CURRICULUM VITAE

Wai-Nang Paul Lee

Address:
Department of Pediatric
Division of Pediatric Endocrinology
1124 W. Carson S...
Harbor-UCLA Medical Center.
2003-present   Acting Division Chief, Division of Pediatric Endocrinology

Committee Services:...
4) “UCLA Center for Dietary Supplements Research: Botanicals”, 1 P50 AT00151, Co-PI, Heber (PI),
8/1/99 – 7/31/04
5) “Pero...
16. Fymat, A.L., Greenfield, M.A. and Lee, W.N.P. Absolute radioassay of extended sources: An
    equivalent point source ...
34. Goux, W. J., A. A. D. Strong, B. L. Schneider, W-N. P. Lee, and L. J. Reitzer. Utilization of aspartate
    as a nitro...
52. Radziuk, J and W-N P Lee. [U-13C6]-glucose and the estimation of gluconeogenic rates: Closing
     remarks. Am J. Phys...
69. Marin S, Chiang K, Bassilian S, Lee WNP, Fernández-Novell JM, Medrano A, Rodriguez-Gil JE, and
    M Cascante. Metabol...
85. Xu J, Gowen L, Raphalides C, Hoyer KK, Weinger JG, Renard M, Troke JJ, Vaitheesyaran B, Lee
    WN, Saad MF, Sleeman M...
Metabolic Research. T.E. Chapman, R. Berger, D.J. Reijngoud and A. Okken, (eds), Intercept Ltd,
     Andover, Hampshire, E...
20. Maguire G, Boros LG and Lee P. Development of Tracer-Based Metabolomics and its Implications
    for the Pharmaceutica...
13. Lee WNP, Wong D and Boros LG. The Nature of Metabolomics Data. Presented at the First
    International Meeting of the...
13. Lee, W.N.P., Harpen, M.D., Siegle, J.A. and Greenfield, M.A. Application of a competitive binding
    technique for th...
29. Cooper, D.M., Barstow, T., Lee, W.N.P. and Bergner, E.A. Glucose turnover and recycling during
    exercise in normal ...
46. Katz, J., Wals P.A. and Lee, W-N.P. The application of mass isotopomer analysis to the study of
    gluconeogenesis. I...
60. Bergner, E. A. and W.-N. P. Lee. Testing GC/MS systems for linearity of response. Presented at the
    Third Internati...
75. Rajavashisth T. B., Bergner E. A., Clinton S. K., and W-N. P. Lee. Dietary Fat Intake Does Not
     Affect Cholesterol...
88. Boros, L.G., Comin, B., Puigjaner, J., Brandes, J.L., Muscarella, P., Yusuf, F., Williams, R.D., Lee,
     W.P., Casca...
103. Mao, C.S., Bassilian, S., Lim, S.K. and W.N.P. Lee. Underestimation of gluconeogenesis by the
     U13C-glucose metho...
118. Boros, L.G., Go, V.L., Lee, W-N.P. Metabolic Profiling of Cell Growth and Death in Cancer.
     Presented at the Camb...
133. Tucker C., L.G. Boros, J. Santos, S. Bassilian, J. S. Torday, W-N. P. Lee, V. Rehan. Differential
     effects of vit...
147. Garg M, M. Thamotharan, S. Thamotharan, Samuel Lee, S Bassilian, W.N. Paul Lee, SU Devaskar.
     Maturation of gluco...
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CURRICULUM VITAE Wai-Nang Paul Lee Address: Department of ...

  1. 1. CURRICULUM VITAE Wai-Nang Paul Lee Address: Department of Pediatric Division of Pediatric Endocrinology 1124 W. Carson Street Torrance, CA 90502 (310) 222-6729 Education: 1963-1966 University of California, Berkeley, B.A. in Biochemistry. 1966-1971 Stanford University, M.D. 1971-1972 Cleveland Metropolitan General Hospital, Cleveland, Ohio. Pediatric Internship. 1972-1973 Cleveland Metropolitan General Hospital-Case Western Reserve University Hospital, Cleveland, Ohio, Pediatric Residency. 1973-1974 USC-LAC Medical Center, Pediatric Pavilion, Los Angeles, California. Pediatric Residency. 1974-1976 University of California at Los Angeles, Fellowship in Pediatric Endocrinology. 1982-1986 California State University, Northridge, MBA. Honors: Phi Beta Kappa, University of California, Berkeley, California. Graduated with Honor in Biochemistry, 1966. Beta Gamma Sigma, California State University, Northridge, 1986. Licensure: 1972 - National Board of Medical Examiner. 1973 - Board of Medical Examiner, State of California, Lic. G25229. 1976 - Board Certification by the American Board of Pediatrics, Certification #19330. 1978 - Certification in Subspecialty of Pediatric Endocrinology by the American Board of Pediatrics, Certificate #121. Academic Appointment: 1976-1984 Assistant Professor of Pediatrics (UCLA). 1984-1992 Associate Professor of Pediatrics (UCLA). 1992-present Professor of Pediatrics (UCLA). Hospital Appointments: 1976-1986 Attending Staff, UCLA Hospital. 1976-1986 Attending Staff, Olive View Medical Center. 1986-1992 Associate Program Director, General Clinical Research Center 1986-present Attending Staff, Harbor-UCLA Medical Center. 1986-present Director Stable Isotope Analytical Facility, Harbor-UCLA Medical Center. 1994-1999 Pediatric Ward Director 1997-1998 Sabbatical in Residence with Dr. Jake Lusis, UCLA. 1999-2006 Vice Chair for Research, Department of Pediatrics, 1
  2. 2. Harbor-UCLA Medical Center. 2003-present Acting Division Chief, Division of Pediatric Endocrinology Committee Services: Member of General Clinical Research Center (GCRC) Advisory Committee, 1986-present. Member of Clinical Nutrition Research Unit (CNRU) Executive Committee, 1986-2007. Member of Hospital Laboratory Committee, 1994-present. (Co-Chair, 1998) Alternate Member (Department representative) of the REI Research Committee, 1998-1999 Member (Department representative) of the REI Research Committee, 1999-2006 Member of the REI Finance Committee, 1999-2000 Member of the Advisory Committee to the California State Newborn Screening for Metabolic Disease, 2002-2004. Others: Recipient of GC-MS training grant from the GCRC Branch of NIH 1978-1979. Member of Metabolism Study Section (NIH DRG) 1995 -1998 Memberships in Professional Societies: Fellow of the American Academy of Pediatrics - 1978-1995 Member of the Lawson Wilkins Pediatric Endocrine Society - 1979 - present. Member of the American Diabetic Association, 1978 - present. Member of the Western Society for Pediatric Research - 1982 - present. Member of the Endocrine Society - 1987 - present. Member of the American Institute of Nutrition and FASEB - 1992 - present. Member of the American Physiological Society - 1995 - present. Member of the American Pediatric Society 2004 to present Founding member of the Metabolomic Society, 2004 Associate Editor, Journal of Metabolomics, 2004-present Grant Supports: American Diabetes Association: 1) “Study of Precursor Product Relationship in Gluconeogenesis Using Stable Isotope Methodology in Diabetes”, July 1985-June 1986. 2) “Mass Isotopomer Study of Gluconeogenesis”, July 1992-April 1993. 3) “Role of Chain Shortening/Elongation in Energy Metabolism in Obesity and Diabetes”, July 1999– August 2000. March of Dimes: 1) “Congenital Lactic Acidosis” July 1995-June 1997. Past and present NIH Supports: 1) “Hexose Phosphate Flux and Gluconeogenesis in NIDDM”, R01-DK46353, 4/1/93-3/31/97. 2) “General Clinical Research Center”, Co-PI, Anderson (PI), NIH/NCRR, M01 RR00425, 12/1/01 – 11/30/06 3) “Clinical Nutrition Research Unit: Stable Isotope Core”, PO1 CA42710-15SUBK, Co-PI, Heber (PI), 5/1/2000 – 4/30/2005 2
  3. 3. 4) “UCLA Center for Dietary Supplements Research: Botanicals”, 1 P50 AT00151, Co-PI, Heber (PI), 8/1/99 – 7/31/04 5) “Peroxisomal and Mitochondrial B-Oxidation in Obesity and Diabetes”, R01 DK56090, Lee (PI), 8/15/00 – 7/31/04. 6) “Hepatic Insulin Action: Role of the Pentose Cycle”, Co-PI, Kurland (PI), R01DK58132, 12/01/01- 11/30/06 7) “Metabolomics Core Laboratory” PI. NCCAM Center for Excellence in Pancreatic Diseases, P01 AT003960-01 10/01/07-9/31/11 Peer Reviewed Research Papers 1. Lee, W.N.P., Lippe, B.M., LaFranchi, S.H. and Kaplan, S.A.: Vasopressin analog (DDAVP) (1- desamino-8-arginine vasopressin) in the treatment of diabetes insipidus. Am J. Dis. Child. 130:166- 169, 1976. 2. Mpanias, P., Gollnick, D.A., Lee, W.N.P. and Greenfield, M.A.: Coincidence-counting assays of 123- I. J. Nucl. Med. 17:1111-1113, 1976. 3. Golden, M.P., Kaplan, S.A., Lippe, B.M. and Lee, W.N.P.: Value of simultaneous T-3, T-4 and TSH measurements for management of Graves' disease in children. Pediatr. 59:762-767, 1977. 4. Lee, W.N.P., Mpanias, P., Wimmer, R.J., Greenfield, M.A. and Kaplan, S.A.: Use of I-123 in early radioiodide uptake and its suppression in children and adolescents with hyperthyroidism. J. Nucl. Med. 19:789, 1978. 5. Takamoto, D.J., Lee, W.N.P., Kaplan, S.A. and Appleman, M.M.: Cyclic AMP phosphodiesterase in human lymphocytes and lymphoblasts. J. Cyclic Nucleotide Res. 4:123-132, 1978. 6. Lee, W.N.P., Golden, M.P., Van Herle, A,J., Lippe, B.M. and Kaplan, S.A.: Inherited abnormal thyroid hormone binding protein causing selective increase of total serum thyroxine. J. Clin. Endocrinol. Metab. 49:292298, 1979. 7. Harpen, M.D., Siegle, J.A., Lee, W.N.P. and Greenfield, M.A.: A new method of calculating absolute thyroid activity in intravenous I-123 uptake test. Med. Phys. 7:616-620, 1980. 8. Hendricks, S.A., Lippe, B.M., Kaplan, S.A. and Lee, W.N.P.: Differential diagnosis of diabetes insipidus: Use of DDAVP to terminate the seven hour water deprivation test. J. Pediatr. 98:244-246, 1980. 9. Harpen, M.D., Lee, W.N.P., Siegle, J.A. and Greenfield, M.A.: Simultaneous determination of free thyroxine and capacity of thyroxine-binding globulin. J. Nucl. Med. 22:246-252, 1981. 10. Whiting, J.S., Lee, W.N.P., Mpanias, P.D. and Greenfield, M.A.: Determination of spatially distributed thyroidal iodine activity using coincidence counting. Phys. Med. Biol. 26:921-924, 1981. 11. Harpen, M.D., Lee, W.N.P., Siegle, J.A. and Greenfield, M.A.: Serum binding of triiodothyronine: Theoretical and practical implications for in vitro triiodothyronine uptake. Endocrinol. 110:1732- 1739, 1982. 12. Lee, W.N.P., Siegle, J.A., Harpen, M.D., Greenfield, M.A. and Verma, R.C.: In vivo evaluation of intrathyroidal iodide metabolism. J. Clin. Endocrinol. Metab. 55:1131-1137, 1982. 13. Lee, W.N.P., Whiting, J., Fymat, A.L. and Boettger, H.G.: A least squares approach to the quantitation of stable isotope in mass spectrometry. J. Biomed. Mass Spectrom. 12:641-645, 1983. 14. Fymat, A.L., Greenfield, M.A. and Lee, W.N.P. Thyroid uptake measurements with I-123: Problems and pitfalls: Concise communication. J. Nucl. Med. 24:642-643, 1983. 15. Siegel, J.A., Lee, W.N.P., Harpen, M.D., Verma, R.C. and Greenfield, M.A. Quantitative differences between thyroid uptake of I-123 and pertechnetate. Eur. J. Nucl. Med. 9:494-498, 1984. 3
  4. 4. 16. Fymat, A.L., Greenfield, M.A. and Lee, W.N.P. Absolute radioassay of extended sources: An equivalent point source coincidence counting approach with application on the thyroid. Med. Phys. 12:127-134, 1985. 17. Katz, J., Lee, W.N.P., Wals, P.A. and Bergner, E.A. Studies of glycogen synthesis and the Krebs cycle by mass isotopomer analysis with U-13C-glucose in rats. J. Biol. Chem. 264:12994-13001, 1989. 18. Lee, W.N.P. Appendix: Analysis of mass isotopomer data. J. Biol. Chem. 264:13002-13004, 1989. 19. Cooper, D.M., Barstow, T., Bergner, E.A. and Lee, W.N.P. Blood glucose turnover during high and low intensity exercise. Am. J. Physiol. 20:E405-E412, 1989. 20. Fymat, A.L., Eisenman, J. I., Greenfield, M.A. and Lee, W.N.P. Organ characterization with nuclear medicine tomography. Appl. Math. Computation. 35:159-189, 1990. 21. Tayek, J., Bergner, E.A. and Lee, W.N.P. Correction of glucose carbon recycling for the determination of "true" hepatic glucose production (HGP) rates by [1-13C1]-glucose. Biomed. Environ. Mass Spectrom. 20:186-190,1991. 22. Lee, W.N.P., Byerley, L.O., E.A. Bergner, and J. Edmond: Mass isotopomer analysis: Theoretical and practical considerations. Biol. Mass Spectrom. 20:451-458, 1991. 23. Katz, J., Wals, P.A. and Lee, W.P.: Determination of pathways of glycogen synthesis and dilution of 13 the 3-carbon pool with [U- C6]-glucose. Proc. Natl. Acad. Sci. 88:2103-2107,1991. 24. Lee, W.N.P., Sorour, S. and Bergner, E.A.: Glucose isotope, carbon recycling and gluconeogenesis using [U-13C6]-glucose and mass isotopomer analysis. Biochem. Med. Metab. Biol. 45:298-309, 1991. 25. Katz, J. and W. P. Lee : The application of mass isotopomer analysis in the determination of pathways of glycogen synthesis. Am. J. Physiol. 259:E757-E762, 1991. 26. Lee, W.N.P., Guo, ZK and Bergner, E.A.: Mass isotopomer pattern and precursor-product relationship. Biol. Mass Spectrom. 21:114-122, 1992. 27. Guo, Z.K., Lee, W-N P., Bergner, A.E. and Katz, J. Quantitation of positional isomers of deuterium labeled glucose molecules with gas chromatography/mass spectrometry. Anal. Biochem. 204:273- 282, 1992. 28. Byerley, L.O., W-N. Paul lee, R.S. Swerdloff, F. Buena, K.S Nair, T.A. Buchanan, R. Goldberg, B. Steiner, and S. Bhasin. Effect of modulating serum testosterone levels in the normal male range on protein, glucose and lipid metabolism in men: Implication of testosterone replacement therapy. Endocrine J.: 1, 253-262, 1993. 29. Guo, Z.K., A.H. Luke, W-N. P. Lee, and D.A. Schoeller. Compound specific carbon-isotope ratio analysis of enriched cholesterol. Anal. Chem. 65: 1954-1959, 1993. 30. Katz, J., P.A. Wals, and W. P. Lee. Isotopomer studies of gluconeogenesis and the Krebs cycle with 13 C labeled lactate. J. Biol. Chem. 268: 25511-25521, 1993. 31. Lee, W-N. P. Appendix: analysis of tricarboxylic acid cycle using mass isotopomer ratios. J. Biol. Chem 268: 25522-25526, 1993. 32. Lee, W-N. P., S. Bassilian, ZK. Guo, D.A. Schoeller, J. Edmond, E.A. Bergner, and L.O. Byerley. Measurement of fatty acids and cholesterol synthesis rates using deuterated water (D2O) and mass isotopomer analysis. Am. J. Physiol. 266: E372-E383, 1994 33. Lee, W-N. P., S. Bassilian, H. Ajie, D.A. Schoeller, J. Edmond, E.A. Bergner, and L.O. Byerley. In vivo measurement of fatty acids and cholesterol synthesis using deuterated water (D2O) and mass isotopomer analysis. Am. J. Physiol. 266 : E699-E708, 1994. 4
  5. 5. 34. Goux, W. J., A. A. D. Strong, B. L. Schneider, W-N. P. Lee, and L. J. Reitzer. Utilization of aspartate as a nitrogen source in Escherichia coli: Analysis of nitrogen flow and characterization of the products of aspartate catabolism. J. Biol. Chem. 270(2), 638-646, 1995. 35. Lee, W-N. P., L.O. Byerley, S. Bassilian, H. O. Ajie, I. Clark, J. Edmond, and E. A. Bergner. Isotopomer study of lipogenesis in human hepatoma cells in culture: Contribution of carbon and reducing hydrogen from glucose. Anal Biochem. 226: 100-112, 1995. 36. Ajie, H. O., M. J. Connor, W. N. P. Lee, S. Bassilian, E. A.Bergner, and L. O. Byerley. In vivo study of the biosynthesis of long chain fatty acids (LCFA) using deuterated water (D2O). Am. J. Physiol. 269: E247-E252, 1995. 37. Bergner, E. A. and W.-N. P. Lee. Testing GC/MS systems for linearity of response. J. Mass Spectrom. 30, 778-780,1995. 38. Lee WP, Edmond J, Bassilian S, and Morrow J. Mass isotopomer study of glutamine oxidation and synthesis in primary culture of astrocytes. Develop. Neurosci. 18: 469-477, 1996. 39. Eliakim A, Barstow TJ, Brasel JA, Ajie HO, Lee WNP, Renslo R, Berman N and Cooper DM. The effect of exercise training on energy expenditure, muscle volume, and maximum oxygen uptake in adolescent females. J Pediatr. 129:537-543, 1996. 13 40. Kasho, V., Cheng, S., Jensen, D., Ajie, H., Lee, W-N. P. and L.D. Faller. Feasibility of analyzing C- urea breath tests for H. pylori by gas chromatography-mass spectrometery in the selective ion monitoring mode. Aliment Pharmacol Ther. 10:985-995, 1996. 41. Bhasin S, Storer TW, Berman N, Yarashesky K, Clevenger B, Phillips J, Lee WP, Bunnel TJ, Casaburi R. Replacement doses of testosterone increase fat-free mass and muscle size in hypogonadal men. J Clin Endocrinol Metab 82: 407-413, 1997. 42. Boros LG, Puigjaner J, Cascante M, Lee WNP, Brandes JL, Bassilian S, Yusuf FI, Williams RD, Muscarella P, WS Melvin and Schirmer WJ. Oxythiamine and Dehydroepiandrosterone Inhibit the Non-Oxidative Synthesis of Ribose and Tumor Proliferation. Cancer Research, 57: 4242-4248, 1997. 43. Boros, L.G., WN. P. Lee, J.L. Brandes, M. Cascante, P. Muscarella, W.J., Schirmer, W.S. Melvin, and E.C. Ellison. Non-oxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: Is cancer a disease of cellular glucose metabolism ? Medical Hypotheses 50, 55-59, 1998. 44. Edmond J, Higa TA, Korsak RA, Bergner EA, and Lee WNP. Fatty acid transport and utilization for the developing brain. J Neurochem. 70: 1227-1234 ,1998. 45. Ambler C, Eliakim A, Brasel JA, Lee WNP, Burke G and D Cooper. Fitness and the effect of exercise training on dietary intake of healthy adolescents. Internat. J Obesity. 22:354-362, 1998. 46. Lee WNP, Boros LG, Puigjaner J, Bassilian S, Lim S and Cascante M. Investigation of the pentose 13 cycle using [1, 2- C2]-glucose and mass isotopomer analysis: estimation of transketolase and transaldolase activities. Am. J. Physiol. 274: E843-E851, 1998. 47. Lee, W. P., S. Lim, S. Bassilian and E.A. Bergner. Calibration of IRMS Working Standard for 2H/1H Ratio Analysis. J Mass Spectrom 33: 627-630, 1998. 48. Buchanan T. A., A. Xiang, S. L. Kjos, W. P. Lee, E. Trigo, I. Nader, A. Bergner, J. L. Palmer and R. K. Peters. Gestational Diabetes Mellitus: Antepartum Metabolic Characteristics That Predict Postpartum Glucose Intolerance and Type 2 Diabetes. Diabetes 47: 1308-1316, 1998. 49. Lee, W. P., S. Lim, S. Bassilian, E.A. Bergner and J. Edmond. Troglitazone stimulates peroxisomal β-oxidation in human hepatoma cells. J Biol Chem 273: 20929-20934, 1998. 50. Xiang AH, Peters RK, Trigo E, Kjos SL, Lee WP and Buchanan TA. Multiple metabolic defects during late pregnancy in women at high risk for type 2 diabetes mellitus. Diabetes 48:848-54, 1999. 51. Radziuk, J and W-N P Lee. The measurement of gluconeogenesis using mass isotopomer analysis based on [U-13C6]-glucose. Am J. Physiol. 277: E199-E207, 1999. 5
  6. 6. 52. Radziuk, J and W-N P Lee. [U-13C6]-glucose and the estimation of gluconeogenic rates: Closing remarks. Am J. Physiol. 277:E414-6 1999. 53. Raïs B, Comin B, Puigjaner J, Brandes JL, Creppy E, Saboureau D, Ennamany R, Lee WNP, Boros LG and Cascante M. Oxythiamine and Dehydroepiandrosterone Induce a G1 Phase Cycle Arrest in Ehrlich’s Tumor Cells through inhibition of Pentose Cycle. FEBS Let. 456: 113-119, 1999 54. Lee WNP, Bassilian S, Lim S and Boros LG. Loss of regulation of lipogenesis in the Zucker diabetic (ZDF) rats Am J Physiol 279: E425-432, 2000. 55. Boros, LG, JS Torday, S Lim, S Bassilian, M Cascante, RL Veech and WNP Lee TGF-β2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells. Cancer Research 60:1183-1185, 2000. 56. Kurland, I.J., AA Alcivara, S. Bassilian, and W-NP. Lee. Loss of 13C-glycerol carbon via the pentose cycle: Implications for gluconeogenesis measurement by MIDA. JBC 275: 36787-36793, 2000. 57. Boros, LG, S Bassilian, S Lim, WNP Lee Genistein inhibits non-oxidative ribose synthesis in MIA pancreatic adenocarcinoma cells: a new mechanism of controlling tumor growth. Pancreas, 22: 1-7, 2001. 58. Boros, LG, Lapis, K., Szende, B., Tömösközi-Farkas, R., Balogh, A., Boren, J., Silvia Marin, S., Cascante, M., Lee WNP and Hidvégi, M. Wheat germ extract decreases glucose uptake and RNA ribose formation in MIA pancreatic adenocarcinoma cells. Pancreas 23: 141-147, 2001. 59. Comín B, Boren J, Martinez S, Moro C, Centelles JJ, Trebukhina R, Petushok N, Lee WNP, Boros LG and Cascante M. The effect of thiamine supplementation on tumor proliferation: A Metabolic Control Analysis study. Eur. J Biochem, 268: 4177-82, 2001. 60. Boren, J., Marin, S., Cascante, M, Lim, S, Bassilian, S, Syed, A and W-N P Lee. STI571 decreases glucose derived nucleic acid synthesis but increases direct glucose oxidation and lactate production in K562 myeloid blast cells. J Biol Chem 276: 37747-37753, 2001 61. Boros, LG, Lee WNP and VLW. Go. A Metabolic Hypothesis of Cell Growth and Death in Pancreatic Cancer. Pancreas 24:26-33, 2002. 62. Mao, CS, S Bassillian, SK. Lim and WNP Lee. Underestimation of gluconeogenesis by the [U13C6]- glucose method: Effect of lack of isotope equilibrium. Am J Physiol 282:E376-385, 2002. 63. Bassilian S, Ahmed S, Lim SK, LG, Boros, Mao CS, and Lee WNP. Loss of regulation of lipogenesis in the Zucker diabetic (ZDF) rat, II: Changes in stearate and oleate synthesis. Am J Physiol 282: E507-513, 2002. 64. Boros LG, Torday JS, Lee WNP and Rehan VK. Oxygen-induced metabolic changes and transdifferentiation in immature fetal rat lung lipofibroblasts. Mol Genet Metab.77: 230-236, 2002. 65. Xu J, Xiao G, Trujillo C, Chang V, Blanco L, Joseph SB, Bassilian S, Saad MF, Tontonoz P, Lee WN, Kurland IJ. Peroxisome Proliferator-activated Receptor alpha (PPARalpha ) Influences Substrate Utilization for Hepatic Glucose Production. J Biol Chem 277:50237-50244, 2002. 66. Xu, J., Xiao, G., W.N.P. Lee, Trujillo, C., Chang, V., Blanco, L., Hernandez, F, Chung, B, Makabi, S., Ahmed, S, Bassilian, S, Saad, M, and Kurland, I. J. Determination of a glucose dependent futile recycling rate constant from an IPGTT. Anal. Biochem 315: 238-246, 2003. 67. Boren, J., W-N P Lee, Bassilian S, Lim, S, Centelles JJ, Syed A, Boros LG and Cascante, M. The stable isotope-based dynamic metabolic profile (SIDMAP) of butyrate induced HT29 cell differentiation. J Biol Chem 278:28395-28402, 2003. 68. Boros LG, Steinkamp MP, Fleming JC, Lee WNP, EJ Neufeld. Defective RNA ribose synthesis in thiamine-responsive megaloblastic anemia (TRMA): mechanism for the syndrome. Blood. 102:3556- 61, 2003. 6
  7. 7. 69. Marin S, Chiang K, Bassilian S, Lee WNP, Fernández-Novell JM, Medrano A, Rodriguez-Gil JE, and M Cascante. Metabolomic characterization of boar spermatozoa reveals two possible energy substrate utilization profiles in mammalian spermatozoa. FEBS Letters, 554, 342-346, 2003. 70. Xu J., Chang, V., Joseph, S.B., Saad, M.F., Lee, W.N.P., and I.J. Kurland. Loss of PPARα diminishes insulin dependent gluconeogenic/ glycolytic signaling and substrate cycle flux. Endocrinology. 145:1087-1095, 2004. 71. Stiles B., Wang Y., Stahl A., Bassilian S., Lee WP, Wu J., Yoon-Jun Kim YJ., Sherwin R., Devaskar, S., Ralph Lesche R., Blavo B. and H. Wu. Liver specific deletion of Pten results in fatty liver and insulin hypersensitivity. Proc Natl Acad Sci U S A. 101:2082-7, 2004. 72. Marin S., Lee, WNP, Bassilian, S., Ahmed, S, Boros, LG, Centelles, J., Fernandez, JM, Cascante, M. Dynamic Profiling of the glucose metabolic network in fasted rat hepatocytes using [1,2-13C2]glucose Biochem J. 381:287-94, 2004. 73. Lee, WNP., Cascante, M. , Go, VLG., Guo, PZ., and LG. Boros. Glycogen phosphorylase inhibitor CP-320626 inhibits pentose cycle metabolism, glycolysis and fatty acid synthesis with a subsequent cycle arrest and apoptosis in pancreatic tumor cells. Br J Cancer. 91:2094-100, 2004. 74. Selivanov VA, Puigjaner J, Sillero A, Centelles JJ, Ramos-Montoya A, Lee PW, Cascante M. An optimized algorithm for flux estimation from isotopomer distribution in glucose metabolites. Bioinformatics. 20:3387-97, 2004. 75. Wong DA, Bassilian S, Lim S, Paul Lee WN. Coordination of peroxisomal beta-oxidation and fatty acid elongation in HepG2 cells. J Biol Chem 279: 41302–41309, 2004 76. Garg, M, Bassilian S, Bell, C, and W.N. P Lee. Hepatic de novo lipogenesis in stable low birth weight infants during exclusive breast milk feedings and during total parenteral nutrition. J Parenter Enteral Nutr. 29:81-6, 2005. 77. Wang C, Catlin DH, Starcevic B, Heber D, Ambler C, Berman N, Lucas G, Leung A, Schramm K, Lee PW, Hull L, Swerdloff RS. Low-fat high-fiber diet decreased serum and urine androgens in men. J Clin Endocrinol Metab. 90(6):3550-9, 2005. 78. Vizan P, Boros LG, Figuerasy A, Capellay G, Bassilian S, Lim S, Lee, WNP and M. Cascante. K-ras codon-specific mutations produce distinctive metabolic phenotypes in NIH3T3 fibroblasts. Cancer Res 65: 5512-5515, 2005. 79. Selivanov VA, Meshalkina LE, Solovjeva ON, Kuchel PW, Ramos-Montoya A, Kochetov GA, Lee PW, Cascante M. Rapid simulation and analysis of isotopomer distributions using constraints based on enzyme mechanisms: an example from HT29 cancer cells. Bioinformatics. 21(17):3558-64, 2005. 80. Garg M, Thamotharan M, Rogers L, Bassilian S, Lee WN, Devaskar SU. Glucose metabolic adaptations in the intrauterine growth-restricted adult female rat offspring. Am J Physiol Endocrinol Metab. 290(6):E1218-26. 2006. 81. Mizumori M, Meyerowitz J, Takeuchi T, Lim S, Lee P, Supuran CT, Guth PH, Engel E, Kaunitz JD, Akiba Y. Epithelial carbonic anhydrases facilitate pCO2 and pH regulation in rat duodenal mucosa. J Physiol. 2006 ;573(Pt 3):827-42. 82. Ramos-Montoya A, Lee WN, Bassilian S, Lim S, Trebukhina RV, Kazhyna MV, Ciudad CJ, Noe V, Centelles JJ, Cascante M. Pentose phosphate cycle oxidative and nonoxidative balance: A new vulnerable target for overcoming drug resistance in cancer. Int J Cancer.119(12):2733-41, 2006. 83. Xu J, Lee WN, Phan J, Saad MF, Reue K, Kurland IJ. Lipin deficiency impairs diurnal metabolic fuel switching. Diabetes. 2006 55(12): 3429-38.85. 84. Vo TD, Lim SK, Lee WNP, and BO Palsson. Isotopomer Analysis of Cellular Metabolism in Tissue Culture: A Comparative study between the pathway and network-based methods. Metabolomics 2:243-256, 2006. 7
  8. 8. 85. Xu J, Gowen L, Raphalides C, Hoyer KK, Weinger JG, Renard M, Troke JJ, Vaitheesyaran B, Lee WN, Saad MF, Sleeman MW, Teitell MA, Kurland IJ. Decreased hepatic futile cycling compensates for increased glucose disposal in the Pten hetero-deficient mouse. Diabetes 2006 55(12):3372-80. 86. Selivanov VA, Marin S, Lee PW, Cascante M. Software for dynamic analysis of tracer-based metabolomic data: estimation of metabolic fluxes and their statistical analysis. Bioinformatics. 22(22):2806-12, 2006. 88. Rehan VK, Wang Y, Sugano S, Santos J, Patel S, Sakurai R, Boros LW, Lee WP, Torday JS. In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism. Am J Physiol Lung Cell Mol Physiol. 292(1):L323-33, 2007. 89. Bartnik BL, Hovda DA, Lee WNP. Glucose Metabolism after Traumatic Brain Injury: Estimation of Pyruvate Carboxylase and Pyruvate Dehydrogenase Flux by Mass Isotopomer Analysis. J Neurotrauma 24: 181-194, 2007. 89. Centelles JJ, Ramos-Montoya AF, Lim SK, Bassilian S, Boros LG, Marín S, Cascante M, WN P Lee. Stable isotope tracer based quantitation and pathways of deoxyribose synthesis: Implications for de novo DNA synthesis and repair in HepG2 cells. Metabolomics 3:105-112, 2007. 90. Dusick J; Glenn T; Lee W-N; Vespa P; Kelly D; Lee S; Hovda D; Martin N. Increased Pentose Phosphate Pathway Flux Following Clinical Traumatic Brain Injury: A [1,2-13C2]-Glucose Labeling Study in Humans. Journal of Cerebral Blood Flow & Metabolism (2007), 1–10. 91. Vo TD, Lee WNP, and Palsson BO. Systems analysis of energy metabolism elucidates the affected respiratory chain complex in Leigh’s syndrome. Mol Genet Metab. 2007; 91(1): 15-22. 92. Thamotharan M, Garg M, Oak S, Rogers LM, Pan G, Sangiorgi F, Lee PW, Devaskar SU. Transgenerational inheritance of the insulin-resistant phenotype in embryo-transferred intrauterine growth-restricted adult female rat offspring. Am J Physiol Endocrinol Metab. 2007, 292(5):E1270-9. 93. Xiao G, Garg M, Lim S, Wong D, Go VL, WN P Lee Determination of Protein Synthesis Using in vivo Deuterium Labeling and Analysis of MALDI-TOF Spectrum. J. Appl. Physiol. 2008; 104(3):828-36. 94. Yee JK, Lim S, Mao CS, Sugano S, Rehan VK, Xiao G, Lee WNP. Compartmentalization of stearoyl-CoA desaturase enzyme-1 activity in HepG2 cells. J. Lipid Res (In press, 2008). 95. Shiraishi S, Lee WN P, Leung A, Goh, VHH, Swerdloff RS, Wang C. Simultaneous Measurement of Serum Testosterone and Dihydrotestosterone by Liquid Chromatography Tandem Mass Spectrometry. Submitted to Clinical Chemistry 1/08. 96. Wang C, Shiraishi S, Leung A, Baravarian S, Hull L, Goh V, Lee PW, Swerdloff RS. Validation of a Testosterone and Dihydrotestosterone Liquid Chromatography Tandem Mass Spectrometry Assay: Interference and Comparison with Established Methods. Steroid (in press 5/08). 97. Weis B, Hammock B, Lee W-N, Mendes P, Ramos K, Suk W and Lucier G. Application of metabolomics to toxicology and risk reduction. Env. Health Perspectives Toxicogenomics. (Submitted. March 2004). 98. Sakkour, SM, Samuel .W. French, SW, and W.N. P. Lee. Diabetes Control in Mauriac Syndrome: Report of Three Cases. (Submitted to Clinical Endocrinology 2/04). Reviews and Book Chapters 1. Lee, W.N.P. Thyroiditis, hyperthyroidism and tumors. Pediatric Clinics of America 26:53-63, 1979. 2. Lee, W.N.P. Thyroid physiology and thyroid function tests. In: Clinical Endocrinology of Children and Adolescents. S.A. Kaplan (ed), W.B. Saunders, Philadelphia, pp 69-81, 1982. 3. Lee, W.N.P., Katz, J., Sorour, S., Bergner, E.A.: Study of Krebs cycle metabolism using U13C- glucose and mass isotopomer analysis. Invited paper. In: Stable Isotopes in Pediatric Nutritional and 8
  9. 9. Metabolic Research. T.E. Chapman, R. Berger, D.J. Reijngoud and A. Okken, (eds), Intercept Ltd, Andover, Hampshire, England, pp 179-186, 1990. 4. Katz, J., Wals, P.A., Bergner, E.A. and Lee, W.N.P.: Mass isotopomer studies of glycogen synthesis in vivo. Invited paper. In: Alfred Benzon Symposium 30: Regulation of Hepatic Function. N. Grunnet and B. Quistorff, (eds), Munksgaard, Copenhagen, Denmark, p 400-414, 1991. 5. Lee, W. P., Byerley, L.O., Bassilian, S., Bergner, E. A. and Ajie, H. Can Binomial Approximation be used to describe deuterium isotopomer formation in Lipogenesis? In Modeling and Control in Biomedical System, Proceedings of the International Automatic Control (IFAC) Symposium. B. W. Patterson (ed), University of Texas Medical Branch, Galveston, TX , pp 352-353, 1994. 6. Lee, W. P. Stable isotope and mass isotopomer study of fatty acid and cholesterol synthesis: A review of the MIDA approach. In Dietary Fats, Lipids, Hormones and Tumorogenesis: New Horizons in Basic Research, D. Heber and D. Kritchevsky (eds), Plenum Publishers, pp 95-114, 1996. 7. Boros LG, Brandes JL, Lee WNP, Cascante M, Puigjaner J, Revesz E, Bray TM, Schirmer WJ, and WS Melvin. Thiamine supplementation to cancer patients: a double edged sword. Anticancer Research 18: 595-602, 1998. 8. Cascante, M., Comin, B., Boren, J., Raïs, B., Centelles, J.J., Puigjaner, J., Lee, W.-N. P., Boros, L.G. "Application of Metabolic Control Analysis to the Design of a New Strategy for Cancer Therapy", pp. 173-180 in "Technological and Medical Implications of Metabolic Control Analysis" (ed. A. Cornish- Bowden and M. L. Cárdenas), Kluwer Academic Publishers, Dordrecht (2000) 9. Cascante M, JJ Centelles, RL Veech, W-N P Lee and LG Boros. Metabolic control analysis aimed at the nucleic acid ribose synthesis pathways of tumors: the role of thiamin and transketolase in cell proliferation. Nutr. Cancer 36:150-154, 2000. 10. Boros, LG, Cascante, M, Go, VLW, Heber, D, Hidvégi, M and Lee, WNP. Metabolic Profiling of Cell Growth and Death in Cancer: applications in drug discovery. Drug Discovery Today 7:366-374 2002. 11. Cascante, M, L G. Boros, B. Comin, P Atauri, J. J. Centelles and W-N.P. Lee. Metabolic Control Analysis: A rational approach for new drug development. Nature Biotech 20: 243-249, 2002. 12. Boros LG, Lee WN, Cascante M. Imatinib and chronic-phase leukemias. N Engl J Med 347:67-8, 2002. 13. Boros LG, Cascante M, Lee WN. Stable Isotope-Based Dynamic Metabolic Profiling in Disease and Health: tracer methods and applications. (ed. George Harrigan) Kluwer Academic Publishers, Dordrecht (2002). 14. Go, VLW, Lee,YH and WNP Lee Neuro-hormonal integration of Metabolism: Challenges and opportunities in the post-genomic era. Nestle Nutrition Workshop Series (eds. S P Allison and VLW Go) Karger, Switzerland (2004) 15. Boros LG, NJ Serkova, MS. Cascante, and W-N P Lee. Use of metabolic pathway flux information in targeted cancer drug design. Drug Discovery Today: Therapeutic Strategies 1:435-443, 2004. 16. Lee WN, Go VL. Nutrient-gene interaction: tracer-based metabolomics. J Nutr. 2005 ;135(12):3027S-32S. 17. Go VL, Nguyen CT, Harris DM, Paul Lee WN. Nutrient-gene interaction: metabolic genotype- phenotype relationship. J Nutr. 2005;135(12):3016S-20S. 18. Lee WN. Characterizing metabolic phenotype using tracer-based metabolomics. Metabolomics 2006, 2: 31-39. 19. Boros LG, WNP Lee. Metabolic Network in Cancer. Chapter 4, Nutritional Oncology (eds. D Heber, GL Blackburn, VLW Go and J Milner) Academic Press, Burlington (2006) 9
  10. 10. 20. Maguire G, Boros LG and Lee P. Development of Tracer-Based Metabolomics and its Implications for the Pharmaceutical Industry. Int J Pharm Med 2007; 21 (3): 217-224. Invited Presentations: 1. Lee, W.N.P., Katz, J., Sorou, S., Bergner, E.A. Study of Krebs cycle metabolism using U13C-glucose and mass isotopomer analysis. Presented at the Symposium on Stable Isotopes in Pediatric Nutritional and Metabolic Research. Groningen, Netherlands, 1989. 2. Katz, J., Wals, P.A., Bergner, E.A., Lee, W.N.P. Studies of glucose metabolism by 13C mass isotopomer analysis. Invited paper. Presented at the Alfred Benzon Symposium No. 30, Copenhagen, Denmark, June, 1990. 3. Katz, J., Wals P.A. and Lee, W-N.P. The application of mass isotopomer analysis to the study of gluconeogenesis. Invited paper. Presented at the Symposium on Advances in Regulation of Carbohydrate Metabolism (sponsored by the International Union of Biochemists), Jerusalem, Israel, July, 1991. 4. Edmond, J., R.A. Cole, P.N. Bullock, J.W. Morrow, E.A. Bergner, S. Bassilian and W. P. Lee. Metabolic diversity and specialization of substrate use by neural cells from developing brain in primary culture. Presented at the Satellite Symposium on "Functional aspects of energy metabolism in neural tissue", 1993 Annual Meeting of the International Society of Neurochemists, Carcassonne, France. 5. Lee, W-N. P., J. Edmond, S. Bassilian and J. W. Morrow. Mass isotopomer study of glutamate metabolism by astrocytes in primary culture. Presented at the Second International Conference on Brain Energy Metabolism, Blaubeuren, Germany, August, 1995. 6. Lee, W-N. P. The study of metabolic fluxes of the tricarboxylic acid cycle using carbon-13 tracers. Presented at the International Workshop on Design and Evolution of Metabolism, Tenerife, Spain, September 20-23, 1995. 7. Lee W-N P, Mao CS, Bassilian S, Lim S and EA Bergner. Study of Glucose Carbon Recycling, Cori Cycle and Gluconeogenesis Using [U13C]-glucose and Mass Isotopomer Analysis. Invited Presentation at the Symposium on In Vivo Measurement of Metabolic Processes, Prouts Neck, Maine, October, 1997. 8. Cascante M, Comin B, Boren J, Moro C, Martinez S, Centelles JJ, LeeW-N.P. and Boros L.G. Inhibition of tumor ribose-phosphate synthesis: A new strategy to control tumor proliferation. Plenary lecture at ComBio99, Darwin, Australia, 1999. 9. Boros, L.G., Go, V.L., Lee, W-N.P. Metabolic Profiling of Cell Growth and Death in Cancer. Presented at the Cambridge Healthtech Institute’s Premier Conference on Metabolic Profiling: Pathways to Discovery (Invited presentation, keynote address), Sheraton Chapel Hill Hotel, Chapel Hill, North Carolina, December 4, 2001. 10. Kurland I.J., J. Xu,G. Xiao, C. Pelayo,. F. Hernandez, A. Alcivar, B. Chung, S. Bassilian, M. Saad, W.N.P. Lee. Metabolic flux analysis using 13C mass spectrometry for the investigation of hepatic insulin signaling. (Invited presentation) Pathways in Discovery Conference, Chapel Hill, NC, December 3-4, 2001. 11. Lee WN P., L.G. Boros and CS Mao. Tracer Approaches to determining gluconeogenesis. Invited presentation, Nutrition Week 2003, San Antonio, TX, 2003. 12. Lee, WNP. Developing Risk Reduction Strategies through Metabolic Profiling. Invited presentation. Presented at Metabolic Profiling: Application to Toxicology and Risk Reduction, An International Conference Research Triangle Park, North Carolina, May 14-15, 2003. 10
  11. 11. 13. Lee WNP, Wong D and Boros LG. The Nature of Metabolomics Data. Presented at the First International Meeting of the Metabolomics Society, Turuoka, Japan, June 2005. 14. Lee WNP and VLW Go. Nutrient-Gene Interaction: Tracer-Based Metabolomics. Invited presentation at the AICR/WCRF International Research Conference on Food, Nutrition and Cancer, Washington DC, July 2005. 15. Lee WNP. Glucose Metabolic Phenotypes in Cancer. Invited presentation at the NCI Conference “Frontiers in Metabolomics for Cancer Research”, Washington DC, October, 2005 Abstracts 1. Kirsch, J.K. and Lee, W.N.P. The chemical reactivity of hydroxy-trihydroborate anion: The reduction of esters and thioesters. Presented at the American Chemical Society Meeting, 1967. 2. Wimmer, R.J., Lee, W.N.P., Kaplan, S.A. and Greenfield, M.A. Estimation of absolute iodide uptake (AIU) with I-123 by coincidence counting. Presented at the American Radiological Society of North America Meeting, December 1975. 3. Lee, W.N.P., Wimmer, R.J., Kaplan, S.A. and Greenfield, M.A. I-123 early radioiodine uptake test as a prediction of outcome in children with thyrotoxicosis. Pediatr. Res. 11:428, 1977. 4. Mpanias, P., Lee. W.N.P., Greenfield, M.A., Spiegler, P. and Herman, M. Coincidence counting method of assessing low level activity in electron capture decaying radionuclide. Presented at the Health Physics Society Conference in San Diego, December, 1977. 5. Lee, W.N.P., Golden, M.P., Van Herle, A.J., Lippe, B.M. and Kaplan, S.A. A new inherited abnormal thyroid hormone binding protein causing selective increase of total serum thyroxine. Western Society for Pediatric Research. Clin. Res. 26:170A, 1978. 6. Whiting, J.S., Britt, A., Lee, D., Lee, W.N.P. and Greenfield, M.A. Using of radionuclides which emit photon in coincidence for determination of physiological data. Presented at Western Regional Meeting of the Society of Nuclear Medicine. Vancouver, Canada, August, 1978. 7. Whiting, J.S., Britt, A., Mackintosh, R., Mpanias, P.D., Lee, W.N.P. and Greenfield, M.A. The coincidence counting technique for 1-123 distributed in an absorbing medium. Presented at the 64th Annual Meeting of the Radiological Society of North America, November, 1978. 8. Mackintosh, R., Lee, W.N.P. and Greenfield, M.A. Sensitive method for measurement of total iodide content in thyroid disease. Presented at the 64th Annual Meeting of Radiological Society of North America, November, 1978. 9. Britt, A., Whiting, J.S., Lee, W.N.P. and Greenfield, M.A. Effective renal plasma flow from compartmental modelling: Influence of external variables. Presented at the Annual Meeting of the American Association of Physicists in Medicine, Southern California Chapter, Las Vegas, Nevada, April, 1979. 10. Harpen, M.D., Siegle, J.A., Lee, W.N.P. and Greenfield, M.A. A new method of neck background correction for intravenous I-123 thyroid uptake. Presented at the 65th Annual Meeting of the Radiological Society of North America, November, 1979. 11. Harpen, M.D., Siegle, J.A., Lee, W.N.P. and Greenfield, M.A. Determination of absolute thyroid activity in the presence of neck background for early I-123 thyroid uptake. Presented at the Annual Meeting of the American Association of Physicists in Medicine, Southern California Chapter, Las Vegas, Nevada, April, 1980. 12. Harpen, M.D., Siegle, J.A., Lee, W.N.P. and Greenfield, M.A. Separation of thyroid and extrathyroidal neck activities by means of coincidence counting. Presented at the 22nd Annual Meeting of the American Association of Physicists in Medicine, 1980. Medical Physics 7:430, 1980. 11
  12. 12. 13. Lee, W.N.P., Harpen, M.D., Siegle, J.A. and Greenfield, M.A. Application of a competitive binding technique for the evaluation of abnormal thyroxine binding proteins. Presented at the 22nd Annual Meeting of the American Association of Physicists in Medicine. Medical Physics 7:430, 1980. 14. Siegle, J.A., Verma, R.C., Lee, W.N.P., Harpen, M.D. and Greenfield, M.A. A new sensitive method for quantitating early Tc99m pertechnetate thyroid uptake. Presented at the Annual Meeting of Western Regional Society of Nuclear Medicine, October, 1980. Clin. Nucl. Med. 5:523, 1980. 15. Lee, W.N.P., Geffner, M.E., Kaplan, S.A., Lippe, B.M., Van Herle, A.J. and Harpen, M.D. Hypothyroxinemia of the premature neonate: A new method of assessment. Clin. Res. 29:110A, 1981. 16. Siegle, J.A., Verma, R.C., Lee, W.N.P., Harpen, M.D. and Greenfield, M.A. Quantitative thyroid uptake determination using Tc99m pertechnetate. Presented at the Annual Meeting of the American Association of Physicists in Medicine, Southern California Chapter, Las Vegas, Nevada, April, 1981. 17. Harpen, M.D., Lee, W.N.P., Siegle, J.A. and Greenfield, M.A. Serum binding of triiodothyronine. Presented at the Annual Meeting of the American Association of Physicists in Medicine, Southern California Chapter, Las Vegas, Nevada, April, 1981. 18. Siegle, J.A., Lee, W.N.P., Harpen, M.D., Verma, R.C. and Greenfield, M.A. A compartmental model for the kinetics of the thyroid uptake of iodide. Presented at the 23rd Annual Meeting of the American Association of Physicists in Medicine. Medical Physics 8:568, 1981. 19. Siegle, J.A., Lee, W.N.P., Harpen, M.D., Verma, R.C. and Greenfield, M.A. Kinetics of I-123 and pertechnetate compared using compartmental analysis. Presented at the 23rd Annual Meeting of the American Association of Physicists in Medicine. Medical Physics 8:567, 1981. 20. Lee, W.N.P., Siegle, J.A. Harpen, M.D., Greenfield, M.A. and Verma, R.C. In vivo evaluation of intrathyroidal iodide metabolism. Western Society for Pediatric Research. Clin. Res. 30:113A, 1982. 21. Lee, W.N.P., Van Herle, A.J., Harpen, M.D. and Aron, D. Purification of a new thyroxine binding protein. Presented at the Annual Meeting of the Western Society for Pediatric Research., Clin. Res. 30:114A, 1982. 22. Harpen, M.D., Lee, W.N.P., Mockridge, P., Robinson, A.E. and Siegle, J.A. Role of T-3 uptake in the evaluation of serum thyroxine binding abnormalities. Presented at the 29th Annual Meeting of the Society of Nuclear Medicine, June, 1982. 23. Harpen, M.D. and Lee, W.N.P. Influence of secondary binding site of the distribution of protein bound thyroid hormones. Western Society for Pediatric Research. Clin. Res. 30:114A, 1982. 24. Lee, W.N.P., Harpen, M.D., Dekeyser, L., Costin, A. and Van Herle, A.J. Familial euthyroid hyperthyroxinemia (FEH): Demonstration of two thyroxine binding albumins. Endocrine Society Annual Meeting, 1983. 25. Lee, W.N.P., Geffner, M.E., Kaplan, S.A., Lippe, B.M. and Jenden, D.F. N Nitrogen catabolism and diabetic control: Demonstration using stable isotopes. Western Society for Pediatric Research. Clin. Res. 32:112A, 1984. 26. Lee, W.N.P. Estimate of glucose recycling in rabbits using 13C glucose and mass fragmentography. ADA Annual Meeting. Diabetes 34(Suppl 1):185A, 1985. 27. Kaplan, S.A., Lee W.N.P. and Scott, M.L. Glucose inhibits myoinositol (MI) transport and phosphatidylinositol (PI) formation in adipocytes. implication for mechanisms of cell damage in diabetes. ADA Annual Meeting. Diabetes 34(Suppl 1):183A, 1985. 28. Kaplan, S.A., Lee, W.N.P., Geffner, M.E., Lippe, B.M., Scott, S. High glucose concentrations impair transport of precursor of polyphosphoinositide messenger system in isolated rat glomeruli. Presented at 68th Endocrine Society Annual Meeting, 1986. 12
  13. 13. 29. Cooper, D.M., Barstow, T., Lee, W.N.P. and Bergner, E.A. Glucose turnover and recycling during exercise in normal subjects. Presented at the Western Society for Pediatric Research. Clin. Res. 35:500A, 1987. 30. Cooper, D.M., Barstow, T., Bergner, E.A. and Lee, W.N.P. Evidence for a threshold of glucose uptake increase during exercise in man. Presented at the American Physiological Society Fall Meeting, 1987. 31. Lee, W.N.P., Cooper, D.M, Barstow, T. and Bergner, A.E. Lack of glucose carbon recycling during exercise in normal subjects. Presented at the Western Society for Pediatric Research Meeting. Clin. Res. 36:214A, 1988. 32. Lee, W.N.P., Katz, J., Bergner, E.A. and Wals, P.A. Hepatic glycogen repletion: A stable isotope study using U13C-glucose. Western Society for Pediatric Research. Clin. Res. 36:215A, 1988. 33. Lee, W.N.P., Wals, P.A. and Katz, J. Mass isotopomer pattern in liver glycogen from U-13C- glucose. Presented at the FASEB Annual Meeting. FASEB J. 2:A1362, 1988. 34. Lee, W.N.P. and Bergner, E.A. Study of Krebs cycle metabolism and glucose carbon recycling using U-13C-glucose and isotopomer analysis in diabetic rabbits. Presented at the Western Society for Pediatric Research. Clin. Res. 37:193A, 1989. 35. Hellerstein, M.K., Wu, K., Kaempfer, S. and Lee, W.N.P. Non-invasive studies of intracellular metabolism in human subjects using mass spectrometry (MS). I) Glucuronide probe. Presented at the Western Society for Pediatric Research. Clin. Res. 37:130A, 1989. 36. Hellerstein, M.K., Wu, K., Kaempfer, S., Lee, W.N.P., Reid, S. and Shackleton, C.H.L. Non- invasive studies of intracellular metabolism in human subjects using mass spectrometry (MS) I) Glucuronide probe. Presented at the FASEB Annual Meeting. FASEB J. 3:A244, 1989. 37. Lee, W.N.P., Katz, J., Sorou, S., Bergner, E.A. Study of Krebs cycle metabolism using U13C- glucose and mass isotopomer analysis. Presented at the Symposium on Stable Isotopes in Pediatric Nutritional and Metabolic Research. Groningen, Netherlands, 1989. 38. Tayek, J.A., Bergner, E.A., Lee, W.N.P. Correction of glucose carbon recycling for the determination of "true" hepatic glucose production (HGP) rates by 1-13C1-glucose. Presented at the Western Society for Pediatric Research. Clin. Res. 38:570A, 1990. 39. Edmond, J., Korsak, R.A., Bergner, E.A., Lee, W.N.P. Mass isotopomer analysis of sterols biosynthesized from carbon-13 glucose in brain of the gastrostomy reared rat pup. Presented at the FASEB Annual Meeting. FASEB J. 4:A1923, 1990. 40. Katz, J., Wals, P.A., Bergner, E.A., Lee, W.N.P. 13C mass isotopomer analysis of glucose metabolism. Presented at the FASEB Annual Meeting. FASEB J. 4:A2009 1990. 41. Lee, W.N.P., Bergner, E.A., Wals, P.A., Katz, J. Effect of glucose load on Krebs cycle parameters studied by U-13C-lactate. Presented at the FASEB Annual Meeting. FASEB J. 4:A1922, 1990. 42. Katz, J., Wals, P.A., Bergner, E.A., Lee, W.N.P. Studies of glucose metabolism by 13C mass isotopomer analysis. Invited paper. Presented at the Alfred Benzon Symposium No. 30, Copenhagen, Denmark, June, 1990. 43. Lee, W.N.P., Bergner, E.A., Byerley, L., Korsak, R.A. and Edmond, J.: Evidence of acetoacetate channeling in brain sterol biosynthesis. Clin. Res. 39:133A, 1991. 44. Ipp, E., Cortez, C., Bergner, E.A., Lee, W.N.P. Sulphonylureas are effective to inhibit hepatic glucose output in poorly controlled NIDDM. Presented at the 14th IDF Congress, Washington, DC, June 1991. Diab.: 40:1379, 1991. 45. Edmond, J.,Korsak, R.A., Auestad, N., Morrow, J.W., Marbois,B.N., Byerley, L.O. and Lee, W-N. P. Formation and function of ketone bodies in the brain. Presented at the 13th International Society of Neurochemists Meeting, Sydney, Australia. J. Neurochem. 57: S22, 1991. 13
  14. 14. 46. Katz, J., Wals P.A. and Lee, W-N.P. The application of mass isotopomer analysis to the study of gluconeogenesis. Invited paper. Presented at the Symposium on Advances in Regulation of Carbohydrate Metabolism (sponsored by the International Union of Biochemists), Jerusalem, Israel, July, 1991. 47. Barstow, T.J., Lee, W-N. P., Cooper, D.M., and Wasserman, K. Sources of blood lactate below and above the lactate threshold. Presented at the 1992 American College of Sports Medicine Annual Meeting, Indianapolis, IN, 48. Guo, Z.K., Lee, W-N P., and Katz, J. Quantitation of positional isomers of deuterium labeled glucose molecules with gas chromatography/mass spectrometry. Presented at the 1992 Annual FASEB Meeting, Bethesda, MD. FASEB J. 6: A1667, 1992. 49. Lee, W.P., Z-K. Guo, and J. Katz. Quantitation of gluconeogenesis using deuterated water (D2O). Submitted to the Nineth International Congress of Endocrinology, Nice, France (1992) 50. Byerley, L.O., Innis, G., Bassilian, S., Bergner, E.A., and Lee, W.P. Lactate metabolism in non- cachetic and cachetic tumor bearing rats. Abstract presented at the Annual Meeting of the AACR, 1992. 51. Byerley, L.O., Bassilian, S., Bergner, E.A., and Lee, W.P. Use of D2O to quantiate in vivo cholesterol and fatty acid synthesis in tumor bearing rats. Presented at the 1993 Annual meeting of FASEB, New Orleans, LO. FASEB J. 7: A288, 1993. 52. Katz, J., Wals, P., Bassilian, S. and Lee, W-N. P. The incorporation of deuterium in glycogen and recycling. Presented at the Annual Meeting of the American Diabetes Association, Las Vegas, NV. Diabetes 42: 124A, 1993. 53. Lee, W-N. P., Bassilian, S., Bergner, A.E., Wals, P. and Katz, J. Determination of fractional rate of gluconeogenesis by mass isotopomer analysis. Presented at the Annual Meeting of the American Diabetes Association, Las Vegas, NV. Diabetes 42: 178A, 1993. 54. Edmond, J., R.A. Cole, P.N. Bullock, J.W. Morrow, E.A. Bergner, S. Bassilian and W. P. Lee. Metabolic diversity and specialization of substrate use by neural cells from developing brain in primary culture. Presented at the Satellite Symposium on "Functional aspects of energy metabolism in neural tissue", 1993 Annual Meeting of the International Society of Neurochemists, Carcassonne, France. 55. Lee, W-N. P., Bassilian, S., Bergner, A.E., Wals, P. and Katz, J. Mass isotopomer study of gluconeogenesis with 13C-labeled lactate in man. Presented at the 1994 Annual Meeting of the Western Society for Pediatric Research, Carmel, CA. Clin. Res. 42: 28A, 1994. 56. Buchanan, T.A., H. Bruschetta, Steil, G.M., Nader, I., Lee, W.P., and Bergman, R.N. Measurement of basal glucose turnover in women with gestational diabetes: A comparison of three methods. Presented at the 1994 Annual Regional Meeting of the Federation for Clinical Research, Carmel, CA. Clin. Res. 42: 64A, 1994. 57. Lee, W. P., Byerley, L.O., Bassilian, S., Bergner, E. A. and Ajie, H. Can Binomial Approximation be used to describe deuterium isotopomer formation in Lipogenesis? Symposium on Modeling and Control in Biomedical System, International Automatic Control, March 1994, Galveston, TX. 58. Ajie, H., Conner, M.J., Lee, W. P., Bassilian, S., and E. A. Bergner. Study of biosynthesis of long chain fatty acids using deuterated water in vivo. Presented at the Annual Meeting FASEB 1994. FASEB J. 8: A918, 1994. 59. Lee, W. P.. Bassilian, S., Bergner, E. A., Ajie, H., and D. Schoeller. Turnover of lipids in diabetic nerve tissues. Annual Meeting of the American Diabetes Association, June, 1994, New Orleans, LA. Diabetes 43: 786A, 1994. 14
  15. 15. 60. Bergner, E. A. and W.-N. P. Lee. Testing GC/MS systems for linearity of response. Presented at the Third International Symposium on Mass Spectrometry in the Health and Life Sciences, September, 1994, San Francisco, CA. 13 61. Tayek, J. A., W.-N. P. Lee and J. Katz. U- C-lactate infusion in humans to estimate Krebs cycle parameters. Submitted for the Annual Regional Meeting of the American Federation for Clinical Research, Feb 1995, Carmel, CA. 62. Tayek, J. A., J. Katz and W.-N. P. Lee. Simultaneous estimation of hepatic glucose produce carbon recycling in Type II diabetes using mass isotopomer analysis. Submitted for the Annual Regional Meeting of the American Federation for Clinical Research, Feb 1995, Carmel, CA. 63. Lee, W. P., S. Bassilian, E. A. Bergner and H. O. Ajie Lipogenesis is less affected by diabetes in nerve tissues as in the liver. Presented at the Annual Meeting of the Western Society for Pediatric Research, Feb 1995, Carmel, CA. 64. Trigo E. , J. Diaz, I. Nader, G. Sipos, E. A. Bergner, W. P. Lee, and T. Buchanan. Insulin sensitivity in women with gestational diabetes: euglycemic clamp and minimal model techniques. Presented at the Annual Regional Meeting of the American Federation for Clinical Research, Feb 1995, Carmel, CA. 65. Lee, W. P., S. Bassilian, E. A. Bergner and H. O. Ajie. Glycemic control results in elevated hepatic lipogenesis in diabetic animals. Submitted for the Annual Meeting of the American Diabetes Association, June 1995, Atlanta, GA. 66. Lee, W. P., C. Mao, S. Bassilian, and E. A. Bergner. Stable isotope study of splanchnic and peripheral disposal of oral glucose in man. Submitted for the Annual Meeting of the American Diabetes Association, June 1995, Atlanta, GA. 67. Bruschetta, H., G. Steil, I. Nader, E. A. Bergner, W. P. Lee and T. Buchanan. Reduced glucose Production accounts for the fall in plasma glucose during brief extension of an overnight fast in women with gestational diabetes. Presented at the 55th Annual Meeting of the American Diabetes Association, June 1995, Atlanta, GA. 68. Ipp, E., C. Cortez, A. Bergner, C. Fischette and W-N. P. Lee. Glipizide-GITS inhibits hepatic glucose production in NIDDM. Presented at the 77th Annual Meeting of the Endocrine Society, Washington, DC, June, 1995. 69. Lee, W-N. P., J. Edmond, S. Bassilian and J. W. Morrow. Mass isotopomer study of glutamate metabolism by astrocytes in primary culture. Presented at the Second International Conference on Brain Energy Metabolism, Blaubeuren, Germany, August, 1995. 70. Lee, W-N. P. The study of metabolic fluxes of the tricarboxylic acid cycle using carbon-13 tracers. Presented at the International Workshop on Design and Evolution of Metabolism, Tenerife, Spain, September 20-23, 1995. 71. Lee, W. P., A. Clark, S. Lim, E. A. Bergner and J. Edmond Amino acid utilization by fibroblasts in congenital lactic acidosis. Presented at the Annual Meeting of the Western Society for Pediatric Research, Feb 1996, Carmel, CA. 72. Mao, C. S., Lee, W. P., S. Bassilian, and E. A. Bergner. Stable isotope study of splanchnic and peripheral disposal of oral glucose in man. Presented at the Annual Meeting of the Western Society for Pediatric Research, Feb 1996, Carmel, CA. 73. Edmond, J., Higa, T. A., Korsak, R. A., Bergner, E. A. and Lee, W-N. P. The source of fatty acids in developing brain. Presented at the 27th Annual Meeting of theAmerican Society of Neurochemistry, March 1996. (J. Neurochemistry) 74. Lee, W-N. P, Edmond, J., Higa, T. A., Korsak, R. A., and Bergner, E. A.. Fatty acid transport and utilization in the developing brain. Presented at FASEB Meeting, Washington DC, April 1996. 15
  16. 16. 75. Rajavashisth T. B., Bergner E. A., Clinton S. K., and W-N. P. Lee. Dietary Fat Intake Does Not Affect Cholesterol Recycling in Low Density Lipoprotein Receptor-Deficient Mice. Presented at FASEB Meeting, Washington DC, April 1996. 76. Kasho, V., Cheng, S., Jensen, D. M., Ajie, H., Lee, W-N. P., and L. D. Faller. Analysis of 13C-urea breath tests for H. Pylori by gas chromatography-mass spectrometry in the selected ion monitoring mode. Submitted to the Annual Meeting of American Gastroenterological Association and the American Association for the Study of Liver Diseases, San Francisco, May 1996. 77. Trigo, E., Diaz, J., Yegiant, L., Nader, I., Kjos, S., Peters, R., Lee, W.P. and Buchanan, T. Suppression of glucose productiobn by insulin parallels suppression of plasma free fatty acids in gestational diabetes. Presented at the 56th Annual Meeting of the American Diabetes Association, June 1996. 78. Buchanan, T., Xiang, A., Peters, R., Kjos, S., Nader, I., Trigo, E., Sipos, G., Diaz, J., Salce, M., Lee, W.P. and Novilla, L. Pancreatic B-cell defect during pregnancy predicts persistence of abnormal glucose tolerance after pregnancies complicated by gestational diabetes. Presented at the 56th Annual Meeting of the American Diabetes Association, June 1996. 79. Lee WP, Bergner AE, Clinton SK, and Rajavashisth TB. Hypercholesterolemia is associated with different lipid turnover in low density lipoprotein receptor and apo e-deficient mice. Presented at the Annual Meeting of the Endocrine Society, San Francisco, June 1996. 80. Lee WNP, Boros LG, Brandes JL, Bassilian S, Tamaddon M, Muscarella P, Sajago MM and Melvin WS. Isotopomer analysis of glucose carbon incorporation into RNA ribose indicates direct pathway of ribose synthesis in cultured pancreatic adenocarcinoma cells. Presented at the Annual Meeting of the Western Society for Pediatric Research, Feb 1997, Carmel, CA. 81. Rajavashisth TB, Sinha Hikim AP, Mishra NK, Cai Y, Tripathi JN, Lue YL, Wang C, Baravarian S, Leung A, Lee WNP, and Swerdloff RS. Mice deficient in macrophage colony stimulating factor exhibit reduced testicular testosterone and augmented stage specific germ cell apoptosis. Presented at the 6th International Congress of Cell Biology and 36th Annual meeting of American Society for Cell Biology, December 1996, San Francisco, CA. 82. Boros LG, Lee WNP, Muscarella P, Fisher WE, Schirmer WJ, and Melvin WS. Inhibitors of the oxidative and non-oxidative pathways inhibit pancreatic can cell proliferation. Presented at the Annual Meeting of American Gastroenterological Association and the American Association for the Study of Liver Diseases, May 1997, Washington, DC. 83. Lee W-N P, Mao CS, Bassilian S, Lim S and EA Bergner. Study of Glucose Carbon Recycling, Cori Cycle and Gluconeogenesis Using [U13C]-glucose and Mass Isotopomer Analysis. Invited Presentation at the Symposium on In Vivo Measurement of Metabolic Processes, Prouts Neck, Maine, October, 1997. 84. Lee WP, Bassilian S, Lim S and EA Bergner. Troglitazone inhibits glucose utilization for lipogenesis in Hep G2 cells in culture. Presented at the Annual Meeting of the Western Society for Pediatric Research, Feb 1998, Carmel, CA. 85. Chen DC, Mao CS, Dinh T. and WNP Lee. Coexistence of obesity and insulin resistance in Hispanic type 1 diabetic patients? Presented at the Annual Meeting of the Western Society for Pediatric Research, Feb 1998, Carmel, CA. 86. Lee WP, Lim S, Bassilian S, Bergner EA and J. Edmond. Effect of troglitazone on stearate and oleate metabolism. Submitted to FASEB Meeting, San Francisco, CA, April 1998. 87. Edmond J, Korsak RA, Bergner EA, and WP. Lee. Impact of DHA supplementation in milk on linolenate metabolism in liver and brain of the developing rat. Submitted to FASEB Meeting, San Francisco, CA, April 1998. 16
  17. 17. 88. Boros, L.G., Comin, B., Puigjaner, J., Brandes, J.L., Muscarella, P., Yusuf, F., Williams, R.D., Lee, W.P., Cascante, M., Schirmer, W.J., Melvin, W.S. Orally administered dehydroepiandrosterone increases G6PD and transketolase activity in tumor tissue. Gastroenterology 114(4):A567, 1998. 89. Buchanan, T., A. Xiang, R. Peters, E. Trigo, S. Kjos, I. Nader, A. E. Bergner, W. P. Lee. Elevated Basal Glucose Production During Late Pregnancy Predicts Type 2 Diabetes Within 15 Months After Pregnancies Complicated By Gestational Diabetes. Presented at the American Diabetes Association Meeting, June 1998. 90. Lee, WP, S Bassilian and S Lim. Effect of troglitazone on fatty acid cycling and lipogenesis in HEP G2 cells in culture. Presented at the Annual Meeting of WSPR, Carmel, 1999. 91. Buchanan, TA, Xiang AH, Tan S, Peters RK, Trigo E, Kjois SL, Lee WP, and Azen S. Comparison of antipartum and early postpartum characteristics as predictors of type 2 diabetes following gestational diabetes in Latino women. Submitted to the Annual Meeting of the American Diabetes Association, San Diego, 1999. 92. Lee, WP, Bassilian S, Lim S, and Boros LG. Effect of Dietary Fat on Chain Elongation and de novo Lipogenesis. Presented at the Annual Meeting of the American Diabetes Association, San Diego, 1999. 93. Wang C, D Catlin, C Ambler, N Berman, G. Lucas, A Leung, P Lee, B Starcevic, K. Schramm, RS Swerdloff. Dietary Fat Modulation of Androgen Metabolism in Normal Men. Presented at the Annual Meeting of the Endocrine Society, San Diego, 1999. 94. Lee WNP, Bassilian S, Lim S and Boros LG. Loss of regulation of lipogenesis in the Zucker Diabetic (ZDF) rats. Presented at the Annual Meeting of the NAASO, Charleston, 1999. 95. Cascante M, Comin B, Boren J, Moro C, Martinez S, Centelles JJ, LeeW-N.P. and Boros L.G. Inhibition of tumor ribose-phosphate synthesis: A new strategy to control tumor proliferation. Plenary lecture at ComBio99, Darwin, Australia, 1999. 96. Kurland I., A. Alicivar, S Bassilian and W. P. Lee. Is pentose cycle the indirect pathway ? Submitted to the Annual Meeting of WSPR, Carmel, 2000. 97. Mao, C.S., Bassilian, S., Lim, S.K. and W.N.P. Lee. Underestimation of gluconeogenesis by the U13C-glucose method: Effect of lack of isotope equilibrium. Presented at the Annual Meeting of WSPR, Carmel, 2000. 98. Boros, L. G., J. S. Torday, S. Lim, S. Bassilian, M. Cascante, and W. N. P. Lee. TGF-β2 increases tumor cell glucose utilization and the synthesis of nucleic acid ribose through the non-oxidative pentose cycle in lung carcinoma cells. Presented at the Annual Meeting of AACR, San Francisco 2000. 99. Boros, L. G., B. Comin, J. Boren, S. Martinez, C. Moro, J. J. Centelles, R. Trebukina, W. N. P. Lee, and M. Cascante. Over-expression of the transketolase enzyme: A mechanism by which thiamine supplementation promotes cancer growth. Presented at the Annual Meeting of AACR, San Francisco 2000. 100. Lee, W-N. P., S. Bassilian, S. Lim and L. G. Boros. 2-Deoxyglucose inhibits both oxidative and non- oxidative branches of the pentose cycle. Presented at the Annual Meeting of FASEB, San Diego, 2000 101. Lee, W-N.P. S. Lim, S. Bassilian, L. G. Boros, and M. Cascante. The role of transketolase in glycogen synthesis in HepG2 cells. Diabetes 49 (suppl 1): A424, 2000. 102. Kurland I. J., A. A. Alcivar, S Bassilian and W. P. Lee. Loss of 13C carbon via the pentose cycle in gluconeogenesis. Diabetes 49 (suppl 1): A273, 2000. 17
  18. 18. 103. Mao, C.S., Bassilian, S., Lim, S.K. and W.N.P. Lee. Underestimation of gluconeogenesis by the U13C-glucose method: Effect of lack of isotope equilibrium. Presented at the Annual Meeting of Endocrine Society, Toronto, 2000. 104. Comin, B, Boren J, Moro C, Martinez, S, Lee, WNP, Boros LG, Centelles JJ and Cascantes M. New antitumoral drugs based on ribose phosphate synthesis tested by metabolic control analysis. Presented th at the 18 International Congress of Biochemistry and Molecular Biology, Manchester, England, 2000. 105. Boros, L.G., P. W-N. Lee and V.L.W. Go. Metabolic targets of tumor growth inhibitory signals in MIA pancreatic adenocarcinoma cells: A metabolic hypothesis of cellular signaling pathways. Presented at the Annual Meeting of the American Pancreatic Association, Chicago, 2000. 106. Boros, L.G., P. W-N. Lee, M. Hidvegi and V.L.W. Go. Metabolic effects of fermented wheat germ extract with anti-tumor properties in cultured MIA pancreatic adenocarcinoma cells. Presented at the Annual Meeting of the American Pancreatic Association, Chicago, 2000. 107. Kurland, I. .J., J. Xu, M. Patel, S. Bassilian and W.N.P. Lee . Metabolic phenotypic differences between primary hepatocytes and Fao hepatoma cells. Annual Meeting of WSCR, 2001 108. Baik, S. H., K. Trinh, A. Yao, F. Hernandez, H. Mahdavieh, A. Alcivar, C. Pelayo, J. Xu, I. Garcia, M. A. Raines, S. Bassilian, W. N. P. Lee and I. J. Kurland. Direct inhibition of glucose-6- phosphatase activity by phosphatidylinositol 3-kinase (pI3-kinase) pathway in Fao cells. Presented at the Annual Meeting of WSCR, 2001 109. Boros, LG, WP Lee and RD Williams. Isofenphos organophosphate pesticide induces metabolic changes of the invasive phenotype in k562 myeloid blast cells. Presented at the Annual Meeting of WSPR, 2001. 110. Lee, W-N. P., C.S. Mao, S Bassilian, S Lim, S Ahmed and LG Boros. Plasma fatty acid production and the role of de novo lipogenesis in energy transport. Presented at the Annual Meeting of WSPR, 2001. 111. Boros, LG, J Boren, S Marin, M Cascante, S Lim, S Bassilian, A Syed and W-N P Lee. STI571 decreases glucose derived nucleic acid synthesis but increases direct glucose oxidation in K562 myeloid blast cells. Presented at Annual Meeting of AACR, New Orleans, 2001. 112. Lee, W-N. P., S. Lim, S. Bassilian, S. Ahmed, C.S. Mao and L. G. Boros. Glucose Metabolic Changes In HepG2 Cells Induced by the Glycogen Phosphorylase Inhibitor (CP-329,626). EB2001, Orlando, 2001. 114. Rehan, V., Feng, S., Rehan, Y.H., Lee, W-N.P., Torday, J.S., Boros, L.G., Evidence for metabolic phenotype changes during trans-differentiation of pulmonary lipofibroblasts to myofibroblasts in response to hyperoxia. Pediatric Academic Societies Annual Meeting, Baltimore, MD, April-May, 2001 114. Baik, S. H., K. Trinh, F. Hernandez, C. Pelayo, J. Xu, S. Bassilian, A. Alcivar, I. Garcia, M. Saad, M. A. Raines, W. N. P. Lee and I. J. Kurland. Coordinated changes in flux between the gluconeogenic and pentose pathways in Fao hepatoma cells via PI3-K inhibition of glucose-6- phosphatase. Diabetes 50 (suppl 2): A286, 2001. 115. I. J. Kurland, J. Xu, M Patel, A Ashok, S. Bassilian, M Saad and W. N. P. Lee. Age related changes in gluconeogenic and glycerol flux. Diabetes 50 (suppl 2): A332, 2001. 116. Marin S., Lee, WNP, Bassilian, S., Ahmed, S, Boros, LG, Centelles, J., Fernandez, JM, Cascante, M. Glucose Paradox II. Presented at the Annual Meeting of FEBS, Lisbon, Portugal, July 2001. 117. Boros, L.G., Syed, A.S., Bassilian S., Lim, S., Lee, W-N.P. Lack of proliferative and metabolic response in MIA pancreatic adenocarcinoma cell cultures after pharmacological doses of STI571 (Gleevec). Presented at American Pancreatic Association, Chicago, Illinois, November, 2001. 18
  19. 19. 118. Boros, L.G., Go, V.L., Lee, W-N.P. Metabolic Profiling of Cell Growth and Death in Cancer. Presented at the Cambridge Healthtech Institute’s Premier Conference on Metabolic Profiling: Pathways to Discovery (Invited presentation, keynote address), Sheraton Chapel Hill Hotel, Chapel Hill, North Carolina, December 4, 2001. 119. Kurland I.J., J. Xu,G. Xiao, C. Pelayo,. F. Hernandez, A. Alcivar, B. Chung, S. Bassilian, M. Saad, W.N.P. Lee. Metabolic flux analysis using 13C mass spectrometry for the investigation of hepatic insulin signaling. (Invited presentation) Pathways in Discovery Conference, Chapel Hill, NC, December 3-4, 2001. 120. Mao, C.S., S. Ahmed, Bassilian, S. and W.N.P. Lee. Modeling of U13C-glucose infusion: the role of lactate priming. Presented at WSPR, Carmel, CA, February, 2001. 121. Boros, L.G., Bassilian S., Lim, S., Lee, W-N.P. STI571 (Gleevec) inhibits de novo palmitate but does not affect nucleic acid synthesis in MIA pancreatic adenocarcinoma cells. Presented at WSPR, Carmel, CA, February, 2001. 122. Lee, WNP, S. Lim, S. Bassilian and L. G. Boros. Autoregulation of Fatty Acid β-Oxidation in HepG2 Cells. Presented at EB2002, New Orleans, LA, 2002. 123. Kurland, I.J., J. Xu, G. Xiao, C. Trujillo, V. Chang, L. Blanco, B. Strem, B. Chung, S. Ahmed, S. Bassilian, M. Saad and W.N.P Lee. A 1,2-13C glucose tolerance test for the assessment of hepatic pentose cycle flux and glucose re-cycling. Presented at EB2002, New Orleans, LA, 2002. 124. Boros, L.G, Deng, Q., Pandol, S.J., Tsukamoto, H, Go, V.L.W., Lee, W-N.P. Ethanol induced tissue specific lipotoxicity in the liver and pancreas. Presented at the American Gastroenterological Association, San Francisco, CA, 2002. 125. Xu, J., Collins, A., Trujillo, C., Lane, J., Xiao, G., Chang, V., Blanco, L., Bassilian, S., Saad, M., Lee, W-N. P. and Kurland, I. J. Decrease in pentose phosphate cycle flux precedes the development of age-related glucose intolerance. Presented at the Annual Meeting of the American Diabetes Association, San Francisco, 2002. 126. Kurland, I. J. , Xu, J., Xiao,G., Trujillo, C., Chang, V., Blanco, L., Chung, B. Collins, A., Bassilian, S., Saad, M., Tontonoz, P. and Lee, W-N. P. PPAR alpha Determines Gluconeogenic Substrate Utilization: A Glucose Metabolome Study of the PPAR alpha Null Mouse. Presented at the Annual Meeting of the American Diabetes Association, San Francisco, 2002. 127. Kurland, I. J. , Xu, J., Xiao,G., Bodnar J., Sheth S., Trujillo, C., Ocampo L., Chang V., Blanco L., Bassilian, S., Saad, M., Lusis J., and Lee, W-N. P. Accelerated Gluconeogenesis in a Familial Combined Hyperlipidemia (FCHL) Mouse Model: A Glucose Metabolome Study. Presented at the Annual Meeting of the American Diabetes Association, San Francisco, 2002. 128. Boros L.G., Q. Deng, S. Pandol, H. Tsukamoto, W-N. P. Lee. Ethanol induces tissue specific lipotoxicity in the liver and pancreas. Presented at the American Gastroenterology Association meeting 2002. 129. Lee WN P., L.G. Boros and CS Mao. Tracer Approaches to determining gluconeogenesis. Invited presentation, Nutrition Week 2003, San Antonio, TX, 2003. 130. Xu J, Chang, V., Joseph S.B., Bassilian, S., Saad, M., Lee, W-N. P. and Kurland, I. J. PPAR alpha affects pathways of gluconeogenesis from glycerol. Presented at EB2003, San Diego, CA, 2003. 131. Lee, WNP, S. Lim, S. Bassilian, L. G. Boros and T. Chao. Use of Asparagine as a Substitute for Glutamine in Cell Cultures. Presented at EB2003, San Diego, CA, 2003. 132. Xu, J., W.N.P. Lee, G. Xiao, C. Trujillo, V. Chang, L. Blanco, F. Hernandez, B. Chung, S. Makabi, S. Bassilian, M. Saad, I.J. Kurland. Glucose futile re-cycling is dependent on glucose concentration. Presented at WSPR, Carmel, CA, 2003. 19
  20. 20. 133. Tucker C., L.G. Boros, J. Santos, S. Bassilian, J. S. Torday, W-N. P. Lee, V. Rehan. Differential effects of vitamin-D3 on metabolic profiles of near term rat fibroblasts and type II cells in the lungs. Presented at WSPR, Carmel, CA, 2003. 134. Xu J, Chang, V., Joseph S.B., Bassilian, S., Saad, M., Lee, W-N. P. and Kurland, I. J. Evaluation of peripheral vs. hepatic insulin resistance in the PPARα KO mouse by IPGTT. Presented at Keystone Conference, Keystoine, Colorado, February 2003. 135. Xu, J., Xiao, G. , Baik, S., Alcivar, A., Hernandez, F., Pelayo, C., Chang, V., Blanco, L., Bassilian, S., Saad, M., Lee, W.N.P. and Kurland, I.J. ‘Integration of metabolic flux, protein and mRNA expression profiling for elucidation of hepatic insulin action: the Fao hepatoma PI3-Kinase action profile.’ Poster presented at the NIH sponsored meeting, Proteomics in Diabetes, April 23-25, 2003. 136. Xu J, Lee, W-N. P., Saad, M.F., Rueu K. and Kurland, I. J. Contribution of Hepatic Futile Cycling to Glucose Intolerance in the Lipin Defective fld Mouse. Presented at the Annual Meeting of the American Diabetes Association, New Orleans, LA, 2003. 137. Xu J, Xiao G., Baik S., Chang, V., Alcivar A., Hernandez F., Bassilian, S., Saad, M., Lee, W-N. P. and Kurland, I. J. Coordination of Molecular Mechanisms of Insulin Action that Affects Hepatic Gluconeogenic and Pentose Cycle Flux. Presented at the Annual Meeting of the American Diabetes Association, New Orleans, LA, 2003. 138. Xu, J., Chang, V., Joseph, S.B., Saad, M.F., Lee, W.N.P., and Kurland, I.J.. Metabolomic flux profiling: Use of steady state and dynamic [13C] glucose tolerance tests to evaluate peripheral vs. hepatic insulin action in the PPARa KO mouse. Poster presented at for the NIH sponsored meeting, Metabolic Profiling, May 14-15, 2003. 139. Lee, WNP. Developing Risk Reduction Strategies through Metabolic Profiling. Invited presentation. Presented at Metabolic Profiling: Application to Toxicology and Risk Reduction, An International Conference Research Triangle Park, North Carolina, May 14-15, 2003. 140. Xu, J., V. Chang, S.B. Joseph, Trujillo, S. Bassilian, M. Saad, W.N.P. Lee, and I.J. Kurland. Evaluation Of Hepatic Vs. Peripheral Insulin Resistance By Intraperitoneal Stable-Isotope-Glucose Tolerance Test. Presented at WSPR, Carmel, CA, February, 2004. 141. Vizan, P., L. G. Boros, S. Bassilian, S. Lim, M. Cascante, W-N. P. Lee. K-Ras Codon Mutations Induce Specific Substrate Flow Changes In The Metabolome Of Transfected Fibroblasts. Presented at WSPR, Carmel, CA, February, 2004. 142. Xu, J., V. Chang, C. Trujillo, S.B. Joseph, B. Vaitheesvaran, S. Bassilian, M. Saad, W.N.P. Lee, and I.J. Kurland. Glucose Metabolic Compensations To Reduced Energy Production From Β-Oxidation In PPARα KO Mouse. Presented at Keystone Symposium, Santa Fe, NM, March, 2004. 143. Boros LG. and WNP. Lee. An Industry Scale Model of High Throughput Profiling of the Glucose Metabolic Network Using the [1,2-13C2]-D-Glucose Single Tracer and GC/MS. Presented at Keystone Symposium, Santa Fe, NM, March, 2004. 144. Xu, J., W.N.P. Lee, P. Xu, C. Trujillo, S. Bassilian, M. Saad, K. Reue, and I. J. Kurland. Lipin coordinates the responsiveness of hepatic fatty acid synthesis and muscle glucose/fatty acid utilization to re-feeding. Presented at Keystone Symposium, Banff, Canada, April, 2004. 145. Lee W-N. P., S. Lim, S. Lee, S. Bassilian, L. G. Boros and D. Wong. Evidence for Altered β- oxidation in Fibroblast in Culture From Refsum’s Disease. Presented at EB2004, Washington DC, April 2004. 146. Garg M, C Bell, L Rogers, S Bassilian, and W.N. P. Lee. Role Of De Novo Lipogenesis In Growing Low Birth Weight Breast-Fed Infant. Presented at Pediatric Academic Societies Meeting, San Francisco, May 2004. 20
  21. 21. 147. Garg M, M. Thamotharan, S. Thamotharan, Samuel Lee, S Bassilian, W.N. Paul Lee, SU Devaskar. Maturation of glucose regulatory mechanisms: Effect of prenatal and postnatal nutrient restriction. Presented at Pediatric Academic Societies Meeting, San Francisco, May 2004. 148. Tony Lee, Owen Mcguinness, Fuyu Chueh, W.N.Paul Lee and Irwin J. Kurland. Euglycemic- hyperinsulinemic (EU-HI) clamp limitations for assessment of high fat induced hepatic insulin resistance in the mouse. Presented at the Annual Meeting of the American Diabetes Association, Orlando, June 2004. 149. Wong D. A., Bassilian S., Boros L., W-N. P. Lee. Increased long chain fatty acid synthesis in SCAD deficient mice. Presented at the Annual Meeting of the American Society of Human Genetics, 2004. 150. Wong DA, S Bassilian, S Lim, W-N. P. Lee. A metabolomic analysis of very long chain fatty acid synthesis in control and refsum fibroblasts. Presented at the WSPR meeting 2005 151. Lee WNP, S Marin, S Bassilian, S Lim, LG Boros, M Cascante. Effect of glucose-6-phosphatase and glucokinaseoverexpression on hexose phosphate fluxes. Submitted to EB2005, San Diego, 2005. 152. JYee, S Lim, CS Mao, WN P Lee. Regulation of fatty acid composition by SCD1 systems in HepG2 cells Presented at the WSPR meeting 2007 153. JK Yee, S Lim, CS Mao, S Sugano, VK Rehan, G Xiao, WN P Lee Compartmentalization of stearoyl-CoA desaturase enzyme 1 systems In HepG2 cells. Accepted for presentation at Pediatric Academic Societies Meeting Toronto, 2007. 154. Jennifer K Yee, Shu Lim, Catherine S Mao, S Sugano, Verender K Rehan, Gary Xiao, WN Paul Lee Inhibition of stearoyl-CoA desaturase enzyme alters oleate turnover In NIH3T3 Preadipocytes. Accepted for presentation at American Diabetes Association Meeting, 2007. 155. Yee JK, Lim S, Desai M, Ross M, Lee WNP. Role of Stearoyl-CoA Desaturase in Prenatal Nutritional Programming of Adult Obesity in Rats. Presented at the WSPR meeting, February 2008. 156. Meena Garg, M. Thamotharan, Paul WN Lee, and Sherin U. Devaskar. Early Intervention with a Peroxisome Proliferator-Activated Receptor (PPAR) Agonist Improves Insulin Sensitivity in the Pre- Gestational Adult IUGR Offspring. Presented at Pediatric Academic Societies Meeting Honolulu, Hawaii, May 2008. 157. M. Garg, M. Thamotharan, W.N. Paul Lee and S.U. Devaskar. Early Postnatal Caloric Restriction Reverses Obesity and Glucose Intolerance in the Aging Intra-Uterine Growth Restricted Male Offspring. Presented at Pediatric Academic Societies Meeting Honolulu, Hawaii, May 2008.155. Yee JK, Lim S, Desai M, Ross M, Lee WNP. Role of Stearoyl-CoA Desaturase in Prenatal Nutritional Programming of Adult Obesity in Rats. Presented at the WSPR meeting, February 2008. 158. Xiao G, Ferreri K, Scott S, Lim S, Go VL, Lee WNP. Glucose Utilization by Alpha and Beta Cells of Isolated Islets from Rats: A Proteomics Study. Submitted to American Diabetes Association Annual Meeting, 2008. 159. Yee JK , Lim S, Mao CS, Lee WNP. Inhibition Of Stearoyl-CoA Desaturase Enzyme Decreases Adipocyte Differentiation In NIH3T3 Preadipocytes. Submitted to American Diabetes Association Annual Meeting, 2008. 160. Zhao Y, Lee WNP, Lim S, Xiao J, Recker RR, Xiao GG. Measuring Protein Synthesis as Part of Proteomics Study on Pancreas Cancer Cell Proliferation. Presented at the Annual Meeting of ASMS, June 2008. 161. Xiao J, Lee WNP, Lim S, Zhao Y, Recker RR, Xiao GG. Biomarker discovery using low enrichment of stable isotope. Presented at the Annual Meeting of ASMA, June 2008. 21

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