Articulo 1

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Articulo 1

  1. 1. a O2 O2.- b O2 O2.- Nox1 p22phox Nox2 p22phox H+ + NADP+ H+ + NADP+ NADPH NOXO1 NADPH P47 NOXA1 P67 phox phox Rac Rac GTP GTP c O2 H2O2 d O2 O2.- O2.- Nox4 p22phox Nox5 Ca2+ H+ + NADP+ H+ + NADP+ NADPH NADPH --
  2. 2. - tat
  3. 3. - - - - a b NOX1 NOX2 NOX4 O2.- H2O2 - NO ONOO- Improved Vascular Endothelial endothelial remodeling dysfunction function top Ach Tg SBP DBPP
  4. 4. . -- -- . -- . . -- --- tat
  5. 5. b . a aj
  6. 6. a WT/Sham KO/Sham WT/Band KO/BandABC b Stress (hypertension) Myocardial hypoxia Preservation of capillaries Hydroxylated HIF-1α Nox4 stable HIF-1α HIF-1 complex VEGF α β VEGF-HRE WT Panel A scale barpanel B panel C scale bars l .
  7. 7. WT. .
  8. 8. --
  9. 9. --
  10. 10. -

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