Restful Nights and Cheerful Days from Food Sourced Tryptophan
Tryptophan Isolated in 1901 Sir Frederick Hopkins
Tryptophan & Serotonin Tryptophan Step 1  + OH Step 2 -COOH Serotonin
Tryptophan Metabolism Is Light Dependent Tryptophan Serotonin Melatonin
Control Mechanisms in Melatonin Synthesis Pineal Gland <ul><li>Pineal Cells </li></ul><ul><li>Similar in structure to reti...
Julius Axelrod
Melatonin-Serotonin & Light Serotonin Superiour Cervical Ganglion Melatonin Supra Chiasmatic  Nucleus
Melatonin-Serotonin & Light Serotonin Superiour Cervical Ganglion Melatonin Supra Chiasmatic  Nucleus
5-HydroxyTryptophan 5-HTP Tryptophan Step 1  + OH Step 2 -COOH Serotonin
Tryptophan Usage/ 100,000 population (NEJM 1990) <ul><li>Prior to FDA ban 2% of American Households used tryptophan in a r...
Tryptophan Ban <ul><li>FDA based on cases of EMS </li></ul><ul><li>Before and after Showa Denka product </li></ul><ul><li>...
Tryptophan Available From Natural Sources But... <ul><li>Protein Sources Rich in Tryptophan  decrease   brain tryptophan l...
BBB  (Blood Brain Barrier)
Transport Sites
Transport Sites
Transport Sites (Sites occupied)
<ul><li>In fact a high protein meal increases blood levels of tryptophan but lowers brain levels </li></ul>Tryptophan  lev...
<ul><li>Carbohydrates prompt the pancreas to create insulin </li></ul><ul><li>Insulin reduces the blood level of all amino...
= Insulin
<ul><li>Carbohydrates reduce blood levels of all amino acids except for tryptophan </li></ul>
Finding the right protein
+ =
<ul><ul><li>Zenbev increases the serotonin level in the brain </li></ul></ul><ul><ul><li>With Zenbev, brain levels of tryp...
At night, serotonin  turns into melatonin Increase in serotonin  Melatonin  =
Sleep Study Nutritional Neuroscience Chronic Insomnia RestBites Tryptophan + Carbohydrate Carbohydrate
Protein Source Tryptophan versus Pharmaceutical Grade Tryptophan as an Efficacious Treatment for Chronic Insomnia
Anxiety Study Canadian Journal Of Physiology & Pharmacology Social Phobia RestBites Carbohydrate
Protein-source tryptophan as an efficacious treatment for  social anxiety disorder: a pilot study
Eat 1 chocolate ½ hour before bedtime. Try this for three nights and if required, increase by 1 chocolate until the desire...
Ingredients:   Partially Defatted Deoiled Organic Pumpkinseed Flour, Organic Agave Nectar, Sugar, Chocolate Coating, Caram...
FAQ’s <ul><li>What if I take Zenbev during the day, will I get sleepy? </li></ul><ul><li>Can’t I just eat some pumpkin see...
Amide Form Amine Form
Benefits <ul><li>Promotes Deep, Restful Sleep and Daytime Calm </li></ul><ul><li>No Hangover effect in the morning </li></...
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Hudson Zen Bev

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Hudson Zen Bev

  1. 1. Restful Nights and Cheerful Days from Food Sourced Tryptophan
  2. 2. Tryptophan Isolated in 1901 Sir Frederick Hopkins
  3. 3. Tryptophan & Serotonin Tryptophan Step 1 + OH Step 2 -COOH Serotonin
  4. 4. Tryptophan Metabolism Is Light Dependent Tryptophan Serotonin Melatonin
  5. 5. Control Mechanisms in Melatonin Synthesis Pineal Gland <ul><li>Pineal Cells </li></ul><ul><li>Similar in structure to retinal cells </li></ul><ul><li>Secrete melatonin at night </li></ul><ul><li>Secrete serotonin in the day </li></ul>
  6. 6. Julius Axelrod
  7. 7. Melatonin-Serotonin & Light Serotonin Superiour Cervical Ganglion Melatonin Supra Chiasmatic Nucleus
  8. 8. Melatonin-Serotonin & Light Serotonin Superiour Cervical Ganglion Melatonin Supra Chiasmatic Nucleus
  9. 9. 5-HydroxyTryptophan 5-HTP Tryptophan Step 1 + OH Step 2 -COOH Serotonin
  10. 10. Tryptophan Usage/ 100,000 population (NEJM 1990) <ul><li>Prior to FDA ban 2% of American Households used tryptophan in a regular basis </li></ul><ul><li>The sales growth curve was exponential </li></ul>
  11. 11. Tryptophan Ban <ul><li>FDA based on cases of EMS </li></ul><ul><li>Before and after Showa Denka product </li></ul><ul><li>Genetics play a role? </li></ul><ul><li>Contamination plays a role? </li></ul><ul><li>Most likely some combination of genetics & contamination </li></ul>
  12. 12. Tryptophan Available From Natural Sources But... <ul><li>Protein Sources Rich in Tryptophan decrease brain tryptophan levels. </li></ul>
  13. 13. BBB (Blood Brain Barrier)
  14. 14. Transport Sites
  15. 15. Transport Sites
  16. 16. Transport Sites (Sites occupied)
  17. 17. <ul><li>In fact a high protein meal increases blood levels of tryptophan but lowers brain levels </li></ul>Tryptophan level Serotonin level
  18. 18. <ul><li>Carbohydrates prompt the pancreas to create insulin </li></ul><ul><li>Insulin reduces the blood level of all amino acids except for tryptophan </li></ul><ul><li>Tryptophan levels rise relative to other amino acids </li></ul>Carbohydrate
  19. 19. = Insulin
  20. 20. <ul><li>Carbohydrates reduce blood levels of all amino acids except for tryptophan </li></ul>
  21. 21. Finding the right protein
  22. 22. + =
  23. 23. <ul><ul><li>Zenbev increases the serotonin level in the brain </li></ul></ul><ul><ul><li>With Zenbev, brain levels of tryptophan go up as blood levels go up </li></ul></ul>Zenbev Tryptophan = Anxiety level Serotonin level
  24. 24. At night, serotonin turns into melatonin Increase in serotonin Melatonin =
  25. 25. Sleep Study Nutritional Neuroscience Chronic Insomnia RestBites Tryptophan + Carbohydrate Carbohydrate
  26. 26. Protein Source Tryptophan versus Pharmaceutical Grade Tryptophan as an Efficacious Treatment for Chronic Insomnia
  27. 27. Anxiety Study Canadian Journal Of Physiology & Pharmacology Social Phobia RestBites Carbohydrate
  28. 28. Protein-source tryptophan as an efficacious treatment for social anxiety disorder: a pilot study
  29. 29. Eat 1 chocolate ½ hour before bedtime. Try this for three nights and if required, increase by 1 chocolate until the desired effect is achieved. <ul><li>90 calories per square </li></ul><ul><li>Low Fat (2.5 g) </li></ul><ul><li>0 Trans Fats </li></ul><ul><li>Caffeine Free </li></ul><ul><li>Low Sodium </li></ul>
  30. 30. Ingredients: Partially Defatted Deoiled Organic Pumpkinseed Flour, Organic Agave Nectar, Sugar, Chocolate Coating, Caramel, Sunflower Oil, Water, Agar, Soybean Oil, Soy Lecithin – Caffeine Free
  31. 31. FAQ’s <ul><li>What if I take Zenbev during the day, will I get sleepy? </li></ul><ul><li>Can’t I just eat some pumpkin seeds? </li></ul><ul><li>Why does this have Dextrose in it? </li></ul><ul><li>I took some Zenbev last night and I did not sleep any differently. Why? </li></ul><ul><li>What is the difference between this and l-tryptophan? </li></ul><ul><li>Is this different than the tryptophan that was banned a couple of years ago? </li></ul>
  32. 32. Amide Form Amine Form
  33. 33. Benefits <ul><li>Promotes Deep, Restful Sleep and Daytime Calm </li></ul><ul><li>No Hangover effect in the morning </li></ul><ul><li>Return to sleep easily after waking up in the night </li></ul><ul><li>No risk of dependence or tolerance </li></ul><ul><li>Replace Daytime Stress with a sense of calm control </li></ul><ul><li>Organic Ingredients </li></ul><ul><li>Clinically Proven effective </li></ul><ul><li>Patented product </li></ul>
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