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University cross discipline presentation oct 16, 2013
 

University cross discipline presentation oct 16, 2013

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The Avon Foundation, the National Cancer Institute and Center for Advancing Innovation have partnered to create a "first of a kind" Breast Cancer Start-up Challenge; you can find the website here:

The Avon Foundation, the National Cancer Institute and Center for Advancing Innovation have partnered to create a "first of a kind" Breast Cancer Start-up Challenge; you can find the website here:
http://www.breastcancerstartupchallenge.com!

The Challenge features Breast Cancer Inventions (9 from the National Institutes of Health National Cancer Institute and 1 from an Avon Foundation grantee) that have commercial viability and are important to public health. The primary goal of the Challenge is to stimulate the creation of start-up businesses based upon these inventions.

We currently have teams from Wake Forest, UNC, NYU, Ohio State, Rutgers, Mount Sinai Hospital, etc. You can find the full list of teams in the Challenge here: http://www.breastcancerstartupchallenge.com/teams-participating.html. Another 20+ teams are forming and nearly done!

If you know of an innovative self-starter in your University that may have interest in entering the challenge, please share this information and encourage them to enter. While three students must be on each team, the mandatory disciplines (legal, medical/scientific, business and entrepreneurship) for the teams can come from anywhere. The deadline to enter the challenge – the Letter of Intent phase - is November 29, 2013.

Please share your enthusiasm and follow us on our social media for the latest updates on the Challenge:

Breast Cancer Start-up Challenge

@TheBCSChallenge

Contact Rosemarie Truman, CEO of CAI for more information at rt@thecenterforadvancinginnovation.org or 202 438 2208.

Regards,


Rosemarie Truman

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    University cross discipline presentation oct 16, 2013 University cross discipline presentation oct 16, 2013 Presentation Transcript

    • the center for |"advancing innovation The  Avon  Founda-on,  Na-onal  Cancer  Ins-tute  and     Discussion Document: July 6, 2009 Center  for  Advancing  Innova-on  Business  Plan  and  Startup  Challenge     University  Presenta-on     By:     Rosemarie  Truman,  Founder  and  CEO,  The  Center  for  Advancing  Innova-on     October  16,  2013  
    • What  is  the  Challenge:  Develop  a  business  plan  and  launch  a  startup  using  10  near-­‐ term,  commercially  viable  inven-ons     Challenge  Overview   •  Business  Plan  (BP)  and  Startup  Contest  using  10  near-­‐term,  commercially  viable  inven8ons  conceived   and  developed  by  inventors  from  the  NCI  and  an  Avon  Founda8on  (AF)  grantee   •  Challenge  teams  will  par8cipate  in  three  phases:  LeFer  of  Intent,  Business  Plan  and  Start-­‐up     Goals:   •  Breast  Cancer  (BC):  Increase  survivability  and  improve  the  standard  of  care  in  areas  of  unmet  need   •  Technology  Transfer  (TT)  Memorandum:  “Accelerate  and  increase  the  volume  of  Federally  funded   technology  transfer  in  support  of  high  growth  businesses”   •  Economic  Growth:  Spur  economic  growth  across  the  na8on  through  new  startups  and  jobs   •  Entrepreneurship  Learning:  Provide  a  plaLorm  for  Universi8es  to  expand  their  entrepreneurial   programs   •  Business  Model:  Create  new  business  models  in  TT,  transla8onal  research  and  R&D  funding   Phases:  Three  phases  -­‐  Challenge  Teams’  Opportunity:     •  Business  Plan  Prize:  Up  to  100  teams  will  par8cipate,  10  teams  per  inven8on.  There  will  be  one  $5K   prize  per  inven8on  ($50k  in  total  awards)     •  Start-­‐up  Phase  Seed  Funding:  Up  to  30  successful  start-­‐ups  will  apply  and  poten8ally  be  awarded   funding  which  could  range  from  $100K  to  over  $1MM     •  Funding  will  come  from  venture  capital,  economic  development  corpora8ons,  Avon  Founda8on  or   other  private  sources.  Funding  will  not  be  provided  from  the  NIH     2 Proprietary and Confidential to The Center for Advancing Innovation. Do not distribute outside The Center for Advancing Innovation
    • Who  are  the  key  players?     Judges/Mentors   Seed  Funders   •  Economic   Development   organiza8ons   •  Venture  capital   •  Private  equity   •  Angel  investors   •  •  •  •  •  Breast  Cancer  Survivors   Venture  Capitalists   Successful  Serial  Entrepreneurs   Industry  Execu8ves  and  Experts   Founda8on,  NCI  and  CAI  Core  Team   Core  Partners:     •  The  Avon  Founda8on   •  Na8onal  Cancer  Ins8tute   •  The  Center  for  Advancing  Innova8on   Universi8es   Supporters   BIO       SoPE       CoFoundersLab     •  Students  gain:  real-­‐world,  cross-­‐discipline,   entrepreneurship  experience;  gain  exposure  to  experts   •  Universi/es  gain  publicity  for  providing    entrepreneurial   student  opportuni8es  and  new  way  to  create  jobs   3 Proprietary and Confidential to The Center for Advancing Innovation. Do not distribute outside The Center for Advancing Innovation
    • Challenge  Topics:  Novel,  Commercially  Viable  Breast  Cancer  Inven-ons   NCI  Inven-on  Example   Breast  Cancer  Challenge  Topics   Therapeu8cs:  5   Diagnos8cs:  5   Prognos8cs:  1     Vaccine:  1   Health  IT:  1   Device:  1   Delivery  Method:  1   Note:  some  inven8ons  have  more  than  one  use     and  cover  2  or  more  of  the  above   4 #1  -­‐  Diagnos-c  from  Biopsies  with   SoYware  Analysis   Title:    Breast  Cancer  Diagnos-c   Based  on  Spa-al  Organiza-on  of   Genes  in  the  Cell  Nucleus     Execu-ve  Summary     Category:  Diagnos8cs/Health  IT   Disease  Focus:  Breast  Cancer  using  tumor   biopsies       Basis  of  Inven-on:  Gene  (DNA)     How  it  works:    Uses  the  3D  placement  of   genes  to  detect  breast  cancer  in  8ssue   Patent  Status:  Patent  issued  in  Europe   (validated  in  Germany,  UK,  France),   pending  in  US,  Canada   Lead  Inventor:  Tom  Misteli,  PhD   Development  Stage:    In  vitro  and   retrospec8ve  in  vivo   Proprietary and Confidential to The Center for Advancing Innovation. Do not distribute outside The Center for Advancing Innovation
    • Who  can  par-cipate?    Challenge  TEAM   Team  Design:     Mandatory  Requirements*   Business   Legal   Medical/Scien8fic   Seasoned   Entrepreneur     •  Over  18  years  old   •  At  least  three  students  on  the  team   *Note:  two  inven8ons  require  addi8onal  disciplines   Inven8on  #1:  computer  science;  inven8on  #3:  engineering   5 Other  Key  Notes  on     Who  May  Par-cipate     Students:   •  Graduate  and  undergraduate   Students   •  Post-­‐docs,  those  in  residency     Anyone  else  beyond  the  three   mandatory  students     Others  Areas  of  Recommended   Knowledge  Sources:   •  Business  development   •  Payers   •  Key  Opinion  Leader   •  FDA/Regulatory   •  Venture  Capital   •  Clinical  Research  Outsourcer   Proprietary and Confidential to The Center for Advancing Innovation. Do not distribute outside The Center for Advancing Innovation
    • Overview  of  Phases:  100  teams  enter;  a  poten-al  of  30  startups   Planning Phase 1: Letter of Intent 10   Inven-ons   10  Teams  for   Each  Inven-on   Inven-on  1   •  Select  an   inven8on   •  Form  a   team   6 •  Enter  your   core  team,   mentors,   advisors  and   collaborators   Phase 2: Business Plan Phase 3: Startup Post-Contest 3  Teams  per   3  Startups  for  Each   “Startup  Winner”   Inven-on  Go  to  Ph3   Inven-on   Has  Licensing   Agreement  and   Seed  Funding   Inven-on  1   •  Business  Plan   •  Revise  Business   •  Pitch   Plan     •  Elevator   •  Launch  Startup   Speech   •  Apply  for  seed   funding   •  Apply  for  a   license   •  Collaborate   with  the  NCI  or   AF  grantee   University,   Clemson   •  Launch  a   Product   Proprietary and Confidential to The Center for Advancing Innovation. Do not distribute outside The Center for Advancing Innovation
    • Lecer  of  Intent:  Guidelines,  Deliverables  and  Key  Dates   Phase  1:   10  Teams  for   Each  Inven-on   Inven-on  1   7 Letter of Intent Deliverables:   •  LeFer  of  Intent  form  (it  contains  a  CDA  click  through)   •  Prize  Alloca8on  Form   •  Resumes  (one  package  containing  all  resumes  of  core  team  members,   mentors,  and  advisors)   •  Join  Wiggio;  create  group  and  invite  CAI  to  your  group   •  OPTIONAL:  Stakeholder  Analysis  and  Collaborators     Guidelines:   •  Augment  your  team  with  Venture  Capitalists  who  may  provide  funding   •  Iden8fy  collaborators  that  can  provide  seed  funding  and/or  services  to   your  start-­‐up  (e.g.,  legal,  accoun8ng,  valua8on,  etc.)   •  Include  team  members  that  have  relevant  inven8on  experience   •  Prepare  a  strong  LOI  with  all  disciplines  required,  mentors  and  advisors.   We  are  accep8ng  strong  teams  on  a  rolling  basis     Key  Dates:  October  1st,  2013  to  November  29,  2013   •  Start  accep8ng  LOIs:  October  1st;  Stop  accep8ng  LOIs,  December  1st,  2013   •  Receive  final  LOI  communica8on  by  December  4th  ,  2013     Proprietary and Confidential to The Center for Advancing Innovation. Do not distribute outside The Center for Advancing Innovation
    • Challenge  Team  Member  Defini-ons   Challenge  Team  Defini-on:  The  “Challenge  Team”  is  made  up  of  the  Team   Leader,  Core  Team  Members,  Advisors,  Mentors     A  Team  Leader  is  our  single  point  of  contact  for  the  Challenge  and  accountable   for  deliverables     A  Core  Team  Member  is  accountable  for  deliverables     A  Mentor  has  domain  experience  and  will  ac8vely  work  with  the  team  on  a  daily/ weekly  basis  to  review/complete  deliverables     An  Advisor  has  domain  exper8se  and  the  team  uses  for  Q&A  sessions,  e.g.,  KOL     A  Collaborator  is  an  organiza8on  that  can  improve  your  probability  of  success;   they  will  include  seed  funders,  services  firms,  etc.   8 Proprietary and Confidential to The Center for Advancing Innovation. Do not distribute outside The Center for Advancing Innovation
    • Business  Plan:  Guidelines,  Deliverables  and  Key  Dates   Phase  2:   Business Plan Deliverables:   3  Teams  per   •  10  page  business  plan  or  a  business  model  canvas   Inven-on  Go  to  Ph3   •  1  minute  elevator  pitch  posted  on  YouTube   •  5  minute  live  pitch  via  Skype  or  video  conferencing  to  judges   •  10  page  pitch  deck  (maximum  10  pages  Powerpoint  or  Prezio)     Guidelines:   •  Begin  with  the  end  in  mind.  Make  sure  you  understand     •  Seed  funders  criteria  for  investment   •  NIH  or  Clemson’s  license  agreement  requirements   •  Leverage  CAI’s  templates/guidelines  for  your  business  plan,  regulatory   strategy,  development  plan,  and  commercializa8on  plan,  etc.     •  Check  the  criteria  we  are  using  to  assess  deliverables   Key  Dates:     •  Deliverables  due:  February  3rd  (can  be  submiFed  early)   •  Pitches:  February  3rd  to  February  13th     •  Award  Announced:  February  19th     Prize:  $5K  for  each  of  10  winning  teams–  one  award  per  inven8on     9 Proprietary and Confidential to The Center for Advancing Innovation. Do not distribute outside The Center for Advancing Innovation
    • Start-­‐up:  Guidelines,  Deliverables  and  Key  Dates   Phase  3:   Start-up 3  Startups  for  Each   Deliverables:   •  Revised  regulatory  strategy,  commercializa8on  plan  and  development  plan   Inven-on   •  Start-­‐up  incorpora8on   •  Seed  funding  applica8on(s)   •  NIH  or  Clemson  licensing  applica8on     Inven-on  1   Guidelines:   •  Incorporate  your  start-­‐up  as  soon  as  possible   •  Revise  your  deliverables  by  gaining  addi8onal  input  from  KOLs,  payers,  the   FDA,  VCs,  poten8al  collaborators,  CROs,  CMOs,  service  providers,  etc.   •  Parallel  process  your  deliverable  crea8on  –  especially  seed  funding  and   licensing  applica8on;  there  could  be  a  “chicken  or  the  egg”  scenario     Key  Dates:     •  Start  date:  February  20,  2014   •  Deliverables  due:  June  17,  2014   •  Awards  announced:  June  27,  2014  (or  later)   Defini-on  of  Success:  Start-­‐ups  launched  a  company;  raised  capital  and  in-­‐ licensed  an  inven8on.    Successful  start-­‐ups  are  honored  with  a  “Start-­‐up   Medal  of  Honor”  in  an  awards  ceremony   10 Proprietary and Confidential to The Center for Advancing Innovation. Do not distribute outside The Center for Advancing Innovation
    • Post-­‐Challenge  Expecta-ons   Avon  Founda-on:  Ongoing  partnering  to  ensure  success         NCI/Clemson  University  Research  Founda-on:  Ongoing  Collabora8on         The  Center  for  Advancing  Innova-on:  Ongoing  coaching/mentoring       EVENTUALLY:  NEW  BREAST  CANCER  PRODUCTS/SOLUTIONS  ON  THE  MARKET   11 Proprietary and Confidential to The Center for Advancing Innovation. Do not distribute outside The Center for Advancing Innovation
    • More  on  the  inven-ons,  page  1  of  2   #1  –  Health  IT  Inven8on  –  Detects  Breast  Cancer  based  on  Spa8al  3D  Gene  Placement   Tom  Misteli,  Patents  issued  in  Europe  (validated  in  Germany,  UK  and  France)  pending  in  US/Canada   In  vivo  and  in  vitro  data   #2  –  Therapy/Vaccine–  Slows  tumor  growth,  preven8ng  metastasis  post  surgery   Dennis  Klinman,  Patent  pending  in  the  US,  pre-­‐clinical  in  mice   #3  –  Device/Therapeu8c/Vaccine–  Collagen  composite  8ssue  replacement  material  as  a   reconstruc8on  plaLorm  with  an8-­‐tumor  capabili8es   Karen  Burg,  Patent  issued  in  the  US,  human  breast  8ssue  tested  in  pre-­‐clinical   #4  –  Therapeu8c/Diagnos8c  –  Binds specifically to a cancer cell target and inhibits the tumor growth   Mitchell  Ho,  US  patent  pending,  in-­‐vitro  data  also  mouse  xenograph  models   #5  –  Therapeu8c/Vaccine–  S8mulates  immune  response  for  tumor  inhibi8on   Alan  Krensky,  Patent  Pending  in  US,  Canada,  Australia,  and  Europe,  pre-­‐clinical  in  mice     12 Proprietary and Confidential to The Center for Advancing Innovation. Do not distribute outside The Center for Advancing Innovation
    • More  on  the  inven-ons,  page  2  of  2   #6  –  Therapeu8c–  Small  molecule  that  works  with  current  drugs  to  enhance  their  effec8veness   Nayda  Tarasova,  US  patent  issued;  Europe,  patent  pending;  pre-­‐clinical  in-­‐vitro   #7  –  Two  Inven8ons  Vaccine  and/or  Drug  Delivery  –  PlaLorm  to  deliver  proteins  to  cancer  cells  –   much  less  toxic  and  more  specific  than  current  models   Deb Chatterjee,  Patents  issued  in  US;  another  pending,  in  vitro  and  in  vivo  data   #8  –  Diagnos8c–  Uses  genes  to  detect  Cancer  and  associated  stage   Steven  Libus,  US  patent  pending,  retrospec8ve  human  data  from  clinical  trials   #9  –  Diagnos8c–  Predict  pa8ents  survival  rate  and  guides  treatment   Stephen  HewiF,  Pending  in  U.S.,  Canada,  Europe,  Australia,  Japan,  Israel,  and  New  Zealand,  more   than  a  thousand  samples  of  human  data     #10  –  Diagnos8c–  Determines  the  effec8veness  of  chemotherapy  for  a  pa8ent     Sherry  Yang,  US  patent  granted;  Pending  in  Europe,  Canada,  Australia,  and  Japan,  data  from  >1500   human  8ssue  samples   13 Proprietary and Confidential to The Center for Advancing Innovation. Do not distribute outside The Center for Advancing Innovation
    • SUMMARY:  Key  Dates   Under  the  “Overview”  Sec-on  on  hcp://www.breastcancerstartupchallenge.com   Key  Dates   LeFer  of  Intent       Oct  1-­‐Nov  29  2013   • 8/30/13  –  10/1/13:  Form   team   • 10/1/13:  Submit  LOI   • 11/29/13:  LOIs  due   • 12/4/13:  Communicate  to   teams   Ongoing   14 Business  Plan     Dec  2  2013  –     Feb  19  2014   • 12/2/13:  Launch  BP  effort   • 2/3/14:  Deliverables  due   • 2/3/14  –  2/13/14:  Virtual   pitches  with  teams   • 2/19/14:  Award  top   teams  for  each  inven8on   Start-­‐up     Feb  20,  2014-­‐     June  27,  2014     • 2/20/14:  Launch  SU  effort   • Ongoing:  Revise  BP;   create  SU;  apply  for   funding  and  license   • 6/17/14:  Deliverables  due   • 6/27/14:  Announce   successful  start-­‐ups   An8cipated  Post-­‐ Contest  Ac8vi8es   • Conduct  discussions   regarding  collabora8ve   R&D  agreement   • Con8nue  R&D  on   inven8on   • Con8nue  raising  capital   •  Provide  mentoring  /  guidance  to  teams   •  Receive  ques8ons  and  filter  to  SMEs  as  necessary   •  Review  rolling  BP  and  SU  deliverables Proprietary and Confidential to The Center for Advancing Innovation. Do not distribute outside The Center for Advancing Innovation
    • Key  Links   Challenge  Website     hFp://www.breastcancerstartupchallenge.com     LeFer  of  Intent  Forms  –  For  Teams   Team  Leader     hFps://www.surveymonkey.com/s/TeamLeadLOISurvey     Core  Team  Members,  Mentors,  Advisors  and  Collaborators:     hFps://www.surveymonkey.com/s/BCSChallengeCDAForm     Wiggio  Links  –  For  Teams      Main  Group    hFp://wiggio.com/group_open_join.php?  groupid=1838019&password=CAI1234&ref=1787839     Team  Collabora8on   hFp://wiggio.com/group_open_join.php? groupid=1848688&password=CAITEAM&ref=1787839   15   Proprietary  and  Confiden8al  to  The  Center  for  Advancing  Innova8on.  Do  not  distribute  outside  The  Center  for  Advancing  Innova8on    
    • Connect  with  us!   Facebook    -­‐  Breast  Cancer  Start-­‐up  Challenge     TwiFer  -­‐    @BCSChallenge     Ques-ons:  Contact  Rosemarie  Truman,     rt@thecenterforadvancinginnova-on.org   16   Proprietary  and  Confiden8al  to  The  Center  for  Advancing  Innova8on.  Do  not  distribute  outside  The  Center  for  Advancing  Innova8on