life • ~ ½ of hospitalized patients with pain are under-medicated. • Up to 50% of patients who are taking pain medication do not experience adequate relief
    • 9. Economics • Chronic pain causes 700 million lost work days/year in the U.S. • > $ 9 billion per year on OTC pain products. • Estimated cost of pain is $150 billion per year
    • 10. Physiologic Effects of Pain • Immune System • Developmental • Future Pain • Quality of Life • Endocrine & Metabolic • Musculoskeletal • Cardiovascular • GI/GU
    • 11. Psychiatric Disorders in Chronic Pain
    • 12. • Chronic pain is often comorbid with psychiatric disorders. • The typical finding is an increased occurrence of psychiatric disorders among persons with a specific pain condition when compared with persons with no pain. • Depression is the most commonly studied psychiatric disorder in the context of chronic pain.
    • 13. • A higher occurrence of major depressive disorder among persons with chronic pain. • The association of pain with anxiety disorders • A higher level of disability is often associated with comorbid depression and anxiety disorders
    • 14. • Other than depression and anxiety, somatoform disorders, substance use disorders, and personality disorders have all been found to be more common among patients with chronic pain compared with those without chronic pain • Posttraumatic stress disorder (PTSD) has received particular attention in the literature.
    • 15. Pain Behaviors
    • 16. Reactions to Pain 1. Somatic Motor Reactions 2. Autonomic Reactions 3. Emotional and Psychogenic Reactions 4. Hyperalgesia
    • 17. 1) Somatic Motor Reactions • Excess neuromuscular excitability throughout the body. • Withdrawal Reflexes. • Immobilization Reaction. • Guarding Reaction.
    • 18. 2) Autonomic Reactions • Mild Cutaneous pain • a pressor reaction = rise of blood pressure and heart rate, mediated by sympathetic stimulation. • Sever cutaneous, deep and visceral pain • a depressor reaction associated with hypotension, bradycardia, and nausea, due to parasympathetic stimulation. • Such pain is often described as sickening pain and may be accompanied by vomiting.
    • 19. Autonomic Response to Pain • Grimacing • Restlessness • Guarding • Increased respirations • Increased heart rate • Increased blood pressure • Diaphoresis
    • 20. 3) Emotional and Psychogenic Reactions • Anxiety, fear, crying, depression, as well as the feeling of being hurt may be felt by the pained person. • These reactions vary: - From person to person on exposure to similar pain stimuli - in the same person according to his emotional state
    • 21. 3) Emotional and Psychogenic Reactions 1. Worry about the cause of pain augment the feeling of pain. • Thus, Patients suffer than healthy subject to the same degree of pain. 2. Strong emotional excitement & sever physical exertion may block the feeling of pain. • Thus, seriously wounded soldiers in a battlefield suffer little or no pain till the battle is over.
    • 22. Four Types of Pain Behaviors • Facial/audible expression of distress • Distorted ambulation or posture • Negative affect • Avoidance of activity
    • 23. Emotions, Coping, and Pain • Higher levels of 1. 2. Anxiety and Stress, 3. Fear, 4. Sadness, 5. • Depression Anger Fewer observable outward physical changes/signs.
    • 24. 4) Cutaneous Hyperalgesia Increased skin sensitivity to pain. 1- Primary Hyperalgesia 2- Secondary Hyperalgesia - Develop 30-60 min. after injury. Develops later. - Lasts for several hours or days. - Shorter duration than 1ry. - In the area of redness. - Non-painful stimuli (as touch) becomes painful. - In healthy skin surrounding red area. - Pain is felt more sever than normal. Mechanism: Central sensitization explained by Decreased pain threshold due to local convergence-facilitation theory. axon reflex releasing substance P
    • 25. Pain Terminology, Classifications, and Pathophysiology
    • 26. Definitions • An unpleasant sensory and emotional experience associated with actual or potential tissue damage and modified by individual memory, expectations and emotions. • Pain is whatever the experiencing person says it is. • Highly subjective, leading to under treatment
    • 27. Types of Pain 1. Acute (<6 months) 2. Chronic (6 months <)
    • 28. Acute pain: • lasts less than 6 months, subsides once the healing process is accomplished.
    • 29. Presentation of Pain Acute Chronic • • Often obvious distress • Can be sharp, dull, shock-like, tingling, shooting, radiation, fluctuating in intensity, and varying in location (occur in timely relationship to noxious stimuli) • • Comorbid conditions usually present Can appear to have noticeable suffering • Can be sharp, dull, shock-like, tingling, shooting, radiation, fluctuating in intensity, and varying in location (do NOT occur in timely relationship to noxious stimuli) • Symptoms may change over time • Usually NO obvious signs not May see HTN, increased HR, diaphoresis, pallor… no
    • 30. Acute Pain (Nociceptive) • Somatic • Superficial (nociceptors of skin) • Deep [body wall (muscle, bone)] • Visceral (sympathetic system; may refer to superficial structures of same spinal nerve)
    • 31. Acute Pain • Travels into the spinal cord along the appropriate nerve root. • Nerve root splits into a front division and a back division and carries pain sensation to the CNS (spinal cord and brain). • Passed to a short tract of nerve cells (interneurons), which in turn synapse with a nerve tract that runs to the brain .
    • 32. Acute Pain • Sent out to the rest of the brain, connecting with thinking and emotional centers. • A modifier pathway from the brain modifies pain at the synapses in the back part of the spinal cord (acute pain is decreased rapidly after tissue injury).
    • 33. Chronic pain: • Complex processes & pathology. • Usually altered anatomy & neural pathways. • Constant & prolonged, > 6 months, sometimes for life. • “Lasting longer than expected time frame”
    • 34. Altered Neural Structure • Chronic pain accompanied by: • Cortical Reorganization • Brain Atrophy
    • 35. Chronic Pain 1. Malignant (cancer) 2. Nonmalignant • Neuropathic (nerve injury) • Inflammatory (musculoskeletal) • Mixed or unspecified • Psychogenic
    • 36. Peripheral Nerve Fibers Involved in Pain Perception • A-delta fibers–small, myelinated fibers that transmit sharp pain • C-fibers–small unmyelinated nerve fibers that transmit dull or aching pain.
    • 37. Chronic Pain • Neuropathic: • Severe pain disorder that results from damage to the central and peripheral nervous systems. • Centrally generated • Peripherally generated • Inflammatory: • Results from the effects of inflammatory mediators.
    • 38. Chronic Pain Conditions • Neuralgia • an extremely painful condition consisting of recurrent episodes of intense shooting or stabbing pain along the course of the nerve. • Causalgia • recurrent episodes of severe burning pain. • Phantom limb pain • feelings of pain in a limb that is no longer there and has no functioning nerves.
    • 39. • Schematic of cortical areas involved with pain processing and fMRI
    • 40. Major Categories of Pain 1. Nociceptive pain (stimuli from somatic and visceral structures) 2. Neuropathic pain (stimuli abnormally processed by the nervous system)
    • 41. Nociceptive Pain • Visceral Pain: Associated with internal organs. • Nature: Crampy, pressure, deep, dull to sharp, diffuse, referred. • Somatic pain : Soft tissues/ myalgic. • Nature: Dull to sharp, throbbing, achy, localized
    • 42. Neuropathic Pain • Abnormal neural processing by the peripheral or central nervous system. • Signals are amplified or distorted; Synapse receptor numbers are altered; pathways not originally involved become involved • Patient Description of Neuropathic Pain: • Burning, electric, searing, tingling, and migrating or traveling.
    • 43. Tracking the Path of Pain • Peripheral receptors • Neural pathways • Spinal Cord mechanisms & long tracts • Brainstem, thalamus, cortex & other areas. • Descending pathways.
    • 44. Pain Gate Control 3 The sites of synapses along the pain pathway are considered as gates through which pain transmission can be facilitated (if the gate is open) or blocked (if the gate is closed). 2 The main pain gates are: 1- Spinal gate: at the SGR. 2- Brain stem gate: at the nuclei of reticular formation. 3- Thalamic gate: At neurons of PVLNT & intalaminar thalamic nuclei. 1
    • 45. Pain Pathways: 1. Painful Stimuli or tissue damage activate specialized nerve cells (nociceptors), which in turn send pain signals to the spinal cord. 2. Pain signals enter the dorsal horn of the spinal cord, where some are increased or decreased by the interneuron before continuing up to the brain. 3. Thoughts, feelings and beliefs change the pain signals into the individual’s experience of “PAIN". 4. Certain parts of the brain generate signals that travel back down the spinal cord to reduce or increase pain signals at the interneuron.
    • 46. Sites of Action Peripherally (at the nociceptor) Peripherally Local anesthetics, Medications Cannabinoids, NSAIDs, Opioids, Tramadol, Vanilloid receptor antagonists(i.e., capsaicin) Anticonvulsants (except the gabapentinoids) (along the nociceptive nerve) Centrally (various parts of the brain) Acetaminophen Anticonvulsants (except the gabapentinoids), Cannabinoids. Opioids, Tramadol Descending Inhibitory pathway in the spinal cord Cannabinoids, Opioids, Tramadol, Tricyclic antidepressants, SHRIs Dorsal horn of the spinal cord Anticonvulsants, Cannabinoids, Gabapentinoids, NMDA receptor antagonists, Opioids,. Tramadol, Tricyclic antidepressants, SNRIs
    • 47. Pain Assessment and Management
    • 48. Let’s try an experiment….  Have students take pen and place over nail bed and push. Describe sensation to neighbour. All the same?  Now try counting backwards from 10 while holding pressure on nail bed. Is the pain as bad?
    • 49. Patient Assessment • Assess and reassess • Use methods appropriate to cognitive status and context • Assess intensity, relief, mood, and side effects • Use verbal report whenever possible • Document in a visible place • Expect accountability • Include the family • Include past physician(s) • Get old records • Check for addictive personality
    • 50. Patient Pain History • Site(s) • What makes it better/worse • Quality • Impact on sleep, mood, • Severity • Date of onset • Duration activity • Effectiveness of previous medication
    • 51. PQRST mnemonic: • P: Precipitating and palliating factors • Q: Quality • R: Region and radiation • S: Severity • T: Time
    • 52. Instruments • Single-dimension • Visual analog scale • Verbal numerical scale • Verbal rating scale • Multidimensional • Assesses the pain as well as the emotional and behavioral effects of the pain.
    • 53. One type has faces—(Whaley & Wong, 198)
    • 54. Other pain scales are just numeric
    • 55. Single-dimension Instruments Verbal rating scale • No pain = 0 • Mild pain = 1-3 • Moderate pain = 4-6 • Severe pain = 7-9 • Worst ever = 10
    • 56. Can pain-intensity scales be used ? • Yes- but, limited by cognitive changes, impaired vision, physical limitation • no specific scale more “user friendly” • 83% of nursing home residents could complete a pain scale
    • 57. Why have a pain scale? • Sometimes hard to put words to pain • Pain is multi-faceted (How long? Where? How intense? What kind feeling? • Visual scales help us understand where pain located. • Faces help us understand how pain makes patient feel. • Numeric scales help quantify pain using numbers.
    • 58. Pain Management
    • 59. Pain Management Pharmacological & nonpharmacological management
    • 60. Principles of Treatment • Reduction of Pain: • Behavioral, Meds, Blocks, Surgery, Complementary • There is no magic bullet, no single cure • Rehabilitation: • Reconditioning & Prevention • Coping: • Management of Residual Pain
    • 61. Treatment Objectives • Decrease the frequency and / or severity of the pain • General sense of feeling better • Increased level of activity • Return to work • Decreased health care utilization • Elimination or reduction in medication usage
    • 62. Treatment of Pain 1. Non-pharmacologic 2. Medications • Nonsteroidal anti-inflammatory drugs (NSAIDs) • Acetaminophen • Antidepressants & anticonvulsants • Adjuvants • Narcotics 1. Invasive procedures Copyright © 2003 American Society of Anesthesiologists. All rights reserved
    • 63. Nonpharmacological Management
    • 64. Non-pharmacologic Pain Management • Neurostimulation • TENS • Acupuncture • Anesthesiology • Nerve block • Surgery • Physical therapy • Exercise • Heat/cold • Psychological approaches • Cognitive therapies (relaxation, imagery, hypnosis) • Biofeedback • Behavior therapy • Psychotherapy • Complementary tx • Massage therapy • Art therapy • Music therapy • Aroma therapy
    • 65. Non-Pharmacologic  Cognitive Behavioral Therapy: Yes, ‘A’, Cochrane “Cortical plasticity related to chronic pain can be modified by behavioral interventions that provide feedback to the brain areas that were altered by somatosensory pain memories.” H. Flor, 2002 & 03 “Individuals can gain voluntary control over … specific brain region… these effects were powerful enough to impact severe, chronic clinical pain.” de Charms, 2005, Nat’l Acad Sci
    • 66. Non-Pharmacologic  Meditation: Yes, ‘A’, Cochrane  Strong evidence for the use of relaxation & hypnosis in reducing pain in a variety of medical conditions  Music Therapy: Yes, ‘A’, Cochrane
    • 67. Non-Pharmacologic • Pre-Op counseling: Yes, ‘B’, Cochrane • Ice: Yes, “B”, Cochrane • Chiropractic: No, ‘B’, Cochrane • Massage: Yes for cancer, low back & OA pain, ‘B’, Cochrane • Exercise : Yes; ‘B’, Cochrane
    • 68. Non-Pharmacologic • Magnets: Don’t Know ‘I’, Cochrane • Spinal Cord Stimulation: Don’t know, ‘I’, Cochrane • Acupuncture: Don’t Know, ‘I’, Cochrane • TENS: Don’t Know, ‘I’, Cochrane
    • 69. Acupuncture • Acupuncture has been practiced in China for more than 4000 years as a method for pain relief. Mechanism: 1- needles in appropriate body regions are thought to excite certain sensory neural pathways which feed into the brain stem centers (such as the PAG) involved in the pain control system, with release of endogenous opioid peptides. 2- simultaneous suppression of pain transmission at the spinal pain-gate by acupuncture
    • 70. APA offers the following tips on coping with chronic pain: • Manage your stress. • Talk to yourself constructively. • Become active and engaged. • Find support. • Consult a professional.
    • 71. Manage your stress. • Emotional and physical pain are closely related, and persistent pain can lead to increased levels of stress. Learning how to deal with your stress in healthy ways can position you to cope more effectively with your chronic pain. Eating well, getting plenty of sleep and engaging in approved physical activity are all positive ways for you to handle your stress and pain.
    • 72. Talk to yourself constructively. • Positive thinking is a powerful tool. By focusing on the improvements you are making (i.e., the pain is less today than yesterday or you feel better than you did a week ago) you can make a difference in your perceived comfort level. For example, instead of considering yourself powerless and thinking that you absolutely cannot deal with the pain, remind yourself that you are uncomfortable, but that you are working toward finding a healthy way to deal with it and living a productive and fulfilling life.
    • 73. Become active and engaged. • Distracting yourself from your pain by engaging in activities you enjoy will help you highlight the positive aspects of your life. Isolating yourself from others fosters a negative attitude and may increase your perception of your pain. Consider finding a hobby or a pastime that makes you feel good and helps you connect with family, friends or other people via your local community groups or the Internet.
    • 74. Find support. • Going through the daily struggle of your pain can be extremely trying, especially if you’re doing it alone. Reach out to other people who are in your same position and who can share and understand your highs and lows. Search the internet or your local community for support groups, which can reduce your burden by helping you understand that you’re not alone.
    • 75. Consult a professional. • If you continue to feel overwhelmed by chronic pain at a level that keeps you from performing your daily routine, you may want to talk with a mental health professional, such as a psychologist, who can help you handle the physical and psychological repercussions of your condition.
    • 76. Using psychological factors in clinical practice
    • 77. Vigilance to pain • Patients are distorted by the pain and are urged to react. Pain patients will have impaired concentration as they are being interrupted constantly by an aversive stimulus. Keep all communications clear and brief. Repeat key points often. Expect patients to talk about the pain often, as it is being brought repeatedly into attentional focus for them. This is not a sign of a somatization disorder or hypochondria.
    • 78. Avoidance • Patients will naturally avoid pain and painful procedures. Be aware that this will occur and plan for it. Painful treatments will be avoided and patients will compensate for any disability caused by avoidance (e.g. shifted body weight distribution. ¡f a habitual pattern of avoidance develops, this may lead to chronic pain. Patients must be given an understanding that pain does not necessarily equal damage. A credible medical authority must deliver this message.
    • 79. Anger • Patients with pain may shout at you, abuse you and generally be hostile to you. If they are hostile to you they have probably been hostile to everyone. Most often this will have nothing to do with you. and you will need to understand that anger normally means extreme frustration, distress and possibly depression. Anger functions to push people away and isolate a person. The angry pain patient is therefore less likely to have received or heard any information about their problems and be more confused than the non-angry patient.
    • 80. Involve the patient • First, assess the patient’s normal way of coping with pain by simply asking how he or she has coped with predictable pain, such as a visit to the dentist. Secondly, match your strategy to the patient’s preference. ¡f the patient needs information, inform them how much pain they may expect to feel, what it may feel like and, critically, for how long (if this information is known). Always slightly overestimate the time rather than underestimate it. Finally, if possible. involve the patient in the delivery of any pain management strategy.
    • 81. Make sense of the pain • Always ask the patient what they know and fear about the cause of the pain, the meaning of the pain and the time course of the pain. Expect the unexpected. What makes sense to one person is nonsense to another. What matters is that it is their understanding, not yours, that will inform their behaviour. Uncertain diagnoses or unknown diagnoses will lead to increased vigilance to pain and increased symptom reporting.
    • 82. Consistency • Develop a consistent approach to clinical information, patient instruction and patient involvement within pain management. Practice should be consistent for each patient and from each member of the pain team, over time.
    • 83. Pharmacological management:
    • 84. Using Pharmacological Options Safely • Pharmacokinetics • Pharmacodynamics • Compliance • Cost • Polypharmacy
    • 85. Modified WHO 3- Step Analgesic Ladder Quality of Life Proposed 4th Step Invasive treatments Pain Severity Opioid Delivery Pain persisting or increasing Step 3 Opioid for moderate to severe pain ± Nonopioid ± Adjuvant 8 -10 Pain persisting or increasing The WHO Ladder Step 2 Opioid for mild to moderate pain ± Nonopioid ± Adjuvant 4-7 Pain persisting or increasing Step 1 ± Nonopioid ± Adjuvant Pain Deer, et al., 1999 1-3
    • 86. • Step 1: non-opioid analgesics • (COX-2, Aspirin, Acetaminophen, Diclofenac, Ibuprofen, Tenoxicam, Panadeine, Nurofen. • Pain rating 1-2-3) Step 2: mild opioid is added (not substituted) to step 1 • (Codeine, Propoxyphene, Tramadol, Sevredol, DHC Continus, Dihydrocodeine tartate. • Pain rating: 4-5-6) Step 3: Opioid for moderate to severe pain is used and titrated to effect • Oxycodone, Morphine, Fentanyl, Pethidine, Ketamine Pain rating 7-10
    • 87. Remember basic principles: • Use WHO pain ladder • Take a careful drug history • Know the pharmacology of the Rx • “Start low, go slow” • Regularly review the regimen • Remember that drugs may cause illness
    • 88. Pharmacological management: • Selection of appropriate drug, dose, route and interval • Aggressive titration of drug dose • Prevention of pain and relief of breakthrough pain • Use of coanalgesic medications • Prevention and management of side effects
    • 89. Patient Controlled Analgesia (PCA)
    • 90. Pharmacology of Nociception Four Steps: 1. Transduction • NSAIDs, Local Anesthetics & Anticonvulsants 2. Transmission • Opioids, NMDA Antagonists 3. Perception • Distraction, Relaxation, Imagery 4. Modulation • Tricyclic Antidepressants, Opioids, GABA Agonists
    • 91. Manage side-effects opiates: • Constipation • Tolerance to nausea and sedation develops in 3-7 days. • Use adjuvant (coanalgesic) agents with opioid: • Tricyclic antidepressants • Corticosteroids • Anticonvulsants • Muscle relaxants • Stimulants
    • 92. Physical Dependence • A process of neuro-adaptation • Abrupt withdrawal may → abstinence syndrome • If dose reduction required, reduce by 25-50% q 2–3 days; avoid antagonists.
    • 93. Tolerance • Reduced effectiveness to a given dose over time. • If dose is increasing • suspect opioid tolerance • disease progression • psychological/spiritual pain
    • 94. Addiction • Acceleration of abuse patterns onto a primary illness. • Characteristics: • Psychological dependence • Compulsive use • Loss of control over amount and frequency of use • Loss of interest in pleasurable activities • Continued use of drugs in spite of harm
    • 95. Pseudoaddiction • Drug seeking behavior associated with a person’s need to relieve pain and suffering, not an obsession with the mood altering affects of medication. Wesson et al, 1993
    • 96. Chronic Pain Medical Issues • Physical Exam • History documenting prescribing rationale • Pain assessment documentation
    • 97. Legal Issues • Accurate prescription records • Controlled substance laws • Schedule • Emergency Telephone Prescriptions • Nursing Home Patients Fax prescriptions
    • 98. Skilled Prescribing • Patient –Physician Partnership • Pain management expectations • Medication responsibilities • One physician • One pharmacy
    • 99. Role of Invasive Procedures • Optimal pharmacologic management can achieve adequate pain control in 80-85% of patients • The need for more invasive modalities should be infrequent • When indicated, results may be gratifying
    • 100. Role of Invasive (“Anesthetic”) Procedures • Intractable pain* • Intractable side effects* *Symptoms that persists despite carefully individualized patient management
    • 101. What about the 20% who do not get relief from the WHO ladder • Has a true pain assessment been accomplished? • Have you examined the patient? • Is the pain neuropathic? • Is the patient receiving their medication? • Is the medication schedule and route appropriate? • Have the opioids been titrated aggressively? • Have invasive techniques been employed?
    • 102. What about the 20% who do not get relief from the WHO ladder • Lastly, • Cosider checking a vitamin D level : • There is an association between Vitamin D levels & chronic pain in women. • Women with levels of 75 – 99 nmol/L had less pain. • Ann Rheum Dis. August 12, 2008.
    • 103. Importance of Teamwork • Complex chronic pain, especially if caused by life-threatening disease, is best treated by a team. • The diverse talents of physician, nurse, social worker, chaplain, working together offers comprehensive control of physical, emotional, and spiritual pain. • Palliative care is for ALL patients who are suffering.
    • 104. So, what about “Pain Clinics” • Depends on where you live and of what they consist. • “Most” are not teams, but 1 or more anesthesiologists. • Most • Want to do invasive procedures • Prefer not to manage chronic medications • Do NOT have practitioners Psychologists nor alternative medical

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