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Developmental Origin..

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  • 1. FOR WEBSITE-- TO BE USED AS A LINK FOR THE PEDIATRIC DEPARTMENT AND ANY OTHER LAB THAT WISHES IT SO. Developmental Origins of Endocrine Dysfunction Overview A Picture Here—someone talking The goal of this N.I.H. supported Training Program is to provide high with a trainee while discussion quality research training in one of two major tracks, Basic Science or data or at a poster session---Do Clinical Investigation and Epidemiology to pediatricians and basic any of you have a picture like scientists demonstrating a career commitment to academic pediatric that? endocrinology and metabolism. This program is centered in the Division of Pediatric Endocrinology, Ddepartment of Pediatrics, Endocrine Division, but includes faculty from other departments that offer an interdisciplinary research environment for the successful training of young physician-scientist in the specific area of mechanisms playing a role in the impact of early life events on endocrine disorders in post-natal life. The program can also support candidates with a Ph.D. degree seeking further training in endocrinology in a developmental context. This training grant is a key aspect of the Pediatric Endocrine Subspecialty Training Program. The Highlights of this Training Program Include: • Research that uses clinical, cellular/molecular, physiological, and/or behavioral approaches to tackle integrated questions. • Research Mentors with expertise in a variety of problems and approaches that come from many departments. • Increasing the breadth of training by including intellectual and technical training from two mentors that represent the basic and clinical links to the chosen project. • Coursework tailored to the individualized training needs of the trainee. For more information, contact the Director or Associate Director of the Training Grant. Director: Associate Director: Delia M. Vazquez, M.D. Vasantha Padmanabham, Ph.D. Associate Professor and Pediatric Endocrine Professor and Director of Pediatric Fellowship Director Endocrine Research dmvazq@umich.edu vasantha@umich.edu
  • 2. Pediatric Endocrinology Training Program Faculty: Rank, Research Interest and Role MENTOR AND RESEARCH TRACK RANK RESEARCH INTEREST Christin Carter-Su, PhD Professor, Molecular and Growth/Diabetes: Growth hormone Basic Science Track Integrative Physiology receptor structure and signal transduction pathways William Herman, MD Professor, Internal Medicine, Diabetes: Diabetes, diabetes Basic Science Track Endocrinology and complications, diabetes and Clinical Investigation Track Epidemiology, Interim pregnancy, diabetes epidemiology, Director, Michigan Diabetes managed care and health economics Research and Training Center Jeff Horowitz, PhD Assistant Professor, Division Obesity/Diabetes/Energy Basic Science Track of Kinesiology Metabolism: regulation of fat and carbohydrate metabolism Josephine Kasa-Vubu, MS, MD Assistant Professor, Obesity/Reproduction: Hormonal Clinical Investigation Track Department of Pediatrics & regulation and insulin resistance in Comm Diseases, Pediatric adolescent girls. Endocrine Division Theresa Lee, PhD Professor, Psychology & Behavior/Reproduction/Stress: Basic Science Track Neuroscience Regulation of adult sex behavior by prenatal exposure to excess sex steroids Ram Menon, MD Professor, Pediatrics & Comm Growth/Diabetes/Reproduction: Basic Science Track Diseases & Physiology, Growth hormone action, regulation of Director, Pediatric Endocrine gene transcription, and role of growth Division and Molecular & factors in germ cell function. Integrative Physiology Martin Myers Jr., MD, Ph.D. Assistant Professor Obesity/Diabetes: Basic Science Track Internal Medicine and Type 2 diabetes, energy balance, Physiology insulin, leptin Vasantha Padmanabhan, PhD Professor, Pediatrics & Comm Reproduction/Growth: Diseases, Obstetrics and Understanding the fetal origin of Basic Science Track Gynecology, and Molecular & pubertal and adult reproductive and Clinical Investigation Track Integrative Physiology metabolic disorders and the impact of native steroids and estrogenic environmental pollutants in programming such defects. Jessica Schwartz, PhD Professor, Molecular and Growth: Mechanisms for regulation Basic Science Track Integrative Physiology; of gene expression by growth factors Director, Cellular and Molecular Biology Training Program Robert Thompson, PhD Assistant Professor, Obesity/Reproduction: Modulation Basic Science Track Psychiatry and Reproductive of processes leading to successful Science and unsuccessful reproduction, regulation lipid metabolism. Delia M. Vazquez, MD Associate Professor, Stress/Growth/Behavior: Molecular Basic Science Track Pediatrics & Comm Diseases, brain mechanisms underlying long- Clinical Investigation Track Pediatric Endocrinology term consequences of stress in Division, and Psychiatry; growing organisms & Consequences Research Associate of prenatal and postnatal stress in Professor, Center for Human infants and children Growth and Development
  • 3. Jon Kar Zubieta, MD, PhD Associate Professor, Stress Regulatory Mechanisms Clinical Investigation Track Departments of Psychiatry, Examination of neurotransmitter Radiology and Mental Health systems and neuronal nuclei involved Research Institute in the stress response and emotional regulation in humans with PET and fMRI
  • 4. The Department of Pediatrics Division of Endocrinology provides an exciting and vigorous research setting for faculty to perform the most advanced research aimed at understanding the pathophysiology of pubertal and adult endocrine, behavioral, growth and reproductive disorders. The Faculty employ a wide array of integrative molecular, cellular, physiologic and clinical approaches to explore fundamental questions relating to growth and differentiation of tissues and the genes and signaling pathways involved in organ function and dysfunction. Both animal and clinical models are effectively employed to gain an understanding of the origin and pathophysiology of pediatric and adult endocrine diseases and develop strategies to prevent or manage diseases. Faculty with both basic and clinical science research interests interact amongst themselves and with various members of the University faculty to provide exciting preclinical, translational and clinical research opportunities. An NIH funded Postdoctoral Research Training Program in Pediatric Endocrinology and Diabetes supported by 10 established investigators from 9 different departments at the University of Michigan facilitates high quality research training for both pediatricians and basic scientists demonstrating a career commitment to academic pediatric endocrinology and metabolism. The individual pediatric endocrinology faculty and their research areas are: Department’s Web site
  • 5. Delia M. Vazquez, M.D. Developmental Origins of Endocrine Dysfunction A Ppostdoctoral positions are is available to study mechanisms leading to Developmental Origins of Endocrine Dysfunction. The candidate can choose among several targeted areas of pediatric endocrine research – growth, metabolic syndrome, reproduction, and stress and behavior. Each research area is sponsored by one of 10 established investigators from 9 different departments at the University of Michigan who are exploring possible mechanisms of endocrine dysfunction at a cellular and molecular, physiological, behavioral and/or clinical level in a developmental context. Qualifications: Applicants must hold a Ph.D. in physiology, bioengineering, cell and molecular biology, or a related field from an accredited program. The position is funded by a recent training award from NIH-NIDDK. U.S. citizenship or permanent resident status is necessary due to training grant requirements. For further information visit our website at -------and contact individual investigators based on your research interest. Please provide a CV, three letters of reference (or contact information), and a detailed cover letter describing research experience, interests, and short and long term career goals. Post-Doctoral Opportunity Advertisement
  • 6. Another Version for Web site—which is too wordy…. Developmental Origins of Endocrine Dysfunction This new postdoctoral research training program in Pediatric Endocrinology and Diabetes at the University of Michigan has two main goals: 1) to provide high quality research training in one of two major tracks, Basic Science or Clinical Investigation and Epidemiology to pediatricians and basic scientists demonstrating a career commitment to academic pediatric endocrinology and metabolism, and 2) to provide an interdisciplinary research environment for the successful training of young physician-scientist in the specific area of mechanisms playing a role in the impact of early life events on endocrine disorders in post-natal life. The Pediatric Endocrinology Training Program (PETP) will provide 2 years of intensive postdoctoral research training for M.D. and Ph.D. trainees in an individualized and closely-mentored research training program designed to best fit each trainee’s skills and interests. For the physician-scientist, this program will be integrated with the ongoing ACGME approved fellowship program to include a one year intensive training in clinical pediatric endocrinology, which will be funded with non-NIH monies. In order to provide outstanding mentorship for the trainees, the PETP will be actively supported by 10 established investigators from 9 different departments at the University of Michigan, all with extensive research and mentoring experience within their respective areas of expertise. Each trainee will be mentored by a clinical/basic dyad of mentors to provide strong footing on hypothesis-driven translational research, centering on developmental origin of endocrine diseases. The trainee will choose among several targeted areas of pediatric endocrine research – growth, metabolic syndrome, reproduction, and stress and behavior. These areas are chosen because of the established strengths of other University of Michigan research programs and participating investigators in the PETP (see PETP Faculty, below). The overarching goal is to foster academic careers that will improve children's health and thereby, the health of the population in the United States.

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