Dermatology E. Simko WCVM PTT slides:

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Dermatology E. Simko WCVM PTT slides:

  1. 1. Dermatology E. Simko WCVM
  2. 2. PTT slides: http://duke.usask.ca/~els920/
  3. 3. References: General: Thomson's Special Veterinary Pathology W. W. Carlton et. al. Special: Muller & Kirk's Small Animal Dermatology D. W. Scott et. al Canine & Feline Dermatology G. H. Nesbitt and L. J. Ackerman Large Animal Dermatology D. W. Scott E. Simko WCVM
  4. 4. Dermis Epidermis Primary hair Secondary hair Superficial plexus Elector pili muscle Sebaceous gland Middle plexus Deep plexus Sweat gland E. Simko WCVM Anatomy Subcutis
  5. 5. Infundibulum Isthmus Inferior segment Hair bulb Dermal papilla Hair Anatomy E. Simko WCVM Hair Follicle
  6. 6. Stratum basale Basment membrane Stratum spinosum Stratum cornium Stratum granulosum Hemidesmosomes Desmosomes E. Simko WCVM Epidermis Anatomy
  7. 7. Anatomy - Epidermis E. Simko WCVM Melanocytes Langerhans cells Merkel cells Lymphocytes Immigrant Cells
  8. 8. <ul><li>Exogenous Factors: </li></ul><ul><li>Infectious </li></ul><ul><li>Nutritional </li></ul><ul><li>Allergic </li></ul><ul><li>Physical </li></ul><ul><li>Chemical </li></ul><ul><li>Endogenous Factors: </li></ul><ul><li>Immunologic </li></ul><ul><li>Hereditary </li></ul><ul><li>Congenital </li></ul><ul><li>Hormonal </li></ul><ul><li>Metabolic </li></ul><ul><li>Emotional </li></ul><ul><li>Internal dz </li></ul><ul><li>Age </li></ul>E. Simko WCVM Response to injury
  9. 9. Response to injury <ul><li>Orthokeratotic </li></ul><ul><li>Hyperkeratosis </li></ul><ul><li>Idiopathic seborrhea </li></ul><ul><li>Ichtiosis </li></ul><ul><li>Vitamin A deficiency </li></ul>Hyperkeratosis E. Simko WCVM
  10. 10. <ul><li>Zinc-responsive dermatosis </li></ul><ul><li>Hepatocutaneous syndrome </li></ul>Hyperkeratosis E. Simko WCVM Parakeratotic Hyperkeratosis Response to injury
  11. 11. Hyperplasia (Acanthosis) <ul><li>Irregular </li></ul><ul><li>Regular </li></ul><ul><li>Papillated </li></ul><ul><li>Pseudocarcinomatous </li></ul>E. Simko WCVM Response to injury
  12. 12. Response to injury - Hyperplasia Alterations in epidermal growth Pseudocarcinomatous Papillated Regular Irregular Normal Hyperplasia Atrophy/ Hypoplasia Normal Aplasia E. Simko WCVM
  13. 13. Response to injury Pigmentation Hyperpigmentation <ul><li>Endocrine diseases </li></ul><ul><li>Chronic inflammation </li></ul>E. Simko WCVM
  14. 14. Dermis Epidermis Response to injury Pigmentation Hypopigmentation <ul><li>Hereditary/Congenital </li></ul><ul><li>Aquired with pigmentary incontinence </li></ul>E. Simko WCVM
  15. 15. Apoptosis <ul><li>Physiologic </li></ul><ul><li>Pathologic </li></ul>(Programmed cell death) Necrosis cell death initiating inflammation E. Simko WCVM Response to injury
  16. 16. Epidermal Edema Intercellular (Spongiosis) Non specific inflammatory change E. Simko WCVM Response to injury
  17. 17. Epidermal Edema Intracellular Edema <ul><li>Vacuolar degeneration </li></ul><ul><li>Hydropic degeneration </li></ul><ul><li>Balooning degeneration </li></ul>E. Simko WCVM Response to injury
  18. 18. Epidermal Edema Vesicle/pustule formation (Autoimmune dz) Reticular degeneration (Viral diseases) E. Simko WCVM Response to injury
  19. 19. E. Simko WCVM Acantholysis <ul><li>Autoimmune dz </li></ul><ul><li>Pyoderma </li></ul>Response to injury Acanthocyte
  20. 20. E. Simko WCVM Epidermal inflammation <ul><li>Exocytosis </li></ul><ul><li>Pustule </li></ul><ul><li>Crust (serous hemorrhgic, cellular) </li></ul>Response to injury
  21. 21. E. Simko WCVM Dermal reaction to injury <ul><li>Atrophy </li></ul><ul><li>Inflammation and fibrosis </li></ul><ul><li>Depositions </li></ul>Response to injury
  22. 22. E. Simko WCVM Adnexal reaction to injury Atrophy <ul><li>Physiologic </li></ul><ul><li>Pathologic </li></ul>Response to injury
  23. 23. Catagen <ul><li>Controlled by: </li></ul><ul><li>daylight hours </li></ul><ul><li>environment </li></ul><ul><li>genetic factors </li></ul><ul><li>hormones </li></ul>Modified from Applied Veterinary Histology, W.J.Banks Hair Cycle Anagen Telogen
  24. 24. Modified from Applied Veterinary Histology, W.J.Banks and Small Animal Dermatology, D.W. Scott Trichography Anagen Telogen Response to injury
  25. 25. Folliculitis Superficial folliculitis Deep folliculitis <ul><li>Furunculosis </li></ul><ul><li>Adenitis </li></ul>E. Simko WCVM Response to injury

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