CLINICAL RESEARCH FELLOW
(DIABETES AND ENDOCRINOLOGY)
Job Ref: R-571117
School: Clinical Science Division: Diabetes and Endocrinology
Salary: Depending on qualifications and experience Range: £30,685 - £38,911 pa
Location: University Hospital Aintree Hours of work: Full time
Tenure: Up to 2 years Closing Date: 7 December 2009
Interview Date: 16 December 2009
Informal enquiries to Dr Christina Daousi on 0151 529 5920, email: email@example.com
Applications should comprise:
*A completed applicant information form
* A copy of your full curriculum vitae
*A statement indicating the reasons for applying for this post and how your training and experience is relevant.
If you have any particular requirements should you be invited to interview, please make this clear in
Applications may be submitted by e-mail to firstname.lastname@example.org or by post or in person to: The Director of Human
Resources (Recruitment), The University of Liverpool, Hart Building, Mount Pleasant, Liverpool L3 5TQ
ROYAL MAIL – Postal Pricing System. Please ensure that postal applications carry the correct postage according to the weight and
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Acknowledgement of Applications
Please note that we are unable to acknowledge postal applications. If you would like an acknowledgement
please enclose a stamped addressed card or envelope, and place it at the front of your application. If you e-mail
your application you will receive an automated acknowledgement.
Shortlisting and Interviews
Shortlisting and interview arrangements are the responsibility of the recruiting Department. Please contact Dr
Christina Daousi on 0151 529 5920 if you have a query after the closing date.
Outcome of Applications
Vacancies at the University often attract a large number of candidates and it is not always possible to respond
individually to every application. If you have not heard from the recruiting Department by mid December 2009
please take it that your application has not been successful.
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Asylum & Immigration
The University will comply with the Immigration, Asylum and Nationality Act 2006, which requires all employees to
provide documentary evidence of their legal right to work in this country prior to commencing employment.
Candidates will be required to bring their passport (and visa if applicable) to interview so that it can be copied and
verified by a member of the Selection Panel. For posts requiring a recognised degree level or equivalent
qualification, and where there is no suitable UK or European Economic Area candidate, the University will take the
necessary steps to secure UK Border Agency permission for a foreign national to take up employment.
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website at: www.ukba.homeoffice.gov.uk/pointscalculator
A candidate may also be required to undertake an English Language test prior to commencing work at the
University. Details of Home Office approved tests can be found at:
Further information on the eligibility criteria for Certificates of Sponsorship can be found at:
Diversity and Equality
The University of Liverpool is committed to diversity and equality of opportunity. All employees and applicants
for jobs will be considered on their abilities and will not be discriminated against on the grounds of age, caring
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consider them on their abilities.
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If you have any other requirements which will help you access the application or interview process or
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Resources Department website www.liv.ac.uk/hr
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This post is being funded by the NovoNordisk UK Research Foundation (an NIHR partner) and
would be suitable for a candidate pursuing a career in Diabetes & Endocrinology, who intends to spend
more time in research, with the aim of achieving a higher degree (MD). You will be expected to have
experience in the speciality, either at Senior House Officer or Registrar/ST level; research experience
(for example as an academic F2) would be an advantage. Membership of the Royal College of
Physicians (UK) or equivalent qualifications would be desirable. You should be fully registered with the
General Medical Council. You will be based at University Hospital Aintree in Liverpool and will be a
member of the Diabetes & Endocrinology Directorate, within the Clinical Research Group.
The North West Strategic Health Authority was formed from the amalgamation of the Mersey, North
Western and part of the Northern RHAs and has a population of 6.6million.
Merseyside itself consists of 5 metropolitan boroughs, the largest being the City of Liverpool. Sefton
Metropolitan Borough is contiguous and stretches along the coastal strip north of the River Mersey as
far as Southport. The Sefton population is served by two main Hospital complexes, namely Aintree
Hospitals, serving South Sefton, and Southport and Formby District General Hospitals serving the
There are 294,000 residents living within the geographical boundaries of Sefton Health Authority and
around 175,000 in the southern part of the area. The figure is expected to decline slightly but within
this overall decline the elderly population will increase.
Liverpool is a dynamic city. It has experienced a major revival over the past few years and
Merseysiders enjoy a superb quality of life. It is unusually compact and a journey to the centre rarely
takes more than 30 minutes.
The county abounds with fine architecture, lively cultural pursuits and outstanding sport. Tourism has
become a major industry and 20 million people visited the city last year, attracted both by the area’s
natural and man made assets.
Liverpool was the European Capital of Culture for 2008. Merseyside’s theatres, museums and art
collections are now amongst its strongest assets. The city is alive with independent theatre groups,
authors, poets and dance groups. Photography, sculpture, street art and video makers abound. The
Walker Art Gallery contains a collection equal to any in the provinces and the Tate Gallery opened in
1988 on Liverpool’s waterfront in the refurbished Albert Dock.
The Philharmonic Orchestra is nationally acclaimed and there is a full range of musical activities of all
There are both Anglican and Roman Catholic Cathedrals and facilities for worship of every other faith
in the city. There are excellent schools for both sexes, including a variety of denominational schools in
the private and state sector.
The University Medical School is within 20 minutes drive of Aintree Hospitals.
There is very good housing in pleasant suburbs near the sea and in rural areas which is easily
Two airports are within easy reach. Liverpool and Manchester International Airport are within half to
three quarters of an hour’s driving time. There are excellent train services and motorway links to all
parts of the country with easy access to the national parks, North Wales, the Peak District, the Lake
District, as well as to both Lancashire and the North Wales coasts.
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You will normally be required to live within 10 miles of the University Hospital Aintree so as to allow easy
access to the Hospital as required.
University Hospital Aintree
The University Hospital Aintree is a large teaching hospital for the University. It houses a large
Accident and Emergency Department and most major acute specialties are represented including
General Surgery, ENT, Orthopaedics, Urology, and acute medical services. In addition, there are
specialised units for Diabetes & Endocrinology, Cardiology, Thoracic Medicine, Nephrology,
Rheumatology and Rehabilitation, Gastroenterology, Medicine for the Elderly, Regional Maxillofacial
and Cancer of the Head and Neck and the Younger Disabled Unit. There is a fully equipped 17 bed
Critical Care Unit (General Intensive Care Unit and High Dependency Unit) and a large Cardiac
Intensive Care Unit as well as a dedicated acute Stroke Unit.
It is also the site of the Sub-Regional Public Health Laboratory and there is a large Radiology
Department servicing the Hospital. A Cardiac Catheter Laboratory opened in September 2003.
The Walton Centre for Neurology and Neurosurgery NHS Trust
The Walton Centre is an NHS Trust providing neurology and neurosurgical services to a catchment
population consisting of Merseyside, North Wales, the Isle of Man and part of West Lancashire. The
Centre is a new purpose built Hospital in the grounds of University Hospital Aintree and has 63
Neurosurgical beds, 36 neurology beds, 11 paediatric beds, 4 pain relief beds, ITU and Day-Case Unit.
The Department of Neuroscience of the Faculty of Medicine of the University of Liverpool is based at
the Walton Centre.
Walton Hospital is situated approximately 4 miles from the city centre and 2½ miles from the University
Hospital Aintree, providing Out-patient and Day Case services. The Ophthalmology Directorate is
based on this site.
Education, Teaching and Research
The University Hospital Aintree has a strong commitment to and an excellent reputation for teaching
and research, providing facilities for undergraduate clinical teaching and postgraduate work for the
University with which there is a close relationship. The Trust makes a major contribution to the
teaching and training of medical students and postgraduate doctors.
Strong links with the University have been forged over the past few years to develop the Trust’s
academic base. Five University Professors with duties entirely at University Hospital Aintree have
been appointed. Professor John Wilding, Chair of Medicine and Director of the Diabetes &
Endocrinology Clinical Research Group, Professor Ian MacFarlane, Honorary Chair in Diabetes &
Endocrinology, Professor Geoff Gill, Chair of International Medicine, Professor Peter Calverley Chair in
Rehabilitation Medicine (Respiratory), and Professor Rob Moots, Chair of Rheumatology. These
appointments play a vital part in the Trust’s intention to enhance its academic reputation. Many other
specialties also have academic appointees.
The Trust has an Associate Medical Director - Medical Education (Professor John Earis), an Associate
Medical Director - Research and Development (Professor R J Moots), and an Associate Medical
Director – Clinical Governance (Dr N P Mercer).
A varied programme of lectures and seminars in a wide variety of specialties is organised by the
Postgraduate Centre and these are well supported by Hospital medical staff. There is a monthly
clinical Grand Round and Clinical Audit meetings are held regularly. There is an excellent medical
illustration (photography) department.
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The Clinical Sciences Centre for Research and Education houses the research units and offices of the
University Clinical Departments and those of the Walton Centre for Neurology and Neurosurgery NHS
Trust. In addition, the new building embraces the Directorate of Medical Education, comprising offices,
seminar rooms and undergraduate facilities. The Centre has a Lecture Theatre, with a capacity of 225,
fully equipped with audio visual aids and with the built in facility for video-conferencing. The Centre
has already become a popular venue for a number of national meetings, seminars and symposia.
There is an exhibition hall next to the Lecture Theatre.
The Library and Information Resource Centre, on the first floor, provides a multi-disciplinary service
including reference and lending collections from the School of Health Studies, the Postgraduate and
Walton Centre libraries and includes network and stand-alone electronic information services, including
CD Rom and on-line databases. Client training and support services, including interactive workbooks,
electronic information/self study packages, group training sessions and on screen printing can be
provided. Remote access to the information system is available outside opening hours at designated
locations within the Hospital.
Research in Endocrinology, Diabetes and Obesity at UHA
The Diabetes and Endocrinology Clinical Research Group has its clinical base at the UHA, where
Professor John Wilding directs the Clinical Research Unit (CRU) which is housed in the Clinical
Sciences Centre. The Group is busy and productive and has a large external grant income (>£5 million
since 1998). The Group has an excellent publication output, for which it is recognised at international
External funding has been obtained to equip the clinical physiology laboratories in the Clinical Sciences
Centre for a wide range of metabolic and vascular studies in obesity and diabetes, and molecular and
tissue-culture laboratories are also available in the Centre. Facilities available include those needed
for metabolic studies such as euglycaemic clamps, assessment of metabolic rate, measurements of
vascular function, heart rate variability, baroreflex sensitivity, pulse wave analysis and
microneurography. Currently, the senior members of the Group comprise Professor John Wilding,
Professor Ian MacFarlane, Professor Geoff Gill, Dr Christina Daousi and Dr Daniel Cuthbertson who
supervise clinical research at the Clinical Sciences Centre of UHA. The Group also supervise non-
clinical researchers in the Neuroendocrine and Obesity Research Unit (Neurob), headed by Professor
Paul Trayhurn which is housed in the Department of Medicine at the Royal Liverpool University
Hospital near the main University Campus. Professor Gill has interests in cardiovascular risk in type 2
diabetes, long-term survivors of type 1 diabetes, unstable type 1 diabetes and hypoglycaemia. He also
has an interest in diabetes in the tropics, and has close links with the Liverpool School of Tropical
Staff within the Diabetes & Endocrinology Clinical Research Group supporting research in diabetes and
endocrinology currently comprises a Clinical Lecturer (new appointment pending), four Clinical
Research Fellows, five Research Nurses and a Research Dietician. The main areas of research are
metabolic and vascular studies in obesity and diabetes, translational research into incretin hormones,
hypoglycaemia, non-alcoholic fatty liver disease, PCOS, risk factors in type 2 diabetes and studies in
unstable type 1 diabetes, together with clinical trials of new treatments in diabetes and obesity, adult
growth hormone deficiency and hypothalamic obesity.
The Unit actively collaborates with several other groups on site, including NHS and academic
consultants in Diabetes and Endocrinology, Respiratory Medicine, Neurology and Clinical
The Diabetes and Endocrinology Directorate
The Diabetes and Endocrinology Directorate at Aintree Hospitals serves the local population
(approximately 350,000) and, because of the specialist interests of the consultants, also takes patients
from a much wider catchment area including the North West of England and North Wales. As well as
managing diabetic patients, the existing Consultants provide essential services in related disciplines,
notably endocrinology, obesity and lipid disorders, and also fulfil a substantial General Medical
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The Diabetes Centre at Aintree Hospital was established in 1990 in purpose-built premises at Walton
Hospital. A comprehensive range of out-patient services is provided, with easy access to the multi-
disciplinary diabetes care team. There is a Nurse Consultant in Diabetes/Endocrinology (Maureen
Wallymahmed) and a team of Specialist Nurses (4), Diabetes Educators and Ward Liaison Nurses (4),
Dieticians and Chiropodists. There are also close links with the Ophthalmologists, Vascular Surgeons,
Nephrologists and Endocrine Surgeons.
Daily diabetes clinics and health education sessions are held, with separate clinics for adolescents,
foot problems, CV risk factor management, insulin pump service and pregnant patients with diabetes.
In addition, lipid, endocrinology and obesity clinics are held weekly. Combined neurosurgical-
endocrine clinics are held in The Walton Centre for Neurology & Neurosurgery and close links exist
with the endocrine surgery clinics.
In 2005-6 there were more than 6,000 out-patient attendances at the Diabetes Centre and over 3,000
patients are registered at the Centre. Referrals from outside the usual catchment population are also
In view of the increasingly elderly population in Sefton and the high prevalence (10%) of diabetes in the
over 70s, the demand for diabetes care will undoubtedly continue to increase. It is predicted that the
prevalence of diabetes will double in the next decade. Since its inception, the Aintree Diabetes Centre
has been active in developing links with Primary Care and Community colleagues and there is an
agreed shared-care protocol “Diabetes Care Guidelines” in conjunction with South Sefton and
Liverpool Primary Care Trusts.
The Directorate is responsible for 52 medical beds at University Hospital Aintree on two wards. The
Consultant staff participate in the Medical Directorate “post-take” ward round system which currently
involves 5 teams of physicians (Gastroenterology, Cardiology, DME, Respiratory and
The Consultants working in the Directorate all undertake General Medical duties and have special
interests as follows:
Professor John Wilding (Head of the Diabetes & Endocrinology academic unit)
Obesity and type 2 diabetes
Professor I A MacFarlane
Neuroendocrinology, adolescent diabetes, endocrinology (including MEN syndrome)
Professor Geoffrey Gill
Brittle diabetes, diabetic foot problems, risk factors in type 2 diabetes
Dr S Benbow (Clinical Director)
Community Diabetes Care, diabetic neuropathy, diabetic foot problems
Dr Christina Daousi
Incretin hormones in obesity and diabetes, type 1 diabetes, neuroendocrinology
Dr Daniel Cuthbertson
Diabetes, General Endocrinology, MEN syndrome
Dr I F Casson
Medical Disorders of Pregnancy
Job Ref: R-571117
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The Medical Staff complement for the Directorate is:
Lecturer (SpR) 1
Specialist Registrars 4
Senior House Officers 3
Foundation Yr 2 1
Pre-registration House Officers 3
Dr van Heyningen, Consultant in Clinical Chemistry and the Biochemistry Department Associate
Specialist Dr David Wile also work closely with the directorate in the Lipid Disorders and Diabetes
1. Job Description
The role will undertake research work into the pancreatic and extra-pancreatic effects of the incretin
hormone GIP (glucose-dependent insulinotropic hormone) in humans in health and type 2 diabetes
mellitus. The proposed work is built on existing research interests and is a natural extension of
research carried out recently by one of the supervisors Dr C Daousi. The research unit has experience
in undertaking infusion studies in humans and all the necessary protocols are in place for the proposed
experimental procedures. You will receive the appropriate training for the procedures that will be
employed in your studies. The appointee will be expected to register for a higher degree (MD) and
Dr Daousi and Dr Cuthbertson will be overseeing your work. The Research Fellow will work as a
member of the Diabetes & Endocrinology Clinical Research Group, which has a large external grant
income and also has a longstanding and highly successful track record in clinical research and an
excellent publication output, for which it is recognised at international level. The Diabetes and
Endocrinology Clinical Research Group is part of the University’s School of Clinical Sciences and is
based in the Clinical Sciences Centre at UHA, where Professor John Wilding directs the Clinical
Research Unit. The Research Fellow will have access to the clinical physiology laboratories in the
Clinical Sciences Centre which are appropriately equipped for a wide range of metabolic and vascular
studies in obesity and diabetes; molecular and tissue-culture laboratories are also available in the
Centre. Facilities available include those needed for metabolic studies such as
hyperglycaemic/euglycaemic clamps, assessment of metabolic rate, adipose tissue biopsies,
measurements of vascular function, heart rate variability, baroreflex sensitivity, stable isotope
methodology, pulse wave analysis and microneurography. There are a number of academic workshops
run by the University of Liverpool which the research fellow will be encouraged to attend. These
workshops are designed to help develop a number of other skills and include advanced statistics
workshops and career skills workshops. In addition, the NovoNordisk UK Research Foundation will
provide the Research Fellow with a number of training opportunities and training courses related to
research practice, analysis and presentation of their results, attendance at which is obligatory. The
Research Fellow will also be expected to participate in the medical and scientific meetings of Diabetes
UK at least once a year to present the results emanating from the research project and the Research
Foundation meetings/symposiums. Expenses will be provided.
The sole obligation of the appointee will be the successful completion of the proposed study,
publication of the results, preparation and writing up of the MD thesis. The Research Fellow will not
have obligatory clinical duties such as hospital ward rounds and on-call commitments.
Attendance of a hospital diabetes clinic at least once a week will be encouraged though, so that the
appointee can keep up-to-date their skills in the clinical management of diabetes. Moreover, this will
represent a good opportunity to approach potential patients to be recruited into the studies that the
Fellow will be undertaking.
There are also a number of research nurses working within the unit who will be able to support the
Research Fellow’s work such as facilitating patient recruitment and assisting with study days.
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The revised medical curriculum at Liverpool is now well established, and achieved an outstanding
score of 24 out of 24 in the last Teaching Quality Assessment. The course puts strong emphasis on
self-directed learning and vertical integration, with clinical skills introduced early in the course. The
undergraduate teaching load at UHA has increased recently with the changes in the curriculum, and
with the recent expansion of medical student numbers. There will be opportunities for you to be
involved with teaching as appropriate, but this will not be a requirement of the post.
1. Direct Clinical Contact with Patients / Social Contact with Patients
You will work in an area which will require direct clinical and/or social contact with patients. A system
to control the risks is in place. Appointment will be subject to medical assessment by Occupational
You will be required to handle pathogens or potentially infected specimens of unfixed human/animal
tissue (including blood), although appropriate measures will be in place to control the risk. You may be
offered appropriate immunisations and/or records of your work with infectious material/infectious micro-
organisms may be kept. Appointment will be subject to medical assessment by Occupational Health.
3. The Occupational Pension Scheme associated with this appointment is the Universities Superannuation
Scheme (USS). Under the provisions of this scheme a member of staff currently contributes at a rate of
6.35% of his or her pensionable salary and the University such sum as may be required to maintain the full
benefit of the scheme.
Full particulars of the scheme can be obtained, on request, from the Director of Human Resources.
An acceptance of this appointment will be taken as an application to join USS and have the appropriate
contributions deducted from salary unless the Director of Human Resources is expressly notified in writing
either before commencing employment, within three months of that date or on expiry of three months
notice, that the appointee intends to make his or her own pension arrangements.
Should the appointee decide to make his or her own personal pension arrangements, the University will
not contribute to the personal arrangement. No other form of supplementation of pension benefits will be
available from the University.
It may be possible for a newly appointed member of staff who has not been in USS to have his or her
accrued benefits from his or her former pension scheme transferred to the USS. In such a case, USS will
be asked to investigate a transfer payment and will provide, on actuarial advice, a proposal for a number
of years' credit in USS which such payment would secure. The member of staff is at liberty either to
accept this or elect to deal with his or her accrued benefits as determined by the rules of his or her former
4. The appointment is subject to retirement at the age of sixty-five and upon the basis of the Statutes,
Ordinances and Regulations of the University for the time being. The terms of appointment will be in
accordance with the Education Reform Act, 1988.
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EMPLOYEE SPECIFICATION – Shortlisting Criteria
Post Title: Clinical Research Fellow in Diabetes & Endocrinology Salary: £30,685 - £38,911 pa
School: Clinical Sciences Job Ref: R-571117
Attributes No. Essential Criteria Desirable Criteria
(Identified from – Application form/CV/Supporting (Identified from – Application form/CV/Supporting
1. EXPERIENCE 1.1 Experience in diabetes & endocrinology Clinical research experience
2. EDUCATION 2.1 General professional training Intercalated BSc (Hons) / MPhil
TRAINING 2.2 Medical degree MRCP (or equivalent
2.3 Membership exam in clinical speciality as relevant
2.4 Full GMC registration
3. SKILLS, GENERAL 3.1 Good time management skills Working knowledge of using databases, spreadsheets
AND SPECIAL and undertaking basic statistical analyses
KNOWLEDGE 3.2 Good general medical knowledge
4. PERSONAL 4.1 Commitment to a career in Endocrinology & Diabetes
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