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    • - ` Part I: General Information DATE PREPARED: 2-10-10 Name: Lynne Lipton Levitsky Office Address: Pediatric Endocrine Unit Massachusetts General Hospital 55 Fruit Street Boston, MA 02114 Home Address: 165 Tremont Street, # 1703 Boston, MA 02111 E-Mail: Llevitsky@partners.org FAX: 617-726-3044 Place of Birth: Columbia, SC Education: 1962 B.A., cum laude with honors in biology Bryn Mawr College 1966 M.D., cum laude Yale University School of Medicine Postdoctoral Training: 1966-67 Intern in Pediatrics Bronx Municipal Hospital Bronx, NY 1967-68 Resident in Pediatrics Children's Hospital Philadelphia, of Philadelphia PA 1968-70 Fellow in Pediatric University of Maryland Baltimore, Endocrinology and School of Medicine MD Metabolism Licensure and Certification: 1971-2008 California License 1989- Massachusetts License 1971 Diplomate, American Board of Pediatrics 1978 Diplomate, American Board of Pediatrics Sub-Board in Pediatric Endocrinology Academic Appointments: 1970-73 Assistant Professor Pediatrics Abraham Lincoln School of Medicine, U. of Illinois 1973-78 Assistant Professor Pediatrics Pritzker School of Medicine, University of Chicago 1978-85 Associate Professor Pediatrics Pritzker School of Medicine, University of Chicago 1
    • 1985-89 Professor of Pediatrics Pritzker School of Medicine, University of Chicago 1990- Associate Professor of Pediatrics Harvard Medical School Hospital or Affiliated Institution Appointments: 1970-73 Pediatric Endocrinologist U. of Illinois Hospitals 1973-86 Medical Staff Michael Reese Hospital and Medical Center 1986-90 Medical Staff Wyler Children’s Hospital, University of Chicago 1986-90 Medical Staff La Rabida Children’s Hospital, University of Chicago 1990- Pediatrician Massachusetts General Hospital Other Professional Positions and Major Visiting Appointments: 1990-2005 Scientific and Medical Staff Shriners Burns Institute, Boston, MA 1990-96 Medical Staff Beverly Hospital, Beverly, MA 1996- Consultant Medical Staff Northshore Children’s Hospital, Salem, MA 2002-2003 Pediatric Endocrinologist Brigham and Women’s Hospital 2005- Pediatric Endocrinologist Cambridge Hospital Hospital and Health Care Organization Service Responsibilities: 1970-73 Pediatric Attending/Pediatric University of Illinois Endocrinologist Hospitals 1973-86 Pediatric Attending/Pediatric Michael Reese Hospital & Endocrinologist Medical Center 1986-89 Member, Section of Endocrinology Pritzker School of Medicine Department of Pediatrics University of Chicago Chicago, IL 1990- Pediatric Endocrinologist Massachusetts General Hospital 1990-96 Pediatric Endocrinologist Beverly Hospital, Beverly, MA 1996- Pediatric Endocrinologist Northshore Children’s Hospital, Salem, MA 1990- Pediatric Attending Massachusetts General Hospital Major Administrative Responsibilities: 1973-86 Director, Div. of Endocrinology Michael Reese Hospital & Med. Ctr. & Metabolism Chicago, IL 1973-86 Associate Director Michael Reese Hospital & Med. Ctr. Clinical Research Center Chicago, IL 1973-76 Director, Pediatric Microchemistry Michael Reese Hospital & Med. Ctr. Laboratory Chicago, IL 1983-86 Vice Chairman, Michael Reese Hospital & Med. Ctr. Department of Pediatrics Chicago, IL 2
    • 1983-90 Director, Pediatric Model Unit, Pritzker School of Medicine Diabetes Research & Training University of Chicago Center 1986-90 Head, Chicago Children's Diabetes La Rabida Children’s Center Hospital, Chicago, IL (Conceptualized, organized and developed this center – the only full service facility for the care of children with diabetes in Illinois) 1990- Chief, Pediatric Endocrine Unit Children’s Service, Massachusetts General Hospital, Boston, MA (MassGeneral Hospital for Children) 1993-96 Clinical Advisor, Pediatric Massachusetts General Hospital Microchemistry Laboratory 1994-96 Physician Liaison with Massachusetts General Hospital Pilgrim Health Care (Pediatrics) Major Committee Assignments: National: 1979 Site Visit Team, Brown University Member NIH/NICHHD School of Medicine 1981 Special Review Committee to Member NIH/NIDDK choose participants in Diabetes Control and Complications Trial 1982 Site Visit Team,University of New Member NIH/NIDDK Mexico 1982-85 Medical Science Advisory Board Member Juvenile Diabetes Research Review Committee Foundation 1985 Site Visit Team, Brown Member NIH/NICHHD University School of Medicine 1985 Site Visit Team, University of Member NIH/NICHHD Colorado School of Medicine 1986 Special Review Committee Member NIH/NIDDK Diabetes Control and Complications Trial 1986 Site Visit Team, Special Study Member NIH/NIDDK Section, Houston, TX 1986 Site Visit Team, Michigan DRTC Member NIH/NIDDK 1993 Ad Hoc Reviewer Member NIH/NICHHD 1996 NIH Site Visit Team, University of Member NIH/NICHHD Colorado School of Medicine 1996 Ad Hoc Reviewer, Initial Review Member NIH/NICHHD Group 1996 Ad Hoc Reviewer Member NIH/NICHHD HED-1 Study Section 1997, 98 American Academy of Pediatrics RepresentativeNIDDK/CDC Representative to National Diabetes Education Program Planning Conference 3
    • Bethesda, MD 1998 Pediatric Endocrine Society Member American Representative to Academy of Academy Pediatrics Task Force on of Pediatrics Subspecialty Representation 1998-2002 Special Grants Review Committee Member NIH/NIDDK Subcommittee B 2001-2003 Chair 1999-2000 Endocrinologic and Metabolic Consultant FDA Drugs Advisory Committee 2001-2004 Member 1999- Standing Panel, Accreditation Member Endocrinology Appeals in Pediatric Endocrinology ACGME EndocrinologyAccreditation 1999, 2003 Biologic Response Modifiers Member FDA/CBER Advisory Committee Meeting Human Islet Transplant Trials 2002,4 Endocrinology, Metabolism, Nutrition Ad Hoc member NIH/NIDDK & Reproductive Sciences Study Section ZRG1 SSS-T 10/02, 2/2004 2004- Editorial Board, American Academy of Pediatrics, PREP Self-Assessment 2005- Endocrine Metabolic Drugs Advisory Committee, FDA Consultant 2006- NIH/NIDDK special study section to review Ad Hoc member RFA-DK-05-014 The Obese and Diabetic Intrauterine Environment: Long-term Metabolic or Cardiovascular Consequences in the Offspring 2006 NIH/NIDDK Special Emphasis Panel/Scientific Review Group ZDK1 GRB-G to review K23 Ad Hoc member 2006 FDA Endocrine Metabolic Drugs Ad hoc consultant Advisory Meeting on L-Thyroxin Stability 2007 Special Emphasis Panel/Scientific Review Ad Hoc Chair Group ZDK1 GRB-4 M2 1, Training Grants 2008- Maintenance of Certification Committee Part IV LWPES American Board of Pediatrics,Quality Initiative, Representative Diabetes 2008- Diabetes Advocacy Consortium LWPES Representative See also committee and leadership activities for the Endocrine Society, the Academy of Pediatrics, and the Lawson Wilkins Pediatric Endocrine Society Regional: 1984-89 Research Committee Member American Academy of Pediatrics, Illinois Chapter 4
    • 1988-89 Executive Committee Member Chicago Pediatric Society Medical School: 1986-89 Clinical Research Center Member U. Chicago Advisory Committee 1988-89 Clinical Policy Committee Member U. Chicago 1988-89 Committee on Appointments Member U. Chicago and Promotions Affiliated Institutions: 1975-76 & Research Committee Member Michael Reese 1979-83 Hospital and 1982-83 Chair Med. Ctr. 1974-77 Clinical Research Committee Member Michael Reese 1976-77 Chair Hospital and Med. Ctr 1983-86 Medical Board Member Michael Reese Hospital and Med. Ctr 1990- Scientific Advisory Committee Member Massachusetts General Clinical Research Center General Hospital 1990-94 Subcommittee for the Review Member Massachusetts of Research Protocols General Hospital 1994-96 Children's Service Planning Member Pediatrics, Committee Massachusetts General Hospital 1994-96 Children's Service Shared Member Pediatrics, Management and Network Massachusetts Development Committee General Hospital 1994-96 Ad Hoc Children's Service Member Pediatrics, Research Committee Massachusetts General Hospital 1996- 2003 Junior Promotions Committee Member Pediatrics, Massachusetts General Hospital 2002-2006 ECOTE (Executive Committee on Elected Massachusetts Teaching and Education) Member General Hospital 2004- Quality Assurance in Diabetes Member Partners Task Force Health Care 2007- MGH Representative to Pediatric CTSA/C Harvard Medical School Professional Societies: Year Society Role 5
    • 1972- American Academy of Pediatrics Fellow (Committee Assignments as Noted under National) 1998 Endocrine Section RVU work group Chair, ICD representative 1970- American Diabetes Association Physician Member 2001 Speaker on Management of Childhood Diabetes-National Meeting 2002 Speaker in Debate on Screening for Celiac Disease –National Meeting 2003 Chair of Session on New Treatments for Pediatric Diabetes 1980-93 Midwest Society for Pediatric Research Member Abstract reviewer, Chair of meeting sessions 1986-93 Central Society for Clinical Research Member 1978- Society for Pediatric Research Member 1979-87 Abstract reviewer and chair of meeting sessions 1988- American Pediatric Society Member Abstract reviewer and chair of meeting sessions 1978 - Endocrine Society Member Abstract reviewer, chair of meeting sessions 1999-01 Special Programs Committee Member 2000 Symposium –New Developments Chair in the Management of Diabetes Mellitus in Children 2006-Clinical Guidelines Committee 1978 - Lawson Wilkins Pediatric Endocrine Member Society 1984-87 Diabetes Committee Member 1987 Chair 1990-94 Education Committee Member 1994 Chair 1996-99 Executive Council Director 1997- 2002 American Academy of Liason Pediatrics Section on Endocrinology and Lawson Wilkins Pediatric Endocrine Society 2001- Professional and Clinical Member Affairs Committee 2004-2007 Steering Committee, Clinical Research Network 2004 President Elect, Lawson Wilkins Pediatric Endocrine Society 2005 President, Lawson Wilkins Pediatric Endocrine Society 2006 Immediate Past President, Lawson Wilkins Pediatric Endocrine Society 2007-8 Member, Board of Directors, Lawson Wilkins Pediatric Endocrine Society 2009- Chair, Education Council of the LWPES 6
    • Community Service Related to Professional Work: 1973 -85 Medical Advisor Medical Human Growth Advisor Foundation, Illinois Chapter 1978-89 Board of Directors Member American Diabetes Association, Northern Illinois Affiliate 1975-89 Speaker Panel, Speaker American Diabetes Parent Child Education Association, Northern Illinois Affiliate 1990- Occasional Speaker Speaker American Diabetes Family Education Day Association, Mass Affiliate 2002 Keynote Speaker Speaker Prader Willi Association of New England 2006 Turner Syndrome Education Speaker Turner Syndrome Society of Day New England Editorial Boards: Year Role Name of Journal (Ad Hoc Reviews go back into the 1970’s, but I have not kept formal records!) 1996- Ad hoc Reviewer Diabetes Care 1997,8 Ad hoc Reviewer J. Ped. Gastroenterol and Nutrition 1997- Ad hoc Reviewer Am J. Physiol: Endo Metab 1997- Ad hoc Reviewer Pediatrics 1996,7 Ad hoc Reviewer Pediatric Research 1997- Ad hoc Reviewer Metabolism 1997- Ad hoc Reviewer J. Clinical Endo Metab 1997- Ad hoc Reviewer Am J. Physiol:Regulatory, Integrative and Comparative Physiology 1998- Ad hoc Reviewer Endocrinology 2000- Ad hoc Reviewer Diabetes 2002- Ad hoc Reviewer New England J. Med 2003- Ad hoc Reviewer J Pediatrics 2003- Ad hoc Reviewer Pediatric Diabetes 2004- Editorial Board J. Clinical Endo Metab 2007- Associate Editor Current Opinion in Endocrinology, Diabetes, Growth and Development and Obesity, Williams and Wilkins 2008- Associate Ediotor J. Pediatric Endocrinol Metab Awards and Honors: 1965 Alpha Omega Alpha, Yale Chapter 1985 Mary Jane Kugel Award, Juvenile Diabetes Foundation International (For 7
    • service on MSRC) 2004 President, Lawson Wilkins Pediatric Endocrine Society Part II: Research, Teaching, and Clinical Contributions: A. Narrative Report: I am a pediatric endocrinologist with a special interest in diabetes and metabolism. My focus has been on provision and improvement of clinical care in diabetes and in training of the next generation of thought leaders in the field. Over the course of my career I have organized and participated in national clinical conferences on Cerebral Edema in Diabetic Ketoacidosis, Management of Childhood Diabetes, Celiac Disease and Diabetes Mellitus, and Metabolic Syndrome and Type 2 Diabetes. I have spoken on these topics and other endocrine topics both nationally and internationally as an invited speaker, and as requested at courses organized by the American Academy of Pediatrics, and Harvard Primed continuing education. I serve as a member of the editorial board of the PREP (Pediatric Review examination group for the Academy of Pediatrics, providing content in Pediatric Endocrinology and contributing to the overview of content in all aspects of pediatrics). Nationally, I have served as President of the Lawson Wilkins Pediatric Endocrine Society and continue leadership roles in this organization. I am now serving as LWPES liason to a multi-organizational group that is attempting to rationalize provision of diabetes care in this country. In addition, I serve on a group that will work on Strategic Planning for this organization for the next 5 years. I also am on the Editorial Board of the Journal of Clinical Endocrinology and Metabolism, the Journal of Pediatric endocrinology and Metabolism and am the Editor of the Pediatric Section of Current Comments in Endocrinology, Metabolism and Diabetes. I have also had an active research career, working in the basic laboratory on aspects of carbohydrate metabolism in fetal and neonatal life, and now on developing an understanding of the function of the pancreatic beta cell in order to reconstruct it in a cell less likely to sustain autoimmune damage in individuals with type 1 diabetes mellitus. Several recent publications describe this work. I have trained 8 fellows and summer student research associates in the laboratory at Massachusetts General Hospital. My clinical research work presently is related to the development and conduct of the TODAY study, an NIH-funded trial of treatments for type 2 diabetes in children and Adolescents. I am the Associate Director of the study at the Massachusetts General Hospital-Boston site. I devote about 40% of my time to patient care and have developed the Pediatric Diabetes Center at the Massachusetts General Hospital, and clinical care center that is appropriately staffed to care for children with the most difficult of chronic endocrine diseases. I also have a special interest in hypothalamic-pituitary disorders and in growth disorders and focus on these areas in my clinical care. Essentially all of my patient care activities are also used as educational sites by fellows, resident, and medical students. Since arriving at MGH, I have trained 23 fellows in the clinical care of patients with endocrine disorders, and of those that have graduated, 15/18 remain in academic positions. I look forward to continuing national and international work in diabetes and pediatric endocrinology, as well as continuing research into the treatment of type 1 diabetes, and a continuing career as an educator and clinician on the local level. 8
    • B. Funding Information:* *All research except as noted (T = teaching, R = Research, C = Clinical) Year Funding Source P.I./Co-P.I. Grant Title 1971 BRSG U. Ill. P.I. Cerebral Ketone Body Utilization in the Baboon Neonate 1974-79 USPHS P.I. Functional Maturation of the Endocrine Pancreas 1975-78 USPHS P.I. Energy Metabolism in the Fetus and Neonate 1977-80 USPHS (Pilot P.I. Pathophysiologic Correlations in Experi- Project, DRTC) mental Autoimmune Diabetes Mellitus 1979-83 USPHS P.I. Metabolism in the Subhuman Primate and Ovine Fetus 1983-90 USPHS P.I. Pediatric Model Unit of DRTC, A. Rubenstein, P.I. for DRTC (T, R, C) 1983-84 Cambridge Quest P.I. The Effect of Altered Nutritional Regimens Foundation upon Glycemic Control in Children with Insulin-dependent Diabetes Mellitus 1984-93 USPHS P.I. Metabolism in the Nonhuman Primate and Ovine Fetus 1985-87 JDRF P.I. Mechanism of Glycogenesis in the Fetus 1990-91 Shriners P.I. Burn Stress: Is Interleukin-1 the trigger for the Neuroendocrine Response? 1991-93 Shriners P.I. Regeneration of Adipose Tissue after Severe Burn Injury: Clinical and Experimental Studies 1993-94 MGH Interim P.I. Metabolism in the Fetal Hepatocyte Support Fund 1995-95 Genentech Fndtn P.I. The Effect of Growth Hormone upon for Growth & Develop. Human Adipogenesis 1994-95 Genentech Fdtn. Consultant Culturally Sensitive Educational Materials for Growth & Develop. On Growth and Development for the Ethnic Cambodian Population 1995-96 Genentech Fdtn. P.I. The Effect of Growth Hormone upon for Growth & Develop. Human Muscle Glucose Transport 1994-96 Genentech, Inc. P.I. Pubertal Changes in Growth Hormone Treated Patients 1994-96 Genentech Fdtn. Co. I. MIS during Sexual Maturation for Growth & Develop. 1995-97 Genentech Fdtn. P.I. The Effect of Growth Hormone upon for Growth & Develop. Human Adipocyte Glucose Transport 1995- 97 Novo-Nordisk P.I. Human Muscle Glucose Transport: Effect of GH and IGF-1 9
    • 1993- Genentech, Inc. P.I. Effect of GH upon Statural Growth and Body Composition in Children with Prader- Willi Syndrome 1996-2001 USPHS P.I. Metabolism in the Fetal Hepatocyte HD31215 1997-99 Genentech Fdtn. P.I. Bone Metabolism in Anorexia Nervosa- Fellowship Dr. Leslie Soyka 2000-01 Genentech Center Consultant Obsesive Compulsive Disorder in Turner for Clinical Research Syndrome and Education 2000-2003 USPHS Co-Invest. Transcriptional Control of Carbohydrate DK54399 Responsive Genes (P.I. David B. Rhoads) 2000-2002 USPHS Harvard - Mentor Bone Metabolism and Training grant in growth factors in Anorexia Nervosa - Academic Nutrition Fellowship Madhusmita Misra, M.D. 2001-2003 USPHS NIDDK DRC P.I. Islet Function in mice with selective loss Pilot Project of HNF1beta in Beta cells 2001-2003 USPHS NIDDKPilot Project P.I. Antecedents of adult insulin resistance in human infants 2002-2008 USPHS NICHD Co-P.I. TODAY study (Treatment trial for Type 2 D. Nathan, P.I. Diabetes in Childhood) 2002-2008 USPHS NICHD, co-invest Effects of Anorexia on Peak Bone Mass A. Klibanski, P.I. 2005-2008 Genentech, Inc. P.I. Growth hormone and insulin resistance in girls with Turner Syndrome or idiopathic short stature 2005-2008 Pfizer, Inc. P.I. Growth hormone and insulin resistance in children with intrauterine growth restriction 2005-2008 ADA Co-Invest Role of HNF1beta in Beta Cell David B. Rhoads, P.I. Development 2009.2011 Harvard P.I. Noninvasive Measurement of Hydration Catalyst Not funded C. Report of Current Research Activities: Project Role Role of HNF1Beta in Beta Cell Development Co-Investigator Effects of Anorexia Nervosa on Peak Bone Mass Co-Investigator TODAY study (Treatment Trial for Type 2 DM) Co-Investigator (funded 20%) Growth Hormone and insulin resistance in children PI with intrauterine growth restriction Patents: Method of enhancing Native Promoter activity: Provisional Patent Applied for (Huang, Levitsky, Rhoads) 10
    • D. Report of Teaching: 1. Local Contributions a. Continuing Inpatient House Officer and Medical Student Teaching 1970-73 Ward Attending, General Pediatrics (3 mos/yr) and Attending Pediatric Endocrinologist (6 mos/yr), University of Illinois Hospital 1973-86 Ward Attending, General Pediatrics, Michael Reese Medical Center (3mos/yr) 1973-86 Attending Pediatric Endocrinologist, Michael Reese Medical Center (6-11 mos/year) 1973-86 Outpatient teaching throughout year in diabetes and endocrinology clinics at above institutions. Organizer of curriculum for endocrinology at Michael Reese Medical Center 1986-89 Attending Pediatric Endocrinologist, Wyler Children's Hospital (3 mos/yr) 1986-89 Associate Attending in Pediatric Endocrinology, La Rabida Children's Hospital 1990- Attending in Pediatric Endocrinology, Massachusetts General Hospital (HMS Clerkship PD 507 M.3, 2-4 students/year) – Organizer of course experience. Contact time 10 –20 hr/wk 1994- 2006 Attending in Pediatrics, Massachusetts General Hospital, ½ - 1 mo/yr c. Local Invited Teaching presentations: Presentations at home institution at least 10 times/year since 1970 (1 hour grand rounds or other formal didactic contributions) At Massachusetts General Hospital: 1990- Grand Rounds in Pediatrics and approximately every other year 1990- 6-10 formal 1 hour presentations in Pediatric Endocrinology didactic or clinical conferences, or Chief of Service Rounds and didactic conferences in Pediatrics yearly on various Endocrine topics. d. Continuing Medical Education Each of these talks requires 10 hours or so of preparation 1970-92 Yearly speaker at Cook County Graduate School Courses in Pediatrics, Family Practice, Critical Care and Diabetes Education 1987 Organized Endocrine component of Advances in Pediatrics Course, Cook County Graduate School-20 hours of preparation 1970-89 Approximately 10-12 talks yearly to professional groups in the Indiana and Northern Illinois area on assorted endocrine topics 1990-yearly Regional talks in the greater Boston area 1991-yearly Speaker Post Graduate Course in Primary Care Pediatrics, Massachusetts General Hospital, Harvard Medical School 1995,6,2008,9 Speaker Academy of Pediatrics National CME Meetings 11
    • 2001- Speaker at Pediatric Emergency Medicine Conference, Massachusetts General Hospital, Harvard Medical School 2004, 2006 Speaker at Harvard Primed Conference2004 2008 Harvard Primed Conference Mexico City, Mexico e. Advisory and supervisory responsibilities in clinical and laboratory setting: 1990- Precepting residents, fellows as previously described in ambulatory and inpatient setting. f. Teaching leadership Role in Department/affiliated Institution 1975.86 Director, Pediatric Endocrine Training Program, Michael Reese Hospital and Medical Center 1990- Director, Pediatric Endocrine Training Program, Massachusetts General Hospital g. Advisor and Supervisory Responsibilities Fellowship Trainees: As Director of Pediatric Endocrine Training Program, Michael Reese Medical Center 1975-77 Nives Dumbovic, M.D. - faculty, Rush Medical School, Pediatric Endocrinologist , Chicago, IL 1977-79 Deborah V. Edidin, M.D. - faculty, Northwestern University Medical School, Division of Pediatric Endocrinology 1978-80 Nancy E. Friedman, M.D. - faculty, Duke University School of Medicine, Division of Pediatric Endocrinology As Member of Training Program Attending Staff, Wyler Children's Hospital 1986-89 Mary Kreiter, M.D., faculty Rush Medical School, Division of Pediatric Endocrinology As Director of Pediatric Endocrine Training Program, Massachusetts General Hospital 1990-91 Lauren Frisch, M.D., Pediatric Endocrinologist, Pittsburgh, PA 1991-92 Kristina Rother, M.D., Research Associate, National Institutes of Health 1992-96 David Zangen, M.D.,Chief, Pediatric Endocrinology, Hadassah Hospital, Jerusalem, Israel 1993-96 Nejib Raboudi, M.D., Pediatric Endocrinology, Tunis, Tunisia 1994-97 Cecilia Capriles, M.D., Pediatric Endocrinology, Caracas, Venezuela 1994-98 Karen Loechner, M.D., Ph.D., Faculty,Pediatric Endocrinology, University of North Carolina 12
    • 1996-99 Andrew Lane, M.D., Faculty, Pediatric Endocrinology, S.U.NY., Stonybrook 1996-99 Leslie Soyka, M.D., Faculty, Pediatric Endocrinology, U. Mass Medical Center 1998- 2001 Robert Gensure, M.D., Ph.D. Chief, Pediatric Endocrinology, Tulane University School of Medicine 1999- 2002 Madhusmita Misra, M.D. Faculty, Harvard Medical School, Massachusetts General Hospital 2000-2003 Christopher P. Houk, M.D.Faculty, Pediatric Endocrinology, Medical College of Georgia 19982001-2004 Elaine C. Moreland, M.D., Faculty, University of Alabama 19992002-2005 Tandy Aye, M.D. Faculty, Stanford University 20002003-2004 Angel Guacaneme, M.D., Fellow in Pediatric Endocrinology, St. Jude’s 2001 Memphis TN 2004-2006 Clemens Bergwitz, M.D., Faculty, Endocrinology, MGH, Harvard Medical School 2004.2007Elka Jacobson-Dickman, M.D, faculty, SUNY Downstate Medical 2002 Center, Brooklyn NY 20032004-2007 Rajani Prabhakaran, M.D., Pediatric Endocrinologist, Austin, Texas 20042005- Jennifer Sivitz, M.D., Fellow in Pediatric Endocrinology 20052005- Ximena Lopez, M.D., Fellow in Pediatric Endocrinology 20062005- Elvira Isganaitis, M.D., MPH. Fellow in Pediatric Endocrinology 20072006- Melissa Woo, M.D., Fellow in Pediatric Endocrinology 20082006- Takara Stanley, M.D., Fellow in Pediatric Endocrinology 20092006-2008 Tamara Wexler, M.D., Fellow in Adult Endocrinology 20102007- Vi Nguyen, M.D., Fellow in Pediatric Endocrinology 20112008- Melissa Russell, M.D. Fellow in Pediatric Endocrinology 20122008- Sharon Straussman, M.D., Fellow in Pediatric Endocrinology 20132008- Michelle Katz, M.D., Fellow in Pediatric Endocrinology 20142009- Deborah Mitchell, M.D., Fellow in Pediatric Endocrinology 2015 Eray Savgan-Gurol, M.D., Fellow in Pediatric Endocrinology 2016As Director of Pediatric Endocrine Research Laboratory, Massachusetts General Hospital: 1990.1997 Qingjun Zheng, M.D. Research Fellow, presently Pediatrician, St. Vincent’s Medical Center, New York, NY These students are now all physicians in training or in practice or academic positions: 1993 Tamara Cochran, 1st year Medical Student, Columbia P&S Society for Pediatric Research Summer Research Student 1993 Jennifer Lightdale, 3rd Yr Medical Student, Mount Sinai Medical School Society for Pediatric Research Summer Research Student (Competed fellowship in Pedi GI- Harvard Combined Program) 1995 Savita Mohan 1st Yr Medical Student, New York University School of Medicine, Society for Pediatric Research Summer Research Student 2002 Sarah Unterman 1st yr medical student, LWPES summer student research fellowship 13
    • 2003 Tal Minor 1st yr Medical Student, Cornell, Soc Pediatric Research Summer Research Student 2003 Ganiu Eddu 1st yr Medical Student, U. Illinois, LWPES summer student research fellowship 2007 Amanda Leonberger Society for Pediatric Research, Summer Research Student, 1st yr Medical Student, Creighton University 2. a. Regional, National or International Contributions Oct. 1982 Thyroid Disease in Pediatric Patients. 7th Annual Postgraduate Program, American Thyroid Association June 1984 Diabetes Mellitus Modern Management. Illinois Academy of Pediatrics May 1985 Diabetes in Childhood. Schaffran Memorial Lecture, Aurora, IL March 1986 Hypoglycemia. Leon Librik Memorial Lecture, University of Illinois, Peoria, IL Jan. 1987 New Aspects of Diabetes Management. Chicago Pediatric Society March 1987 Diabetes Mellitus in Children and Adolescents. Chicago Medical Society, Midwest Clinical Conference April 1987 Cerebral Edema in Diabetic Ketoacidosis. Symposium, Lawson Wilkins Pediatric Endocrine Society, Society for Pediatric Research May 1989 Diabetic Ketoacidosis. Lawson Wilkins Pediatric Endocrine Society, Diabetes Symposium, Society for Pediatric Research Oct. 1989 Evaluation of the Metabolic Effects of Hypoglycemia in Human Infants and Non-human primates. Ciba Foundation Discussion Group on Neonatal Hypoglycemia, London, England Oct. 1989 Mortality from Diabetic Ketoacidosis. Hospital Saint-Vincent de Paul, Paris Oct. 1989 Treatment of Diabetic Ketoacidosis. International Study Group of Diabetes in Children and Adolescents, Bled, Yugoslavia Apr 1990 Role of the Pediatrician in the Prevention of Complications of Diabetes, St. Barnabas Medical Center, New Jersey Jan 1991 Diabetic Ketoacidosis, Yale New Haven Medical Center June 1991 Cerebral Metabolism and Hypoglycemia in the Newborn, Progress in Neonatology. IX International University Children's Clinic Symposium, Vienna, Austria June 1992 Neonatal Endocrine Emergencies - Pediatric Endocrine Nurses Society Aug 1992 Lectures - Review in Pediatrics, National Center for Advanced Medical Education, Chicago, IL Sept 1992 Diabetes Update, Chicago Pediatric Society Nov 1993 Diabetes Ketoacidosis, Mamonides Medical Center, Pediatric Endocrinology Course, Brooklyn, NY April 1995 Seminar, Office Management of Diabetes Mellitus, Academy of Pediatrics Spring Meeting, Phila, PA May 1995 Prevention of the Complications of Diabetes Mellitus, Newer Metabolic Aspects of Diabetes Mellitus, Serono Symposium 14
    • Lawson Wilkins Pediatric Endocrine Society, San Diego, CA June 1995 Update on Diabetes Management, Cook County Hospital Grand Rounds, Chicago, IL June 1995 Diabetes Update, Beverly Hospital Grand Rounds, Beverly, MA May 1996 Office Management of Diabetes Mellitus in Children, Northshore Children's Hospital, Salem, MA October 1996 Seminar, Office Management of Diabetes Mellitus, Academy of Pediatrics Annual Meeting, Boston, MA April, 1997 Update on Diabetes Mellitus, Grand Rounds, University of Illinois Medical Center Nov,1997 Pitfalls in Pediatric Endocrinology, CoChair, U. Athens, Athens, Greece June, 2000 Meet the Professor Session, Diabetic Ketoacidosis in Children, Endocrine Society, Toronto, Canada June, 2001 Meet the Professor Session, Diabetic Ketoacidosis in Children, Endocrine Society Meeting June, 2001 Speaker, Session on Management of Childhood Diabetes, American Diabetes Association. Jan, 2002 Endocrine Grand Rounds, Brown University, Experiences with Childhood Cushing’s Disease Mar, 2002 Pediatric Endocrine Rounds, Boston Children’s Hospital, Childhood Cushing’s Disease Mar, 2002 Grand Rounds, Holy Family Hospital, Endocrine Emergencies May, 2002 Grand Rounds, Newton Wellesley Hospital, Bone Health in Childhood and Adolescence May, 2002 Grand Rounds, Northshore Medical Center, Pituitary Tumors in childhood June, 2002 Speaker, Session on Management of Childhood Diabetes:Screening for Celiac Disease, American Diabetes Association Sept, 2002 Keynote Speaker, New England Pediatric Endocrine Nurses Organization, Congenital Adrenal Hyperplasia Oct, 2002 Grand Rounds, Holy Family Hospital, Type 2 Diabetes Oct, 2002 Speaker, Academy of Pediatrics Annual Meeting, Boston, Type 2 Diabetes Mellitus Nov, 2002 Speaker, Department of Pediatrics, Mt. Sinai Hospital and Medical School, New York, Diabetes Conference, Type 2 Diabetes Oct, 2003 Grand Rounds, Northshore Medical Center, Childhood Type 2 diabetes Oct, 2003 Alfred S. Traisman Memorial Lecturer, Children’s Memorial Hospital, Northwestern U., Chicago, IL, Type 2 Diabetes in Childhood Nov, 2003 Grand Rounds, Lawrence General Hospital, The Epidemic of Childhood Obesity and Type 2 Diabetes Feb, 2004 Grand Rounds, Lawrence General Hospital, Diabetic Ketoacidosis May, 2004 Grand Rounds, Newton Wellesley Hospital, Type 2 Diabetes in Children and Adolescents Oct, 2004 Obesity and Type 2 diabetes in Adolescents, Blue Cross/Blue Shield Panel on Childhood Obesity Oct, 2004 Type 2 Diabetes and Metabolic Syndrome, Chelsea Health Center Oct, 2004 Transcription Factors and MODY Diabetes, Columbia University Pediatric Endocrine Rounds, New York, NY Oct 2004 Type 2 Diabetes, Harvard Primed, Boston Nov, 2004 Type 2 Diabetes in Children, Annual Pediatrics Day, Pinnacle Health Systems, 15
    • Harrisburg, PA Feb, 2005 Type 2 Diabetes and Metabolic Syndrome, East Boston Neighborhood Health Center Mar, 2005 Metabolic Syndrome and Type 2 Diabetes, Grand Rounds, Cambridge Hospital April, 2006 Presidential Address, Lawson Wilkins Pediatric Endocrine Society Oct, 2006 Metabolic Syndrome and Type 2 Diabetes, Harvard Primed, Boston Ocr, 2006 Metabolic Syndrome and Obesity, Endocrine Grand Rounds, Brown University Nov 2006 Short Stature, Endocrine Day, Department of Pediatrics, Flushing Hospital Medical Center Feb, 2007 Obesity and Type 2 Diabetes: TODAY study Update, Grand Rounds Univeristy of Massachusetts Medical Center April, 2007 Obesity and Type 2 Diabetes: The Big Picture, Grand Rounds Cambridge Hospital Yearly Participant in Massachusetts General Hospital Pediatrics Review Course and Pediatric Emergencies Course. Topics: Types 1 and 2 Diabetes, Thyroid disease, Endocrine Emergencies. b. Professional Leadership Roles Related to Teaching 1987 Preparation & Organization of Course on Complications of Diabetic Ketoacidosis for Lawson Wilkins Pediatric Endocrine Society 1994 Preparation and Organization of Serono Symposium, Molecular Biology for Endocrinologists for Lawson Wilkins Pediatric Endocrine Society 2003 One of the coordinators of a consensus conference on Diabetic Ketoacidosis – a joint project of the LWPES and the European Society of Pediatric Endocrinology 2005 As president of the LWPES helped to organize the program for the endocrine component of the PAS meetings. 2006- Editor, Growth and Development, For Current Opinion in Endocrinology Diabetes, and Obesity, Williams and Wilkins 2009-- Chief, Education Council of the Lawson Wilkins Pediatric Endocrine society—Tasked with providing and coordinating education resources for members and others in the field. E. Report of Clinical Activities 1. Clinical practice of pediatric endocrinology at Massachusetts General Hospital, Northshore Children’s Hospital, and Cambridge Hospital. 2. Patient Load – Approximately 25 outpatients/week, 2-3 months as inpatient attending 3. Clinical Contributions – Recognized as a consultant pediatric endocrinologist nationally (listed in the appropriate Best Doctor’s, etc for at least 15 yr). 16
    • Part III: Bibliography Original Articles 1. Miller ME, Seals J, Kaye R, Levitsky LL. A familial plasma-associated defect of phagocytosis: a new cause of recurrent bacterial infections. Lancet 1968; i:60-63. 2. Cornblath M, Levitsky LL, Kling A. Response to intravenous glucose in juvenile macaque monkeys: effect of central nervous system lesions and species differences. Diabetes. 1971; 20:156-161. 3. Beitins I, Bayard F, Levitsky LL, Ances IG, Kowarski A, Migeon CJ. Plasma aldosterone concentration at delivery and during the newborn period: effect of maternal sodium restriction. J Clin Invest. 1972; 51:386-394. 4. Firor HV, Moore ES, Levitsky LL, Galvez M. Parathyroidectomy in children with chronic renal failure. J Pediatr Surg. 1972; 7:565. 5. Raiti S, Trias E, Levitsky LL, Grossman M. Oxandrolone and human growth hormone: comparison of growth stimulating effect in short children. Am J Dis Child. 1973; 126:597-600. 6. Levitsky LL, Speck S, Shulman R. Metabolic response to fasting in experimental intra- uterine growth retardation: a comparison of two models. Biol. Neonate.1976; 30:11-16. 7. Garland JT, Jennings J, Levitsky LL, Buchanan F. Stimulation of DNA synthesis in isolated chondrocytes by somatomedin. II. Validation of the assay for clinical use and comparison with the stimulation of protein synthesis. J Clin Endo Metab. 1976; 43:847. 8. Levitsky LL, Fisher DE, Paton JB, de Lannoy CW. Fasting plasma levels of glucose, acetoacetate, D-§-hydroxybutyrate, glycerol, and lactate in the baboon infant: correlation with cerebral uptake of substrates and oxygen.Pediatr Res. 1977; 11:298-302. 9. Levitsky LL, Kimber A, Marchichow JA, Uehera J. Metabolic response to fasting in experimental intrauterine growth retardation induced by surgical and non- surgical maternal stress. Biol Neonate. 1977; 31:311-315. 10. Levitsky LL, Uehara JA, Marchichow JA, Dumbovic N. Glucagon response to arginine in growth hormone deficient children before and after treatment with growth hormone in children with non-endocrine short stature. Clinical Endocrinology.1978; 8:473-481. 11. Duquesnoy RJ, MacDonald MJ, Mullins T, Hackbarth SA, Traisman HS, Levitsky LL. Increased frequency of HLA-DW3 in North American black patients with juvenile onset diabetes. Tissue Antigens. 1979; 13:369-372. 12. Martin LG, Grossman MS, Connor TB, Levitsky LL, Clark JW, Camitta FO. Effect of androgen on growth hormone secretion and growth in boys with short stature. Acta Endocr. 1979; 91:201-212. 13. Edidin DV, Levitsky LL, Schey W, Dumbovic N, Campos A. Resurgence of nutritional rickets associated with breast feeding and special dietary practices. Pediatrics. 1980; 65:232-235. 14. Levitsky LL, Paton JB, Fisher DE, de Lannoy CW. Arterial blood levels of energy substrates and evidence for renal glucose production in the baboon infant. Pediat Res. 1980; 14:926-931. 15. Jennings J, Buchanan F, Levitsky LL, Garland JT. Growth hormone dependent human serum stimulation of thymidine and sulphate incorporation into embryonic chicken cartilage. Acta Endocr. 1980; 94:480. 16. Levitsky LL, Paton JB, Fisher De, de Lannoy CW. Uptake and release of energy substrates, oxygen, and carbon dioxide by the hindlimb of the fasting baboon. 17
    • Biol Neonate. 1981; 39:105-112. 17. MacDonald MJ, Traisman HS, Levitsky LL, Dequesnoy RJ, Mullins P, Hackbarth SA. HLA types in American Black juvenile diabetics: strong associations with Dw3 and Dw4. Metab. 1981; 30:533-536. 18. Friedman NE, Levitsky LL, Edidin DV, Vitullo DA, Lacina SJ, Chiemmongkoltip P. Echocardiographic evidence for impaired myocardial performance in children with type I diabetes mellitus. Am J Med. 1982; 73:846-850. 19. Brusilow SW, Danney M, Weber LJ, Batshaw M, Burton B, Levitsky L, Roth K, McKeethren C, Ward J. Treatment of episodic hyperammonemia in children with inborn errors of urea synthesis. N Eng J Med. 1984; 310:1630-1634. 20. Levitsky LL, Paton JB, Fisher DE, de Lannoy CW. Splanchnic uptake and release of energy substrates in the fasting infant baboon. Pediatr Res. 1984; 18:1316-1320. 21. Levitsky LL, Edidin DV, Mennella JA, Spaulding NH, Hseih L-C. The effect of dexamethasone and surgically induced intrauterine growth retardation on renal and hepatic levels of phosphoenolpyruvate carboxykinase in the rat. Biol.Neonate. 1986; 49:36-42. 22. Levitsky LL, Paton JB, Fisher DE, Spaulding NH, Paton AL. Gluconeogenesis from lactate in the chronically catheterized baboon fetus. Biol Neonate.1986; 50:97-106. 23. Baum VC, Levitsky LL, Englander RM. Abnormal cardiac function following exercise in young insulin dependent diabetics. Diabetes Care. 1987; 10:319-323. 24. Pinsky L, Kaufman M. Levitsky LL. Partial androgen resistance due to a distinctive qualitative defect of the androgen receptor. Am J Med Genetics.1987; 7:459-466. 25. Levitsky LL, Paton JB, Fisher DE. Precursors to glycogen in ovine fetuses. Am J Physiol. 1988; 255:E743-E747. 26. Schoeller DA, Levitsky LL, Bandini LG, Dietz WH, Walczak A. Energy expenditure and body composition in Prader-Willi Syndrome. Metabolism.1988; 37:115-120. 27. Schoeller DA, Bandini LG, Levitsky LL, Dietz WH. Energy requirements of obese children and young adults. Proceedings of the Nutrition Society. 1988; 47:241-246. 28.. Levitsky LL, Schoeller DA, Lambert GH, Edidin DV. The effect of growth hormone therapy in growth hormone deficient children on cytochrome P-450 dependent 3-N-demethylation of caffeine measured by the caffeine 13CO2 breath test. Dev Pharmacol Ther. 1989; 12:90-95. 29. Paton JB, Levitsky LL, Fisher DE. Placental transfer and fetal effects of maternal sodium beta-Hydroxybutyrate infusion in the baboon. Pediatr Res. 1989; 25:435-439. 30. Cuttler L, Jackson JA, uz-Zafor MS, Levitsky LL, Mellinger RC, Frohman LA. Hypersecretion of growth hormone (GH) and prolactin in McCune-Albright Syndrome. J Clin Endocrinol Metab. 1989; 68:1148-1154. 31. Ehrmann DA, Rosenfield RL, Cuttler L, Burstein S, Cara JF, Levitsky LL. A new test of combined pituitary-testicular function using the gonadotropin-releasing hormone agonist nafarelin in the differentiation of gonadotropin deficiency from delayed puberty. Pilot studies. J Clin Endocrinol Metab. 1989; 69:963-967. 32. Rosenfield RL, Burstein S, Cuttler L, Cara JF, Levitsky LL, Barnes RB, Ehrmann D: Use of nafarelin for testing pituitary-ovarian function. J Reprod Med. 1989;34:1044-1050. 33. Kreiter M, Burstein S, Rosenfield RL, Moll G, Cara JF, Yousefzadeh D, Cuttler L, Levitsky LL: Preserving adult height potential in girls with idiopathic true precocious puberty. J Pediat. 1990; 117:364-370. 34. Levitsky LL, Scanu AM, Gould SH: Lipoprotein (a) levels in black and white children 18
    • and adolescents with insulin dependent diabetes mellitus.Diabetes Care 1991; 14:283-287. 35. Zheng Q, Levitsky LL, Fan J, Ciletti N, Mink K: Glycogenesis in the fetal and adult rat hepatocyte is differently regulated by medium glucose. Pediat Res 1992; 32:714-718. 36. Cuttler L, Rosenfield RL, Ehrmann DA, Kreiter M, Burstein S, Care JF, Levitsky LL: Maturation of gonadotropin and sex steroid responses to gonadotropin- releasing hormone agonist in males. J Clin Endocrinol Metab 1993; 76:362-366. 36. Levitsky LL, Stonestreet BS, Mink K, Zheng Q: Glutamine carbon flux and glutamine uptake in the fetus of the fed and fasted ewe. Am J Physiol, 1993; 265:E722-E727. 37. Levitsky LL, Zheng Q, Rhoads DB, Mink K: GLUT-1 and GLUT-2 mRNA and glucose transporter activity in cultured adult and fetal hepatocytes. Am J Physiol 1994; 267:E88-E94. 38. Barnes RB, Rosenfield RL, Ehrmann DA, Cara JF, Cuttler L, Levitsky LL: Ovarian hyperandrogynism as a result of congenital adrenal virilizing disorders: Evidence for perinatal masculinization of neuroendocrine function in women. J Clin Endocrinol Metab, 1994; 79:1328-1333. 39. Zheng Q, Levitsky LL, Mink K, Rhoads DB: Glucose regulation of glucose transporters in cultured adult and fetal hepatocytes, Metabolism, 1995; 44:1553-1558. 40. Rhoads DB, Rosenbaum DH, Unsal H, Isselbacher KJ, Levitsky LL: Circadian periodicity of intestinal Na+/Glucose cotransporter 1 mRNA levels is transcriptionally regulated. J Biological Chem, 1998; 273:9510-9516. 41. Soyka LA, Grinspoon S, Levitsky LL, Herzog DB, Klibanski A: The effects of anorexia nervosa on bone metabolism in female adolescents. J. Clin Endocrinol Metab, 1999; 84:4489-4496. 42. Tavakkolizadeh A, Berger UV, Shen KR, Levitsky LL, Zinner MJ, Hediger MA, Ashley SW, Whang EE, Rhoads DB: Diurnal rhythmicity in intestinal SGLT-1 function, V(max) and mRNA expression topography, Am J Gastrointest Liver Physiol 2001; 280:G209-G215. 43. Misra M, Soyka LA, Miller KK, Grinspoon S, Levitsky LL, Klibanski A, Regional body Composition in adolescents with anorexia nervosa and changes with weight recovery, Am J Clin Nutr 2003;77:1361-7 44. Yang, F., T. Agulian, J. E. Sudati, D. B. Rhoads, and L. L. Levitsky. Developmental regulation of galactokinase in suckling mouse liver by the Egr-1 transcription factor. Pediatric Research 55: 822-829 (2004) 45. Wang, L., C. Coffinier, M. K. Thomas, L. Gresh, G. Eddu, T. Manor, L. L. Levitsky, M. Yaniv, and D. B. Rhoads. Selective deletion of the HNF1 β (MODY5) gene in β cells leads to altered gene expression and defective insulin release. Endocrinology 145:3941-9 46. Tavakkolizadeh A, Ramsanahie A, Levitsky LL, Zinner MJ, Whang EE, Ashley SW, Rhoads DB. Differential role of vagus nerve in maintaining diurnal gene expression rhythms in the proximal small intestine. J Surg Res. 129:73-8, 2005 46. Misra M, Levitsky LL, Intermittent growth attenuation: is this a sign of craniopharyngioma? J Pediatr Endocrinol Metab 19:1033-8, 2006 47. Huang J, Karakchuk V, Levitsky LL, Rhoads DB, Expression of HNF4α variants in pancreatic islets and Ins-1 β cells, Diabetes Metab Res Rev, 2008, 24: 533-543 48. McCormack S, Mitchell DM, Woo M, Levitsky LL, Ross DS, Misra M, Radioactive iodine treatment for hyperthyroidism in children and adolescents: referral rate and 19
    • response to treatment, Clin Endocrinol (Oxf) 71:884-891, 2009 49. Huang J, Levitsky LL, Rhoads DB, Novel P2 promoter-derived HNF4alpha isoforms with different N-terminus generated by alternate exon insertion, Exp Cell Res, 2009, 315:1200-11. 50. Stanley TL, Levitsky LL, Grinspoon SK, Misra M., Effect of body mass index on peak growth hormone response to provocative testing in children with short stature. J Clin Endocrinol Metab. 2009 4875-81. 51. Huang J, Levitsky L, Rhoads D, Enhancement of native promoters by introducing non- adjacent response-element multimers: Generation of regulated, specific and powerful promoters, submitted to Nucleic Acid Research Reviews, Chapters and Editorials: 1. Levitsky LL, Cornblath M. Hypoglycemia in childhood. In: Barnett HL, ed. Pediatrics, 15th Edition. New York: Appleton-Century Crofts, 1973:360-367. 2. Levitsky LL, Cornblath M. The infant of the diabetic mother. In: Fajans S., Sussman K., eds. Diabetes mellitus: diagnosis and treatment. Volume III. New York: Amer Diabetes Assoc Inc., 1971:243-246. 3. Levitsky LL, Edidin DV. Growth disorders in children. Comprehensive Ther. 1980; 6:22. 4. Edidin DV, Levitsky LL. Nutritional rickets in infancy. In: Lifshitz F., ed. Clinical disorders in pediatric nutrition. New York: Marcel Dekker, 1981;146-165. 5. Levitsky LL, Edidin DV. Diabetic ketoacidosis. In: Vidyasagar D., ed. Neonatal and pediatric intensive care. Littleton, MA: PSG Publishing Co., 1985;175-188. 6. Levitsky LL, Growth and pubertal patterns in insulin dependent diabetes mellitus (IDDM). Seminars in Adolescent Medicine. 1987; 3:233-239. 7. Baum VC, Levitsky LL. Echocardiographic evaluation of left ventricular function in asymptomatic adolescent diabetic patients. Practical Cardiology. 1987; 13:42.51. 8. Levitsky LL. Short stature. In: Dershewitz R., ed. Ambulatory pediatric care. Philadelphia: J.B. Lippincott Company, 1988; 334-339. 9. Levitsky LL. Short stature. In: Dershewitz R., ed. Ambulatory Pediatric Care. Philadelphia: J.B. Lippincott Company, 1992, 2nd edition; 334-340. 10. Rother KI, Levitsky LL. Diabetes mellitus during adolescence. Endo Metab 2017 Clinics of N. Am, 1993; 22:553-572. 2018 11. Axelrod L, Levitsky LL. Hypoglycemia. In: Kahn CR, Weir GC, eds., Joslin's Diabetes Mellitus, 1994:976-998. 12. Zangen D, Levitsky LL: Diabetes Ketoacidosis. In: Pugliese, Fort and Lifshitz, 20
    • eds., Pediatric Endocrinology, 3rd edition, 1995. 13. Raboudi N, Levitsky LL: Insulin Dependent Diabetes Mellitus. In: Burg FD, Ingelfinger JR, Wald ER, Polin RA, eds., Current Pediatric Therapy, 15th edition, 1995 and 16th ed.,1999 14. Lee MM, Levitsky LL; Tall Stature. In: Burg FD, Ingelfinger JR, Wald ER, Polin RA, eds., Current Pediatric Therapy, 15th edition, 1995 14. Capriles, C, Levitsky LL: Insulin-dependent Diabetes Mellitus. In: Finberg L, ed., Saunders Manual of Pediatric Practice, 1998 16. Loechner K, Levitsky LL: Thyroid Disorders. In Burg FD, Ingelfinger JR, Wald ER, Polin RA, eds., Current Pediatric Therapy, 16th edition, 1999 17. Levitsky LL. Short stature. In: Dershewitz R., ed. Ambulatory Pediatric Care. Philadelphia: J.B. Lippincott Company, 3nd edition;1999. 18. Levitsky LL. Diabetes mellitus. In: Dershewitz R., ed. Ambulatory Pediatric Care.Philadelphia: J.B. Lippincott Company, 3rd edition; 1999 19. Lee MM, Levitsky LL, Disorders of the Adrenal. In Burg FD, Ingelfinger JR, Wald ER, Polin RA, eds., Current Pediatric Therapy 17th edition., 2002 20. List JF, Levitsky LL, The epidemic of type 2 diabetes in children and adolescents, Endocrinology Rounds 1:issue 7, 2002 (www.endocrinologyrounds.org) 21. Houk CM, Levitsky LL, Ambiguous Genitalia, in Up to Date in Pediatrics, web-based and CD ROM based text, 2003, 2008 22 Aye, T, Levitsky LL. Diabetes Mellitus in Children and Adolescents, In: Rakel, Robert, Bope, Edward, eds Conn’s Current Therapy 56th Ed. Phildadelphia: Saunders, 2003. 23. Aye T, Levitsky, LL, Type 2 Diabetes: An epidemic disease in childhood, Current Opin Pediatr 15:411-415, 2003 24. Freemark, M., and L. L. Levitsky. Screening for celiac disease in children with Type 1 diabetes: Two views of the controversy. Diabetes Care 2003; 26: 1932-1939. 25. Dunger DB, Sperling MA, Acerini CL, Bohn DJ, Daneman D, Danne TP, Glaser NS, Hanas R, Hintz RL, Levitsky LL, Savage MO, Tasker RC, Wolfsdorf JI; European Society for Paediatric Endocrinology; Lawson Wilkins Pediatric Endocrine Society. European Society for Paediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society consensus statement on diabetic ketoacidosis in children and adolescents. Pediatrics. 2004 Feb;113(2):e133-40. (Dunger DB, Sperling MA, Acerini CL, Bohn DJ, Daneman D, Danne TP, Glaser NS, Hanas R, Hintz RL, Levitsky LL, Savage MO, Tasker RC, Wolfsdorf JI; ESPE; LWPES. ESPE/LWPES consensus statement on diabetic ketoacidosis in children and adolescents. Arch Dis Child. 2004 Feb;89(2):188-94.) 21
    • 26. Levitsky LL. Childhood immunizations and chronic illness. N Engl J Med. 2004 ; 350:1380-2 27. Levitsky LL, Symptomatic cerebral edema in diabetic ketoacidosis: the mechanism is clarified, but still far from clear, J Pediatr. 2004 145:149-150. 28. Prabhakaran R, Levitsky, LL, Diabetic Ketoacidosis, Pediatric Critical Care Medicine, Eds Slonim AD, Pollack MM, Lipincott 2006 29. Jacobson-Dickman E, Levitsky LL, Role of Oral Agents in the Management of Childhood Diabetes, Pediatric Clinics of North America, ed. M Sperling, 52:1689-703, 2005 Clinics of North America, ed. M Sperling 30. Levitsky, LL, Misra M, Associated Autoimmune diseases in children and adolescents with type 1 diabetes mellitus, Up To Date in Pediatrics, web-based and CD ROM based text, 2006, 2008 31. Levitsky, LL, Misra M, Complications and screening in children and adolescents with type 1 diabetes mellitus, Up To Date in Pediatrics, web-based and CD ROM based text, 2006, 2008 32. Levitsky LL, Misra M, Epidemiology, presentation, and diagnosis of type 1 diabetes mellitus in children and adolescents, Up To Date in Pediatrics, web-based and CD ROM based text, 2009 33. Levitsky LL, Misra M, Management of type 1 diabetes mellitus in children and adolescents, Up To Date in Pediatrics, web-based and CD ROM based text, 2006, 2008 34. Levitsky LL, Misra M, Special situations in children and adolescents with type 1 diabetes mellitus, Up To Date in Pediatrics, web-based and CD ROM based text, 2006, 2008 35. Levitsky LL, Cognitive dysfunction following treatment of Cushing’s syndrome, Nat Clin Pract Endocrinol Metab 2:666-7, 2006. 36. Levitsky LL, Defining the role of IGF-1 therapy for short children, J Clin Endocrinol Metab 92:813-4, 2007. 37. Lopez X, Levitsky LL, Hypoglycemia, Nutrition Handbook, Academy of Pediatrics, R Kleinman, ed, 2008 38. Rhoads D, Levitsky LL, Macronutrient Requirements for Growth: Carbohydrates, in Nutrition in Pediatrics: Basic Science and Clinical Applications, 4th edition, eds: Walker, Duggan, Watkins, 2008 39. Isganaitis E, Levitsky L, Preventing Childhood Obesity: Can we do it?, Current Opinion in Endocrinology, Diabetes and Obesity, 15:1-8, 2008 22
    • 40. Rhoads DB, Levitsky L, The function of HNF1 in the pathogenesis of diabetes, Expert Review of Endocrinology and Metabolism 2008, 3: 391-403. 41. Sherry N, Levitsky, L Management of diabetic ketoacidosis in children and adolescents. .Paediatr Drugs. 2008;10:209-15. 42. Levitsky LL, Misra M, Boepple PA, Hoppin AG, Adolescent obesity and bariatric surgery.Curr Opin Endocrinol Diabetes Obes. 2009 ;16:37-44. 42. Straussman S, Levitsky L, Neonatal Hypoglycemia, Current Opinion Endo, Diabetes, Obesity 17:20-24, 2010 Books, Monographs, and Text Books: 1. Proceedings, Growth hormone and growth factors in endocrinology and metabolism, 23rd International Symposium, eds. Camacho-Hubner C, Levitsky LL, Hughes I, de Zegher F, Gunnarsson R, Acta Pediatrica 86:Suppl 423, 1-217, 1997 Obesity in Childhood, Current Opinion in Endocrinology, Metabolism and Diabetes, ed. Levitsky L, 1 (1): 2008 Puberty and its Disorders, Current Opinion in Endocrinology, Metabolism and Diabetes, ed, Levitsky LL, 2009. Fetal and Neonatal Endocrinology, Current Opinion in Endocrinology, Metabolism and Diabetes, ed, Levitsky LL, 2010 Clinical communications 1. Levitsky LL, Trias E, Grossman M. Spontaneous thyrotoxicosis in infancy. Pediatrics. 1970; 46:627-629. 2. Friedman NE, Levitsky LL, Edidin DV. Choanal atresia and associated multiple anomalies. J Pediatr. 1980; 94:1123. 3. Edidin DV, Levitsky LL. Prepubertal gynecomastia associated with estrogen- containing hair cream. Am J Dis Child. 1982; 136:587-588 4. American Academy of Pediatrics (AAP), Sections on Endocrinology and Ophthalmology, Position Statement. Screening for Retinopathy in the Pediatric Patient with Type 1 Diabetes Mellitus. Pediatrics. 1998; 101:313. 5. Levitsky, L., Section Editor, Hormonal Disorders, Harvard Medical School Family Health Guide, ed.Komaroff, AL, Simon & Schuster, 1999 6. Levitsky, L, and Gensure R,Thyroid Disease, in Review of Pediatrics, eds Burg F, Nelson K, Vaughn V, WB Saunders, 2002 (Multiple choice and patient management questions with annotated discussion for a learning materials program) 7. Misra M, Levitsky LL, Lee MM, Transient hyperthyroidism in an adolescent with hydatidiform mole, J Pediatr 140:362-366, 2002 8. Israel EJ, Levitsky LL, Anupindi SA, Pitman MB, Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 3-2005. A 14-year-old boy with recent slowing of growth and delayed puberty. N Engl J Med 2005; 352:393-403. 23
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