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    • University of Texas Southwestern Medical Center at Dallas CURRICULUM VITAE Prepared 6/2005 Name: Richard Joseph Auchus Current title and department: Associate Professor of Internal Medicine 2005-present EDUCATION: 1978-82 Massachusetts Institute of Technology, Cambridge, MA 1982 S.B. Chemistry 1982-88 Washington University, St. Louis, MO 1988 M.D. Medicine Ph.D. Pharmacology 1988-91 University of Iowa Hospitals & Clinics, Iowa City, IA Resident Internal Medicine 1991-93 UTHSC-San Antonio/Wilford Hall MC, San Antonio, TX Fellow Endocrinology 1993-95 Wilford Hall USAF Medical Center, Lackland AFB, TX Staff M.D. Endocrinologist 1995-96 University of California, San Francisco Res. Fellow Pediatric Endocr. LICENSES, CERTIFICATIONS, ETC.: 1988 Medical License (Training), Iowa 1991 Medical License, Pennsylvania 1991 Certified, American Board of Internal Medicine (field: internal medicine) 1993 Certified, American Board of Internal Medicine (field: endocrinology, diabetes, & metabolism) 1995 Medical License (Training), California 1996 Medical License, California, #G083390 2000 Medical License, Texas (L0004) PRINCIPAL POSITIONS HELD: 1981-82 Mass. Institute of Technology, Cambridge, MA Teaching Assistant in Chemistry 1984-85 Washington University, St. Louis, MO Teaching Assistant in Cell Biology 1984-87 Washington University, St. Louis, MO Teaching Assistant in Pharmacology 1993-95 Wilford Hall Medical Center, Lackland AFB, TX Staff Endocrinologist and Endocrinology Research and Education Coordinator 1996-99 University of CA, San Francisco Asst. Res. Endocrinologist, Pediatrics 1999-2005 University of TX, Southwestern Medical School Assistant Professor of Internal Medicine ANCILLARY POSITIONS HELD CONCURRENTLY: 1993-94 Univ. of TX Health Sciences Center, San Antonio, TX Clinical Instructor of Medicine 1994-95 Univ. of TX Health Sciences Center, San Antonio, TX Clinical Asst. Prof. of Medicine 1993-95 Uniformed Services Univ. of Health Sci., Bethesda, MD Assistant Professor of Medicine 1997-99 University of CA, San Francisco Asst. Clinical Prof. of Medicine 1997-99 San Francisco General Hospital, San Francisco, CA Staff Endocrinologist 2000-now Parkland & ZLU Hospitals, Aston Clinic, VANTHCS Staff Endocrinologist 2001-now St. Paul Medical Center Staff Endocrinologist
    • HONORS AND AWARDS: 1980 AFROTC General Dynamics Award 1981 Atlantic Richfield Prize, MIT Chemistry Department 1982 AFROTC Legion of Valor 1982 Alpha Chi Sigma Prize, MIT Chemistry Department 1982 AFROTC William Randolph Lovelace Award; Distinguished Graduate 1982 Phi Beta Kappa, Xi Chapter, MIT 1987-88 Olin Fellow, Division of Biology and Biological Sciences, Washington University 1995-96 Howard Hughes Medical Institute Postdoctoral Fellow 1996 Air Force Commendation Medal 1997 Endocrine Society Travel Award 1999 Merck Scholar, University of Texas Southwestern Medical School 2004-now Reynolds Associate, University of Texas Southwestern Medical School MEMBERSHIPS IN PROFESSIONAL ORGANIZATIONS: 1982-88 American Chemical Society (associate member) 1991-95 Society of Air Force Physicians 1991-95 Society of Uniformed Endocrinologists 1988-now American College of Physicians/American Society of Internal Medicine 1995-now Endocrine Society 2001-now Dallas County Medical Society/Texas Medical Association PROFESSIONAL ACTIVITY SERVICE TO PROFESSIONAL PUBLICATIONS: 1996-now Endocrinology ad hoc referee 1996-now DNA and Cell Biology ad hoc referee 1996-now Endocrine ad hoc referee 1997-now Biochemistry ad hoc referee 1997-now Proc Natl Acad Sci (USA) ad hoc referee 1999-now Metabolism ad hoc referee 1999-now J Biological Chemistry ad hoc referee 2000-now J Clinical Endocrinology & Metab ad hoc referee 2000-now Molecular Endocrinology ad hoc referee 2000-now Molecular Genetics & Metab ad hoc referee 2001-2004 Clinical Endocrinology member, editorial board 2004-now J Invest Med member, editorial board OTHER PROFESSIONAL SERVICE: 1982-now Massachusetts Institute of Technology, Cambridge, MA Educational Council 1984-87 MIT Club of St. Louis Sec.-Treasurer/VP/President 1984-87 Washington University, St. Louis, MO Ad Hoc Curriculum Committee 1995-2001 American Board of Internal Medicine Exam Contributor 2004-2005 MKSAP14 Endocrinology & Metabolism Committee Member, Writer 2005-now Endocrine Society Government Relation Committee
    • SCIENTIFIC AND PROFESSIONAL MEETINGS & WORKSHOPS ATTENDED: INTERNATIONAL Euroimmunoanalyse '93, Lyon, France, 1993 (invited lecture) 2nd International Symposium on Molecular Steroidogenesis, Monterey, CA, 1996 (poster session) 10th International Conference on Cytochrome P450, San Francisco, CA, 1997 (poster discussion) 17th International Congress of Biochemistry and Molecular Biol./ASBMB, San Francisco, CA, 1997 8th Adrenal Cortex Conference, Orford, Quebec, Canada, 1998 (invited lecture) 9th Adrenal Cortex Conference, Toronto, Ontario, Canada, 2000 (invited lecture) 2nd International Symposium on the Developmental Aspects of Androgen Excess, Toronto, Ontario, Canada, 2000 (invited lecture) 12th International Conference on Cytochrome P450, La Grande Motte, France, 2001 (invited lecture) 10th Adrenal Cortex Conference, San Francisco, CA, 2002 (invited lecture) 11th Adrenal Cortex Conference, New Orleans, LA, 2004 (session chair) 14th International Conference on Cytochrome P450, Dallas, TX 2005 NATIONAL American Chemical Society, 1986 (poster session) Magnetic Resonance in Biology and Medicine Gordon Research Conference, 1986 (poster session) Genetics and Molecular Biology of Breast Cancer, Cold Spring Harbor Laboratories, 1992 Endocrine Society, 1992, 1993 (poster), 1995 (2 posters), 1996, 1997 (paper), 1998 (poster), 1999 (poster), 2000 (poster), 2001 (2 posters, 2 papers), 2002 (5 posters, paper), 2003 (paper), 2004 (2 papers), 2005 (2 posters, invited lecture) American Diabetes Association, 1992, 1993, 1995 National Diabetes Advisory Board, Phoenix, AZ, 1993 (ad hoc member) Recent Progress in Hormone Research, Stevenson, WA, 1995 Howard Hughes Medical Institute Fellows’ Meeting, Chevy Chase, MD, 1997 (paper) National Athletic Trainers’ Association 53rd Annual Meeting, Dallas, TX, 2002 (invited speaker) U. S. Anti-Doping Agency GC/C/IRMS Conference, Los Angeles, CA, 2003 (invited speaker) Puerto Rico Urological Association 54th Annual Meeting, San Juan, PR, 2003 (invited speaker x2) American Society of Nephrology, Renal Week 2005, Philadelphia, PA, 2005 (invited speaker) REGIONAL American College of Physicians (ACP), Iowa Chapter, 1990 (paper) ACP, Air Force Chapter, 1992 (3 papers), 1993 (4 papers), 1994 (paper), 1995 (paper) San Antonio Breast Cancer Symposium, San Antonio, TX 1992, 1993 (poster session), 1994, 1995 Symposium on Cancer Research in San Antonio, 1992, 1993 (poster session), 1994 Society of Uniformed Endocrinologists, 1992, 1993 (paper), 1995 (2 papers) UCSF Pediatrics Research Retreat 1996 (poster session), 1997 (paper), 1998, 1999 Medical Student Research Forum, UT Southwestern 2001 (poster) First Southwest P450 Meeting, Camp Allen, Navasota, TX, 2001 (2 papers, poster) First Annual UT Endocrine Surgery Symposium, Dallas, TX, 2002 (invited speaker) Third Southwest P450 Meeting, Camp Allen, Navasota, TX, 2003 (paper) St. Louis Section ACS Award Symposium, St. Louis, MO, 2004 (invited speaker) Texas Chapter, American Society of Hypertension, Dallas, TX, 2004 (invited speaker)
    • INVITED PAPERS, LECTURES, PRESENTATIONS not listed above: 1990 Wilford Hall Medical Center, Lackland AFB, TX, Endocrine Conference Visiting Speaker 1992-95 Expert Testimony, Anabolic Steroid Abuse and Therapy, US Air Force and Army 1993 Cameron and Willacy County Medical Society, Brownsville, TX, Monthly Meeting Speaker 1994 All Saints' Hospital System, Ft. Worth, TX, Internal Medicine Grand Rounds 1994 Wilford Hall Medical Center, Lackland AFB, TX, Internal Medicine Grand Rounds 1994 U.C. Davis Medical Center, Sacramento, CA, Weekly Endocrine Conference 1994 David Grant Medical Center, Travis AFB, CA, Visiting Professor 1995 San Antonio Urology Nurses' Society, San Antonio, TX, Monthly Meeting Speaker 1995 Brooke Army Medical Center, Ft. Sam Houston, TX, Visiting Professor/Grand Rounds 1995 Keesler Medical Center, Keesler AFB, MI, Internal Medicine Grand Rounds 1995 Val Verde Count Medical Society, Del Rio, TX, Monthly Meeting Speaker 1995 Randolph AFB Clinic, San Antonio, TX, Visiting Professor (two lectures) 1996 Texas Academy of Family Physicians Annual Meeting, Invited Speaker 1996 Wilford Hall Medical Center, Lackland AFB, TX, Endocrine-Surgery Joint Conference 1996 U. TX Health Sciences Center, San Antonio, TX, Weekly Endocrinology Conference 1997 Am. Society of Reproductive Medicine Annual Meeting, Cincinnati, OH, Plenary Lecture 1998 U. TX Health Sciences Center, San Antonio, TX, Weekly Endocrine Research Conference 1998 U. TX Health Sciences Center, San Antonio, TX, Weekly Endocrinology Conference 1998 SFGH Program in Cellular and Molecular Medicine, Weekly Seminar 1998 UCSF Endocrine Grand Rounds, San Francisco, CA 1998 UCSF Reproductive Endocrinology Center, San Francisco, CA Weekly Seminar 1999 SFGH Pediatrics Grand Rounds, San Francisco, CA 1999 UCSF Pediatrics Grand Rounds, San Francisco, CA 1999 UT Southwestern Green Center for Reproductive Sciences, Weekly Seminar, Dallas, TX 2000 Endocrinology Grand Rounds, UT Southwestern, Dallas, TX 2000 Grand Rounds, Baylor Hospital, Garland, TX 2001 Hypertension Grand Rounds, UT Southwestern, Dallas, TX 2001 x2 Clinical-Pathologic Conference Discussant, UT Southwestern, Dallas, TX 2001 Internal Medicine Grand Rounds, UT Southwestern, Dallas, TX 2001 Kaufman County Medical Society, Dallas, TX, Monthly Meeting Speaker 2002 Pediatrics Grand Rounds, Childrens’ Hospital & UT Southwestern, Dallas, TX 2002 x2 STARS Symposium, UT Southwestern, Dallas, TX 2002 Physical and Rehabilitation Medicine Grand Rounds, UT Southwestern, Dallas, TX 2003 Indiana Endocrine Society Monthly Meeting, Indianapolis, IN 2003 Hypertension Grand Rounds, UT Southwestern, Dallas, TX 2003 Milwaukee Urology Society Quarterly Meeting, Milwaukee, WI 2003 Clinical Biochemistry Grand Rounds, UT Southwestern, Dallas, TX 2004 Basic Science Seminar Series, Reproductive Endocrinology, Mass. Gen. Hosp., Boston, MA 2004 Androgen Insensitivity Support Group, Annual Meeting, Madison, WI 2004 Internal Medicine Grand Rounds, UT Southwestern, Dallas, TX 2005 Internal Medicine Grand Rounds, Louisiana State University, Shreveport, LA 2005 Internal Medicine Grand Rounds, Wilford Hall Medical Center, Lackland AFB, TX 2005 Hypertension Weekly Conference, University of Alabama, Birmingham, AL 2005 Internal Medicine Grand Rounds, UTHSCSA, San Antonio, TX
    • POSTGRADUATE AND CONTINUING EDUCATION COURSES ATTENDED: 1992 Harvard Medical School Clinical Endocrinology Review 1993 Endocrine Fellows' Foundation/NIH Clinical Endocrinology Review 1994 Harvard Medical School Clinical Endocrinology Review UNIVERSITY SERVICE: CLINICAL SERVICE: 1997-99 Attending Physician, SFGH endocrinology inpatient service (1 month/year) 1997-99 Attending Physician, SFGH endocrinology outpatient clinic (1-2 days/month) 2000-now Attending Physician, Parkland Hospital, Aston Center, Zale Lipshy University Hospital, and VANTHCS endocrinology clinics and inpatient consult services 2002-now Chair, Data Safety and Monitoring Board, Diabetic Nephropathy Study (R. Toto, PI) 2005-now Search Committee, Touchstone Diabetes Center GRADUATE STUDENTS: 2000-now Oral Qualifying Exam Committee, Molecular Biophysics & Biological Chemistry Programs 2002-now Thesis Committee, Omid Soltani, Biological Chemistry/Chemical Biology Program 2003-now Thesis Committee, Nicholas Malmquist, Biological Chemistry Program (chair) 2003-now Member, MSTP Steering Committee, UTSW 2004-now Thesis Committee, Erin Hogan, Biological Chemistry Program 2004-now Thesis Committee, Najeeb Halabi, Molecular Biophysics Program PUBLIC SERVICE: 1991 Medical Volunteer, Camp Independence Diabetes Program, San Antonio, TX 1992 Catechist, St. Brigid's Church, San Antonio, TX 1995 Medical Volunteer, Senior Olympics, San Antonio, TX 1996 Medical Volunteer, Bearskin Meadow Diabetes Camp, King's Canyon, CA 2000 Medical Volunteer, Camp New Horizon, Dallas, TX 2002-03 Team Diabetes, Orlando Marathon Team, American Diabetes Association, Dallas, TX 2003-now Consultant, US Anti-Doping Agency, Colorado Springs, CO TEACHING: FORMAL SCHEDULED CLASSES UCSF Class Qtr. Acad.Yr. Course No. & Title Nature of Contribution Units Size S 1995-96 Physiology 101 (Endocrine and GI) Conference Leader 5 20-25 S 1996-97 Physiology 101 Conference Leader 5 20-25 S 1997-98 Physiology 101 Conference Leader 5 20-25 S 1998-99 Introduction to Clinical Medicine Lecturer 5 120 S 1998-99 Physiology 101 Conference Leader 5 20-25
    • UT Southwestern Qtr. Acad.Yr. Course Title Nature of Contribution Hours Size S 1999-00 Endocrinol. & Human Reproduction Lecturer 1 200 S 1999-00 Chemical Biology Special Topics Conference Leader 2 2 F 2000-01 Core Course, Proteins Thread Conference Leader 5 12 F 2000-01 Enzymology Lecturer (2 lectures) 3 15 S 2000-01 Endocrinol. & Human Reproduction Lecturer (2 lectures) 2 200 S 2000-01 Chemical Biology Special Topics Conference Leader 2 3 F 2001-02 Core Course, Proteins Thread Conference Leader 5 12 F 2001-02 Enzymology Lecturer (2 lectures) 3 20 S 2001-02 Endocrinol. & Human Reproduction Lecturer 1 200 F 2002-03 Core Course, Proteins Thread Conference Leader 5 12 F 2002-03 Enzymology Lecturer (2 lectures) 3 18 S 2002-03 Chemical Biology, Synthesis Lecturer & Special Topics 3 5 S 2002-03 Endocrinol. & Human Reproduction Lecturer 2 200 F 2003-04 Core Course, Proteins Thread Conference Leader 5 12 F 2003-04 Enzymology Lecturer (2 lectures) 3 14 S 2003-04 Endocrinol. & Human Reproduction Lecturer (2 lectures) 2 200 F 2004-05 Enzymology Lecturer (2 lectures) 3 4 F 2004-05 Small Molecule Structure Elucidation Lecturer (2 lectures) 3 2 F 2005-06 Enzymology Lecturer (2 lectures) 3 16 POSTGRADUATE COURSES SPONSORED BY UCSF or UTSW 1999 Advances in Endocrinology and Metabolism: Course Lecturer and Panel Discussant 2001 Update in Internal Medicine: Course Lecturer 2002 Hypertension for Spanish Specialists: Course Lecturer x2 2002 Update in Internal Medicine: Moderator, Endocrinology Section 2003 Update in Internal Medicine: Course Lecturer 2004 Update in Internal Medicine: Course Lecturer 2005 Drug Metabolism and Drug-Drug Interactions: Coursemaster & Lecturer INFORMAL TEACHING: 1995-99 Pediatric Endocrinology Rounds, Clinics, and Conferences Participant 1996-99 Endocrinology Clinical Conference Participant 1997-99 SFGH Endocrinology Clinics and Weekly Conference Staff/Participant 1999-now UT Southwestern Endocrinology & Repro. Endocrinology Conferences Staff/Participant OTHER: 1986-87 Pharmacology Mini-Course "Rational Design of Enzyme Inhibitors" Washington U 1993 Introduction to Molecular Techniques in Endocrinology UTHSCSA 2000-now Co-organizer of Endocrinology Fellows’ Core Curriculum UT Southwestern PAST AND PRESENT TRAINEES: 1994-95 Richard K. Shewbridge (endocrinology fellow) currently private practice, Medina, OH 1996-98 Tim C. Lee (research year prior to matriculating at Tufts Univ. Medical School; also summer between first and second years); currently general pediatrician; awarded Society for Pediatric
    • Research Student Research Fellowship and Endocrine Society Summer Research Fellowship; recipient of 1999 Medical Student Research Award, Society for Pediatric Research 2000 Kavita Vyas, summer student (UTSW-SUMR), currently MS-3 at Columbia Univ.; awarded Best Poster Prize at the 39th Medical Student Research Forum, UT Southwestern 2000-now Manisha Gupta, postdoctoral associate 2000-01 Marivania Costa-Santos, postdoctoral associate, currently physician, Sao Paulo, Brazil 2001-now Daniel Sherbet, summer student, 4th year medical student at UTSW; awarded Best Oral Presentation Prize at the 40th Medical Student Research Forum, UT Southwestern; HHMI Medical Student Fellow 2004-2005 2001 Kristen Bruce, summer student (UTSW-SUMR), currently dental student 2001-2003 Naveed Khan-Sabir, UTSW Repro Endo Fellow, currently reproductive endocrinologist 2003-now Jacqueline Naffin, postdoctoral associate 2003 Siayareh Rambally, summer student, currently 3rd year medical student, UTSW 2003 David Stidd, summer student, currently 3rd year medical student, UTSW 2003 Andrew Brandmeier, summer student (UTSW-SURF), MSTP Student, Indiana Univ. 2003-now Shruthi Krishnan, Biological Chemistry Program graduate student, UTSW 2004 Christopher Dwyer, summer student (UTSW-SURF), currently junior, Davidson Coll. 2004-now Kamalesh Sharma, postdoctoral associate 2005 Neema Chokshi, summer student, currently 2nd year medical student, UTSW 2005 Sarita Singeetham, summer student, currently 2nd year medical student, UTSW 2005-now Alice Chang, UTSW Clinical Scholar RESEARCH AND CREATIVE ACTIVITY: ORIGINAL ARTICLES: 1981 R.L. Danheiser, C.E. Martinez-Davila, R.J. Auchus, and J.T. Kadonaga. A stereoselective synthesis of cyclopentene derivatives from 1,3-dienes. J Am Chem Soc 103: 2443-2446. 1984 H. Liu, R. Auchus, and C.T. Walsh. Stereochemical studies on the reactions catalyzed by the PLP- dependent enzyme 1-aminocyclopropane-1-carboxylate deaminase. J Am Chem Soc 106: 5335-5348. 1985 R.J. Auchus, D.B. Wilson, D.F. Covey, and P.W. Majerus. The 5-hydroxyl of myo-inositol is essential for uptake into HSDM1C1 mouse fibrosarcoma cells. Biochem Biophys Res Comm 130: 1139-1145. 1986 J.A. Shayman, R.J. Auchus, and A.R. Morrison. Bradykinin-induced changes in myo-inositol 1,2- (cyclic)phosphate in rabbit papillary collecting tubule cells. Biochem Biophys Acta 888: 171-175. 1986 R.J. Auchus and D.F. Covey. Mechanism-based inactivation of 17β, 20α-hydroxysteroid dehydrogenase by an acetylenic secoestradiol. Biochemistry 25: 7295-7300. 1987 R.J. Auchus and D.F. Covey. Dehydrogenase inactivation by an enzyme-generated acetylenic ketone: identification of a lysyl enaminone by 13C NMR. J Am Chem Soc 109: 280-282. 1987 R.J. Auchus, S.L. Kaiser, and P.W. Majerus. Synthesis of inositol (1,2-cyclic)-4,5-trisphosphate. Proc Natl Acad Sci USA 84: 1206-1209. 1987 R.J. Auchus, A. D'Avignon, and D. F. Covey. A rare example of extremely strong carbon-carbon coupling: Analysis of 13C- and 1H-NMR spectra of a 13C2- acetylenic ketone. Magn Reson Chem 25: 462-465. 1988 R.J. Auchus, V. Bork, J. Schaefer, and D.F. Covey. Solid state NMR observation of cysteine and lysine Michael adducts of inactivated estradiol dehydrogenase. J Biol Chem 263: 11640-11645. 1989 R.J. Auchus, J.O. Palmer, H.L. Carrell, and D.F. Covey. An efficient conversion of estrone to novel D-norestratrienes, inhibitors of estrogen biosynthesis. Steroids 53: 77-96.
    • 1993 S.A.W. Fuqua, D.C. Allred, and R.J. Auchus. Expression of estrogen receptor variants. J Cell Biochem (Suppl.) 17G: 194-197. 1994 R.J. Auchus, G. Mastorakos, T.C. Friedman, and G.P. Chrousos. Corticotropin-releasing hormone production by a small cell lung carcinoma in a patient with ACTH-dependent Cushing's syndrome. J Endocrinol Invest 17: 447-452. 1994 R.J. Auchus and S.C. Lynch. Treatment of post-orchiectomy gynecomastia with testolactone. The Endocrinologist 4: 429-432. 1994 R.J. Auchus and S.A.W. Fuqua. Prognostic factors and variant estrogen receptor mRNA in clinical breast cancer. Nuclear Medicine and Biology 21: 449-454. 1994 R.J. Auchus and S.A.W. Fuqua. Clinical syndromes of hormone receptor mutations: hormone resistance and independence. Semin Cell Biol 5: 127-136. 1994 R.J. Auchus and S.A.W. Fuqua. Estrogen receptor. IN: Balliere's Clinical Endocrinology, edited by M.C. Sheppard and P.M. Stewart. London: Balliere-Tindall LTD, 8:(2) 433, 449. 1995 C.L. Clarke, R.L. Balleine, R.J. Auchus, and S.A.W. Fuqua. Estrogen and progesterone receptor variants in human breast cancer. Curr Opin Endocrinol Diabetes 2: 398-403. 1997 W.L. Miller, R.J. Auchus, and D.H. Geller. Regulation of 17,20 lyase activity. Steroids 62:133-142. 1997 R.J. Auchus, R.K. Shewbridge, and M.D. Shepherd. Which patients benefit from provocative adrenal testing after transsphenoidal pituitary surgery? Clin Endocrinol (Oxf.) 46:21-27. 1997 D.H. Geller, R.J. Auchus, B.B. Mendonca, and W.L. Miller. The genetic and functional basis of isolated 17,20 lyase deficiency. Nature Genet 17: 201-205. 1998 R.J. Auchus, T.C. Lee, and W.L. Miller. Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer. J Biol Chem 273:3158-3165. 1998 R.J. Auchus, D.H. Geller, T.C. Lee, and W.L. Miller. The regulation of human P450c17 activity: relationship to premature adrenarche and the polycystic ovary syndrome. Trends Endocrinol Metab 9:47-50. 1998 W.L. Miller, D.H. Geller, and R.J. Auchus. The molecular basis of isolated 17,20-lyase deficiency. Endocr Res 24:817-825. 1998 R.J. Auchus. The use of computational chemistry in the study of sex steroid biosynthesis. Endocr Res 24:541-547. 1999 D.H. Geller, R.J. Auchus, and W.L. Miller. P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450-oxidoreductase and cytochrome b5. Mol Endocrinol 13:167-175. 1999 T.C. Lee, W.L. Miller, and R.J. Auchus. Dexamethasone and medroxyprogesterone acetate are competitive inhibitors of different human steroidogenic enzymes. J Clin Endocrinol Metab 84:2104-2110. 1999 R.J. Auchus and W.L. Miller. Molecular modeling of human P450c17 (17α-hydroxylase/17,20- lyase): insights into reaction mechanisms and effects of mutations Mol Endocrinol 13:1169-1185. 1999 M.M. Grumbach and R.J. Auchus. Estrogen: consequences and implications of human mutations in synthesis and action. J Clin Endocrinol Metab 84:4677-4694. 2000 R.J. Auchus and W.L. Miller. Role of cytochrome b5 in the 17,20-lyase activity of P450c17 (letter). J Clin Endocrinol Metab 85:1346. 2000 J.W.M. Martens, D.H. Geller, W. Arlt, R.J. Auchus, V.S. Ossovskaya, H. Rodriguez, T.D. Tlsty, A. Dunaif, and W. L. Miller. Enzymatic activities of P450c17 stably expressed in fibroblasts from patients with the polycystic ovary syndrome. J Clin Endocrinol Metab 85:4338-4346. 2000 R.J. Auchus, D.H. Geller, T.C. Lee, and K.M. Worthy. The function of P450c17 in androgen excess states. J Pediatr Endocrinol Metab 13 Suppl 5:1271-1275. 2000 R.J. Auchus, K.M. Worthy, D.H. Geller, and W.L. Miller. Probing structural and functional domains of human P450c17. Endocr Res 26:695-703. 2000 A.P. Mathieu, R.J. Auchus, and J-G. LeHoux. Molecular modeling of the hamster adrenal P450C17. Endocr Res 26:723-728.
    • 2001 R.J. Auchus. The Genetics, Pathophysiology, and Management of Human Deficiencies of P450c17. Endocrinol Metab Clin NA 30:101-119. 2001 W. Arlt, R.J. Auchus, and W.L. Miller. Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3β-hydroxysteroid dehydrogenase. J Biol Chem 276:16767-16771. 2001 M.K. Gupta, D.H. Geller, and R.J. Auchus. Pitfalls in characterizing P450c17 mutations associated with isolated 17, 20-lyase deficiency. J Clin Endocrinol Metab 86:4416-4423. 2001 L.B. Lutz, L.M.Cole, M.K. Gupta, K.W. Kwist, R.J. Auchus, and S.R. Hammes. Transcription- independent signaling by androgens through the classical androgen receptor is the dominant mechanism of steroid-induced maturation of Xenopus laevis oocytes. Proc Natl Acad Sci (USA) 98:13728-13733. 2002 A.P. Mathieu, R.J. Auchus, and J-G. LeHoux. Comparison of the hamster and human adrenal P450c17 (17α-hydroxylase/17,20-lyase) using site-directed mutagenesis and molecular modeling. J Steroid Biochem Mol Biol 80:99-107. 2002 W. Arlt, J.W.M. Martens, M. Song, J.T. Wang, R.J. Auchus, and W.L. Miller. Molecular evolution of adrenarche: structural and functional analysis of P450c17 from four primate species. Endocrinology 143:4665-4672. 2002 M.K. Gupta and R.J. Auchus. Towards a unifying mechanism for CYP17 mutations that cause isolated 17, 20-lyase deficiency. Endocr Res 28:443-447. 2003 R.J. Auchus, A.S. Kumar, C.A. Boswell, M.K. Gupta, K. Bruce, N.P. Rath, and D.F. Covey. The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21. Arch Biochem Biophys 409:134-144. 2003 J.D. Wilson, R.J. Auchus, M.W. Leihy, O.L. Guryev, R.W. Estabrook, S. Osborne, G. Shaw, and M.B. Renfree. 5α-Androstane-3α,17β-diol is formed in tammar wallaby pouch young testes by a pathway involving 5α-pregnane-3α,17α-diol-20-one as a key intermediate. Endocrinology 144:575-580. 2003 A.P. Mathieu, J-G. LeHoux, and R.J. Auchus. Molecular dynamics of substrate complexes with hamster P450c17: mechanistic approach to understanding substrate binding and activities. Biochem Biophys Acta 1619:291-300. 2003 R.J. Auchus. Aldo is back: Recent advances and unresolved controversies in hyperaldosteronism. Curr Opin Nephrol Hypertens 12:153-158. 2003 C. E. Flück, W.L. Miller, and R.J. Auchus. The 17, 20-lyase activity of cytochrome P450c17 from human fetal testis favors the ∆5 steroidogenic pathway. J Clin Endocrinol Metab 88:3762-3766. 2003 A.K. Agarwal, J-P Fryns, R.J. Auchus, and A. Garg. ZMPSTE24 is mutated in mandibuloacral dysplasia. Hum Mol Genet 12:1995-2001. 2003 M.K. Gupta, O.L. Guryev, and R.J. Auchus. 5α-Reduced, C21 steroids are substrates for human CYP17. Arch Biochem Biophys 418:151-160. 2003 D.P. Sherbet, D. Tiosano, K.M. Kwist, Z. Hochberg, and R.J. Auchus. CYP17 mutation E305G causes isolated 17, 20-lyase deficiency by selectively altering substrate binding. J Biol Chem 278:48563-48569. 2004 M. Costa-Santos, C.E. Kater, and R.J. Auchus. Seven novel CYP17 gene mutations in 24 Brazilian patients with 17-hydroxylase deficiency include two highly prevalent mutations that suggest independent founder effects. J Clin Endocrinol Metab 89:49-60. 2004 M. Costa-Santos, C.E. Kater, E.P. Dias, and R.J. Auchus. Two intronic mutations cause 17- hydroxylase deficiency by disrupting splice acceptor sites: direct demonstration of aberrant splicing and absent enzyme activity by expression of the entire CYP17 gene in HEK-293 cells. J Clin Endocrinol Metab 89:43-48. 2004 R.J. Auchus and W.E. Rainey. . Assembling the pieces of the adrenarche puzzle, from biochemistry and cell biology to human physiology and disease. Clin Endocrinol (Oxf) 60:288-296.
    • 2004 M. Manhendroo, J.D. Wilson, J.A. Richardson, and R.J. Auchus. Steroid 5α-reductase isoenzyme 1 promotes formation of 5α-androstane-3α,17β-diol in the Leydig cell of immature mouse testes by two pathways. Mol Cell Endocrinol 222:113-120. 2004 N. Khan, K.K. Sharma, S. Andersson, and R.J. Auchus. Human 17β-hydroxysteroid dehydrogenases types 1, 2, and 3 catalyze bi-directional equilibrium reactions, rather than unidirectional metabolism, in HEK-293 cells. Arch Biochem Biophys 429:50-59. 2004 R.J. Auchus. The backdoor pathway to dihydrotestosterone. Trends Endocrinol Metab 15:432-438. 2004 R.J. Auchus. Overview of DHEA Biosynthesis. Semn Reprod Med 22:281-288. 2004 J.C. Havelock, R.J. Auchus, and W.R. Rainey. The rise in adrenal androgen biosynthesis: Adrenarche. Semn Reprod Med 22:337-348. 2004 R.J. Auchus. The riddle of adrenarche: many questions, not enough answers. The Endocrinologist 14:329-336. 2005 A.K. Agarwal and R.J. Auchus. Cellular Redox State Regulates Hydroxysteroid Dehydrogenase Activity and Intracellular Hormone Potency. Endocrinology 146:2531-2538. 2005 J.D. Wilson, G. Shaw, M.B. Renfree, R.J. Auchus, M.W. Leihy, and D.C. Eckery. The ontogeny and pathway of formation of 5α-androstane-3α,17β-diol in the testes of the immature brushtail possum Trichosurus vulpecula. Reprod Fert Dev 17:603-609. 2005 K.K. Sharma, A. Lindqvist, J. Zhou, R.J. Auchus, T.M. Penning, and S. Andersson. Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues. Mol Cell Endocrinol (in press). 2005 J. Hollier, D.F. Martin, D. Bell, J-L. Li, M.G. Chirachanchai, D.V. Menon, D. Leonard, R.G. Victor, R.S. Cooper, and R.J. Auchus. Sodium channel allele T594M does not predict blood pressure or response to amiloride in Blacks. (in press). 2005 Naffin-Olivos, J.N., Auchus, R.J. Human Cytochrome b5 Requires Residues E48 and E49 to Stimulate the 17, 20-Lyase Activity of Cytochrome P450c17 (in press). 2005 Papari-Zareei, M., Brandmaier, A., Auchus, R.J. Arginine 276 Controls the Directional Preference of AKR1C9 (Rat Liver 3α-Hydroxysteroid Dehydrogenase) in HEK-293 Cells (in press). 2005 Shaw, G., Fenelon, J., Sichlau, M., Auchus, R.J., Wilson, J.D., and Renfree, M.B. Role of the alternate pathway of dihydrotestosterone formation in virilization of the Wolffian ducts of the tammar wallaby, Macropus eugenii (submitted). BOOK CHAPTERS: 1994 R.J. Auchus. Pituitary and Hirsutism Chapters. IN: Endocrine and Metabolic Testing Manual, 2nd edition, edited by R.F. Dons. Boca Raton: CRC Press (manual chapters). 1997 R.J. Auchus. Pituitary, Endocrine Diagnosis by Molecular Biologic Procedures, Gonadal and Reproductive, and Thyroid Chapters. IN: Endocrine and Metabolic Testing Manual, 3rd edition, edited by R.F. Dons. Boca Raton: CRC Press (manual chapters). 1997 D.H. Geller, R.J. Auchus, and W.L. Miller. The role of P450c17 in androgen biosynthesis. IN: Androgen Excess Disorders in Women, edited by R. Azziz, J.E. Nestler, and D. Dewailly. New York: Lipincott-Raven, pp. 315-325. 2000 W.L. Miller and R.J. Auchus. Biochemistry and genetics of human P450c17. IN: Adrenal Disease in Childhood: Clinical and Molecular Aspects, edited by I.A. Hughes and A.J.L. Clark. Basel: Karger 2: 63-92. 2001 R.J. Auchus and W.L. Miller. The principles, pathways, and enzymes of human steroidogenesis. IN: Endocrinology, 4th edition, edited by L.J. DeGroot. Philadelphia: W.B. Saunders, pp. 1616-1631. 2002 R.J. Auchus and W.L. Miller. Human 17α-hydroxylase/17, 20-lyase. IN: Genetics of Steroid Biosynthesis and Function, edited by J.I. Mason. Reading UK: Harwood Academic Publishers, pp. 259-286.
    • 2003 R.J. Auchus. Adrenal Cortex, Cushing Syndrome, Cushing Disease, and Addison’s Disease sections. IN: Encyclopedia of Neurological Sciences, 1st edition, edited by M.J. Aminoff and R.B. Daroff. San Diego: Academic Press pp. 39-40, 43-45,806-808, 808-809. 2004 R.J. Auchus. Assessment of Endocrine Function. IN: Textbook of Endocrine Physiology, 5th edition, edited by J.E. Griffin and S.R. Ojeda. Oxford: Oxford University Press pp.101-119. 2004 R.J. Auchus and W.L. Miller. 17α-Hydroxylase/17, 20-lyase deficiency. IN: Encyclopedia of Endocrinology and Endocrine Diseases, 1st edition, edited by L. Martini. San Diego: Academic Press pp. 153-162. 2004 M.R. Vanderwel and R.J. Auchus. Androgen biosynthesis and gene defects. IN: Encyclopedia of Endocrinology and Endocrine Diseases, 1st edition, edited by L. Martini. San Diego: Academic Press pp. 201-210. 2005 R.J. Auchus and W.L. Miller. The principles, pathways, and enzymes of human steroidogenesis. IN: Endocrinology, 5th edition, edited by L.J. DeGroot. Philadelphia: W.B. Saunders, pp. 2263-2285. 2005 R.J. Auchus and C.M. Adams. Cholesterol, steroid, and isoprenoid biosynthesis. IN: Encyclopedia of Life Sciences, 2nd edition. London: Macmillan Reference Ltd. doi: 10.1038/npg.els.0001393. 2005 R.J. Auchus, W.E. Rainey, and K.L. Parker. Adrenal diseases. IN: Principles of Molecular Medicine, 2nd edition. Totowa: Humana Press, Inc. (in press). 2005 D.P. Sherbet and R.J. Auchus, Peripheral Testosterone Metabolism. IN: Leydig Cell in Health and Disease, 3rd edition, edited by A. Payne and M. Hardy, (in press). ABSTRACTS: 1980 R.L. Danheiser, C.E. Martinez-Davila, J.T. Kadonaga, and R.J. Auchus. Sterioselective synthesis of cyclopentenone derivatives from 1,3-dienes. Proceedings of the 186th National American Chemical Society Meeting, Atlanta, GA. 1986 R.J. Auchus and D.F. Covey. Synthesis and evaluation of 14,15-secoestra-15-ynes, inhibitors of estradiol dehydrogenase from human term placenta. Proceedings of the 192nd National American Chemical Society Meeting, Anaheim, CA. 1993 R.J. Auchus, D.C. Allred, C.K. Osborne, and S.A.W. Fuqua. Loss of PgR in metastases from ER+/PgR+ primary breast carcinomas is not due to alterations in ER mRNA. Endocrinol Suppl 134:526, Abst 1904. 1993 D.G. Martinez, R.J. Auchus, and T.F. Saad. Determining urea distribution volume by dual-energy X- ray absorptiometry (DEXA). J Am Soc Nephrol 4: 320. 1993 R.J. Auchus, M. Qui, G. Clark, C.K. Osborne, and S.A.W. Fuqua. Expression of estrogen receptor variant transcripts in metastatic breast cancers. Breast Cancer Res Treat 27: 164. 1995 R.K. Shewbridge, M.D. Shepherd, and R.J. Auchus. Serum cortisol after pituitary surgery predicts the subsequent response to insulin tolerance testing and the need for postoperative glucocorticoid therapy. Endocrinol Suppl 136:484, Abst P3-61. 1995 R.J. Auchus, M.J. McPhaul, and S.A.W. Fuqua. Characterization of a novel androgen receptor mutation in the amino terminal portion of the hormone binding domain from a kindred with complete androgen insensitivity. Endocrinol Suppl 136:239, Abst P1-508. 1996 R.J. Auchus, S. Graham-Lorence, J.A. Peterson, and W.L. Miller. A second-generation molecular graphics model of human P450c17 based on assembly of core structural elements. Proceedings of the 2nd International Symposium on Molecular Steroidogenesis, Monterey, CA. 1997 D.H. Geller, R.J. Auchus, B.B. Mendonca, and W.L. Miller. Molecular mechanism of 17,20 lyase deficiency. 15th Joint Meeting of the European Society for Pediatric Endocrinology and the Lawson Wilkins Pediatric Endocrine Society, Stockholm, Sweden. Hormone Res 48 (Suppl 2):12 (Abst #47). 1997 R.J. Auchus, T.C. Lee, D.H. Geller, and W.L. Miller. P450-oxidoreductase, but not cytochrome b5, confers 17, 20-lyase activity to human P450c17 in yeast. Endocrinol Suppl 138:102, Abst OR26-5.
    • 1997 R.J. Auchus and W.L. Miller. The molecular mechanisms that regulate 17,20-lyase activity: the rise and fall of DHEA. Annual Meeting for the Predoctoral and Postdoctoral Fellows of the Howard Hughes Medical Institute, Chevy Chase, MD. 1997 R.J. Auchus, D.H. Geller, and W.L. Miller. Computer modeling of P450c17 predicts functional consequences of human mutations. FASEB J 11:A795, Abst P138. 1998 R.J. Auchus and W.L. Miller. Computer modeling of human P450c17. Proceedings of the 8th Adrenal Cortex Conference:41. 1998 D.H. Geller, R.J. Auchus, and W.L. Miller. Enzymologic defect in the R347H and R358Q mutations in P450c17 that cause selective 17,20-lyase deficiency. Pediatr Res 43:75A, Abst 425. 1998 R.J. Auchus and W.L. Miller. A heuristic molecular model of human P450c17. Endocrinol Suppl 139:181, Abst P1-290. 1999 T.C. Lee, W.L. Miller, and R.J. Auchus. Medroxyprogesterone Acetate (MPA) Inhibits pituitary- independent steroidogenesis by inhibiting 3β-hydroxysteroid dehydrogenase type II. Pediatr Res 45:93A, Abst 537. 1999 T.C. Lee, W.L. Miller, and R.J. Auchus. Targets and potencies of medroxyprogesterone acetate (MPA) and Dexamethasone (Dex) as inhibitors of human steroidogenic enzymes. Endocrinol Suppl 140:541, Abst P3-480. 2000 R.J. Auchus, K. Worthy, and W.L. Miller. Probing structural and functional domains of human P450c17. Proceedings of the 9th Adrenal Cortex Conference. No. 8. 2000 J.W.M. Martens, D.H. Geller, V.S. Ossovskaya, R.J. Auchus, W. Arlt, A. Dunaif, and W. L. Miller. 17,20-Lyase activity in cultured fibroblasts stably expressing P450c17: no difference between patients with polycystic ovary syndrome and normal subjects. Endocrinol Suppl 141:404, Abst 1671. 2001 R.J. Auchus, M.K. Gupta, K.M. Kwist, and K.M. Vyas. Stucture-function studies of human P450s –c17 and –c21. Proceedings of the First Southwest P450 Meeting:15, Abst L6. 2001 M.K. Gupta, D.H. Geller, and R.J. Auchus. P450c17 mutation F417C does not cause isolated 17, 20- lyase deficiency. Proceedings of the First Southwest P450 Meeting:31, Abst P8. 2001 M. Costa-Santos, C.E. Kater, and R.J. Auchus. Clinical and molecular genetic studies of 18 Brazilian families with 17-hydroxylase deficiency (17OHD). Proceedings of the First Southwest P450 Meeting:36, Abst P13. 2001 R.J. Auchus, K.M. Vyas, K.W. Kwist, M.K. Gupta, and W.L. Miller. Biochemistry of cytochrome b5·P450c17 fusion proteins. Endocrinol Suppl 142:123, Abst OR41-1. 2001 M. Costa-Santos, C.E. Kater, and R.J. Auchus. Clinical and molecular genetic studies of 18 Brazilian families affected by 17-OH-deficiency. Endocrinol Suppl 142:123, Abst OR30-3. 2001 M.K. Gupta, D.H. Geller, and R.J. Auchus. P450c17 Mutation F417C cannot by itself cause isolated 17, 20-lyase deficiency. Endocrinol Suppl 142:295, Abst P2-2. 2001 W. Arlt, R.J. Auchus, and W.L. Miller. Thiazolidinediones but not metformin directly inhibit 17α- hydroxylase, 17, 20-lyase, and 3β-hydroxysteroid dehydrogenase activities in human androgen biosynthesis. Endocrinol Suppl 142:295, Abst P2-3. 2001 W. Arlt, R.J. Auchus, and W.L. Miller. Thiazolidinediones but not metformin directly inhibit 17α- hydroxylase, 17, 20-lyase, and 3β-hydroxysteroid dehydrogenase activities in human androgen biosynthesis. Pediatr Res 49:54A, Abst 222. 2001 R.J. Auchus, M.K. Gupta, K.M. Kwist. Blending computational and biochemical approaches to study the activities of human P450c17 and P450c21. Proceedings of the 12th International Conference on Cytochrome P450:51, Abst CL8-2. 2002 R.J. Auchus. The science of androgen abuse (Minicourse C), Proceedings of the National Athletic Trainers’ Association 53rd Annual Meeting and Clinical Symposia, 230-233. 2002 R.J. Auchus, D. Sherbet, M.K. Gupta, K.W. Kwist, O. Guryev, R.W. Estabrook, M. Costa-Santos, C.E. Kater, D. Tiosano, I. Koren, Z. Hochberg. Expanding the spectrum of diseases and activities of CYP17. Proceedings of the 10th Adrenal Cortex Conference. No. 5.
    • 2002 D. Sherbet, D. Tisano, I. Koren, Z. Hochberg, and R.J. Auchus. CYP17 mutation E305G is devoid of ∆5 lyase activity but has increased ∆4 lyase activity: genetic proof that the ∆4 pathway is insufficient for complete formation of the male phenotype. Endocrinol Suppl 143:149, Abst OR62-5. 2002 L.B. Lutz, L.M. Cole, M.K. Gupta, K.W. Kwist, R.J. Auchus, and S.R. Hammes. Androgen signaling through the classical androgen receptor may be the dominant mechanism of steroid- induced maturation in Xenopus laevis oocytes. Endocrinol Suppl 143:257, Abst P1-442. 2002 N.M. Khan-Sabir, K. Bruce, and R.J. Auchus. Human 17β-hydroxysteroid dehydrogenase type 1 catalyzes the fully reversible interconversion of estrone and estradiol at equal rates in HEK-293 cells. Endocrinol Suppl 143:275, Abst P1-523. 2002 M.K. Gupta, O.L. Guryev, and R.J. Auchus. 5α-Reduced, C21 steroids are efficiently metabolized to dihydrotestosterone precursors by human CYP17. Endocrinol Suppl 143:276, Abst P1-527. 2002 P.C. Gagliardi, L. Buckloh, A. Lindqvist, N.M. Khan-Sabir, R.J. Auchus, and S. Andersson. A novel mutation in the HSD17B3 Gene in a patient with 17β-hydroxysteroid dehydrogenase deficiency transiently managed with GnRH analog. Endocrinol Suppl 143:487, Abst P2-712. 2002 M. Costa-Santos, C.E. Kater, K.W. Kwist, and R.J. Auchus. Two intronic mutations in the CYP17 gene cause 17-hydroxylase deficiency by inactivating splice acceptor site. Endocrinol Suppl 143:600, Abst P3-464. 2002 N.M. Khan-Sabir and R.J. Auchus. Human 17β-hydroxysteroid dehydrogenase type 2 reversibly interconverts androgens and estrogens at equal rates in vivo. Fert Ster Suppl 1 78: S281. 2003 R.J. Auchus, M.K. Gupta, M. Santos, D.P. Sherbet, O.L. Guryev, and J.D. Wilson. New functions and pathways for CYP17. Proceedings of the Third Southwest P450 Meeting:17. 2003 M.K. Gupta, K. Xu, and R.J. Auchus. Mapping active site geometry of human CYP21 with computer modeling and site-directed mutagenesis. Endocrinol Suppl 144:91, Abst OR23-4. 2003 C.E. Flück, W.L. Miller, and R.J. Auchus. Human fetal testis produces testosterone predominantly through the ∆5 steroidogenic pathway. Presented at ESPE2003. 2003 D.F. Martin, D.S. Leonard, R.J. Auchus, R.G. Victor. Lack of association between ENaC T594M polymorphism and hypertension in an African American random population. Circulation 108: 3229 Suppl. S. 2004 R.J. Auchus, J.D. Wilson, M. Mahendroo, J.D. Richardson. Testicular 5α-androstane-3α,17β-diol synthesis in the tammar wallaby and mouse predominantly derive from different pathways. Endocrinol Suppl 145:130, Abst OR39-2. 2004 J.L. Naffin and R.J. Auchus. Identifying residues on cytochrome b5 that stimulate the 17,20-lyase activity of human cytochrome P450c17. Endocrinol Suppl 145:131, Abst OR39-5. 2005 B. Miller, R. Auchus, B. Dolmatch, L. Watumull, S. Burkey, T. Anthony, F. Nwariaku. Limitations of CT scans as a predictor of hormone hypersecretion in primary hyperaldosteronism. Accepted for presentation at the Association of VA Surgeons 29th Scientific Sympostium, Salt Lake City. 2005 R.J. Auchus. Emerging Phenotypes in 17-Hydroxylase Deficiency. Endocrinol Suppl 146:53, Abst S48-2. 2005 D.P. Sherbet and R.J. Auchus. Human 17β-hydroxysteroid dehydrogenase type 2 (17βHSD2) retains strict oxidative preference despite mutagenesis and chimerism that favor reduction. Endocrinol Suppl 146:428, Abst P2-296. 2005 R.J. Auchus, M. Papari-Zareei, and A. Brandmaier. Arginine 276 controls the reductive preference of AKR1C9 (rat liver 3α-hydroxysteroid dehydrogenase) in intact cells. Endocrinol Suppl 146:429, Abst P2-302. 2005 M.K. Gupta and R.J. Auchus. Re-Engineering the chemistry of human CYP21 with active site mutagenesis. Proceedings of the 14th International Conference on Cytochrome P450:138, Abst P.C4. 2005 J.L. Naffin and R.J. Auchus. Mutagenesis of cytochrome b5 dissociates electron transfer properties from allosteric stimulation of 17,20-lyase activity. Proceedings of the 14th International Conference on Cytochrome P450:152, Abst P.P5.
    • 2005 J.L. Li, J. Hollier, D.F. Martin, D. Bell, D. Leonard, R.J. Auchus, R.J. Victor. Are alpha-2 adrenergic receptor polymorphisms associated with human hypertension? FASEB J. 19: A1610, Part 2, Suppl. S. OTHER PUBLICATIONS: 1981 Impacts of Applied Genetics. Washington DC: U.S. Office of Technology Assessment (contributor). 1990 R.J. Auchus. A syringe for a stick. contribution to "Tricks of the Trade" column in Emergency Medicine. issue of October 30, 1990. PATENT DF Covey and RJ Auchus. Open 'D'-Ring Hormone Analogs, #4,874,891. Filed April 30, 1986; Issued October 17, 1989. FUNDING: TOTAL DIRECT COSTS AWARDED: PREVIOUS FUNDING 1982-87 Washington University Training Grants: MSTP 5T32 GM07200 8/15/82-6/30/88 and Molecular, Biochemical, and Physiological Pharmacology 5T32 GM07805 6/1/85-5/31/87 5 years, $29,000 1987-88 Olin Fellowship, Washington University Division of Biology and Biomedical Sciences 1 year, $7,000 1994-95 Wilford Hall Medical Center, Institutional Research Grant 1 year, $2,000 1995-96 Howard Hughes Medical Institute Postdoctoral Physician Fellowship 1 year, $79,000 (terminated after year 1 of 3 to enable acceptance of K08 DK02387) 1999-2001 NIH Small Grant, Supplement to Clinical Investigator Award 1 R03 DK56641 2 years, $100,000 1996-2002 NIH Clinical Investigator Award 1 K08 DK02387 5 years, $496,900 2001-2004 Welch Foundation Grant I-1493 3 years, $150,000 PRESENT FUNDING 2004-2007 Welch Foundation Grant I-1493, PI 3 years, $150,000 2003-2005 NIH Pilot and Feasibility Study, R21 DK059942, PI 2 years, $200,000 2003-2008 NIH Program Project, RR19484 (M.I. New, PI), Investigator 5 years, $5,846,480 2004-2006 Donald W. Reynolds Cardiovascular Clinical Research Center, Associate 2 years, $12,000,000 PENDING FUNDING 2006-2011 Burroughs Wellcome Clinical Scientist Award, pending review 5 years, $750,000
    • 2006-2008 March of Dimes Research Grant, pending review 3 years, $240,000 2006-2011 NIH R01 DK073144, pending review 5 years, $1,125,000 SUMMARY OF TEACHING DUTIES: Total hours of teaching during the past academic year 60 Total hours of teaching during current academic year 60 Total hours of teaching next academic year (anticipated) 60 FIVE MOST RECENT SIGNIFICANT PUBLICATIONS: 2004 M. Costa-Santos, C.E. Kater, and R.J. Auchus. Seven novel CYP17 gene mutations in 24 Brazilian patients with 17-hydroxylase deficiency include two highly prevalent mutations that suggest independent founder effects. J Clin Endocrinol Metab 89:49-60. 2004 N. Khan, K.K. Sharma, S. Andersson, and R.J. Auchus. Human 17β-hydroxysteroid dehydrogenases types 1, 2, and 3 catalyze bi-directional equilibrium reactions, rather than unidirectional metabolism, in HEK-293 cells. Arch Biochem Biophys 429:50-59. 2005 J. Hollier, D.F. Martin, D. Bell, J-L. Li, M.G. Chirachanchai, D.V. Menon, D. Leonard, R.G. Victor, R.S. Cooper, and R.J. Auchus. Sodium channel allele T594M does not predict blood pressure or response to amiloride in Blacks. (in press). 2005 Naffin-Olivos, J.N., Auchus, R.J. Human Cytochrome b5 Requires Residues E48 and E49 to Stimulate the 17, 20-Lyase Activity of Cytochrome P450c17 (in press). 2005 Papari-Zareei, M., Brandmaier, A., Auchus, R.J. Arginine 276 Controls the Directional Preference of AKR1C9 (Rat Liver 3α-Hydroxysteroid Dehydrogenase) in HEK-293 Cells (in press).