The purpose of this review is to present an overview of various experimental models of chemically induced seizures. It is not intended to be an exhaustive review of all chemical models, but rather a “how to” description of some of the more popular models that have yielded important data concerning mechanisms of seizure propagation. This chapter will examine seizure models that are directly related to chemical or drug administration, and not, for example, those that may result from a chemical imbalance, such as produced by hypoxia or hypoglycemia. Finally, in vivo seizure models will be described. Important information can be derived from in vitro or slice studies, but these models are beyond the scope of this chapter.