SSDN SACHIN LPU GUIDE MR. NARENDRA PANDEY

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fast dispersible tablets,reprimelts,mouth dissolving tablets.

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  • excellent ppt
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  • Namaste sir, i have read your ppt , its so useful to me, i m doing m.pharm in pharmaceutics.my project is running also on ODT, plz send me this PPt as it is much helpful to me n also give me guidance.
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  • sir im very much impressed by ur presentation and wish to include some in ma seminar , so plz forward me the same to the email danish_kurien@yahoo.com, sir i will be very grateful. hope u will reply at the earliest, thanking u
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  • hiii frnd ur ppt is great abt mouth dissloving tablets ..can u plz send this ppt to my mail ID babuagoodboy@yahoo.com becoz my project is on mouth dissolving tablets so plz
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  • hello frndz....this is very nice ppt on ODT if u ve got ll u plz send it on axay.jarag@gmail.com
    thanking u.
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SSDN SACHIN LPU GUIDE MR. NARENDRA PANDEY

  1. 1. PREPARATION AND EVALUATION OF MOUTH DISSOLVING TABLET<br />Presented By: Under the guidance of:<br />Sachin Mr. NarendraPandey<br />
  2. 2. Contents<br />Literature Review<br />Introduction<br />Promising drug candidates for MDT<br />Popular Disintegrants used in MDT<br />Techniques for MDT formulation<br />Marketed Products of MDT <br />Evaluation<br />Future Planning<br />2<br />
  3. 3. Literature Review<br /><ul><li>Mahapatra A K, Murthy P N, Sahoo J, Biswal J, Sahoo S K Formulation design and optimization of mouth dissolving tablets of levocetirizine hydrochloride using sublimation technique. Indian J. Educ. Res. 2009; 43(1):39-45.
  4. 4. Shirsand S B, Suresh S, Para M S, Swamy P V, Kumar N D, Plantagoovata mucilage in the design of fast disintegrating tablets. Indian J. Pharm. Sci. 2009;41-46.
  5. 5. Gattani S. G, Shiyani B.G, KakadeK.N,Patil A.B, Surana S.J. Formulation and evaluation of mouth dissolving tablet of ondansetron hydrochloride by using superdisintegrants. Indian drugs. 2009; 46(1): 44-50.
  6. 6. Shoukri A R, Ahmed S I, Shamma N R. In vitro and in vivo evaluation of nimesulidelyohilized orally disintegrating tablets.Eur. J. Pharm. biopharm. 2009; 30: 1-10.
  7. 7. Goswami J P, Sharma S, Gupta G D. An effervescent and reproducible method for prepration of fast disintegrating tablets. Pharma Buzz. 2009; 4(3): 46-52.</li></ul>3<br />
  8. 8. Continued...<br /><ul><li>Kumar S R, Lakshmi S V P. Reprimelts: A novel approach in drug delivery systems. Pharma buzz. 2009; 4(5): 18-20
  9. 9. Shukla D, Chakraborty S, Singh S, Mishra B. Mouth dissolving tablets: An overview of Formuation technology. ScientiaPharmaceutica. 2009; 77: 309-326.
  10. 10. Fini A, Bergamante V, Ronchi C, Moraes F A C. Fast Dispersible/slow releasing ibuprofen tablets. Eur. J. Pharm. Biopharm. 2008; 69: 335-341.
  11. 11. Shah P P, Rajashree C M. Formulation and evaluation of primaquine phosphate taste- masked rapidly disintegrating tablet. J. Pharm. Pharmcol. 2008; 60: 1279-1285.
  12. 12. Rashid I, Remawi A M, Eftaiha A A,BadwanA.Chitin –Silicon Dioxide coprecipitate as a novel superdisintegrant. Indian J. Pharm. Sci. 2008; 97(11): 4955-4969.
  13. 13. Patel D M, Patel M M..Optimization of etorocoxib tablets prepared by sublimation technique. Indian J. Pharm. Sci. 2008; 70(1): 71-76.
  14. 14. Chaudhri P.D, Chaudhari S.P, Lanke S.D, Patel N. Formulation and in vitro evaluation of taste masked orodispersible dosage form of levocetirizinedihydrochloride. Indian J. Pharm. Edu. Res. 2007; 41(4): 319-327.</li></ul>4<br />
  15. 15. Continued...<br /><ul><li>Lakade S H, formulation development and evaluation of mouth dissolving tablets of ondansetron hydrochloride. Asian J. Pharm. 2007; 1(2-3): 150-153.
  16. 16. Qalaji R M M, Simons R E F, Simons J K. Fast-disintegrating sublingual epinephrine tablets: Effect of tablet dimension on tablet characteristics. Drug Dev. Ind. Pharm. 2007; 33: 523-530.
  17. 17. Shishu, AshimaB,Singh T. Preparation of tablets Rapidly disintegrates in the saliva containing bitter taste masked granules by compression method. Indian J. Pharm. Sci. 2007; 69(1):80-84.
  18. 18. Ciper M, Bodmeier R. Modified conventional hard gelatin capsules as fast disintegrating dosage form in the oral cavity. Eur. J. Pharm. biopharm. 2006; 62: 178-184.
  19. 19. Mizumoto T, Masuda Y, Yamamoto T, Yonemochi E, Terada K.formulation design of a novel fast-disintegrating tablet. Int. J. Pharm. 2005; 306: 83-90.
  20. 20. Valleri M, Mura P, Cirri M, Balllerini R. Development and evaluation of glyburide fast dissolving tablets using solid dispersion technique.Drug Dev. Ind. Pharm. 2004; 30(5): 525-534.</li></ul>5<br />
  21. 21. Introduction<br /><ul><li>MDTs are also called as orodispersible tablets, quick disintegrating tablets, fast disssolving tablets, porous tablets and reprimelts.
  22. 22. USP and EP used the term ODT for the tablets that disperses readily and within 3 minutes in mouth before swallowing.
  23. 23. US-FDA defined ODT as “A solid dosage form containing medicinal substances or active ingredient which disintegrates rapidly usually with in a matter of seconds when placed on the tongue.”</li></ul>Shukla et al., Mouth Dissolving Tablet: An overview of Evaluation Techniques. Sci. Pharm. 2009; 77: 309-326. <br />6<br />
  24. 24. Why MDT..??<br /><ul><li>Preferred route of administration
  25. 25. Improved patient compliance
  26. 26. Beneficial for travelling patients
  27. 27. Bypass First pass metabolism
  28. 28. Benefit of both liquid and solid dosage form</li></ul>Gopala et al., An Effective and Reproducible Method For Preparation Of Fast disintegrating tablet. Pharma Buzz. 2008; 3(9): 38-40<br />7<br />
  29. 29. Promising drug candidates for MDT<br />. <br />8<br />Sharma et. al. Mouth dissolving tablet : A Review. Pharma Buzz. 2009; 4(1): 30-41<br />
  30. 30. Continued...<br />9<br />
  31. 31. 10<br />Continued...<br />
  32. 32. Popular Disintegrants used in MDT<br />11<br />Sharma et al., Mouth dissolving tablet: A review.Pharma Buzz.2009; 4(01): 30-41.<br />
  33. 33. Continued...<br />12<br />
  34. 34. Mechanism of action of superdisintegrants<br />13<br />Sharma et al., Mouth dissolving tablet: A review.Pharma Buzz.2009; 4(01): 30-41.<br />
  35. 35. Techniques for MDT formulation<br />Lyophilisation<br />Moulding<br />Direct compression <br />Cotton candy process<br />Spray drying<br />Sublimation<br />Mass extrusion<br />Nanonization<br />Fast dissolving films<br />14<br />Shukla et al., Mouth Dissolving Tablet: An overview of formulation technology. Sci. Pharm. 2009; 77: 309-326. <br />
  36. 36. Sublimation technique for prepration of mdt<br />15<br />Sharma et al., Mouth dissolving tablet: A review.Pharma Buzz.2009; 4(01): 30-41.<br />
  37. 37. 16<br />List of Patented Technology Based Branded Products<br />Shukla et al., Mouth Dissolving Tablet: An overview of formulation technology. Sci. Pharm. 2009; 77: 309-326. <br />
  38. 38. 17<br />Continued...<br />
  39. 39. Marketed Products of MDT <br />Sharma et al., Mouth dissolving tablet: A review. Pharma Buzz.2009; 4(01): 30-41.<br />18<br />
  40. 40. EVALUATION<br />Granules:<br /><ul><li>Angle of repose
  41. 41. Bulk density
  42. 42. Tapped density
  43. 43. Powder flow properties</li></ul>Bhise et. al. Formulation and evaluation of fast disintegrating tablets of Diphenhydramine<br />tannate. 2006; 1(1): 41-45. <br />19<br />
  44. 44. EVALUATION OF TABLETS<br /><ul><li>Weight Variation
  45. 45. Hardness And Friability
  46. 46. Tensile Strength
  47. 47. Wetting time and water absorption Ratio
  48. 48. Friability
  49. 49. Disintegration test
  50. 50. Dissolution test</li></ul> Terada et. al. Evaluation of rapidly disintegrating tablets containing glycine and carboxymethylcellulose. Int. J. Pharm., 2006; 310: 101-109.<br />20<br />
  51. 51. in vitro dispersion test<br />21<br />Kumar S R, Lakshmi S V P. Reprimelts: A novel approach in drug delivery systems.Pharma buzz. 2009; 4(7): 72-76<br />
  52. 52. 22<br />Electroforce Disintegration Test Apparatus<br />Shukla et. al ,Mouth Dissolving Tablet: An overview Of Evaluation Techniques. Sci. Pharm. 2009; 77: 309-326. <br />
  53. 53. Disintegration test with rotary shaft method<br />23<br />Shukla et. al ,Mouth Dissolving Tablet: An overview Of Evaluation Techniques. Sci. Pharm. 2009; 77: 309-326. <br />
  54. 54. Modified Dissolution Test Apparatus For Disintegration Test<br />Shukla et al., Mouth Dissolving Tablet: An overview Of Evaluation Techniques. Sci. Pharm. 2009; 77: 309-326. <br />24<br />
  55. 55. how mdt dissolves<br />25<br />
  56. 56. Future Aspects <br /><ul><li>Search for the suitable and promising drug candidate.
  57. 57. Search for suitable and cheap superdisintegerant.
  58. 58. Select the feasible manufacturing technique
  59. 59. To make tablet which should disintegrate or dissolve in the mouth within a few seconds
  60. 60. To improve patient compliance
  61. 61. To allow high drug loading
  62. 62. To develop tablet with pleasing a mouth feel
  63. 63. To formulate MDT which will be compatible with taste masking and other excipients</li></ul>26<br />
  64. 64. Frequently asked questions<br /><ul><li>How mouth dissolving tablets are better than others?  </li></ul> Fast dissolving tablets are better than others because oral cavity has large blood supply, huge network of blood vessels. Mouth dissolving tablets get dissolved in the saliva and drug molecule get directly absorbed into blood stream after crossing thin epithellium of oral and tongue mucosa thus the drug acts fast, then normal oral route.<br /><ul><li>Is there is any need to take tablet with water?</li></ul> No, there is no need to take the tablet with water. As it gets dissolved in the saliva with in a few seconds<br /><ul><li>Will it be cost effective?</li></ul> Yes, simple technology and can be formulated with cheap excipients.<br /><ul><li>What is the real advantage of taking a Fast Melting Tablet?  </li></ul> It allows you to take the active ingredients and/or nutrients without swallowing the pill.<br />27<br />
  65. 65. 28<br />“If we knew what we were doing it wouldn&apos;t be RESEARCH…” ---Albert Einstein<br />

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