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  • 1. CLINICAL RESEARCH FELLOW (DIABETES AND ENDOCRINOLOGY) Job Ref: R-571117 School: Clinical Science Division: Diabetes and Endocrinology Salary: Depending on qualifications and experience Range: £30,685 - £38,911 pa Location: University Hospital Aintree Hours of work: Full time Tenure: Up to 2 years Closing Date: 7 December 2009 Interview Date: 16 December 2009 _____________________________________________________ Informal enquiries to Dr Christina Daousi on 0151 529 5920, email: cdaousi@liv.ac.uk Application Procedure Applications should comprise: *A completed applicant information form * A copy of your full curriculum vitae *A statement indicating the reasons for applying for this post and how your training and experience is relevant. If you have any particular requirements should you be invited to interview, please make this clear in your application. Submitting Applications Applications may be submitted by e-mail to jobs@liv.ac.uk or by post or in person to: The Director of Human Resources (Recruitment), The University of Liverpool, Hart Building, Mount Pleasant, Liverpool L3 5TQ ROYAL MAIL – Postal Pricing System. Please ensure that postal applications carry the correct postage according to the weight and measurement of the item, as items with insufficient postage will be held and delayed by the Royal Mail. Details of their pricing system are available online at www.royalmail.com or from a Post Office branch. Acknowledgement of Applications Please note that we are unable to acknowledge postal applications. If you would like an acknowledgement please enclose a stamped addressed card or envelope, and place it at the front of your application. If you e-mail your application you will receive an automated acknowledgement. Shortlisting and Interviews Shortlisting and interview arrangements are the responsibility of the recruiting Department. Please contact Dr Christina Daousi on 0151 529 5920 if you have a query after the closing date. Outcome of Applications Vacancies at the University often attract a large number of candidates and it is not always possible to respond individually to every application. If you have not heard from the recruiting Department by mid December 2009 please take it that your application has not been successful. Job Ref: R-571117 Page 1 of 9
  • 2. Asylum & Immigration The University will comply with the Immigration, Asylum and Nationality Act 2006, which requires all employees to provide documentary evidence of their legal right to work in this country prior to commencing employment. Candidates will be required to bring their passport (and visa if applicable) to interview so that it can be copied and verified by a member of the Selection Panel. For posts requiring a recognised degree level or equivalent qualification, and where there is no suitable UK or European Economic Area candidate, the University will take the necessary steps to secure UK Border Agency permission for a foreign national to take up employment. Should a candidate require a Certificate of Sponsorship in order to take up a post they will need to meet the UK Boarder Agency Tier 2 Points Based Criteria. A self assessment tool can be found on the UK Border Agency website at: www.ukba.homeoffice.gov.uk/pointscalculator A candidate may also be required to undertake an English Language test prior to commencing work at the University. Details of Home Office approved tests can be found at: www.ukba.homeoffice.gov.uk/sitecontent/newsarticles/pbsapprovedenglishlanguage Further information on the eligibility criteria for Certificates of Sponsorship can be found at: www.ukba.homeoffice.gov.uk/employers/points Diversity and Equality The University of Liverpool is committed to diversity and equality of opportunity. All employees and applicants for jobs will be considered on their abilities and will not be discriminated against on the grounds of age, caring responsibilities, colour, disability, employment status, gender, gender identity, marital status, nationality, race or ethnic origin, religion or belief, sexual orientation, socio-economic status or any other irrelevant distinction. Training is available to support career progression within the University. Two Ticks Disability : Guaranteed Interview Scheme (GIS) The University of Liverpool is commitment to the employment of disabled people, and as part of our commitment, we guarantee to interview all disabled applicants who meet the essential criteria for a post and consider them on their abilities. To apply for a post under the disability GIS, you must disclose your disability (as defined by the Disability Discrimination Act, 2005), and mark X in the yes box on the Equal Opportunities Employment Form. This form must be returned with your application form. Full details of the scheme are available at www.liv.ac.uk/hr/organisational-development/Two_Ticks.htm Accessibility If you require copies of documentation in alternative formats, for example, large print or Braille, please contact jobs@liv.ac.uk or telephone 0151 794 6771. If you have any other requirements which will help you access the application or interview process or employment opportunities at the University of Liverpool, please let us know by contacting jobs@liv.ac.uk or telephone 0151 794 6771. Smoking The University has adopted a Code of Practice on Smoking, copies of which are available from the Human Resources Department website www.liv.ac.uk/hr Job Ref: R-571117 Page 2 of 9
  • 3. Post This post is being funded by the NovoNordisk UK Research Foundation (an NIHR partner) and would be suitable for a candidate pursuing a career in Diabetes & Endocrinology, who intends to spend more time in research, with the aim of achieving a higher degree (MD). You will be expected to have experience in the speciality, either at Senior House Officer or Registrar/ST level; research experience (for example as an academic F2) would be an advantage. Membership of the Royal College of Physicians (UK) or equivalent qualifications would be desirable. You should be fully registered with the General Medical Council. You will be based at University Hospital Aintree in Liverpool and will be a member of the Diabetes & Endocrinology Directorate, within the Clinical Research Group. Area The North West Strategic Health Authority was formed from the amalgamation of the Mersey, North Western and part of the Northern RHAs and has a population of 6.6million. Merseyside itself consists of 5 metropolitan boroughs, the largest being the City of Liverpool. Sefton Metropolitan Borough is contiguous and stretches along the coastal strip north of the River Mersey as far as Southport. The Sefton population is served by two main Hospital complexes, namely Aintree Hospitals, serving South Sefton, and Southport and Formby District General Hospitals serving the North. There are 294,000 residents living within the geographical boundaries of Sefton Health Authority and around 175,000 in the southern part of the area. The figure is expected to decline slightly but within this overall decline the elderly population will increase. Liverpool is a dynamic city. It has experienced a major revival over the past few years and Merseysiders enjoy a superb quality of life. It is unusually compact and a journey to the centre rarely takes more than 30 minutes. The county abounds with fine architecture, lively cultural pursuits and outstanding sport. Tourism has become a major industry and 20 million people visited the city last year, attracted both by the area’s natural and man made assets. Liverpool was the European Capital of Culture for 2008. Merseyside’s theatres, museums and art collections are now amongst its strongest assets. The city is alive with independent theatre groups, authors, poets and dance groups. Photography, sculpture, street art and video makers abound. The Walker Art Gallery contains a collection equal to any in the provinces and the Tate Gallery opened in 1988 on Liverpool’s waterfront in the refurbished Albert Dock. The Philharmonic Orchestra is nationally acclaimed and there is a full range of musical activities of all types. There are both Anglican and Roman Catholic Cathedrals and facilities for worship of every other faith in the city. There are excellent schools for both sexes, including a variety of denominational schools in the private and state sector. The University Medical School is within 20 minutes drive of Aintree Hospitals. There is very good housing in pleasant suburbs near the sea and in rural areas which is easily available. Two airports are within easy reach. Liverpool and Manchester International Airport are within half to three quarters of an hour’s driving time. There are excellent train services and motorway links to all parts of the country with easy access to the national parks, North Wales, the Peak District, the Lake District, as well as to both Lancashire and the North Wales coasts. Job Ref: R-571117 Page 3 of 9
  • 4. Residence You will normally be required to live within 10 miles of the University Hospital Aintree so as to allow easy access to the Hospital as required. University Hospital Aintree The University Hospital Aintree is a large teaching hospital for the University. It houses a large Accident and Emergency Department and most major acute specialties are represented including General Surgery, ENT, Orthopaedics, Urology, and acute medical services. In addition, there are specialised units for Diabetes & Endocrinology, Cardiology, Thoracic Medicine, Nephrology, Rheumatology and Rehabilitation, Gastroenterology, Medicine for the Elderly, Regional Maxillofacial and Cancer of the Head and Neck and the Younger Disabled Unit. There is a fully equipped 17 bed Critical Care Unit (General Intensive Care Unit and High Dependency Unit) and a large Cardiac Intensive Care Unit as well as a dedicated acute Stroke Unit. It is also the site of the Sub-Regional Public Health Laboratory and there is a large Radiology Department servicing the Hospital. A Cardiac Catheter Laboratory opened in September 2003. The Walton Centre for Neurology and Neurosurgery NHS Trust The Walton Centre is an NHS Trust providing neurology and neurosurgical services to a catchment population consisting of Merseyside, North Wales, the Isle of Man and part of West Lancashire. The Centre is a new purpose built Hospital in the grounds of University Hospital Aintree and has 63 Neurosurgical beds, 36 neurology beds, 11 paediatric beds, 4 pain relief beds, ITU and Day-Case Unit. The Department of Neuroscience of the Faculty of Medicine of the University of Liverpool is based at the Walton Centre. Walton Hospital Walton Hospital is situated approximately 4 miles from the city centre and 2½ miles from the University Hospital Aintree, providing Out-patient and Day Case services. The Ophthalmology Directorate is based on this site. Education, Teaching and Research The University Hospital Aintree has a strong commitment to and an excellent reputation for teaching and research, providing facilities for undergraduate clinical teaching and postgraduate work for the University with which there is a close relationship. The Trust makes a major contribution to the teaching and training of medical students and postgraduate doctors. Strong links with the University have been forged over the past few years to develop the Trust’s academic base. Five University Professors with duties entirely at University Hospital Aintree have been appointed. Professor John Wilding, Chair of Medicine and Director of the Diabetes & Endocrinology Clinical Research Group, Professor Ian MacFarlane, Honorary Chair in Diabetes & Endocrinology, Professor Geoff Gill, Chair of International Medicine, Professor Peter Calverley Chair in Rehabilitation Medicine (Respiratory), and Professor Rob Moots, Chair of Rheumatology. These appointments play a vital part in the Trust’s intention to enhance its academic reputation. Many other specialties also have academic appointees. The Trust has an Associate Medical Director - Medical Education (Professor John Earis), an Associate Medical Director - Research and Development (Professor R J Moots), and an Associate Medical Director – Clinical Governance (Dr N P Mercer). A varied programme of lectures and seminars in a wide variety of specialties is organised by the Postgraduate Centre and these are well supported by Hospital medical staff. There is a monthly clinical Grand Round and Clinical Audit meetings are held regularly. There is an excellent medical illustration (photography) department. Job Ref: R-571117 Page 4 of 9
  • 5. The Clinical Sciences Centre for Research and Education houses the research units and offices of the University Clinical Departments and those of the Walton Centre for Neurology and Neurosurgery NHS Trust. In addition, the new building embraces the Directorate of Medical Education, comprising offices, seminar rooms and undergraduate facilities. The Centre has a Lecture Theatre, with a capacity of 225, fully equipped with audio visual aids and with the built in facility for video-conferencing. The Centre has already become a popular venue for a number of national meetings, seminars and symposia. There is an exhibition hall next to the Lecture Theatre. The Library and Information Resource Centre, on the first floor, provides a multi-disciplinary service including reference and lending collections from the School of Health Studies, the Postgraduate and Walton Centre libraries and includes network and stand-alone electronic information services, including CD Rom and on-line databases. Client training and support services, including interactive workbooks, electronic information/self study packages, group training sessions and on screen printing can be provided. Remote access to the information system is available outside opening hours at designated locations within the Hospital. Research in Endocrinology, Diabetes and Obesity at UHA The Diabetes and Endocrinology Clinical Research Group has its clinical base at the UHA, where Professor John Wilding directs the Clinical Research Unit (CRU) which is housed in the Clinical Sciences Centre. The Group is busy and productive and has a large external grant income (>£5 million since 1998). The Group has an excellent publication output, for which it is recognised at international level. External funding has been obtained to equip the clinical physiology laboratories in the Clinical Sciences Centre for a wide range of metabolic and vascular studies in obesity and diabetes, and molecular and tissue-culture laboratories are also available in the Centre. Facilities available include those needed for metabolic studies such as euglycaemic clamps, assessment of metabolic rate, measurements of vascular function, heart rate variability, baroreflex sensitivity, pulse wave analysis and microneurography. Currently, the senior members of the Group comprise Professor John Wilding, Professor Ian MacFarlane, Professor Geoff Gill, Dr Christina Daousi and Dr Daniel Cuthbertson who supervise clinical research at the Clinical Sciences Centre of UHA. The Group also supervise non- clinical researchers in the Neuroendocrine and Obesity Research Unit (Neurob), headed by Professor Paul Trayhurn which is housed in the Department of Medicine at the Royal Liverpool University Hospital near the main University Campus. Professor Gill has interests in cardiovascular risk in type 2 diabetes, long-term survivors of type 1 diabetes, unstable type 1 diabetes and hypoglycaemia. He also has an interest in diabetes in the tropics, and has close links with the Liverpool School of Tropical Medicine. Staff within the Diabetes & Endocrinology Clinical Research Group supporting research in diabetes and endocrinology currently comprises a Clinical Lecturer (new appointment pending), four Clinical Research Fellows, five Research Nurses and a Research Dietician. The main areas of research are metabolic and vascular studies in obesity and diabetes, translational research into incretin hormones, hypoglycaemia, non-alcoholic fatty liver disease, PCOS, risk factors in type 2 diabetes and studies in unstable type 1 diabetes, together with clinical trials of new treatments in diabetes and obesity, adult growth hormone deficiency and hypothalamic obesity. The Unit actively collaborates with several other groups on site, including NHS and academic consultants in Diabetes and Endocrinology, Respiratory Medicine, Neurology and Clinical Biochemistry. The Diabetes and Endocrinology Directorate The Diabetes and Endocrinology Directorate at Aintree Hospitals serves the local population (approximately 350,000) and, because of the specialist interests of the consultants, also takes patients from a much wider catchment area including the North West of England and North Wales. As well as managing diabetic patients, the existing Consultants provide essential services in related disciplines, notably endocrinology, obesity and lipid disorders, and also fulfil a substantial General Medical commitment. Job Ref: R-571117 Page 5 of 9
  • 6. The Diabetes Centre at Aintree Hospital was established in 1990 in purpose-built premises at Walton Hospital. A comprehensive range of out-patient services is provided, with easy access to the multi- disciplinary diabetes care team. There is a Nurse Consultant in Diabetes/Endocrinology (Maureen Wallymahmed) and a team of Specialist Nurses (4), Diabetes Educators and Ward Liaison Nurses (4), Dieticians and Chiropodists. There are also close links with the Ophthalmologists, Vascular Surgeons, Nephrologists and Endocrine Surgeons. Daily diabetes clinics and health education sessions are held, with separate clinics for adolescents, foot problems, CV risk factor management, insulin pump service and pregnant patients with diabetes. In addition, lipid, endocrinology and obesity clinics are held weekly. Combined neurosurgical- endocrine clinics are held in The Walton Centre for Neurology & Neurosurgery and close links exist with the endocrine surgery clinics. In 2005-6 there were more than 6,000 out-patient attendances at the Diabetes Centre and over 3,000 patients are registered at the Centre. Referrals from outside the usual catchment population are also increasing. In view of the increasingly elderly population in Sefton and the high prevalence (10%) of diabetes in the over 70s, the demand for diabetes care will undoubtedly continue to increase. It is predicted that the prevalence of diabetes will double in the next decade. Since its inception, the Aintree Diabetes Centre has been active in developing links with Primary Care and Community colleagues and there is an agreed shared-care protocol “Diabetes Care Guidelines” in conjunction with South Sefton and Liverpool Primary Care Trusts. The Directorate is responsible for 52 medical beds at University Hospital Aintree on two wards. The Consultant staff participate in the Medical Directorate “post-take” ward round system which currently involves 5 teams of physicians (Gastroenterology, Cardiology, DME, Respiratory and Diabetes/Endocrine/Nephrology). Medical Staffing The Consultants working in the Directorate all undertake General Medical duties and have special interests as follows: Professor John Wilding (Head of the Diabetes & Endocrinology academic unit) Obesity and type 2 diabetes Professor I A MacFarlane Neuroendocrinology, adolescent diabetes, endocrinology (including MEN syndrome) Professor Geoffrey Gill Brittle diabetes, diabetic foot problems, risk factors in type 2 diabetes Dr S Benbow (Clinical Director) Community Diabetes Care, diabetic neuropathy, diabetic foot problems Dr Christina Daousi Incretin hormones in obesity and diabetes, type 1 diabetes, neuroendocrinology Dr Daniel Cuthbertson Diabetes, General Endocrinology, MEN syndrome Dr I F Casson Medical Disorders of Pregnancy Job Ref: R-571117 Page 6 of 9
  • 7. The Medical Staff complement for the Directorate is: Lecturer (SpR) 1 Specialist Registrars 4 Senior House Officers 3 Foundation Yr 2 1 Pre-registration House Officers 3 Dr van Heyningen, Consultant in Clinical Chemistry and the Biochemistry Department Associate Specialist Dr David Wile also work closely with the directorate in the Lipid Disorders and Diabetes Clinics. 1. Job Description Research The role will undertake research work into the pancreatic and extra-pancreatic effects of the incretin hormone GIP (glucose-dependent insulinotropic hormone) in humans in health and type 2 diabetes mellitus. The proposed work is built on existing research interests and is a natural extension of research carried out recently by one of the supervisors Dr C Daousi. The research unit has experience in undertaking infusion studies in humans and all the necessary protocols are in place for the proposed experimental procedures. You will receive the appropriate training for the procedures that will be employed in your studies. The appointee will be expected to register for a higher degree (MD) and Dr Daousi and Dr Cuthbertson will be overseeing your work. The Research Fellow will work as a member of the Diabetes & Endocrinology Clinical Research Group, which has a large external grant income and also has a longstanding and highly successful track record in clinical research and an excellent publication output, for which it is recognised at international level. The Diabetes and Endocrinology Clinical Research Group is part of the University’s School of Clinical Sciences and is based in the Clinical Sciences Centre at UHA, where Professor John Wilding directs the Clinical Research Unit. The Research Fellow will have access to the clinical physiology laboratories in the Clinical Sciences Centre which are appropriately equipped for a wide range of metabolic and vascular studies in obesity and diabetes; molecular and tissue-culture laboratories are also available in the Centre. Facilities available include those needed for metabolic studies such as hyperglycaemic/euglycaemic clamps, assessment of metabolic rate, adipose tissue biopsies, measurements of vascular function, heart rate variability, baroreflex sensitivity, stable isotope methodology, pulse wave analysis and microneurography. There are a number of academic workshops run by the University of Liverpool which the research fellow will be encouraged to attend. These workshops are designed to help develop a number of other skills and include advanced statistics workshops and career skills workshops. In addition, the NovoNordisk UK Research Foundation will provide the Research Fellow with a number of training opportunities and training courses related to research practice, analysis and presentation of their results, attendance at which is obligatory. The Research Fellow will also be expected to participate in the medical and scientific meetings of Diabetes UK at least once a year to present the results emanating from the research project and the Research Foundation meetings/symposiums. Expenses will be provided. Clinical The sole obligation of the appointee will be the successful completion of the proposed study, publication of the results, preparation and writing up of the MD thesis. The Research Fellow will not have obligatory clinical duties such as hospital ward rounds and on-call commitments. Attendance of a hospital diabetes clinic at least once a week will be encouraged though, so that the appointee can keep up-to-date their skills in the clinical management of diabetes. Moreover, this will represent a good opportunity to approach potential patients to be recruited into the studies that the Fellow will be undertaking. There are also a number of research nurses working within the unit who will be able to support the Research Fellow’s work such as facilitating patient recruitment and assisting with study days. Job Ref: R-571117 Page 7 of 9
  • 8. Teaching The revised medical curriculum at Liverpool is now well established, and achieved an outstanding score of 24 out of 24 in the last Teaching Quality Assessment. The course puts strong emphasis on self-directed learning and vertical integration, with clinical skills introduced early in the course. The undergraduate teaching load at UHA has increased recently with the changes in the curriculum, and with the recent expansion of medical student numbers. There will be opportunities for you to be involved with teaching as appropriate, but this will not be a requirement of the post. ____________________________________ 1. Direct Clinical Contact with Patients / Social Contact with Patients You will work in an area which will require direct clinical and/or social contact with patients. A system to control the risks is in place. Appointment will be subject to medical assessment by Occupational Health. 2. Pathogens You will be required to handle pathogens or potentially infected specimens of unfixed human/animal tissue (including blood), although appropriate measures will be in place to control the risk. You may be offered appropriate immunisations and/or records of your work with infectious material/infectious micro- organisms may be kept. Appointment will be subject to medical assessment by Occupational Health. 3. The Occupational Pension Scheme associated with this appointment is the Universities Superannuation Scheme (USS). Under the provisions of this scheme a member of staff currently contributes at a rate of 6.35% of his or her pensionable salary and the University such sum as may be required to maintain the full benefit of the scheme. Full particulars of the scheme can be obtained, on request, from the Director of Human Resources. An acceptance of this appointment will be taken as an application to join USS and have the appropriate contributions deducted from salary unless the Director of Human Resources is expressly notified in writing either before commencing employment, within three months of that date or on expiry of three months notice, that the appointee intends to make his or her own pension arrangements. Should the appointee decide to make his or her own personal pension arrangements, the University will not contribute to the personal arrangement. No other form of supplementation of pension benefits will be available from the University. It may be possible for a newly appointed member of staff who has not been in USS to have his or her accrued benefits from his or her former pension scheme transferred to the USS. In such a case, USS will be asked to investigate a transfer payment and will provide, on actuarial advice, a proposal for a number of years' credit in USS which such payment would secure. The member of staff is at liberty either to accept this or elect to deal with his or her accrued benefits as determined by the rules of his or her former scheme. 4. The appointment is subject to retirement at the age of sixty-five and upon the basis of the Statutes, Ordinances and Regulations of the University for the time being. The terms of appointment will be in accordance with the Education Reform Act, 1988. Job Ref: R-571117 Page 8 of 9
  • 9. EMPLOYEE SPECIFICATION – Shortlisting Criteria Post Title: Clinical Research Fellow in Diabetes & Endocrinology Salary: £30,685 - £38,911 pa School: Clinical Sciences Job Ref: R-571117 Attributes No. Essential Criteria Desirable Criteria (Identified from – Application form/CV/Supporting (Identified from – Application form/CV/Supporting Statement/Interview/References) Statement/Interview/References) 1. EXPERIENCE 1.1 Experience in diabetes & endocrinology Clinical research experience 2. EDUCATION 2.1 General professional training Intercalated BSc (Hons) / MPhil QUALIFICATIONS TRAINING 2.2 Medical degree MRCP (or equivalent 2.3 Membership exam in clinical speciality as relevant 2.4 Full GMC registration 3. SKILLS, GENERAL 3.1 Good time management skills Working knowledge of using databases, spreadsheets AND SPECIAL and undertaking basic statistical analyses KNOWLEDGE 3.2 Good general medical knowledge 4. PERSONAL 4.1 Commitment to a career in Endocrinology & Diabetes ATTRIBUTES AND CIRCUMSTANCES Job Ref: R-571117 Page 9 of 9