George P. Chrousos, MD

George P. Chrousos, MD CURRICULUM VITAE I. Biographical Information p. 2 II. Academic Honors and Awards p. 3 III. Membership in Professional and Scientific Organizations p. 5 IV. Membership in Committees - Editorial Boards - Society Boards p. 5

George P. Chrousos, M.D. I. BIOGRAPHICAL INFORMATION NAME: George P. Chrousos, M.D. PRESENT ADDRESS: Aiolou 12 Athens, Greece 15 342 DATE AND PLACE OF BIRTH: July 18, 1951; Patras, Greece CITIZENSHIP: United States, Greece DEGREES: M.D., Athens University, Faculty of Medicine, Athens, Greece, 1975 Sc.D., Athens University, Athens, Greece, 1977 Doctor Honoris Causa, Liege University, Liege, Belgium, 2003 Doctor Honoris Causa, Universita Politechnica delle Marche, Ancona, Italy 2006 BOARD CERTIFICATION: American Board of Pediatrics, 1980 American Board of Pediatric Endocrinology, 1980 Greek Specialty Title in Pediatrics, 1980 Greek Specialty Title in Endocrinology, 1981 POSITIONS HELD: Senior Investigator Developmental Endocrinology Branch (1981 - 1989) National Institute of Child Health and Human Development, NIH Chief, Pediatric Endocrinology Section Developmental Endocrinology Branch (1989 - 1999) National Institute of Child Health and Human Development, NIH Chief, Pediatric and Reproductive Endocrinology Branch (1999-2001), National Institute of Child Health and Human Development, NIH Professor and Chairman, First Department of Pediatrics, Athens University Medical School (2001- ) POSTGRADUATE TRAINING 1975-1980 1. 1975-1976 Research Fellow, Laboratory of Microbiology and Immunology, Athens University, Athens, Greece. 2. 1975-1976 Resident, First Department of Internal Medicine, Athens University, Faculty of Medicine, Athens, Greece. 3. 1976-1978 Resident, Department of Pediatrics, New York University Medical Center, New York, NY. 4. 1978-1981 Clinical Associate, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland. CERTIFICATION AND LICENSURE 1. 1975 License to practice Medicine in Athens, Greece 2

George P. Chrousos, M.D. 2. 1975 Educational Council for Foreign Medical Graduates (ECFMG); Standard Certificate. 3. 1977 Federation of State Licensure Examination (FLEX). License to practice in Massachusetts, Maryland, Virginia and District of Columbia. ADMINISTRATIVE DUTIES • Director, NICHD/Georgetown University Training Program in Pediatric Endocrinology (1988-2002) • Chairman, Medicine and Physiology Department, Foundation for the Advanced Education in the Sciences at the National Institutes of Health (1990-2002) • Chairman, Selection Committee and Acting General Director, Foundation for Biomedical Research (IIBEAA), Athens Academy of Sciences and Letters, Athens, Greece (2001-2002) • Director, Division of Maternal and Child Health, and Member, Board of Directors, Athens University Medical School, Athens, Greece (2004-2005, 2007-) • Director, Division of Endocrinology, Metabolism and Diabetes, Evgenidion Hospital, Athens University Medical School, Athens, Greece (2005- date) II. ACADEMIC HONORS AND AWARDS 1. 1969-1975 "Scholarship of Excellence" awarded by the State Scholarship Institution, Ministry of Education, Greek Government. 2. 1972-1975 Scholarship "A. Papadakis", Athens University, Athens, Greece. 3. 1975 M.D. Degree summa cum laude, Athens, University, Faculty of Medicine, Athens, Greece. 4. 1977 Doctorate Diploma, "Excellent." Athens University, Athens, Greece. 5. 1981-1983 Clinical Assistant Professor of Pediatrics 1983-1985 Clinical Associate Professor of Pediatrics 1985-Date Clinical Professor of Pediatrics, Georgetown University Medical School, Washington, D.C. 6. 1987 June The "Richard E. Weitzman Memorial Award," awarded by the U.S. Endocrine Society "for outstanding research achievements in the fields of endocrinology and metabolism". 7. 1990-Date Adjunct Professor of Physiology and Biophysics, Georgetown University Medical School, Washington, D.C. 8. 1990 Expert Testimony to 101st US Congress 9. 1991 May The "Galen Award", Hellenic American Society for the Health Sciences, Washington, D.C. 10. 1991 July Honorary Faculty, Keio University School of Medicine, Tokyo, Japan 11. 1992 June Superior Service Award, U.S. Public Health Service, "for pioneering studies on the regulation of hypothalamic-pituitary-adrenal axis function, leading to new insights into the pathophysiology of adrenal diseases and novel diagnostic strategies". 12. 1993 October Honorary Faculty, Parma University, Parma, Italy 13. 1997 June The 1997 Endocrine Society Clinical Investigator Award, “for major achievements in clinical investigation”. 14. 1997 July The 1997 Hans Selye Award, Hans Selye Foundation, Montreal, Canada, “for outstanding contributions to stress research.” 15. 1999 June First Prize, 1999 Pharmacia-Upjohn International Award for Excellence in Published Clinical Research awarded by the US Endocrine Society. 3

George P. Chrousos, M.D. 16. 1999 June Professor of Pediatrics, Athens University Medical School (elected) 17. 1999 October The 1999 Novera Herbert Spector Award, International Society for Neuroimmunomodulation, Lugano, Switzerland “for significant contributions in both leadership and research in neuroimmunomodulaton.” 18. 1999 October Certificate of Commendation, American Academy of Pediatrics “for important contributions made to the mission and goals of the Academy and to the children.” 19. 2000 Sept. The 2000 Henning Andersen Prize, European Society for Pediatric Endocrinology, Brussels, Belgium 20. 2000 Nov. Mastership Award, American College of Endocrinology, “for distinction as a role model and as a contributor to the Art and Science of Endocrinology.” 21. 2001 August Certificate of Recognition, Howard Hughes Medical Institute, Teachers and Students Internship Program, Bethesda MD 22. 2001 Nov ISI Highly Cited Researcher in Clinical Medicine, ISI, Philadelphia, Pa. www.ISIhighlycited.com 23. 2001 Nov. Fellow, Japan Health Sciences Foundation, Tokyo, Japan 24. 2002 April Clinical Endocrinology Trust Professor 2002, Sir Edward Sharpey-Schafer Medal, British Endocrine Societies, for “major contributions to Endocrinology and Metabolism” 25. 2003 March Doctor Honoris Causa, University of Liege, Liege, Belgium 26. 2004 July Lifetime Achievement Award, International Society for Psycho-Neuro-Endocrinology, Glasgow, UK for “outstanding scholarship and path-breaking contributions to Psychoneuroendocrinology”. 27. 2004 Dec Distinguished Physician Award, Hellenic Medical Society of New York 28. 2005 April Mastership Award, American College of Physicians, “for significant contributions to the Art and Science of Medicine” 29. 2006 May Doctor Honoris Causa, Universita Politechnica delle Marche, Ancona, Italy 30. 2006 June ISI Highly Cited Researcher in Biochemistry and Biology, ISI, Philadelphia, Pa. www.ISIhighlycited.com 31. 2006 Dec The 2006 Gentle Giant Award, Pituitary Network Association, Rancho Mirage, Ca. “for exceptional services above and beyond in the study of pituitary diseases” 32. 2007 April The 2007 Henning Andersen Prize, European Society for Pediatric Endocrinology, Helsinki, Finland 33. 2007 June Symposium on Cortisol Secretion Abnormalities Honoring Dr. George P. Chrousos Horm Metab Res. 2007 Jun; 39(6): 401-3. III. SELECTED NAMED LECTURES 1989 Beth Israel Seminar in Medicine, Harvard University Medical School, Boston, MA; 1989 Israel Macher Memorial Lecture, Albert Einstein College of Medicine, New York, NY; 1990 Christos Choremis Memorial Lecture, Hellenic Pediatric Society Annual Meeting, Thessaloniki, Greece; 1991 Ira Rosenthal Lecture in Pediatrics, University of Illinois, Chicago, IL; 1994 Beth Israel Seminar in Medicine, Harvard University Medical School, Boston, MA; 1994 Millie Schembechler Memorial Conference on Adrenal Cancer, University of Michigan, Ann Arbor, MI; 1995 Mark Dodge Memorial Lecture, University of Kansas and University of Missouri at Kansas City, MO; 1996 Robert Vine Memorial Lecture, Australasian Pediatric Endocrinology Group Annual Meeting, Adelaide, Australia; 1997 Clinical Investigator Lecture, Endocrine Society, Minneapolis, MN; 1997 Hans Selye Memorial Lecture, International Congress of Stress, Budapest, Hungary; 4

George P. Chrousos, M.D. 1997 The J. Lester Gabrilove Lecture, Mount Sinai Medical School, New York, NY, 1998 The Novum Lecture, Karolinska Institute, Huddinge, Sweden, 1998 The 1998 Dennis Ikkos Memorial Lecture, Hellenic Endocrine Society, Athens, Greece. 1999 The 1999 Novera Herbert Spector Lecture, Fourth International Congress of the International Society for Neuroimmunomodulation, Lugano, Switzerland. 1999 The 1999 Novartis Lecture, Canadian Society of Endocrinology and Metabolism, Ottawa, Canada 2000 The 2000 Nicholas Zervas Distinguished Lecture in Neuroendocrinology, Harvard University Medical School, Boston, Massachusetts. 2001 The 2001 George Merikas Memorial Lecture in Medicine, The University of Athens Medical School, Athens, Greece 2001 Commencement Address, The University of Patras Medical School, Patras, Greece 2002 The 2002 Visiting Professor Lecture, British Endocrine Societies, Harrogate, England 2002 The 2002 Keith Harrisson Memorial Lecture, The Endocrine Society of Australia, Adelaide, Australia 2003 The 2003 Dennis Ikkos Memorial Lecture, Hellenic Endocrine Society, Thessaloniki, Greece 2003. Distinguished Lecturer in Stress Biology, Children’s Hospital of Philadelphia, University of Pennsylvania 2006. The 2006 Dennis Ikkos Memorial Lecture, Hellenic Endocrine Society, Athens, Greece 2007. Calouste Gulbenkian Foundation Lecture on “Stress, Inflammation and Well-being”, Lisbon, Portugal 2007. Megaron plus lecture on “Genes, Brain, Stress, and Evolution”, Athens, Greece VI. MEMBERSHIPS IN PROFESSIONAL AND SCIENTIFIC ORGANIZATIONS American Society for Clinical Investigation (Elected 1989) Association of American Physicians (Inducted 1995) The Society for Pediatric Research (Elected 1985) The American Pediatric Society (Elected 1992) The Endocrine Society Lawson Wilkins Society for Pediatric Endocrinology The Society for Neuroscience American Federation for Clinical Research American Academy of Pediatrics (Fellow) American College of Physicians (Fellow, elected Master 2004) New York Academy of Sciences American Diabetes Association International Brain Research Organization International Society for Psychoneuroendocrinology Molecular Medicine Society (Fellow) European Society for Clinical Investigation (Elected 1995) American College of Endocrinology (Fellow; Master, Elected 2000) European Society for Pediatric Endocrinology (Corresponding Member, Elected 1997) Association of Program Directors in Endocrinology and Metabolism (1998-2002) Fellow, The World Innovation Foundation (2004-) V. MEMBERSHIP IN COMMITTEES - EDITORIAL BOARDS-SOCIETY BOARDS Medical Record Committee (Chairman), Clinical Center, NIH (1990-1997) Pediatric Care Committee, Clinical Center, NIH Clinical Research Review Board, NICHD, NIH NIH Graduate Medical Education Committee 5

George P. Chrousos, M.D. Memorial Endowment Committee, Mortimer B. Lipsett Memorial Fund, The Endocrine Society, Bethesda, Maryland (1984) Education Committee, The Endocrine Society, Bethesda, MD (1990-1993) Editorial Board, Neuro-Endocrin-Immunology (1987-1990) Editorial Board, Journal of Clinical Endocrinology and Metabolism (1992-1995) Editorial Board, NeuroImmunoModulation (1993-2002) Fogarty International Scholars Advisory Panel (1994-present) Editorial Board, Hellenic Medical Journal (1995-present) Consultant, Task Force on SES and Health (1995) and Mind-Body Network (1997, 2001), John and Catherine McArthur Foundation Editorial Board, Endocrinology and Metabolism (1995-1998) Scientific Advisory Board, Institute for Hormone and Fertility Research, University of Hamburg, Germany (1995-present) Editorial Board, Stress (1995-present) Board of Directors, Second World Congress on Stress, Melbourne, Australia 1998 Editorial Review Panel, "Panic, Anxiety, and Stress Disorders" (C.E. Koop, Chairman), Time Life Medical (1995-1997) Editorial Board, Molecular Psychiatry (1995-present) International Advisory Board, Arquivos Brasileiros de Endocrinologia e Metabologia (1996-present) Editorial Board, Metabolism, Clinical and Experimental (1996-present) Editorial Board, Endocrinology (1997- 2000) Medical Advisory Board, Cushing's Support and Research Foundation, Inc. (1996-Present) Public Health/Governmental Affairs Committee (Co-Chair), Pituitary Tumor Network Association (1995- Present) Scientific Advisory Board (Co-Chair), National Adrenal Diseases Foundation, Inc. (1996-Present) Practice Guidelines Subcommittee, American Academy of Asthma, Allergy and Immunology (1997-Present) Editorial Board, Endocrine (1997- ) Committee on Classification of Corticotropin-Releasing Factor Receptors, International Union of Pharmacology (NC-IUPHAR) (1996-1998 ) Basic and Clinical Endocrinology Interest Group at the National Institutes of Health, Co-Chair (1997- ) Advisory Council, Klinefelter Syndrome Association of Canada (1998 - ) Editorial Board, Experimental and Clinical Rheumatology (1998 - ) Editorial Board, Trends in Endocrinology and Metabolism (1998 - ) Editorial Board, Iatriki (1998 - 2000) Editorial Board, Journal of Clinical Endocrinology and Metabolism (1999 - 2002) Board of Directors, International Society for the Investigation of Stress (1999- ) Editorial Board, Encyclopedia of Endocrine Disorders, Academic Press (1999- ) Editorial Board, Endocrine Practice (1999- ) Expert Consultant, Workgroup on Stress and Pre-Term Delivery, Centers for Disease Control, Atlanta, GA. (1999- ) Founding Member and Member of the Board, Association for Patient-Oriented Research (1999- 2002) National Aeronautics and Space Administration (NASA) Life Sciences Standing Panel, Chair (12/1/1999- 11/30/2002) Editorial Board, Current Drug Targets-Immune, Endocrine Metabolic Disorders (CDT-IEMD), (2000- ) Editor-in-Chief, On-line Textbook, Pediatric Endocrinology, www.eMedicine.com Associate Editor, On-line Textbook, Endocrinology and Metabolism, www.endotext.org Special Advisory Committee (Member), Endocrine Journal, The Japan Endocrine Society (2000- ) Editorial Board, Reviews in Endocrine and Metabolic Disorders (2000- ) Board of Directors, Pituitary Network Association (2000- ) Associate Editor, Hormones, Greek Endocrine Society (2001- ) Vice President, Hellenic Society of Pediatric and Adolescent Endocrinology (2001-2006) President, International Society for NeuroImmunoModulation (2002-2005) Editorial Board, Journal of Endocrinological Investigation (2002- ) International Board, The National Institute of Stress Evaluation and Management (2002- ) 6

George P. Chrousos, M.D. Editor-in-Chief, Neuroimmunomodulation (2002- 2006) Endocrinology Consultant, Stedman’s Medical Dictionary (2002- ) Advisory Committee on Science and Technology, Greek Orthodox Archidiocese of America (2002- ) Consensus Statement, Congenital Adrenal Hyperplasia, Lawson Wilkins Pediatric Endocrine Society and European Society for Pediatric Endocrinology, Boston (2002) Board of Counselors, The Suffering Child (2003-) (www.thesufferingchild.net) Consensus Statement on Cushing Syndrome (2002), International Symposium on Cushing Syndrome, Ancona, Italy Consensus Statement on Adrenocortical Carcinoma (2003), International Schembechler Conference on Adrenocortical Carcinoma, University of Michigan, Ann Arbor, Michigan Scientific American, Greek Edition, Scientific Advisory Board (2003- ) Scientific Advisory Board, Research Center of Intensive and Thoracic Medicine, Athens, Greece (2003-) Metabolism Network, Society for Women’s Health, Washington, DC (2003-) Associate Editor, The Encyclopedia of Stress (2004-) Associate Editor, Adolescent Gynecology, Reproduction and Menopause (2004- ) Editorial Board, American Journal of Medicine (2005- ) Editorial Board, Gender Medicine (2005-) Adrenal Insufficiency Task Force, American College of Critical Care Medicine (2005- ) Member of the Council, European Society for Clinical Investigation (2005- ) Member, MEDINE, Medical Education in Europe (2005-) President, Hellenic Society of Pediatric and Adolescent Endocrinology (2006-) President, Hellenic College of Pediatrics (2006-) President Elect, European Society for Clinical Investigation (2008-) Editorial Board, The Journal of Neuroendocrinology (2007-) 7

George P. Chrousos, M.D. George P. Chrousos, MD PUBLICATIONS A. ORIGINAL ARTICLES p. 9-52 B. CHAPTERS, REVIEWS, EDITORIALS p. 52-82 C. BOOKS p. 82-83 8

George P. Chrousos, M.D. A. ORIGINAL ARTICLES 1. Musliner T., Chrousos G.P., Amos H. (1977) Transport Enhancement and Reversal: Glucose and 3-0- Methylglucose. J. Cell. Physiology 91: 155-168. 2. Chrousos G.P., Barnes K.M., Sauer M.A., Loriaux D.L., Cutler G.B. Jr. (1980) 1,9(11)-11- Deoxycortisol: An Improved Antiglucocorticoid. Endocrinology 107: 472-477. 3. Chrousos G.P., Loriaux D.L., Sherins R., Cutler G.B. Jr. (1981) Unilateral Testicular Enlargement Resulting from Inapparent 21-Hydroxylase Deficiency. J. Urol. 126: 127-128. 4. Chrousos G.P., Poplack D., Kostolich M., Wiede C., Oliff A., Brown T., Bercu B. (1981) Hypothalamic- Adenohypophyseal Function in the Rhesus Monkey: A Primate Model. J. Med. Primatol. 10(2): 61-71. 125 5. Chrousos G.P., Wachsclicht-Rodbard H., Adams A., Roth J., Cornblath M. (1981) Increased I- Insulin Specific Binding in Hypoglycemic Infants and Children. Ped. Res. 15: 1345-1347. 6. Wishnick M.M., Valenti Q., Doyle E.F., Balian A., Genieser N., Chrousos G.P. (1982) Churg-Strauss Syndrome: Development of Cardiomyopathy during Corticosteroid Treatment. Am. J. Dis. Child. 136: 339-344. 7. Chrousos G.P., Peck G., Gross E., Cutler G.B. Jr., Loriaux D.L. (1982) Adrenal Function in Women with Idiopathic Acne, J. Invest. Dermatol. 78 (6): 468-471. 8. Chrousos G.P., Loriaux D.L., Mann D., Cutler G.B. Jr. (1982) Late-onset 21-hydroxylase deficiency is an allelic variant of congenital adrenal hyperplasia characterized by attenuated clinical expression and different HLA haplotypes associates. Horm. Res. 16: 193-200. 9. Chrousos G.P., Brown T., Bercu B. (1982) Pharmacologic Effects of Melatonin on Hypothalamic- Adenohypophyseal Function in the Nonhuman Primate. Neuroendocrinology 34: 343-346. 10. Chrousos G.P., Renquist D., Brandon D., Barnard D., Fowler D., Loriaux D.L., Lipsett M.B. (1982) The Squirrel Monkey: Receptor-mediated End-organ Resistance to Progesterone? J. Clin. Endocrinol. Metab. 55: 364-368. 11. Chrousos G.P., Renquist D., Brandon D., Eil C., Pugeat M., Vigersky R., Cutler G.B., Loriaux D.L., Lipsett M.B. (1982) Glucocorticoid Resistance and Primate Evolution: Receptor-mediated Mechanisms. Proc. Natl. Acad. Sci. 179: 2036-2040. 12. Chrousos G.P., Loriaux D.L., Mann D.L., Cutler G.B. Jr. (1982) Late-onset 21-Hydroxylase Deficiency Mimicking Polycystic Ovarian Disease: An Allelic Variant of Congenital Virilizing Adrenal Hyperplasia with a Milder Enzymatic Defect. Ann. In. Med. 96: 143-148. 13. Chrousos G.P., Poplack D., Brown T., O'Neil D., Schwade J., Bercu B. (1982) Effects of Cranial Radiation on Hypothalamic-Anterior Pituitary Function: Abnormal Growth Hormone Secretory Dynamics. J. Clin. Endocrinol. Metab. 54: 1135-1139. 14. Chrousos G.P., Vingerhoeds A., Brandon D., Pugeat M., Eil C., Loriaux D.L., Lipsett M.B. (1982) Primary Cortisol Resistance in Man: A Glucocorticoid Receptor-mediated Disease. J. Clin. Invest. 69: 1261-1269. 15. Cassorla F., Albertson B., Chrousos G.P., Booth J., Renquist D., Lipsett M.B., Loriaux D.L. (1982) The Mechanism of Hypercortisolemia in the Squirrel Monkey. Endocrinology 111: 448-451. 16. Schulte H.M., Chrousos G.P., Oldfield R., Gold P., Cutler G.B. Jr., Loriaux D.L. (1982) The effects of 9

George P. Chrousos, M.D. Corticotropin Releasing Factor on the Anterior Pituitary Function of Stalk-Sectioned Cynomolgus Macaques. Dose Response of Cortisol Secretion. J. Clin. Endocrinol. Metab. 55: 810-812. 17. Schulte H.M., Chrousos G.P., Gold P., Philips J., Cutler G.B. Jr., Loriaux D.L. (1982) Metabolic Clearance Rate and Plasma Half-life of Radioiodinated Corticotropin Releasing Factor in a Nonhuman Primate. J. Clin. Endocrinol. Metab. 55: 1023-1025. 18. Chrousos G.P., Sauer M.A., Cutler G.B. Jr., Loriaux D.L. (1982) 1-11-Oxa-11-deoxycortisol: A New Antiglucocorticoid with Activity in vivo. Steroids 40: 425-431. 19. Healy D.L., Hodgen G.D., Schulte H.M., Chrousos G.P., Loriaux D.L., Nicholas R.H., Goldstein H.L. (1983) The Thymus-adrenal Connection: Thymosin Has Corticotropin Releasing Activity in Primates. Science 222: 1353-1355. 20. Chrousos G.P., Vingerhoeds A.C.M., Loriaux D.L., Lipsett M.B. (1983) Primary Cortisol Resistance: A Family Study. J. Clin. Endocrinol. Metab. 56: 1243-1245. 21. Healy D.L., Chrousos G.P., Schulte H.M., Williams R.F., Baulieu E.E., Gold P.W., Hodgen G.D. (1983) Pituitary and Adrenal Responses to the Anti-progesterone and Antiglucocorticoid Steroid RU 486 in Primates. J. Clin. Endocrinol. Metab. 57: 863-865. 22. Jacobowitz D.M., Schulte H.M., Chrousos G.P., Loriaux D.L. (1983) Localization of GRF-like Immunoreactive Neurons in the Rat Brain. Peptides 4: 521-524. 23. Pugeat M., Rocle B., Chrousos G.P., Dunn J., Lipsett M.B., Nisula B.C. (1984) Plasma Testosterone Transport and Primate Evolution. J. Steroid Biochem. 20: 473-478. 24. Schulte H.M., Chrousos G.P., Gold P.W., Oldfield E.H., Cutler G.B. Jr., Loriaux D.L. (1984) Corticotropin Releasing Factor: Pharmacokinetics in Man. J. Clin. Endocrinol. Metab. 58: 192-196. 25. Doppman J.L., Oldfield E.H., Krudy A.G., Chrousos G.P., Schulte H.M., Loriaux D.L., Schaaf M. (1984) Anatomic and Technical Considerations of the Inferior Petrosal Sinus Sampling for Cushing's Disease. Radiology. 150: 999-103. 26. Almeida O.F.X., Schulte H.M., Rittmaster R.S., Chrousos G.P., Loriaux D.L., Merriam G.R. (1984) Potency and Specificity of a Growth Releasing Factor in a Primate and in Vitro. J. Clin. Endocrinol. Metab. 58: 309-312. 27. Chrousos G.P., Brandon D., Tomita M., Renquist D., Hogan W., Loriaux D.L., Lipsett M.B. (1984) Estrogen and Progesterone Receptors in a Progesterone "Resistant" New World Primate. J. Clin. Endocrinol. Metab. 58: 516-520. 28. Chrousos G.P., Schulte H.M., Oldfield E.H., Gold P.W., Cutler G.B. Jr., Loriaux D.L. (1984) The Corticotropin Releasing Factor Stimulation Test: An Aid in the Differential Diagnosis of Cushing's Syndrome. N. Engl. J. Med. 310: 622-627. 29. Schulte H.M., Chrousos G.P., Avgerinos P., Gold P.W., Oldfield E.H., Cutler G.B. Jr., Loriaux D.L. (1984) The Corticotropin Releasing Factor Stimulation Test: a Possible Aid in the Evaluation of Adrenal Insufficiency. J. Clin. Endocrinol. Metab. 58: 1064-1067. 30. Chrousos G.P., Loriaux D.L., Brandon D., Hogan W., Renquist D., Johnson E., Lipsett M.B. (1984) Adaptation of the Mineralocorticoid Target Tissues to the High Circulation Cortisol and Progesterone Plasma Levels in the Squirrel Monkey. Endocrinology 115: 25-32. 10

George P. Chrousos, M.D. 31. Pugeat M., Chrousos G.P., Nisula B., Loriaux D.L., Brandon D.D., Lipsett M.B. (1984) Plasma Cortisol Transport and Primate Evolution. Endocrinology 115: 357-361. 32. Rock J., Oldfield E.H., Schulte H.M., Gold P.W., Kornblith P.L., Loriaux D.L., Chrousos G.P., (1984) Corticotropin Releasing Factor Administered into the Ventricular CSF Stimulates the Pituitary-adrenal Axis. Brain Res. 323: 376-368. 33. Crawley J.N., Ninan P.T., Pickar D., Chrousos G.P., Linnoila M., Scolnick, Paul S.M. (1984) Neuropharmacological Antagonism of the beta-Carboline-induced "Anxiety" Response in Rhesus Monkeys. J. Neuroscience 5: 477-485. 34. Winterer J., Chrousos G.P., Cassorla F., Loriaux D.L. (1984) Acquired Refractoriness to Growth Hormone in a Patient with Isolated Growth Hormone Deficiency: Growth Hormone and Plasma Somatomedin C Response to High Dose Growth Hormone Therapy. J. Pediatrics, 104: 908-911. 35. Schuermeyer T.H., Avgerinos P.C., Gold P.W., Cutler G.B. Jr., Loriaux D.L., Chrousos G.P. (1984) Human Corticotropin Releasing Factor in Man. Pharmacokinetic Properties and Dose-response of Plasma ACTH and Cortisol Secretion. J. Clin. Endocrinol. Metab. 59: 1103-1108. 36. Udelsman R., Bacher J., Galluci W., Gold P.W., Morin M.L., Renquist D., Loriaux D.L., Chrousos G.P. (1984) Hemodynamic and Endocrine Parameters in the Anesthetized Cynomolgus Monkey: A Primate Model. J. Med. Primatol. 13: 327-337. 37. Chrousos Antonakou G., Levine Ross J., Chrousos G.P., Chu F.C., Kenigsberg D., Cutler G.B. Jr., Loriaux D.L. (1984) Ocular Findings in Turner Syndrome. A Prospective Study. Ophthalmology 91: 926-928. 38. Tomita M., Chrousos G.P., Brandon D.D., Ben-Or S., Foster C., DeVougn L., Taylor S.J., Loriaux D.L., Lipsett M.B. (1985) Glucocorticoid Receptors in Epstein-Barr Virus-transformed Human Lymphocytes. Hormone Metabol. Res. 17: 674-678. 39. Oldfield E.H., Chrousos G.P., Schulte H.M., Rock J.P., Poplack D.G., Gold P.W., Culter G.B. Jr., Kornblith P.L., Loriaux D.L. (1985) Active Clearance of Corticotropin-Releasing Factor from the Cerebrospinal Fluid. Neuroendocrinology 40: 84-87. 40. Evans M.I., Chrousos G.P., Mann D.L., Larsen J.W., McCluskey J., Green I., Loriaux D.L., Overpeck J., Fletcher J., Schulman J. (1985) Attempted Prevention of Abnormal Genital Masculinization in Suspected Congenital Adrenal Hyperplasia by Adrenocortical Suppression in Utero. JAMA 253:1015- 1020. 41. Schulte H.M., Chrousos G.P., Oldfield E.H., Gold P.W., Cutler G.B. Jr., Loriaux D.L. (1985) Corticotropin Releasing Factor Administration in Normal Men: Pituitary and Adrenal Responses in the Morning and Evening. Horm. Res. 21: 69-74. 42. Winterer J., Chrousos G.P., Loriaux D.L., Cutler G.B. Jr. (1985) The Adrenal Suppressive Effect of Hydrocortisone in Congenital Adrenal Hyperplasia is not Affected by Varying the Dose Schedule. J. Pediatrics 106: 137-142. 43. Schuermeyer T.H., Gold P.W., Galluci W.T., Tomai T.P., Cutler G.B. Jr., Loriaux D.L., Chrousos G.P. (1985) Effects and Pharmacokinetic Properties of the rat/human Corticotropin Releasing Factor (r/h CRF) in Rhesus Monkeys. Endocrinology 117: 300-306. 44. Schutt-Aine J., Young M.A., Pescovitz O.H., Chrousos G.P., Marx S.J. (1985) Hypoparathyroidism: a Possible Cause of Rickets. J. Pediatrics. 106: 255-259. 45. Healy D.L., Chrousos G.P., Schulte H.M., Gold P.W., Hodgen G.D. (1985) Increased ACTH, Cortisol and 11

George P. Chrousos, M.D. Arginine Vasopressin (AVP) Secretion Following the Antiglucocorticoid RU 486: Dose-response Relationships. J. Clin. Endocrinol. Metab. 60: 1-4. 46. Oldfield E.H., Chrousos G.P., Schulte H.M., Loriaux D.L., Schaaf M., Doppman J. (1985) Preoperative Lateralization of ACTH Secreting Pituitary Microadenomas by Bilateral and Simultaneous Inferior Petrosal Sinus Sampling: N. Engl. J. Med. 312: 100-103. 47. Rittmaster R.S., Cutler G.B. Jr., Sobel D.O., Koppelman M.C.S., Loriaux D.L., Chrousos G.P. (1985) Morphine Inhibits the Pituitary-adrenal Response to Ovine Corticotropin Releasing Factor in Normal Subjects. J.Clin. Endocrinol Metab 60: 891-895. 48. Schuermeyer T.H., Tsokos G.C., Avgerinos P.C., Loriaux D.L., Balow J.E., Chrousos G.P. (1985) Pituitary-adrenal Responsiveness to Corticotropin-releasing Hormone in Patients Receiving Chronic, Alternate-day Glucocorticoid Therapy. J. Clin. Endocrinol. Metab. 61: 22-27. 49. Schulte H.M., Chrousos G.P., Gold P.W., Booth J.D., Oldfield E.H., Culter G.B. Jr., Loriaux D.L. (1985) Continuous Administration of Corticotropin Releasing Hormone in Normal Volunteers: Physiological and Pathophysiological Implications. J. Clin. Invest. 75: 1781-1785. 50. Susman E., Nottelman F., Inoff G., Dorn L., Loriaux D.L. Cutler G.B. Jr., Chrousos G.P. (1985) The Relation of Hormonal Level and Physical Development and Social-emotional Behavior in Young Adolescents. J. Youth and Adolescence. 14: 245-264. 51. Rose S., Schulte H.M., Rauch A., White B., Hill S., Chandra R., Randolf J., Loriaux D.L., Chrousos G.P. (1985) Testicular Dysgenesis and Mixed Gonadal Dysgenesis: Biochemical Characterization and Management of a Typical Case. J. Ped. Endocrinol. 1: 123-128. 52. Berrettini H.W., Nurnberger J., Gold P.W., Chretien M., Chrousos G.P., Chan J.S.D., Goldin L.R., Gerson E. (1985) Neuropeptides in the Human Cerebrospinal Fluid. Life Sciences 37: 1265-1270. 53. Udelsman R., Harwood J., Millan M., Chrousos G.P., Catt K.J., Aguilera G. (1985) Functional Receptors for Corticotropin Releasing Factor in the Primate Peripheral Sympathetic System. Nature 319: 147-150. 54. Berrettini W.H., Nurnberger J.I., Chan J.S., Chrousos G.P., Gaspar L., Gold P.W., Seidah N.G., Simmons- Alling S., Goldin L.R., Chretien M., Gershon E.S. (1985) Proopiomelanocortin-related Peptides in Cerebrospinal Fluid: A Study of Manic Depressive Disorder. Psychiatry Res. 16: 287-302. 55. Nieman L.K., Chrousos G.P., Kellner C., Spitz I., Nisula B., Cutler G.B. Jr., Merriam G.R., Bardin C.W., Loriaux D.L. (1985) Successful Treatment of Cushing's Syndrome with the Glucocorticoid Antagonist RU 486. J. Clin. Endocrinol. Metab. 61: 536-540. 56. Gold P.W., Loriaux D.L., Roy A., Kling M.A., Calabrese J.R., Kellner C.H., Nieman L.K., Post R.M., Pickar D., Gallucci W., Avgerinos P., Paul S., Oldfield E.H., Cutler G.B. Jr., Chrousos G.P. (1986) Responses to Corticotropin Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease: Pathophysiologic and Diagnostic Implications. N. Engl. J. Med. 314: 1329-35. 57. Rose S.R., Chrousos G.P., Cornblath M., Sidbury J. (1986) Oral Starch in the Management of Post- operative Nesidioblastosis. J. Pediatrics 108: 97-100. 58. Tomita M., Brandon D., Chrousos G.P., Vingerhoeds A.C.M., Foster C.M., Loriaux D.L., Lipsett M.B. (1986) Characterization of Glucocorticoid Receptors from Epstein-Barr Virus-transformed Lymphocytes from Glucocorticoid Resistant Patients and a New World Primate. J. Clin. Endocrinol. Metab. 62: 1145- 1154. 12

George P. Chrousos, M.D. 59. Weiss S.R.B., Post R.M., Gold P.W., Chrousos G.P., Sullivan T.L., Walker D., Pert A. (1986) CRF- induced Seizures and Behavior: Interaction with Amygdala Kindling. Brain Res. 372: 345-351. 60. Levine Ross J., Schulte H.M., Gallucci W.T., Cutler G.B. Jr., Loriaux D.L., Chrousos G.P. (1986) Ovine Corticotropin Releasing Hormone Stimulation Test in Normal Children. J. Clin. Endocrinol. Metab. 62: 390-392. 61. Schiebinger R., Chrousos G.P., Cutler G.B., Loriaux D.L. (1986) The Effect of Serum Prolactin on Plasma Adrenal Androgens and the Production and Metabolic Clearance Rate of Dehydroepiandrosterone Sulfate in Normal and Hyperprolactinemic Subjects. J. Clin. Endocrinol. Metab. 62: 202-209. 62. Gold P.W., Gwirtzman H., Avgerinos P., Nieman L.K., Gallucci W.T., Kaye W., Jimerson D., Ebert M., Rittmaster R., Loriaux D.L., Chrousos G.P. (1986) Abnormal Hypothalamic-pituitary-Adrenal Function in Anorexia Nervosa: Pathophysiologic Mechanisms in Underweight and Weight-corrected Patients. N. Engl. J. Med. 314: 1335-42. 63. Avgerinos P.C., Schuermeyer T., Gold P.W., Loriaux D.L., Cutler G.B. Jr., Chrousos G.P. (1986) Pulsatile Administration of Human Corticotropin Releasing Hormone in Patients with Secondary Adrenal Insufficiency: Restoration of the Normal Cortisol Secretory Pattern. J. Clin. Endocrinol. Metab. 62: 816- 821. 64. Rosner W., Pugeat M., Chrousos G.P., Khan M.S. (1986) Steroid Binding Proteins in Primate Plasma. Endocrinology. 118: 513-517. 65. Pavlov E.P., Harman M.S., Chrousos G.P., Loriaux D.L., Blackman M.R. (1986) Responses of Plasma Adrenocorticotropin (ACTH), Cortisol, and Dehydroepiandrosterone to Ovine Corticotropin Releasing Hormone in Healthy Aging Men. J. Clin. Endocrinol. Metab. 62: 767-772. 66. Oldfield E.H., Schulte H.M., Chrousos G.P., Gold P.W., Benker G., Peterson R.E., Cutler G.B. Jr., Loriaux D.L. (1986) Corticotropin Releasing Factor Stimulates ACTH Secretion in Nelson's Syndrome. J. Clin. Endocrinol. Metab. 62: 1020-1026. 67. Udelsman R., Gallucci W.T., Ramp J., Goldstein D.S., Lipford R., Norton J.A., Loriaux D.L., Chrousos G.P. (1986) Adaptation during Surgical Stress: A Reevaluation of the Role of Glucocorticoids. J. Clin. Invest. 77: 1377-1381. 68. Roy-Byrne P.P., Uhde T.W., Post R.M., Gallucci W., Chrousos G.P., Gold P.W. (1986) The CRH Stimulation Test in Patients with Panic Disorder. Am. J. Psychiatry, 143: 396-399. 69. Roy A., Gold P.W., Pickar D., Wolkowitz O.M., Chrousos G.P., Paul S.M. (1986) Pre- and Post- dexamethasone Plasma ACTH Levels in Depressed Patients and Normal Controls. J. Affective Dis. 10: 95- 99. 70. Udelsman R., Bacher J., Gallucci P.W., Gold P.W., Renquist D., Loriaux D.L., Chrousos G.P. (1986) Hemodynamic Effects of Human Corticotropin-releasing Factor (hCRF) in a Nonhuman Primate. Peptides 7: 465-471. 71. Munabi A., Feuillan P., Staton R., Rodbard D., Chrousos G.P., Anderson R.E., Strober M.D., Loriaux D.L., Cutler G.B. Jr. (1986) Adrenal Steroid Responses to Continuous Intravenous ACTH Infusion Compared to Bolus Injection. J. Clin. Endocrinol. Metab. 63: 1036-1040. 72. Nieman L.K., Chrousos G.P., Oldfield E.H., Avgerinos P.C., Cutler G.B. Jr., Loriaux D.L. (1986) The Ovine CRH Stimulation Test and the Dexamethasone Suppression Test in the Differential Diagnosis of Cushing's Syndrome. Ann. Int. Med. 105: 862-867. 13

George P. Chrousos, M.D. 73. A., Pickar D., Doran A., Wolkowitz O., Gallucci W., Chrousos G.P., Gold P.W. (1986) Normal ACTH and cortisol Responses to Corticotropin Releasing Hormone in Schizophrenia. Am. J. Psychiatry 143: 1393-1397. 74. Saris S.C., Patronas N.J., Doppman J.L., Loriaux D.L., Cutler G.B. Jr., Nieman L.K., Chrousos G.P., Oldfield E. (1986) Pituitary CT Scanning in Cushing's Syndrome. Radiology 162: 775-777. 75. Doppman J.L., Oldfield E.H., Chrousos G.P., Nieman L.K., Udelsman R., Cutler G.B. Jr., Loriaux D.L. (1986) Rebound Thymic Hyperplasia Following Treatment of Cushing's Syndrome. Am. J. Radiology 147: 1145-1147. 76. Feuillan P., Poth M., Reilly W., Bright G., Loriaux D.L., Chrousos G.P. (1986) Ketokonazole Treatment of Type Autoimmune Polyglandular Syndrome: Effects on Pituitary-adrenal Axis. J. Pediatrics, 109: 363- 366. 77. Nottelman E.D., Susman E.J., Dorn L.D., Inoff G.E., Loriaux D.L., Cutler G.B., Chrousos G.P. (1987) Developmental Processes in Early Adolescence: Relations among Chronological Age, Pubertal Stage, Height, Weight, and Serum Levels of Gonadotropins, Sex Steroids and Adrenal Androgens. J. Adol. Health Care 8: 35-48. 78. Susman E., Inoff G., Nottelman E., Dorn L., Loriaux D.L., Chrousos G.P. (1987) Hormones, Emotional Disposition and Aggression Attributes in Early Adolescents. Child Development 58: 1114-1134. 79. Rittmaster R.S., Cutler G.B. Jr., Brandon D., Gold P.W., Loriaux D.L., Chrousos G.P. (1987) The Effects of Endogenous Vasopressin on ACTH and Cortisol Secretion in Man. J. Clin. Endocrinol. Metab. 64: 371- 376. 80. Laue L., Hoeg J.M., Barnes K., Loriaux D.L., Chrousos G.P. (1987) The Effect of Mevinolin on Steroidogenesis in Patients with Defects in the LDL Receptor Pathway. J. Clin. Endocrinol. Metab. 64: 531-535. 81. Kaye W.H., Gwirtsman H.E., George D.T., Ebert M., Jimerson D., Tomai T., Chrousos G.P., Gold P.W. (1987) Elevated Cerebro-spinal Fluid Levels of Immunoreactive Corticotropin Releasing Hormone in Anorexia Nervosa: Relation to State of Nutrition, Adrenal Function and Intensity of Depression. J. Clin. Endocrinol. Metab. 64: 203-208. 82. Nieman L.K., Choate T., Chrousos G.P., Healy D., Spitz I., Merriam G.R., Bardin C.W., Loriaux D.L. (1987) Progesterone Antagonist RU 486: A Potential New Contraceptive Agent. N. Engl. J. Med. 316: 187-191. 83. Nottelman E.D., Susman E.J., Dorn L.D., Inoff E.G., Loriaux D.L., Cutler G.B., Chrousos G.P. (1987) Developmental Processes in American Early Adolescents: Relations Between Adolescent Adjustment and Chronological Age, Pubertal Stage and Puberty-related Hormone Levels. J. Pediatrics 110: 473-480. 84. Udelsman R., Norton J., Jelenich S., Goldstein D., Linehan W.M., Loriaux D.L., Chrousos G.P. (1987) Responses of the Hypothalamic-pituitary-adrenal and Renin-angiotensin Axis and the sympathetic System during Controlled Surgical and Anesthesia Stress. J. Clin. Endocrinol. Metab. 64: 986-994. 85. Feuillan P., Stein C.A., LaRocca R., Lipford N., Raffeld M., Renquist D., Meyers C.E., Chrousos G.P. (1987) Effects of Suramin on the Function and Structure of the Adrenal Cortex in the Cynomolgus Monkey. J. Clin. Endocrinol. Metab. 65: 153-158. 86. Kawai S., Nieman L.K., Brandon D.D., Udelsman R., Loriaux D.L., Chrousos G.P. (1987) 14

George P. Chrousos, M.D. Pharmacokinetic Properties of the Antiglucocorticoid and Antiprogesterone Steroid of RU 486 in Man. J. Exp. Pharmacol. Ther. 241: 401-406. 87. Luger A., Deuster P., Kyle S.B., Gallucci W.T., Montgomery L.C., Gold P.W., Loriaux D.L., Chrousos G.P. (1987) Acute Hypothalamic-pituitary-adrenal Responses to the Stress of Treadmill Exercise: Physiologic Adaptations to Physical Training. N. Engl. J. Med. 316: 1309-1315. 88. Doppman J.L., Loughlin T., Miller D.L., Pass V.J., Chrousos G.P., Cutler G.B. Jr., Oldfield E.H., Loriaux D.L. (1987) Identification of ACTH Producing Intrathoracic Tumors by Measuring ACTH Levels on Aspirated Specimens. Radiology 163: 501-503. 89. Risin Counts D., Hirsch Pescovitz O., Barnes K.M., Chrousos G.P., Sherins R.J., Comite F., Loriaux D.L., Cutler G.B. (1987) Dissociation of Adrenarche and Gonadarche in Precocious Puberty and in Hypogonadotropic Hypogonadism J. Clin. Endocrinol. Metab. 64: 1174-1178. 90. Udelsman R., Goldstein D., Loriaux D.L., Chrousos G.P. (1987) Catecholamine-glucocorticoid Interactions during Surgical Stress. J. Sur. Res. 43: 539-545. 91. May C., Rapoport S.J., Cutler N.R., Chrousos G.P., Tomai T.P., Gold P.W. (1987) CSF Concentrations of Corticotropin Releasing Hormone and Corticotropin Are Reduced in Patients with Alzheimer's Disease. Neurology 37: 535-538. 92. Roy A., Pickar D., Linnoila M., Chrousos G.P., Gold P.W. (1987) Cerebrospinal Fluid Corticotropin Releasing Hormone in Depression: Relationship to Noradrenergic Function. Psychiatry Res. 20: 229-237. 93. Avgerinos P.C., Cutler G.B. Jr., Tsokos G.C., Gold P.W., Feuillan P., Gallucci W.T., Pillemer S.R., Loriaux D.L., Chrousos G.P. (1987) Dissociation between Cortisol and Adrenal Androgen Secretion in Patients Receiving Alternate Day Prednisone Therapy. J. Clin. Endocrinol. Metab. 65: 24-29. 94. Roy A., Pickar D., Paul S., Doran A., Chrousos G.P., Gold P.W (1987) CSF Corticotropin Releasing Hormone in Depressed Patients and Normal Control Subjects. Am. J. Psychiatry 114: 641-645. 95. Luger A., Calogero A., Kalogeras K., Gallucci W., Gold P.W., Loriaux D.L., Chrousos G.P. (1987) Interaction of Epidermal Growth Factor with the Hypothalamic-pituitary Adrenal Axis: Potential Physiologic Relevance. J. Clin. Endocrinol. Metab. 66: 334-337. 96. Laue L., Chrousos G.P., Loriaux D.L., Nieman L.K., Munson P., Schaison G. (1987) RU 486 Suppresses the Plasma ACTH Response to Ovine Corticotropin-releasing Hormone. J. Clin. Endocrinol. Metab. 66: 290-293. 97. Grino M., Chrousos G.P., Margioris A. (1987) The Corticotropin Releasing Factor Gene is Expressed in the Human Term Placenta. Biol. Bioph. Res. Com 148: 1208-1214. 98. Doppman J.L., Miller D.L., Dwyer A.J., Loughlin T., Nieman L., Cutler G.B., Chrousos G.P., Oldfield E., Loriaux D.L. (1987) Macronodular Adrenal Hyperplasia in Cushing's Disease. Radiology 166: 347-352. 99. Avgerinos P.C., Chrousos G.P., Nieman L.K., Oldfield E.H., Loriaux D.L., Cutler G.B. (1987) The Corticotropin Releasing Hormone Test in the Postoperative Evaluation of Patients with Cushing's Syndrome. J. Clin. Endocrinol. Metab. 65: 906-913. 100. Balis F.M., Lester C.M., Chrousos G.P., Heideman R.L., Poplack D.G. (1987) Differences in Cerebrospinal Fluid Penetration of Corticosteroids: Possible Relationship to Prevention of Meningeal Leukemia. J Clin Oncol 5: 202-207. 15

George P. Chrousos, M.D. 101. Berrettini W.H., Nurnberger J.I. Jr., Zerbe R.L., Gold P.W., Chrousos G.P., Tomai T. (1987) CSF Neuropeptides in Euthymic Bipolar Patients and Controls. Br. J. Psychiatry 150:208-212. 102. Roy A., Gallucci W., Linnoila M., Chrousos G.P., Gold P.W. (1988) The CRH Stimulation Test in Bereaved Subjects with and without Accompanying Depression. Psych. Res. 25:145-156. 103. Albertson B., Brandon D.D., Chrousos G.P., Loriaux D.L. (1988) Adrenal 11-Hydroxylase Activity in a Hypercortisolemic New World Primate: Adaptive Intra-adrenal Changes. Steroids 49: 497-505. 104. Inoff-Germain G., Snyder Arnold G., Nottelmann E.D., Susman E.J., Cutler G.B. Jr., Chrousos G.P. (1988) Relations between Hormone Levels and Observational Measures of Aggressive Behavior of Young Adolescents in Family Interactions. Dev. Psychol. 24: 129-139. 105. Laue L., Hoeg J., Barnes K., Levine Ross J., Loriaux D.L., Chrousos G.P. (1988) Abnormal Growth Hormone Secretory Dynamics in Children with Familial Hypercholesterolemia. Hormone Res. 938:1-6. 106. Calogero A.E., Bernardini R., Gallucci W.T., Saoutis C., Gold P.W., Chrousos G.P. (1988) Cholinergic Stimulation of Rat Hypothalamic Corticotropin Releasing Hormone in Vitro. Neuroendocrinology 47: 303- 308. 107. Giuffre K., Udelsman R., Listwak S., Chrousos G.P. (1988) Effects of Immune Neutralization of CRH, ACTH, and Endorphin in the Surgically Stressed Rat. Endocrinology 122: 306-310. 108. Feuillan P., Pang S., Avgerinos P., Schuermeyer T., Chrousos G.P. (1988) Adaptation of the Hypothalamic-pituitary-adrenal Axis in Patients with Partial (Late-onset) 21-Hydroxylase Deficiency. J. Clin. Endocrinol. Metab. 67: 154-160. 109. Margioris A., Grino M., Protos P., Gold P.W., Chrousos G.P. (1988) Corticotropin Releasing Hormone and Oxytocin Stimulate the Secretion of Immunoreactive alpha-MSH, beta-Endorphin and ACTH from the Human Placenta In Vitro. J. Clin. Endocrinol. Metab. 66: 922-926. 110. Laue L., Kawai S., Brandon D., Knazek R., Loriaux D.L., Chrousos G.P. (1988) Receptor-Mediated Effects of Glucocorticoids on Inflammation: Enhancement of the Inflammatory Response with a Glucocorticoid Antagonist. J. Steroid Biochem. 29: 591-598. 111. Luger A., Deuster P., Kyle S.B., Gallucci W.T., Montgomery L.C., Loriaux D.L., Chrousos G.P. (1988) Renin-angiotensin Responses during Treadmill Exercise. Hormone Res. 30: 5-9. 112. Laue, L., Gallucci, W., Loriaux, D.L., Udelsman, R., Chrousos G.P. (1988) The Antiglucocorticoid and Antiprogestin Steroid RU 486: Its Glucocorticoid Agonist Effect is Inadequate to Prevent Adrenal Insufficiency in Primates. J. Clin. Endocrinol Metab. 67: 602-606. 113. Calogero A.E., Gallucci W.T., Chrousos G.P., Gold P.W. (1988) Interaction between Gabaergic Neurotransmission and Rat Hypothalamic Corticotropin Releasing Hormone Secretion In Vitro. Brain Res. 463: 28-36. 114. Calogero A.E., Gallucci W.T., Chrousos G.P., Gold P.W. (1988) Effect of the Catecholamines Upon Rat Hypothalamic Corticotropin Releasing Hormone Secretion In Vitro: Clinical Implications. J. Clin. Invest. 82: 839-846. 115. Calogero A., Gallucci W.T., Gold P.W., Chrousos G.P. (1988) Multiple Regulatory Feedback Loops on Hypothalamic Corticotropin Releasing Hormone Secretion. J. Clin. Invest. 82: 767-774. 116. Doppman J.L., Frank J.A., Dwyer A.J., Oldfield E.H., Miller D.L., Nieman L.K., Chrousos G.P., Cutler 16

George P. Chrousos, M.D. G.B. Jr., Loriaux D.L. (1988) Gadolinium DPTA Enhanced MR Imaging of ACTH-Secreting Microadenomas of the Pituitary Gland. J. Comp. Assist. Tom. 12: 728-735. 117. Laue L., Peacock J., Gallucci W.T., Brandon D.D., Cutler G.B. Jr., Loriaux D.L., Chrousos G.P., Norton J.A. (1988) Glucocorticoid Receptor-mediated Effects on Rat Fibrosarcoma Growth. Cancer Res. 48: 2703-2706. 118. Deuster P., Chrousos G.P., Luger A., Kyle S.B., Gallucci W.T., Montgomery L.C., Loriaux D.L. (1989) Sympathetic System Responses to the Stress of Treadmill Exercise. Physiologic Adaptations to Physical Training. Metabolism 38: 141-148. 119. Calogero A.E., Bernardini R., Margioris A.N., Gallucci W.T., Munson P.J., Tamarkin L., Tomai T.P., Brody L., Gold P.W., Chrousos G.P. (1989) Serotonin Stimulates Rat Hypothalamic Corticotropin Releasing Hormone Secretion In Vitro. Peptides 10: 189-210. 120. Kawai S., Brandon D., Loriaux D.L., Chrousos G.P. (1989) Interaction of RU 486, A Glucocorticoid and Progesterone Antagonist, with Human Circulating Mononuclear Leukocytes. Am. J. Med. Sci. 296: 167- 171. 121. Friedman R.B., Oldfield E.H., Nieman L.K., Chrousos G.P., Doppman J.L., Cutler G.B. Jr., Loriaux D.L. (1989) Repeat Transsphenoidal Surgery in Cushing's Disease. J. Neurosurg. 71: 520-527. 122. Margioris A., Koukoulis G., Grino M., Chrousos G.P. (1989) In Vitro Perifused Rat Testis Fragments Secrete beta-Endorphin and Dynorphin: Effect of Opioids on Testosterone Secretion. Biol. Reprod. 40: 776-784. 123. Perry R.R., Nieman L.K., Cutler G.B. Jr., Chrousos G.P., Loriaux D.L., Doppman J.L., Travis W.D., Norton J.A. (1989) Primary Adrenal Causes of Cushing's Syndrome: Diagnosis and Surgical Management. Ann. Surg. 210: 59-68. 124. Sternberg E., Hill J.M., Chrousos G.P., Kamilaris T., Listwak S., Gold P.W., Wilder R.L. (1989) Inflammatory mediator-induced Hypothalamic-pituitary-adrenal Axis Activation is Defective in Streptococcal Cell Wall Arthritis - susceptible Lewis Rats. Proc. Natl. Acad. Sci. USA 86: 2374-2378. 125. Gomez M.T., Chrousos G.P. (1989) Periodic Cushing's Syndrome in a Short Boy: Usefulness of the Ovine CRH Test. J. Pediatr. 115: 270-273. 126. Linder B., Feuillan P., Chrousos G.P. (1989) Alternate-day Prednisone Therapy in Congenital Adrenal Hyperplasia: Adrenal Androgen Suppression and Normal Growth. J Clin. Endocrinol. Metab. 69:91-195. 127. Bagdy G., Calogero A., Chrousos G.P., Szemeredi K. (1989) Delayed Effects of Chronic Cortisol Treatment on Brain and Plasma Concentrations of Corticotropin (ACTH) and beta-Endorphin. Brain Res. 489: 216-222. 128. Sternberg E.M., Young W.S. Jr., Bernardini R., Calogero A., Chrousos G.P., Gold P.W., Wilder R.L. (1989) A Central Nervous Defect in the Stress Response is Associated with Susceptibility to Streptococcal Cell Wall Arthritis in Lewis Rats. Proc. Natl. Acad. Sci. 86: 4771-4775. 129. Bernardini R., Chiarenza A., Calogero A.E., Gold P.W., Chrousos G.P. (1989) Arachidonic Acid Metabolites Modulate Rat Hypothalamic Corticotropin Releasing Hormone Secretion in Vitro. Neuroendocrinology 50: 708-715 130. Bernardini R., Calogero A.E., Ehlich Y.H., Brucke T., Chrousos G.P., Gold P.W. (1989). The Alkyl- ether Phospholipid Platelet-activating Factor is a Stimulator of the Hypothalamic-pituitary-adrenal Axis in the 17

George P. Chrousos, M.D. Rat. Endocrinology 125: 1067-1073. 131. Calogero A., Gallucci W.T., Chrousos G.P., Gold P.W. (1989) Cocaine Stimulates Rat Hypothalamic Corticotropin Releasing Hormone Secretion in Vitro. Brain Res. 505: 7-11. 132. Doppman J.L., Pass H.I. Nieman L., Cutler G.B. Jr., Chrousos G.P., Loriaux D.L. (1989) Failure of Bronchial Lavage to Select Elevated Levels of ACTH in Patients with ACTH-Producing Bronchial Carcinoids. J. Clin. Endocrinol. Metab. 69: 1302-1304. 133. Travis W.D., Tsokos M., Doppman J.L., Nieman L., Chrousos G.P., Cutler G.B., Loriaux D.L., Norton J.A. (1989) Primary Pigmented Nodular Adrenocortical Disease: A Light and Electron Microscopic Study of Eight Cases. Am. J. Surg. Pathol. 13: 921-930. 134. Calogero A., Kamilaris T., Gomez M.T., Johnson E.O., Tartaglia E., Gold P.W., Chrousos G.P. (1989) The Muscarinic Cholinergic Agonist Arecoline Stimulates the Rat Hypothalamic-pituitary-adrenal Axis Through a Centrally-mediated Corticotropin-releasing Hormone Mechanism. Endocrinology 125: 2445- 2453. 135. Doppman J.L., Travis W.D., Nieman L.K., Miller D.L., Pass H.I., Chang R., Cutler G.B. Jr., Chrousos G.P., Norton J.A., Ziessman H.A., Oldfield E.H., Loriaux D.L.v(1989) Cushing's Syndrome Due to Primary Pigmented Nodular Adrenocortical Disease: Findings at CT and MR Imaging. Radiology 172(2):415-420. 136. Doppman J.L., Nieman L.K., Miller D.L., Pass H.I., Chung R., Cutler G., Schauf M., Chrousos G.P., Norton J.A., Zirrsman H.A., Oldfield E.H., Loriaux D.L. (1989) Ectopic Adrenocorticotropin Hormone Syndrome: Localization Studies in 28 Patients. Radiology 172: 115-124. 137. Nieman L.K., Cutler G.B. Jr., Oldfield E.O., Loriaux D.L., Chrousos G.P. (1989) The Ovine Corticotropin Releasing Hormone Stimulation Test is Superior to the Human Cortico- tropin Releasing Hormone Test for the Detection of Cushing's Disease. J. Clin. Endocrinol. Metab. 69: 165-169. 138. Marx S.J., Jones G., Weinstein R.J., Chrousos G.P., Renquist D. (1989) Vitamin D and Mineral Metalbolism in New World and Old World Primates: A Novel State with Hyperphosphatetic Osteomalacia in Aotus trivirgatus. J. Olin. Endocrinol. Metab. 69:1282-1290 139. Pass H.I., Doppman J.L., Nieman L., Stovroff M., Veto J., Norton J.A., Travis W., Chrousos G.P., Cutler G.B. Jr. (1990) Management of the Ectopic ACTH Syndrome Due to Thoracic Carcinoids. Ann Thorac- Surg 50: 52-57. 140. Calogero A., Kling M.A., Gallucci W.T., Bernardini R., Chrousos G.P. and P.W. Gold (1990) Procaine and Lidocaine Stimulate Corticotropin Releasing hormone Secretion by Explanted Rat Hypothalami through a Sodium Conductance Independent Mechanism. Horm. Metab. Res. 22: 1-4. 141. Dorn L., Susman E.J., Nottelmann E.D., Inoff-Germain G., Chrousos G.P. (1990) Perceptions of Puberty: Adolescent, Parent, and Health Care Personnel Ratings of Pubertal Stage. Develop. Psych. 26: 322-329. 142. Gazdar A.F., LaRocca R.V., Chen T.R., Triche T.J., Myers C.E., Chrousos G.P., Brennan M.R., Stein C.A., Oie H.K. (1990) Establishment and Characterization of a Human Adrenocortical Carcinoma Cell Line That Expresses Multiple Pathways of Steroid Biosynthesis. Cancer Res. 50: 5488-5496. 143. Rabin D., Johnson E., Brandon D., Liapi C., Chrousos G.P. (1990) Glucocorticoids Inhibit Estradiol- induced Uterine Growth: Possible Role of Estrogen Receptors. Biol. Reprod. 42: 74-80. 144. Calogero A.E., Kamilaris T.C., Bernardini R., Johnson E.O., Chrousos G.P., Gold P.W. (1990) Relevance 18

George P. Chrousos, M.D. of the "Peripheral" Benzodiazepine Receptor System to Hypothalamic pituitary-adrenal Function: Physiological and Clinical Implications. J. Pharmacol Exp. Therap. 253: 729-737. 145. Margioris A., Brockmann G., Bohler H., Grino M., Vamvakopoulos N., Chrousos G.P. (1990) Expression and Localization of Growth Hormone - Releasing Hormone mRNA in Rat Placenta: In Vitro Secretion and Regulation of Its Peptide Product. Endocrinology 126: 151-158. 146. Malozowski S., Muzzo S., Burrows R., Leiva L., Loriaux L., Chrousos G.P., Winterer J., Cassorla F. (1990) The Hypothalamic-pituitary-adrenal Axis in Infantile Malnutrition. Clin. Endocrinol. 32:461-465. 147. Calogero A.E., Bagdy G., Szemereti, Tartaglia M.E., Gold P.W., Chrousos G.P. (1990) Mechanisms of Serotonin Agonist-induced Activation of the Hypothalamic-pituitary-adrenal Axis in the Rat. Endocrinology 126: 1888-1894. 148. Margioris A.N., Brockmann G., Kalogeras K., Fjellestad-Paulsen A., Stratakis C.A., Vamvakopoulos N., Chrousos G.P. (1990) Effect of Hypertonic Saline Infusion on the Levels of Immunoreactive Dynorphin in Extracted Human Plasma. J. Clin. Endocrinol. Metab. 71: 298-304. 149. Bernardini R., Kamilaris T.C., Calogero A.E., Johnson E.O., Gold P.W., Chrousos G.P. (1990) Interactions Between Tumor Necrosis Factor-, Hypothalamic Corticotropin-Releasing Hormone and Adrenocorticotropin Secretion in the Rat. Endocrinology 126: 2876-81. 150. Calogero A., Kamilaris T., Johnson E.O., Tartaglia M., Chrousos G.P. (1990) Recovery of the Rat Hypothalamic-pituitary-adrenal Axis after Prolonged Treatment with Dexamethasone. Endocrinology 127: 1574-1579. 151. Vamvakopoulos N., Karl M., Mayol V., Margioris A., Chrousos G.P. (1990) Structural Analysis of the Regulatory Region of the Human Corticotropin Releasing Hormone Gene. FEBS Lett 267:1-5. 152. Kalogeras K.T., Calogero A.E., Kuribayashi T., Khan I., Gallucci W.T., Kling M.A., Chrousos G.P., Gold P.W. (1990) In vitro and In vivo Effects of the Triazolobenzodiazepine Alprazolam on Hypothalamic- pituitary-adrenal Function: Pharmacologic and Clinical Implications. J Clin Endocrinol Metab, 70: 1462- 1471. 153. Rabin D., Schmidt P., Campbell G., Gold P.W., Jensvold M., Rubinow D., Chrousos G.P. (1990) Hypothalamic-pituitary-adrenal Function in Patients with the Premenstrual Syndrome. J. Clin. Endocrinol. Metab. 71: 1158-1162. 154. Doherty J.M., Nieman L.K., Cutler G.B., Chrousos G.P., Norton J. (1990) Time to Recovery of the Hypothalamic Pituitary-Adrenal Axis Following Curative Resection of Adrenal Tumors in Patients with Cushing's Syndrome. Surgery 108:1085-90. 155. Hurley D., Accilli D., Stratakis C., Karl M., Vamvakopoulos N., Rorer E., Constantine K., Taylor S., Chrousos G.P. (1991) Mutation of the Glucocorticoid Receptor Gene in Familial Glucocortcoid Resistance. J Clin Invest 87:680-686. 156. Laue L., Lotze M.T., Chrousos G.P., Barnes K., Loriaux D.L., Fleisher T.A. (1990) Effects of the Glucocorticoid Antagonist RU 486 in Man: Toxicity, Immunological and Hormonal Aspects. J. Clin. Endocrinol. Metab. 71:1474-1480. 157. Gomez M.T., Malozowski S, Winterer J., Chrousos G.P. (1991) Urinary Free Cortisol Values in Normal Children and Adolescents. J. Pediatrics 118:256-258. 158. Bernardini R., Calogero A., Mauceri, Chrousos G.P. (1990) Rat Hypothalamic Corticotropin Releasing 19

George P. Chrousos, M.D. Hormone Secretion In Vitro is Stimulated by Interleukin-1 in an Eicosanoid-dependent Manner. Life Sciences 47:1601-7. 159. Bagdy G., Calogero A., Szemeredi K., Gomez M.T., Sved A.F., Murphy D.L., Chrousos G.P., Gold P.W. (1990) -Endorphin Responses to Different Serotonin Agonists: Involvement of Corticotropin Releasing Hormone, Vasopressin and Direct Pituitary Action. Brain Res. 537(1-2):227-32. 160. Bagdy G., Calogero A., Szemeredi K., Chrousos G.P., Gold P.W. (1990) effects of Cortisol Treatment on Brain and Adrenal Cortcotropin Releasing Hormone Content. Regulat. Peptides 31:83-92. 161. Doppman J.L., Nieman L.K., Travis W.D., Miller D.L., Cutler G.B., Chrousos G.P. Norton J.A. (1991) CT and MR Imaging of Massive Macronodular Adrenocortical Disease: A Rare Cause of Autonomous Primary Adrenal Hypercortisolism. J. Comp. Asst. Tom. 15:773-779. 162. Bagdy G., Chrousos G.P., Calogero A. (1991) Circadian Patterns of Plasma Corticotropin, - Endorphin, Corticosterone and Prolactin after Immunoneutralization of Corticotropin-releasing Hormone. Neuroendocrinology 53:573-578. 163. Vanderpool J., Rosenthal N., Chrousos G.P., Wehr T., Skewerer R., Kasper S., Gold P.W. (1991) Evidence for Hypothalamic CRH Deficiency in Patients with Seasonal Affective Disorder. J. Clin. Endocrinol. Metab. 72:1382-1387. 164. Doppman J., Pass H., Nieman L.K., Findling J., Dwyer A., Feuerstein I., Ling A., Travis W., Cutler G.B., Chrousos G.P., Loriaux D.L. (1991) Magnetic Resonance Imaging for Detection of ACTH- producing Bronchial Carcinoid Tumors, Am. J. Roentgen. 156:39-43. 165. Johnson E.O., Kamilaris T.C., Carter S., Gold P.W., Chrousos G.P.. (1991) Environmental Stress and Reproductive Success in the Common Marmoset (Callithrix jacchus jacchus) Am. J. Primatol 25:191- 201 (1991). 166. Kling M.A., Doran A., Rubinow D.R., Roy A., Post R.M., Chrousos G.P., Gold P.W. (1991) CSF Levels of CRH, ACTH, and SRIF in Cushing's Syndrome, Major Depression, and Normal Volunteers: Physiological and Pathophysiological Interrelationships. J. Clin. Endocrinol. Metab. 72:260-271. 167. Laue L., Peck G., Gallucci W.T., Loriaux D.L., Chrousos G.P. (1991) Adrenal Androgen Secretion in Postadolescent Cystic Acne: Increased Adrenocortical Function without Hypersensitivity to ACTH. J. Clin. Endocrinol. Metab. 73:380-384. 168. Calogero A.E., Liapi C., Chrousos G.P. (1991) Hypothalamic and Suprahypothalamic Effects of Prolonged treatment with the Glucocorticoid Type II Receptor Agonist Dexamethasone in the Rat. J. Endocrinol. Invest. 14:277-286. 169. Smoak B., Deuster P., Rabin D., Chrousos G.P. (1991) Corticotropin-Releasing Hormone is Not the Sole Factor Mediating Exercise-induced ACTH Release in Humans. J. Clin. Endocrinol. Metab. 72:302-306. 170. Sombolos K., Kapetanos G., Kalogeras K.T., Christodoulou A., Chrousos G.P., Symeonidis P. (1991) Effect on Atrial Natriuretic Peptide by Bracing in Scoliosis. Boston Brace Removal Studied in 10 cases. Acta Orthop Scand. 62:379-82. 171. Waltman C., Blackman M.R., Chrousos G.P., Riemann C., Harman S.M. (1991) Spontaneous and Glucocorticoid-inhibited Adrenocorticotropic Hormone and Cortisol Secretion Are Similar in Healthy Young and Old Men. J. Clin. Endocrinol. Metab. 73:495-502. 172. Perini G.I., Dervinsky O., Hauser P., Gallucci W.T., Theodore W., Chrousos G.P., Gold P.W., Kling M.A. 20

George P. Chrousos, M.D. (1992) Effects of Carbamazepine on Pituitary-adrenal Function in Healthy Volunteers. J. Clin. Endocrinol. Metab. 74:406-412. 173. Travis W.D., Linnoila R., Tsokos M., Hitchcock C., Cutler G., Nieman L., Chrousos G.P., Pass H., Doppman J. (1991) Neuroendocrine Tumors of the Lung with Proposed Criteria for Large Cell Neuroendocrine Carcinoma: An Ultrastructural, Immunochemical, and Flow Cytometric Study of 35 Cases. Amer. J. Surg. Path. 15:529-553. 174. Demitrack M., Dale J., Straus S., Laue L., Listwak S., Kruesi M., Chrousos G.P., Gold P.W. (1991) Evidence of Impaired Activation of the Hypothalamic-pituitary-adrenal Axis in Patients with Chronic Fatigue Syndrome. J. Clin. Endocrinol. Metab. 73:1224-1234. 175. Karalis C., Sano H., Redwine J., Listwak S., Wilder R., Chrousos G.P. (1991) Autocrine or Paracrine Inflammatory Actions of Corticotropin Releasing Hormone In Vivo. Science 254:421-423. 176. Friedman T.C., Thomas P.M., Fleisher T.A., Feuillan P., Parker R.I., Cassorla F., Chrousos G.P. (1991) Frequent Occurrence of Asplenism and Cholelithiasis in Patients with Autoimmune Polyglandular Disease Type I. Amer. J. Med. 91:625-630. 177. Oldfield E.H., Doppman J., Nieman L.K., Chrousos G.P., Miller D.L., Katz D.A., Cutler G.B., Loriaux D.L. (1991) Petrosal Sinus Sampling with and without Corticotropin Releasing Hormone in Patients with Cushing's Syndrome. N. Engl. J. Med. 325:897-905. 178. Susman E.J., Dorn L.D., Chrousos G.P. (1991) Negative Affect and Hormone Levels in Young Adolescents: Concurrent and Predictive Perspectives. J. Youth Adolesc. 20:167-190. 179. Calogero A., Sternberg E., Bagdy G., Smith G., Bernardini R., Aksentijevich S., Wilder R.L., Gold P.W., Chrousos G.P. (1992) Neurotransmitter-induced Hypothalamic-pituitary-adrenal Axis Responsiveness is Defective in Inflammatory Disease-Susceptible Lewis Rats: In vivo and In vitro Studies Suggesting Globally Defective Hypothalamic CRH Secretion. Neuroendocrinology. 55:600-608. 180. Calogero A.E., Norton J.A., Sheppard B.C., Listwak S.J., Cromack D.T., Wally R., Jensen R.T., Chrousos G.P. (1992) Pulsatile Activation of the Hypothalamic - pituitary - adrenal Axis during Major Surgery. Metabolism 41:839-845. 181. Aksentijevich S., Whitfield Jr H.J., Young III W.S., Wilder R.L., Chrousos G.P., Gold P.W., Sternberg E.M. (1992) Arthritis-susceptible Lewis Rats Fail to Emerge from the Stress Non-responsive period. Dev. Brain Res. 65:115-118. 182. Flack M.R., Oldfield E.H., Cutler G.B., Zweig M.H., Melley J.D., Chrousos G.P., Loriaux D.L., Nieman L.K. (1992) The Use of Urine Free Cortisol in the High Dose Dexamethasome Suppression Test for the Differential Diagnosis of Cushing's Syndrome. Ann. Int. Med. 116:211-217. 183. Kamilaris T., Johnson E., Calogero A.E., Kalogeras K., Bernardini R., Chrousos G.P., Gold P.W. (1992) Cholecystokinin-octapeptide Stimulates Hypothalamic-pituitary-adrenal Function in Rats: Role of Corticotropin-releasing Hormone. Endocrinology 130:1764-1784. 184. Calogero A.E., Kamilaris T.C., Johnson E.O., P.W., Chrousos G.P., (1992) "Peripheral" Benzodiazepine receptor Ligands Stimulate Prolactin Release in the Rat. J. Neuroendocrinology 2:745-750. 185. Luger A., Watschinger B., Deuster P., Svoboda T., Clodi M., Chrousos G.P. (1992) Plasma Growth Hormone and Prolactin Responses to Graded Levels of Acute Exercise and to a Lactate Infusion. Neuroendocrinology 56:112-117. 21

George P. Chrousos, M.D. 186. Marini J.C., Bordenick S., Heavner G., Rose S., Hintz R., Rosenfeld R., Chrousos G.P. (1993). The Growth Hormone and Somatomedin Axis In Short Children with Osteogenesis Imperfecta. J. Clin. Endocrinol. Metab. 76:251-256. 187. Vamvakopoulos N., Mayol V., Margioris N., Chrousos G.P. (1992) Lack of Dexamethasone Modulation of mRNAs involved in the Glucocorticoid Signal Transduction Pathway in Two Cell Systems. Steroids 57:1-6. 188. Cash J.M., Crofford L.J., Gallucci W.T., Sternberg E.M., Gold P.W., Chrousos G.P. and Wilder R.L. (1992) Pituitary-adrenal Axis Responsiveness to Ovine CRH in Patients with Rheumatoid Arthritis Treated with Low-dose Prednisone. J. Rheumatol. 19:1692-6. 189. Deuster P.A., Singh A., Hofmann A., Moses F.M., Chrousos G.P.. (1992) Hormonal Responses to Ingesting Water or a Carbohydrate Beverage During a 2h Run. Med. Sci. Sport Exerc. 24:72-79. 190. Burnet P., Meffor I.N., Smith C.C., Chrousos G.P., Gold P.W., Sternberg E.M. (1992) Hippocampal [3H]- 8-hydroxy-2,3-(diphenylalanine)-tetralin binding site densities, serotonin receptor (5-HT1A) messenger ribonucleic acid abundance and serotonin levels parallel the activity of the hypothalamopituitary-adrenal axis in rat. J. Neurochemistry 59:1062-1070. 191. Sternberg E.M., Glowa J., Smith M.A., Calogero A.E., Listwak S.J., Aksentijevich S., Chrousos G.P., Wilder R.L., and Gold P.W. (1992) Corticotropin Releasing Hormone Related Behavioral and Neuroendocrine Responses to Stress in Lewis and Fischer Rats. Brain Res. 570:54-60. 192. Roy M.S., Roy A., Gallucci W.T., Collier B., Young K., Kamilaris T.C., Chrousos G.P. (1993) The Ovine Corticotropin Releasing Hormone Test in Type I Diabetic Patients and Controls: Suggestion of Mild Chronic Hypercortisolism. Metabolism 42:696-700. 193. Patchev V., Kalogeras K., Zelazowski P., Wilder R.L., Chrousos G.P. (1992). Increased Plasma Concentrations and Hypothalamic Content and In Vitro Release of Arginine-Vasopressin in Inflammatory Disease-prone, Hypothalamic CRH-deficient Lewis Rats. Endocrinology 131:1453-1457. 194. Kling A., Rubinow D.R., Doran A.R., Roy A., Davis C.L., Calabrese J.R., Nieman L.K., Post R.M., Chrousos G.P., Gold P.W. (1993) Cerebrospinal Fluid Immunoreactive Somatostatin Concentrations in Patients with Cushing's Disease and Major Depression: Relationship to Indices of Corticotropin-Releasing Hormone and Cortisol Secretion. Neuroendocrinology 57:79-88. 195. Chikanza I.C., Petrou P., Chrousos G.P., Kingsley G., and Panayi G. (1992) Detective Hypothalamic Response to Immune/Inflammatory Stimuli in Patients with Rheumatoid Arthritis. Arthritis and Rheumatism 35:1281-1288. 196. Karl M., Lamberts S.W., Detera-Wadleigh S., Encio I.J., Stratakis C.A., Hurley D.M., Accili D., Chrousos G.P. (1993) Familial Glucocorticoid Resistance Caused by a Splice Site Deletion in the Human Glucocorticoid Receptor Gene. J. Clin. Endocrinol. Metab. 76:683-89. 197. Crofford L.J., Sano H., Karalis K., Webster E.L., Goldmuntz E.A., Chrousos G.P., Wilder R.L. (1992) Local Secretion of Corticotropin Releasing Hormone in the Joints of Lewis Rats with Inflammatory Arthritis. J. Clin. Invest. 90:2555-2564. 198. Doppman J.L., Pass H.I., Nieman L.K., Miller D.L., Chang R., Cutler G.B., Chrousos G.P., Jaffe G.S., Norton J.A. (1992) Corticotropin-secreting Carcinoid Tumors of the Thymus: Diagnostic Unreliability of Thymic Venous Sampling. Radiology 184:71-74. 199. Cizza G., Brady L., Calogero A., Bagdy G., Lynn A.B., Kling M.A., Blackman M.R., Chrousos G. P., Gold 22

George P. Chrousos, M.D. P.W. (1992) Central Hypothyroidism is Associated with Advanced Age in Male Fischer 344/N Rats: In Vivo and In Vitro Studies. Endocrinology 131:2672-2680. 200. Smith C.C., Hauser E., Renaud N.K., Leff A., Aksentijevich S., Chrousos G.P., Wilder R.L., Gold P.W., Sternberg E.M. (1992) Increased Hypothalamic 3H-Flunitrazepam Binding in Hypothalamic- Pituitary- Adrenal Axis Hyporesponsive Rats. Brain Res 569:295-299. 201. Zelitch Yanovski S., Yanovski J.A., Gwirtsman H.E., Bernat A., Gold P.W., and Chrousos, G.P. (1993) Normal Dexamethasone Suppression in Obese Binge and Non-binge Eaters with Rapid Weight Loss. J. Clin. Endocrinol. Metab. 76:675-79. 202. Yanovski J.A., Cutler G.B., Chrousos, G.P., Nieman L.K. (1993) Corticotropin-releasing Hormone stimulation following low-dose dexamethasone administration: A new test to distinguish Cushings syndrome from Pseudo-Cushings states. JAMA 269:2232-38. 203. Zelazowski P., Smith M.A., Gold P.W., Chrousos G.P., Wilder R.L., Sternberg E.M. (1992) In Vitro Regulation of Pituitary ACTH Secretion in Inflammatory Disease Susceptible Lewis and Inflammatory Disease Resistant Fischer Rats. Neuroendocrinology 56:474-482. 204. Bouzas E.A., Mastorakos G., Chrousos G.P., Kaiser-Kupfer M.I. (1993) Lisch Nodules in Cushing Disease. Archives Ophthalmol. 111:439-40. 205. Swain M.G., Patchev V., Vergalla T., Chrousos G.P., Jones E.A. (1993) Suppression of Hypothalamic- pituitary-adrenal Axis Responsiveness to Stess in a Rat Model of Acute Cholestasis. J. Clin. Invest. 91:1903-1908. 206. Cizza G., Kvetnansky R., Tartaglia M.E., Blackman M.R., Chrousos G.P., Gold P.W. (1993) Immobilization Stress Rapidly Decreases Hypothalamic Corticotropin Releasing Hormone Secretion in Vitro in the male 344/N Fischer Rat. Life Sciences 53:233-240. 207. Crofford L.J., Sano H., Karalis K., Friedman T.C., Epps H.R., Remmers E.F., Mathern P., Chrousos G.P., Wilder R.L. (1993) Corticotropin-releasing Hormone in Synovial Fluids and Tissues of Patients with Rheumatoid Arthritis and Osteoarthritis. J. Immunology 151:1-10. 208. Chikanza I.C., Petrou P., Chrousos G.P., Kingsley G., Panayi G.S. (1993) Excessive and Dysregulated Secretion of Prolactin in Rheumatoid Arthritis: Immunopathogenetic and Therapeutic Implications. Br. J. Rheumatol. 32:445-448. 209. Gomez M.T., Magiakou M.A., Mastorakos G., Chrousos, G.P. (1993) The Pituitary Corticotroph is not the Rate Limiting Step in the Postoperative Recovery of the Hypothalamic-pituitary-adrenal Axis in Patients with Cushing's Syndrome. J. Clin. Endocrinol. Metab. 77:173-77. 210. Vamvakopoulos N.C., Chrousos G.P. (1993) Regulated Activity of the Distal Promoter-like Element of the Human Corticotropin-Releasing Hormone Gene and Secondary Structural Features of its Corresponding Transcripts. Mol. Cell. Endocrinol. 94:73-78. 211. Mastorakos G., Webster E.L., Friedman T.C., Chrousos G.P. (1993) Immunoreactive Corticotropin Releasing Hormone (CRH) and its Binding Sites in the Rat Ovary. J. Clin. Invest. 92:961-968. 212. Vamvakopoulos N.C., Fukuhara K., Patchev V.K., Chrousos G.P. (1993) Effect of Single and Repeated Immobilization Stress on the Heat Shock Protein (HSP) 70/90 System in the Rat: Glucocorticoid- Independent, Reversible Reduction of HSP90 in the Liver and Spleen. Neuroendocrinology 57:1057-1065. 213. Yanovski J.A., Yanovski S.Z., Gold P.W., Chrousos G.P., (1993) Differences in the Hypothalamic- 23

George P. Chrousos, M.D. Pituitary-Adrenal Axis of Black and White Women. J. Clin. Endocrinol. Metabol. 77:536-541. 214. Yanovski J.A., Cutler G.B., Doppman J.L., Miller D.L., Chrousos G.P., Oldfield E.H., Nieman L.K. (1993) The Limited Ability of Inferior Petrosal Sinus Sampling with Corticotropin-Releasing Hormone in Distinguishing Cushing Disease from Pseudo-Cushing States or Normal Physiology. J. Clin. Endocrinology. Metab. 77:503-509. 215. Vamvakopoulos N.C., Chrousos G.P., Griffin C.A., Hawkins A.L., Lee C., Jabs E.W. (1993) Mapping the Intron-containing Human hsp 90 (hspCAL4) Gene to Chromosome 14G32. Cytogenet Cell Gen. 64:224- 226. 216. Bouzas E.A., Scott M.H., Mastorakos S.G., Gold P.W., Chrousos G.P., Kaiser-Kupfer M.I. (1993) Central Serous Chorioretinopathy in Endogenous Hypercortisolism. Arch. Ophthalmol. 111:1229-33. 217. Vamvakopoulos N.C., Chrousos G.P. (1993) Evidence of Direct Estrogen Regulation of Human Corticotropin Releasing Hormone Gene Expression: Potential Implications for the Sexual Dimorphism of the Stress Response and Immune/Inflammatory Reaction. J. Clin. Invest. 92:1896-1902. 218. Patchev V.K., Mastorakos G., Brady L.S., Redwine J., Wilder R.L., and Chrousos G.P. (1993) Increased Arginine Vasopressin Secretion May Participate in the Enhanced Susceptibility of Lewis Rats to Inflammatory Disease. Neuroendocrinology. 58:106-110. 219. Reincke M., Karl M., Travis W., Chrousos G.P. (1993) No Evidence for Oncogenic Mutations in Guanine Nucleotide Binding Proteins of Human Adrenocortical Neoplasms. J. Clin. Endocrin. Metabol. 77:1419- 1422. 220. Tsigos C., Arai K., Hung W., Chrousos G.P. (1993) Hereditary Isolated Glucocorticoid Deficiency is Associated with Abnormalilties of the Adrenocorticotropin Receptor Gene. J. Clin. Invest. 92:2461-2485. 221. Vamvakopoulos N.C., Durkin S., Nierman W., Chrousos G.P. (1993) Mapping the Human Adrenocorticotropin Hormone (ACTHR) Gene to the Small Arm of Chromosome 18 (18p. 11.21- pter.) Genomics 18:454-455. 222. Gallucci W.T., Baum A., Laue L., Rabin D.S., Chrousos G.P., Gold P.W., Kling M.A. (1993) Sex Differences in Sensitivity of the Hypothalamic-Pituitary Adrenal Axis. Health Psychology 12:420-425. 223. Mastorakos G., Chrousos G.P., Weber J. (1993) Recombinant Interleukin 6 Activates the Hypothalamic- Pituitary-Adrenal Axis in Humans. J. Clin. Endocrinol. Metab. 27:1690-1694. 224. Reincke M., Allolio B., Petzke F., Heppner C., Mbulamberi D., Winklemann W., Chrousos G.P. (1993) Thyroid Dysfunction in African Trypanosomiasis: Evidence for Cytokine-Mediated Hypothyroidism. Clin. Endocrinol. 39:455-461. 225. Nieman L.K., Oldfield E.H., Wesley R., Chrousos G.P., Loriaux D.L., Cutler G.B. Jr., (1993) A simplified Morning Ovine Corticotropin-Releasing Hormone Stimulation Test for the Differential Diagnosis of ACTH-dependent Cushing's Syndrome. J. Clin. Endocrinol. Metab.77:1308-1312. 226. Reincke M. Allolio B., Arlt W., Heppner C., Petcke F., Mbulamberi D., Siekman L., Vollmer D., Winkleman W., Chrousos G.P. (1994) Impairment of Adrenocortical Function Associated with Increased Plasma Tumor Necrosis Factor-alpha and Interleukin-6 Concentrations in African Trypanosomiasis. NeuroImmunoModulation 1:14-22. 227. Doppman J., Nieman L.K., Cutler G.B. Jr., Chrousos G.P., Fraker D.L., Norton J.A., Jensen R.T. (1994) Adrenocorticotropin Hormone-Secreting Islet Cell Tumors: Are They Always Malignant? Radiology 24

George P. Chrousos, M.D. 190:59-64. 228. Zeiger M.A., Fraker D.L., Pass H.I., Nieman L.K., Cutler G.B. Jr., Chrousos G.P., Norton J.A. (1993) Effective Reversibility of the Signs and Symptoms of Hypercorticosolism by Bilateral Adrenalectomy. Surgery 114:1138-43. 229. Bouzas E.A., Mastorakos G., Friedman T.C., Scott M.H., Chrousos G.P., Kaiser-Kupfer M.I. (1993) Posterior Subcapsular Cataract in Endogenous Cushing Syndrome: An Uncommon Manifestation. Invest. Ophthalmol. Vis. Sci. 34:3497-3500. 230. Magiakou M.A., Mastorakos G., Gomez M.T., Rose S.R., Chrousos G.P. (1994) Suppressed Spontaneous and Stimulated Growth Hormone Secretion in Patients with Cushing Disease Before and After Surgical Cure. J. Clin. Endocrinol. Metab. 78:131-137. 231. Zelazowski P., Patchev V.K., Zelazowski E.B., Chrousos G.P., Gold P.W., Sternberg E.M. (1993) Release of Hypothalamic Corticotropin-Releasing Hormone and Arginine Vasopressin by Interleukin-1 and -MSH: Studies in Rats with Different Susceptibility to Inflammatory Disease. Brain Res. 631:22-26. 232. Ram Z., Nieman L.K., Cutler G.B. Jr., Chrousos G.P., Doppman J., Oldfield E.H. (1994) Early Repeat Surgery for Persistent Cushing's Disease. J. Neurosurg. 80:37-45. 233. Patchev V.K., Karalis K., Chrousos G.P. (1994) Effect of Excitatory Amino Acid Transmitters on Hypothalamic Corticotropin-Releasing Hormone (CRH) and Arginine Vasopressin Release: Implications for Pituitary-Adrenal Regulation. Brain Res. 633:312-316. 234. Vamvakopoulos N.C., Chrousos G.P. (1993) Structural Organization of the 5' Flanking Region of the Human Corticotropin Releasing Hormone Gene. J DNA Sequencing and Mapping 4:197-206. 235. DeBellis M., Chrousos G.P., Dorn L., Burke L., Helmers K., Kling M.A., Trickett P.K., Putnam F.W. (1994) Hypothalamic-Pituitary-Adrenal Axis Dysregulation in Sexually Abused Girls. J. Clin Endocrinol. Metab. 78:249-255. 236. Kling M., Demitrack M., Whitfield H. Jr., Kalogeras K., Listwak S., DeBellis M., Chrousos G.P., Gold P.W., Brandt H. (1993) Effects of the Glucocorticoid Antagonist RU 486 on Pituitary-Adrenal Function in Patients with Anorexia Nervosa and Healthy Volunteers: Enhancement of Plasma ACTH and Cortisol Secretion in Underweight Patients. Neuroendocrinol. 57:1082-1091. 237. Reincke M., Karl M., Travis W., Mastorakos G., Allolio B., Linehan M.H., Chrousos G.P., (1994) P53 Mutations in Human Adrenocortical Neoplasms: Immunohistochemical and Molecular Studies. J. Clin. Endocrinol. Metab. 78:790-794. 238. Cizza G., Kalogeras A.E., Brady L.S., Bagdy G., Bergamini E., Blackman M.R., Chrousos G.P., Gold P.W. (1994) Male 344 Fischer Rats Show a Progressive Central Impairment of the Hypothalamic-Pituitary- Adrenal-Axis with Advancing Age. Endocrinology 134:1611-1620. 239. Friedman T.C., Garcia-Borreguero D., Hardwick D., Akuete C.N., Stambuk M.K., Dorn G.B.Jr., Nieman L.K., Chrousos G.P. (1994) Diurnal Rhythm of Plasma Delta Sleep-Inducing Peptide in Humans: Evidence for Positive Correlation with Body Temperature and Negative Correlation with REM Slow Wave Sleep. J. Clin. Endocrin. & Metab. 78:1085-1089. 240. Karalis K., Mastorakos G., Chrousos G.P., Tolis G. (1994) Somatostatin Analogs Suppress the Inflammatory Reaction In Vivo. J. Clin. Invest. 93:2000-2006. 241. Kawatito Y., Sano H., Kawata M., Yuri K., Yamamura Y., Kato H., Chrousos G.P., Wilder R.L., Kondo M. 25

George P. Chrousos, M.D. (1994) Local Secretion of Corticotropin Releasing Hormone by Enterochromafin Cells in Human Colon. Gastroenterology 106:859-65. 242. Magiakou M.A., Mastorakos G., Oldfield E.H., Gomez M.T., Doppman J.L., Cutler G.B. Jr., Nieman L.K., Chrousos G.P. (1994) Cushing Syndrome in Children and Adolescents: Presentation, Diagnosis and Therapy. N. Engl. J. Med. 331:629-36. 243. Auchus R.J., Mastorakos G., Friedman T.C., Chrousos G.P. (1994) Corticotropin-Releasing Hormone Production by a Small Cell Carcinoma in a Patient with ACTH-dependent Cushing Syndrome. J. Endocrinol. Invest. 17:447-452. 244. Petrides J.S., Mueller G.P., Kalogeras K.T., Chrousos G.P., Gold P.W., Deuster P.A. (1994) Exercise- induced Activation of the Hypothalamic-Pituitary-Adrenal Axis: Marked Differences in the Sensitivity to Glucocorticoid Suppression. J. Clin. Endocrinol. Metab. 79:377-383. 245. Riddick L., Chrousos G.P., Jeffries S., Pang S. (1994) Comparison of Adrenocorticotropin and Adrenal Steroid Response to Corticotropin Releasing Hormone Versus Metyrapone Testing in Patients with Hypopituitarism. Pediatric Research 36:215-220. 246. Scopa C.D., Mastorakos M., Friedman T.C., Melachrinou M.C., Merino M.J., Chrousos G.P. (1994) Presence of Immunoreactive Corticotropin Releasing Hormone (CRH) in Thyroid Lesions. Am. J. Pathology 145:1159-1167. 247. Michelson D., Stone L., Galliven E., Magiakou M.A., Chrousos G.P., Sternberg E.M., Gold P.W. (1994) Multiple Sclerosis is Associated with Alterations in Hypothalamic-Pituitary-Adrenal Function. J. Clin. Endocrinol. Metab. 79:848-853. 248. Arai K., Tsigos C., Suzuki Y., Irony I., Karl M., Listwak S., Chrousos G.P. (1994) Physiological and Molecular Aspects of Mineralocorticoid Receptor Action in Pseudohypoaldosteronism: A Responsiveness Test and Therapy. J. Clin. Endocrinol. Metab. 79:1019-1023. 249. Mastorakos G., Scopa C., Friedman T., Vryonidou A., Kattis D., Phenekos K., Chrousos G.P. (1994) Presence of Immunoreactive Corticotropin Releasing Hormone in Normal and Polycystic Human Ovaries. J. Clin. Endocrinol. Metab. 79:934-939. 250. Mastorakos G., Weber J.S., Magiakou M.A., Gunn H., Chrousos G.P. (1994) Hypothalamic-Pituitary- Adrenal Axis Activation and Stimulation of Systemic Vasopressin Secretion by Recombinant Interleukin 6 in Humans: Potential Implications for the Syndrome of Inappropriate Vasopressin Secretion. J. Clin. Endocrinol. Metab. 79:1191-1197. 251. Magiakou M.A., Mastorakos G., Chrousos G.P. (1994) Final Stature in Patients with Endogenous Cushing Syndrome. J. Clin. Endocrinol. Metab. 79:1082-1085. 252. Patchev V.K., Brady L.S., Karl M., Chrousos G.P. (1994) Gene Expression of hsp90 and Glucocorticoid Receptors in the Brain: Evidence for Coordinate Regulation by Adrenal Steroid Levels In Vivo. Cell. Mol. Endocrinol. 103:57-64. 253. Stratakis C.A., Chrousos, G.P. (1994) Capillaritis (Purpura Simplex) Associated with Use of Aminoglutethimide in Cushing's Syndrome. Am. J. Hospital Pharmacy 51:2589-2591. 254. Beuschlein F., Reincke M., Karl M., Travis W.D., Jaursch-Hancke C., Abdelhamid S., Chrousos G.P., Allolio B. (1994) Clonal Composition of Human Adrenocortical Neoplasms. Cancer Research 54:4927- 4932. 26

George P. Chrousos, M.D. 255. Bernadini R., Chiarenza A., Kamilaris T.C., Renaud N., Lempereur L., Demitrack M., Gold P.W., Chrousos, G.P. (1994) In Vivo and In Vitro Effects of Arginine-Vasopressin Receptor Antagonists on the Hypothalamic-Pituitary-Adrenal Axis in the Rat. Neuroendocrinology 60:503-508. 256. Friedman T., Garcia D.B., Hardwick D., Akuete C., Doppman J., Dorn L., Barker C., Chrousos G.P. (1994) Decreased Delta Sleep and Plasma Delta Sleep-Inducing Peptide Immunoreactivity in Patients with Cushing Syndrome. Neuroendocrinology 60:626-634. 257. Crofford L.J., Pillemer S.R., Kalogeras K.T., Cash J.M., Michelson D., Kling M.A., Sternberg E.M., Gold P.W., Chrousos G.P., Wilder R.L. (1994) Hypothalamic-Pituitary-Adrenal-Axis Perturbation in Patients with Fibromyalgia. Arthritis and Rheumatism 37:1583-1592. 258. Michelson D., Chrousos G.P., Gold P.W. (1994) Type I Glucocorticoid Receptor Blockade Does Not Affect Baseline or Ovine Corticotropin-Releasing Hormone-Stimulated Adrenocorticotropic Hormone and Cortisol Secretion. NeuroImmunoModulation 1:274-277. 259. Mastorakos G., Cizza G., Kvetnansky R., Bergamini E., Blackman M.R., Gold P.W., Chrousos G.P. (1995) Aging and Acute Stress Decrease Corticotropin Releasing Hormone in the Ovary of the Fischer 344/N Rat. Life Sciences 56:1065-1071. 260. Latronico A.C., Reincke M., Mendonca B.B., Arai K., Mora P., Allolio B., Wajchenberg B.L., Chrousos, G.P., Tsigos C. (1995) No Evidence for Oncogenic Mutations in the Adrenocorticotropin Receptor (ACTH-R) Gene in Human Adrenocortical Neoplasms. J. Clin. Endocrinol. Metab. 80:875-877. 261. Arai K., Tsigos C., Suzuki Y., Listwak S., Zachman K., Zangeneh F., Rapaport R., Chanoine J.P., Chrousos G.P. (1995) No Apparent Mineralocorticoid Receptor Defect in a Series of Sporadic Cases of Pseudohypoaldosteronism. J. Clin. Endocrinol. Metab. 80:814-817. 262. Cizza G., Pacak K., Kvetnansky R., Palkovits M., Goldstein D.S., Brady L.S., Fukuhara K., Bergamini E., Kopin I.J., Blackman M.R., Chrousos G.P., Gold P.W. (1995) Decreased Stress Responsivity of the Central and Peripheral Catecholaminergic Systems in the Aged 344/N Fischer Rat. J. Clin. Invest. 95:1217-1224. 263. Heinrichs C., Deschepper J., Tsigos C., Drews R., Collu R., Dugardeyn C., Goyens P., Ghanem G.E., Bosson D., Chrousos G.P., Van Vliet G. (1995) Familial Adrenocorticotropin Unresponsiveness Associated with Alacrima and Achalasia: Biochemical and Molecular Studies in Two Siblings with Clinical Heterogeneity. European J. Peds. 154:191-196. 264. Bamberger C.M., Bamberger A.M., De Castro M., Chrousos G.P. (1995) Glucocorticoid Receptor- Beta, a Potential Endogenous Inhibitor of Glucocorticoid Action in Humans. J. Clin. Invest. 95:2435-2441. 265. Tsigos C., Arai K., Latronico A-C, DiGeorge A., Rapaport R., Chrousos G.P. (1995) A Novel Mutation of the Adrenocorticotropin Receptor (ACTH-R) Gene in a Family with the Syndrome of Isolated Glucocorticoid Deficiency but No ACTH-R Abnormalities in Two Families with Triple A Syndrome. J. Clin. Endocrinol. Metab. 80:2186-2189. 266. Mastorakos G., Patchev V.K., Chader G.J., Chrousos G.P., Gaudet S.J. (1995) Differences in arylakylamine N-Acetyltransferase Activity Between Inflammatory Disease-Susceptible Lewis and - Resistant Fischer Rats. Neuroendocrinology 62:71-78. 267. Doppman J.L., Nieman L.K., Chang R., Yanovski J.A., Cutler G.B. Jr., Chrousos G.P., Oldfield E.H. (1995) Selective Venous Sampling from the Cavernous Sinuses is not a More Reliable Technique than Sampling from the Inferior Petrosal Sinuses in Cushing Syndrome. J. Clin. Endocrinol. Metab. 80:2485- 2489. 27

George P. Chrousos, M.D. 268. Karalis K., Crofford L., Wilder R.L., Chrousos G.P. (1995) Glucocorticoid and/or Glucocorticoid Antagonist Effects in Inflammatory Disease-Susceptible Lewis and -Resistant Fischer Rats. Endocrinology 136:3107-3112. 269. Karalis K., Mastorakos G., Sano H., Davis C., Wilder R.L., Chrousos G.P. (1995) Somatostatin May Participate in the Antiinflammatory Actions of Glucocorticoids. Endocrinology 136:4133-4138. 270. Pacak K., McCarty R, Palkovitz M., Cizza G., Kopin I.J., Goldstein D., Chrousos G.P. (1995) Decreased Central and Peripheral Catecholaminergic Activation in Obese Zucker Rats. Endocrinology 136:4360- 4367. 271. Mastorakos G., Bouzas E., Caspi R., Friedman T., Chrousos G.P. (1995) Immune Corticotropin Releasing Hormone (CRH) is Present in the Eyes of and Promotes Experimental Autoimmune Uveoretinitis (EAU) in Rodents. Endocrinology 136:4650-4658. 272. Stratakis C.A., Mitsiadis N.S., Sun D., Chrousos G.P., O'Connell A. (1995) Recurring Oral Giant Cell Lesion in X-Linked Hypophosphatemic Rickets: Clinical Manifestation of Occult Hyperparathyroidism? J. Pediatrics 127:444-446. 273. Vgontzas A.N., Friedman T.C., Chrousos G.P., Bixler E.O., Vela-Bueno A., Kales A. (1995) Delta Sleep- Inducing Peptide in Normal Humans and in Patients with Sleep Apnea and Narcolepsy. Peptides 16:1153- 1156. 274. Dorn L.D., Burgess E.S., Dubbert B., Kling M., Gold P.W., Chrousos G.P. (1995) Psychopathology in Patients with Endogenous Cushing Syndrome: "Atypical" or "Melancholic" Features. Clin. Endocrinol. (Oxf.) 43:433-442. 275. Cizza G., Gold P.W., Chrousos G.P. (1995) The Stress-Induced Inhibition of the Hypothalamic- Pituitary- Thyroid Axis is Attenuated in the Aged Fischer 344/N Male Rat. Neuroendocrinology 62:506-13. 276. Theoharides T.C., Spanos C., Pang Z., Alferes L., Ligris K., Letourneau R., Rozniecki J.J., Webster E., Chrousos G.P. (1995) Stress-Induced Intracranial Mast Cell Degranulation. A Corticotropin-Releasing Hormone-Mediated Effect. Endocrinology 136:5745-50. 277. Yanovski J.A., Yanovski S.Z., Harrington L., Gold P., Chrousos G.P. (1995) Differences in the Hypothalamic-Pituitary-Adrenal Axis of Black and White Men. Hormone Research 44:208-212. 278. Chen H., Doppman J.L., Chrousos G.P., Norton J.A., Nieman L.K., Udelsman R. (1995) ACTH- Secreting Pheochromocytomas: The Exception to the Rule. Surgery 118:988-995. 279. Yu K.C., Alexander H.R., Ziessman H.A., Norton J.A., Buell J.F., Nieman L.K., Cutler Jr G.B., Chrousos G.P., Fraker D.L. (1995) The Role of Pre-Operative Iodocholesterol Scintiscanning in Patients Undergoing Adrenalectomy for Cushing's Syndrome. Surgery 118:981-987. 280. Amikura K., Alexander R.H., Norton J.A., Doppman J.L., Jensen R.T., Nieman L.K., Cutler G.B., Chrousos G.P., Fraker D.L. (1995) The Role of Surgery in Management of ACTH-Producing Islet Cell Tumors of the Pancreas. Surgery 118:1125-1130. 281. Kawahito Y., Sano H., Mukai S., Asai K., Kimura S., Yamamura Y., Kato H., Chrousos G.P., Wilder R.L., Kondo M. (1995) Corticotropin Releasing Hormone in Colonic Mucosa in Patients with Ulcerative Colitis. GUT 37:544-551. 282. Stratakis C.A., Carney A., Ping J., Papanicolaou D.A., Karl M., Kastner D.L., Pras E., Chrousos G.P. (1996) Carney Complex, a Familial Multiple Neoplasia and Lentiginosis Syndrome: Analysis of 11 28

George P. Chrousos, M.D. Kindreds and Linkage to the Short Arm of Chromosome 2. J. Clin. Invest. 97:699-705. 283. Karl M., Von Wichert G., Kempter E., Katz D.A., Reincke M., Monig H., Ali I.U., Stratakis C.A., Oldfield E.H., Chrousos G.P., Schulte H.M. (1996) Nelson's Syndrome Associated with a Somatic Frame Shift Mutation in the Glucocorticoid Receptor Gene. J. Clin. Endocrinol. Metab. 81:124-129. 284. Ghizzoni L., Mastorakos G., Vottero A., Magiakou M.A., Chrousos G.P., Bernasconi S. (1996) Spontaneous Cortisol and Growth Hormone Secretion Interactions in Patients with Nonclassic 21- Hydroxylase Deficiency (NCCAH) and Control Children. J. Clin. Endocrinol. Metab. 81:482-487. 285. Latronico A.C., Anasti J., Arnhold I.J.P., Rapaport R., Mendonca B.B., Bloise W., de Castro M., Tsigos G., Chrousos G.P. (1996) Testicular and Ovarian Resistance to Luteinizing Hormone Caused by Homozygous Inactivating Mutations of the Luteinizing Hormone Receptor Gene. N. Engl. J. Med. 334:507-512. 286. Johnson E.O., Decker L., Gold P.W., Chrousos G.P. (1996) Distribution of Hippocampal Mineralocorticoid and Glucocorticoid Receptor mRNA in a Glucocorticoid Resistant Nonhuman Primate. Steroids 61:69-73. 287. Petzke F., Heppner C., Mbulamberi D., Winkelmann W., Chrousos G.P., Allolio B., Reincke M. (1996) Hypogonadism in Rhodesian Sleeping Sickness: Evidence for Acute and Chronic Dysfunction of the Hypothalamic-Pituitary-Gonadal Axis. Fertility and Sterility 65:68-75. 288. Mastorakos G., Scopa C.D., Kao L.C., Vryonidou A., Friedman T.C., Kattis D., Phenekos C., Rabin D., Chrousos G.P. (1996) Presence of Immunoreactive Corticotropin Releasing-Hormone (CRH) in Human Endometrium. J. Clin. Endocrinol. Metab. 81:1046-1050. 289. Dorn L.D., Burgess E.S., Dichek H.L., Putnam F., Chrousos G.P., Gold P.W. (1996) Thyroid Hormone Concentrations in Depressed and Non-Depressed Adolescents: Group Differences and Behavioral Relations. J. Am. Acad. Child Adolesc. Psychiatry 35:299-306. 290. Leong, G.M., Mercado-Asis, L.B., Reynolds, J.C., Oldfield, E.H., Chrousos, G.P. (1996) The Effect of Cushing Disease on Bone Mineral Density, Body Composition, Growth and Puberty: A Report of an Identical Adolescent Twin Pair. J. Clin. Endocrinol. Metab. 81:1905-1911. 291. Magiakou, M.A., Mastorakos, G., Rabin, D., Dubbert, B., Gold, P.W., Chrousos, G.P. (1996) Hypothalamic Corticotropin Releasing Hormone Suppression during the Postpartum Period: Implications for the Increase of Psychiatric Manifestations during this Time. J. Clin. Endocrinol. Metab. 81:1912-1917. 292. Karl M., Saviolakis G.A., Gravanis A., Chrousos G.P., Margioris A.N. (1996) The PC 12 Rat Pheochromocytoma Cell Line Expresses the Prodynorphin Gene and Secretes the 8 kdalton Dynorphin Product. Regulatory Peptides 61:99-104. 293. Magiakou M.A., Mastorakos G., Rabin D., Margioris A.N., Dubbert B., Calogero A.E., Tsigos C., Munson P.J., Chrousos, G.P. (1996) The Maternal Hypothalamic-Pituitary-Adrenal Axis in Third Trimester Human Pregnancy. Clin. Endocrinol. (Oxf.) 44:419-428. 294. Kalogeras K.T., Nieman L.K., Friedman T.C., Dopppman J.L., Cutler G.B. Jr., Chrousos G.P., Wilder R.L., Gold P.W., Yanovski J.A. (1996) Inferior Petrosal Sinus Sampling in Normal Human Subjects Reveals a Unilateral Corticotropin-Releasing Hormone-Induced Arginine Vasopressin Release Associated with Ipsilateral Adrenal Corticotropin Secretion. J. Clin. Invest. 97:2045-2050 295. Johnson E.O., Kamilaris T.C., Calogero A.E., Gold P.W., Chrousos G.P. (1996) Effects of Early Parenting on Growth and Development in a Small Primate. Pediatric Research 39:999-1005. 29

George P. Chrousos, M.D. 296. Papanicolaou, D.A., Tsigos, C., Oldfield, E.H., Chrousos, G.P. (1996) Acute Glucocorticoid Deficiency is Associated with Plasma Elevation of Interleukin-6: Does the Latter Participate in the Symptomatology of the Steroid Withdrawal Syndrome and Adrenal Insufficiency? J. Clin. Endocrinol. Metab. 81:2303-2306. 297. Dorn L.D., Burgess E.S., Susman E.J., Von Eye A., DeBellis M.D. Gold P.W., Chrousos G.P. (1996) Response to Ovine Corticotropin Releasing Hormone in Depressed and Nondepressed Adolescents: Does Gender Make a Difference? J. Am. Acad. Child Adolesc. Psychiatry 35:764-773. 298. Burgess E.S., Dorn L.D., Haaga D., Chrousos G.P.. (1996) Sociotropy, Autonomy, Stress and Depression in Cushing Syndrome. J. Nerv. Ment. Dis. 184:362-367. 299. Karl M., Lamberts S.W.J., Koper J.W., Katz, D.A., Huizenga N.E., Kino T., Haddad B.R., Hughes M.R., Chrousos G.P. (1996) Cushing's Disease Preceded by Generalized Glucocorticoid Resistance: Clinical Consequences of a Novel, Dominant-negative Glucocorticoid Receptor Mutation. Proc. Assn. Amer. Phys. 108:296-307. 300. Friedman, T.C., Nieman, L.K., Yanovski, J.A., Doppman, J.L., Cutler, G.B. Jr., Oldfield, E.H., Gold, P.W., Chrousos, G.P., Kalogeras, K.T. (1996) Inferior Petrosal Sinus Arginine Vasopressin Concentrations in Normal Volunteers and Patients with Cushing Disease. J. Clin. Endocrinol. Metab. 81:3068-3072. 301. Yanovski, J.A., Zelitch-Yanovski, S.A., Friedman, T.C., Loh Peng, Y., Jayasvasti, V., Cutler, G.B. Jr., Chrousos, G.P. (1996) Etiology of the Differences in Corticotropin-Releasing Hormone-Induced ACTH Secretion of Black and White Women. J. Clin. Endocrinol. Metab. 81:3307-3311. 302. Makrigiannakis A., Zoumakis E., Margioris A.N., Stournaras C., Chrousos G.P., Gravanis A. (1996) Regulation of the Promoter of the Human Corticotropin-Releasing Hormone (CRH) Gene in Transfected Human Endometrial Cells. Neuroendocrinology 64:85-92. 303. DeMarco, L., Stratakis, C.A., Boson, W.L., Jakbovitz, O., Carson, E., Andrade, L.M., Amaral, V.F., Rocha, J.L., Chrousos, G.P., Nordenskjöld, M., Friedman, E. (1996) Sporadic Cardiac Myxomas and Tumors from Patients with Carney Complex are not Associated with Activating Mutations of the Gs Gene. Hum. Genet. 98:185-188. 304. Papanicolaou D.A., Petrides J.S., Tsigos C., Bina S., Kalogeras K.T., Wilder R., Gold P.W., Deuster P.A., Chrousos G.P. (1996) Exercise Stimulates Interleukin-6 Secretion: Inhibition By Glucocorticoids and Correlation With Catecholamines. Am. J. Physiol. E601-E605. 305. Johnson E.O., Kamilaris T.C., Carter C.S., Calogero A.E., Gold P.W., Chrousos G.P. (1996) The Biobehavioral Consequences of Psychogenic Stress in a Small, Social Primate (Callithrix jacchus jacchus). Biol. Psychiatry 40:317-337. 306. Castro M., Elliot S., Kino T., Bamberger C., Karl M., Webster E., Chrousos G.P. (1996) The Nonligand Binding -Isoform of the Human Glucocorticoid Receptor (hGR): Tissue Levels, Mechanism of Action and Potential Physiologic Role. Mol. Med. 2:597-607. 307. Yanovski J.A., Yanovski S.Z., Cutler G.B. Jr., Chrousos G.P., Filmer K. (1996) Differences in the Hypothalamic-Pituitary-Adrenal Axis of African American and Caucasian Girls. J. Pediatrics 129:130- 136. 308. Cizza G., Nieman L.K., Doppman J.L., Passaro M.D., Czerwiec F.S., Chrousos G.P., Cutler G.B. Jr. (1996) Factitious Cushing Syndrome. J. Clin. Endocrinol. Metab. 81:3573-3577. 309. Stratakis C.A., Jenkins R.B., Pras E., Mitsiadis C.S., Raff S.B., Stalboerger P.G., Tsigos C., Carney A., Chrousos G.P. (1996) Cytogenetic and Mircosatellite Alterations in Tumors from Patients with the 30

George P. Chrousos, M.D. Syndrome of Myxomas, Spotty Skin Pigmentation, and Endocrine Overactivity (Carney Complex). J. Clin. Endocrinol. Metab. 81:3607-3614. 310. Reincke M., Wachenfeld C., Mora P., Thumser A., Jaursch-Hancke C., Abdelhamid S., Chrousos G.P., Allolio B. (1996) p53 Mutations in Adrenal Tumors: Caucasian Patients Do Not Show the Exon 4 "Hot Spot" Found in Taiwan. J. Clin. Endocrinol. Metab. 81:3636-3638. 311. Michelson, D., Stratakis, C., Hill, L.Y., Reynolds, J., Galliven, E., Chrousos, G.P., Gold, P.W. (1996) Bone Mineral Density is Decreased in Women With Depression. N. Engl. J. Med. 335:1176-1181. 312. Elenkov I.J., Papanicolaou D.A., Wilder R.L., Chrousos G.P. (1996) Modulatory Effects of Glucocorticoids and Catecholamines on Human Interleukin-12 and Interleukin-10 Production: Clinical Implications. Proc. Assn. Am. Phys. 108:374-381. 313. Stratakis C.A., Chrousos G.P. (1996) Transient Elevation of Serum Thyroid Hormone Levels Following Lithium Discontinuation. Eur. J. Peds. 155:939-941. 314. Wong M., Ramayya M.S., Chrousos G.P., Driggers P.H., Parker K.L. (1996) Cloning and Sequencing Analysis of the Human Gene Encoding Steroidogenic Factor 1. J. Mol. Endocrinol. 17:139-147. 315. Webster E.L., Lewis D.B., Torpy D.J., Zachman E.K., Rice K.C., Chrousos G.P. (1996) In Vivo and In Vitro Characterization of Antalarmin, a Nonpeptide Corticotropin-Releasing Hormone (CRH) Receptor Antagonist: Suppression of Pituitary ACTH Release and Peripheral Inflammation. Endocrinology 137:5747-5750. 316. Cizza G., Brady L.S., Esclapes M., Blackman M.R., Gold P.W., Chrousos G.P. (1996) Age and Gender Influence Basal and Stress-Modulated Hypothalamic-Pituitary-Thyroidal Function in Fischer 344/N Rats. Neuroendocrinology 64:440-448. 317. Stratakis C.A., Orban Z., Burns A.L., Vottero A., Mitsiades C.S., Marx S.J., Abbassi V., Chrousos G.P. (1996) Dideoxyfingerprinting (ddF) Analysis of the Type X Collagen Gene (COL10A1) and Identification of a Novel Mutation (S671P) in a Kindred with Schmid Metaphyseal Chondrodysplasia. Biochem. Mol. Med. 59:112-117. 318. Friedman T.C., Mastorakos G., Newman T.D., Mullen N.M., Horton E.G., Costello R., Papadopoulos N.M., Chrousos G.P.. (1996) Carbohydrate and Lipid Metabolism in Endogenous Hypercortisolism: Shared Features with Metabolic Syndrome X and Noninsulin-Dependent Diabetes Mellitus. Endocrine Journal 43:645-656. 319. Stratakis C.A., Mitsiades N.S., Chrousos G.P., Margioris A.N. (1996) Dopamine Affects Rat Placenta Opioids in Receptor- and Opioid Type-Specific Manner. Eur. J. Pharmacol. 315:53-58. 320. Oberfield S.E., Nirenberg A., Allen J.C., Cohen H., Donahue B., Prasad V., Schiff R., Pang S., Ghavimi F., David., Chrousos G.P., Sklar C. (1997) Hypothalamic-Pituitary-Adrenal Function Following Cranial Irradiation. Horm. Res. 47:9-16. 321. Susman E., Dorn L., Inoff-Germain G., Nottelmann E., Chrousos G.P. (1997) Cortisol Reactivity, Distress Behavior, and Behavioral and Psychological Problems in Young Adolescents: A Longitudinal Perspective. J. Res. Adolescence 7:81-105. 322. Dorn L.D., Burgess E.S., Friedman T.C., Dubbert B., Gold P.W., Chrousos G.P. (1997) The Longitudinal Course of Psychopathology in Cushing Syndrome After Correction of Hypercortisolism. J. Clin. Endocrinol. Metab. 82:912-919. 31

George P. Chrousos, M.D. 323. Sarlis N.J., Chrousos G.P., Doppman J.L., Carney J.A., Stratakis C.A. (1997) Primary Pigmented Nodular Adrenocortical Disease: Reevaluation of a Patient with Carney Complex 27 Years After Unilateral Adrenalectomy. J. Clin. Endocrinol. Metab. 82:1274-1278. 324. Crofford L.J., Kalogeras K.T., Mastorakos G., Magiakou M-A., Wells J., Kanik K.S., Gold P.W., Chrousos G.P., Wilder R.L. (1997) Circadian Relationships Between Interleukin (IL)-6 and Hypothalamic-Pituitary-Adrenal Axis Hormones: Failure of IL-6 to Cause Sustained Hypercortisolism in Patients with Early Untreated Rheumatoid Arthritis. J. Clin. Endocrinol. Metab. 82:1279-1283. 325. Licinio J., Mantzoros C., Negrão A.B., Cizza G., Wong M-L, Bongiorno P.B., Chrousos G.P., Karp B., Ellen C., Flier J.S., Gold P.W. (1997) Human Leptin Levels are Pulsatile and Inversely Related to Pituitary-Adrenal Function. Nature Medicine 3:575-579. 326. Taymans S.E., DeVries A.C., DeVries M.B., Nelson R.J., Friedman T.C., Castro M., Detera-Wadleigh S., Carter C.S., Chrousos G.P. (1997) The Prairie Vole (Microtus ochrogaster) as a Model of Glucocorticoid Resistance. Gen. Comp. Endocrinol. 106:48-61. 327. Vgontzas A.N., Papanicolaou D.A., Bixler E.O., Kales A., Tyson K., Chrousos G.P. (1997) Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity. J. Clin. Endocrinol. Metab. 82:1313-1316. 328. Magiakou M.A., Mastorakos G., Zachman K., Chrousos G.P. (1997) Blood Pressure in Children and Adolescents with Cushing Syndrome Before and After Surgical Cure. J. Clin. Endocrinol. Metab. 82:1734- 1738. 329. Ramayya M.S., Zhou J., Kino T., Segars J.H., Bondy C.A., Chrousos G.P. (1997) Steroidogenic Factor-1 (hSF-1) mRNA Expression in Steroidogenic and Nonsteroidogenic Human Tissues: Northern Blot and In Situ Hybridization Studies. J. Clin. Endocrinol. Metab. 82:1799-1806. 330. Yanovski J.A., Yanovski S.Z., Gold P.W., Chrousos G.P. (1997) Differences in Corticotropin- Releasing Hormone-Stimulated Adrenocorticotropin and Cortisol Before and After Weight Loss. J. Clin. Endocrinol. Metab. 82:1874-1878. 331. de Lange P., Koper J.W., Huizenga N.A.T.M., Brinkman A.O., de Jong F.H., Cato A.C.B., Karl M., Chrousos G.P., Lamberts S.W.J. (1997) Differential Hormone-Dependent Transactivation and Transrepression by Naturally Occurring Human Glucocorticoid Receptor (GR) Variants. Mol. Endocrinol. 11:1156-1164 332. Premkumar A., Stratakis C.A., Shawker T.H., Papanicolaou D.A., Chrousos G.P. (1997) Testicular Ultrasound in Carney Complex: Report of Three Cases. J. Clin. Ultrasound. 25:211-214. 333. Petrides J.S., Gold P.W., Mueller G.P., Singh A., Stratakis C.A., Chrousos G.P., Deuster P.A. (1997) Marked Differences in Functioning of the Hypothalamic-Pituitary-Adrenal Axis Between Groups of Men. J. Appl. Physiol. 82:1979-1988. 334. Reincke M., Beuschlein F., Latronico A-C., Arlt W., Chrousos G.P., Allolio B. (1997) Expression of Adrenocorticotrophic Hormone Receptor mRNA in Human Adrenocortical Neoplasms: Correlation with P450scc Expression. Clin. Endocrinol. (Oxford) 46:619-626. 335. Michelson D., Galliven E., Hill L., Demitrack M., Chrousos G.P., Gold P. (1997) Chronic Imipramine is Associated with Diminished Hypothalamic-Pituitary-Adrenal Axis Responsivity in Healthy Humans. J. Clin. Endocrinol. Metab. 82:2601-2606. 336. Cizza G., Lotsikas A.J., Licinio J., Gold P.W., Chrousos G.P. (1997) Plasma Leptin Levels Do Not Change 32

George P. Chrousos, M.D. in Patients with Cushing’s Disease Shortly After Correction of Hypercortisolism. J. Clin. Endocrinol. Metab. 82:2747-2750. 337. Tsigos C., Papanicolaou D.A., Defensor R., Mitsiades C.S., Kyrou I., Chrousos G.P. (1997) Dose Effects of Recombinant Human Interleukin-6 on Piuitary Hormone Secretion and Energy Expenditure. Neuroendocrinology 66:54-62. 338. Bamberger C.M., Bamberger A., Wald M., Chrousos G.P., Schulte H.M. (1997) Inhibition of Mineralocorticoid Activity by the -Isoform of the Human Glucocorticoid Receptor. J. Steroid Biochem. and Mol. Biol. 60:43-50. 339. Arnold I.J.P., Latronico A.C., Batista M.C., Carvalho F.M., Chrousos G.P., Mendonca B.B. (1997) Ovarian Resistance to Luteinizing Hormone: A Novel Cause of Amenorrhea and Infertility. Fertil. Steril. 67:394-397. 340. Reincke M., Mora P., Beuschlein F., Arlt W., Chrousos G.P., Allolio B. (1997) Deletion of the Adrenocorticotropin Receptor Gene in Human Adrenocortical Tumors: Implications for Tumorigenesis. J. Clin. Endocrinol. Metab. 82:3054-3058. 341. Vgontzas A.N., Bixler E.O., Papanicolaou D.A., Kales A., Stratakis C.A., Vela-Bueno A., Gold P.W., Chrousos G.P. (1997) REM Sleep Correlates with the Overall Activities of the Hypothalamic- Pituitary- Adrenal (HPA) Axis and Sympathetic System in Healthy Humans. J. Clin. Endocrinol. Metab. 82:3278- 3280. 342. Ghizzoni L., Mastorakos G., Vottero A., Bareca A., Furlini M., Cesarone A., Ferrari B., Chrousos G.P., Bernasconi S. (1997) Corticotropin-Releasing Hormone (CRH) Inhibits Steroid Biosynthesis by Cultured Human Granulosa-Lutein Cells in a CRH and Interleukin-1 Receptor -Mediated Fashion. Endocrinology 138:4806-4811. 343. Yanovski J.A., Friedman T.C., Nieman L.K., Chrousos G.P., Cutler G.B. Jr., Doppman J.L., Kalogeras K.T. (1997) Inferior Petrosal Sinus AVP in Patients with Cushing’s Syndrome. Clin. Endocrinol. 47:199- 206. 344. Stratakis C.A., Sarlis N.J., Berrettini W.H., Badner J.A., Chrousos G.P., Gershon E.S., Detera- Wadleigh S.D. (1997) Lack of Linkage Between the Corticotropin-Releasing Hormone (CRH) Gene and Bipolar Affective Disorder. Mol. Psychiatry 2:483-485. 345. Ghizzoni L., Mastorakos G., Street M.E., Vottero A., Mazzardo G., Vanelli M., Chrousos G.P., Bernasconi S. (1997) Spontaneous Thyrotropin and Cortisol Secretion Interactions in Patients with Nonclassical 21- Hydroxylase Deficiency and Control Children. J. Clin. Endocrinol. Metab. 82:3677-3683. 346. Leung D.Y.M., Hamid Q., Vottero A., Szefler S.J., Surs W., Minshall E., Chrousos G.P., Klemm D.J. (1997) Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor. J. Exp. Med. 186:1567-1574. 347. Tsigos C., Papanicolaou D.A., Kyrou I., Defensor R., Mitsiadis C.S., Chrousos G.P. (1997) Dose- Dependent Effects of Recombinant Human Interleukin-6 on Glucose Regulation. J. Clin. Endocrinol. Metab. 82:4167-4170. 348. Stratakis C., Magiakou M.A., Mastorakos G., Oldfield E., Chrousos G.P. (1997) Thyroid Function in Children with Cushing Disease Before and After Transsphenoidal Surgery. J. Peds. 131:905-909. 349. Theoharides T.C., Singh L.K., Boucher W., Pang X., Letourneau R., Webster E., Chrousos G.P. (1998) Corticotropin-Releasing Hormone Induces Skin Mast Cell Degranulation and Increased Vascular 33

George P. Chrousos, M.D. Permeability, A Possible Explanation for Its Proinflammatory Effects. Endocrinology 139:403-413. 350. Bornstein S.R., Licinio J., Tauchnitz R., Engelmann L., Negrão A.B., Gold P.W., Chrousos G.P. (1998) Plasma Leptin Levels Are Increased in Survivors of Acute Stress: Associated Loss of Diurnal Rhythm in Cortisol and Leptin Secretion. J. Clin. Endocrinol. Metab. 88:280-283. 351. Yanovski J.A., Cutler G.B., Chrousos G.P., Nieman L.K. (1998) The Dexamethasone-Suppressed Corticotropin-Releasing Hormone Stimulation Test Differentiates Mild Cushing’s Disease from Normal Physiology. J. Clin. Endocrinol. Metab. 83:348-352. 352. Papanicolaou D.A., Yanovski J.A., Cutler G.B. Jr., Chrousos G.P., Nieman L.K. (1998) A Single Midnight Serum Cortisol Measurement Distinguishes Cushing’s Syndrome from Pseudo-Cushing States. J. Clin. Endocrinol. Metab. 83:1163-1167. 353. Stratakis C.A., Vottero A., Brodie A., Kirschner L.S., DeAtkine D., Lu Q., Yue W., Mitsiades C.S., Flor A.W., Chrousos G.P. (1998) The Aromatase Excess Syndrome is Associated with Feminization of Both Sexes and Autosomal Dominant Transmission of Aberrant P450arom Gene Transcription. J. Clin. Endocrinol. Metab. 83:1348-1357. 354. Bornstein S.R., Webster E.L., Torpy D.J., Richman S.J., Mitsiades N., Igel M., Lewis D.B., Rice K.C., Joost H.G., Tsokos M., Chrousos G.P. (1998) Chronic Effects of a Nonpeptide Corticotropin- Releasing Hormone Type 1-Receptor Antagonist on Pituitary-Adrenal Function, and Body Weight and Metabolic Regulation. Endocrinology 139:1546-1555. 355. Yanovski J.A., Nieman L.K., Doppman J.L., Chrousos G.P., Wilder R.L., Gold P.W., Kalogeras K.T. (1998) Plasma Levels of Corticotropin-Releasing Hormone in the Inferior Petrosal Sinuses of Healthy Volunteers, Patients with Cushing’s Syndrome, and Patients with Pseudo-Cushing States. J. Clin. Endocrinol. Metab. 83:1485-1488. 356. Gragerov A., Kino T., Ilyina-Gragerova G., Chrousos G.P., Pavlakis G.N. (1998) HHR23A, the Human Homologue of the Yeast Repair Protein RAD23 Interacts Specifically with Vpr Protein and Prevents Cell Cycle Arrest But Not the Transcriptional Effects of Vpr. Virology 245:323-330. 357. Stratakis C.A., Mastorakos G., Mitsiades N.S., Mitsiades C.S., Chrousos G.P. (1998) Skin Manifestations of Cushing Disease in Children and Adolescents Before and After the Resolution of Hypercortisolemia. Ped. Dermatol. 15:253-258. 358. Willenberg H.S., Stratakis C.A., Marx C., Ehrhart-Bornstein M., Chrousos G.P., Bornstein S.R. (1998) Aberrant Interleukin-1 Receptors in a Cortisol-Secreting Adrenal Adenoma Causing Cushing’s Syndrome. N. Engl. J. Med. 339:27-31. 359. Vgontzas A.N., Tsigos C., Kales A., Stratakis C.A., Zachman K., Bixler e.O., Velo-Bueno A., Chrousos G.P. (1998) Chronic Insomnia and Activity of the Stress System: A Preliminary Study. J. Psychosomatic Res. 45:21-31. 360. Elenkov I.J., Webster E.L., Papanicolaou D.A., Fleisher T.A., Chrousos G.P., Wilder R.L. (1998) Histamine Potently Suppresses Human Interleukin-12 and Stimulates Interleukin-10 Production via H2 Receptors. J. Immunol. 161:2586-2593. 361. Torpy D.J., Gordon R.D., Lin J-P., Huggard P.R., Taymans S.E., Stowasser M., Chrousos G.P., Stratakis C.A. (1998) Familial Hyperaldosteronism Type-II: Description of a Large Kindred and Exclusion of the Aldosterone Synthase (CYP11B2) Gene. J. Clin. Endocrinol. Metab. 83:3214-3218. 362. Torpy D.J., Tsigos C., Lotsikas A.J., Defensor R., Chrousos G.P., Papanicolaou D.A. (1998) Acute and 34

George P. Chrousos, M.D. Delayed Effects of a Single-Dose Injection of Interleukin-6 on Thyroid Function in Healthy Humans. Metabolism 47:1289-1293. 363. Chan E.C., Falconer J., Madsen G., Read M., Chrousos G.P., Webster E.L., Rice K., Smith R.A. (1998) Corticotropin-Releasing Hormone Type I Receptor Antagonist Delays Parturition in Sheep. Endocrinology139:3357-3360. 364. Longui C.A., Vottero A., Harris A.G., Chrousos G.P. (1998) Plasma Cortisol Responses After Intramuscular ACTH 1-24 in Healthy Men. Metabolism 47:1419-1422. 365. Glasow A., Haidan A., Hilbers U., Breidert M., Gillespie J., Scherbaum W.A., Chrousos G.P., Bornstein S.R. (1998) Expression of Ob Receptor in Normal Human Adrenals: Differential Regulation of Adrenocortical and Adrenomedullary Function by Leptin. J. Clin. Endocrinol. Metab. 83:4459-4466. 366. Torpy D.J., Bornstein S.R., Chrousos G.P. (1998) Leptin and Interleukin-6 in Sepsis. Horm. Metab. Res. 30:726-729. 367. Willenberg H.S, Bornstein S.R., Dumser T., Ehrhart-Bornstein M., Barocka A., Chrousos G.P., Scherbaum W.A. (1998) Morphological Changes in Adrenals From Victims of Suicide in Relation to Altered Apoptosis. Endocrine Research, 24:963-967. 368. Deuster P.A., Petrides J.S., Singh A., Lucci E.G., Chrousos G.P., Gold P.W. (1998) High Intensity Exercise Promotes Escape of ACTH and Cortisol From Suppression by Dexamethasone: Sexually Dimorphic Responses. J. Clin. Endocrinol. Metab., 83:3332-3338. 369. Kino T., Gragerov A., Kopp J.B., Stauber R.H., Pavlakis G.N., Chrousos, G.P. (1999) The HIV-1 Virion- associated Protein Vpr is a Coactivator of the Human Glucocorticoid Receptor. J. Exp. Med. 89:51-61. 370. Deak T., Nguyen K.T., Ehrlich A.L., Watkins L.R., Spencer R.L., Maier S.F., Licinio J., Wong M-L, Chrousos G.P., Webster E., Gold P.W. (1999) The Impact of the Nonpeptide CRH Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress. Endocrinology. 140:79-86. 371. Heino M., Scott H.S., Chen Q., Peterson P., Maenpaa U., Papasavvas M.P., Mittaz L., Barras C., Rossier C., Chrousos, G. P., Stratakis, C.A., Nagamine K., Kudoh J., Shimizu N., Maclaren N., Antonarakis S.E., and Krohn K. (1999) Mutation Analyses of North American APS-1 Patients. Human Mutation 13: 69-74. 372. Shahidi H., Vottero A., Stratakis, C.A., Taymans, S.E., Karl M., Longui, C.A., Chrousos, G.P.. Daughaday. W.H., Gregory, S.A., Plate, J.M.D. (1999) Imbalanced expression of the glucocorticoid receptor isoforms in cultured lymphocytes from a patient with systemic glucocorticoid resistance and chronic lymphocytic leukemia. Biochem Biophys Res Commun 254:559-565. 373. Vottero A, Stratakis CA, Ghizzoni L, Longui CA, Karl M., Chrousos G.P. (1999) Androgen receptor- mediated Hypersensitivity to Androgens in Women with Nonhyperandrogenic Hirsutism: Skewing of X- chromosome Inactivation. J. Clin. Endocrinol. Metab. 84:1091-1095. 374. Tataranni P.A., Cizza G., Snitker S., Gucciardo F., Lotsikas A., Chrousos G.P., Ravussin E., (1999) Hypothalamic-pituitary-adrenal Axis and Sympathetic Nervous System Activities in Pima Indians and Caucasians. Metabolism. 48:395-399. 375. Torpy, D. J., Chen, C., Mullen, N., Doppman, J. L., Carrasquillo, J., Chrousos G.P., Nieman, L. K. (1999) Lack of Utility of 111In-Pentetreotide Scintigraphy in Localizing Ectopic ACTH Producing Tumors: Follow-up of 18 Patients., J. Clin. Endocrinol. Metab. 84:1186-1192. 376. Singh A., Papanicolaou D.A., Lawrence L.L., Howell E.A., Chrousos G.P., Deuster P.A. (1999) 35

George P. Chrousos, M.D. Neuroendocrine Responses to Exhaustive Running in Women. Med. Sci. Sports Exerc. 31:536-542. 377. Torpy D.J., Webster E.L., Zachman E.K., Aguilera G., Chrousos G.P. (1999) Urocortin and Inflammation: Confounding Effects of Hypotension on Measures of Inflammation. Neuroimmunomodulation 6:182-186. 378. Susman E.J., Schmeelk K.H., Worrall B.K., Granger D.A., Ponirakis A., Chrousos G.P. (1999) Corticotropin Releasing Hormone and Cortisol: Longitudinal Associations with Depression and Antisocial Behavior in Pregnant Adolescents. J. Amer. Acad. Chid and Adol. Psychiatry 38:460-467. 379. Bottner A., Eisenhofer G., Torpy D.J., Ehrhart-Bornstein M., Keiser H.R., Chrousos G.P., Bornstein S.R. (1999) Lack of Leptin Suppression in Response to Hypersecretion of Catecholamines in Pheochromocytoma Patients. (Preliminary Report) Metabolism 48:543-545. 380. Hamid Q.A., Wenzel S.E., Hauk P.J., Tsicopoulos A., Wallaert B., Lafitte J-J., Chrousos G.P., Szefler S.J., Leung D.Y.M. (1999) Increased Glucocorticoid Receptor-beta in Airway Cells of Glucocorticoid- insensitive Asthma Am J Respir Crit Care Med 159:1600-1604. 381. Dorn L.D., Nottelmann E., Susman E.J., Inoff-Germain G., Cutler G.B. Jr., Chrousos G.P. (1999) Variability in Hormone Concentrations and Self-reported Menstrual Histories in Young Adolescents: Menarche as an Integral Part of a Developmental Process. J Youth & Adolescence 28:283-303. 382. Yanovski J.A., Miller K.D., Kino T., Friedman T.C., Chrousos G.P., Tsigos C., Falloon J. (1999) Endocrine and Metabolic Evaluation of HIV-infected Patients with Evidence of Protease Inhibitor Associated Lipodystrophy. J. Clin. Endocrinol. Metab. 84:1925-1931. 383. Orban, Z., Remaley, A.T., Sampson, M., Trajanoski, Z., Chrousos G.P. (1999) the Differential Effect of Food Intake and -Adrenergic Stimulation of Adipose-Derived Hormones and Cytokines in Man. J. Clin. Endocrinol. Metab. 84:2126-2133. 384. Singh, A., Petrides, J. S., Gold, P. W., Chrousos G.P., Deuster, P.A. (1999) Differential Hypothalamic- Pituitary-Adrenal Axis Reactivity to Psychological and Physical Stress, J. Clin. Endocrinol. 84:1944-1948. 385. Schmeelk, K. H., Granger, D. A., Susman, E. J., Chrousos G.P. (1999) Maternal Depression and Risk for Postpartum Complications in Adolescents: Role of Prenatal Corticotrophin-releasing Hormone and Interleukin-1 Receptor Antagonist., Behaviorial Medicine, 25:88-94. 386. Arai, K., Zachman, K., Shibasaki, T., Chrousos G.P. (1999) Polymorphisms of Amiloride Sensitive Sodium Channel Subunits in Five Sporadic Cases of Pseudohypoaldosteronism: Do They Have Pathologic Potential? J. Clin. Endocrinol. Metab., 84:2434-2437. 387. Franchimont, D., Louis, E., Dupont, P., Vrindts-Gevaert, Y., Dewe, W., Chrousos G.P., Geenen, V., Belaiche, J. (1999) Decreased Corticosensitivity in Quiescent Crohn’s Disease An Ex Vivo Study Using Whole Blood Cell Cultures, Digestive Diseases and Sciences, 44:1208-1215. 388. Wong, M., Webster, E. L., Spokes, H. Phu, P., Ehrhart-Bornstein, M., Bornstein, S., Park, C., Rice, K. C., Chrousos G.P., Licinio, J., Gold, P. W. (1999) Chronic Administration of the Non-Peptide CRH Type 1 Receptor Antagonist Antalarmin Does Not Blunt Hypothalamic-Pituitary-Adrenal Axis Responses to Acute Immobilization Stress, Life Sciences, 65:53-58. 389. Franchimont, D. Martens, H. Habelstein, M., Louis, E., Dewe, W., Chrousos G.P., Belaiche, J., Geenen, V. (1999) Tumor Necrosis Factor Decreases, and Interleukin-10 Increases, the Sensitivity of Human Monocytes to Dexamethasone: Potential Regulation of the Glucocorticoid Receptor, J. Clinical Endocrinology & Metabolism, 84:2834-2839. 36

George P. Chrousos, M.D. 390. Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Lotsikas, A., Zachman, K., Kales, A., Prolo, P., Wong, M., Licinio, J., Gold, P. W., Hermida, R. C., Mastorakos, G., Chrousos G.P., (1999) Circadian Interleukin- 6 Secretion and Quality and Depth of Sleep, J. Clinical Endocrinology & Metabolism, 84:2603-2607. 391. Vgontzas, A. N., Mastorakos, G., Bixler, E. O., Kales, A., Gold, P. W., Chrousos G.P., (1999) Sleep Deprivation Effects on the Activity of the Hypothalamic-Pituitary-Adrenal and Growth Axes: Potential Clinical Implications, Clinical Endocrinol. (Oxf.), 51:205-215. 392. Macrigiannakis, A., Margioris, A., Chrousos G.P., Stounaras, C., Gravanis, A., (1999) The Decidualizing Effect of Progesterone May Involve Direct Transcriptional Activation of Corticotropin Releasing Hormone (CRH) from Human Endometrial Stroma Cells, Molecular Human Reproduction, 5:789-796. 393. Kino T., Nordeen S.K., Chrousos G.P. (1999) Conditional Modulation of Glucocorticoid Receptor Activities by CREB-binding Protein (CBP) and p300. J. Steroid Biochem. Molec. Biol., 70:15-25. 394. Stratakis, C. A., Sarlis, N., Kirschner, L. S., Carney, J. A., Doppman, J. L., Nieman, L. K., Chrousos G.P., Papanicolaou, D. A., (1999) Paradoxic Response to Dexamethasone in the Diagnosis of Primary Pigmented Nodular Adrenocortical Disease, Ann. Intern. Med., 131:585-591. 395. Wolkersdorfer, G.W., Lohmann, T. Schroder, S., Marx, C., Pfeiffer, R., Stahl, H-D., Chrousos G.P., Bornstein, S.R., (1999) Lymphocytes Stimulate Dehydroepiandrosterone Production Through Direct Cellular Contact with Adrenal Zona Reticularis Cells: A Novel Mechanism of Immune-Endocrine Interaction, J. Clin. Endocrinol. Metab., 84:4220-4227. 396. Koch, C. A., Azumi, N., Furlong, M. A., Jha, R. C., Kehoe, T. E., Trowbridge, C. H., O’Dorisio, T. M., Chrousos G.P., (1999) Clement, S. C., CLINICAL CASE SEMINAR: Carcinoid Syndrome Caused by an Atypical Carcinoid of the Uterine Cervix, J. Clin. Endocrinol. Metab., 84:4208-4213. 397. Torpy, D. J., Webster, E. L., Zachman, E. K., Aguilera, G., Chrousos G.P., (1999) Urocortin and Inflammation: Confounding Effects of Hypotension on Measures of Inflammation, Neuroimmunomodulation, 6:182-186. 398. Tsigos C., Papanicolaou D., Kyrou I., and Chrousos G. P. (1999) Dose Effects of Recombinant Human Interleukin-6 on the Pituitary-testicular Axis. J. Interferon and Cytokine Res. 19:1271-6 399. Link, A. A., Kino, T. , Worth, J. A., McGuire, J. L., Crane, M. L., Chrousos G.P., Wilder, R. L., Elenkov, I. J., (2000) Ligand-Activation of the Adenosine A2a Receptors Inhibits IL-12 Production by Human Monocytes, J. Immunology, 164:436-442. 400. Orban, Z., Mitsiades, N., Burke, Jr., T. R., Tsokos, M., Chrousos G.P., (2000) Caffeic Acid Phenethyl Ester Induces Leukocyte Apoptosis, Modulates Nuclear Factor-Kappa B and Suppresses Acute Inflammation, Neuroimmunomodulation, 7:99-105. 401. Wong, M-L., Kling, M. A., Munson, P. J., Listwak, S., Licinio, J., Prolo, P., Karp, B., McCutcheon, I. E., Geracioti, Jr. T. D., DeBellis, M. D., Rice, K. C., Goldstein, D. S., Veldhuis, J. D., Chrousos G.P., Oldfield, E. H., McCann, S. M., Gold, P. W. (2000), Pronounced and Sustained Central Hypernoradrenergic Function in Major Depression with Melancholic Features: Relation to Hypercortisolism and Corticotropin Releasing Hormone, Proc. Natl. Acad. Sci, USA, 97:325-330. 402. Franchimont D., Galon J., Gadina M., Visconti R., Zhou Y., Aringer M., Frucht DM., Chrousos G.P., O’Shea JJ., (2000) Inhibition of Th1 Immune Response by Glucocorticoids: Dexamethasone Selectively Inhibits IL-12-induced Stat-4 Phosphorylation in T Lymphocytes, J. Immunol, Feb 15; 164(4):1768-74. 403. Kanik S., Chrousos G.P., Schumacher H. R, Crane M L., Yarboro C H., Wilder R L., (2000), ACTH, 37

George P. Chrousos, M.D. Glucocorticoid and Androgen Secretion in Patients with New Onset Synovitis/Rheumatoid Arthritis: Relations with Indices of Inflammation, J. Clinical Endocrinol. Metab. 85: 1461-1466 404. Vgontzas, A.N., Papanicolaou, D. A., Bixler, E. O., Hopper, K., Lotsikas, A., Kales, A., Chrousos G.P. (2000), Sleep Apnea and Daytime Sleepiness and Fatigue: Relations With Visceral Obesity, Insulin Resistance, and Hypercytokinemia, J. Clin. Endocrinol. Metab., 85:1151-1158. 405. Pathomvanich, A., Merke, D.P., Chrousos G.P., (2000) Early Puberty: A Cautionary Tale (Commentary); Pediatrics, 105:115-116. 406. Torpy D.J., Papanicolaou D.A., Lotsikas A. J., Wilder R.L., Chrousos, G.P., Pillemer S.R., (2000) Responses of the Sympathetic Nervous System and the Hypothalamic-Putuitary-Adrenal Axis to Interleukin-6 in fibromyalgia, Arthritis & Rheumatism ; 43 (4): 872-880. 407. Deuster P.A., Petrides J.S., Singh A., Chrousos G.P., Poth M.L., (2000) Endocrine Response to High- Intensity Exercise: Dose-Dependent Effects of Dexamethasone, J. of Clinical Endocrinology and Metab., 85:1066-1073. 408. Hsin L-W, Webster E.L., Chrousos G.P., Gold P.W., Eckelman W.C., Contoreggi C., Rice K.C., (2000) Synthesis and Biological Activity of Fluoro-Substituted Pyrrolo [2,3-d]pyrimidines: the Development of Potential Positron Emission Tomography Imaging Agents for Corticotropin- Releasing Hormone type 1 Receptor, Bioorganic & Medicinal Chemistry Letters 10:707-710. 409. Kanik K.S., Chrousos G.P., Schumacher H.R., Crane M.L., Yarboro C.H., Wilder R.L., (2000) Adrenocorticotrophin, Glucocorticoid, and Androgen Secretion in Patients with New Onset Synovitis/Rheumatoid Arthritis: Relations with Indices of Inflammation, J. of Clinical Endocrinology and Metab., 85:1461-1466. 410. Bornstein, S.R., Asab, M. A., Glasow, A., Path, G., Hauner, H., Tsokos, M., Chrousos G.P., Scherbaum, W. A., (2000) Immunohistochemical and Ultrastructural Localization of Leptin and Leptin Receptor in Human White Adipose Tissue and Differentiating Human Adipose Cells in Primary Culture, Diabetes, 49:532-538. 411. Willenberg, H.S., Bornstein, S.R., Hiroi, N., Path, G., Goretzki, P.E., Scherbaum, W.A., Chrousos G.P., (2000) Effects of a Novel Corticotropin-Releasing -Hormone Receptor Type I Antagonist on Human Adrenal Function, Molec. Psychiatry., 5:137-141. 412. Habib K.E., Weld K.P., Rice K.C., Pushkas J., Champoux M., Listwak S., Webster E.L., Atkinson A.,Schulkin J., Contoreggi C., Chrousos G.P., McCann S.M., Suomi S.J., Higley J.D., Gold P.W (2000) Oral Administration of a CRH Receptor Antagonist Significantly Attenuates Behavioral, Neuroendocrine, and Autonomic Responses to Stress in Primates, Proc. Ntl. Acad. Sci. USA., 10:1073-1079. 413. Berga, S.L., Loucks-Daniels, T.L., Adler, L.J., Chrousos, G.P., Cameron, J.L., Matthews, K.A., Marcus, M.D. (2000) Cerebrospinal Fluid Levels of Corticotropin-Releasing Hormone in Women with Functional Hypothalamic Amenorrhea, Am J Obstet Gynecol, 182:776-784. 414. Hsin L-W, Webster E.L., Chrousos G.P., Gold P.W., Eckelman W.C., Contoreggi C., Rice K.C., (2000) Synthesis of [3H] LWH-154: a Potent Radioligand for Corticotropin-Releasing Hormone Type 1 Receptor, J. Labeled Compounds and Pharmaceuticals, 43:899-908. 415. Bornstein, S.R., Wolkersdorfer, G.W., Preas, H.L., Chrousos G.P., Suffredini, A.F., (2000) Brief Report: Plasma Dehydroepiandrosterone (DHEA) Levels During Acute Experimental Endotoxemia and Antiinflammatory Therapy in Humans, Critical Care Med, 28(6):2103-2106. 38

George P. Chrousos, M.D. 416. Nawab, S.S., Miller, C.S., Dale, J.K., Greenberg, B.D., Friedman, T.C., Chrousos, G.P., Straus, S.E.,Rosenthal, N.E. (2000) Self-reported sensitivity to chemical exposures in five clinical populations and healthy controls. Psychiatry Research 95:67-74. 417. Doppman, J.L., Chrousos, G.P., Papanicolaou, D.A., Stratakis, C.A., Alexander, H.R., Nieman, L.K. (2000) Adrenocorticotropin-independent Macronodular Adrenal Hyperplasia: An Uncommon Cause of Primary Adrenal Hypercortisolism. Radiology, 216(3):797-802. 418. Bottner, A., Haidan, A., Eisenhofer, G., Kristensen, K., Castle, A.L., Scherbaum, W.A., Schneider, H., Chrousos, G.P., Bornstein, S.R. (2000) Increased Body Fat mass and Suppression of Circulating Leptin Levels in Response to Hypersecretion of Epinephrine in Phenylethanolamine-N-Methyltransferase (PNMT)-Overexpressing Mice. Endocrinology, 141(11):4239-4246. 419. Merke, D.P., Chrousos, G.P., Eisenhofer, G., Weise, M., Keil, M.F., Rogol, A.D., Van Wyk, J.J., Bornstein, S.R. (2000) Adrenomedullary Dysplasia and Hypofunction in Patients with Classic 21- Hydroxylase Deficiency. N Engl J Med. 343(19):1362-1368. 420. Huang, S.C., Koch, C.A., Vortmeyer, A.O., Pack, S.D., Lichtenauer, U.D., Mannan, P., Lubensky, I.A., Chrousos, G.P., Gagel, R.F., Pacak, K., Zhuang, Z. (2000) Duplication of the Mutant RET Allele in Trisomy 10 or Loss of the Wild-Type Allele in Multiple Endocrine Neoplasia Type 2-associated Pheochromocytomas. Cancer Research. 60:6223-6226. 421. Franchimont, E., Bouma, G., Galon, J., Wolkersdorfer, G.W., Haidan, A., Chrousos, G.P, Bornstein, S.R.(2000) Adrenal Cortical Activation in Murine Colitis. Gastroenterology, 119:1560-1568. 422. Bornstein, S.R., Tian, H, Haidan, A., Bottner, A., Hiroi, N., Eisenhofer, G., McCann, S.M., Chrousos,.P., Roffler-Tarlov, S. (2000) Deletion of Tyrosine Hydroxylase Gene Reveals Functional Interdependence of Adrenocortical and Chromaffin Cell System in Vivo., PNAS, 97:14742-14747. 423. Longui, C.A., Vottero, A., Adamson, P.C., Cole, D.E., Kino, T., Monte, O., Chrousos, G.P. (2000) Low Glucocorticoid Receptor Alpha/beta Ratio in T-cell Lymphoblastic Leukemia. Horm. Metab. Res., 32:401- 406. 424. Garcia-Borreguero, D., Wehr, T.A., Larrosa, O., Granizo, J.J., Hardwick, D., Chrousos, G.P., and Friedman, T.C (2000) Glucocorticoid Replacement is Permissive for Rapid Eye Movement Sleep and Sleep Consolidation in Patients with Adrenal Insufficiency. J. Clin. Endocrinol. Metab. 85:4201-4206. 425. Hope, P.J., Tumbull, H., Farr, S., Morley, J.E., Rice, K.C., Chrousos, G.P., Torpy, D.J., Wittert, G.H. (2000) Peripheral Administration of CRF and Urocortin: Effects on Food Intake and the HPA axis in the Marsupial Sminthopsis crassicaudata. Peptides, 21:669-677. 426. Mitsiades, N., Poulaki, V., Tseleni-Balafouta, S., Chrousos, G.P., Koutras, D.A. (2000) Fas Ligand Expression in Thyroid Follicular Cells from Patients with Thionamide-treated Graves’ Disease. Thyroid, 10:527-532. 427. Hauk PJ, Hamid QA, Chrousos GP, Leung DY (2000) Induction of Corticosteroid Insensitivity by Microbial Superantigens. J All Clin Immunol 105: 782-787 428. Merke, D.P., Cho, D., Calis, K.A., Keil, M.F., Chrousos, G.P. (2001) Hydrocortisone Suspension and Hydrocortisone Tablets Are not Bioequivalent in the Treatment of Children with Congenital Adrenal Hyperplasia.J. Clin. Endocrinol. Metab., 86: 441-445. 429. Tian X., Hsin L-W., Webster E. L., Contoreggi C., Chrousos G P., Gold P. W., Habib K., Ayala A., Eckelman W.C., Jacobson, A.E. Rice K.C.(2001) The Development of a Potential Single Photon Emission 39

George P. Chrousos, M.D. Computed Tomography (SPECT) Imaging Agent for the Corticotropin-releasing Hormone Receptor Type 1. Bioorganic & Medicinal Chemistry Letters, 11: 331-333 430. Vgontzas, A.N., Bixler, E.O, Wittman, A.M., Zachman, K., Lin, H.M., Vela-Bueno, A., Kales, A., Chrousos, G.P.(2001)Middle-Aged Men Show Higher Sensitivity of Their Sleep to the Arousing Effects of Corticotropin-releasing Hormone than Younger Men: Clinical Implications., J. Clin. Endocrinol. Metab. 86: 431. Vgontzas, A.N., Legro, R.S., Bixler, E.O., Grayev, A., Kales, A., Chrousos, G.P. (2001) Polycystic Ovary Syndrome is Associated with Obstructive Sleep Apnea and Daytime Sleepiness: Role of Insulin Resistance.J. Clin. Endocrinol. Metab.86: 517-520. 432. Strickland I., Kisich K., Hauk P.J., Vottero A., Chrousos G.P., Klemm D.J., Leung D.Y.M. (2001) High Constitutive Glucocorticoid Receptor Beta in Human Neutrophils Enables Them to Reduce Their Spontaneous Rate of Cell Death in Response to Corticosteroids. J. Exp. Med.193: 585-593 433. Path, G., , S.R., Gurniak, M., Chrousos, G.P., Scherbaum, W.A., Hauner, H. (2001) Human Breast Adipocytes Express Interleukin (IL)-6 and its Receptor System: Increased IL-6 Production by beta- Adrenergic Activation and Effects of IL-6 on Adipocyte Function. J Clin Endocrinol. Metab.86: 2281- 2288 434. Erickson K., Thorsen P., Chrousos G., Grigoriadis D.E., Khongsaly O., McGregor J., Schulkin J. (2001) Preterm Birth: Associated Neuroendocrine, Medical, and Behavioral Risk Factors. J. Clin. Endocrinol. Metab.86: 2544-2552 435. Hiroi, N., Chrousos, G.P., Abu-Asab, M., Bonat, S., Lafferty, A., White, A., Bornstein, S.R. (2001) Adrenocortical-Pituitary Hybrid Tumor Causing Cushing’s Syndrome. J. Clin. Endocrinol. Metab.86: 2631-2637 436. Cizza, G., Dorn, L.D., Lotsikas, A., Sereika, S., Rotenstein, D., Chrousos, G.P. (2001) Circulating Plasma Leptin and IGF-1 Levels in Girls with Premature Adrenarche: Potential Implications of a Preliminary Study. Hormone and Metabolic Research 33:148-143 437. Kraft M., Hamid O., Chrousos G., Martin R.J., Leung D. (2001) Decreased Steroid Responsiveness at Night: Is the Macrophage Responsible? Am. J. Resp. Crit. Care Med. 163: 1219-1225 438. Poulaki, V., Mitsiades, N., Mastorakos, G., Caspi, R.R., Chrousos, G.P., and Bouzas, E. (2001) Fas/Fas ligand-associated Apoptosis in Experimental Autoimmune Uveoretinitis in Rodents: Role of Proinflammatory Corticotropin-releasing Hormone. Exp. Eye Res.72:623-629 439. Schneider, R., Bornstein, S.R., Chrousos, G.P., Boxberger, S., Ehniger, G., Breidert, M. (2001) Leptin mediates a proliferative response in human gastric mucosa cells with functional receptor. Horm Metab Res. 33(1):1-6. 440. Bernardini, R., Johnson, E.O., Kamilaris, T., Chiarenza, A., Cantarella, G., Calogero, A.E., Lempereur , L., Chrousos, G.P., Giuffrida, R., Gold, P.W. (2001) Increased ACTH and cortisol secretion after interleukin- alpha injection in the common marmoset (Callithrix jacchus jacchus). Life Sci. 68(14):1657- 65. 441. Baker, D. G., Ekhator, N. N., Kasckow, J. W., Hill, K. K., Zoumakis, E., Dashevsky, B. A., Chrousos, G. P., and Geracioti, T. D.(2001) Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorder. Neuroimmunomodulation. 9(4), 209-217. 442. Kuperman H., Damiani D., Chrousos G.P., Dichtchenian V., Chrousos G.P., Della Manna T., Filho V. O., Setian N. (2001) Evaluation of the Hypothalamic-pituitary-adrenal Axis in Children with Leukemia before 40

George P. Chrousos, M.D. and after 7 Weeks of High Dose Glucocorticoid Therapy. J. Clin. Endocrinol. Metab. 86: 2993-2996 443. Kraft M. Hamid Q. Chrousos G.P., Martin RJ, Leung DY. (2001) Decreased steroid responsiveness at night in nocturnal asthma. Is the macrophage responsible? Am J Respir Crit Care Med. 163: 1219-25. 444. Ghizzoni L. Barreca A, Mastorakos G. Furlini M., Vottero A. Ferrari B., Chrousos GP, Bernasconi S. (2001) Leptin inhibits steroid biosynthesis by human granulosa-lutein cells. Horm Metab Res. 33 : 323-8. 445. Vgontzas A., Bixler E.O., Lin H.-M., Prolo P., Mastorakos G., Vela-Bueno A., Kales A., Chrousos G.P.(2001) Chronic Insomnia is Associated with Nyctohemeral Activation of the Hypothalamic-pituitary- adrenal Axis. J. Clin. Endocrinol. Metab.86: 3787-3794 446. Hiroi N., Wong M.L., Licinio J., Park C., Gold P.W., Chrousos G.P., Bornstein S.R. (2001) Expression of Corticotropin Releasing Hormone Receptors Type 1 and Type 2 mRNA in Suicide Victims and Controls. Mol. Psychiatry 6: 540-546 447. Kohno M., Kawahito Y., Tsubouchi Y., Hashiramoto A., Yamada R., Inoue K., Kusaka Y., Kubo T., Elenkov I. J, Chrousos G.P., Kondo M., and Sano H. (2001) Urocortin Expression in Synovium of Patients with Rheumatoid Arthritis and Osteoarthritis: Relation to Inflammatory Activity. J. Clin. Endocrinol. Metab.86:4344-4352 448. Makrigiannakis A., Zoumakis E., Kalantaridou S., Coutifaris C., Coukos, G., Rice K., Gravanis, A. and Chrousos G. P. (2001) Corticotropin-releasing Hormone (CRH) Promotes Blastocyst Implantation and Early Maternal Tolerance. Nature Immunology 2:1018-24 449. Abad V., Chrousos G.P., Reynolds J., Nieman L., Hill S., Weinstein R., Leong G.(2001) Glucocorticoid Excess during Adolescence Leads to a Major, Persistent Deficit in Bone Mass and Increase in Central Body Fat. J. Bone and Min. Research. 16; 1879-85 450. Elenkov I. J., Wilder R. L., Bakalov V. K., Link A.A., Dimitrov M., Fisher S., Crane M., Kanik K., Chrousos G. P. (2001) Interleukin 12, Tumor Necrosis Factor-alpha and Hormonal Changes during Late Pregnancy and Early Postpartum: Implications for Autoimmune Disease Activity during These Times. J. Clin. Endocrinol. Metab. 86: 4933-8 451. Kino T., Stauber R.H., Resau J. H., Pavlakis, G., Chrousos G. P. (2001) Pathologic Human Glucocorticoid Receptor (GR) Mutant Has a Transdominant Negative Effect on the Wild Type GR by Inhibiting Its Translocation into the Nucleus: Importance of the Ligand-binding Domain for Intracellular GR Trafficking. J. Clin. Endocrinol. Metab. 86: 5600-8 452. Koch, C.A., Vortmeyer, A.O., Huang, S.C., Moley, J.F., Azumi, N., Chrousos, G.P., Gagel, R.F., Zhuang, S., Pacak, K. (2001) Allelic imbalance of the mutant and wild-type RET allele in MEN 2A-associated medullary thyroid carcinoma. Oncogene 20:7809-11 453. Maurer M, Trajanoski Z, Hiroi N, Frey G, Galom J, Willenberg HS Gold PW, Chrousos GP, Scherbaum WA, Bornstein SR (2001) Differential gene expression profile of glucocorticoids, testosterone and dehydroepiandrosterone in human cells. Hormone Metab. Res. 33:691-695 454. Galon J., Franchimont D., Hiroi N., Boettner A., Ehrhart-Bornstein M., Chrousos G.P., Bornstein S.(2002) Gene Profiling Reveals Unknown Enhancing and Suppressive Actions of Glucocorticoids on Immune Cells. FASEB J.16: 61-71 455. Kino T., Slobodskaya O., Pavlakis, N. and Chrousos G. P. (2002) Nuclear Receptor Coactivator p160 Proteins Enhance the Human Immunodeficiency Virus (HIV) Type 1 Long Terminal Repeat Promoter by Bridging Promoter Bound Factors and the Tat/pTEF Complex. J. Biol. Chem., on-line release 11/01/01 41

George P. Chrousos, M.D. 277(4):2396-405. 456. Hsin L-W., Tian X., Webster E.L., Coop A., Caldwell T. C., Jacobson A.E., Chrousos G.P., Gold P.W., Habib, K.H., Ayala A., Eckelman W.C., Contoreggi C., Rice. K. (2002) CRHR1 Receptor Binding and Lipophilicity of Pyrrolopyrimidines, Potential Nonpeptide Corticotropin-releasing Hormone Type 1 Receptor Antagonists. Biorg. Med. Chem. 10:175-183 457. Koch CA, Huang SC, Zhuang Z, Stolle C., Azumi N, Chrousos GP, Vortmeyer AO, Pacak K (2002) Somatic VHL Gene Deletion and Point Mutation in MEN 2A-associated Pheochromocytoma. Oncogene 21:479-482 458. Franchimont, D., Galon, J., Vacchio, M.S., Fan, S., Visconti, R., Frucht, D.M., Geenen, V., Chrousos, G.P., Ashwell, J.D., O’Shea, J.J. (2002) Positive Effects of Glucocorticoids on T Cell Development and Function by Upregulation of Interleukin-7 Receptor (. J. Immunol,.168: 2212-2218 459. Koch C A, Vorrtmeyer A O, Diallo R, Poremba C, Giordano T J, Sanders D, Bornstein S R, Chrousos G P, and Pacak K. (2002) Survivin: A Novel Neuroendocrine Marker for Pheochromocytoma. Eur. J. Endocrinol 146: 381-388 460. Mendonca B B, Leite M V, deCastro M, Kino T, Elias L L, Bachega T A S, Billerbeck A E Arnhold I A J P, Chrousos G P, Latronico A C (2002) Female Pseudohermaphrodotism Caused by A Novel Homozygous Missence Mutation of the Glucocorticoid Receptor Gene. J. Clin. Endocrinol.. Metab. 87:1805-1809 461. Meduri G. U., Tolley E. A., Chrousos G. P. and Stentz F. (2002) Prolonged Methylprednisolone Treatment Suppresses Systemic Inflammation in Patients with Unresolving ARDS: Evidence for Inadequate Endogenous Glucocorticoid Secretion and Inflammation-induced Immune Cell Resistance to Glucocorticoids. Am. J. Resp. Crit. Care Med. 165:983-991 462. Sato H., Nagashima Y., Chrousos GP, Ichihashi M., Fusanaka Y. ( 2002) The Expression of Corticotropin- releasing Hormone in Melanoma. Pigment Cell Res. 15:98-103 463. Charmandari E, Weise M, Bornstein S R, Eisenhofer G, Keil M F, Chrousos G, Merke D P. (2002) Children with Classic Congenital Adrenal Hyperplasia Have Elevated Serum Leptin Concentrations and Insulin Resistance.J. Clin. Endocrinol. Metab. 87: 2139-2143 464. Alesci S, Ramsey WJ, Bornstein SR, Chrousos GP, Hornsby PJ, Benvega S, Trimarchi F, Ehrhart- Bornstein M (2002) Adenoviral Vectors Can Impair Adrenocortical Steroidogenesis: Clinical Implications for Natural Infections and Gene Therapy. Proc. Natl Acad. Sci. USA 99:7484-7489 465. Vottero A., Kino T., Combe H., Lecomte P., and Chrousos G.P. (2002) A Novel, C-terminal Dominant Negative Mutation of the Glucocorticoid Receptor Causes Familial Glucocorticoid Resistance through Abnormal Interactions with p160 Steroid Receptor Coactivators. J. Clin. Endocrinol. Metab. 87: 2658-2667 466. Greiner E., Atkinson A. J., Ayala A., Chrousos G. P., Contoreggi C., Eckelman W. C., Gold P.W., Habib K., Jacobson A.E., Webster E.,L., Rice K.C. (2002) Synthesis of Doubly Labelled 13C Antalarmin Isotopomers for Pharmakokinetic Studies. J. Lab. Cpds and Radiopharmaceuticals 45:637-645 467. Charmandari E, Eisenhofer G, Mehlinger S, Carlson A, Wesley R, Keil M, Chrousos GP, New MI, Merke DP. (2002) Adrenomedullary Function May Predict Phenotype and Genotype in Classic 21-Hydroxylase Deficiency. J Clin Endocrinol Metab. 87: 3031-3037 468. Young IR, Chan EC, Smith R, Chrousos GP, Veldhuis JD, Canny BJ (2002) The Effect of Antalarmin, a Novel Corticotropin Releasing Hormone Antagonist on the Dynamic Function of the Preterm Ovine Fetal Hypothalamic-pituitary-adrenal axis. Neuroendocrinology 76:47-54 42

George P. Chrousos, M.D. 469. Webster E L, Barrientos R M, Contoreggi C, Isaac M G, Ligier S, Habib K, Chrousos G P, McCarthy E F, Rice K C, Gold PW, Sternberg E M. (2002) Corticotropin-releasing Hormone (CRH) Antagonist Attenuattes Adjuvant-induced Arthritis: Evidence Supporting Major Role for CRH in Peripheral Inflammation. J. Rheumatol. 29: 1252-1261. 470. Gabry K.E., Chrousos G.P., Rice K.C., Mostafa R.M., Sternberg E., Negrao A.B., Webster E.L., McCann S.M., Gold P.W. (2002) Marked suppression of gastric ulcerogenesis and intestinal responses to stress by a novel class of drugs. Molec. Psych. 7:474-483. 471. Vgontzas A N, Zoumakis M, Papanicolaou D A, Bixler E , Prolo P, Lin H-M, Vela-Bueno A, Kales M d, and Chrousos GP. (2002) Chronic Insomnia is Associated with a Shift of IL-6 and TNF Secretion from Nighttme to Daytime. Metabolism, 29:1252-1261 472. Koch CA, Mauro D, Walther MM, Linehan,WM, Vortmeyer AO, Jaffe R, Pacak K, Chrousos GP, Zhuang Z, Lubensky IA (2002) Pheochromocytoma in VHL Disease: Distinct Histopathologic Phenotype Compared to Pheochromocytoma in Multiple Endocrine Neoplasia Type 2. Endocrine Pathology 13:17-27 473. Mansky P. J., Liewehr D. J., Steinberg S. M., Chrousos G. P., Avila N. A., Long L., Bernstein D., Mackall C. L., Hawkins D. S., and Helman L. J. (2002) Treatment of Metastatic Osteosarcoma with the Somatostatin Analog OncoLar: Significant Reduction of IGF-1 Serum Levels. J. Ped. Hematol. Oncol. 24:440-446 474. Pacak K, Tjurmina O, Palkovits M, Goldstein DS, Koch CA, Hoff T., Chrousos GP (2002) Chronic Hypercortisolemia Inhibits Dopaminergic Activity in the Nucleus Accumbens but not the Prefrontal Cortex: An in Vivo Microdialysis Study. Neuroendocrinology 76:148-157 475. Kino T, Gragerov A, Slobodskaya O, Tsopanomihalu-Nglotsou M, Chrousos GP, and Pavlakis G (2002) Human Immunodeficiency Virus Type 1 (HIV-1) Accessory Protein Vpr Induces Transcription of the HIV- 1 and Glucocorticoid-responsive Promoters by Binding Directly to p300/CBP Coactivators. J. Virol. 76:9724-9734 476. Kino T. Tsukamoto M., and Chrousos GP (2002) Transcription Factor TFIIH Components Enhance the GR Coactivator Activity but Not the Cell Cycle –arresting Activity of the Human Immunodeficiency Virus Type-1 Protein Vpr. Bioch. Biophys. Res. Commun. 298: 17-23 477. Mirani M, Elenkov I, Volpi S, Hiroi N, Chrousos GP, and Kino T (2002) Human Immunodeficiency Type- 1 (HIV-1) Protein Vpr Suppresses Interleukin-12 Production from Human Monocytes by Enhancing Glucocorticoid Action: Potential Implications of Vpr Coactivator Activity for the Innate and Cellular Immunity Deficits Observed in HIV-1 Infection. J Immunol 169:6361-6368 478. Skalkidou A, Petridou E, Papathoma E, Salvanos H, Chrousos GP, Trichopoulos D (2002) Birth Size and Neonatal Levels of Major Components of the IGF System: Implication for Later Risk of Cancer. J Ped Endocrinol Metab. 15: 1479-1486 479. Bader T, Zoumakis E, Friedberg M, Hiroi N, Chrousos GP, Hochberg Z (2002) Human Adipose Tissue under in Vitro Inhibition of 11beta-Hydroxysteroid Dehydrogenase Type 1: Differentiation and Metabolism Changes. Horm Metab Res 34: 752-757 480. Wolkersdorfer GW, Bornstein SR, Higginbotham JN, Hiroi N, Vaquero JJ, Green MV, Blaese RM, Aguilera G, Chrousos GP, Bornstein SR (2002) A Novel Approach Using Transcomplementing Adenoviral Vectors for Gene Therapy of Adrenocortical Cancer. Horm Metabol Res 34: 279-287 481. Kino T and Chrousos GP (2003) Tumor Necrosis Factor–alpha- and Fas-associated FLASH Inhibits 43

George P. Chrousos, M.D. Transcriptional Acivity of the Glucocorticoid Receptor by Binding to and Interfering with its Interaction with p160 Type Nuclear Receptor Coactivators. J Biol Chem 278: 3023-3029 482. Petridou E, Mantzoros C, Dessypris N, Koukoulomatis P, Addy C, Voulgaris Z, Chrousos G, Trichopoulos D (2003) Plasma Adiponectin Concentrations in Relation to Endometrial Cancer: A Case Control Study in Greece. J Clin Endocrinol Metab 88: 983-997 483. Tiosano D, Eisenstadt I, Militianu D, Chrousos GP , Hochberg Z (2003) 11-Beta- Hydroxysteroid Dehydrogenase Activity in Hypothalamic Obesity. J Clin Endocrinol Metab 88: 379-384 484. Friedberg M, Zoumakis E, Hiroi N, Bader T, Chrousos GP, Hochberg Z (2003) Modulation of 11-Beta- Hydroxysteroid Dehydrogenase Type 1 in Mature Human Subcutaneous Adipocytes by Hypothalamic Messengers. J Clin Endocrinol Metab 88: 385- 393 485. Marini JC, Hopkins E, Glorieux FH, Chrousos GP, Reynolds JC, Gundberg CM, Reing CM (2003) Positive Linear Growth and Bone Responses to Growth Hormone Treatment in Children with Types III and IV Osteogenesis Imperfecta: High Predicitive Value of the Carboxyterminal Propeptide of Type I Procollagen. J Bone Miner Res 18: 237-243 486. Vottero A, Kimci-Sarfaty C, Kratzsch J, Chrousos GP, Hochberg Z. (2003) Transcriptional and Translational Regulation of the Splicing Isoforms of the Growth Hormone Receptor by Glucocorticoids. Horm Metab. Res. 35: 7-12 487. Vottero A, Kimcy-Sarfaty C, Kratzsch J, Miller G, Lafferty A, Chrousos GP, Hochberg Z. (2003) Relative Abudance of Growth Hormone Receptor Isoforms in Rhesus Monkey Tissues and Human Transformed Lymphocytes. Horm. Metab. Res. 35: 1-6 488. Merke DP, Fields JD, Keil MF, Vaituzis C, Chrousos GP, Giedd JN (2003) Children with Classic Congenital Adrenal Hyperplasia Have Decreased Amygdala Volume: Potential Prenatal and Postnatal Hormonal Effects. J. Clin. Endocrinol. Metab 88: 1760-1765 489. Vgontzas AN, Zoumakis M, Bixler EO, Lin H-M, Prolo P, Vela-Bueno A, Kales A and Chrousos GP (2003) Impaired Nighttime Sleep Is Associated with Elevated Plasma IL-6 and Cortisol Levels in Healthy Old vs. Young Adults: Physiologic and Therapeutic Implications. J Clin Endocrinol Metab 88: 2087-2095 490. Kino T, Souvatzoglou E, De Martino MU, Tsopanomihalou M, Wan Y. and Chrousos GP (2003) Protein 14-3-3 sigma Interacts with and Favors Cytoplasmic Subcellular Localization of the Glucocorticoid Receptor, Acting as a Negative Regulator of the Glucocorticoid Signaling Pathway. J. Biol. Chem. 252:32- 44 491. Alesci S, De Martino M, Mirani M, Benvega S, Trimarchi F, Kino T, and Chrousos GP (2003) L- Carnitine: A Nutritional Modulator of Glucocorticoid Receptor Functions. FASEB J. (Electronic release June 17). 17(11):1553-5 492. Vozarova B, Weyer C, Snitker S, Gautier J-F, Cizza G, Chrousos G, Ravussin E, and Tataranni PA (2003) Effect of Cortisol on Muscle Sympathetic Nerve Activity in Pima Indians and Caucasians. J Clin Endocrinol. Metab 88: 3218-26 493. Jagoda, E., Contoreggi, C Lee MJ, Kao CHK , Szajak LP , Listwak, Gold PW, Chrousos GP, Greiner E,. Jacobson AE, Rice KC and Eckelman W (2003) Autoradiographic Visualization of Corticotropin Releasing Hormone Type 1 Receptors with a Nonpeptide Ligand: Synthesis of [ MJL-1-101-2. J Med Chem. 46:3559-3562 494. Hiroi N, Kino T, Bassett M, Rainey WE, Phung M, Abu-Asab M, Fojo T, Briata P, Chrousos GP, Bornstein 44

George P. Chrousos, M.D. SR. (2003) Pituitary Homeobox Factor 1, A Novel Transcription Factor in the Adrenal Regulating Steroid 11Beta -hydroxylase. Horm Metab Res. 35: 273-8. 495. Skalkidou A, Petridou E., Papathoma E, Salvanos H, Kedikoglou S., Chrousos G. and Trichopoulos D (2003) Determinants and Consequences of Major Insulin-like Growth Factor Components among Full-term Neonates. Canc Epidemiol Biomark Prev 12:860-865. 496. Contoreggi C, Herning R.I, Na P, Gold PW, Chrousos GP, Negro PJ, Better W, and. Cadet JL (2003) Stress Hormone Responses to Corticotropin–Releasing Hormone (CRH) in Substance Abusers without Severe Co-morbid Psychiatric Disease. Biol Psychiatry 54: 873-878. 497. De Martino M, Bhattachryya N, Alesci S, Fabbri A, Chrousos GP and Kino T (2004)The Glucocorticoid Receptor (GR) and the Orphan Nuclear Receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) Interact with and Mutually Affect Each Other’s Transcriptional Activities: Implications for Intermediary Metabolism. Molecular Endocrinol. 18:820-833. 498. Kanaka-Gantenbein C, Kitsiou S, Mavrou A, Stamoyannou L, Kolialexi A, Kekou K, Liakopoulou M, Chrousos G (2004) Tall Stature, Insulin Resistance, and Disturbed Behavior in a Girl with the Triple X Syndrome Harboring 3 SHOX Genes: Offspring of a Father with Mosaic Klinefelter Syndrome but with Two Maternal X Chromosomes. Horm Res 61: 205-210. 499. Weise M, Mehlinger S, Rawson E, Charmandari E, Eisenhoffer G, Yanovski J, Chrousos GP, Merke D. (2004) Patients with Classic Congenital Adrenal Hyperplasia Have Decreased Epinephrine Reserve and Defective Glucose Elevation in Response to High Intensity Exercise, J. Clin. Endocrinol. Metab. 89: 591- 597. 500. Mantzoros C, Petridou E, Dessypris N, Chavelas H, Dalamaga M, Alexe DM, Papadiamantis Y, Markopoulos C, Spanos E, Chrousos G, Trichopoulos D (2004) Adiponectin and Breast Cancer Risk J Clin Endocrinol Metab 89: 1102-7. 501. Ward AM, Syddall HE, Wood PJ, Chrousos GP, Phillips DI (2004) Fetal Programming of the Hypothalamic-pituitary-adrenal (HPA) Axis: Low Birth Weight and Central HPA Regulation. J Clin Endocrinol Metab 89: 1227-33. 502. Charmandari E, Kino T, Souvatzoglou E, Vottero A, Bhattacharayya N, and Chrousos GP (2004) Natural Glucocorticoid Receptor Mutants Causing Glucocorticoid Resistance: Molecular Genotype, Genetic Transmission and Clinical Phenotype. J. Clin. Endocrinol. Metab.89: 1939-1949. 503. Charmandari E, Merke D, Negro PJ, Keil M, , Martinez PE, Haim A, Gold PW and Chrousos GP (2004) Endocrinologic and Psychologic Evaluation of 21-Hydroxylase Deficiency Carriers and Matched Normal Subjects: Evidence for Physical and/or Psychologic Vulnerability to Stress , J Clin Endocrinol Metab 89:2228-2236. 504. Vgontzas A, Zoumakis E, Bixler EO, Lin H-M, Follett H, Kales A and Chrousos GP (2004) Adverse Effects of Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines. J Clin Endocrinol Metab 89: 2119-2126. 505. Yuhas Y, Weizman A, Chrousos GP, Ovadia H, Ashkenazi S. (2004) Involvement of the Neuropeptide Corticotropin-releasing Hormone in an Animal Model of Shigella-related Seizures. J Neuroimmunol. 153: 36-39. 45

George P. Chrousos, M.D. 506. Weise M, Drinkard B Mehlinger SL, Eisenhofer G, Chrousos GP and Merke DP (2004) Stress Dose of Hydrocortisone is not Beneficial in Patients with Classic Congenital Adrenal Hyperplasia Undergoing Short-term High-intensity Exercise. J. Clin. Endocrinol. Metab. 89: 3679-3684. 507. Kalantaridou SN, Naka KK, Papanikolaou E, Kazakos N, Kravariti M, Calis KA, Paraskevaidis EA, Sideris DA, Tsatsoulis A, Chrousos GP, and Michalis LK (2004) Impaired Endothelial Function in Young Women with Premature Ovarian Failure: Normalization with Hormone Therapy .J Clin Endocrinol Metab 89: 3907-3913. 508. Schulpis KH, Papassotiriou I, Vounatsou M, Karikas GA, Tsakiris S, Chrousos GP. (2004) Morning Preprandial Plasma Ghrelin and Catecholamine Concentrations in Patients with Phenylketonuria and Normal Controls: Evidence for Catecholamine-mediated Ghrelin Regulation. J Clin Endocrinol Metab 89:3983-7. 509. Vgontzas AN, Zoumakis E, Lin H-M, Bixler EO, Chrousos GP (2004) Marked Decrease of Sleepiness in Patients with Sleep Apnea by Etanercept, a TNF alphaAntagonist. J. Clin. Endocrinol. Metab. 89: 4409-13. 510. Charmandari E, Chrousos GP, Ichijo T, Bhattacharyya N, Vottero A, Souvatzoglou E, Kino T.Related Articles, Links (2005) The Human Glucocorticoid Receptor (hGR) {beta} Isoform Suppresses the Transcriptional Activity of hGR{alpha} by Interfering with Formation of Active Coactivator Complexes. Mol Endocrinol. 19: 52-64. 511. Glass JM, Lyden AK, Petzke F, Stein P, Whalen G, Ambrose K, Chrousos G, Clauw DJ. (2004) The effect of brief exercise cessation on pain, fatigue, and mood symptom development in healthy, fit individuals. J Psychosom Res. 57: 391-398. 512. Ayala AR, Pushkas J, Higley JD, Ronsaville D, Gold PW, Chrousos GP, Pacak K, Calis KA, Gerald M, Lindell S, Rice KC, Cizza C (2004) Behavioral, Adrenal and Sympathetic Responses to Long Term Administration of an Oral Corticotropin-releasing Hormone Receptor Antagonist in a Primate Stress Paradigm. J Clin Endocrinol Metab 89: 5729-5737. 513. Tiulpakov A, Rubtsov P, Dedov I, Peterkova V, Bezlepkina O, Chrousos GP, Hochberg Z J (2005) A Novel C-terminal Growth Hormone Receptor (GHR) Mutation Results in Impaired GHR-Stat5 but Normal Stat3 Signaling. J Clin Endocrinol Metab 90: 542-547. 514. Bloch M, Rubinow D, Schmidt PJ, Lotsikas A, Chrousos GP, Cizza G (2005) Cortisol Response to oCRH in a Model of Pregnancy and Parturition in Euthymic Women with and without a History of Postpartum Depression. J Clin Endocrinol Metab 90: 695-699. 515. Mantzoros C, Petridou E, Alexe DE, Skalkidou A, Dessypris N, Papathoma E, Salvanos H, Shetty E, Gavrila A, Kedikoglou S, Chrousos G, Trichopoulos, D (2004) Serum Adiponectin Concentrations in Relation to Maternal and Perinatal Characteristics in Newborns. Eur J Endocrinol 151:741-746. 516. Kino T, Ichijo T, Chrousos G (2004) FLASH Interacts with p160 Coactivator Subtypes and Differentially Suppresses Transcriptional Activity of Steroid Hormone Receptors. J Steroid Biochem and Molec Biol. 92: 357-363. 517. Kino T, Ichijo T, Charmandari E, De Martino M, Outas T and Chrousos GP (2005) The Human Immunodeficiency Virus Type-1 (HIV-1) Accessory Protein Vpr Inhibits the Effect of Insulin on the Foxo Subfamily of the Forkhead Transcription Factors by Interfering with its Binding to 14-3-3 Proteins: Potential Clinical Implications Regarding the Insulin Resistance of HIV-1-infected Patients. Diabetes 2005 Jan; 54(1): 23-31. 46

George P. Chrousos, M.D. 518. Lycopoulou L, Mamoulakis C, Hantzi E, Demetriadis D, Antypas S, Giannaki M, Bakoula C, Chrousos G, Papassotiriou I. (2005) Serum Amyloid A Protein Levels as a Possible Aid in the Diagnosis of Acute Appendicitis in Children. Clin Chem Lab Med. 43(1): 49-53. 519. Cizza G, Romagni P, Lotsikas A, Lam G, Rosenthal NE, Chrousos GP. (2005) Plasma leptin in men and women with seasonal affective disorder and in healthy matched controls. Horm Metab Res 37(1): 45-48. 520. Alesci S, Martinez P,Kelkar S, Ilias I, Ronsaville DS, Listwak SJ,.Ayala AR, Licinio J, Gold H, Kling MA, Chrousos GP, and Gold PW(2005) Major Depression Is Associated with Significant Diurnal elevations In Plasma IL-6 Levels, A Shift of Its Circadian Rhythm, and loss of physiologic complexity in its secretion: Clinical Implications. J Clin Endocrinol Metab 90:2522-2530. 521. Kino T, Gragerov A, Valentin A, Tsopanomihalou M, Ilyina-Gragerova G, Cohen-Erwin R, Chrousos GP and Pavlakis GN (2005) Vpr Protein of Human Immunodeficiency Virus Type 1 Binds to 14-3-3 Proteins and Facilitates Complex Formation with Cdc25C: Implications for Cell Cycle Arrest. J Virol 79:2780- 2787. 522. Petridou E, Mantzoros CS, Belechri M, Skalkidou A, Dessypris N, Papathoma E, Salvanos H, Lee JH, Kedikoglou S, Chrousos G, Trichopoulos D (2005). Neonatal leptin levels are strongly associated with female gender, birth length, IGF-I levels and formula feeding. Clin Endocrinol (Oxf).62(3):366-71. 523. Merke DP, Giedd JN, Keil MF, Mehlinger SL, Wiggs E, Holzer S, Rawson E, Vaituzis AC, Stratakis CA, Chrousos GP. (2005) Children Experience Cognitive Decline Despite Reversal of Brain Atrophy One Year Following Resolution of Cushing Syndrome. J Clin Endocrinol Metab. 90:2531-2536. 524. Fruchter O, Kino T, Zoumakis E, Alesci S, De Martino, M, Chrousos G, Hochberg, Z.(2005) The Human Glucocorticoid Receptor (GR) Isoform β Differentially Suppresses GRα-induced Transactivation Stimulated by Synthetic Glucocorticoids. J Clin Endocrinol Metab 90:3505-3509. 525. Charnandari E, Raji A, Kino T, Ichijo T, Tiulpakov A, Zachman K, Chrousos GP (2005) A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of C-terminus of hGR LBD in Conferring Transactivational Activity. J Clin Endocrinol Metab 90: 3696-3705. 526. Rubinow DR, Roca CA, Schmidt PJ, Danaceau MA, Putnam K, Cizza G, Chrousos G, Nieman L. (2005) Testosterone Suppression of CRH-Stimulated Cortisol in Men. Neuropsychopharmacology 30:1906-1912. 527. Margeli A, Skenderi K, Tsironi M, Hantzi E, Matalas AL, Vrettou C, Kanavakis E, Chrousos G, Papassotiriou I. Dramatic Elevations of Interleukin-6 and Acute Phase Reactants in Athletes Participating in the Ultradistance Foot Race "Spartathlon": Severe Inflammation and Lipid and Lipoprotein Changes in Protracted Exercise. J Clin Endocrinol Metab. 90: 3914-3918. 528. Putnam K, Chrousos GP, Nieman LK, Rubinow DR. (2005) Sex-Related Differences in Stimulated HPA Axis During Induced Gonadal Suppression. J Clin Endocrinol Metab. 90: 4224-4231. 529. Gold PW, Wong M-L, Goldstein D, Gold H, Ronsaville D, Esler M, Alesci S, Masood A, Licinio J, Geraciotti TD, Perini GI, DeBellis MD, Vgontzas AN, Charney DS, Chrousos GP, McCann SM and Kling MA (2005) Cardiac Implications of Increased Arterial Entry and Reversible 24-h Central and Peripheral Norepinephrine Levels in Melancholia. Proc Natl Acad of Sci USA.102: 8303-8308. 530. Deuster PA, Faraday MM, Chrousos GP, Poth MA (2005) Effects of Dehydroepiandrosterone and Alprazolam on Hypothalamic-Pituitary Responses to Exercise. J Clin Endocrinol Metab. 90:4777-4783. 531. Manoli I, Hanh Le H, Alesci S, McFann KK, Su Y, Kino T, Chrousos GP, and Blackman MR (2005) 47

George P. Chrousos, M.D. Monoamine Oxidase-A is a Major Target Gene for Glucocorticoids in Human Skeletal Muscle Cells: Induction of Gene and Oxidative Activity and Relevance to Glucocorticoid- Mediated Myopathy. FASEB J 19: 1359-1361. 532. Million M, Maillot C, Adelson DA, Nozu T, Gauthier A, Rivier J, Chrousos GP, Bayati A. Mattsson H, Tache Y. (2005) Peripheral injection of sauvagine prevents repeated colorectal distension-induced visceral pain in female rats. Peptides 26(7):1188-1195. 533. Kravariti M, Naka KK, Kalantaridou SN, Kazakos N, Katsouras CS, Makrigiannakis A, Paraskevaidis EA, Chrousos GP, Tsatsoulis A, Michalis LK. (2005) Predictors of Endothelial Dysfunction in Young Women with Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 90:5088-95. 534. Johnson EO, Kamilaris TC, Calogero AE, Gold PW, Chrousos GP. (2005) Experimentally-induced hyperthyroidism is associated with activation of the rat hypothalamic-pituitary-adrenal axis. Eur J Endocrinol. 153:177-185. 535. Nishikawa T, Suematsu S, Saito J, Soyama A, Ito H, Kino T, Chrousos G (2005).Human renal mesangial cells produce aldosterone in response to low-density lipoprotein (LDL).J Steroid Biochem Mol Biol. 96:309-316. 536. Chrousos GP, Ghaly L, Shedden, A,. Iezzoni D, and Harris AG (2005) Effects of Mometasone Furoate Dry Powder Inhaler and Beclomethasone Dipropionate Hydrofluroalkane and Chlorofluorocarbon on the Hypothalamic-pituitary-adrenal axis in Asthmatic Subjects. Chest 128:70-77. 537. Kino T, Ichijo T, Tiulpakov A Chheng L, Kozasa T and. Chrousos GP (2005) The GTP-binding (G) Protein β Interacts with the Activated Glucocorticoid Receptor and Suppresses Its Transcriptional Activity in the Nucleus. J Cell Biol 20;169(6):885-96. 538. Kakourou T, Kanaka-Gantenbein C, Papadopoulou A, Kaloumenou E, Chrousos GP (2005) Increased prevalence of chronic autoimmune (Hashimoto's) thyroiditis in children and adolescents with vitiligo. J Am Acad Dermatol. 2005 Aug; 53(2):220-3. 539. Kino T, Kozasa T and Chrousos GP (2005) Statin-induced Blockade of Prenylation Alters Nucleocytoplasmic Shuttling of GTP-binding Proteins γ2 and β2 and Enhances their Suppressive Effect on Glucocorticoid Receptor Transcriptional Activity. Eur J Clin Invest 35:508-513. 540. Schulpis KH, Papassotiriou I, Tsakiris S, Vounatsou M, and Chrousos GP (2005) Increased Plasma Adiponectin Concentrations in Poorly Controlled Patients with Phenyketonuria (PKU) Normalize with a Strict Diet: Evidence for Catecholamine-mediated Adiponectin Regulation and a Complex Effect of PKU Diet on Atherogenesis Risk Factors. Metabolism 54:1350-1355. 541. Siahanidou T, Mandyla H, Vounatsou M, Anagnostakis D, Papassotiriou I, and Chrousos GP (2005) Circulating Peptide YY Concentrations Are Higher in Preterm than Term Infants and Correlate Negatively with Body Weight and Positively with Serum Ghrelin Levels. Clin Chemistry. 51(11):2131-7. 542. Papoutsi Z, Kassi E, Tsiapara A, Fokialakis N, Chrousos GP, Moutsatsou P. (2005) Evaluation of Estrogenic/Antiestrogenic Activity of Ellagic Acid via the Estrogen Receptor Subtypes ERalpha and ERbeta. J Agric Food Chem. 53(20):7715-7720. 543. Papoutsi Z, Kassi E, Mitakou S, Aligiannis N, Chrousos GP, Moutsatsou P. (2006) Acteoside and Martynoside Exhibit Estrogenic/Antiestrogenic Activity. J Steroid Biochem and Mol Biol 98(1):63-71. Epub 2005 Sep 28. 544. Ichijo T, Voutetakis A, Cotrim AP, Bhattachryya N, Fujii M, Chrousos GP and Kino T (2005) The 48

George P. Chrousos, M.D. SMAD6/histone Deacetylase 3 Complex Silences the Transcriptional Activity of the Glucocorticoid Receptor: Potential Clinical Implications. J Biol Chem. 280(51):42067-77. 545. Nassis GP, Papantakou K, Skenderi K, Triandafillopoulou M, Kavouras S, Yannakoulia M, Chrousos G, Sidossis L. (2005) Aerobic Exercise Training Improves Insulin Sensitivity without Changes in Body Weight, Body Fat, Adiponectin and Inflammatory Markers in Overweight and Obese Girls. Metabolism 54(11): 1472-1479. 546. Papandreou O, Soldatou A, Tsitsika A, Cariyannis C, Papandreou T, Papassotiriou, Zachariadi A, and Chrousos GP (2005) Serum S100 Protein in Children with Acute Recurrent Headache: A Potentially Useful Marker for Migraine. Headache 45: 1313-1316. 547. Kino T, Liou S-H, Charmandari E and Chrousos GP (2005) Pathologic Human Glucocorticoid Receptor Mutants Demonstrate Defective Motility inside the Nucleus of Living Cells: Percent Recovery Time afterPhotobleaching (FRAP) is an Integrated Measure of Receptor Function. Mol Med. 10(7-12): 80-8. 548. Bamberger AM, Minas V, Kalantaridou S, Radde J, Sadeghian H, Loening T, Charalambopoulos J, Bruemmer J, Wagener C, Bamberger CM, Schulte HM, Chrousos GP and Makrigiannakis A (2005) Corticotropin-releasing Hormone Modulates Human Trophoblast Invasion through CEACAM-1 Regulation. Am J Pathol. 2006 68(1): 141-50. 549. Meduri GU, Muthiah MP, Carratu P, Eltorky M and Chrousos GP (2005) Nuclear factor-κB- and Glucocorticoid Receptor a- mediated Mechanisms in Regulation of Systemic and Pulmonary Inflammation during Sepsis and Acute Respiratory Distress Syndrome: Evidence for Inflammation–induced Target Tissue Resistance to Glucocorticoids. Neuroimmunomodulation 12(6): 321-38. 550. Nicolaidou P, Papadopoulou A, Georgouli H, Matsinos YG, Tsapra H, Fretzayas A, Giannoulia-Karantana A, Kitsiou S, Douros K, Papassotiriou I, Chrousos GP. (2006) Calcium and Vitamin D Metabolism in Hypocalcemic Vitamin D-Resistant Rickets Carriers. Horm Res. 65(2): 83-88. 551. Charmandari E, Kino T, Ichijo T, Zachman K, Alatsatianos A, Chrousos GP (2006) Functional Characterization of the Natural Human Glucocorticoid Receptor (GR) Mutants hGRalphaR477H and hGRalphaG679S Associated with Generalized Glucocorticoid Resistance. J Clin Endocrinol 91: 1535- 1543. 552. Ronsaville DS, Municchi G, Laney C, Cizza G, Meyer SE, Haim A, Radke-Yarrow M, Chrousos, GP, Gold PW, Martinez PE. (2006) Maternal and Environmental Factors Influence the Hypothalamic-pituitary- adrenal axis Response to Corticotropin-releasing Hormone Infusion in Offspring of Mothers with or without Mood Disorders. Develop Psychopathol 18(1): 173-94. 553. Alesci S, Manoli I, Su Y, Blackman M, Rennert O, Chrousos GP (2006) Development of a New Mitochondria-focused cDNA Microarray (hMitChip): Validation in Skeletal Muscle Cells and Implications for Pharmaco-and Mitogenomics. The Pharmacogenomics J. 6(5):333-42. 554. Kino T, Souvatzoglou E, Charmandari E, Ichijo T, Driggers P, Mayers C, Alatsatianos A, Manoli I, Westphal H, Chrousos GP and Segars JH (2006) Rho Family Guanine Nucleotide Exchange Factor Brx Couples Extracellular Signals to the Glucocorticoid Signaling System. J Biol Chem. 281: 9118-9126. 555. Krisnamoorthy S, Bei T, Zoumakis E, Chrousos GP and Iliadis AA (2006) Morphological and Binding Properties of Interleukin-6 on Thin ZnO Films Grown on (100) Silicon Substrates for Biosensor Applications. Biosens Bioelectron 22: 707-14. 556. Giedd JN, Clasen LS, Lenroot R, Greenstein D, Wallace GL, Ordaz S, Molloy EA, Blumenthal JD, Tossell JW, Stayer C, Samango-Sprouse CA, Shen D, Davatzikos C, Merke D, Chrousos GP (2006). Puberty- 49

George P. Chrousos, M.D. related influences on brain development. Mol Cell Endocrinol. 254-255:154-62. 557. Vgontzas AN, Trakada G, Bixler EO, Lin H-M, Pejovic S, Zoumakis E, Chrousos, GP, Legro R (2006) Plasma IL-6 and TNF-alpha Levels are Elevated in Polycystic Ovary Syndrome Independently of Obesity and Sleep Apnea. Metabolism 55: 1076-82. 558. Priftis K, Papadimitriou A, Anthracopoulos B, Gatsopoulou E, Fretzayas A, Nicolaidou P, Chrousos G (2006) Adrenal Function Improvement in Asthmatic Children on Inhaled Steroids Studied Longitudinally. Neuroimmunomodulation 13(1): 56-62. 559. Vgontzas AN, Pejovic, S, Zoumakis E, Lin H-M, Bixler EO, Basta M, Fang J, Sarrigiannidis A, Chrousos, GP (2007) Daytime Napping After a Night of Sleep Loss Decreases Sleepiness, Improves Performance, and Causes Beneficial Changes in Cortisol and Interleukin-6 Secretion. Am J Physiol Endocrinol Metab 292: E253-61. 560. Fruchter O, Zoumakis E, Alesci S, De Martino M, Chrousos G, Hochberg Z. (2006) Intracrine modulation of gene expression by intracellular generation of active glucocorticoids. Steroids. 71: 1001-6. 561. Leong GM, Abad V, Charmandari E, Reynolds JC, Hill S, Chrousos GP and Nieman LK (2007). The effects of child- and adolescent-onset endogenous Cushing syndrome on areal and volumetric bone mineral density, body composition and growth: a 7-year prospective study into young adulthood. J Bone Miner Res 22(1):110-8. 562. Siahanidou T, Mandyla H, Papassotiriou GP, Papasotiriou I, Chrousos GP (2006) Circulating Levels of Adiponectin in Preterm Infants. Arch Dis Child Fet Neon [Epub ahead of print]. 563. Nicolaidou P, Papadopoulou A, Matsinos YG, Georgouli H, Fretzayas A, Papadimitriou A, Priftis K, Douros K, Chrousos GP. (2006) Vitamin D Receptor Polymorphisms in Hypocalcemic Vitamin D- Resistant Rickets Carriers.Horm Res. 67(4):179-183 [Epub ahead of print]. 564. Spyridopoulos TN, Petridou ET, Skalkidou A, Dessypris N, Chrousos GP, Mantzoros CN, and the Obesity and Cancer Oncology Group (2007) Low Adiponectin Levels are Associated with Renal Cell Carcinoma: A Case-control Study. Inter J Cancer [Epub ahead of print]; 120: 1573-8. 565. Arditi JD, Venihaki M, Karalis KP and Chrousos GP (2007) Anti-proliferative Effect of Adiponectin on MCF7 Breast Cancer Cells: A Potential Hormonal Link between Obesity and Cancer. Horm Metabol Res 39: 9-13. 566. Alevizaki M, Cimponeriu A, Lekakis J, Papamichael C, Chrousos GP (2007) High Anticipatory Stress Plasma Cortisol and Increased Sensitivity to Glucocorticoids Predict Severity of Coronary Artery Disease in Subjects Undergoing Coronary Angiography. Metabolism 56: 222-6. 567. Kakourou T, Karachristou K and Chrousos GP (2007) A Case Series of Alopecia Areata in Children: Impact of Personal and Family History of Stress and Autoimmunity. JADV 21: 356-359. 568. Bartzeliotou AI, Margeli AP, Tsironi M, Skenderi K, Bacoula C, Chrousos GP, Papassotiriou I. (2007) Circulating levels of adhesion molecules and markers of endothelial activation in acute inflammation induced by prolonged brisk exercise. Clin Biochem. 2007 Jan 26; [Epub ahead of print]. 569. Krekoukia M, Nassis GP, Psarra G, Skenderi K, Chrousos GP, Sidossis LS. (2007) Elevated total and central adiposity and low physical activity are associated with insulin resistance in children. Metabolism. 56(2):206-13 570. Bai X, Wu J, Zhang Q, Alesci S, Manoli I, Blackman MR, Chrousos GP, Goldstein AL, Rennert OM, and 50

George P. Chrousos, M.D. Su YA. (2007) The Third-Generation Human Mitochondria-focused cDNA Microarray (hMitChip3) and its Bioinformatics Tool for Analysis of Gene Expression. BioTechniques 42:365-375 571. Chrousos GP, O’Dowd L, Uryniak T, Simpson B, Casty M, Goldman M (2007) Basal and Cosyntropin- stimulated Plasma Cortisol Concentrations, as Measured by High-performance Liquid Chromatography, in Children Aged 5 Months to <6 Years. J Clin Endocrinol Metab. [Epub ahead of print]. 572. Kino T, Rice KC and Chrousos GP (2007) The PPAR δ Agonist GW501516 Suppresses Interleukin-6 Action via STAT3 Inhibition. Eur J Clin Invest 37:425-433. 573. Xekouki P, Nikolakopoulou NM, Papageorgiou A, Livadas S, Voutetakis A, Magiakou MA, Chrousos GP, Spiliotis BE, Dacou-Voutetakis C. (2007) Glucose Dysregulation in Obese Children: Predictive, Risk, and Potential Protective Factors. Obesity (Silver Spring) 15: 860-869. 574. Kino T, Ichijo T, Amin ND, Kesavapany S, Amin ND, Wang Y, Kim N, Player A, Garabedian MJ, Kawasaki E, Pant HC and Chrousos GP (2007) Cyclin-dependent Kinase 5 Differentially Regulates the Transcriptional Activity of the Glucocorticoid Receptor through Phosphorylation: Clinical Implications for the Nervous System Response to Glucocorticoids and Stress. Mol Endocrinol. [Epub ahead of print]. 575. Papaevangelou V, Papassotiriou I, Vounatsou M, Chrousos G, Theodoridou M. (2007) Changes in leptin serum levels in HIV-infected children receiving highly active antiretroviral therapy. Scand J Clin Lab Invest. 67:291-6. 576. Nicolaidou P, Tsitsika A, Papadimitriou A, Karantana A, Papadopoulou A, Psychou F, Liakopoulou D, Georgouli H, Kakourou T, Chrousos G. (2007) Hereditary vitamin D-resistant rickets in Greek children: genotype, phenotype, and long-term response to treatment. J Pediatr Endocrinol Metab. 20:425-30. 577. Kino T, Boos TL, Sulima A, Siegel EM, Gold PW, Rice KC and Chrousos GP (2007) 3-O-formyl-20R,21- Epoxyresibufogenin Suppresses Interleukin 6-type Cytokine Actions by Targeting the gp130 Subunit : Potential Clinical Implications. J All Clin Immunol 120:437-444. 578. Trimis G, Moschovi M, Papassotiriou I, Chrousos G, Tzortzatou-Stathopoulou (2007) Early Indicators of Dysmetabolic Syndrome in Young Survivors of Acute Lymphoblastic Leukemia in Childhood as a Target for Preventing Disease. J Pediatr Hematol Oncol. 29:309-314. 579. Mantzoros CS, Trakatelli M, Gogas H, Dessypris N, Stratigos A, Chrousos GP, Petridou ET. (2007) Circulating adiponectin levels in relation to melanoma: A case-control study. Eur J Cancer 43:1430-6 580. Mills JL, Hediger ML, Molloy CA, Chrousos GP, Manning-Courtney P, Yu KF, Brasington M, England LJ (2007) Elevated Levels of Growth-Related Hormones in Autism and Autism Spectrum Disorder. Clin Endocrinol. 67:230-237 581. Siahanidou T, Mandyla H, Militsi H, Papassotiriou I, Chrousos G. (2007) Peptide YY (3-36) Represents a High Percentage of Total PYY Immunoreactivity in Preterm and Full-Term Infants and Correlates Independently With Markers of Adiposity and Serum Ghrelin Concentrations. Pediatr Res. 2007 Jun 25; [Epub ahead of print] 582. Livadas S, Magiakou MA, Mengreli C, Girginoudis P, Galani C, Smyrnaki P, Kanaka-Gantenbein C, Xekouki P, Chrousos GP, Dacou-Voutetakis C. (2007) Obesity and Attenuated Adiposity Rebound in Children with Congenital Hypothyroidism. Normalization of BMI Values in Adolescents. Horm Metab Res. 39:524-528 583. Pervanidou P, Kolaitis G, Charitaki S, Lazaropoulou Ch, Papassotiriou I, Hindmarsh P, Bakoula Ch, Tsiantis J and Chrousos GP (2007) The Natural History of Neuroendocrine Changes in Pediatric Post- traumatic Stress Disorder (PTSD) after Motor Vehicle Accidents: Progressive Divergence of Noradrenaline 51

George P. Chrousos, M.D. and Cortisol Concentrations over Time. Biol Psychiatry [Epub ahead of print] 584. Charmandari E, Kino T, Ichijo T, Jubiz W, Zachman K, Chrousos GP (2007) A Novel Point Mutation in Helix 11 of the Ligand-binding Domain (LBD) of the Human Glucocorticoid Receptor (GR) Gene Causing Generalized Glucocorticoid Resistance. J Clin Endocrinol Metab. [Epub ahead of print] 585. Minas V, Rolaki A, Kalantaridou SN, Sidiropoulos J, Mitrou S, Petsas G, Jeschke U, Paraskevaidis EA, Fountzilas G, Chrousos GP, Pavlidis N and Makrigiannakis A (2007) Intratumoral CRH Modulates Immuno-escape of Ovarian Cancer Cells through FasL Regulation. Br J Cancer [Epub ahead of print] 586. Vgontzas AN, S Pejovic S, Zoumakis E, Lin H-M, Bechtel C, EO Bixler EO, A. Sarrigiannidis A, Basta M, Chrousos GP (2007) Hypothalamic-Pituitary-AdrenalAxis Activity in Obese Men with and without Sleep Apnea: Effects of Continuous Positive Airway Pressure Therapy. J Clin Endocrinol Metab [Epub ahead of print] 587. Pervanidou P, Kolaitis G, Charitaki S, Margeli A, Ferentinos S, Bakoula C, Lazaropoulou C, Papassotiriou I, Tsiantis J and Chrousos GP (2007) Elevated Morning Serum Interleukin (IL)-6 or Evening Salivary Cortisol Concentrations Predict Posttraumatic Stress Disorder in Children and Adolescents Six Months after a Motor Vehicle Accident. Psychoneuroendocrinology [Epub ahead of print] 588. Pavlatou MG, Mastorakos G, Lekakis I, Liatis, Vamvakou G, Zoumakis E, Papassotiriou I, Rabavilas AD, Katsilambros N and Chrousos GP (2007) Chronic Administration of an Angiotensin II Receptor Antagonist Resets the Hypothalamic-pituitary-adrenal Axis and Improves the Affect of Patients with Diabetes Mellitus Type 2: Preliminary Results. Stress [Epub ahead of print] 589. Hoffman KE, Derdak J, Bernstein D M, Reynolds JC, Avila NA, Gerber L, Steinberg S, Chrousos G, Mackall CL and Mansky PJ (2007) Metabolic Syndrome Traits in Long-term Survivors of Pediatric Sarcoma at a Single Institution. Ped Blood and Cancer 590. Shrivastav S, Kino K, Cunningham T, Ichijo T, Schubert U, Heinklein P, Chrousos GP and Kopp JB (2007) HIV-1 Vpr suppresses transcriptional activity of PPARγ and inhibits adipocyte differentiation: Implications for HIV-associated lipodystrophy. Mol Endo 591. Gogas H, Trakatelli M, Dessypris N, Terzidis A, Katsambas A, Chrousos GP, Petridou ET (2007) Melanoma risk in association with serum leptin levels and lifestyle parameters: a case–control study. Ann Oncol B. REVIEWS-CHAPTERS-LETTERS (*PEER REVIEWED) 1. Moutsopoulos H.M., Chrousos G.P., Papavassiliou J.T. (1976) Autoimmunity and Slow Viruses. Materia Medica Graeca, 4, (1), 76-84. 2. Moutsopoulos H.M., Chrousos G.P., Papavassiliou J.T. (1976) Humoral Thymic Products (Thymosin- Thymopoietin): Reality and Perspective. Materia Medica Graeca, 4, (1), 85-89. 3. Chrousos G.P. (1976) Bacteriocinogeny in Salmonellae. Doctorate Thesis, Athens University. 4. Karatzas N.B., Chrousos G.P. (1976) The Adrenergic Neurochemical Transmission and the Drugs that Influence It. Iatriki, 30: 311-325. 5. Chrousos G.P., Karatzas N.B. (1977) The Systolic Intervals In Hemodialysis. Changes Related to Starling's Law. Hellenic Cardiological Review (Athens), 18: 225-231. 52

George P. Chrousos, M.D. 6. Papadoyiannis D.E., Clouvas P., Chrousos G.P., Karatzas N.B. (1977) A Blind Comparative Trial of a Beta-Blocker (timolol), a Diuretic and a Combination of the Two in the Treatment of Hypertension. Iatriki, 32: 391-395. 7. Chrousos G.P., Karatzas N.B. (1977) The Problem Oriented System and Its Usefulness. Iatriki, 31: 348352. 8. Cornblath M.D., Chrousos G.P., Adams A. (1979) Hormone Interactions and Glucose Homeostasis. Acta Paediatrica Belg. 32: 231-238. 9. Chrousos G.P., Greydanus D. (1981) Adolescent Medicine: Necessity and Perspectives. Iatriki 40: 252- 257. 10. Chrousos G.P., Cutler G.B., Simons S., Pons M., Moriarty R.M., Loriaux D.L. (1982) Development of Antiglucocorticoids with Potential Clinical Usefulness. In: Progress in Research and Clinical Applications of Corticosteroids, Eds. H.J. Lee, and T.J. Fitzerald, Heyden and Son Co., Philadelphia, p. 152-156. 11. Lipsett M.B., Chrousos G.P., Loriaux D.L. (1982) Glucocorticoid Receptor Defects: Studies in Humans and a Primate Model in "Proceedings of the International Symposium on Hormone Receptors and Receptor Diseases." Excerpta Medica, Amsterdam, H. Imura and H. Kuzua (Eds.) p. 187-193. 12. Chrousos G.P., Munabi A., Cutler G.B. Jr., Loriaux D.L. (1982) Diagnosis of Late-Onset 21- Hydroxylase Deficiency by Plasma 17-Hydroxyprogesterone Response to ACTH. Ann. Int. Med. (Letter to the Editor) 97: 281-282. 13. Chrousos G.P., Loriaux D.L., Brandon D., Merriam G.R., Johnson E.O., Lipsett M.B. (1983) Primary Cortisol Resistance: A Familial Syndrome and an Animal Model. J. Steroid Biochem. 19: 567-576. 14. Chrousos G.P., Cutler G.B. Jr., Sauer M., Simons S.S. Jr., Loriaux D.L. (1983) Development of Glucocorticoid Antagonists: Pharmacol. Ther. 20(2): 263-281. 15. Chrousos G.P. (1983) Pathophysiology of the Endocrine Glands. In: "Basic Principles of Pathophysiology" Eds. H.M. Moutsopoulos and D.S. Emmanuel, Litsas Press, Athens. p. 116-168. 16. Chrousos G.P., Schulte H.M., Loriaux D.L., Cutler G.B. Jr., Gold P.W. (1983) Corticotropin Releasing Factor: Basic and Clinical Studies. Psychopharmacol. Bull. 19: 416-421. 17. Becker L., Gold P.W., Chrousos G.P. (1983) Analogies betweeen Cushing's Disease and Depression: A Case Report. General Hospital Psychiatry. 5: 89-91. 18. *Schulte H.M., Chrousos G.P., Chatterji D.C., Gold P.W., Oldfield E.H., Loriaux D.L. (1983) Safety of Corticotropin-Releasing Factor. The Lancet Vol. I (o 8335) p. 1222 (Letter to the Editor). 19. Healy D.L., Hall N.R., Schulte H.M., Chrousos G.P., Goldstein A.L., Loriaux D.L., Hodgen G.H. (1984) Pituitary Responses to Acute Administration of Thymosin in Prepubertal Primates. In: "Thymic Hormones and Lymphokines, Ed. Alan Goldstein, Plenum Press, New York, p. 365-374. 20. *Gold P.W., Chrousos G.P., Kellner C., Post R., Schulte H., Oldfield E.H., Loriaux D.L. (1984) Basic and Clinical Studies with Corticotropin Releasing Factor: Psychiatric Implications. Am. J. Psychiatry. 141: 619 627. 21. Chrousos G.P., Tomita M., Brandon D., Loriaux D.L., Lipsett M.B. (1984) Glucocorticoid Insensitivity in Man and Nonhuman Primates. In: Labrie, F. and Prouix, L. (Eds.) Proceedings of the 7th International 53

George P. Chrousos, M.D. Congress of Endocrinology, Elsevier Science Pub., Amsterdam. p. 853-856. 22. Crawley J.N., Ninan P.T., Pickar D., Chrousos G.P., Scolnick P., Paul S.M. (1984) Behavioral and A Physiological Responses to Benzodiazepine Receptor Antagonists. Psychopharmacol. Bull. 20: 403-407. 23. Schulte H.M., Chrousos G.P., Reinwein D., Loriaux D.L. (1984) Der Kortikotropin-Releasing- Faktorstimulations-test inder Differential diagnose des Cushing-Syndroms. Verhandlungender Deutschen Gesellschaft fur Innere Medizin. Endokrinologie II. 90: 508-511. 24. Chrousos G.P., Nieman L., Nisula B., Schulte H.M., Oldfield E.H., Gold P.W., Cutler G.B. Jr., Loriaux D.L. (1984) Corticotropin-releasing Factor Stimulation Test. (Letter to the Editor) N. Engl. J. Med. 311:472-473. 25. Chrousos G.P., Nieman L., Healy D., Spitz I., Cutler G.B. Jr., Brandon D., Merriam G.R., Hodgen G., Bardin C.W., Loriaux D.L. (1984) Antiglucocorticoids: General Aspects and Clinical Implications. In: Glucocorticoids: Research and Therapy. Eds. H. Fehm, J. Kobberling, and H. Kruskemper Perimed Fachbush, Verlagsgesellschaft, Erlangen. p. 54-71. 26. Chrousos G.P., Calabrese J.R., Loriaux D.L., Schuermeyer T., Avgerinos P., Cutler G.B. Jr., Gold P.W. (1985) Corticotropin Releasing Factor: Basic Studies and Clinical Implications. Prog. in Neuro- Psychopharmacol. and Biol. Psychiat. 9: 349-359. 27. Hall N., McGillis J.P., Spangelo B.L., Healy D.L., Chrousos G.P., Schulte H.M., Goldstein A.L.(1985) Thymic Hormone Effects on the Brain and Neuroendocrine Circuits. In: Neural Modulation of Immunity. Eds. R. Guillemen, M. Cohen and T. Melnechuk, Raven Press, New York p. 179-193. 28. Lipsett M.B., Chrousos G.P., Brandon D.D., Tomita M., Loriaux D.L. (1985) The Defective Glucocorticoid Receptor in Man and Nonhuman Primates. Rec. Prog. Horm. Res. 41: 199-247. 29. Udelsman R., Gallucci T.W., Gold P.W., Renquist D.L., Loriaux D.L., Chrousos G.P. (1985) Human Corticotropin Releasing Hormone as a Vasodilator Causing Systemic Hypotension. In: The Adrenal Gland and Hypertension. F. Mantero, Biglieri E., Funder, J. and Scoggins, B. (Eds) Serono Symposia Series, Vol. 27, Raven Press, New York, 219-224. 30. *Gold P.W., Chrousos G.P. (1985) Clinical Studies with Corticotropin Releasing Factor: Implications for the Diagnosis and Pathophysiology of Depression, Cushing's Disease and Adrenal Insufficiency. Psychoneuro- endocrinology (awarded the Kurt Richter Prize for Psychoneuro-endocrinology) 10: 401-419. 31. Chrousos G.P., Evans M., McCluskey J., Fletcher J., Loriaux D.L., Schulman J. (1985) Prenatal Treatment of Congenital Adrenal Hyperplasia. Annals of the New York Academy of Sciences, New York, NY. 458: 156-164 32. Nieman L.K., Chrousos G.P., Kellner C., Spitz I., Nisula B.C., Cutler G.B. Jr., Merriam G.R., Bardin C.W., Loriaux D.L. (1985) Use of the Glucocorticoid Antagonist RU 486 in the Treatment of Cushing's Syndrome. In: The Antiprogestin Steroid RU 486 and Human Fertility Control. Eds. S.J. Segal and E.E. Baulieu. Plenum Press, New York. 339-345. 33. Nieman L.K., Healy D., Spitz I., Merriam R., Bardin C.W., Loriaux D.L., Chrousos G.P. (1985) Use of Single Doses of the Antiprogesterone Steroid RU 486 for Induction of Menstruation in Normal Women. In: The Antiprogestin Steroid RU 486 and Human Fertility Control. Eds. S.J. Segal and E.E. Baulieu. Plenum Press, New York 279-283. 34. Nottelman E.D., Susman E.J., Blue J.H., Inoff G.E., Dorn L.D., Cutler G.B. Jr., Loriaux D.L., Chrousos G.P. (1985) Gonadal and Adrenal Hormone Correlates of Adjustment in Early Adolescence. In: 54

George P. Chrousos, M.D. Biological-psychosocial Interactions in Early Adolescence: A Life-span Perspective. Eds. R.M. Lerner and T.T. Foch. Erlbaum, Hillsdale, N.J. p. 303-323. 35. Oldfield E.H., Chrousos G.P., Nieman L.K., Schaaf M., Cutler G.B. Jr., Loriaux D.L., Doppman J.L. (1985) Inferior Petrosal Venous Sampling in Lateralization of ACTH-secreting Pituitary Microadenomas. N. Engl. J. Med. (Letter to the Editor) 312: 1457-1458. 36. Udelsman R., Loriaux D.L., Chrousos G.P. (1985) Reevaluation of the Role of Glucocorticoids in Surgical Stress. Surgical Forum 36: 18-20. 37. Gold P.W., Kling M., Calabrese J.R., Gallucci W.T. Kellner C.H., Post R.M., Cutler G.B., Avgerinos P.C., Loriaux D.L., Chrousos G.P. (1985) Clinical Applications of Corticotropin Releasing Factor. In: Nemeroff, C.B., (Ed): Handbook of Clinical Neuroendocrinology. Raven Press, New York. 38. *Chrousos G.P., Schuermeyer T., Oldfield E., Doppman J., Schulte H.M. Gold P.W., Loriaux D.L. (1985) The Clinical Applications of Corticotropin-Releasing Factor. A Conference of the Combined Clinical Staff of the National Institutes of Health. Ann. Int. Med. 102: 344-358. 39. Lipsett M.B., Tomita M., Brandon D., Loriaux D.L., Chrousos G.P. (1986) Cortisol Resistance in Man. In: Chrousos, G.P., Loriaux, D.L., and Lipsett, M.B. (Eds) Steroid Hormone Resistance: Mechanisms and Clinical Aspects. Plenum Press, New York, p. 97-110. 40. Winterer J., Chrousos G.P., Loriaux D.L., Cutler G.B. (1986) The Adrenal Suppressive Effect of Hydrocortisone in Congenital Adrenal Hyperplasia. Annals of the New York Academy of Sciences, New York, NY 458: 182-192. 41. Lipsett M.B., Chrousos G.P., Loriaux D.L. (1986) The Steroid Binding Proteins in the Syndrome of Glucocorticoid Resistance and in New World Primates. In: The Role of Receptors in Biology and Medicine. B. O'Malley and A. Gotto (Eds). Raven Press, New York p. 51-61. 42. Chrousos G.P., Loriaux D.L., Tomita M., Brandon D., Lipsett M.B. (1986) The New World Primates as Animal Models of Cortisol Resistance. In: Chrousos G.P., Loriaux D.L., Lipsett M.B., (Eds). Steroid Hormone Resistance: Mechanisms and Clinical Aspects, Plenum Press, New York, p. 129-144. 43. Chrousos G.P., Loriaux D.L. (1986) Cushing's Syndrome. In: Conn's Current Therapy. Ed. Robert E. Rakel, W.B. Saunders Co., Philadelphia p. 499-502.44. Gold P.W., Calabrese J., Kling M., Avgerinos P., Khan I., Gallucci W.T., Tomai T., Chrousos G.P. (1986) Abnormal Pituitary-Adrenal Responses to Corticotropin Releasing Factor in Depression. Prog. Neuropsychopharmacol. Biol. Psychiatry. 10: 57-65. 44. Winterer J., Cutler G.B. Jr., Chrousos G.P., Feuillan P.P., Loriaux D.L. (1986) Management of CongenitalAdrenal Hyperplasia. J. Pediatrics (Letter to the Editor) 109: 389-90. 45. Chrousos G.P., Maclusky N. Brandon D., Tomita M., Loriaux D.L., Lipsett M.B. (1986) Progesterone Resistance. In: Chrousos, G.P., Loriaux, D.L., and Lipsett, M.B. (Eds). Steroid Hormone Resistance: Mechanisms and Clinical Aspects, Plenum Press, New York, p. 317-328. 46. Gold P.W., Kling M., Calabrese J., Kellner C., Roy A., Gwirtsman H., Post R.M., Pickar D., Avgerinos P.C., Loriaux D.L., Chrousos G.P. (1987) Corticotropin Releasing Factor in the Pathophysiology of Hypercortisolism in Depression. In: Hormones and Depression, U. Halbreich (Ed) Raven Press, New York. 77-89. 47. Chrousos G.P., Loriaux D.L. (1987) Cushing's Syndrome. In: Conn's Current Therapy. Ed. Robert E. Rakel. W.B. Saunders Co., Philadelphia p. 495-498. 55

George P. Chrousos, M.D. 48. Susman E., Nottelman E., Inoff G., Dorn L., Chrousos G.P. (1987) Hormonal Influences on Aspects of Psychological Development. J. Adol. Health Care 8: 492-504. 49. Chrousos G.P., Luger A., Avgerinos P.C., Kling M., Oldfield E., Nieman L.K., Schuermeyer T., Loriaux D.L., Gold, P.W. (1987) Corticotropin Releasing Hormone: Relevance to Physiology and Pathophysiology. In: Recent Advances in Adrenal Regulation and Function, Raven Press, New York, 121- 135. 50. Nieman L.K., Udelsman R., Loriaux D.L. and G.P. Chrousos (1987) Antiglucocorticoids:. In: Recent Advances in Adrenal Regulation and Function. Raven Press, New York, 235-242. 51. Udelsman R., Loriaux D.L., Chrousos G.P. (1987) Surgical Stress: The Role of Glucocorticoids and Catecholamines. In: D'Agata R., and G.P. Chrousos (Eds) Recent Advances in Adrenal Regulation and Function. Raven Press, New York, 253-263. 52. Calogero A., Gallucci W., Tomai T., Loriaux D.L., Chrousos, G.P., P.W. Gold (1987) The GABA/Benzodiazepine System is Involved in the Regulation of Hypothalamic CRH Secretion In Vitro. In: D'Agata R., and Chrousos G.P. (Eds) Recent Advances in Adrenal Regulation and Function. Raven Press, New York, 279-284. 53. Gold P.W., Kling M.A., Calabrese J.R., Post R.M., Roy A., Nieman L.K., Cutler G.B. Jr., Loriaux D.L. Chrousos G.P. (1987) Corticotropin Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease. (Letter to the Editor) N. Engl. J. Med. 316: 218-219. 54. Laue L., Chrousos G.P. (1987) Antiinflammatory Steroid Action: Receptor-mediated Effects on Prostanoid Synthesis. In: D'Agata R. and G.P. Chrousos (Eds). Recent Advances in Adrenal Regulation and Function. Raven Press, New York, 293-302. 55. Gold P.W., Gwirtsman H., Brandt H., Jimerson D., Loriaux D.L., Chrousos G.P. (1987) Abnormal Hypothalamic Pituitary-Adrenal Function in Anorexia Nervosa. (Letter) N.Engl. J. Med. 316: 219-220. 56. Gold P.W., Kling M.A., Khan J., Calabrese J.R., Kalogeras K., Post R.M., Avgerinos P., Loriaux D.L. and G.P. Chrousos (1987) Corticotropin Releasing Hormone: Relevance to Normal Physiology and to the Pathophysiology and Differential Diagnosis of Hypercortisolism and Adrenal Insufficiency. In: Hypothalamic Dysfunction in Neuropsychiatric Disorders. Eds. D. Nerozzi, F.K. Goodwin and E. Costa. In the series: Advances in Biochemical Psychopharmacology, Vol 43, Raven Press, NY pp. 183-200. 57. Schürmeyer T.H., Schulte H.M., Avgerinos P., Tomai T.P., Loriaux D.L., Gold P.W., Chrousos G.P. (1987) Pharmacology of Ovine and Human CRH. Horm. Metabol. Res. 16: 24-30. 58. Avgerinos P., Schuermeyer T., Udelsman R., Nieman L.K., Gold P.W., Loriaux D.L., Chrousos G.P. (1987) Human Corticotropin Releasing Factor as a Tool for Studying the Pulsatile Function of the Hypothalamic-pituitary-adrenal Axis. In: W. Crowley and J.F. Hofler (Eds) Episodic Hormone Secretion: Methods of Analysis and Normative Data. Churchill Livingstone, New York p. 389-401. 59. Peacock J., Laue L., Chrousos G.P., Gallucci W., Norton N. (1987) Glucocorticoid Receptor Mediates Rat Sarcoma Growth. Surgical Forum 38: 396-398. 60. *Gold P.W., Goodwin F., Chrousos, G.P. (1988) Clinical and Biochemical Manifestations of Depression: Relationship to the Neurobiology of Stress. (Part I) N. Engl. J. Med. 319: 348-353. 61. Chrousos G.P. (1988) Endocrine Tumors, In: Pizzo P.A. and Poplack D.G. (Eds) Principles and Practice of Pediatric Oncology. J.B. Lippincott Co., New York. 733-757. 56

George P. Chrousos, M.D. 62. Chrousos G.P., Loriaux D.L. (1988) Cushing's Syndrome. In: Conn's Current Therapy, Ed. R.E. Rakel, W.B. Saunders Co., New York. 525-529. 63. Margioris A., Grino M., Gold P.W., Rabin D., Chrousos G.P. (1988) Human Placenta and the Hypothalamic-pituitary-adrenal Axis. In: Mechanisms of Physical and Emotional Stress, Plenum Publ. Corp. New York. Adv. Exp. Med. Biol. 245: 389-398. 64. Chrousos G.P., Loriaux D.L., Gold P.W. (1988) The Concept of Stress and Its Historical Development. In: Mechanisms of Physical and Emotional Stress, Plenum Publ. Corp. New York. Adv. Exp. Med. Biol. 245: 3-7. 65. Rabin D., Gold P.W., Margioris A., Chrousos G.P. (1988) Stress and Reproduction: Interactions Between the Stress and Reproductive Axes. In: Mechanisms of Physical and Emotional Stress, Plenum Publ. Corp. New York. Adv. Exp. Med. Biol. 245: 377-387. 66. Nieman L.K., Loriaux D.L., Chrousos G.P. (1988) Corticotropin Releasing Factors. In: Central Nervous System Endocrinology. M. Cohen and P. Foa (Eds). Springer-Verlag Co., New York, NY 14-45. 67. Bernardini R., Luger A., Gold P.W., Chiarenza A., Legakis J., Chrousos G.P. (1988) Cytokines Stimulate Pituitary-adrenal Function via Activation of the CRH Neuron. In: New Trends in Brain and Female Reproductive Function. F. Petraglia (Ed) CIG Edizioni Internationali, Milan p. 35-39. 68. Chrousos G.P., Laue L., Kawai S., Nieman L.K., Udelsman R., Loriaux D.L.(1988) Glucocorticoids and Glucocorticoid Antagonists: Lessons from RU 486. Kidney International Vol. 34, Suppl 26, p. S-18-S-23. 69. Laue L., Loriaux D.L., Chrousos G.P. (1988) Glucocorticoid Antagonists and the Role of Glucocorticoids at the Resting and Stress State. In: Chrousos G.P., Loriaux D.L. and Gold P.W. (Eds) Mechanism of Physical and Emotional Stress. Plenum Press, New York, NY. Adv. Exp. Med. Biol. 245: 225-235. 70. Gold P.W., Pigott T.A., Kling M.K., Kalogeras K., Chrousos G.P. (1988) Basic and Clinical Studies with Corticotropin Releasing Hormone: Implications for a Possible Role in Panic Disorder. Psychiatr. Clin. North America Vol. 11(2) 327-334. 71. Calogero A., Bernardini R., Gold P.W., Chrousos G.P. (1988) Regulation of CRH Secretion in Vitro: Potential Clinical Implications. In: Mechanisms of Physical and Emotional Stress. Plenum Publ., New York. Adv. Exp. Med. Biol. 245: 167-181. 72. Udelsman R., Chrousos G.P. (1988) Hormonal Response to Surgical Stress. In: Mechanisms of Physical and Emotional Stress. Plenum Publ., New York. Adv. Exp. Med. Biol. 245: 267-272. 73. Luger A., Deuster P.A., Gold P.W., Loriaux D.L., Chrousos G.P. (1988) Hormonal Responses to the Stress of Exercise. Adv. Med. Biol. 245: 273-283. 74. Susman E.J., Nottelman E.D., Dorn L.D., Inoff-Germain G., Chrousos G.P. (1988) Physiological and Behavioral Aspects of Stress in Adolescence. In: Mechanisms of Physical and Emotional Stress. Plenum Press New York. Adv. Exp. Biol. Med. 245: 341-352. 75. Gold P.W., Whitfield H.J., Kling M.A., Demitrack M.A., Brandt H.A., Chrousos G.P. (1988) The Relevance of Corticotropin Releasing Hormone to Normal Physiology and to Pathophysiology of Adrenal Function. In A.F. Schatzberg and C.B. Nemeroff (eds) The Hypothaamic-Pituitary-Adrenal Axis. Physiology, Pathophysiology and Psychiatric Implications. Raven Press, New York, p. 101-113. 76. Gold P.W., Kling M.A., Demitrack M., Whitfield H.J., Kalogeras K., Loriaux D.L., Chrousos G.P. (1988) Clinical Studies with Corticotropin Releasing Hormone: Implications for Hypothalamic-Pituitary-Adrenal 57

George P. Chrousos, M.D. Dysfunction in Depression and Related Disorders. In: Ganten D., and Pfaff D. (eds) Neuroendocrinology of Mood. Current Topics in Endocrinology Vol. 8, Springer-Verlag, New York p. 55-77. 77. Gold P.W., Kling M., Whitfield H., Rabin D., Margioris A., Kalogeras D., Demitrack M., Loriaux D.L., Chrousos G.P. (1988) The Clinical Implications of Corticotropin Releasing Hormone. In: Mechanisms of Physical and Emotional Stress. Plenum Publ. New York. Adv. Exp. Biol. Med. 245: 507-519. 78. Brandon D.D., Markwick A., Chrousos G.P., Loriaux D.L. (1988) Glucocorticoid Resistance in a Family and New World Primates. Cancer Res. (suppl). 49: 2203S-2213S. 79. *Gold P.W., Goodwin F.K., Chrousos G.P. (1988) Clinical and Biochemical Manifestations of Depression: Relationship to the Neurolobiology of Stress. (Part 2). N. Engl. J. Med. 319: 413-420. 80. Laue L., Kawai S., Udelsman R., Nieman L.K., Brandon D.D., Gallucci W.T., Gold P.W., Loriaux D.L., Chrousos G.P. (1989) Glucocorticoid Antagonists: Pharmacological Attributes of the Prototype Antiglucocorticoid RU 486. Chapter 13. In: Lichtenstein L.M., Claman H., Oronsky A. and Schleimer R.P. (Eds) Antiinflammatory Steroid Action: Basic and Clinical Aspects. Academic Press, NY p. 303-329. 81. Kamilaris T., Chrousos G.P. (1989) Tests of Adrenal Function. In "Diagnostic Endocrinology" Eds W.T. Moore and R. Eastman. B.C. Decker Inc. Toronto, CA. 79-109. 82. Chrousos G.P., Laue L., Nieman L.K., Udelsman R., Kawai S., and Loriaux D.L. (1989) Clinical Applications of RU 486, A Prototype Glucocorticoid and Progestin Antagonist. In: F. Mantero R. Takeda, B.A. Scoggins, E.G. Biglieri and J. Funder (Eds) The Adrenal and Hypertension: From Cloning to Clinic. Serono Symposia Series, Raven Press, NY p. 273-284. 83. Chrousos G.P., Gold P.W. (1989) Clinical Implications of Corticotropin Releasing Hormone. F. Mantero and J. Funder (Eds) The Adrenal Cortex: From Cloning to Clinic. Serono Symposia Series, Raven Press, NY p. 259-272. 84. Smith M.A., Kling M.A., Whitfield H.J., Brandt H.A., Demitrack M.A., Geracioti T.D., Chrousos G.P., Gold P.W. (1989) Corticotropin Releasing Hormone. From Endocrinology to Psychobiology. Horm. Res. 31: 66-71. 85. Gold P.W., Altemus M, Goodwin F.K., Chrousos G.P. (1989) Brain-Mind Interactions. N. Engl. J. Med. (Letter to the Editor) 320: 869-870. 86. Kling M.A., Whitfield H.J., Brandt H.A., Demitrack M.A., Kalogeras K., Geracioti T.D., Perini G.I., Calabrese J.R., Chrousos G.P. and P.W. Gold (1989) Effects of Glucocorticoid Antagonism with RU 486 on Pituitary-adrenal Function in Patients with Major Depression: Time-dependent Enhancement of Plasma ACTH Secretion. Psychopharmacology Bull. 25: 466-472. 87. Sternberg E.M., Wilder R.L., Chrousos G.P., Gold P.W., Young W.S., Bernardni R., Calogero A.E., Hill J.M., Kamilaris T., Listwak S.J. (1988) The Role of the Hypothalamic-pituitary-adrenal Axis in Susceptibility to Arthritis. IN: Cushing's Syndrome and Other Hypercortisolemic States. Raven Press, New York. p. 183-188. 88. Bernardini R., Rabin D., Margioris A., Grino M., Gold P.W., Chrousos G.P. (1989) The Hypothalamic- pituitary-adrenal Axis in Aging. In: Psychoneuroendocrinology of Aging. Fidia Research Series Vol. 16 Springer Verlag, Padova, p. 75-81. 89. Kling M.A., Perini G.I., Demitrack M.A., Geracioti T., Linnoila M., Chrousos G.P., Gold P.W. (1989) Stress-responsive Neurohormonal Systems and the Symptom Complex of Affective Disorder. Psychopharmacol. Bull. 25: 12-18. 58

George P. Chrousos, M.D. 90. Chrousos G.P., Udelsman R., Margioris A., Gold P.W., Oldfield E.H., Schuermeyer T.H., Schulte H.M., Dopman J., Loriaux D.L. (1989) Corticotropin-releasing Factor. Physiological and Clinical Implications. In: E.E. Muller and R.M. MacLeod (Eds). Neuroendocrine Perspectives. Vol 7, page 49-76 Elsevier Biomedical Press, New York. 91. Cutler G.B. Jr., Schiebinger R.J., Albertson B.D., Cassorla G.B., Chrousos G.P., Comite F., Booth J.D., Levine J., Hobson W.C., Loriaux D.L. (1990) The Adrenarche (Human and Animal). In: "Second International Conference on the Control of the Onset of Puberty", Eds M. Grumbach, P. Sizonenko, and M. Aubert. Williams and Wilkins, Baltimore, p. 506-533. 92. Loughlin T., Chrousos G.P. (1990) Hypoaldosteronism, In: Becker K.L. (Ed) Principles and Practice of Endocrinology and Metabolism. J.B. Lippincott Co., New York. 643-649. 93. Cassorla F., Chrousos G.P. (1990) The Adrenogenital Syndrome. In: Becker K.L. (ed.) Principles and Practice of Endocrinology and Metabolism. J.B. Lippincott Co., New York. 604-613. 94. Bernardini R., Calogero A.E., Gold P.W., Chrousos G.P. (1990) Mediators of the Immune Response. Relationships with Hypothalamis Corticotropin Releasing Hormone and Pituitary Adrenal Corticotropin. In: Cushing's syndrome and Other Hypercortisolemic States. Eds. D. Ludecke, G. Chrousos and G. Tolis. Raven Press, New York p. 15-20. 95. Luger A., Deuster P., Chrousos G.P. (1990) Hypercortisolism of Exercise: In: Cushing's syndrome and Other Hypercortisolemic States. Eds: D. Ludecke, G. Chrousos and G. Tolis, Raven Press, New York p. 77-82. 96. Margioris A.N., Brockmann G., Gomez M.J., Chrousos G.P. (1990) Paracrine Effects of Placental Corticotropin Releasing Hormone. In: Cushing's Syndrome and Other Hypercortisolemic States. Eds: D. Ludecke, G Chrousos and G. Tolis, Raven Press, New York p. 189-192. 97. Meyerhoff J.L., Oleshansky M.A., Kalogeras K.T., Mougey E.H., Chrousos G.P. and Granger L.G. (1990) Neuroendocrine Responses to Emotional Stress: Possible Interactions Between Circulating Factors and Anterior Pituitary Hormone Release. In Circulating Regulatory Factors and Neuroendocrine Function: Advances in Experimental Biology and Medicine, ed. by J.C. Porter and D. Jezova, Plenum Press, 274: 91- 111. 98. Coutifaris C., Ringler G.E., Reed K., Margioris A., Chrousos G.P., Strauss J.F. III (1990) The Placenta and Stress: Effects of Adenylate Cyclase Activators and of Glucocorticoids on the Endocrine Function of Trophoblastic Cells in Culture. In: Neuroendocrine Regulation of Reproduction. Eds: S.S.C. Yen and W.W. Vale. Serono Symposia USA, Norwell, Mass. p. 95-103. 99. Chrousos G.P. (1990) Glucocorticoid Resistance. Birth Defects Encyclopedia. Alan R. Liss. Inc. New York. 784-785. 100. Margioris A.N., Chrousos G.P. (1990) Cushing's syndrome: Diagnostic Evaluation. In: Endocrine Hypertension. E. Biglieri (editor), Raven Press, N.W. 99-111. 101. Sternberg E., Wilder R., Gold P.W., Chrousos G.P. (1990) A Defect in the Central Component of the Immune System-hypothalamic-pituitary-adrenal Axis Feedback Loop is Associated with Susceptibility to Arthritis and Inflammatory Disease. Ann. New York Acad. Sci. 594: 289-92. 102. Susman E., Nottelman E., Dorn L., Gold P.W., Chrousos G.P. (1989) The Physiology of Stress andBehavioral Development. In: Coping with Uncertainty: Biological, Behavioral and Developmental Perspectives. D.S. Palermo and J. Kagan (Eds). Lawrence Erlbaum Assoc., Inc., Hillsdale, N.J., 17-38. 59

George P. Chrousos, M.D. 103. Sternberg E.M., Wilder R.L., Chrousos G.P., Gold P.W. (1991) Stress Responses and the Pathogenesis of Arthritis. In: Stress Neuropeptides, and Systemic Disease. Eds. J. A. McCubbin, P. Kaufman and C. Nemeroff, Academic Press, 287-300. 104. Hurley D., Chrousos G.P. (1991) Glucocorticoid Resistance. Current Therapy in Endocrinology and Metabolism. W. Bardin (Ed.) B.C. Decker, Inc., Philadelphia, 150-151. 105. Gomez M.T., Chrousos G.P. (1991) Cushing's Syndrome. Current Therapy in Endocrinology and Metabolism. W. Bardin (Ed.) B.C. Decker, Inc., Philadelphia, 134-137. 106. Kamilaris T., Chrousos G.P. (1991) Cushing's Syndrome in R-Rakel (Ed.) Conn's Current Therapy W.B. Saunders Co., Philadelphia, 572-578. 107. Gomez M.T., Chrousos G.P. (1991) Chronic Adrenal Insufficiency. In: Conn's Current Diagnosis. W.B. Saunders Co., Philadelphia, 865-868. 108. Laue L., Gold P.W., Richmond A., Chrousos G.P. (1991) The Hypothalamic-pituitary-adrenal Axis in Anorexia and Bulimia Nervosa In: L.A. Barness (Ed.), Advances in Pediatrics 287-316. 109. Flack M., Chrousos G.P. (1993) Neoplasms of the Adrenal Cortex In: Cancer Medicine, R. Holland et al. (Eds.) Third Edition. Lea and Fibinger Inc., New York Vol 1, 1147-1153. 110. Liapi C., Chrousos G.P. (1992) "Glucocorticoids". Chapter 41. In: Pediatric Pharmacology, S.J. Yaffe and J.V. Aranda (Eds). 2nd Edition Saunders Publ Co. New York 466-475. 111. Karalis K., Gold P.W., Chrousos G.P. (1992) Hypothalamic-pituitary-adrenal Function in Eating Disorders. In: Psychiatry: A World Perspective Vol. 2 Neurosciences in Psychiatry. C. Stefanis, C. Soldatos, A. Rabavilas. Excerpta Medica 537-544. 112. Stratakis C., Karl M., Hurley D., Accili D., Vamvakopoulos N., Rorer E., Constantine K., Taylor S., Chrousos G.P. (1991) A Point Mutation in the Hormone Binding Domain of the Glucocorticoid Receptor in Familial Glucocorticoid Resistance. Horizons in Endocrinology. Eds., M. Maggi and V. Geenen, Serono Symposia Series, Vol. 76:3-8. 113. Nottelman E., Susman E., Chrousos G.P. (1990) Hormones and Adjustment in Puberty. In: Adolescence and Puberty, J. Bancroft and J. Reinisch (Eds). Kinsey Institute Symposia Series 88-123. 114. Rabin D., Chrousos, G.P. (1991) Adrenal Androgens In: Lerner R., Peterson A., and Brooks-Gunn J. Eds, The Encyclopedia of Adolescence. Garland Publ. New York. Vol. 1:53-55. 115. Rabin D., Chrousos G.P. Gonadal Androgens. (1991) In: Lerner R., Petersen A and Brooks-Gunn J. Eds, The Encyclopedia of Adolescence. Garland Publ. New York. Vol 1:56-59. 116. Gold P.W., Kling M.A., Whitfield H.J., Demitrack M.A., Kalogeras K., Loriaux D.L., Chrousos G.P. (1988) The Clinical Implications of Corticotropin Releasing Hormone. In: Progress in Endocrinology Imura H., Shizuma K, Yoshida S. (Eds) Elsevier Science Publishers, Excerpta Medica New York 897-914. 117. Margioris A., Stratakis C., Chrousos G.P. (1991) Glucocorticoids and Other Adrenal Steroids. Chapter 35. In: Human Pharmacology: Molecular to Clinical. L. Winegard, T. Brody, J. Larner and A. Schwartz (Eds). Mosby Yearbook, St. Louis, p 484-493. 118. Johnson E.O., Kamilaris T.C., Chrousos G.P., Gold P.W. (1992) Mechanisms of Stress: A Dynamic Overview of Hormonal and Behavioral Homeostasis. J. Neurosc. Biobehav. Rev. 16:115-130. 60

George P. Chrousos, M.D. 119. Perini G.I., Kling M.A., Calogero A.E., Devinski O., Smith M.A., Chrousos G.P., Gold P.W. (1990) Effects of Carbamazepine on the Hypothalamic-pituitary-adrenal Axis: Potential Relevance of its Mechanisms of Action. In: Canger R, Sacchetti E., Perini GI, Canevini MP, (Eds.) Carbamazepine: A Bridge between Epilepsy and Psychiatric Disorders. Origgio: Ciba-Geigy Edizioni, 119-123. 120. Chrousos G.P. (1993) Endocrine Tumors, In: Pizzo P.A., and Poplack D.G. (Eds). Principles and Practice of Pediatric Oncology, J.B. Lippincott Co., New York, 2nd Edition 889-912. 121. *Chrousos G.P., Gold P.W. (1992). The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis. JAMA 267:1244-1252. 122. Chrousos G.P. (1992) Regulation and Dysregulation of the Hypothalamic-pituitary-adrenal Axis: The Corticotropin Releasing Hormone Perspective. Endocrinology and Metabolism Clinics of North America 21:833-858. 123. Chrousos G.P., Dorn L. (1993) Puberty, Adolescence, and the Stress Response. In: Frajese G., Steinberger E. and Rodriguez R. (Eds) Reproductive Medicine. Serono Symposia Series, Raven Press, New York pp. 53-62. 124. Karl M., Chrousos G.P. (1993) Familial Glucocorticoid Resistance: An overview. Exp. Clin. Endocrinol. 101:30-35. 125. *Sternberg E.M, Chrousos G.P., Wilder R.L., Gold P.W. (1992) The Stress Response and the Regulation of Inflammatory Disease: NIH Combined Clinical Staff Conference. Ann. Int. Med. 117:854-866. 126. Chrousos G.P., Karl M. (1992) The Molecular Mechanisms of Glucocorticoid Resistance. In: Saez J. (Ed) Cellular and Molecular Biology of the Adrenal Cortex. John Libbey Eurotext Limited. London. Colloques INSERM 222:215-225. 127. Sharara F.I., Chrousos G.P., Patronas N. (1992) Watchful Waiting and Craniopharyngioma. (Letter to the Editor) Ann. Int. Med. 117:876-877. 128. Mastorakos G., Webster E.L., Chrousos G.P. (1993) Corticotropin-releasing Hormone and Its Receptors in the Ovary: Physiological Implications. Ann. New York Acad. Sci. 687:20-30. 129. Dorn L.D., Chrousos G.P. (1993) The Endocrinology of Stress and Stress System Disorders in Adolescence. In: R. Rosenfield (Editor) Adolescent Endocrinology. Endocrinology and Metabolism Clinics of North America 22:685-700. 130. Marini J.C., Bordenick S., Heavner G., Rose S.R., Chrousos G.P. (1993) Evaluation of the Growth Hormone Axis in Osteogenesis Imperfecta. Am. J. Med. Genet. 45:261-264. 131. Karl M., Chrousos G.P. (1995) Chapter 27, Molecular Aspects of Familial Glucocorticoid Resistance. In: B. Weintraub (Editor) Molecular Endocrinology: Basic Concepts and Clinical Correlations. Raven Press, New York, pp. 445-454. 132. *Chrousos G.P., Detera-Wadleigh S., Karl M. (1993) NIH Conference of the Combined Clinical Staff: Syndromes of Glucocorticoid Resistance. Ann. Int. Med., 119:1113-1124. 133. Chicanza I.C., Chrousos G.P., Panayi G.S. (1992) Abnormal Neurendocrine-Immune Communications in Patients with Rheumatoid Arthritis. Eur. J. Clin. Invest. 22:635-637. 134. Zeiger M.A., Pass H.I., Doppman J.D., Nieman L.K., Chrousos G.P., Cutler G.B., Jensen R.T., Norton J.A. 61

George P. Chrousos, M.D. (1992) Surgical Strategy in the Management of Non-Small Cell Ectopic Adrenocorticotropic Hormone Syndrome. Surgery 112:994-1000. 135. *Boumpas D.T., Chrousos G.P., Wilder R.L., Cupps T.R., Balow J.E. (1993) NIH Conference of the Combined Clinical Staff. Glucocorticoid Therapy of Immune-Related Diseases: Basic and Clinical Correlates. Ann. Inter. Med. 119:1198-1208. 136. *Vamvakopoulos N.C., Chrousos G.P. (1994) Hormonal Regulation of Human Corticotropin Releasing Hormone Gene Expression. Implications for the Stress Response and Immune/Inflammatory Reaction. Endocrine Reviews, 15:409-420. 137. Karl M., Accili A., Chrousos G.P. (1993) Familial Glucocorticoid Resistance and Its Molecular Basis. In: New Perspectives in Endocrinology, Serono Symposia, A. Debellis and K.B. Marschke eds., Raven Press, New York, Vol. 99, pp. 83-91. 138. Karl M., Schulte H.M., Chrousos G.P. (1994) Mutation Analysis of Steroid Hormone Receptors. In Neurobiology of Steroids, deKloet E.R. and W. Suntanto eds., Vol. of Methods in Neurosciences, Academic Press 22:226-241. 139. Friedman T.C., Chrousos G.P. (1993) Transsphenoidal Resection in Cushing's Disease: Definition of Success. (Letter to the Editor) Clinical Endocrinology, 39:701. 140. *Chrousos G.P. (1995) The Hypothalamic-Pituitary-Adrenal Axis and Immune-Mediated Inflammation. New England Journal of Medicine 332:1351-1362. 141. Margioris A., Gravanis A., Chrousos G.P. (1994) Glucocorticoids and Mineralocorticoids. Chapter 35. In: Human Pharmacology: Molecular to Clinical. T. Brody, J. Larner, K. Minneman, H.C. Neu (Eds) Mosby- Yearbook, St. Louis p. 473-481. 142. Magiakou M.A., Chrousos G.P. (1994) Corticosteroid Therapy, Nonendocrine Disease, and Corticosteroid Withdrawal. Current Therapy in Endocrinology and Metabolism. Mosby-Year Book Inc., St. Louis p.120- 124. 143. Arai K., Chrousos G.P., (1994) Glucocorticoid Resistance. Chapter 5, Baillere's Clinical Endocrinology and Metabolism. Vol. 8, No.2. Baillere Tindal London p. 317-331. 144. Arai K., Chrousos G.P., (1995) Syndromes of Glucocorticoid and Mineralocorticoid Resistance. Steroids 60:173-179. 145. Magiakou M.A., Chrousos G.P., (1996) Glucocorticoid Therapy and Withdrawal. Chapter 6 In: R.C.Bone. Current Practice of Medicine. Current Medicine, Inc., Philadelphia, IV 6.1-6.6. 146. Bamberger C.M., Chrousos G.P., (1994) Glucocorticoid Resistance. (Letter to the Editor) Annals of Internal Medicine 102:1047-1048. 147. Stratakis C.A., Mastorakos G., Chrousos G.P. (1994) Interleukin-6 Elevation in Critically Ill Infants with Sepsis and Necrotizing Enterocolitis. (Letter to the Editor) J Pediatrics 125:504. 148. Tsigos C., Chrousos G.P. (1994) Physiology of the Hypothalamic-Pituitary-Adrenal Axis in Health and Dysregulation in Psychiatric and Autoimmune Disorders. Endocrin. Metab. Clin. N. Amer. 23:451-466. 149. Chrousos G.P. (1996) Chapter 1. Organization and Integration of the Endocrine System. In: Pediatric Endocrinology, Sperling M., ed., Saunders Co.: Philadelphia, 1-14. 62

George P. Chrousos, M.D. 150. Magiakou M.A., Chrousos G.P. (1994) Diagnosis and Treatment of Cushing's Disease. In: The Pituitary Gland, H. Imura (ed), 2nd Edition, Raven Press: New York, p. 491-508. 151. Mastorakos G., Chrousos G.P (1995) Chapter 79, Adrenal Hyperandrogenism. In: Reproductive Endocrinology, Surgery, and Technology. Adashi E., Rock J., and Rosenwaks Z. eds. Raven Press, New York, p. 1539-1553. 152. Stratakis C.A., Karl M., Schulte H.M., Chrousos G.P. (1994) Glucocorticoid Resistance in Humans. Elucidation of the Molecular Mechanisms and Implications for Pathophysiology. Ann N.Y. Acad Sci 746:362-376. 153. Tsigos C., Chrousos G.P. (1995) Stress, Endocrine Manifestations and Diseases. Chapter 3. In: Handbook of Stress Medicine. Cooper C.L., ed. Boca Raton, FL: CRC Press Inc., 61-65. 154. Stratakis C.A., Gold P.W., Chrousos G.P. (1995) Neuroendocrinology of Stress: Implications for Growth and Development. Hormone Research 43:163-167. 155. Tsigos C., Chrousos G.P. (1995) Clinical Presentation, Diagnosis, and Treatment of Cushing's Syndrome. Current Opinion in Endocrinology and Diabetes, 2:203-213. 156. Papanicolaou D., Chrousos G.P. (1995) Interactions of the Endocrine and Immune Systems in Children and Young Adults. Current Opinion in Pediatrics, 7:440-444. 157. Karl M., Chrousos G.P. (1996) Experimental and Clinical Models of CRH-Induced Pituitary Tumors. In: Oncogenesis and Molecular Biology of Pituitary Tumors. S. Melmed (ed) Front. Horm. Res. Vol. 20 Karger, Basel, 54-71. 158. Tsigos C., Papanicolaou D., Chrousos G.P. (1995) Advances in the Diagnosis and Treatment of Cushing's Syndrome. Bailliere's Clinical Endocrinology and Metabolism 9:315-336. 159. Tsigos C., Arai K., Latronico A.C., Webster E., Chrousos G.P. (1995) Receptors for Melanocortin Peptides in the Hypothalamic-Pituitary-Adrenal Axis and Skin. Ann. NY Acad. Sci. 771:352-363. 160. Tsigos C., Chrousos G.P. (1995) The Neuroendocrinology of the Stress Response. Chapter 6. In: NIDA Alcohol Research Monograph: Stress, Gender, and Alcohol Seeking Behavior. W.A. Hunt and S. Zachari, ed., CSR, Inc., Washington, D.C., 29:103-124. 161. Tsigos C., Chrousos G.P. (1996) The Neuroendocrinology of Stress. In: Women, Health and Disability. D. Krotowski, M. Nosek, M. Turk (eds), Brookes Publishers, Baltimore, 203-221 162. Flack MR, Chrousos G.P. (1996) Neoplasms of the Adrenal Cortex. Chapter 101. Cancer Medicine, 4th Edition. R. Holland et al. (eds) Lea and Fibinger, New York, 1563-1570. 163. Peeke P.M., Chrousos G.P. (1995) Hypercortisolism and Obesity. Ann. NY Acad. Sci. 771:665-676. 164. Stratakis C.A., Chrousos G.P. (1995) Neuroendocrinology of Stress and the Immune Response. In: Root A., ed. Proceedings of the 1994 NCGS Investigators Meeting. Gardiner-Caldwell, Califon, NJ, p. 4-7. 165. Stratakis C.A., Vamvakopoulos NC, Chrousos G.P. (1995) Corticotropin-Releasing Hormone, Stress and Depression. In: Bailly D., ed. Neuroendocrine Aspects of Mood Disorders. Ardix Médical, Levallois p. 119-152 (in french). 166. Stratakis C.A., Chrousos, G.P. (1997) Endocrine Tumors. In: Pizzo P.A., Poplack D.G., eds. Principles and Practice of Pediatric Oncology, 3rd edition. J.B. Lippincott Raven Publishers, Philadelphia, p. 947- 63

George P. Chrousos, M.D. 976. 167. Tsigos C., Kamilaris T., Chrousos G.P. (1996) Adrenal Diseases. In: Moore W.T., Eastman R., eds. Diagnostic Endocrinology, 2nd edition. B.C. Decker Inc., Toronto, p. 123-156. 168. Tsigos C., Chrousos G.P. (1996) Differential Diagnosis and Management of Cushing's Syndrome. Ann Rev Med 47:443-61 169. Chrousos, G.P. (1995) Cytokine Therapy in Septic Shock. (Letter to the Editor) N. Engl. J. Med., 333:942- 943. 170. Bamberger C.M., Chrousos G.P. (1995) The Glucocorticoid Receptor and RU 486 in man. Ann. N.Y. Acad. Sci. 761;296-311. 171. Bamberger C.M., Bamberger A.M., Chrousos G.P. (1995) Dominant Negative Inhibitors of the Glucocorticoid Receptor. In: De Bellis A., Schipani E. (eds.) Frontiers in Endocrinology, Vol. 14. Serono Symposia Publication, Rome, Italy, pp. 129-139. 172. Stratakis C.A., Chrousos G.P. (1995) Neuroendocrinology and Pathophysiology of the Stress System. Ann. N.Y. Acad. Sci. 771:1-18. 173. Cizza G., Gold P.W., Chrousos G.P. (1995) Aging is Associated in the 344/N Fischer Rat with Decreased Stress Responsivity of Central and Peripheral Catecholaminergic Systems and Impairment of the Hypothalamic-Pituitary-Adrenal Axis. Ann. N.Y. Acad. Sci. 771:491-511. 174. Crofford L.J., Sano H., Karalis K., Webster E.A., Friedman T.C., Chrousos G.P., Wilder R.L. (1995) Local Expression of Corticotropin-Releasing Hormone in Inflammatory Arthritis. Ann. N.Y. Acad. Sci. 771:459- 471. 175. Mastorakos G., Magiakou M.A., Chrousos G.P. (1995) Effects of the Immune/Inflammatory Reaction on the Hypothalamic-Pituitary-Adrenal Axis. Ann. N.Y. Acad. Sci. 771:438-448. 176. Carter C.S., DeVries A.C., Taymans S.E., Roberts R.L., Williams J.R., Chrousos G.P. (1995) Adrenal Corticoid Hormones and the Development and Expression of Mammalian Monogamy. Ann. N.Y. Acad. Sci. 771:82-91. 177. Reincke M., Lehmann R., Karl M., Magiakou M.A., Chrousos G.P., Allolio B. (1995) Severe Illness. Neuroendocrinology. Ann. N.Y. Acad. Sci. 771:556-569. 178. *Latronico A.C., Chrousos G.P. (1997) Adrenocortical Tumors (Extensive Personal Experience Article). J. Clin. Endocrinol. Metab. 82:1317-1324. 179. Gold P.W., Licinio J., Wong M.L., Chrousos G.P. (1995) Corticotropin Releasing Hormone in the Pathophysiology of Melancholic and Atypical Depression and in the Mechanism of Action of Antidepressant Drugs. Ann. N.Y. Acad. Sci. 771:716-729. 180. Marini J.C., Bordenick S., Chrousos G.P. (1995) Endocrine Aspects of Growth Deficiency in OI. Connective Tissue Research 31:S55-S57. 181. Masi A, Chrousos G.P. (1996) The Hypothalamic-Pituitary-Adrenal-Glucocorticoid Axis in Rheumatoid Arthritis. (Editorial) J. Rheumatol. 23:577-581. 182. Chrousos G.P., Castro M., Leung D.Y.M., Webster E., Kino T., Bamberger C., Elliot S., Stratakis C., Karl M. (1996) Molecular Mechanisms of Glucocorticoid Resistance/Hypersensitivity. Am. J. Resp. Crit. Care 64

George P. Chrousos, M.D. Med. 154:S39-S44. 183. *Bamberger C.M., Schulte H.M., Chrousos G.P.. (1996) Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity. Endo. Rev. 17:221-244. 184. Torpy D.J., Chrousos G.P. (1996) The Three-Way Interactions Between the Hypothalamic-Pituitary- Adrenal and Gonadal Axes and the Immune System. Ballière's Clinical Rheumatology 10:181-198. 185. Masi A.T., Chrousos G.P. (1997) Dilemmas of Low-Dosage Glucocorticoid Therapy in Rheumatoid Arthritis: Considerations of Timing. (Leader) Annals of Rheumatic Diseases 56:1-4. 186. Cizza G., Gold P.W., Chrousos G.P. (1997) High-Dose Transdermal Estrogen, Corticotropin- Releasing Hormone and Postnatal Depression (Letter to the Editor). J. Clin. Endocrinol. Metab. 82:704. 187. Cizza G., Chrousos G.P. (1997) Anxiety and Short Stature (Letter to Editor). Pediatrics 99:500. 188. Gold P.W., Wong M-L, Chrousos G.P., Licinio J. (1996) Stress System Abnormalities in Melancholic and Atypical Depression: Molecular, Pathophysiological, and Therapeutic Implications (Editorial). Mol. Psychiatry 1:257-264. 189. Cizza G., Chrousos G.P. (1997) Adrenocorticotropic Hormone-Dependent Cushing's Syndrome: Chapter 2. Endocrine Neoplasms, Andrew Arnold, Ed. Klawer Academic Publishers, Boston, pp. 25-40. 190. Latronico A.C., Chrousos G.P. (1997) Neoplasms of the Adrenal Cortex. Chapter 11. In: Endocrine Neoplasms, Andrew Arnold, Ed., Klawer Academic Publishers, Boston, pp. 217-237. 191. Torpy D., Papanicolaou D., Chrousos G.P. (1997) Sexual Dimorphism of the Human Stress Response May Be Due to Estradiol-mediated Stimulation of Hypothalamic Corticotropin-Releasing Hormone Synthesis. (Letter to the Editor) J. Clin. Endocrinol. Metab. 82:982. 192. Dorn L., Chrousos G.P. (1997) The Neurobiology of Stress: Understanding Regulation of Affect During Female Biological Transitions. Seminars in Reproductive Medicine 15:29-45. 193. Stratakis C.A., Chrousos G.P. (1997) The Familial Lentiginosis Syndromes: Link to Inherited Neoplasias and Identification of a Genetic locus. Hellenic Medical Journal 1:15-19. 194. Chrousos G.P. (1997) The Neuroendocrinology of Stress: Its Relation to the Hormonal Milieu, Growth, and Development. Growth, Genetics & Hormones 13:1-8. 195. Stratakis C.A., Chrousos G.P. (1997) Chapter 13. Hypothalamic Hormones: GnRH, TRH, GHRH, SRIF, CRH, and Dopamine. Endocrinology: Basic and Clinical Principles, Conn P.M. and Melmed S. (Eds.), Humana Press, Totowa, NJ. 185-209. 196. Magiakou M.A., Chrousos G.P. (1997) Corticosteroid Therapy, Nonendocrine Disease, and Corticosteroid Withdrawal. Current Therapy in Endocrinology and Metabolism, Sixth Edition, Bardin C.W. (Editor), Mosby, St. Louis, MO 138-142 197. De Castro M., Chrousos G.P. (1997) Glucocorticoid Resistance. Current Therapy in Endocrinology and Metabolism, Sixth Edition, Bardin C.W. (Editor), Mosby, St. Louis, MO 188-189. 198. Torpy D.J., Chrousos G.P. (1997) General Adaptation Syndrome: An Overview. Endocrinology of Critical Disease, Ober K.P. (Editor), Human Press, Totowa, NJ 1-24. 199. Chrousos G.P. (1997) The Future of Pediatric and Adolescent Endocrinology. Ann. New York Acad. Sci., 65

George P. Chrousos, M.D. 816:4-8. 200. Mastorakos G., Ghizzoni L., Webster E.L., Chrousos G.P. (1997) Autocrine-Paracrine Role of Ovarian Corticotropin-Releasing Hormone. Ann. New York Acad. Sci., 816:22-26. 201. Magiakou M.A., Mastorakos G., Webster E., Chrousos G.P. (1997) The Hypothalamic-Pituitary- Adrenal Axis and the Female Reproductive System. Ann. New York Acad. Sci., 816: 27-41. 202. Magiakou M.A., Mastorakos G., Chrousos G.P. (1997) Cushing Syndrome: Differential Diagnosis and Treatment. Wierman M.E. (Editor), Diseases of the Pituitary: Diagnosis and Treatment, Humana Press, Totowa, NJ 179-202. 203. *Clauw D.J., Chrousos G.P. (1997) Chronic Pain and Fatigue Syndromes: Overlapping Clinical and Neuroendocrine Features and Potential Pathogenic Mechanisms. NeuroImmunoModulation 4:134-153. 204. *Papanicolaou D.A., Wilder R.L., Manolagas S.C., Chrousos G.P. (1998) The Pathophysiologic Roles of Interleukin-6 in Humans. Ann. Intern. Med. 128:127-137. 205. Chrousos G.P. (1997) Adrenal Hyperandrogenism. In: Up-to-date in Endocrinology and Diabetes (CD ROM). Editor-in-Chief, Burton D. Rose. Endocrine Society, Bethesda, MD. 206. Licinio J., Gold P.W., Chrousos G.P., Sternberg E.M. (1997) Forty Years of Neuroendocrinology (Editorial). Mol. Psychiatry 2:347-349. 207. Webster E.L., Elenkov I.J., Chrousos G.P. (1997) The Role of Corticotropin-Releasing Hormone in Neuroendocrine-Immune Interactions. Mol. Psychiatry 2:368-372. 208. Chrousos G.P. (1997) Stress as a Medical and Scientific Idea and Its Implications. Advances in Pharmacology 42:552-556. 209. Chrousos G.P. (1997) Secondary Adrenal Insufficiency. In: The Diagnosis and Treatment of Pituitary Insufficiency, S.W.J. Lamberts (Editor), Bioscientifica, Bristol, UK 39-61. 210. Pillemer S.R., Bradley L.A., Crofford L.J., Moldofsky H., Chrousos G.P. (1997) The Neuroscience and Endocrinology of Fibromyalgia. Arthritis & Rheumatism 40:1928-1939. 211. Stratakis C.A., Chrousos G.P. (1997) The Case of Urinary Growth Hormone (Editorial). Endocrine Practice 3:389-391. 212. *Torpy D.J., Chrousos G.P. (1997) Stress and Critical Illness: the Integrated Immune/Hypothalamic- Pituitary-Adrenal Axis Response. J. Intensive Care Med. 12:225-238. 213. *Chrousos G.P. (1998) Ultradian, Circadian and Stress-Related Hypothalamic-Pituitary-Adrenal Axis Activity: A Dynamic Digital-to-Analog Modulation (Editorial). Endocrinology 139:437-440. 214. *Chrousos G.P., Torpy D., Gold P.W. (1998) Interactions Between the Hypothalamic-Pituitary- Adrenal Axis and the Female Reproductive System:Clinical Implications. Ann. Intern. Med. 129:229-240. 215. Bornstein S.R., Torpy D.J., Chrousos G.P., Licinio J., Engelmann L. (1997) Leptin Levels are Elevated Despite Low Thyroid Hormone Levels in the “Euthyroid Sick” Syndrome (Letter to the Editor). J. Clin. Endocrinol. Metab. 82:4278-4279. 216. Chrousos G.P. (1998) Stressors, Stress and Neuroendocrine Integration of the Adaptive Response: 1997 Hans Selye Memorial Lecture. Ann. NY Acad. Sci. 851:311-335. 66

George P. Chrousos, M.D. 217. Shupnik M.A., Chrousos G.P., Siragy H.M. (1997) Glucocorticoids and Mineralocorticoids. In: Human Pharmacology: Molecular to Clinical, Third Edition, T.M. Brody, J. Larner, K.P. Minneman (Eds), Mosby- Year Book, St. Louis, MO 485-497. 218. Tsigos C., Chrousos G.P. (1998) ACTH Resistance Syndromes. In: G Proteins, Receptors, and Disease. A.M. Spiegel (Ed), Humana Press, Totowa, NJ 261-269. 219. Stratakis C.A., Chrousos G.P. (1998) Cushing Syndrome and Cushing Disease. In: Saunders Manual of Pediatric Practice. L. Finberg (Ed), W.B. Saunders Company, Philadelphia, PA 807-809. 220. *Chrousos G.P., Gold P.W. (1998) A Healthy Body in a Healthy Mind- and Vice Versa-: The Damaging Power of “Uncontrollable” Stress (Editorial). J. Clin. Endocrinol. Metab. 83:1842-1845. 221. Chrousos G.P., Stratakis C.A. (1998) Carney Complex and the Familial Lentiginosis Syndromes: Link to Inherited Neoplasias and Developmental Disorders, and Genetic Loci. J. Intern. Med. 243:573-579. 222. Meduri G.V., Chrousos G.P. (1998) Duration of Glucocorticoid Treatment and Outcome in Sepsis: Is the Right Drug Used the Wrong Way? (Editorial). Chest . 114:355-360. 223. *Torpy D.J., Bornstein S.R., Cizza G., Chrousos G.P. (1998) The Effects of Glucocorticoids on Leptin Levels in Humans May Be Restricted to Acute Pharmacologic Dosing. (Letter to the Editor) J. Clin. Endocrinol. Metab. 83:1821-1822. 224. Webster E.L., Torpy D.J., Elenkov I.J., Chrousos G.P. (1998) Corticotropin-Releasing Hormone and Inflammation. Ann. NY Acad. Sci. 840:21-32. 225. Leung D.Y.M., De Castro M., Szefler S.J., Chrousos G.P. (1998) Mechanisms of Glucocorticoid- Resistant Asthma. Ann. NY Acad. Sci. 840:735-746. 226. Reincke M., Arlt M., Heppner C.A., Petzke F., Chrousos G.P., Allolio B. (1998) Neuroendocrine Dysfunction in African Trypanosomiasis. Ann. NY Acad. Sci. 840:809-821. 227. *Chrousos G.P., Harris A.G. (1998) Hypothalamic-Pituitary-Adrenal Axis Suppression and Inhaled Corticosteroid Therapy. Part I. General Principles. Neuroimmunodulation 5:277-287. 228. *Chrousos G.P., Harris A.G., (1998) Hypothalamic-pituitary-adrenal Axis Suppression and Inhaled Corticosteroid Therapy. Part II. Review of the Literature. Neuroimmunodulation 5:288-308. 229. Orban Z., Bornstein S.R., Chrousos G.P. (1998) The Interaction Between Leptin and the Hypothalamic- Pituitary-Thyroid Axis. Horm. Metab. Res. 30:231-235. 230. Stratakis C.A., Chrousos G.P. (1998) Adrenal Diseases. In: Principles of Molecular Medicine, L. Jameson (Ed.), Humana Press. Totowa, NJ., p. 495-503. 231. Chrousos G.P. (1998) Neuroendocrine Alterations Associated with Altered Sleep, Mood, and Pain Perception. In: The Neuroscience and Endocrinology of Fibromyalgia, S. R. Pillemer (ed.), The Haworth Press, Inc., Binghampton, NY, p. 51-55 and. J. Musculoskeletal Pain 6:51-55, 1998. 232. Diamanti-Kandarakis E., Chrousos G.P. (1998) Cushing’s Syndrome and Androgen Excess. In: Androgen Excess Disorders in Women. R. Azziz, J.E. Nestler, D. Dewailly (eds). Lippincott-Raven Publishers, Philadelphia, p.569-584. 233. Margioris A., Chrousos G.P. (1998) Adrenal Disorders. In: Handbook of Clinical Neurology. Part II. 67

George P. Chrousos, M.D. Systemic Diseases. Vinten P.J., Bruyn G.W. (Eds.) Elsevier Science 26:205-220 234. *Gold PW, Chrousos G.P. (1999) The Endocrinology of Melancholic and Atypical Depression: Relation to Neurocircuitry and Somatic Consequences. Proc. Assn. Amer. Phys., 111:22-34 235. *Bornstein S.R., Chrousos G.P. (1999) Adrenocorticotropin ACTH- and Non-ACTH-Mediated Regulation of the Adrenal Cortex: Neural and Immune Inputs. J. Clin. Endo. Metab., 84:1729-1736. 236. Chrousos G.P. (2000)The Role of Stress and the Hypothalamic-Pituitary-Adrenal Axis in the Pathogenesis of the Metabolic Syndrome: Neuro-Endocrine and Target Tissue-related Causes (Review). Intern. J. Obesity, 24:S50-S55 237. Tsigos, C., Kyrou I, Papanicolaou D., Chrousos G.P. (1998) Prolonged Suppression of Corticosteroid- binding Globulin by Recombinant Human Interleukin-6 in Man. [Letter to the Editor]. J. Clin. Endo. Metab 83:3379. 238. Masi A.T., Chrousos G.P., Bornstein S.R. (1999) Enigmas of Adrenal Androgen and Glucocorticoid Dissociation in Premenopausal Onset Rheumatoid Arthritis. [Editorial] J. Rheumatology. 26:247-250. 239. Torpy, D.J., Stratakis, C.A., Chrousos G.P. (1999) Hyper- and Hypoaldosteronism. Vit. Horm. 57:177-216. 240. Mastorakos G., Bamberger C., Chrousos G.P. (1999) Neuroendocrine Regulation of the Immune Process. In: Plotnikoff N.P., Faith R.F., Murgo A.J., Good R.A., (Eds) Cytokines, Stress and Immunity. CRC Press Boca Raton, Fla., p.17-37. 241. *Bornstein S.R., Stratakis C.A., Chrousos G.P. (1999) Adrenocortical Tumors: Recent Advances in Basic Concepts and Clinical Management. Ann. Intern. Med. 130:759-771. 242. *Merke D.P., Bornstein S.R., Braddock D., Chrousos, G.P. (1999) Adrenal Lymphocytic Infiltration and Adrenocortical Tumors in a Patient with 21-Hydroxylase Deficiency. (Letter to the Editor) N. Engl. J. Med. 340:1121-1122. 243. Franchimont, D.P., Chrousos, G.P. (1999) Glucocorticoid Resistance and Hypersensitivity. Contemporary Endocrinology: Hormone Resistance Syndromes. (Ed. L. Jameson) Humana Press, Totowa N.J., p.259-271 244. Chrousos, G.P. (1999) Reproductive/placental corticotropin-releasing hormone and its clinical implications, Am. J. Obstetrics Gynecol. p.S249-S250. 245. Papanicolaou D., Chrousos, G. P. Cushing’s Syndrome (1999) Rakel’s Current Therapy. Editor Robert E. Rakel. W. B. Saunders Co., Philadelphia p.631-637. 246. Chrousos, G. P. , Gold, P.W. (1999) The Inhibited Child “Syndrome”. Thoughts on Its Potential Pathogenesis and Sequelae. In: Extreme Fear, Shyness and Social Phobia: Origins, Biological Mechanisms, and Clinical Outcomes, (eds.) L. A. Schmidt, J. Schulkin, Oxford Univ. Press, New York p.193-200 247. Koch, C.A., Bornstein, S.R., Pacak, K, Chrousos, G.P. (1998) How does metyrapone decrease seizures? (Letter to the Editor) Neurosurg. Rev. 21:302-303. 248. Chrousos, G. P. (1999) Glucocorticoid Therapy and Withdrawal, Current Practice of Medicine, 1:291- 296 249. *Elenkov, I.J., Chrousos, G.P. (1999) Stress Hormones, Th1/Th2-patterns, Pro/Anti- Inflammatory Cytokines and Susceptibility to Disease. Trends Endo Metab., 10:359-368 250. *Vottero, A., Chrousos, G.P. (1999) Glucocorticoid Receptor Beta: View I. Trends Endo Metab., 10:333- 68

George P. Chrousos, M.D. 338 251. Elenkov, I. J., Webster, E. L., Torpy, D. J., Chrousos, G.P. (1999) Stress, Corticotropin-Releasing Hormone, Glucocorticoids, and the Immune/Inflammatory Response: Acute and Chronic Effects. Annals NY Academy of Sciences, 876:1-13. 252. Chrousos, G.P., Elenkov, I. (2001) Interactions of the Endocrine and Immune Systems, in DeGroot L., Jameson L. (eds.) Endocrinology 4th Edition, W. B. Saunders Co., Philadelphia, Vol 1, p.571-586. 253. *Bornstein, S. R., Bottner, A., Chrousos, G.P., (1999) Editorial, Knocking Out the Stress Response. Mol Psychiatry 4 (5) :403-407. 254. Elenkov, I., Wilder, R., Chrousos, G.P., Visi, E. S., (2000) The Sympathetic Nervous System - an Integrative Interface Between Two “Supersystems”: The Brain and the Immune System, Pharmacol. Rev., 52: 595-638 255. *Lafferty, A. R., Chrousos, G.P., (1999) Pituitary Tumors in Children and Adolescents, J. Clin. Endocrinol. Metab., 84:4317-4323. 256. *Chrousos, G.P., (1999) Editorial, A New “New” Syndrome in the New World: Is Multiple Postreceptor Steroid Hormone Resistance Due to a Coregulator Defect?, J. Clin. Endocrinol. Metab., 84:4450-4453. 257. Kalantaridou S.N., Chrousos G.P. (2000) Molecular Defects Causing Ovarian Dysfunction, Ann. N.Y. Acad. of Sci. Vol. 900, 40-45. 258. Funasaka, Y., Sato, H., Chakraborty, A. K., Ohashi, A., Chrousos, G.P., Ichihashi, M., (1999) Expression Proopiomelanocortin, Corticotropin-Releasing Hormone (CRH), and CRH Receptor in Melanoma Cells, Nevus Cells, and Normal Human Melanocytes, J. Investigative Dermatology 4:105-109 259. Meyer S.E., Chrousos G. P., Gold P.W. (2001) Major Depression and the Stress System, Development and Psychopathology 13:565-580 260. *Koch, C. A., Doppman, J. L., Patronas, N. J., Nieman, L. K., Chrousos, G.P. (2000) Do Glucocorticoids Cause Spinal Epidural Lipomatosis? – When Endocrinology and Spinal Surgery Meet. Endo. Rev., 11:86- 90. 261. Chrousos G.P., (2000) Dehydroepiandrosterone and its Sulfate, Electronic Up-Date in Endocrinology, Endocrine Society, US. 262. Negrao, A.B., Deuster, P.A., Gold, P.W., Singh, A., Chrousos, G.P. (2000) Individual Reactivity and Physiology of the Stress Response. Biomed & Pharmacother 54:122-128.263. 263. Chrousos G. P., (2000) The Stress Response and Immune Function: Clinical Implications, The 1999 Novera H. Spector Lecture. Ann. New York Acad. Sci., 917:38-67. 264. Vottero A., Chrousos G.P., (1999) Glucocorticoid Receptor Isoforms Alpha and Beta: Potential Physiological and Pathological Importance, The J. of Endocrine Genetics 1: 61-71. 265. Stratakis C.A., Chrousos G.P., (1999) Adrenal Cancer, Endocrinology and Metabolism Clinics of North America, 29:15-25. 266. Elenkov, I.J. and Chrousos, G.P. (1999) Stress, cytokine patterns and susceptibility to disease. Stress and Immunity: the Neuroendocrine Link, Baillière’s Clinical Endocrinology and Metabolism 13(4): 583-595. 69

George P. Chrousos, M.D. 267. Willenberg H.S., Bornstein S.R., Chrousos G.P., (2000) Disease, Stress-Induced, Overview, Encyclopedia of Stress, Vol. 1, Academic Press, San Diego, 1:709-713. 268. Willenberg H.S., Bornstein S.R., Chrousos G.P., (2000) Adrenal Insufficiency, Encyclopedia of Stress, Academic Press, San Diego, 1:58-63. 269. Bornstein S.R., Stratakis C.A., Chrousos G.P. (2000) Cushing’s Syndrome, Medical Aspects, Encyclopedia of Stress, Vol. 1, Academic Press San Diego, 1: 615-621. 270. Koch C.A., Bornstein S.R., Chrousos G.P., Stratakis C.A. (2000) Primare pigmentierte nodulare adrenokortikale Dysplasie (PPNAD) in Rahmen des Carney-Komplexes als Ursache eines Cushing- Syndroms. Medizinische Klinik, 95:224-230. 271. Creatsas G., Mastorakos G., Chrousos G. P. (2000) Introduction: Setting Reproductive Health Priorities to Meet the Needs of the New Millennium. Ann. N.Y. Acad. Sci. 900:viii-xv. 272. Vgontzas A.N., Papanicolaou D.A., Chrousos G. P. (2000) Chronic Systemic Inflammation in Overweight and Obese Adults. (Letter to the editor) JAMA 283(17):2235-2236. 273. Chrousos G.P. and Margioris A.N.. (2000) Adrenocorticosteroids and Adrenocortical Antagonists. Ed. B. Katzung, Basic and Clinical Pharmacology, Lange, McGraw-Hill, New York, New York. 39:660-678. 274. Chrousos G.P., Zoumakis E., Gravanis A. (2000) The Gonadal Hormones and Inhibitors. Ed. B. Katzung, Lange, McGraw-Hill, New York, New York. 40:679-710. 275. Pacak, K., Chrousos, G.P., Koch, C.A., Lenders, J.W.M., Eisenhofer, G (2001). “Pheochromocytoma: Progress in Diagnosis, Therapy, and Genetics” in Margioris, A.N. and Chrousos, G.P. (Eds.) Adrenal Disorders, Humana Press: New Jersey, p. 379-414 276. *Leung, D.Y.M., Chrousos, G.P. (2000) Is there a role for glucocorticoid receptor-beta in glucocorticoid- dependent asthmatics? (Editorial) Am J Respir Crit Care Med 162:1-3. 277. Bornstein, S.R., Chrousos, G.P. (2001) Chapter 229.The Hypothalamic-Pituitary-Adrenal Axis in Stress and Critical Illness. Principles and Practice of Endocrinology and Metabolism, K. Becker (Ed.) 3rd Edition, Lippincott Williams & Wilkins Philadelphia, Pa p. 2087-2094 278. Kino, T., Vottero, A., Chrousos, G.P. (2001) “Mineralocorticoid and Glucocorticoid Receptors” in Burris, T.P. and McCabe, E.R.B. (Eds.) Nuclear Receptors and Genetic Disease, Academic Press: San Diego, p. 297-307. 279. *Chrousos, G.P. (2001) Adrenal Suppression and Clinical Glucocorticoid Deficiency in the Premature Infant: No Simple Answers (Clinical Perspective). J Clin Endocrinol Metab.86: 473-474 280. Miller, W., and Chrousos, G.P.(2001) Chapter 11: The Adrenal Cortex. Endocrinology and Metabolism, Felig P., and Frohman L. Eds., 4th Edition, McGraw-Hill, New York, NY. p387-524 281. Chrousos, G.P. (2001) Chapter 14: Glucocorticoid Therapy. Endocrinology and Metabolism, Felig P. and Frohman L., Eds. 4th Edition, McGraw-Hill, New York, NY, p 609-632 282. Chrousos G. P. (2000) Stress, Chronic Inflammation, and Emotional and Physical Well-being: Concurrent Effects and Chronic Sequelae. J. Allergy Clin. Immunol., 106: S275-S291. 283. Elenkov, I.J., Chrousos, G.P., Wilder, R.L. (2000) Neuroendocrine Regulation of IL-12 and TNF-(/IL-10 Balance. Ann. N.Y. Acad. Sciences, 917:94-105. 70

George P. Chrousos, M.D. 284. Koch, C.A., Huang, S.C., Vortmeyer, A.O., Zhuang Z., Chrousos, G.P., Pacak, K. (2000) A patient with MEN 2 and multiple mutations of RET in the germline (Letter to the editor). Experimental and Clinical Endocrinology and Diabetes, 108:493. 285. Torpy, D., Stratakis, C.A., Chrousos, G.P. (2000) Familial Hyperaldosteronism. Braz. J. Med. Biol. Res., 33:1149-1155. 286. Chikanza, I.C., Petrou, P., Chrousos, G.P. (2000) Perturbations of Arginine Vasopressin Secretion during Inflammatory Stress. Ann. New York Acad. Sci., 917:825-834. 287. *Merke, D.P., Bornstein S. R., Avila N. and Chrousos G.P. (2002) Future Directions in the Study and Management of Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency. Ann. Internal Med. 136:320-334 288. Cizza G., Ayala A., Daley M., Gold P.W., Chrousos G.P. (2001) Depression and Osteoporosis: Association or Causal Relationship? In: Physical Consequences of Depression, Ed. J. H. Thakore, Wrightson Biomedical Publishing LTD, Philadelphia, Penn 107-24. 289. *Kino T., Chrousos G.P. (2001) Glucocorticoid and Mineralocorticoid Resistance/Hypersensitivity Syndromes. J. Endocrinol. 169:437-445 290. Chrousos G. P., Kino T. (2002) Corticosteroid (Glucocorticoid) Receptor. Encyclopedia of Molecular Medicine, T. Creighton, Editor, John Wiley and Son, New York, N.Y. 916-919 291. Vottero A. and Chrousos G.P. (2004) Glucocorticoid Resistance and States. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press, 2004, San Diego, CA, USA 235-241 292. *Meyer S.E., Chrousos G.P., Gold P.W. (2001) Major Depression and the Stress System: A Lifespan Perspective. Development and Psychopathology 13: 563-578 293. *Cizza, G., Ravn, P., Chrousos, G.P., Gold, P.W. (2001) Depression: a major, unrecognized risk factor for osteoporosis? Trends Endocrinol Metab. 12(5): 198-203. 294. *Mitsiades, N., Poulaki, V., Mitsiades, C.S., Koutras, D.A., Chrousos, G.P. (2001) Apoptosis induced by FASL and TRAIL/APO2L in the pathogenesis of thyroid disease. Trends in Endocrinol. Metabolism 12:384-390 295. Bornstein S. and Chrousos, G.P., (Guest Eds. ). (2001) Adrenals. Reviews in Endocrine and Metabolic Disorders 3; Issue 3. 296. Magiakou M.A., and Chrousos G.P. (2002) Cushing Syndrome in Children and Adolescents: Current Diagnostic and Therapeutic Strategies. J. Endocrinol. Invest. 25: 181-194 297. McGriff N.,J., Csako G., Kabbani M., Diep L., Chrousos G.P. , Pucino F. (2001) Treatment Options for a Patient Experiencing Pruritic Rush Associated with Transdermal Testosterone. A Review of the Literature. Pharmacotherapy 21:1425-35 298. Joint LWPES/ESPE CAH Working Group. Concensus Statement on 21-Hydroxylase Deficiency. J. Clin. Endocrinol. Metab. 87: 4048-4053 299. Chrousos G. P., Ghizzoni L. and New M.I. (Guest Eds.) (2001) Endocrine Diseases: From Childhood to Adulthood. Special Issue: J. Endocrinol. Invest. 24 Issue 9 71

George P. Chrousos, M.D. 300. Habib K., Gold P. W., and Chrousos G.P. (2001) Neuroendocrinology of Stress. Endocrinol. Metab. Clin. NA 30: 695-728 301. *Kino T., and Chrousos G. P. (2001) Editorial. AIDS-related Insulin Resistance and Lipodystrophy: A Multifactorial Viral and Iatrogenic Condition. Endocrine Practice. 7: 479-484 302. *Koch C., and Chrousos G. P. (2001) Editorial. Is the Diminuto/Dwarf1 Gene Involved in Physiologic Adrenocortical Size Regulation and Tumor Formation? J. Clin. Endocrinol. Metab. 86: 5127-9 303. Carter C. S., Altemus M., Chrousos G.P. (2001) Neuroendocrine and Emotional Changes in the Post- partum Period. Progr. Brain Res. 133: 241-249 304. Chrousos G.P., Lafferty A., (2001) Glucocorticoid Therapy and Cushing Syndrome. eMedicine Journal 2(9) 305. Chrousos G.P., Lafferty A., (2001) Nelson Syndrome. eMedicine Journal 2(9) 306. Chrousos G.P., Lafferty A., (2001) Hyperaldosteronism. eMedicine Journal 2(9) 307. Radebold K., Koch C. A., Chrousos G.P., (2001) Multiple Endocrine Neoplasias. eMedicine Journal 2(9) 308. Koch CA, Pacak K, Chrousos GP. (2002) Chapter 37. Endocrine Tumors. In: Pizzo PA, Poplack DG (eds): Principles and Practice of Pediatric Oncology; 4th edition, Lippincott Williams & Wilkins; Philadelphia, PA; p 1115-1148 309. Koch CA, Chrousos GP. (2003) Diagnosis and Management of Cushing's Disease. In: Powell M, Lightman SL, Laws ER (eds.): Management of Pituitary Tumors: The Clinician's Practical Guide. Humana Press, Totowa, NJ; p 51-76 310. Koch CA, Huang SC, Vortmeyer AO, Chrousos GP, Pacak K, Zhuang Z. (2001) Do somatic RET mutations represent a phenomenon of tumor progression ? Curr Opin Clin Exp Res 3(3):140-145 311. *Gold PW, Chrousos GP (2002) Organization of the Stress System and Its Dysregulation in Melancholic and Atypical Depression: High vs. Low CRH/NE States. Mol. Psychiatry 7: 254-275 312. *Kino T. and Chousos GP, (2002) Editorial. Tissue-specific Glucocorticoid Resistance/Hypersensitivity Syndromes: Multifactorial States of Clinical Importance. J. Allergy Clin. Immunol. 109: 609-613 313. *Koch C. A, Chrousos GP, Chandra R, Evangelista R S, Gilbert JC, Nobuhara K, Zhuang Z, Vortmeyer AO (2002) Two-hit Model for Tumorigenesis of Nevoid Basal Cell Carcinoma (Gorlin ) Syndrome- associated Hepatic Mesenchymal Tumor. Am. J. Med Genetics 109: 74-76 314. Vgontzas AN, Vela-Bueno A, Chrousos GP (2002) Chapter 50. Endocrine Disorders and Sleep. In: Sleep Medicine, Lee-Chiong TL, Sateia MJ, Carscadon MA (Eds.) Hanley and Belfus, Inc. Philadelphia p 477- 487 315. Habib K, Gold PW, Chrousos G (2002) Hypothalamic-pituitary-adrenal Axis: Introduction to Physiology and Pathophysiology. Hormones, Brain and Behavior. 4: 841-866 316. *Vgontzas A., Chrousos GP (2002) Editorial. Sleep Disordered Breathing, Sleepiness, and Insulin Resistance: Is the Latter a Consequence, a Pathogenetic Factor or Both? Sleep Medicine 3: 389-391 317. * Kalantaridou S, Chrousos GP (2002) Clinical Review 148. Monogenic Disorders of Puberty. J. Clin. Endocrinol. Metab. 87: 2481-2494 72

George P. Chrousos, M.D. 318. Chrousos GP (2002) Chapter 264. Cushing Syndrome and Cushing Disease.In: L. Finberg and R Kleinman, Eds. Saunders Manual of Pediatric Practice 2nd Edition, WB Saunders Co.Philadelphia p909-911 319. Chrousos GP and Linder B (2002) Chapter 278. Steroid Withdrawal. In: L. Finberg and R Kleinman, Eds. Saunders Manual of Pediatric Practice 2nd Edition, WB Saunders Co. Philadelphia p950-952 320. *Tsigos C and Chrousos GP (2002) Hypothalamic-pituitary-adrenal Axis, Neuroendocrine Factors and Stress. Psychosomatic Research 53: 865-871 321. Gold PW, Gabry KE, Yasuda MR, Chrousos GP (2002) Divergent Endocrine Abnormalities in Melancholic and Atypical Depression: Clinical and Pathophysiologic Implications. Endocrinol. Metab. Clin. North America 31:37-62 322. Vgontzas AN, Chrousos GP (2002) Sleep, the Hypothalamic-pituitary-adrenal Axis, and Cytokines: Multiple Interactions and Disturbances in Sleep Disorders. Endocrinol. Metab. Clin. North America 31: 15- 36 323. Koska J, Ksinantova L, Sebokova E, Kvetnansky R, Klimes I, Chrousos G, Pacak K (2002) Endocrine Regulation of Subcutaneous Fat Metabolism during Cold Exposure in Humans. Ann. NY Acad Sci 967: 500-505 324. Chrousos G.P. (2002) Chapter 1. Organization and Integration of the Endocrine System. In: Pediatric Endocrinology, Sperling M., ed., Saunders Co.: Philadelphia, 1-14. 325. Elenkov IJ, Chrousos GP (2002) Stress Hormones, Proinflammatory and Antiinflammatory Cytokines and Autoimmunity. Ann. N Y Acad Sci 966: 290-303. 326. *Grammatopoulos D., Chrousos GP (2002) Structural and Signalling Diversity of Corticotropin-releasing Hormone (CRH) and Related Peptides and Their Receptors: Potential Clinical Applications of CRH Receptor Antagonists. Trends in Endocrinol. Metab. 13: 436-444 327. Kino T., Vottero A., Charmandari E., and Chrousos GP (2002) Familial/Sporadic Glucocorticoid Resistance Syndrome and Hypertension. Ann. NY Acad Sci. 970: 101-111 328. Alesci S., Chrousos GP, Pacak K. (2002) Genomic Medicine: Exploring the Basis of a New Approach to Endocrine Hypertension. Ann. NY Acad. Sci 970: 177-192 329. Working Group, Lawson Wilkins Pediatric Endocrine Society and European Society for Pediatric Endocrinology (2002) Concensus Statement on Congenital Adrenal Hyperplasia. J. Clin. Endocrinol. Metab. 87: 4042-4047 330. Vottero A and Chrousos GP (2002) Glucocorticoid Resistance and Hypersensitivity Syndromes. Oxford Textbook of Endocrinology and Diabetes, Eds. J. Wass and S. Shalet Oxford University Press, Oxford, p. 845-851 331. Chrousos GP (2002) The Neuroendocrinology of Stress. Clinical Endocrinology (Japan) 51:13-14 332. *Franchimont D, Kino T, Galon J, Meduri GU, Chrousos GP (2003) Glucocorticoids and Inflammation Revisited. NIH Clinical Staff Conference. NeuroImmunoModulation 10:247-260 333. *Koch C, Pacak K, Chrousos GP (2002) The Molecular Pathogenesis of Hereditary and Sporadic Adrenocortical and Adrenomedullary Tumors. J Clin Endocrinol Metab, 87: 5367-5384 73

George P. Chrousos, M.D. 334. Vgontzas A, Chrousos GP (2003) Hypothalamic-pituitary-adrenal Axis and Sleep. Chapter 31. www.Endotext.com 335. *Charmandari E, Kino T, Souvatzoglou E and Chrousos GP (2003) Pediatric Stress: Hormonal Mediators and Human Development. Hormone Res., 59: 161-179 336. *Gerrity TR, Bates J, Bell DS, Chrousos G, Furst G, Hedrick T, Hurwitz B, Kula RW, Levine SM, Moore RC, Schondorf R (2002) Chronic Fatigue Syndrome: What Role Does the Autonomic System Play in the Pathophysiology of this Complex Illness? NeuroImmunoModulation 10:134-141 337. Makrigiannakis A, Zoumakis E, Kalandaridou S, Mitsiadis N, Margioris N, Chrousos G and Gravanis A (2002) Corticotropin-releasing Hormone (CRH) and Immunotolerance of the Fetus. Bioch. Pharmacol. 7507: 917-921 338. Chrousos GP (2002) New Editor-in-Chief’s Note. NeuroImmunoModulation 10: 129-131 339. Kino T. and Chrousos GP (2002) The Hypothalamic-pituitary-adrenal Axis in AIDS. www.endotext.com 340. *Masi A and Chrousos GP (2003) Editorial: Polycystic Ovarian Syndrome and Rheumatoid Arthritis: Possible Clues to Hormonal Influences on Chronic Inflammation. Sem Arthritis and Rheumatism 33:67-71 341. Magiakou MA and Chrousos GP (2002) Glucocorticoid Therapy and Adrenal Suppression. www.endotext.com 342. Latronico AC and Chrousos GP (2002) Adrenal Cancer. Diagnosis and Treatment. www.endotext.com 343. Arai K, Shibasaki T, Chrousos GP (2002) Aldosterone Deficiency and Resistance. www.endotext.com 344. *Kino T, Mirani M, Alesci S, Chrousos GP (2003) AIDS-related Lipodystrophy/Insulin Resistance Syndrome. Horm. Metab. Res. 35: 129-136 345. *Wolak M, Chrousos GP and Gold PW (2003) Stress System: Emphasis on Corticotropin-releasing Factor in Physiologic Stress Responses and the Endocrinopathies of Melancholic and Atypical Depression. Endocrine Rev., in Press 346. Vottero A, Chrousos GP (2003) Glucocorticoid Resistance Syndromes and States. Chapter 16. www.Endotext.com 347. Kino T and Chrousos GP (2003) AIDS-related Insulin Resistance and Lipodystrophy Syndrome. Current Drug Targets- Immune, Endocrine and Metabolic Disorders 3: 111-117 348. *Hochberg Z., Pacak K., Chrousos GP (2003) Endocrine Withdrawal Syndromes. Endocrine Rev. 24: 523- 548 349. Koch C, Chrousos GP (2003) Chapter 4. Cushing Disease, In: Management of Pituitary Tumors: The Clinician’s Practical Guide. Eds M P Powell, SL Lightman and Laws ER Humana Press, Totowa NJ, 51-75 350. Charmandari E, and Chrousos GP (2003) Adrenal Insufficiency. www.endotext.com 351. Gourgiotis L and Chrousos GP (2003) Pseudo-Cushing States. www.endotext.com 352. Charmandari E, Kino T and Chrousos GP (2003) Glucocorticoids. Neonatal and Pediatric Pharmacology. Second Edition. Ed. S. Yaffe. Lippincott Williams and Wilkins, Philadelphia, Penn. p 713 (14) 74

George P. Chrousos, M.D. 353. Pedrone E, Goldman R, Calis K, Chrousos GP, Cizza G (2003) Glucocorticoid-induced Osteoporosis. www.endotext.com 354. Vgontzas A. Bixler EO, Chrousos GP (2003) Metabolic Disturbances in Obesity vs. Sleep Apnea: The Importance of Visceral Obesity and Insulin Resistance. J Intern Med. 254: 32-4 355. Arnaldi G, Angeli A, Atkinson A, Bertagna X, Cavagnini F, G. Chrousos, G. Fava A, Findling J, Gaillard RC, Grossman AB, Kola A, Lacroix A, Mancini T, Mantero F, Newell-Price J,. Nieman LK, Sonino N,. Vance ML, Giustina A and M. Boscaro (2003) Diagnosis And Complications of Cushing’s Syndrome: A Consensus Statement Journal of Clinical Endocrinology and Metabolism 88: 5593-602 356. Charmandari E. Kino T. and Chrousos GP (2004) Glucocorticoid Resistance Syndrome. eMedicine.com 357. Makrigiannakis A, Zoumakis E, Kalantaridou S, Chrousos G, Gravanis A (2003) Uterine and Embryonic Trophoblast CRH Promotes Implantation and Maintenance of Early Pregnancy. Ann NY Acad Sci. 997: 85-92 358. Kalantaridou SN, Makrigiannakis A, Mastorakos G, Chrousos GP (2003) Roles of Reproductive Corticotropin-releasing Hormone. Ann NY Acad Sci, 997: 129-135 359. Kalantaridou SN, Makrigiannakis A, Zoumakis E and Chrousos GP (2004) Reproductive Functions of Corticotropin-releasing Hormone (CRH). Research and Potential Clinical Utility of Antalarmins (CRH Receptor Type 1 Antagonists) J. Reprod Immunol 51(4): 269-74. 360. Chrousos G.P. (2004) Chapter 39. Adrenocorticosteroids and Adrenocortical Antagonists. Ed. B. Katzung, Basic and Clinical Pharmacology, Lange, McGraw-Hill, New York, New York. 641-660 361. Chrousos G.P., (2004) Chapter 40. The Gonadal Hormones and Inhibitors. Ed. B. Katzung, Lange, McGraw-Hill, New York, New York 661-692 362. Kino T., Charmandari E. and Chrousos GP (2003) Glucocorticoid Receptor. www.Endotext .com 363. Kino T., De Martino MU, Charmandari E., Mirani M, and Chrousos GP (2003) Tissue Glucocorticoid Resistance/ Hypersensitivity Syndromes. J Ster Biochem Mol Biol 85:457-467. 364. Kino T, Charmandari E, and Chrousos GP (2003) Basic and Clinical Implications of Glucocorticoid Actions. Proceedings of a Conference Dedicated to Professor Yukitaka Miyachi. Horm and Metabol Res.,35: 628-638 pr 365. Kino T, and Chrousos GP (2004) Chapter 14. Glucocorticoid and Mineralocorticoid Receptors and Associated Diseases. Essays in Biochemistry, Vol 40 : The Nuclear Receptor Superfamily. 40:137-55. 366. Baker DG, Geracioti TD, Kasckow JW, Zoumakis E, Chrousos GP (2003) Chapter 14. Cytokines and Post- traumatic Stress Disorder. In: Cytokines and Mental Health, Ed. Z. Kronfol, Kluwer Academic Publishers, Boston.301-338. 367. Charmandari E., Kino T., Chrousos G.P. Glucocorticoid Receptor.In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press 2004, San Diego, CA, USA 368. Charmandari E., Chrousos G.P. Glucocorticoids, Overview. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press 2004, San Diego, CA, USA 369. Charmandari E., Chrousos G.P. Adrenal Insufficiency. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press, 2004, San Diego, CA, USA 75-80 75

George P. Chrousos, M.D. 370. Chrousos G.P. Stress and Endocrine Physiology. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press, 2004, San Diego, CA, USA 371. Ayala A and Chrousos GP. (2004) Hypercortisolism and Cushing Syndrome. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press 2004, San Diego, CA, USA 540-548 372. Grimaldi L and Chrousos GP Metabolic and Endocrine Disorders. In Nichols D, Yaster M, Lappe DG, Haller JA and Paidas C (eds.) Golden Hour: The Handbook of Advanced Pediatric Life Support. Mosby Pub. Philadelphia (in press). 373. Kanaka-Gantenbein C, Mastorakos G and Chrousos GP (2003) Endocrine –related Causes and Consequences of Intrauterine Growth Retardation. Ann NY Acad Sci 997: 150-157 374. Chrousos G, Charmandari E, and Kino T (2004) Editorial. Networks of Glucocorticoid Actions: An Introduction to Systems Biology. J Clin Endocrinol Metab, 89: 563-564 375. Makrigiannakis A, Zoumakis E, Kalantaridou S, Chrousos G, Gravanis A (2004) Participation of Maternal and Fetal CRH in Early Phases of Human Implantation: The Role of Antalarmin. Curr Drug Targets- Imm Endo and Metab Dis 4:75-78 376. Charmandari E, Kino T and Chrousos GP (2004) Familial/Sporadic Glucocorticoid Resistance. Orphanet Encyclopedia www.orpha.net 377. Charmandari E, Kino T and Chrousos GP (2004) Glucocorticoid Actions. Orphanet Encyclopedia www.orpha.net 378. Contoreggi C, Rice KC, Chrousos GP (2004) Non-peptide Corticotropin-releasing Hormone Receptor Type 1 Antagonists and their Applications in Psychosomatic Disorders. Neuroendocrinology 80:111-123 379. Kalantaridou SN, Makrigiannakis A, Zoumakis E, Chrousos GP (2004) Reproductive Functions of Corticotropin-releasing Hormone. Research and Potential Clinical Utility of Antalarmins (CRH Receptor Type 1 Antagonists) Am J Reprod Immunol 51: 269-274 380. Chrousos G (2004) Editorial. The Glucocorticoid Receptor Gene, Longevity, and the Highly Prevalent Complex Disorders of Western Societies. Am J Medicine 117: 204-207 381. Chrousos GP (2004) Editorial. Is 11-beta- Hydroxysteroid Dehydrogenase Type 1 a Good Therapeutic Target for Blockade of Glucocorticoid Actions? Proc Ntl Acad Sci USA, 101: 6329-30 382. Magiakou MA, Chrousos G.P. Adrenal Suppression. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press, 2004, San Diego, CA, USA 81-89 383. Koch C, Chrousos G.P. Adrenal Tumors: Molecular Pathogenesis. In: Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press, 2004, San Diego, CA, USA 90-98 384. Charmandari E, Kino T, Chrousos G.P. Glucocorticoid Receptor. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press, 2004, San Diego, CA, USA 229-234 382. Charmandari E, Chrousos G.P. Glucocorticoids, Overview. In Encyclopedia of Endocrine Diseases. Luciano Martini (ed), Elsevier, Academic Press, 2004, San Diego, CA, USA 253-259 383. Alesci S, Su YA, Chrousos GP (2004) hMiDas and hMitChip (2004) New Opportunities in Mitochondrial Bioinformatics and Genomic Medicine. Eds. Long R., Antani S., Lee DJ, Nutter B, Zhang M. Proc 17 IEEE Computer-based Medical Systems, Los Alamitos, Ca p329-334 76

George P. Chrousos, M.D. 384. Tsigos C, Kyrou I and Chrousos GP (2004) Stress, Endocrine Physiology and Pathophysiology. www.Endotext.com 385. Chrousos GP (2004) Book Review. Male Hypogonadism, by Winters SG, Ed Totowa, NJ: Humana Press. Annals of Intern Medicine 140: 1064 386. Chrousos GP (2004) Book Review. Microcompetition with Foreign DNA and the Origin of Chronic Disease, by Polansky H, Ed. Center for Biology of Chronic Disease, Rochester. Neuroimmunomodulation 11: 278 387. Charmandari E, Kino T., Chrousos G. (2004) Glucocorticoids and their actions: an introduction. Ann N Y Acad Sci. 1024:1-8. 388. Charmandari E, Kino T., Chrousos G. (2004) Familial/sporadic glucocorticoid resistance: clinical phenotype and molecular mechanisms. Ann N Y Acad Sci. 1024:168-81. 389. Kino T, Chrousos G. (2004) Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? Ann N Y Acad Sci. 1024:153-67. 390. DeMartino MU, Alesci S, Chrousos GP (2004) Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism. Ann N Y Acad Sci. 1024:72-85. 391. Kino T and Chrousos GP (2004) Glucocorticoid and mineralocorticoid receptors and associated diseases. Essays Biochem. 40:137-155. 392. *Vgontzas AN, Bixler EO, Lin H-M, Prolo P, Trakada G, Chrousos G (2005) Interleukin-6 and Its Circadian Secretion in Humans. Neuroimmunomodulation 2005;12(3):131-140 393. Kalantaridou SN, Makrigiannakis A, Zoumakis E, Chrousos GP. (2004) Stress and the female reproductive system. J Reprod Immunol. 62:61-8. 394. Makrigiannakis A, Zoumakis E, Kalantaridou S, Chrousos G. (2004) Endometrial and placental CRH as regulators of human embryo implantation. J Reprod Immunol. 62:53-9. 395. *Kanaka-Gantenbein C, Fryssira H, Chrousos G, Mastorakos G (2004) Growth hormone deficiency in a case of cerebrofaciothoracic syndrome in one of two affected siblings. Am J Med Genet;129A:330. 396. Costello RB and Chrousos GP (2005) Other Bioactive Food Components and Dietary Supplements. Report to the Institute of Medicine, Natl Acad Sci US, pp 462. 397. Charmandari E, Kino T, Chrousos GP (2004) Chapter 49. Glucocorticoids,.In: Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice. Eds. Yaffe S and Aranda J. Lippincott, Williams and Wilkins Co,Philadelphia Pa 713-726 398. Weiss LM, Bertagna X, Chrousos GP et al. (2004) Adrenal Cortical Carcinoma, In: Tumors of Endocrine Origin, Pathology and Genetics, WHO Organization and Classification of Tumors, Eds. DeLellis, Lloyd RV and Heitz PU and Eng C IARC Press, Lyon 139-142 399. Sasano H, Young WF, Jr,, Chrousos GP et al. (2004) Adrenal Cortical Adenoma , In: Tumors of Endocrine Origin, Pathology and Genetics, WHO Organization and Classification of Tumors, Eds. DeLellis, Lloyd RV and Heitz PU and Eng C IARC Press, Lyon 143-146 400. *Linos D, Kiriakopoulos AC, Tsakayannis DE, Theodoridou M, Chrousos G .(2004) Laparoscopic excision of bilateral primary adrenal leiomyosarcomas in a 14-year-old girl with acquired immunodeficiency 77

George P. Chrousos, M.D. syndrome (AIDS), Surgery 136(5):1098-100. 401. Tsigos C., Kyrou I, Chrousos G.P. (2005) Stress, Endocrine Manifestations and Diseases. Chapter 6. In: Handbook of Stress Medicine and Health. Second Edition, Cooper C.L., ed. Boca Raton, FL: CRC Press Inc., 109-129. 402. Vgontzas AN, Bixler EO and Chrousos GP (2005) Sleep Apnea Is A Manifestation of the Metabolic Syndrome. Sleep Medicine Reviews. 9(3):211-24. 403. *Charmandari E, Chrousos GP, Merke D (2005) Adrenocorticotropin Hypersecretion and Pituitary Microadenoma Following Bilateral Adrenalectomy in a Patient with Classic 21-Hydroxylase Deficiency. J Pediatr. Endocrinol. 18(1):97-101. 404. *Charmandari E, Tsigos C, Chrousos GP (2005) Neuroendocrinology of Stress. Ann Rev Physiol. Vol. 67: 259-284 405. *Chrousos G, Kino T (2005) Ikaros Trancription Factors: Flying between Stress and Inflammation. J Clin Invest. 115:844-848 406. *Alesci S, De Martino MU, Ilias I, Gold PW, Chrousos GP. (2005) Glucocorticoid-induced osteoporosis: from basic mechanisms to clinical aspects. Neuroimmunomodulation 12(1):1-19. 407. Ayala A, Chrousos G (2005) Cushing’s Syndrome. In: Adrenal Glands: Diagnostic Aspects and Surgical Therapy. Eds. D. Linos and J. van Heerden. Springer-Verlag, Berlin, New York p57-66 408. Charmandari E, Chrousos G and Merke D(2005) Classic Congenital Adrenal Hyperplasia. In: Adrenal Glands: Diagnostic Aspects and Surgical Therapy. Eds. D. Linos and J. van Heerden. Springer-Verlag, Berlin, New York p101-114 409. Chrousos GP and Makrigiannakis A (2005) Guest Editors. 39th Annual Meeting of the European Society of Clinical Investigation. Eur J Clin Invest 35 (Suppl 2): 1-94 410. Kino T and Chrousos G (2005) Glucocorticoid Effects on Gene Expression. In: Handbook on Stress and the Brain. Vol 15. Eds. Stechler T, Kalin NH and Reul JMHM. p 295- 311 411. Vgontzas AN, Pejovic S and Chrousos GP (2005) Endocrine and Metabolic Disorders and Sleep. Encyclopedia of Sleep Medicine, Ed. Teofilo Lee-Chiong. John Wiley&Sons, Inc. 412. Siragy HM, Chrousos GP and Shupnik MA (2005) Chapter 33. Glucocorticoids and Mineralocorticoids.In: Brody’s Clinical Pharmacology. Molecular to Clinical. 4th Edition. Eds: KP Minneman, L Wecker. Elsevier-Mosby p 409-421 413. *Chrousos GP and Kino T (2005) Interactive Functional Specificity of the Stress and Immune Responses: The Ying, the Yang and the Defense Against Two Major Classes of Bacteria. J Infectious Dis. 192: 551- 555 414. Vgontzas AN, Bixler EO, Chrousos GP. Sleep apnea is a manifestation of the metabolic syndrome. Sleep Med Rev. 2005 Jun; 9(3):211-24. 415. Magiakou MA, and Chrousos GP (2005) Chapter 4.Biological Basis of Stress-related Diseases. In: Research Companion to Organizational Health Psychology. Eds. AS Antoniou and CL Cooper. EE Publishing, Cheltenham UK p70-86 416. *Papadimitriou A, and Chrousos GP (2005) Reconsidering the Sex Diffrences in the Incidence of Pubertal 78

George P. Chrousos, M.D. Disorders. Horm Metab Res 37:708-710 417. Chrousos GP and Kino T (2005) Glucocorticoid Action Networks and Systemic Complex Diseases. In: Hormones, Age and Cancer. Berstein L (ed) Nauka Publ Co. St. Petersburg p.226-236 418. Stratakis C and Chrousos GP (2005) Hypothalamic Hormones, In: Endocrinology: Basic and Clinical Principles, Second Edition, Eds. S Melmed and PM Conn. Humana Press, Totowa NJ , p.173-195 419. *Meduri GU and Chrousos GP (2006) Effectiveness of Prolonged Glucocorticoid Treatment in ARDS: The Right Drug the Right Way? Crit Care Med. 34(1):236-238 420. *Chrousos GP and Kino T (2005) Intracellular Glucocorticoid Signaling: A Formerly Simple System Turns Stochastic. Perspective, Science: Signal Transduction Knowledge Environment (STKE). 304: pe48 421. *Elenkov IJ, Iezzoni DG, Daly A, Harris AG, Chrousos GP (2005) Cytokine Dysregulation, Inflammation and Well-being. Neuroimmunomodulation 12:255-269 422. *Chrousos G P, Kaltsas G (2005) How Accurate Are Currently Used Methods of Determining Glycemia in Critically Ill Patients and Do They Affect Their Clinical Course? Crit Care Med. 33:2849-51 423. *Chrousos GP, Kaltsas G. (2005) Post-SARS Sickness Syndrome Manifestations and Endocrinopathy: how, why, and so what? Clin Endocrinol (Oxf). 63(4):363-5. 424. *Macrigiannakis A, Kalantaridou S, Minas V, Nikas G, Chrousos GP (2006) Hormonal and Cytokine Regulation of Early Implantation. Trends Endocrinol Metab. 17(3):101-9 425. *Kalantaridou SN, Naka KK, Bechlioulis A, Makrigiannakis A, Michalis L and Chrousos GP (2006) Premature Ovarian Failure, Endothelial Dysfunction and Estrogen/Progestogen Replacement. Trends Endocrinol Metab. 17(5):178-85. 426. *Kalantaridou SN, Makrigiannakis A, Zoumakis E and Chrousos GP (2007) Peripheral Corticotropin- releasing Hormone Is Produced in the Immune and Reproductive Systems: Actions, Potential Roles and Clinical Implications. Front Bioscience 12:572-80 427. *Pervanidou P, Kanaka-Gantenbein C and Chrousos GP (2006) Assessment of Metabolic Profile in a Clinical Setting. Curr Opinion in Clinical Nutrition and Metabolic Care 9(5):589-595 428. Zoumakis E, Grammatopoulos D and Chrousos G (2006) Corticotropin-releasing Hormone Antagonists. Eur J Endocrinol 155 (Suppl1) S85-S90 429. Chrousos GP and Kaltsas GA (2006) Chapter 16. The Stress System and the Hypothalamic-pituitary- adrenal Axis in Rheumatoid Arthritis. In: Rheumatoid Arthritis, 2nd edition, Firestein GS, Panayi GS, and Wollstein FA. Oxford University Press p221-228 430. Magiakou MA, Smyrnaki P, Chrousos GP. (2006) Hypertension in Cushing's syndrome. Best Pract Res Clin Endocrinol Metab. 20:467-82 431. Kino T, Chrousos GP (2005) Steroid Hormone Receptor Defects, Molecular Basis.Encyclopedic Reference of Genomics and Proteomics. Springer-Verlag p 1802-1807 On line www.springerlink.com 432. *Giannoulia-Karantana A, Vlachou A, Polychronopoulou S, Papassotiriou I, Chrousos GP. (2006) Melatonin and Immunomodulation: Connections and Potential Clinical Applications: Neuroimmunomodulation. Nov 21; 13(3):63-74 79

George P. Chrousos, M.D. 433. Charmandari E and Chrousos GP (2006) Metabolic Syndrome Manifestations in Classic Congenital Adrenal Hyperplasia: Do they Predispose to Cardiovascular Atherosclerotic Disease and Secondary Polycystic Ovary Syndrome? Ann NYAcad Sci 1083: 37-53 434. *Kalantaridou S, Makrigiannakis A, Zoumakis E, Chrousos GP. (2007) Peripheral Corticotropin-releasing Hormone Is Produced in the Immune and Reproductive Systems: Actions, Potential roles and Clinical Implications. Front Biosci. 12:572-80. 435. *Kanaka-Gantenbein C, Fryssira H, Kakavakis K, Bouzas E, Thomaidis L, Chrousos G, Mastorakos G. (2006) Two years of growth hormone treatment in the first growth hormone deficient patient with cerebrofaciothoracic dysplasia. J Pediatr Endocrinol Metab. 19:1179-83. 436. *Chrousos GP (2007) Commentary: Is laparoscopic adrenalectomy good for all adrenal masses? Nature Clinical Practice: Endocrinology and Metabolism 3: 210-211 437. Vgontzas AN, Bixler EO, Chrousos GP. (2006) Obesity-related sleepiness and fatigue: the role of the stress system and cytokines. Ann N Y Acad Sci. 1083:329-44. 438. Zoumakis E, Rice KC, Gold PW, Chrousos GP. (2006) Potential uses of corticotropin-releasing hormone antagonists. Ann N Y Acad Sci.1083: 239-51. 439. Kyrou I, Chrousos GP, Tsigos C. (2006) Stress, visceral obesity, and metabolic complications. Ann N Y Acad Sci.1083: 77-110. 440. *Kino T and Chrousos GP (2007) Virus-mediated Modulation of the Host Endocrine Signaling Systems: Clinical Implications. Trends Endocrinol Metab. 18: 159-166 441. Creatsas G, Mastorakos, Chrousos GP (2006) Foreword: Women's Health: The World's Safeguard. Ann NY Acad Sci 1092: xiii–xv. 442. Elenkov IJ, Chrousos GP. (2006) Stress system - organization, physiology and immunoregulation. Neuroimmunomodulation. 2006; 13 (5-6):257-67. Epub 2007 443. Kaltsas G and Chrousos GP (2007) The Neuroendocrinology of Stress. In: Handbook of Psychophysiology Eds. Cacioppo J, Tassinary, and Berntson GG, Cambridge University Press, Cambridge p 303-318 444. *Manoli I, Alesci S, Blackman MR, Su YA, Rennert OM and Chrousos GP (2007) Mitochondria as Critical Components of the Stress Response. Trends Endocrinol. Metab. 445. *Kanaka-Gantenbein C, Papandreou E, Stefanaki K, Fryssira H, Kolialexi A, Sophocleous C, Mavrou A, Kitsiou-Tzeli S, Chrousos GP. (2007) Spontaneous Ovulation in a True Hermaphrodite with Normal Male Phenotype and a Rare 46,XX/47,XXY Klinefelter's Mosaic Karyotype. Horm Res 26; 68 (3):139-144 447. Willenberg HS, S. R. Bornstein and Chrousos G. P. (2007) Adrenal Insufficiency, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 1, p 47-52 448. Pervanidou P and Chrousos G. P. (2007) Brain Natriuretic Peptide (BNP), In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol 1, p 357-360 449. Chrousos GP and Kaltsas G. (2007) Cardiovascular Disease, Stress In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 1, p 410-416 450. Bornstein SR, M. Gruber,H. S. Willenberg, C. A. Stratakis and Chrousos G. P. (2007) Cushing’s Syndrome, Medical Aspects, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, 80

George P. Chrousos, M.D. Oxford, UK, and San Diego, Vol. 1, p 682-688 451. Willenberg HS, S. R. Bornstein and Chrousos G. P. (2007) Disease, Stress Induced, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 1, p 824-828 452. Makrigiannakis A, G. Petsas and Chrousos G. P. (2007) Eclampsia and Pre-Eclampsia, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 1, p 880-884 453. Kalantaridou SN, T. Vrekoussis, A. Makrigiannakis and Chrousos G. P. (2007) Endometriosis, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego,Vol. 1, p 927- 931 454. Eleftheriades M, P. Pervanidou and Chrousos G. P. (2007) Fetal Stress, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 2, p 46-51 455. Alevizaki M and Chrousos G. P. (2007) Heart Failure, Stress Effects, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 2, p 272-274 456. Manoli I, S. Alesci and Chrousos G. P. (2007) Mitochondria, In: Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, Vol. 2, p 754-761 457. *Makras P, Alexandraki KI, Chrousos GP, Grossman AB, Kaltsas GA (2007) Endocrine Manifestations in Langerhans’ Cell Histiocytosis (LCH). Trends Endocrinol Metab 458. *Chrousos GP, Kino T (2007) Glucocorticoid action networks and complex psychiatric and/or somatic disorders. Stress 10:213-219 459. Kalantaridou SN, Zoumakis E, Makrigiannakis A, Godoy H, Chrousos GP. (2007) Role of Corticotropin- releasing Hormone in Blastocyst Implantation and Early Fetal Immunotolerance. Horm Metab Res. 39:474- 477. 460. Pervanidou P, Chrousos GP. (2007) Post-traumatic Stress Disorder in Children and Adolescents: From Sigmund Freud's "Trauma" to Psychopathology and the (Dys)metabolic Syndrome. Horm Metab Res. 39:413- 419 461. Meduri GU, Marik PE, Chrousos GP, Pastores SM, Arlt W, Beishuizen, Bokhari F, Zaloga G, Annane D (2007) Steroid Treatment in ARDS Network Trial and the Recent Literature. Crit Care Med. 462. Diamanti-Kandarakis E, Papavassiliou AG, Kandarakis SA, Chrousos GP. (2007) Pathophysiology and types of dyslipidemia in PCOS. Trends Endocrinol Metab. 2007 Aug 8; [Epub ahead of print] 463. Chrousos GP (2007) Organization and Integration of the Endocrine System. The Sleep and Wakefulness Perspective. Sleep Medicine Clinics 2: 125-145 464. Trakada G, Chrousos GP, Pejovic S, Vgontzas AN (2007) Sleep Apnea and its Association with the Stress System, Inflammation, Insulin Resistance and Visceral Obesity. Sleep Med Clin 2: 251–261 465. Basta M, Chrousos G, Vela-Bueno A, Vgontzas AN (2007) Chronic Insomnia and the Stress System. Sleep Med Clin 2: 279–291 466. Zoumakis E, Kalantaridou SN, Chrousos GP (2007) The “Brain-Skin Connection”: Nerve Growth Factor- dependent Pathways for Stress-Induced Skin Disorders J Mol Med 467. Cutolo M, Straub R, Chrousos GP, Eds. (2006) Issue on Stress and Autoimmunity. Neuroimmuno- 81

George P. Chrousos, M.D. modulation 13: 253-382 468. Priftis KN, Papadimitriou A, Nicolaidou P, Chrousos GP (2007) The Hypothalamic-pituitary-adrenal axis in asthmatic children. Trends Endocrinol Metab 469. Stefanaki C, Chrousos GP, Katsambas A (2007) Glucocorticoid and sex hormone receptors: clinical implications and therapeutic relevance. Dermatol Clin. 25(4): 503-13. C. BOOKS 1. Chrousos G.P., Loriaux D.L., Lipsett M.B. (Eds) (1986) Steroid Hormone Resistance: Mechanisms and Clinical Aspects. In the Series: Advances in Experimental Medicine and Biology, Vol. 196, Plenum Press, New York, (439 pages, ISBN 0-306-42229-8). 2. D'Agata R., Chrousos G.P. (Eds) (1987) Recent Advances in Adrenal Regulation and Function. Serono Symposia Series, Vol. 40, Raven Press, New York, (311 pages, ISBN-0-8816-178-9). 3. Chrousos G.P., Loriaux D.L., Gold P.W. (Eds) (1988) Mechanisms of Physical and Emotional Stress. In the Series: Advances in Experimental Medicine and Biology, Vol. 245, Plenum Press, New York. (542 pages, ISBN-0-306-430-177). 4. Ludecke D., Chrousos G.P., Tolis G. (Eds) (1990) Cushing's Syndrome and Other Hypercortisolemic States. In the Series: Progress in Endocrine Research and Therapy, Vol. 5, Raven Press, New York (318 pages, ISBN-0-88167-718-3). 5. Tolis G., Bringer J., Chrousos G.P. (Eds.) (1993) Intraovarian Regulators and the Polycystic-Ovary Syndrome. Ann. New York Acad. Sci., Vol. 687, New York (320 pages, ISBN-089 766-779-4 and 0-89 766-780-8). 6. Chrousos G.P., McCarty R., Cizza G., Pacak K., Sternberg E., Gold P.W., Kvetnanski R. (Eds.) (1995) Stress: Mechanisms and Clinical Implications. Ann. New York Acad. Sci., Vol. 771, New York. (755 pages, ISBN 0-89766-943-6, cloth; 0-89766-944-4, paper). 7. Creatsas G., Mastorakos G., Chrousos G.P. (Eds.) (1997) Adolescent Gynecology and Endocrinology: Basic and Clinical Aspects. Ann. New York Acad. Sci., Vol. 816, New York. (470 pages, ISBN 1-57331- 038-7, cloth; 1-57331-039-5, paper). 8. McCann S., Sternberg E.M., Lipton J., Chrousos G.P., Gold P.W., Smith C. (Eds.) (1998) Neuroimmunomodulation: Molecular Aspects, Integrative Systems and Clinical Advances. Ann.N.Y. Acad. Sci. Vol. 840, New York (866 pages, ISBN 1-57331-072-7, cloth; 1-57331-073-5, paper). 9. Creatsas G., Mastorakos G., Chrousos G. P., Eds. (2000) “The Young Woman at the Rise of the 21st Century: Gynecological and Reproductive Issues in Health and Disease,” Ann. N.Y. Acad. Sci. 900: (445 pages, ISBN 1-57331-227-4). 10. Margioris, A.N. and Chrousos, G.P. (Eds.) (2001) Adrenal Disorders. Humana Press: Totowa, New Jersey, (424 pages, ISBN 0-89603-411-1). 11. Chrousos G.P. Olefsky J.M. and Samols E. (Eds.) (2002) Hormone Resistance and Hypersensitivity States. In Modern Endocrinology Series. Lippincott, Williams and Wilkins Publ. Co. Philadelphia Pa. (542 pages, ISBN 0-7817-1497-4). 82

George P. Chrousos, M.D. 12. Chrousos G.P. (Editor-in-chief) (2002-) Pediatric Endocrinology Electronic Textbook, www.eMedicine.com 13. Chrousos G.P. (Associate Editor) (2003-) Adrenal Diseases. On-line Textbook, Endocrinology and Metabolism, www.Endotext .com 14. Chrousos G.P. (Associate Editor) (2004) Adrenal Physiology and Disorders. Encyclopedia of Endocrinology and Endocrine Disorders, Elsevier, Academic Press, Oxford, UK, and San Diego, CA. ISBN 0-12-475570-4 (set of 4 volumes) 15. Creatsas G., Mastorakos G., Chrousos G. P., Eds. (2003) “Challenges on Women’s Health and Disease. Ann. N.Y. Acad. Sci. Vol. 997 (390 pages, ISBN 1-57331-458-7). 16. Geenen V. and Chrousos GP Eds. (2004) Immunoendocrinology in Health and Disease. Marcel Dekker Inc. New York (ISBN: 0-8247-5060-8). 17. Chrousos GP, Associate Editor (2007) Encyclopedia of Stress, 2nd Edition, Elsevier, Academic Press, Oxford, UK, and San Diego, CA. (set of 3 volumes, ISBN: 978-0-12-088503-9). 18. Kino T, Charmandari E, Chrousos G. Eds. (2004) Glucocorticoid Action: Basic and Clinical Implications Ann N Y Acad Sci. Vol 1024 (221 pages, ISBN: 1-57331-557-5). 19. Alesci S, Manoli I, Costello R, Oates P, Gold PW. Chrousos GP and Blackman M (Eds.) (2004) Carnitine: The Science behind a Conditionally Essential Nutrient. Ann NY Acad Sci. Vol 1033 (199 pages, ISBN: 1- 57331-555 -9) 20. Chrousos GP; Tsigos C (Eds.) (2006) Stress, Obesity, and Metabolic Syndrome. Ann NY Acad Sci. Vol 1083 (345 pages, ISBN: 1-57331-625-3) 21. Chrousos GP, Kaltsas GA, Mastorakos G (2006) Neuroendocrine and Immune Crosstalk. Ann NY Acad Sci. Vol 1088, published Nov 2006 (412 pages, ISBN: 1-57331-623-7) 22. Creatsas G, Mastorakos, Chrousos GP (2006) Women's Health and Disease: Gynecologic, Endocrine, and Reproductive Issues. Ann NY Acad Sci. Vol 1092 (482 pages, ISBN: 0077-8923) 23. Pandi-Perumal SR, Cardinali DP, Chrousos GP (2007) Neuroimmunology of Sleep. Springer Corp. ( 361 pages, ISBN: 0-387-69144-8) 83

George P. Chrousos, MD

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