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Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
Institute of Biological Research and Biotechnology (IBRB ...
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Institute of Biological Research and Biotechnology (IBRB ...

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  1.  
  2. National Hellenic Research Foundation Institute of Biological Research & Biotechnology <ul><li>Institute of Biological Research and Biotechnology (IBRB) established in 1977 </li></ul><ul><li>Aims at establishment: </li></ul><ul><ul><li>Advancement of fundamental research in Basic Biological Sciences, with emphasis on Biomedicine </li></ul></ul><ul><ul><li>Strengthening of infrastructure in above fields </li></ul></ul><ul><ul><li>Exploitation of results of fundamental research for applied research and biotechnology </li></ul></ul><ul><ul><li>Training of under graduates, graduates, post-doctoral researchers and technical and other personnel. </li></ul></ul>INSTITUTE PROFILE
  3. National Hellenic Research Foundation Institute of Biological Research & Biotechnology <ul><li>Fundamental research is grouped along three main research axes: </li></ul><ul><li>Molecular regulatory pathways of cell function in health, disease and ageing </li></ul><ul><li>Molecular and environmental toxicology and </li></ul><ul><li>Enzymes and proteins of biomedical and biotechnological interest. </li></ul>RESEARCH AXES
  4. National Hellenic Research Foundation Institute of Biological Research & Biotechnology <ul><li>Research Programmes have been developed within Axes - Distinct and specific interests but partially overlapping in aims and methodology: </li></ul><ul><li>Signal-regulated gene expression </li></ul><ul><li>Molecular endocrinology </li></ul><ul><li>RNA processing </li></ul><ul><li>Molecular and cellular ageing </li></ul><ul><li>Chemical carcinogenesis and genetic toxicology </li></ul><ul><li>Protein structure, function and regulation </li></ul><ul><li>Biomimetics </li></ul><ul><li>Enzymology </li></ul><ul><li>Biotechnology communication and bioethics </li></ul>RESEARCH PROGRAMMES
  5. National Hellenic Research Foundation Institute of Biological Research &Biotechnology <ul><li>Applications Units created during recent years, in order to promote applied projects and provision of R&D services to industry and other users. </li></ul><ul><li>Three Units have been established, based on the three Research Axes of the Institute: </li></ul><ul><ul><ul><li>Biomedical Applications Unit </li></ul></ul></ul><ul><ul><ul><li>Environmental Toxicology Unit </li></ul></ul></ul><ul><ul><ul><li>Industrial Enzymology Unit </li></ul></ul></ul>APPLICATION UNITS
  6. National Hellenic Research Foundation Institute of Biological Research &Biotechnology <ul><li>Unique activity among Greek Research Institutes </li></ul><ul><li>Public perception of biotechnology and associated bioethical problems </li></ul><ul><li>In line with current tendency of research institutes in most European countries and the USA </li></ul><ul><li>Establish a dialogue and awareness with the public, state organizations and other interested parties </li></ul><ul><li>Contribute to the information and the dialogue about biotechnology in Greece. </li></ul>BIOTECHNOLOGY COMMUNICATION & BIOETHICS
  7. National Hellenic Research Foundation Institute of Biological Research &Biotechnology Scientific Advisory Committee Institute Advisory Research Council Biomedical Application Unit Environmental Toxicology Unit Industrial Enzymology Unit Biotechnology communication And bioethics
  8. National Hellenic Research Foundation Institute of Biological Research &Biotechnology PERSONNEL 4 4 Researchers B 1 1 2 Researchers C 1 1 Researchers D 2 4 6 Researchers A 4 1 5 Technical personnel 3 3 Functional Scientific Personnel 6 9 15 Post-doc rese a rchers 2 12 1 15 Administrative & auxiliary personnel 5 35 39 79 Total 10 10 Other 20 18 Scientists & engineers under research training > 50 years 30-50 years < 30 years Age Total Type of personnel
  9. National Hellenic Research Foundation Institute of Biological Research &Biotechnology FINANCIAL STATEMENT ( million GRD)* ? 336.6 335.8 301.8 271.2 Salaries of regular personel PLUS telephones ? 590.2 513.4 451.1 438.2 EXPENDITURE Total 8.0 5.3 4.3 5.1 7.7 Product & services sales 17.5 9.6 12.3 6.0 7.6 C ontracts by firms 189 67.8 57.5 92.2 107.8 EU Framework Programme 233 189.1 89.9 95.3 106.5 Structural funds 56.3 13.3 - - - National projects & studies ? 336.6 338.4 302.6 285.4 R egular public budget ? 621.7 502.4 501.2 515.0 INCOME Total 2000 1999 1998 1997 1996
  10. National Hellenic Research Foundation Institute of Biological Research & Biotechnology FUNDING OF PERSONNEL - 20 - 24 - 22 other staff 16 - 8 18 - 20 post-graduate students/ trainee scientists 15 16 3 16 1 17 staff with Ph.D. external funding regular budget external funding regular budget external funding regular budget 1999 1995 1990
  11. National Hellenic Research Foundation Institute of Biological Research & Biotechnology NHRF external funding
  12. National Hellenic Research Foundation Institute of Biological Research & Biotechnology <ul><li>In collaboration with many Departments of Greek (and foreign) Universities, supervision of 37 PhD theses of science students (biologists, chemists, pharmacists) and medical doctors leading to Dr.med. </li></ul><ul><li>Training of TMR post-Doc fellows </li></ul><ul><li>Active involvement in organization of the Spetsai Summer Schools, many EMBO-FEBS Workshops, scientific meetings and round-table discussions. </li></ul><ul><li>Regular special seminars for the Ph.D. candidates and for medical personnel </li></ul><ul><li>Constant flow of scientific personnel to learn specific techniques and methodologies. </li></ul>TRAINING
  13. National Hellenic Research Foundation Institute of Biological Research & Biotechnology <ul><li>Fundamental research in targeted areas: </li></ul><ul><li>Biomedicine, Biotechnology and Environmental Health </li></ul><ul><li>Areas in which IBRB possesses expertise </li></ul><ul><li>Adaptation to specific targets </li></ul><ul><li>Projects exploited by the Application Units </li></ul><ul><li>Connected with the Greek Health and Industrial Sector </li></ul>RESEARCH AND TECHNOLOGY STRATEGY
  14. National Hellenic Research Foundation Institute of Biological Research & Biotechnology <ul><li>Structural and functional analysis of proteins involved in specific biochemical regulatory pathways in 4 important areas of cell biology. </li></ul><ul><ul><ul><li>Signal transduction </li></ul></ul></ul><ul><ul><ul><li>Post-transcriptional modification of hnRNA </li></ul></ul></ul><ul><ul><ul><li>Steroid receptors </li></ul></ul></ul><ul><ul><ul><li>Enzymes of glycogen metabolism </li></ul></ul></ul><ul><li>Temporal and spatial expression </li></ul><ul><ul><ul><li>Interaction with other biomolecules to form larger functional complexes in specific cells and tissues </li></ul></ul></ul><ul><li>Design effector molecules to modulate their activity </li></ul>DIRECTIONS (AREAS OF PRIORITY) (1)
  15. National Hellenic Research Foundation Institute of Biological Research & Biotechnology <ul><ul><ul><li>DIRECTIONS (AREAS OF PRIORITY) (2) </li></ul></ul></ul><ul><li>Structural and functional analysis of enzymes in: </li></ul><ul><ul><li>Protein phosphorylation </li></ul></ul><ul><ul><li>Oxidation processes, antioxidants, free radicals </li></ul></ul><ul><ul><li>Low water content restricted media - biomimetics </li></ul></ul>
  16. National Hellenic Research Foundation Institute of Biological Research & Biotechnology <ul><ul><ul><li>DIRECTIONS (AREAS OF PRIORITY) (3) </li></ul></ul></ul><ul><li>The role of genes in the ageing process </li></ul><ul><li>Effects of external and internal agents causing genetic instability connected to carcinogenesis </li></ul><ul><ul><li>Genes associated to longevity </li></ul></ul><ul><ul><li>DNA repair mechanisms </li></ul></ul><ul><ul><li>Factors affecting individual susceptibility </li></ul></ul><ul><ul><li>Assessment of carcinogenic risks </li></ul></ul>
  17. National Hellenic Research Foundation Institute of Biological Research & Biotechnology <ul><li>Pharmaceutical Industry </li></ul><ul><li>Medical Diagnostics </li></ul><ul><li>Food and Seed Industry </li></ul><ul><li>Environment - public health - connected public agencies </li></ul>RESULT EXPLOITATION - R+D SERVICES (1)
  18. National Hellenic Research Foundation Institute of Biological Research & Biotechnology <ul><li>Biomedical Application Unit </li></ul><ul><li>Novel diagnostics, predictive-prognostic services </li></ul><ul><li>Industrial Enzymology Unit </li></ul><ul><ul><ul><li>Enzyme applications in biotechnological application processes, analytical techniques, quality control </li></ul></ul></ul><ul><li>Unit of Environmental Toxicology </li></ul><ul><ul><ul><li>Focal center for systematic assessment of environmental toxicants </li></ul></ul></ul><ul><ul><ul><li>Scientific support for policy formulation in area of public health protection </li></ul></ul></ul>R+D SERVICES (2) - APPLICATION UNITS
  19. National Hellenic Research Foundation Institute of Biological Research & Biotechnology <ul><li>Research personnel </li></ul><ul><li>Increased staff due to extramural funding </li></ul><ul><li>Funds for R+D </li></ul><ul><li>All research conducted with competitive funding (175 MGRD/year = 520 KEuro/year). </li></ul><ul><li>Aver. income 1996-99 up by 65% compared to 1990-95 </li></ul><ul><li>During year 2000, expected income: 496 MGRD, up 100% compared to 1999 </li></ul><ul><li>Funds for provision of services </li></ul><ul><li>Health Sector - Breast cancer receptor assays since 1981 </li></ul><ul><li>Industrial Enzymology Unit - Services to Industry </li></ul><ul><li>GMO Detection Lab </li></ul>ASSESSMENT OF THE INSTITUTE’S POTENTIAL TO ATTRACT
  20. National Hellenic Research Foundation Institute of Biological Research & Biotechnology <ul><li>Advancement of biomedical research, applied research, education and training </li></ul><ul><li>Distinguished characteristics </li></ul><ul><li>Combination of basic research with the provision of innovation- based services </li></ul><ul><li>Critical mass of researchers in molecular regulatory pathways in cancer, autoimmune diseases and aging - collaboration with the Medical Community - Biomed Application Unit. </li></ul>PLACE OF INSTITUTE ON THE MAP OF R/T DEVELOPMENT ACTIVITIES (1)
  21. National Hellenic Research Foundation Institute of Biological Research & Biotechnology PLACE OF INSTITUTE ON THE MAP OF R/T DEVELOPMENT ACTIVITIES (2) <ul><li>Critical mass of researchers on protein/enzyme – structure function </li></ul><ul><li>Relevance to industrial applications (catalysis, enzyme inhibitors, etc) </li></ul><ul><li>Unique in systematic activity in Molecular Toxicology – Environmental Toxicology Unit – Risk assessment - Support of regulatory agencies </li></ul>

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