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Curriculum Vitae

                                      James (Jay) C. Cross

Address              Department of Biochemis...
James C. Cross... 2

                  Hormone Research Institute, University of California, San Francisco
Jun 1992-Aug 19...
James C. Cross... 3

Alberta Heritage Foundation of Medical Research (AHFMR) Senior Scholarship Award, 2001-2006
Canadian ...
James C. Cross... 4

   Patricia Hunter - Dept of Molecular and Medical Genetics, University of Toronto (Feb 1996 - Oct
  ...
James C. Cross... 5

University of Calgary
   Colleen O’Sullivan (Ph.D. student with Dr Rancourt, Dept of Biochemistry and...
James C. Cross... 6

Head, SLRI Retreat, 1998 – 2000

University of Calgary
Director, Institute of Maternal and Child Heal...
James C. Cross... 7


12. Cross JC, Roberts RM (1991). Constitutive and trophoblast-specific expression of a class of
    ...
James C. Cross... 8


27. MacAuley A, Cross JC, Werb Z (1998). Reprogramming the cell cycle for endoreduplication in
     ...
James C. Cross... 9

41. Copeman J, Han RNN, Caniggia I, McMaster M, Fisher SJ, Cross JC (2000).
     Posttranscriptional ...
James C. Cross... 10


57. Cross JC, Hemberger M, Lu Y, Nozaki T, Whiteley K, Masutani M, Adamson SL (2002).
    Trophobla...
James C. Cross... 11

71. Zhao S-H, Simmons DG, Cross JC, Scheetz TE, Casavant TL, Soares MB, Tuggle CK (2004).
     PLET1...
James C. Cross... 12


6. Cross JC, Anson-Cartwright L, Hattori N, Nakayama H, Riley P, Scott IC, Fisher SJ, Watson AJ,
  ...
James C. Cross... 13

Wayne State University, April 1998
University of Guelph, Chappel Memorial Lecturer in Biomedical Sci...
James C. Cross... 14

University of Colorado Health Sciences Centre, April 2003
Conference on Female Reproductive Tract Bi...
James C. Cross... 15

9.   Leaman DW, Cross JC, Roberts RM (1990). Species distribution of genes for the trophoblast
     ...
James C. Cross... 16


24. Riley P, Cross JC (1997). Analyzing the function of Hxt in placental and cardiac development.
 ...
James C. Cross... 17

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41. Ha...
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  1. 1. Curriculum Vitae James (Jay) C. Cross Address Department of Biochemistry & Molecular Biology Genes & Development Research Group University of Calgary Faculty of Medicine Health Sciences Centre Room 2279 3330 Hospital Drive, N.W. Calgary, Alberta T2N 4N1 Canada Tel: (403) 220-6876 Fax: (403) 270-0737 e-mail: jcross@ucalgary.ca Date of Birth March 14, 1962 Citizenship Canadian Education McGill University, Montreal, Canada (1980-1983) University of Saskatchewan, Saskatoon, Canada, D.V.M 1987 University of Missouri-Columbia, U.S.A., Ph.D. 1991 Appointments Sep 1994 - Jun 2000 Staff Scientist, Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto Nov 1994 - Mar 1999 Assistant Professor, Department of Obstetrics & Gynaecology, University of Toronto Sep 1995 - Jun 1999 Assistant Professor, Department of Molecular & Medical Genetics, University of Toronto Jul 1999 – Jun 2000 Associate Professor, Departments of Obstetrics & Gynaecology, and Molecular & Medical Genetics, University of Toronto Jul 2000 – Jun 2002 Associate Professor, Departments of Biochemistry & Molecular Biology, and Obstetrics & Gynaecology, University of Calgary Jul 2002 – present Professor, Departments of Biochemistry & Molecular Biology, and Obstetrics & Gynaecology, University of Calgary Jun 2002 – present Director, CIHR Training Program in Genetics, Child Development and Health Jul 2003 – Feb 2004 Chair, Genes & Development Research Group, University of Calgary Aug 2003- present Director, Institute of Maternal and Child Health, University of Calgary Training Apr-Dec 1982 Research Assistant (Dr. Bruce R. Downey) Dept. of Animal Science, McGill University Apr 1984-Apr 1986 Research Assistant (Dr. Jack G. Manns) Dept. of Veterinary Physiological Sciences, University of Saskatchewan May-Aug 1986 Research Assistant (Dr. Harold R. Behrman) Dept. of Obstetrics and Gynecology, Yale University School of Medicine Aug 1987-Jan 1991 Ph.D. Program (Dr. R. Michael Roberts) Departments of Animal Sciences & Biochemistry, University of Missouri-Columbia Apr 1991-May 1992 Post-doctoral Fellow (Dr. William J. Rutter)
  2. 2. James C. Cross... 2 Hormone Research Institute, University of California, San Francisco Jun 1992-Aug 1994 Post-doctoral Fellow (Dr. Zena Werb) Laboratory of Radiobiology and Environmental Health, University of California, San Francisco Current Research Funding CIHR Operating Grant "Feto-Maternal Interactions in the Human Placenta", 1995-1998, 1998-2001 “Activin and BMP Signaling in Placental Development”, 2001-2006 CIHR Operating Grant "Transcriptional Regulation of Trophoblast Development" 1995-2000, 2000-2005 CIHR Operating Grant "The Role of the Hxt Transcription Factor in Cardiac Development", 1998-2001 “Regulation of Cardiac Morphogenesis”, 2001-2006 CIHR Operating Grant “Chorioallantoic Placental Development”, 2000-2003, 2003-2008 Heart and Stroke Foundation Grant “Modulation of the Cardiomyocyte Cell Cycle”, 2001-2003 Stem Cell Network “Functional and Molecular Characterization of Cardiac Stem Cells”, 2003-2005 AHFMR Training Program “Training Program in Genetics, Child Development and Health”, 2002-2005 CIHR Training Program “Training Program in Genetics, Child Development and Health”, 2002-2008 CIHR Multi-User Equipment “Regional Embryonic Stem Cell/Targeted Mutagenesis Facility”, 2001-2004 “Centre for Mouse Genomics”, 2004-2009 CFI/ASRIP Infrastructure Grant “Centre for Mouse Genetics, Physiological Systems and Disease”, 2003-2007 Honours and Awards Faculty Scholar, J.W. McConnell Scholarship (McGill University) 1981, 1982, 1983 Macdonald Medal for First Proficiency (McGill University) 1982, 1983 Ellin-Beit Speyer Scholarship (McGill University) 1983 Canadian Society of Animal Science Book Prize 1983 William Sidey Scholarship for Achievement (University of Saskatchewan) 1984 Natural Sciences and Engineering Research Council of Canada Undergraduate Research Award, 1982, 1984, 1985 W.B. Saunders Award in Medicine, University Scholarship, Pfizer Award for Leadership and Scholarship (University of Saskatchewan) 1986 First Proficiency Award for Graduating Class, Carl Tucker Award for Achievement (University of Saskatchewan) 1987 Young Investigator Award, Society for the Study of Reproduction 1988 International Society for Interferon Research Travel Award 1990, 1992 MRC of Canada Fellowship for Post-Graduate Studies 1987-1991 MRC of Canada Fellowship for Post-Doctoral Studies 1991-1994 American Heart Association Post-doctoral Fellowship, awarded June 1, 1994 MRC of Canada Scholarship, 1996-2001 University of Guelph, Chappel Memorial Lecturer in Biomedical Sciences, June 1998 Chair’s Award for Outstanding Research Potential, Department of Obstetrics and Gynaecology, University of Toronto, 1999 Premier’s Research Excellence Award (PREA) of Ontario, 1999-2004
  3. 3. James C. Cross... 3 Alberta Heritage Foundation of Medical Research (AHFMR) Senior Scholarship Award, 2001-2006 Canadian Institutes of Health Research (CIHR) Investigator Award, 2001-2006 Schultz Award for Excellence, Department of Biochemistry & Molecular Biology, University of Calgary, 2004 IFPA Award in Placentology, 2004 Professional Affiliations American Association for the Advancement of Science, American Society for Cell Biology, Society for the Study of Reproduction, Society for Developmental Biology, Placental Association of the Americas, International Federation of Placental Associations Professional Activities Reviewer for academic journals: Biology of Reproduction, Cell Growth and Differentiation, Development, Developmental Biology, Developmental Dynamics, Genesis, Genes & Development, Journal of Endocrinology, Mechanisms of Development, Molecular Reproduction and Development, Placenta, Reviews in Reproduction, Science Reviewer for granting agencies: MRC, NIH, NSERC, Wellcome Trust, Genesis Foundation, Jeffress Foundation, Hong Kong Research Grants Council, Hospital for Sick Children Foundation, Manitoba Health Research Council, Alberta Cancer Board, Alberta Heritage Foundation Symposia and Meeting Organization: Co-chair of the “International Symposium on The Cell Cycle”, Mount Sinai Hospital, June 11-12, 1998; Chair of the Symposium on Mammalian Embryogenesis and Implantation, Calgary, June 21, 2002; Vice-chair, Gordon Conference on Reproductive Tract Biology, 2004; Co-chair, Gordon Conference on Reproductive Tract Biology, 2006 Editorial Boards: Placenta (1999-2004) Biology of Reproduction (2004-present) Grant Review Panels: CIHR/MRC (Endocrinology Panel) May 1999-Jun 2002 CIHR (Developmental Biology Panel) Jul 2003-present NIH (Reproductive Biology Panel) June 1999 Invited participant in policy discussions: National Academy of Sciences (USA) Study on Human Cloning, Invited Speaker, Washington, August 2001 CIHR Brainstorming Panel, Ottawa, August 2001 Teaching Post-doctoral fellows supervised: Hiroki Nakayama, Sept 1995-Feb 1998 (Notch signaling in the placenta) Paul Riley, Feb 1996-Feb 1999 (Role of Hxt in embryonic and extraembryonic development James Copeman, Nov 1996-Dec 1999 (Regulation of MHC class I antigen presentation) Naka Hattori, Feb 1998-Apr 2000 (Control of the endoreduplication cell cycle) Hideyuki Yamamoto, Dec 1999-present (Control of the endoreduplication cell cycle) Myriam Hemberger, Mar 2000-Dec 2003 (Trophoblast cell invasion) Brent Bany, Jul 2001-May 2003 (Embryo-induced differentiation of the uterus) David Simmons, March 2002-present (Regulation of Gcm1) David Natale, May 2003-present (Gcm1 target genes) Michael Hesse, April 2004-present (Developmental control of the cell cycle) Haruo Nakano, July 2004-present (Wnt signaling in the placenta) Graduate students supervised: Ian Scott - Dept of Molecular and Medical Genetics, University of Toronto (Jan 1995 – Mar 2002) Research topic: Helix-loop-helix transcription factors and trophoblast development
  4. 4. James C. Cross... 4 Patricia Hunter - Dept of Molecular and Medical Genetics, University of Toronto (Feb 1996 - Oct 1998) M.Sc. thesis title: Mrj encodes a DnaJ-related co-chaperone is required for placental development in mice Tyler Davies - Dept of Molecular and Medical Genetics, University of Toronto (May 1996 - Dec 1997; withdrew from program) Research topic: Control of cell division in the mouse placenta Jonathon Gabor - Dept of Molecular and Medical Genetics, University of Toronto (Nov 1997 – Jan 2001) M.Sc. thesis title: Role of Fzr in cell cycle control Melissa Miller, Department of Biochemistry & Molecular Biology, University of Calgary (Sep 2001 – Sep 2002; withdrew from program) Erica Watson, Department of Biochemistry & Molecular Biology, University of Calgary (May 2002 – present) Amanda Fortier, Department of Biochemistry & Molecular Biology, University of Calgary (Sep 2002 – present) Dana Rourke, Department of Biochemistry & Molecular Biology, University of Calgary (May 2003 – present) Dong Hu, Department of Biochemistry & Molecular Biology, University of Calgary (December 2003 – present) Summer students supervised: Danny Reda (June-August 1995), Shirley Lam (June-August 1995); Wendy Tsang (June-August 1996); Alyssa Cruz (July-August 2001), Alastair Davies (July-August 2002, July-August 2003, July-August 2004) High school students supervised: Harald Au, Brebeuf Academy (Oct 97 - Apr 98), Eric Chiu, Brebeuf Academy (Oct 1998- Apr 1999) Graduate Committees: University of Toronto Ryan Ou (Ph.D. student with Dr. Lye, Dept of Physiology (1995 - 1998) Ching-Ching Leow (M.Sc. student with Dr. Egan, Dept of Molecular and Medical Genetics, 1996- present) Tilo Kunath (Ph.D. student with Dr. Rossant, Dept of Molecular and Medical Genetics, 1997- present) Kyle Cowan (M.Sc. student with Dr. Rabinovitch, Dept of Pathology, 1997- 2000) David Ng (M.Sc. student with Dr. McInnes, Dept of Molecular and Medical Genetics, 1997- present) Deboleena Roy (M.Sc. student with Dr. Belsham, Dept of Physiology, 1997-present) Benoit St. Pierre (Ph.D. student with Dr. Egan, Dept of Molecular and Medical Genetics, 1998- present)
  5. 5. James C. Cross... 5 University of Calgary Colleen O’Sullivan (Ph.D. student with Dr Rancourt, Dept of Biochemistry and Molecular Biology, 2000-present) Matt Larouche (Ph.D. student with Dr Hawkes, Dept of Neuroscience, 2002-present) External Examiner for M.Sc. Examination Committees: Jeffrey Gingrich, Dept of Molecular and Medical Genetics, Sep 1997 Dana Cohen, Dept of Molecular and Medical Genetics, July 1998 Elke Aippersbach, Dept of Molecular and Medical Genetics, Sep 1998 Denise Yu, Dept of Physiology, Nov 1998 Kathleen Lumb, Department of Cardiovascular and Respiratory Sciences, May 2003 External examiner for Ph.D. Re-classification and Qualification Committees: Benoit St. Pierre, Dept of Molecular and Medical Genetics, University of Toronto, Aug 1996 Elke Aipperbach, Dept of Molecular and Medical Genetics, University of Toronto, June 1997 Lynn Mar, Dept of Zoology, University of Toronto, June 1998 Jasmine Wong, Dept of Molecular and Medical Genetics, Aug 1998 Colleen O’Sullivan, Dept of Biochemistry and Molecular Biology, Nov 2000 External Examiner for Ph.D. Examination Committees: Mary Shago, Dept of Molecular and Medical Genetics, University of Toronto 1996 Shaojun Tang, Dept of Molecular and Medical Genetics, University of Toronto 1997 Andrea Jurisicova, Dept of Zoology, University of Toronto 1997 Courses Taught: University of Toronto Physiology PSL 422 (lecturer, 2 hours, “The Placenta: Development, Functions and Clinical Problems”), 1996 - 1997 Physiology PSL 460 (lecturer, 2 hours, “The Placenta: Development, Functions and Clinical Problems”), 1998 - present Developmental Biology JDB 1025 (course coordinator, 36 hours), 1998 - present Molecular and Medical Genetics MGB 452 (course coordinator, 10 hours), winter 2000 University of Calgary Introduction to Model Systems (lecturer, 2 hours), 2000-present Genes and Development MDSC 609.02 (Coordinator, 30 hours), winter 2002 Advanced Developmental Biology CMMB 505 (offered jointly with MDSC 609.02), winter 2002 Embryonic Stem Cells, winter 2002 Cardiac Development, winter 2003 University Activities and Administrative Duties University of Toronto Member, Program in Developmental Biology Organizer of “Trophoblast Club”- monthly meetings of individuals from the University of Toronto (MSH, HSC, TGH, Women’s College Hospital, Zoology and Physiology) spanning basic research through clinical interests in the placenta, 1994-1997 Member, Admissions Committee, Graduate Department of Molecular and Medical Genetics, 1999-2000 Member, SLRI equipment committee, 1995 - 1998 Member, Program committee for SLRI Retreat, 1995 - 1997 Member, SLRI computer users group, 1995 - 1998 Head, SLRI seminar program, 1996 - 1998 Co-Head, SLRI Symposium, 1998
  6. 6. James C. Cross... 6 Head, SLRI Retreat, 1998 – 2000 University of Calgary Director, Institute of Maternal and Child Health, 2003-present Director, Centre for Mouse Genomics, University of Calgary, 2001-present Leader, CFI Application for “Centre for Mouse Genetics, Physiological Systems and Disease, 2001 Director, CIHR Training Program in Genetics, Child Development and Disease (2002 – present) Chair, Genes & Development Research Group (2003) Member, Mouse Users Committee, Faculty of Medicine Ad-hoc committee for animal welfare Published Refereed Papers 1. Cross JC, Rutter, LM, Manns JG (1987). Effects of progesterone and weaning on LH and FSH responses to naloxone in postpartum beef cows. Domestic Animal Endocrinology 4:111-122 2. Cross JC, Soodak LK, Musicki B, Behrman HR (1987). Absence of detectable phosphocreatine in rat luteal cells. American Journal of Physiology 253:E391-394 3. Cross JC, Roberts RM (1989). Porcine conceptuses secrete an interferon during the pre- attachment period of early pregnancy. Biology of Reproduction 40:1109-1118 4. Cross JC, Farin CE, Sharif SF, Roberts RM (1990). Characterization of the antiviral activity produced by murine conceptuses: Absence of placental mRNAs for interferon alpha or beta. Molecular Reproduction and Development 26:122-128 5. Roberts RM, Cross JC, Farin CE, Hansen TR, Klemann SW, Imakawa K (1990). Interferons at the placental interface. Journal of Reproduction and Fertility Supplement 41:63-74 6. Roberts RM, Farin CE, Cross JC (1990). Trophoblast proteins and maternal recognition of pregnancy. In: Oxford Reviews of Reproductive Biology (S Milligan, ed), Oxford University Press 12:147-180 7. Klemann SW, Li Jz, Imakawa K, Cross JC, Francis H, Roberts RM (1990). The production, purification and bio-activity of recombinant bovine trophoblast protein-1 (bovine trophoblast interferon). Molecular Endocrinology 4:1506-1514 8. Schalue-Francis TK, Farin PW, Cross JC, Francis H, Roberts RM (1990). Effect of injected interferon-n 1 on oestrous cycle length and pregnancy success in sheep. Journal of Reproduction and Fertility 91:347-356 9. Hansen TR, Leaman DW, Cross JC, Mathialagan N, Bixby JA, Roberts RM (1991). The genes for the trophoblast interferons and the related interferon-, II possess distinct 5'-promoter and 3'- flanking sequences. Journal of Biological Chemistry 266:3060-3067 10. Hansen TR, Cross JC, Farin CE, Imakawa K, Roberts RM (1991). Slowed transcription and rapid mRNA turnover contribute to a decline in in vitro oTP-1 synthesis. Biology of Reproduction 45:94-100 11. Farin CE, Cross JC, Tindle NA, Murphy CN, Farin PW, Roberts RM (1991). Induction of trophoblastic interferon expression in ovine blastocysts after treatment with double-stranded RNA. Journal of Interferon Research 11:151-157
  7. 7. James C. Cross... 7 12. Cross JC, Roberts RM (1991). Constitutive and trophoblast-specific expression of a class of bovine interferon genes. Proceedings of the National Academy of Sciences U.S.A. 88:3817-3821 13. Roberts RM, Cross JC, Leaman DW (1991). Unique features of the trophoblast interferons. Pharmacology and Therapeutics 51:329-345 14. Roberts RM, Leaman DW, Cross JC (1992). Role of interferons in maternal recognition of pregnancy in ruminants. Proceedings for the Society of Experimental Biology and Medicine 200:7-18 15. Leaman DW, Cross JC, Roberts RM (1992). Genes for the trophoblast interferons and their distribution among mammals. Reproduction, Fertility and Development 4:349-353 16. Roberts RM, Cross JC, Leaman DW (1992). Interferons as hormones of pregnancy. Endocrine Reviews 13:432-452 17. Cross JC, Wen P, Rutter WJ (1993). Transactivation by HBV X-protein is promiscuous and dependent on mitogen activated, cellular serine-threonine kinases. Proceedings of the National Academy of Sciences U.S.A. 90:8078-8082 18. Leaman DW, Cross JC, Roberts RM (1994). Multiple regulatory elements are required to direct trophoblast interferon (IFN- ) gene expression in choriocarcinoma cells and embryonic trophectoderm. Molecular Endocrinology 8:456-468 19. Cross JC, Werb Z, Fisher SJ (1994). Implantation and the placenta: key pieces of the development puzzle. Science 266:1508-1518 20. Cross JC, Flannery ML, Blanar MA, Steingrimsson E, Jenkins NA, Copeland NG, Rutter WJ, Werb Z (1995). Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Development 121:2513-2523 21. Chen M, Tomkins DJ, Auerbach W, McKerlie C, Youssoufian H, Liu L, Gan O, Carreau M, Auerbach A, Groves T, Guidos CJ, Freedman MH, Cross J, Percy DH, Dick JE, Joyner AL, Buchwald M (1996). Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia. Nature Genetics 12:448-451 22. Cross JC (1996). Trophoblast function in normal and preeclamptic pregnancy. Fetal and Maternal Medicine Review 8:57-66. 23. Nakayama H, Liu Y, Stifani S, Cross JC (1997). Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the NOTCH-2 pathway. Developmental Genetics 21:21-30 24. Caniggia I, Lye SJ, Cross JC (1997). Activin is a local regulator of cytotrophoblast cell differentiation. Endocrinology 138:3976-3986 25. Rinkenberger J, Cross JC, Werb Z (1997). Molecular genetics of implantation in the mouse. Developmental Genetics 21:6-20 26. Riley P, Anson-Cartwright L, Cross JC (1998). The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Nature Genetics 18:271-275
  8. 8. James C. Cross... 8 27. MacAuley A, Cross JC, Werb Z (1998). Reprogramming the cell cycle for endoreduplication in rodent trophoblast cells. Molecular Biology of the Cell 9: 795-807 28. Nakayama H, Scott IC, Cross JC (1998). The transition to endoreduplication in trophoblast giant cells is regulated by the mSNA zinc-finger transcription factor. Developmental Biology 199:150-163 29. Copeman J, Bangia N, Cross JC, Cresswell P (1998). Elucidation of the genetic basis of the antigen presentation defects in the mutant cell line .220 reveals polymorphism and alternative splicing of the Tapasin gene. European Journal of Immunology 28:3783-3791 30. Cheng AM, Saxton TM, Sakai R, Kulkarni S, Mbamalu G, Vogel W, Totorice CG, Cardiff RD, Cross JC, Muller WJ, Pawson AJ (1998). Mammalian Grb2 regulates multiple steps in embryonic development, lineage commitment and malignant transformation. Cell 95:793-803 31. Cross JC (1998). Formation of the placenta and extraembryonic membranes. Annals of the New York Academy of Sciences 857:23-32 32. Cross JC, Lam S, Yagel S, Werb Z (1999). Defective induction of the transcription factor ISGF3 and interferon- insensitivity in human trophoblast cells. Biology of Reproduction 60:312-321 33. Hunter PJ, Swanson BJ, Haendel MA, Lyons GE, Cross JC (1999). Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development. Development 126:1247-1258 34. Damsky CH, Zhou Y, Genbacev O, Cross J, Fisher SJ (1999). Adhesion receptors: critical effectors of trophoblast differentiation during implantation and placentation. Advances in Molecular and Cell Biology 28:389-408 35. Basyuk E, Cross JC, Corbin J, Nakayama H, Hunter PJ, Nait-Oumesmar B, Lazzarini RA (1999). The murine Gcm1 gene is expressed in a subset of placental trophoblast cells. Developmental Dynamics 214:303-311 36. Janatpour MJ, Utset MF, Cross JC, Rossant J, Dong J, Israel MA, Fisher SJ (1999). A repertoire of differentially expressed transcription factors that offers insights into mechanisms of human cytotrophoblast differentiation. Developmental Genetics 25:146-157 37. Wang Y, Penfold S, Tang X, Hattori N, Riley P, Harper JW, Cross JC, Tyers M (1999). Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E. Current Biology 9:1191-1194 38. Scott IC, Anson-Cartwright L, Riley P, Reda D, Cross JC (2000). The Hand1 basic helix-loop- helix transcription factor regulates trophoblast differentiation via multiple mechanisms. Molecular and Cellular Biology 20:530-541 39. Goldman-Wohl DS, Ariel I, Greenfield C, Hochner-Celnikier D, Cross JC, Fisher SJ, Yagel S (2000). Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsia. Molecular Human Reproduction 6:88-95 40. Janatpour M, McMaster M, Genbacev O, Zhou Y, Dong J, Cross JC, Israel M, Fisher SJ (2000). Id-2 regulates critical aspects of human cytotrophoblast differentiation, invasion and migration. Development 127:549-558
  9. 9. James C. Cross... 9 41. Copeman J, Han RNN, Caniggia I, McMaster M, Fisher SJ, Cross JC (2000). Posttranscriptional regulation of human leukocyte antigen G during human extravillous cytotrophoblast differentiation. Biology of Reproduction 62: 1543-1550 42. Hattori N, Davies TC, Anson-Cartwright L, Cross JC (2000). Periodic expression of the Cdk inhibitor p57Kip2 in trophoblast giant cells defines a G2-like gap phase of the endocycle. Molecular Biology of the Cell 11:1037-1045 43. Anson-Cartwright L, Dawson K, Holmyard D, Fisher SJ, Lazzarini RA, Cross JC (2000). The Glial cells missing-1 gene is essential for branching morphogenesis in the chorioallantoic placenta. Nature Genetics 25:311-314 44. Riley PR, Gertsenstein M, Dawson K, Cross JC (2000). Early exclusion of Hand1-deficient cells from distinct regions of the left ventricular myocardium in chimeric mouse embryos. Developmental Biology 227:156-168 45. Cross JC (2000). Genetic insights into trophoblast differentiation and placental morphogenesis. Seminars in Cell and Developmental Biology. 11:105-113 46. Cross JC (2000). The fetus doesn’t accept complements. Pediatric Research 48:1 47. Hemberger M, Cross JC (2001). Genes governing placental development. Trends Endocrinology and Metabolism 12:162-168 48. Hudson JW, Kozarova A, Cheung P, Macmillan J, Swallow C, Cross JC, Dennis JW (2001). Late mitotic failure in mice lacking Sak, a polo-like kinase. Current Biology 11: 441-446 49. Saxton TM, Cheng AM, Ong S-H, Lu Y, Cross JC, Pawson AJ (2001). Gene dosage dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis. Current Biology 11:662-670 50. Cross JC (2001). Factors affecting the developmental potential of cloned mammalian embryos. Proceedings of the National Academy of Sciences, USA. 98:5949-5951 51. Rossant J, Cross JC (2001). Placental development: lessons from mouse mutants. Nature Reviews Genetics 2:538-548 52. Wang J, Mager J, Chen Y, Schneider E, Cross JC, Nagy A, Magnuson T (2001). Imprinted X- inactivation maintained by a mouse Polycomb group gene. Nature Genetics 28:371-375 53. Hemberger M, Cross JC, Ropers HH, Lehrach H, Fundele R, Himmelbauer H (2001). UniGene cDNA array-based monitoring of transcriptosome changes during mouse placental development. Proceedings of the National Academy of Sciences, USA 98:13126-13131 54. Cross JC (2001). Genes regulating embryonic and fetal survival. Theriogenology 55:193-207 55. Adamson SL, Lu Y, Whitely KJ, Holmyard D, Hemberger M, Pfarrer C, Cross JC (2002). Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta. Developmental Biology 250:358-373 56. Cross JC, Anson-Cartwright L, Scott IC (2002). Transcription factors underlying the development and endocrine functions of the placenta. Recent Progress in Hormone Research 57: 221-234
  10. 10. James C. Cross... 10 57. Cross JC, Hemberger M, Lu Y, Nozaki T, Whiteley K, Masutani M, Adamson SL (2002). Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta. Molecular and Cellular Endocrinology 187:207-212 58. Smart N, Hill AA, Cross JC, Riley PR (2002). A differential screen for putative targets of the bHLH transcription factor Hand1 in cardiac morphogenesis. Mechanisms of Development 119 (Suppl 1):S65-71. 59. Shingo T, Gregg C, Enwere E, Fujikawa H, Hassam R, Geary C, Cross JC, Weiss S (2003). Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin. Science 299:117-120 60. Cross JC, Baczyk D, Dobric N Hemberger M, Hughes M, Simmons DG, Yamamoto H, Kingdom JCP (2003). Genes, development and evolution of the placenta. Placenta 24:123-130 61. Cross JC, Simmons DG, Watson ED (2003). Chorioallantoic morphogenesis and formation of the placental villous tree. Annals of the New York Academy of Sciences 995:84-93 62. Takahashi Y, Carpino N, Cross JC, Torres M, Parganas E, Ihle JN (2003). SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation. EMBO J 22:372-384 63. Wu L, de Bruin A, Starovic M, Saavedra HI, Trimboli A, Yang Y, Opavska J, Wilson P, Ostrowski MC, Weinstein M, Rosol TJ, Cross JC, Robinson ML, Leone G (2003). Rb function in the placenta is essential for embryonic development and viability. Nature 421:942-947 64. Hemberger M, Nozaki T, Yamamoto H, Nakagama H, Kamada N, Suzuki H, Winterhager E, Masutani M, Cross JC (2003). Parp1-deficiency induces differentiation of ES cells into trophoblast derivatives. Developmental Biology 257:371-381 65. Hemberger M, Nozaki T, Masutani M, Cross JC (2003). Differential expression of angiogenic and vasodilatory factors by invasive trophoblast giant cells depending on depth of invasion. Developmental Dynamics 227:185-191 66. Austin KJ, Bany BM, Belden EL, Rempel LA, Cross JC, Hansen TR (2003). Interferon- Stimulated Gene-15 (Isg15) expression is upregulated in the mouse uterus in response to the implanting conceptus. Endocrinology 144:3107-3113 67. Cross JC (2003). The genetics of preeclampsia: a feto-placental or maternal problem? Clinical Genetics 64:96-103 68. Teng GQ, Zhao X, Cross JC, Li P, Lees-Miller JP, Guo J, Dyck JRB, Duff HJ (2004). Prolonged repolarization and triggered activity induced by adenoviral expression of HERG N629D in cardiomyocytes derived from stem cells. Cardiovascular Research 61:268-77 69. Baczyk D, Satkunaratnam A, Nait-Oumesmar B, Cross JC, Kingdom JCP (2004). Complex patterns of GCM1 mRNA and protein in villous and extravillous trophoblast cells of the human placenta. Placenta 25:553-559 70. Cross JC, Coan PM, Fundele R, Hemberger M, Kibschull M, Ferguson-Smith A (2004). Genes and Development Workshop Report. Trophoblast Research 25S:S39-S41
  11. 11. James C. Cross... 11 71. Zhao S-H, Simmons DG, Cross JC, Scheetz TE, Casavant TL, Soares MB, Tuggle CK (2004). PLET1, A highly expressed and processed novel gene in pig and mouse placenta is transcribed but poorly spliced in human. Genomics 84:114-125 72. Hughes M, Dobric N, Scott IC, Su L, Starovic M, Kingdom JCP, Cross JC (2004). The Hand1, Stra13 and Gcm1 transcription factors override FGF signaling to promote terminal differentiation of trophoblast stem cells. Developmental Biology 271:26-37 73. Hemberger M, Hughes M, Cross JC (2004). Trophoblast stem cells differentiate in vitro into trophoblast giant cells with invasive capacity. Developmental Biology 271:362-371 74. Cetin I, Foidart J-M, Miozzo M, Raun T, Jansson T, Tsatsaris V, Reik W, Cross J, Hauguel-de- Mouzon S, Illsley N, Kingdom J, Huppertz B (2004) Fetal growth restriction: a workshop report. Placenta 25:753-757 Submitted Refereed Papers 1. Gabor JY, Su L, Reguly T, Cross JC. Fzr/Cdh1 promotes the transition from mitotic cell cycles to endoreduplication in trophoblast giant cells. Submitted to Journal of Biological Chemistry 2. Hughes M, Hemberger M, Starovic M, Weinstein M, Cross JC. Activin mediates negative feedback from trophoblast giant cells to suppress differentiation of trophoblast stem cells. In preparation Published Books or Monographs None Collective Works and Book Chapters 1. Roberts RM, Cross JC, Farin CE, Kramer KK, Schalue-Francis TK, Hansen TR (1990). Trophoblast interferons as anti-luteolysins. In: Establishment of a Successful Human Pregnancy (RG Edwards, ed) Serono Symposia from Raven Press, New York 66:257-268 2. Roberts RM, Cross JC, Farin CE, Farin PW, Kramer KK, Francis H, Librach C, Fisher SJ (1991). Trophoblast interferons. In: Growth Factors in Reproduction. (DW Schomberg, ed) Serono Symposia from Springer-Verlag, New York pp. 235-245 3. Roberts RM, Klemann SW, Leaman DW, Bixby JA, Cross JC, Hansen TR (1991). The polypeptides and genes for ovine and bovine trophoblast protein-1. In: Proceedings of the International Ruminant Reproduction Symposium. Journal of Reproduction and Fertility Supplement 43:3-12 4. Scott IC, Cross JC (1999). Transcription factors and trophoblast cell lineage. In: Embryo Implantation: Molecular, Cellular and Clinical Aspects (D Carson, ed). Springer-Verlag, New York, pp.167-181 5. Cross JC (1999). Molecular regulation of placental development. In: Intrauterine Growth Restriction: Aetiology and Management. Baker PN, Kingdom JCP (eds). Springer-Verlag, London. pp.387-400
  12. 12. James C. Cross... 12 6. Cross JC, Anson-Cartwright L, Hattori N, Nakayama H, Riley P, Scott IC, Fisher SJ, Watson AJ, Stewart F (2000). Basic HLH transcription factors and differentiation of the trophoblast lineage in rodents, ruminants and horses. In: Cloned Animals and Placentation. Roberts RM, Yanagimachi R, Kariya T, Hashizume K (eds). Yokendo, Tokyo. 7. Cross, J. C. (2000). The mouse as a model for investigation of placental function. In The Placenta: Basic Science and Clinical Practice, J. C. P. Kingdom, E. R. M. Jauniaux, and P. M. S. O'Brien, eds. (London, RCOG Press), pp. 51-60. 8. Cross JC, Rossant J (2001). Development of the embryo. In: Textbook of Fetal Development. Bocking A, Harding R (eds). Cambridge University Press, Cambridge UK. pp 1-16 Invited Lectures Samuel Lunenfeld Research Institute, University of Toronto, October 1993 University of Calgary, Department of Medical Biochemistry, November 1993 Cornell University, Department of Veterinary Pathology, December 1993 Southern Alberta Gamete Society, University of Calgary, January 1994 Hospital for Sick Children, University of Toronto, January 1994 University of Colorado-Boulder, Department of Molecular, Cellular and Developmental Biology, February 1994 Gordon Conference: Gametogenesis and Embryogenesis, “Transcriptional Control of Trophoblast Differentiation”, August 1994 Loeb Institute, Ottawa Civic Hospital, “Genetic Control of Trophoblast Development”, February 1995 Tox Talx - Updates on the Pathology of Preeclampsia, “Genetic Control of Trophoblast Development”, San Francisco, June 1995 University of Toronto, Department of Medical Genetics, June 1995 Perinatal Research Society, “Implantation and the Placenta: Key Pieces of the Development Puzzle”, Cape Cod, September 1995 Maternal-Placental-Fetal Dialogue, "Genetic Control of Mouse Trophoblast Development," Maui, Hawaii, February 1996 13th Rochester Trophoblast Conference, “Induction of EVT Cell Differentiation from Villous Cytotrophoblast Cells in Culture,” Banff, Alberta, September 1996 13th Rochester Trophoblast Conference, “What and Where Are the Factors That Control Trophoblast Development and Behaviour?” Banff, Alberta, September 1996 13th Rochester Trophoblast Conference, “Helix-loop-helix Transcription Factors in Cell Proliferation Versus Differentiation Decisions,” Banff, Alberta, September 1996 Hospital for Sick Children, Department of Genetics, University of Toronto, November 1996 University of Western Ontario, Department of Physiology, February 1997 University of Toronto, Departments of Clinical Biochemistry and Pathology, April 1997 CRRA, University of Montreal, April 1997 Centre for Cardiovascular Research Scientific Day, University of Toronto, May 1997 Tox Talks, San Francisco, June 1997 1997 FASEB Summer Research Conference - Perinatal Regulation of the Cardiovascular System, August 1997 Havemeyer Foundation Symposium - Trophoblast Differentiation. Edinburgh. September 1997 Morphogenesis: Cell-Cell and Cell-Matrix Interactions, Bethesda, MD, October 1997 Serono Foundation - Molecular and Cellular Aspects of Periimplantation Processes, October 1997 University of Alberta, Perinatal Research Centre, December 1997 University of Calgary, Department of Medical Biochemistry, December 1997 Hospital for Sick Children, Department of Cardiovascular Research, University of Toronto, February 1998
  13. 13. James C. Cross... 13 Wayne State University, April 1998 University of Guelph, Chappel Memorial Lecturer in Biomedical Sciences, June 1998 Department of Zoology, University of Toronto, September 1998 International Workshop on “Embryogenesis and Implantation”, Hawaii, February 1999 University of Texas Medical Center-Houston, Department of Biochemistry, February 1999 German Society of Endocrinology, Plenary Lecture, Kiel, March 1999 Ottawa General Hospital Research Institute, April 1999 University of Texas at Dallas-Southwestern Medical Center, April 1999 University of California-San Diego, June 1999 International Congress on “The Cell Biology of Reproduction”, Cambridge UK, July 1999 Symposium on “Genomic Functions and Molecular Mechanisms in Embryogenesis and Development”, Tokyo Japan, October 1999 University of Tokyo, October 1999 Lake Shirakaba Conference of Biology of Pregnancy, Nagano Japan, October 1999 Royal College of Obstetricians and Gynaecologists, London UK, October 1999 University of Western Ontario, Department of Physiology, November 1999 University of Calgary, Department of Biochemistry, November 1999 McGill University, Department of Obstetrics and Gynaecology, February 2000 IRCM, University of Montreal, February 2000 Max Planck Institute for Human Genetics, Berlin, February 2000 University of Essen, Germany, February 2000 Workshop on “Trophoblast Invasion”, Bleyerheide, Netherlands, February 2000 University of Aachen, Germany, February 2000 Endocrine Society Meeting, Symposium Speaker, June 2000 Gordon Conference: Gametogenesis and Embryogenesis, July 2000 Gordon Conference: Reproductive Tract Biology, July 2000 Children’s Hospital Research Institute, Ohio State University, October 2000 International Symposium on Basic HLH Transcription Factor Genes, Amsterdam, Netherlands, November 2000 International Embryo Transfer Society, Symposium Speaker, Omaha, January 2001 Genes & Development Research Group Symposium, University of Calgary, March 2001 International Workshop on the Development and Function of Reproductive Organs, Israel, May 2001 Canadian Federation of Biological Sciences, Symposium Speaker, Ottawa, Canada, June 2001 Society for the Study of Reproduction, Symposium Speaker, Ottawa, Canada, July 2001 National Academy of Sciences (USA) Study on Human Cloning, Invited Speaker, August 2001 European Placental Group, Keynote Lecturer and Symposia Speaker, Sorrento, Italy, September 2001 BC Cancer Centre, January 2002 University of Texas at San Antonio, January 2002 Northwestern University, February, 2002 Texas A&M University, March 2002 MRC Imprinting and Growth Symposium, London UK, April 2002 Jackson Labs, Bar Harbor, Maine, April 2002 Cardiovascular Research Group, University of Calgary, May 2002 International Society for the Study of Hypertension During Pregnancy, Toronto, June 2002 Cold Spring Harbor Mouse Genetics Course, June 2002 Gordon Research Conference on Reproductive Tract Biology, New London CT, July 2002 Serono Symposium on Implantation, July 2002 Albert Einstein College of Medicine, New York, August 2002 Monash University, Melbourne Australia, October 2002 International Federation of Placental Associations Meeting, Melbourne Australia, October 2002 Population Genomics Research Group, University of Calgary, November 2002 Perinatal Research Centre, University of Alberta, February 2003 IRCM, University of Montreal, March 2003
  14. 14. James C. Cross... 14 University of Colorado Health Sciences Centre, April 2003 Conference on Female Reproductive Tract Biology, Germany, June 2003 Cold Spring Harbor Mouse Genetics Course, June 2003 Gordon Research Conference on Hormone Action, New Hampshire, July 2003 NIH Workshop (NIDA) Placental Proteins, Drug Transport and Fetal Development, Washington DC, August 2003 European Placental Group, Mainz Germany, September 2003 Burnham Institute, San Diego CA, January 2004 University of North Carolina, Department of Genetics, February 2004 University of Manitoba, March 2004 Imperial College-London, March 2004 Novartis Foundation Meeting – Biology of Trophoblast, London, March 2004 FASEB “Experimental Biology 2004” Meeting, Washington DC, April 2004 IRCM, Montreal, April 2004 Washington State University, April 2004 Wood’s Hole “Frontiers in Reproduction” Course lecture, June 2004 Placental Association of the Americas 2004 Meeting, Asilomar CA, September 2004 University of Missouri-Columbia, September 2004 Greenwald Symposium, Kansas City MO, October 2004 New England Perinatal Research Conference, Chatham MA, October 2004 University of Pennsylvania, October 2004 Abstracts Presented 1. Cross JC, Rutter LM, Manns JG (1985). Effects of naloxone and progesterone on LH secretion in the postpartum beef cow. Society for the Study of Reproduction, Montreal 2. Cross JC, Roberts RM (1988). An interferon produced by elongating porcine embryos. Society for the Study of Reproduction, Seattle 3. Schalue-Francis TK, Cross JC, Keisler D, Sikes JD, Roberts RM (1989). Bovine interferon alpha-1 increases pregnancy rates in ewes. Society for the Study of Reproduction, Columbia 4. Hansen TR, Cross JC, Farin CE (1989). Rates of transcription, mRNA degradation and synthesis of oTP-1. Society for the Study of Reproduction, Columbia 5. Cross JC, Farin CE, Sharif SF, Roberts RM (1989). Interferon and interferon regulatory factor-1 are present in placental tissue during pregnancy in mice. The Endocrine Society, Seattle 6. Cross JC, Li J, Farin CE, Roberts RM (1990). Differential expression of bovine interferon- subclasses in early embryos and virus induced leukocytes. American Society for Biochemistry and Molecular Biology, New Orleans 7. Hansen TR, Bixby JA, Leaman DW, Cross JC, Mathialagan N, Roberts RM (1990). Isolation and sequence of genes for bovine trophoblast protein-1. Society for the Study of Reproduction, Knoxville 8. Cross JC, Hansen TR, Bixby JA, Roberts RM (1990). Interferon-r II and trophoblast interferon (TP-1) promoters possess distinct sequences, patterns of inducible expression and affinities for transcription factors. International Society for Interferon Research, San Francisco
  15. 15. James C. Cross... 15 9. Leaman DW, Cross JC, Roberts RM (1990). Species distribution of genes for the trophoblast interferons and gene sequence conservation among ruminants. International Society for Interferon Research, San Francisco 10. Roberts RM, Cross JC, Leaman DW (1991). Cell-specific expression of the trophoblast interferons. International Society for Interferon Research, Nice 11. Leaman DW, Cross JC, Roberts RM (1992). Identification of regions of the trophoblast IFN gene promoter involved in expression in choriocarcinoma cells. Society for the Study of Reproduction, Raleigh 12. Cross JC, Leaman DW, Rutter WJ, Roberts RM (1992). Developmentally regulated transactivators interact with the trophoblast interferon promoter. International Society for Interferon Research, Toronto 13. Cross JC (1994). Transcriptional mechanisms controlling trophoblast cell development and function. Ontario/Quebec Perinatal Investigators Meeting, Kingston 14. Cross JC, Flannery ML, Blanar MA, Werb, Z (1994). Hxt encodes a basic helix-loop-helix transcription factor that regulates development of placental trophoblast cells. American Society for Cell Biology, San Francisco 15. Yagel S, Goldman-Wahl D, Fisher SJ, Cross J (1995). Regulation of HLA-G expression: promoter analysis in JEG-choriocarcinoma cells. Society for Gynecologic Investigation, Chicago 16. Cross JC, MacAuley A (1995). Checkpoints begone: transition in control of DNA synthesis during differentiation and onset of endoreduplication in trophoblast cells in vitro. Great Lakes Mammalian Development Meeting, Toronto 17. Cross JC (1995). Transcriptional control of trophoblast differentiation. Great Lakes Mammalian Development Meeting, Toronto 18. Cross JC, Scott I, Nakayama H, Anson-Cartwright L (1996). Genetic control of mouse trophoblast development. The Maternal-Placental-Fetal Dialogue, Maui 19. Cross JC, MacAuley A (1996). Transition in control of DNA synthesis during differentiation and onset of endoreduplication in trophoblast cells in vitro. The Maternal-Placental-Fetal Dialogue, Maui 20. Scott IC, Cross JC (1996). Basic helix-loop-helix factors Hxt and Mash-2 have distinct expression patterns and partner preferences during murine trophoblast development. Society for the Study of Reproduction 1996 Meeting, London, Ontario 21. Nakayama H, Scott IC, Cross JC (1996). Potential role of Notch/HES signaling in regulation of murine trophoblast differentiation and Mash-2 expression. Society for the Study of Reproduction 1996 Meeting, London, Ontario 22. Cross JC, Riley P, Anson-Cartwright L (1996). Mutation of the Hxt helix-loop-helix transcription factor gene results in early embryonic lethality. Mouse Molecular Genetics Meeting, Cold Spring Harbor 23. Caniggia I, Lye SJ, Cross JC (1996). Activin regulates cytrophoblast differentiation in first trimester human villous explant cultures. The 13th Rochester Trophoblast Conference, Banff, Alberta
  16. 16. James C. Cross... 16 24. Riley P, Cross JC (1997). Analyzing the function of Hxt in placental and cardiac development. Great Lakes Mammalian Development Meeting. Toronto 25. Copeman J, Cross JC (1997). Expression of antigen presenting molecules in the developing human placenta. Great Lakes Mammalian Development Meeting. Toronto 26. Nakayama H, Cross JC (1997). HES expression in placenta. Great Lakes Mammalian Development Meeting. Toronto 27. Hunter P, Cross JC (1997). Gene trapping identifies a new gene expressed in trophoblast cells. Great Lakes Mammalian Development Meeting. Toronto 28. Scott IC, Cross JC (1997). Regulation of basic helix-loop-helix activity during murine trophoblast cell development. Great Lakes Mammalian Development Meeting. Toronto 29. Riley P, Anson-Cartwright L, Cross JC (1998). The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Keystone Symposium on Cardiovascular Biology 30. Hunter PJ, Swanson BJ, Haendel MA, Lyons GE, Cross JC (1998). Mrj encodes a DnaJ-related chaperone that is essential for murine placental development. Great Lakes Mammalian Development Meeting. Toronto 31. Scott IC, Cross JC (1998). Regulation of basic helix-loop-helix activity during murine trophoblast cell development. Great Lakes Mammalian Development Meeting. Toronto 32. Riley P, Anson-Cartwright L, Cross JC (1998). The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Mouse Genetics Meeting, Cold Spring Harbor 33. Cross JC (1999). Genetic regulation of trophoblast differentiation. International Workshop on “Embryogenesis and Implantation”, Hawaii 34. Cross JC (1999). Genetic regulation of trophoblast differentiation. German Society of Endocrinology, Plenary Lecture, Kiel, March 1999 35. Hattori N, Davies T, Cross JC (1999). Regulation of p57Kip2 during the endocycle in trophoblat giant cells. Great Lakes Mammalian Development Meeting. Toronto 36. Scott IC, Cross JC (1999). Regulation of basic helix-loop-helix activity during murine trophoblast cell development. Great Lakes Mammalian Development Meeting. Toronto 37. Cross JC (1999). Genetic regulation of trophoblast differentiation. International Congress on “The Cell Biology of Reproduction”, Cambridge UK, July 1999 38. Cross JC (1999). Genetic control of placental development. Symposium on “Genomic Functions and Molecular Mechanisms in Embryogenesis and Development”, Tokyo 39. Cross JC (1999). Genetic control of placental development. Lake Shirakaba Conference of Biology of Pregnancy, Nagano Japan 40. Cross JC (1999). Molecular control of placental development. Royal College of Obstetricians and Gynaecologists, London UK
  17. 17. James C. Cross... 17 Kip2 41. Hattori N, Davies T, Cross JC (2000). Periodic expression of the Cdk inhibitor p57 in trophoblast giant cells defines a G2-like gap phase of the endocycle. Great Lakes Mammalian Development Meeting. Toronto 42. Scott IC, Cross JC (2000). The Hand1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms. Great Lakes Mammalian Development Meeting. Toronto 43. Anson-Cartwright L, Dawson K, Holmyard D, Fisher SJ, Lazzarini RA, Cross JC (2000). The Glial cells missing-1 gene is essential for branching morphogenesis in the chorioallantoic placenta. Great Lakes Mammalian Development Meeting. Toronto 44. Cross JC (2000). Molecular control of trophoblast cell development. Endocrine Society Meeting, Toronto 45. Nozaki T, Masutani M, Cross JC, Ochiya T, Nakagama H, Suzuki H, Sugimura T (2001). Development of trophoblast giant cells (TGCs) in teratocarcinoma-like tumors derived from Parp-1 - disrupted mouse ES cells. 5th Joint Conference of the AACR and Japanese Cancer Association. Maui, Hawaii 46. Dobric N, Kingdom J, Cross JC (2001). Coordinating the effects of proliferation and differentiation signals in murine trophoblast. Placenta 22:A21 47. Baczyk D, Kingdom J, Han R, Cross JC (2001). Glial cell missing 1 (gcm1) expression in the human placenta. Placenta 22:A24 48. Cross JC, Lu Y, Hemberger M, Adamson SL (2001). Invasion of the mouse uterus by distinct trophoblast subtypes. Placenta 22:A24 49. Hemberger M, Hughes M, Yamamoto H, Cross JC (2001). Murine trophoblast stem cells differentiate into invasive giant cells in vitro. Placenta 22:A21 ** no longer tracked

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