4. Crystalloids Combination of water and electrolytes Balanced salt solution: electrolyte composition and osmolality similar to plasma; example: lactated Ringer’s, Plasmlyte, Normosol. - Hypotonic salt solution: electrolyte composition lower than that of plasma; example: D5W. True solution, No particulate Expands IVC adequately (less than colloids), however Small increase in plasma volume Replenishes interstitial compartment It leaves IVC faster ( t/2 20-30 minutes) Cheap Increase GFR No risk of allergic reaction
5. Colloids Suspension of particle rather than a solution High Molecular Weight: Unable to pass through semi permeable membrane Remains confined to intra-vascular compartment (at least initially) Do not correct water and electrolyte deficiencies Examples: hetastarch (Hespan), albumin, dextran
7. Colloids Most logical choice for intravascular expansion Since greater portion remains in IVC & for longer time ( t/2 3-6 hours) Less volume is required& initial resuscitation is rapid 500 ml of colloids expands plasma by 500ml colloids
10. Practical Fluid BalanceRule 1Water without Na expands the TBW (enter both ICF &ECF in proportion to their initial volume) H2O H2 O H2 O ICF ECF
11. Practical Fluid BalanceRule 2All infused Na + can not gain access to the ICF Becauseof the Sodium Pump Na + Na + Na + Na + Na + Na + ICF ECF Isotonic = NO Water Exchange Isotonic = NO Water Exchange
12. Practical Fluid BalanceRule 3Change in tonicity of Na solutions (relative to Plasma)causes water exchange a. Hypotonic saline (¼ NS) Hypotonic = Water Exchange Hypotonic = Water Exchange H 2O
13. b. Hypertonic solutionHypertonic = water exchangeHypertonic = water exchange H 2O
14. Simple guide line for replacement Prolonged vomiting and nasogastric suction : fluid of choice normal saline. If urine out put is adequate, potassium is added to it after 2 nd day. Isolyte G can be given in an amount same as upper GI loss, provided urine output renal status is normal. Fluid loss due to small bowel fistulas causing diarrhorea : RL is ideal may need additional bicarbonate and potassium supplementation to treat metabolic acidosis and hypokalemia. Loss of blood : if volume is less replacement is done with three times volume of isotonic saline or RL. But if loss is greater , it needs blood or colloids for replacement.
15. Orthostatic Hypotension• Systolic blood pressure decrease of greater than 20mmHg from supine to standing• Indicates fluid deficit of 6-8% body weight - Heart rate should increase as a compensatory measure - If no increase in heart rate, may indicate autonomic dysfunction or antihypertensive drug therapy
18. Normal Maintenance requirements Hypothetical 2000 ml/ day Volume of 30 – 35 ml.kg-1day-1 Weight Rate Solutions: D5 or D5 ½ NS 10 kg 4ml/kg/h 10 – 20 kg +2ml/kg/h > 20kg +1ml/kg/h 1.5 -2 ml/kg/h
19. Surgical Fluid Losses Blood loss Obligatory losses of fluids Redistribution – third space Evaporation
20. Blood Loss• Replace 3 cc of crystalloid solution per cc of blood loss (crystalloid solutions leave the intravascular space)• When using blood products or colloids replace blood loss volume per volume
21. Third Space Losses• Isotonic transfer of ECF from functional body fluid compartments to non- functional compartments.• Depends on location and duration of surgical procedure, amount of tissue trauma, ambient temperature, room ventilation.
22. Replacing Third Space Losses• Superficial surgical trauma: 1-2 ml/kg/hr• Minimal Surgical Trauma: 3-4 ml/kg/hr - head and neck, hernia, knee surgery• Moderate Surgical Trauma: 5-6 ml/kg/hr - hysterectomy, chest surgery• Severe surgical trauma: 8-10 ml/kg/hr (or more) - AAA repair, nehprectomy
23. Monitoring fluid therapy 1.skin and tongue: warm extremities and normal elasticity of skin. 2.sensorium:improvement of anxiety and restlessness. 3.urine output: U.O. >30-50ml/hr in adults or >.5 to 1.0 ml/kg/hr in children in absence of glycosuria or osmotic diuresis. Increased urine output with decreasing urine specific gravity and omolality are other dependable parameters 4.pulse rate: correction of tachycardia to pulse rate <110/min. change from low volume collapsing pulse to bounding pulse 5.blood pressure 6.decreasing hematocrit 7.blood urea and serum creatinine: both will become normal. 8. increase in urinary Na excretion >25 mEq/L
24. Post –operative fluid therapy Depends upon clinical judgement of the patient’s status Goal of fluid therapy: to maintain blood pressure (>100/70 mm of Hg), pulse rate <120/min and hourly urine flow between 30-50 ml along with normal temperature, warm skin, normal respiration and sensorium. Depends upon type minor, major and nature of surgery short operative procedure and donot require handling of intestine or viscera with little morbity will require only maintenance I.V. fluid to correct for the NPO state. After 4-5 hrs oral fluids is restarted and I.V. fluid is not needed i.e. hernia, minor orthopedic operations on limbs, minor plastic surgery Patients with major surgeries where intestinal viscera need rest requires postoperative I.V. fluids for a few days. After ensuring normal movement of intestine, oral fluid intake is restarted. Where handling of intestine is not required I.V. fluid is required for 24-48 hrs e.g. cardiac surgery,coronary bypass surgery, total hip replacement
25. Routine postoperative orders of I.V.fluid for first three days First 24 hrs of surgery : 2 liters 5%-dextrose or 1.5 liters 5%- dextrose +500 ml isotonic saline. Second post operative day: 2 liters of 5%-dextrose +1liter 0.9% saline. Third post operative day: similar fluid +40-60 mEq potassium per day. Maintenance fluids should be administered at a steady rate over an 18 to 24 hour period.
26. Infants respond to dehydration with decreased blood pressure but without increased heart rate. Preoperative fluid deficit replaced with RL or ½ NS
27. Fluid therapy in specialsurgical problems Turp syndrome: correction of severe and symptomatic syndrome hyponatremia should be done with slow administration of 3% hypertonic saline with I.V. frusemide. Hyper tonic saline must be given very slowly in divided doses with monitoring of serum sodium. Rapid administration of saline leads to pulmonary oedema and central pontine myelinolysis. In general TURP syndrome can be corrected with 200ml of 3% saline
28. TURP SYNDROMEDefined as serum Na+ <125mEq/L with two or moreclinical symptoms and signs.Etiology - Intravascular absorption of irrigation fluid absorption of free water dilution of serum sodiumRegional anaesthesia preferred over Generalanaesthesia.
29. Fluid therapy in neurosurgery Isotonic saline, 5% albumin and 6% hestarch are iso to hyperosmotic,so they have minor effect on the brain’s water content or ICP. So these lfuids are safe to infuse. Osmolality of RL is 274 mOsm/L and 5%-dextrose is 278 mOsmol/L. as both of them are hypotonic, they can increase ICP and cerebral oedema. So these fluid should be avoided or should be used judiciously. 5%- dextrose is hypotonic accelerates ICP and cerebral oedema.in acute ischemic brain damage produces more lactic acid free radicals which further damages the brain.
30. Guidelines of fluid managementof increased ICP Acute phase: mannitol is main stay of therapy. Prolonged administration of mannitol should be avoided. Maintenance therapy: fluid restriction and diuretics are the mainstay of maintenance therapy for ICP. The initial aim is to produce isovolumic hyperosmolality i.e. elevate serum osmolality without reducing the intravascular volume.The best fluid for this purpose is isotonic saline with added potassium chloride.
31. Fluid therapy in Burns Fluid resuscitation in first 24 hours Fluid therapy from 24 to 48 hours Fluid therapy after first 48 hours Indication of I.V. resuscitation are : 1. adults with >15-20% burns 2. child with 10% burns 3. electric burn with haemochromogens in the urine 4. the extremes of age or elderly patients with preexsisting cardiac or pulmonary disease During initial period fluid resusitation sodium rich I.V. fluid in large quantity is required.
32. RL is the most preferred fluid for initial fluid resuscitation Volume required=4×%BSA×body weight 24 hrs period from the time of burn accident Out of total fluid requirement for 24hours half is given first 8 hrs post burns and remaining half is given over the next 16 hrs Electrolyte-free fluid i.e 5%-dextrose are avoided for initial fluid resuscitation Colloid infusion is either ineffective or destructive in early period BT is usually avoided initially
33. During the second post burns day the volume of fluid infused per hour should be roughly reduced by 25-50% Fluid infused – 5% dextrose but if sodium supplementation is needed RL or .45% saline can be added The amount colloid infused after 24 hrs depends on degree of burns volume roughly 0.3-0.5 ml/kg/% of burns. Among colloids infusion albumin is often preferred
34. Fluid therapy after 48 hrs Is the sum of normal maintenance requirements plus replacements of abnormal losses Maintenance requirement contains water, sodium 3mEq/kg and potassium 2mEq/kg 5% dextrose volume required is 1ml/kg/% burns. Albumin with aim to maintain serum albumin >2.5gm/dl.
35. Summary• Fluid therapy is critically important during the perioperative period.• The most important goal is to maintain hemodynamic stability and protect vital organs from hypoperfusion (heart, liver, brain, kidneys).• All sources of fluid losses must be accounted for.
36. SODIUM (Na + ) Major cation of ECF ; Normal – 135-145mEq/L Determines ECF & ICF Osmolality Serum osmolality = 2x Na + + glucose/18 + urea/2.8 Normal – 275-290mOsm/kg Maintain ECF volume and thus Blood pressure
39. TREATMENT HYPONATREMIA (correct underlying etiology)HYPOVOLEMIA OEDEMATOUS EUVOLEMIASalt and water No salt Water restrictionsupplementation Water restriction Loop diuretics
40. TREATMENT Chronic asymptomatic hyponatremia (>48hrs): Rate of correction - 0.5 to 1.0 mEq/L/hour. MAX 8mEq/L per day. Rapid correction Central pontine demyelination Dysarthria, dysphagia, flaccid paralysis or coma
41. TREATMENT ACUTE hyponatremia with severe neurological symptoms Rapid correction with hypertonic saline 1.5 – 2mEq/L /hr for first 3-4 hours Other supportive therapy for neurological symptoms Correct until Symptoms subside Safe plasma Na+ concentration : 120-125mEq/L Na+ Requirement = (140- Na+ )x Body weight x 0.6
42. HYPERNATREMIA (Na + >145mEq/L) Etiology – Usually : water deficit Excess water loss Insensible loss Dermal -: heat exposure, severe burns Respiratory -: patients on mechanical ventilators.
43. Renal loss Diabetes insipidus central (ADH deficiency): pituitary surgery, basal skull fracture and severe head injury Nephrogenic – drugs (lithium, demeclocycline, amphoteracin B,) hypokalemia, hypercalcemia etc Excessive diuretics Uncontrolled diabetes mellitus Gastrointestinal loss : osmotic diarrhoea
44. Water deficit due to impaired thirst Primary hypodypsia, confused or comatous condition Sodium Retention Excessive I.V. Hypertonic NaCl or NaHCO3
46. TREATMENT Restoration of ECF volume: Water deficit : Plasma Na+ concentration – 140 X total body water 140 Rate of correction : 0.5mEq/L/hr and not more than 12 mEq/l over 24 hours
47. ANAESTHETIC IMPLICATION Increases the MAC of inhaled anaesthetic agents: Enhanced sodium conductance during depolarisation of excitatory membranes.
48. POTASSIUM Determines excitability of nerves and muscle cells including the myocardium. Most abundant intracellular cation: 98% intracellular.
49. Hypokalemia (K+ < 3.5mEq/L) EtiologyPoor Non renal Renal loss Redistributionintake loss•Anorexia •Vomiting Diuretics • Metabolicnervosa • diarrhoea osmotic diuresis • alkalosis, insulin,Starvation• excessive • • salt wasting nephropathy β2 agonist,alcoholism• sweating, • Mineralocorticoid excess Hypokalemic large • (primary or secondary), periodic nasogastric Cushing’s syndrome, paralysis, aspiration • Steroid therapy Vitamin B12 ** Surgical stress reduces Magnesium deficiency • therapy, serum K by 0.5 mEq/L + Amphoteracin B • Li overdose
50. Clinical Features Commonly : Fatigue, myalgia and muscular weakness of lower extremity Smooth Muscle : Constipation, ileus or urinary retention Progressive weakness, hyporeflexia, hypoventilation( due to respiratory muscle involvement) Polyuria due to nephrogenic diabetes insipidus Increased ammoniagenesis : precipitates hepatic encephalopathy in patients with hepatic failure
51. Arrythmia Early changes Flattening or inversion of T waves Prominent U waves ST segment depression Prolonged QT interval Flattening of T waves
52. Flat T wavesU waves
53. SEVERE HYPOKALEMIA Prolonged PR interval Decreased voltage Widening of QRS Ventricular arrythmia :VPC, ventricular tachycardia
54. TREATMENT Prevention of K+ Depletion Patients receiving Digitalis, long term diuretics or large dose steroids Beware in special conditions like hepatic failure, previous myocardial infarction or IHD, Diabetes Mellitus Post operative patients should receive 40 -50
55. TREATMENT When to Treat 3.5 to 4 mEq/L : No potassium supplementation Add potassium sparing diuretics or decrease dose of diuretics 3 to 3.5 mEq/L : Treat in high risk groups <3 mEq/L : Needs definitive treatment
56. IV KCl Therapy Reserved for symptomatic and severe cases Common Guidelines Continuous ECG monitoring Avoid till urine output is established Don’t give > 10- 20 mEq/L/ hour (typically 0.5mEq/kg/hr) ( 10ml of 15% KCL – 20 mEq/L) Don’t give > 40 mEq/L Don’t give more than 240mEq/ day
57. TREATMENT Treatment of acidosis with NaHCO3 may aggravate or precipitate hypokalemia. KCL infusion : In NaCl not in 5% Dextrose D5 insulin release K+ shift ICS aggravates hypokalemia(0.2-1.4mEq/L) 20mEq/hr of K Cl raises K+ by 0.25mEq/L 80% of this enters cells.
58. HYPERKALEMIA (K+ >5.5mEq/L) Etiology •Increased intake I.V fluids containing potassiumI.V.fluid Isolyte- Isolyte Isolyte- Isolyte- Ringer’ s M -P G E s lactatePotassiu m 35.0 20.0 17.0 10.0 4.0(mEq/L) High potassium containing foods Potassium containing Drugs
59. HYPERKALEMIA• Tissue breakdown Bleeding into soft tissue, G.I.tract or body cavities Hemolysis, Rhabdomyolysis Catabolic State• Shift of potassium Tissue damage Metabolic acidosis Uncontrolled Diabetes due to insulin deficiency Aldosterone Deficiency Hyperkalemic periodic paralysis, Succinylcholine
61. CLINICAL FEATURES Muscle weakness hyporeflexia paralysis affecting legs, trunk and arms (in that order) and at last respiratory muscles. Muscles supplied by cranial nerves are spared Cardiac Arrythmia 6-7 mEq/L : Tall peaked T waves 7-8 mEq/L : loss of P waves, widening of QRS complex 8-10 mEq/L : QRS merges with T waves forming sine waves >9mEq/L : AV dissociation, Ventricular tachycardia or fibrillation , Diastolic arrest.
62. CLINICAL FEATURES Lethal hyperkalemia during anaesthesia: Reperfusion of a large vascular bed after a period of ischemia. ( usually 4 hrs) Ischemia acidosis shift of K+ from ICF to ECF
63. TREATMENT Stop exogenous sources : K+ containing IV fluids, drugs etc. For mild elevation (5 to 6 mEq/L), remove potassium from the body with Diuretics : 40-80mg I.V Cation exchange Resins: Sodium polystyrene sulphonate (Kayexalate ) 15 to 30 g in 50 to 100 mL of 20% sorbitol either orally or by retention enema. Exchange sodium for potassium in G.I.tract Each gram binds 1mEq of K+ and releases 2-3mEq of sodium. Caution : CHF and volume overload patients
64. …TREATMENT For moderate elevation (6 to 7 mEq/L) , shift potassium intracellularly with Glucose plus insulin: mix 25 g (50 mL of D50) glucose and 10-20 U regular insulin and give IV over 15 to 30 minutes Initial bolus followed by continuous infusion with 5% dextrose @ 100ml/hr to avoid late hypoglycemia. K+ falls by 0.5-1.5mEq/L. effect begins in 15 mins and peaks at 60 mins. Lasts for 4-6 hours.
65. …TREATMENT Sodium bicarbonate: 50 mEq IV over 5-10 minutes less effective for treatment of patients with renal failure : do not tolerate the sodium load and resultant volume expansion Nebulized albuterol: 10 to 20 mg nebulized over 15 minutes or inj Salbutamol 0.5mg by I.V.infusion Preferred in ESRD for rapid lowering Tachycardia : I.V therapy > nebulization.
66. …TREATMENT Severe elevation (7 mEq/L with toxic ECG changes) Calcium chloride (10%) 500 to 1000 mg (5 to 10 mL) IV over 2 to 5 minutes or Calcium Gluconate 10% 10-20ml over 5-10mins to reduce the effects of potassium at the myocardial cell membrane (lowers risk of ventricular fibrillation [VF]) Avoid if patient is on digitalis.
67. TREATMENT Dialysis Hemodialysis: removal rate – 35mEq/hr Peritoneal dialysis : 15 -20% as effective as hemodialysis.
68. CALCIUM 10+/-0.5 mg/dl Mediates : Muscle contraction Exocrine, endocrine and neurocrine secretions Cell growth Transport and secretion of fluid and electrolytes. 99% present in bones, 1% in cells and 0.15% in ECF.
69. HYPOCALCEMIA Weakness Circumoral and distal paraesthesia Muscle spasm : carpopedal spasm, tetany. Mental changes: irritability, depression and psychosis.
70. CHOVSTEK’S SIGN
71. TROUSSEAU’S SIGN
72. ECG CHANGES
73. …. CLINICAL FEATURES Severe hypocalcemia : lethargy, confusion , laryngospasm, seizures or irreversible heart failure. Cataract and calcification of basal ganglia.
74. TREATMENT Acute Management 10% calcium gluconate, : 10ml – 93mg of elemental calcium 10% calcium chloride: 10ml - 273mg of elemental calcium 10% calcium gluconate 10-20 ml IV over 10 minutes. + IV infusion of 540 to 720 mg of elemental calcium (58 to 77 mL of 10% calcium gluconate) in 500 to 1000 mL D5W @ 0.5 to 2 mg/kg/ hour (10 to 15 mg/kg). OR 10% calcium chloride 5 mL () over 10 minutes, followed by 36.6 mL (1 g) over the next 6 to 12 hours IV.
75. TREATMENT Measure serum calcium every 4 to 6hours. Aim to maintain the total serum calcium concentration at 7 to 9 mg/dL. Correct abnormalities in magnesium, potassium, and pH simultaneously. Massive transfusion : for every 4 units of blood or rate> 1.5ml/kg/min – 10ml of 10% calcium gluconate. Extravasated calcium chloride – severe tissue destruction : Calcium gluconate preferred for peripheral venous administration.
76. HYPERCALCEMIA Serum calcium - 12 to 15 mg/dL. Neurologic symptoms : Depression, weakness, fatigue, and confusion at lower levels. At higher levels : Hallucinations, disorientation, hypotonicity, seizures, and coma. Renal Polyuria , nocturia, stone formation
77. CLINICAL FEATURES Cardiovascular symptoms: Upto 15mg/dl myocardial contractility increases The QT interval typically shortens when the serum calcium is> 13mg/dL. PR and QRS intervals are prolonged. Atrioventricularblock may develop and progress to complete heartblock and even cardiac arrest when the total serum calcium is > 15 to 20 mg/dL. Hypercalcemia can worsen digitalis toxicity and may cause hypertension.
78. CLINICAL FEATURES Gastrointestinal symptoms: Dysphagia Constipation peptic ulcers, and pancreatitis Muscle weakness due to hypercalcemia: decrease doses of non depolarising muscle relaxant.
79. TREATMENT Treat if Symptomatic and > 12mg/dl >15mg/dl Immediate therapy Restore intravascular volume & promote excretion infusion of 0.9% saline at 300 to 500mL/h (saline diuresis) until any fluid deficit is replaced and diuresis occurs (urine output 200 to 300 mL/h). After adequate rehydration rate to 100 to 200 mL/h.
80. TREATMENT Hemodialysis is the treatment of choice to rapidly decrease serum calcium in patients with heart failure or renal insufficiency. Chelating agents (eg, 50 mmol PO4 over 8 to 12hours or EDTA 10 to 50 mg/kg over 4 hours) may be used for extreme conditions. Furosemide (1 mg/kg IV) but avoid thiazide diuretics.
81. MAGNESIUM Magnesium is the fourth most common mineral and the second most abundant intracellular cation (after potassium) in the human body. Normal serum Mg2+ 1.8 – 3mg/dl Magnesium is necessary for the movement of sodium, potassium, and calcium into and out of cells magnesium plays an important role in stabilizing excitable membranes.
82. Mg 2+ in ANAESTHESIA PNS – interferes with release of neurotransmitters at all synaptic juctions Potentiates action of local anaesthetics. Neuromuscular Junction Significant presynaptic neuromuscular blockade Enhance action of nondepolarizing muscle relaxant Precipitate weakness in patients with myasthenia gravis and Eaton-Lambert syndrome Prolongs action of depolarizing neuromuscular blockers. Prevents K+ release by succinylcholine
83. Mg 2+ in ANAESTHESIA Severe acute asthma – effective bronchodilator Obstetric practice Powerful tocolytic – Manage premature labour. Prophylaxis and treatment of eclampsia.
84. HYPOMAGNESEMIA<1.8mg/dl Muscular tremors and fasciculations Ocular nystagmus Tetany Altered mental state Cardiac arrhythmias such as torsades de pointes (multifocal ventricular tachycardia) Ataxia, vertigo, seizures, and dysphagia.
85. TREATMENT For severe or symptomatic hypomagnesemia: 1 to 2 g of IV MgSO4 over 5 to 60 minutes. Followed by continuous infusion of 1mEq/kg/24hours. For torsades de pointes with cardiac arrest : 1 to 2 g of MgSO4 IV push over 5 to 20 minutes. For seizures - give 2 g IV MgSO4 over 10 min. Administration of calcium is usually appropriate because most patients with hypomagnesemia are also hypocalcemic.
86. TREATMENT Caution and monitoring MgSO4 therapy Check deep tendon reflex every 15mins (knee jerk) Periodic monitoring of serum Mg concentration. Reduce dose in renal failure. Contraindicated in heart block or extreme myocardial damage Maintain urine output – 100ml/4hours Overtreatment 10% calcium gluconate 10-20ml followed by fluid loading and diuretics.
87. HYPERMAGNESEMIA(>3mg/dl) Etiology Renal failure patients : most common cause Treatment of pre-eclampsia with I.V MgSO4. ARF with acute rhabdomyolysis Diabetic ketoacidosis without treatment.
88. CLINICAL FEATURES Neuromuscular Manifestations Muscular weakness muscular paresis leading to respiratory depression and respiratory failure. No effect on central respiratory drive. Cardiac manifestation Hypotension: peripheral vasodilatation Bradyarrhythmia Cardiac asystole
90. TREATMENT Eliminate source 10% calcium chloride (5 to 10 mL [500 to 1000 mg] IV) or 10% calcium gluconate will often correct lethal arrhythmias. IV saline diuresis (administration of IV normal saline and furosemide [1 mg/kg]) can be used to increase renal excretion of magnesium until dialysis can be performed. Dialysis is the treatment of choice for severe hypermagnesemia. Artificial respiration
91. PHOSPHORUS Major Buffer anion for ICF & ECF Rapid shifting can occur Functions Muscle, red blood cells & nervous system Maintains acid-base balance Adequate renal function necessary to maintain normal balance 90% excreted by kidneys
92. PTH regulates levels Increases resorption from bone Inhibits reabsorption in renal tubules Increases absorption from GI tract Calcium and phosphate or inversely proportional PTH = PO4³¯& Ca+ Normal: 2.8 - 4.5 mg /dl