Curriculum Vitae

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Curriculum Vitae

  1. 1. Updated 5/29/08 Curriculum Vitae Cheryl Frye Personal Information Professional Contact Info 48 Brookline Avenue (518) 591-8839 voice Albany, NY 12203 (518) 591-8848 fax Dob: 5/5/66, US Citizen cafrye@albany.edu Married: 3 children (Jeffrey-6, Vincenzo 4, Luciana 1) Life Sciences 1058 EDUCATION Boston University 1993-1995 Department of Biology NRSA Post-doc, Neuroendocrinology Tufts University 1988-1992 Psychology Department M.S., Ph.D., Behavioral Neuroscience Wheaton College 1984-1988 Biopsychology Department A.B., cum laude, Biopsychology POSITIONS, EMPLOYMENT, & HONORS The City of Albany School District, Founder Award 2008 The University at Albany, SUNY, Research Excellence Award 2007 The City of Albany School District, Volunteer Award 2008 The University at Albany, SUNY, Professor of Psychology 2006-present The University at Albany, SUNY, Associate Professor of Psychology 2000-2006 The Society for Neuroscience, Faculty for Undergraduate Neuroscience, Educator of the Year 2003 The University at Albany, SUNY, Institute for Health & the Environment 2003-present The University at Albany, SUNY, Adjunct Professor of Biological Sciences 1998-present The University at Albany, SUNY, Member, Neuroscience Research Center 1998-present The University at Albany, SUNY, Assistant Professor of Psychology 1998-2000 The University of Hartford, Department of Biology, Adjunct Professor 1998-2000 Connecticut College, Assistant Professor of Psychology & Zoology , Director of Neuroscience 1995-1998 Wheaton College, Department of Psychology, Visiting Assistant Professor 1994-1995 Boston University, Department of Biology, NIH Post-doctoral Fellow 1993-1995 Bates College, Departments of Psychology & Biology, Visiting Assistant Professor 1992-1993 Wheelock College, Department of Human Development, Instructor 1990-1992 Tufts University, Department of Psychology, TA, RA, Instructor 1988-1992 Boston University, Department of Biology, NSF REU Awardee 1987-1988 Wheaton College, Department of Psychobiology, Research Assistant 1986-1987 Harvard Medical School, Department of Urological Research, Laboratory Technician 1985-1986
  2. 2. OTHER PROFESSIONAL EXPERIENCE NIH Special Emphasis Review Panel: Behavioral Neuroscience 2008-present NIH Special Emphasis Review Panel: Minority Undergraduate Biomedical Education Program 2006-2007 NIH Special Emphasis Review Panel: The CNS as a Target of Steroid Hormones 2005-2006 NIH Special Emphasis Review Panel: Androgens and Aging 2004-2005 NIH Special Emphasis Review Panel: Women’s Health Initiative 2004-2005 NIH Special Emphasis Review Panel: COBRE 2004-2005 NIH Special Emphasis Review Panel: Mechanisms of Stress 2003-2004 NIH Special Emphasis Review Panel - Improving Minority Research Opportunities 2000-2001 American Academy of Neurology, Neuroendocrine Section 2000-present Biocontinuum Group (Provides Continuing Medical Education to Neurologists) 2004-present Editorial Board, Brain Research 2002-present Editorial Board, Physiology & Behavior 2001-present North East Under/graduate Research Organization for Neuroscience, Founder & Director 1997-present Research Experience for Undergraduate SUNY Summer Program, Co-Founder & Director 2000-2004 International Pharmacology, Biochemistry, & Behavior Conference, Advisory Board 2003-present International Steroids & Nervous System Conference, Advisory Board 2002-present Ad hoc Grant Reviewer: (partial list) Alzheimer’s Association, Burroughs-Welcome Trust. Epilepsy Foundation of America National Science Foundation and its equivalent agencies in Canada, France, and Switzerland Ad hoc Reviewer of Publications: (partial list) Archives of Medical Research, Behavioral Brain Research, Behavioral Neuroscience, Endocrinology, Hormones & Behavior, Journal of Neuroendocrinology, Neuropsychopharmacology, J. Neuroscience, Pharmacology, Biochemistry & Behavior, Psychoneuroendocrinology, Psychopharmacology GRANT SUPPORT-ACTIVE “Progestins’ non-genomic actions for sex behavior” Total Costs: $1,146,075 Proposal Number: MH06769801 Annual Direct: ~$150,000 PI: Cheryl A. Frye, Ph.D. Agency: NIMH, Type: R01 Dates of Project: 7/1/04-6/30/09 Percent Effort: Academic Year 20%, Summer 75% To delineate mechanisms, sources, and effects of progestins underlying appetitive aspects of mating behavior in rats. “Non-genomic actions of progestins in the VTA for lordosis” Total Costs: $370,000 Project Number: IBN-0316083 Annual Direct: $80,000 PI: Cheryl A. Frye, Ph.D. Agency: NSF Dates of Project: 9/1/03-8/31/08 Percent Effort: Academic Year 0%, Summer 25% The major goals of this project are to investigate progestins’ actions, via signal transduction pathways, to mediate consummatory aspects of mating, lordosis, of female rodents. “Mechanisms of estrogen and selective estrogen receptor modulators to reduce anxiety and depression behavior, without proliferative effects, in a menopausal model” Total Costs: $90,000 Sponsor: Cheryl A. Frye, Ph.D. Annual Direct: $27,000 Trainee: Alicia Walf Agency: Department of Defense, Pre-doctoral Grant Dates of Project: 6/1/06-5/31/09 Percent Effort: Academic Year 0%, Summer 0% Goals are to investigate estrogen’s mechanisms to mediate affect concomitant with effects on cell 2
  3. 3. proliferation in breast and uterine tissues in female rodents. “Northeast Under/Grad Research Organization for Neuroscience” Total Costs: $102,309 Proposal Number: 2R13MH060282-06A2 Annual Direct: $34,103 P.I. Cheryl A. Frye, Ph.D. Agency: NIH, Type: Conference Grant Dates of Proposed Project: 4/1/06-3/31/11 Percent Effort: Academic 0%, Summer 3% This project is to support a student/faculty conference oriented to enhancing training of neuroscientists. “A drug contract to investigate behavior and trophic effects of some of their proprietary estrogens that have actions at estrogen receptor beta” Total Costs: $70,000, Annual Direct: $45,000 P.I. Cheryl A. Frye, Ph.D. Agency: KARIOBIOCHEM Type: Drug Contract Dates of Proposed Project: 3/1/08-2/28/11 Percent Effort: Academic 0%, Summer 20% This project is for drug development to establish more effective hormone replacement strategies. “The role of ERbeta in prostate cancer” P.I. Cheryl A. Frye, Ph.D. Total Costs:$60,000, Annual Direct: $60,000 Dates of Proposed Project: 9/1/08-8/31/09 Agency: KARIOBIOCHEM Type: Drug Contract Percent Effort: Academic 3%, Summer 6% The main goal of this project is to investigate ERbeta’s actions in andropause and the trophic effects of treatment on prostate tissues. PRIOR EXTRAMURAL SUPPORT “Actions of estrogen in the nucleus accumbens for conditioning” Total Costs: $30,000 Project Number: None Annual Direct: $30,000 PI: Cheryl A. Frye, Ph.D. Agency: Lilly Centre for Women’s Health Dates of Project: 6/1/03-5/31/04 Percent Effort: Academic Year 0%, Summer 0% The major goals of this project are to investigate estrogens' effects on conditioning and mechanisms in the nucleus accumbens. "NEURON: North East Under/graduate Research Organization for Neuroscience” Total Costs: $86,274 Project Number: MH06028206 PI: Cheryl A. Frye, Ph.D. Annual Direct: $17,250 Dates of Approved Project: 9/1/99-8/31/04 Agency: NIMH, Type: R13 Percent Effort: Academic Year 10%, Summer 0% The major goals of this project were to support a student/faculty conference oriented to enhanced training of neuroscientists. “Increasing U.S. Participation in 5th Pharmacology, Biochemistry, & Behavior Conference” Total Costs: $10,000 Project Number: pending Annual Direct: $10,000 PI: Cheryl A. Frye, Ph.D. Agency: NSF, Type: Conference Grant Dates of Approved Project: 4/1/04-3/31/04 Percent Effort: Academic Year 0%, Summer 0% The goal of this funding was to provide pedagogical resources and tangible support for senior investigators and trainees from the U.S.
  4. 4. “A summer program in neuroscience at SUNY-Albany” Total Costs: $304,200 Project Number: DBI-0097343 Annual Direct: $90,000 PI: Gregory Lnenicka, Ph.D. Agency: NSF, Type: REU co-PI: Cheryl A. Frye, Ph.D. Dates of Approved Project: 4/1/01-3/31/04 Percent Effort: Academic Year 0%, Summer 0% The major goal of this project was to provide undergraduates neuroscience research experience with a SUNY-Albany faculty member. “Increasing U.S. Participation- International Conference on Steroids and Brain” Total Costs: $15,000 Project Number: IBN-0242546 Annual Direct: $15,000 PI: Cheryl A. Frye, Ph.D. Agency: NSF, Type: Conference Grant Dates of Approved Project: 3/1/03-2/29/04 Percent Effort: Academic Year 0%, Summer 0% The goal of this funding was to provide pedagogical resources and tangible support for senior investigators and trainees from the U.S. “Neurosteroids effects on sexual receptivity” Amount: $539,003 PI: Cheryl A. Frye, Ph.D. Agency: NSF Type: CAREER Grant Period: 2/1/96-8/31/03 Investigated actions of progestins via GABAA receptors to mediate lordosis of female rodents. “Effects and Mechanisms of Progestins' Modulation of Seizure Activity” Total Costs: $16,000 Project Number: None Sponsor: Cheryl A. Frye, Ph.D. Annual Direct: $16,000 Trainee: Madeline E. Rhodes Agency: Epilepsy Foundation of America, Type: Ph.D. Fellowship Dates of Approved Project: 7/01/2003-6/30/2004 Percent Effort: Academic Year 0%, Summer 0% The major goal of this project was to investigate progestins’ mechanisms in the hippocampus to mediate ictal activity in a rodent model. “Effects of PDE Inhibitors in an animal model of female sexual dysfunction”Amount: $50,000 PI: Cheryl A. Frye, Ph.D. Agency: Eli Lilly, Inc. Type: Contract Period: 1/1/00-1/1/01 Screened potential therapeutics to determine effects on female sexual responsiveness in hamsters. This contact was an essential part of the development and/or approval of the drug Cialis. “Neurosteroids’ role in cognitive, affective, & neurodegenerative disorders" Amount: $90,000 PI: Cheryl A. Frye, Ph.D. Agency: Whitehall Foundation Type: Grant-in-Aid Period: 6/1/96-5/31/00 Investigated neurosteroids role in cognitive and affective behavior and neurodegenerative disorders. “Neurosteroids’ role in epilepsy” Amount: $180,000 PI: Cheryl A. Frye, Ph.D., co- PI: Dr. Jacob Harney Agency: Donaghue Fdn Type:Young Investigator Period: 6/1/96-8/31/00 Examined progestins' effects on ictal activity in animal models of catamenial epilepsy. “Progestins actions in the VTA for lordosis” Amount: $25,000 PI: Cheryl A. Frye, Ph.D. Agency: NIH Type: B-START 4
  5. 5. Period: 2/1/96-1/31/97 Although funded, declined award to pursue CAREER grant, which had overlapping research aims. “Androgens actions for inhibiting sexual receptivity” Amount: $83,000 Sponsor: Mary S. Erskine, Ph.D. Agency: NIMH Type: F32 Trainee: Cheryl A. Frye, Ph.D. Period: 1/1/93-8/31/95 Examined effects and mechanisms of androgenic neurosteroids to inhibit sexual receptivity in rodents. “Neurosteroids role in affect and cognition” Amount: $25,000 PI: Cheryl A. Frye, Ph.D. Agency: NSF Type: Research Planning Grant Period: 5/1/93-4/30/94 Although funded, declined award to pursue NRSA grant. PRIOR INTRAMURAL SUPPORT SOURCE TYPE TIME FUNDS SUNY-Albany Symposium Support Spring 2008 $500 SUNY-Albany Brain Awareness Week Support Spring 2008 $1,500 SUNY-Albany Conference Support Grant Spring 2008 $1,500 SUNY-Albany McNair Minority Student Support Summer 2004 $3,000 SUNY-Albany Research Incentive Award Summer 2004 $5,000 SUNY-Albany Conference Support Grant Spring 2004 $700 SUNY-Albany Affirmative Action Grant Summer 2003 $250 SUNY-Albany Research Incentive Award Summer 2003 $5,000 SUNY-Albany Affirmative Action Grant Summer 2002 $700 SUNY-Albany McNair Minority Student Support Summer 2002 $1,000 SUNY-Albany McNair Minority Student Support Summer 2001 $1,000 SUNY-Albany STAR Undergrad Research Grant October 2001 $1,000 SUNY-Albany Faculty Research Award Program February 2001 $10,000 SUNY-Albany Professional development Award January 2001 $800 SUNY-Albany Professional development Award May 1999 $1,000 SUNY-Albany Faculty Research Award Program December 1998 $10,000 SUNY-Albany Start-up Funds September 1998 $77,000 Connecticut College Johnson Fund 1995-1998 $4,300 Connecticut College Start-up Funds September 1995 $100,000 Bates College Howard Hughes Research Program Summer 1993 $3,500 Bates College Schmutz Grant for Faculty Research December 1992 $5,000 Bates College Start-Up Funds for 1 year September 1992 $5,000 Appointment Tufts University Dissertation Research Grant February 1991 $1,500
  6. 6. PRIOR SMALL GRANTS SOURCE TYPE TIME FUNDS NIH Microarray Consortium Spring $6,000 2008-2009 NIH Microarray Consortium Spring $6,000 2008-2009 NIH Microarray Consortium Spring $6,000 2008-2009 NIH Microarray Consortium Summer $6,000 2007-2008 NIH Microarray Consortium January 2008 $11,150 Harvard Pilgrim NEURON mentoring project Fall 2007-2008 $500 Health Care NIH Microarray Consortium January 2007 $3150 Epilepsy F’dation Summer Fellowship April 2000 $2,000 Endocrine Society Summer Fellowship April 1999 $2,500 Parkinsons F’dation Summer Fellowship February 2001 $900 Sigma Xi Grant-in-Aid March 1991 $750 Sigma Xi Grant-in-Aid August 1990 $800 Sigma Xi Grant-in-Aid March 1989 $600 PRIOR TRAVEL GRANTS SOURCE TYPE TIME FUNDS SUNY-Albany Travel Grant Spring 2008 $1,500 NIAAA Travel Grant September 2006 $1,500 SUNY-Albany Faculty Travel Award January 2006 $900 SUNY-Albany Faculty Travel Award February 2003 $900 ACNP Young Investigator Fellowship January 2002 $2,000 Neurobio Epilepsy Young Investigator Fellowship May 2001 $1,500 SUNY-Albany Faculty Travel Award February 2001 $900 SUNY-Albany Faculty Travel Award May 2000 $850 WCBR Post-Doc Travel Award January 1994 $1,500 Workshop Steroids Post-Doc Travel Award March 1993 $1,200 REFEREED-PUBLICATIONS 181. Frye, C.A., Walf, A.A. (2008). Progesterone to ovariectomized mice enhances cognitive performance in the spontaneous alternation, object recognition, but not placement, water maze. Neurobiol Learn Mem. (in press). 180. Ryan, A, Frye, C.A. (2008). Antiseizure effects of 5alpha-androstane-3alpha,7beta-diol may be independent of actions at estrogen receptor beta. Epilepsy Behav. (in press). 179. Frye, C.A., Walf, A.A. (2008). Progesterone enhances performance of aged mice in cortical or hippocampal tasks. Neurosci Lett. (in press). 6
  7. 7. 178. Frye, C.A., Walf, A.A. (2008). Effects of manipulating progesterone and NMDA receptors in the ventral tegmental area and lordosis of hamsters and rats. Psychopharmacology (in press). 177. Frye, C.A., Walf, A.A. (2008). Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways. Steroids (in press). 176. Walf, A.A., Frye, C.A. (2008). Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen. Steroids (in press). 175. Frye, C.A., Sumida, K.A., Unger, M.S. (2008). Progesterone reduces depressive behavior of young and aged progestin receptor knock out mice in the tail suspension test. Journal of Psychopharmacology (in press). 174. Walf, A.A., Koonce, C., Frye, C.A. (2008). Adult female wildtype, but not estrogen receptor β knockout, mice have decreased depression-like behavior during proestrus and following administration of estradiol or diarylpropionitrile. Journal of Psychopharmacology. (in press). 173. Walf, A.A., Frye, C.A. (2008). Conjugated equine estrogen enhances rats’ cognitive, anxiety, and social behavior. Neuroreport, 19, 789-792. 172. Walf, A.A., Koonce, C., Frye, C.A. (2008). Estrogen or diarylpropionitrile administration to wildtype, but not estrogen receptor β knockout, mice enhance performance in the object recognition and object placement tasks. Neurobiology of Learning and Memory. 89, 513-521. 171. Frye, C.A., Sumida, K., Edinger, K.L. (2008). Androgen administration to aged male mice increases anti- anxiety behavior and enhances cognitive performance. Neuropsychopharmacology 33, 1049-1061. 170. Frye, C.A., Walf, A.A. (2008). Effects of progesterone administration and APPswe+PSEN1∆e9 mutation for cognitive performance of mid-aged mice. Neurobiology of Learning and Memory 89, 17-26. 169. Frye, C.A. & Rhodes, M.E. (2008). Infusions of 3α,5α-THP to the VTA enhance exploratory, anti- anxiety, social, and sexual behavior and increase levels of 3α,5α-THP in midbrain, hippocampus, diencephalon, and cortex of female rats. Behavioral Brain Research 187, 88-99. 168. Walf, A.A. & Frye, C.A. (2008). Parity and estrogen-administration alters anxiety and depression behavior of ovariectomized rats. Physiology & Behavior 93, 351-356. 167. Walf, A.A, Ciriza, I., Garcia-Segura, L.M.., Frye, C.A. (2008). Antisense oligodeoxynucleotides for estrogen receptor β and α attenuate estradiol's modulation of affective and sexual behavior, respectively. Neuropsychopharmacology 33, 431-440. 166. Edinger, K.L., Frye, C.A. (2007). Sexual experience of male rats influences anxiety-like behavior and androgen levels. Physiology and Behavior 92: 443-53. 165. Frye, C.A., Walf, A.A. (2007). In the ventral tegmental area, the membrane-mediated actions of progestins for lordosis of hormone-primed hamsters involve phospholipase C and protein kinase C. Journal of Neuroendocrinology 19, 717-724. 164. Walf, A.A., Duffy, C.K. Frye, C.A. (2007).Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task. Neurobiol Learn Mem. 88(2):208-216 163. Walf, A.A., Frye, C.A. (2007). The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nature Protocols 2:322-328. 162. Frye,C.A., Paris, J.J. & Rhodes, M.E. (2007). Engaging in paced mating, but neither exploratory, anti- anxiety, nor social behavior, increases 5α-reduced progestin concentrations in midbrain, hippocampus, striatum and cortex. Reproduction 1133:663-674. 161. Walf, A.A., Frye, C.A. (2007). Estradiol decreases anxiety behavior and enhances inhibitory avoidance and gestational stress produces opposite effects. Stress 10:251-260.
  8. 8. 160. Petralia, S.M., Debold, J.F., Frye, C.A. (2007). MK-801 Infusions to the VTA and VMH produce opposite effects on lordosis of hormone-primed rats. Pharmacology, Biochemistry, and Behavior 86, 377-385. 159. Frye, C.A., Babson, A., Walf, A.A., (2007). Self-Administration of 3α-Androstanediol increases anti- anxiety behavior and decreases aggressive behavior of male hamsters. Pharmacology, Biochemistry, and Behavior 86, 415-421. 158. Walf, A.A., Frye, C.A. (2007). Administration of estrogen receptor β selective estrogen receptor modulators to the hippocampus decrease anxiety and depressive behavior of ovariectomized rats. Pharmacology, Biochemistry, and Behavior 86, 407-414. 157. Frye, C.A. (2007). Some rewarding effects of androgens may be mediated by actions of its 5α-reduced metabolite 3α–Androstanediol. Pharmacology, Biochemistry, and Behavior 86, 354-367. 156. Frye, C.A. (2007). Progestins influence motivation, reward, conditioning, stress, and/or response to drugs of abuse. Pharmacology, Biochemistry, and Behavior 86, 209-219. 155. Frye, C.A, & Rhodes, M.E. (2007). Infusions of 5α-pregnan-3α-ol-20-one (3α,5α-THP) to the ventral tegmental area, but not the substantia nigra, enhance exploratory, anti-anxiety, social and sexual behaviours and concomitantly increase 3α,5α-THP concentrations in the hippocampus, diencephalon and cortex of ovariectomised oestrogen-primed rats. Journal of Neuroeondocrinology 18, 960-75. 154. Edinger, K.L., Frye, C.A. (2007). Androgens' effects to enhance learning and memory may be mediated in part through actions at estrogen receptor-β in the hippocampus. Neuroiology Learning and Memory 87, 201-8. 153. Petralia, S.M., Walf, A.A., Frye, C.A. (2006). In the ventral tegmental area, progestins’ membrane-mediated actions for lordosis of hamsters and rats involve protein kinase A. Neuroendocrinology 84, 405-414. 152. Petralia SM, Frye CA. (2006) In the ventral tegmental area, cAMP mediates progesterone’s actions at dopamine type 1 receptors for lordosis of rats and hamsters. Journal of Neuroendocrinology 18, 902-14. 151. Herzog, A.G., Drislane, F.W., Schomer, D.L., Pennell, P.B., Bromfield, E.B., Dworetzky, B.A., Farina, E.L., & Frye, C.A. (2006). Differential effects of antiepileptic drugs on neuroactive steroids in men with epilepsy. Epilepsia 47, 1945-8. 150. Edinger, K.L, Frye, C.A. (2006). Androgens' cognitive-enhancing effects may involve actions at intracellular androgen receptors in the dorsal hippocampus. Neurobiology of Learning and Memory 50, 216-22 149. Frye, C.A., Walf, A.A., Petralia, S.M. (2006). Progestin facilitation of lordosis in rodents involves adenylyl cyclase activity in the ventral tegmental area.. Hormones and Behavior 50, 237-44. 148. Frye, C.A, & Rhodes, M.E. (2006) Progestin concentrations are increased following paced mating in midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of diestrous rats. Neuroendocrinology 83, 336-47. 147. Ciriza, I., Carrero, P., Walf, A.A., Frye, C.A., Garcia-Segura, L.M. (2006). Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin mderoxyprogesterone acetate is not neuroprotective. Journal of Neurobiology 66, 916-28. 146. Frye, C.A., Walf, A.A.,, Petralia, S.M. (2006). Progestins’ effects on sexual behavior of female rats and hamsters involving D1 and GABAA receptors in the ventral tegmental area may be G-protein-dependent. Behavioral Brain Research 172, 286-293. 145. Frye, C.A., Walf, A.A., Petralia, S.M. (2006). In the ventral tegmental area, progestins have actions at D1 receptors for lordosis of hamsters and rats that involve GABAA receptors. Hormones andBehavior 50, 332-7. 144. Frye CA, Sumida K, Zimmerberg B, Brunelli SA. (2006). Differences in sexual behavior and midbrain 3α,5α-THP levels of adult rats bred for high-anxiety responses postnatally. Behavioral Neuroscience 120, 281-9. 8
  9. 9. 143. Walf, A.A., Rhodes, M.E., Meade, J., Harney, J.P., Frye, C.A. (2006). Estradiol-induced conditioned place preference may require actions at estrogen receptors in the nucleus accumbens. Neuropsychopharmacology 32, 522-530. 142. Frye. C.A., Sumida, K., Dudek, B.C., Harney, J.P., Lydon, J.P., O'Malley, B.W., Pfaff, D.W., Rhodes, M.E. (2006). Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors. Psychopharmacology 186, 312-22. 141. Walf, A.A., Rhodes, M.E., Frye, C.A. (2006). Ovarian steroids enhance object recognition in naturally- cycling and ovariectomized, hormone-primed rats. Neurobiology of Learning and Memory 86, 35-46. 140. Frye CA, Rhodes ME, Raol Y, Brooks-Kayal AR. (2006). Early postnatal stimulation alters pregnane neurosteroids in the hippocampus. Psychopharmacology 186, 343-50. 139. Smith, C.D., Wekstein, D.R., Markesbury, W.R., & Frye, C.A. (2006). 3α, 5α-THP: a potential plasma neurosteroid biomarker in Alzheimers Disease. Psychopharmacology 186, 481-485. 138. Frye, C.A. (2006). The role of androgens in epilepsy. Expert Review of Neurotherapeutics 6, 7:1061-1076. 137. Frye, C.A., Walf, A.A, Petralia, S.M. (2006). Progestin facilitation of lordosis in rodents involves adenylyl cyclase activity in the ventral tegmental area. Hormones and Behavior 50, 332-337. 136. Edinger, K.L., Frye C.A. (2006). Intrahippocampal administration of an androgen receptor antagonist, flutamide, can increase anxiety-like behavior in intact and DHT-replaced male rats. Hormones and Behavior 50, 216-220. 135. Walf, A.A., Sumida, K., & Frye, C.A. (2006). Inhibiting 5α-reductase in the amygdala attenuates anti- anxiety and anti-depressive behavior of naturally-receptive and hormone-primed ovariectomized rats. Psychopharmacology 186, 302 134. Frye CA, Sumida K, Lydon JP, O’Malley BW, Pfaff, D. (2006). Mid-aged and aged wild-type and progestin receptor knockout (PRKO) mice demonstrate rapid progesterone and 3α,5α-THP-facilitated lordosis.. Psychopharmacology 186, 423-32. 133. Petralia SM, Frye CA. In the ventral tegmental area, G-proteins mediate progesterone’s actions at dopamine type 1 receptors for lordosis of rats and hamsters (2006). Psychopharmacology, 186(2):133-42. 132. Walf, A.A., Frye, C.A. (2006). A review and update: Estrogen’s effects, brain targets, and mechanisms for anxiety and depression behavior Neuropsychopharmacology, 31(6):1097-111. 131. Rhodes, M.E., & Frye, C.A. (2006). ERβ-selective SERM produce mnemonic-enhancing effects in the inhibitory avoidance and water maze tasks. Neurobiology Learning Memory, 85(2):183-91 130. Frye, C.A., Rhodes, M.E., Petralia, S.M., Walf, A.A., Sumida, K., & Edinger, K.L. (2006). 3α,5α-THP in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors. Neuroscience 138, 1007-14 129. Frye, C.A. (2006). An overview of contraceptives: Mechanism of action and clinical use. Neurology 66, S29-36 128. Frye, C.A, & Rhodes, M.E. (2006). Administration of estrogen to ovariectomized rats promotes conditioned place preference and produces moderate levels of estrogen in the nucleus accumbens. Brain Research 1067, 209-215. 127. Kellogg, C.K., Kenjarsk,i T.P., Pleger, G.L., Frye, C.A. (2006). Region-, age-, and sex-specific effects of fetal diazepam exposure on the postnatal development of neurosteroids. Brain Research 1067, 115-25. 126. Smith, S.S., Ruderman, Y., Frye, C., Homanics, G., Yuan, M..(2005). Steroid withdrawal in the mouse results in anxiogenic effects of 3α,5α-THP: a possible model of premenstrual dysphoric disorder. Psychopharmacology 29, 1-11.
  10. 10. 125. Herzog, A.G., Drislane, F.W., Schomer, D.L., Pennell, P.B., Bromfield, E.B., Dworetzky, B.A., Farina, E.L., & Frye, C.A. (2005). Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy. Neurology 65, 1016-20. 124. Frye, C.A., Rhodes, M.E. (2005) Estrogen-priming can enhance progesterone’s anti-seizure effects in part by increasing hippocampal levels of allopregnanalone. Pharmacology, Biochemistry, and Behavior 81, 907-16. 123. Rhodes, M.E., Talluri, J., Harney, J.P., & Frye, C.A. (2005). Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats. Epilepsy and Behavior 7, 231-9. 122. Frye, C.A., Harden, C.L., Baker, G. A., Montouris, G.D., Pennell, P.B., & Zupanc, M.L., eds. (2005). Effects of estrogen and progesterone on cortical excitations and epileptogenesis Neurology Supplement 121. Harden, C.L., Baker, G. A., Frye, C.A., Montouris, G.D., Pennell, P.B., & Zupanc, M.L., eds. (2005). Epilepsy through the menstrual cycle: the truth about catamenial epilepsy. Neurology Supplement 120. Harden, C.L., Baker, G. A., Frye, C.A., Montouris, G.D., Pennell, P.B., & Zupanc, M.L., eds. (2005). Correlations between hormone levels and seizure activity. Neurology Supplement 119. Frye, C.A., & Rhodes, M.E. (2005). Progesterone’s 5α-reduced metabolite, 3α, 5α-THP, mediates lateral displacement of hamsters. Brain Research, 1038(1): 59-68. 118. Frye, C.A., Rhodes, M.E., & Dudek, B.C. (2005). Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks. Brain Research, 1036(1-2); 101-8. 117. Petralia SM, Jahagirdar V, & Frye CA. (2005). Inhibiting biosynthesis and/or metabolism of progestins in the ventral tegmental area attenuates lordosis of rats in behavioural oestrus. J Neuroendocrinol., 17(9):545-52. 116. Petralia, S.M. & Frye, C.A. (2005). In the Ventral Tegmental Area, picrotoxin blocks FGIN-1-27-induced increases in sexual behavior of rats and hamsters. Psychopharmacology; 178(2-3):174-82. 115. Walf, A.A. & Frye, C.A. (2005). Antianxiety and antidepressive behavior produced by physiological estradiol regimen may be modulated by hypothalamic-pituitary-adrenal axis activity. Neuropsychopharmacology 2005;30(7):1288-301. 114. Sumida, K., Walf, A.A., Frye, C.A. (2005). Progestin-facilitated lordosis of hamsters may involve dopamine-like type 1 receptors in the ventral tegmental area. Behavioural Brain Research, 3;161(1):1-7. 113. Walf, A.A. and Frye, C.A. (2005). ER β-selective estrogen receptor modulators produce anti-anxiety behavior when administered systemically to ovariectomized rats. Neuropsychopharmacology, 30(9):1598-609. 112. Rhodes, M.E. & Frye, C.A. (2005). Attenuating 5α-pregnane-3α-0l-20-one formation in the hippocampus of female rats increases pentylenetetrazole-induced seizures. Epilepsy and Behavior, 6(2); 140-6. 111. Rhodes M.E. & Frye C.A. (2005). Actions at GABAA receptors in the hippocampus may mediate some of progestins’ anti-seizure effects. Epilepsy and Behavior, 6: 320-7. 110. Frye, C.A., Rhodes M.E., & Dudek B.C. (2005). Estradiol to aged male mice improves learning in inhibitory avoidance and water maze tasks. Brain Research, 1036: 101-8. 109. Zimmerberg, B., Brunelli, S. A., Fluty, A. J., Frye, C. A. (2005). Differences in affective behaviors and hippocampal allopregnanolone levels in adult rats of lines selectively bred for infantile vocalizations. Behavioral Brain Research, 159: 301-11. 108. Petralia, S.M. & Frye, C.A. (2004). In the Ventral Tegmental Area, G-proteins and cAMP mediate 3α,5α- THP’s actions at dopamine type 1 receptors for lordosis of rats. Neuroendocrinology, 80: 233-43. 107. Rhodes, M.E. & Frye, C.A. (2004). Progestins in the hippocampus of female rats have anti-seizure effects in a pentylenetetrazole seizure model. Epilepsia, 45: 1531-8. 106. Edinger, K.L. & Frye, C.A. (2004). Testosterone’s analgesic, anxiolytic, and cognitive-enhancing effects 10
  11. 11. may be due in part to actions of its 5α-reduced metabolites in the hippocampus. Behavioral Neuroscience, 118: 1352-64. 105. Herzog, A.G., Drislane, F.W., Schomer, D.L., Pennell, P.B., Bromfield, E.B., Kelly, K.M., Farina, E.L., Frye, C.A. Differential effects of antiepileptic drugs on sexual function and reproductive hormones in men with epilepsy: interim analysis of a comparison between lamotrigine and enzyme-inducing antiepileptic drugs. Epilepsia. 2004 45(7):764-8. 104. Frye, C.A. , Walf, A.A., & Sumida, K. (2004). Progestins’ actions in the VTA to facilitate lordosis involve dopamine-like Type 1 and 2 Receptors. Pharmacology, Biochemistry, & Behavior, 78: 405-418. 103. Rhodes, M.E. & Frye, C.A. (2004). Androgens in the hippocampus can alter, and be altered by, ictal activity. Pharmacology, Biochemistry, & Behavior, 78:483-493. 102. Frye, C.A & Edinger, K.L. (2004). Testosterone’s metabolism in the hippocampus mediates its anti-anxiety effects in male rats. Pharmacology, Biochemistry, & Behavior, 78: 473-481. 101. Edinger, K.L., Lee, B., & Frye, C.A. (2004). Mnemonic effects of testosterone and its 5α-reduced metabolites in the conditioned fear and inhibitory avoidance tasks. Pharmacology, Biochemistry, & Behavior, 78, 559-568. 100. Rhodes, M.E., McCormick, C.M., & Frye, C.A. (2004). 3α,5α-THP mediates progestins' effects to protect against adrenalectomy-induced cell death in the dentate gyrus of female and male rats. Pharmacology, Biochemistry, & Behavior, 78: 505-512. 99. Frye, C.A. and Walf, A.A. (2004). Hippocampal 3α,5α-THP may alter depressive behavior of pregnant and lactating rats. Pharmacology, Biochemistry, & Behavior, 78: 531-540 98. Walf, A.A., Rhodes, M.E., & Frye, C.A. and (2004). Anti-depressant effects of ERβ selective estrogen receptor modulators in the forced swim test. Pharmacology, Biochemistry, & Behavior, 78: 483-493. 97. Rhodes, M.E. & Frye, C.A. (2004). Estrogen has mnemonic enhancing effects in the inhibitory avoidance task. Pharmacology, Biochemistry, & Behavior, 78: 551-558. 96. Frye, C.A., Edinger, K.L.,Seliga, A.M., & Wawrzycki, J.M. (2004). 5α-reduced androgens may have actions in the hippocampus to enhance cognitive performance of male rats. Psychoneuroendocrinology, 29, 1019-1027. 95. Rhodes, M.E., Harney, J.P., & Frye, C.A. (2004). Gonadal, adrenal, and neuroactive steroids’ role in ictal activity. Brain Research, 1000 (1-2): 8-18. 94. Frye, C.A. and Walf, A.A. (2004). Estrogen and/or progesterone administered systemically or to the amygdala can have anxiety-, fear-, and pain-reducing effects in ovariectomized rats. Behavioral Neuroscience, 118, 306-13. 93. Frye, C.A., Walf, A.A., Rhodes, M.E., & Harney, J.P. (2004). Progesterone enhances motor, anxiolytic, analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5α-reductase. Brain Research, 1004, 116-124. 92. Frye, C.A. & Wawrzycki, J. (2003). Effect of prenatal stress and gonadal hormone condition on depressive behavior of female and male rats. Hormones and Behavior, 44, 319-326. 91. Frye, C.A. & Seliga, A.M. (2003).Effects of olanzapine infusions to the VTA on lordosis and midbrain 3α,5α-THP concentrations in rats. Psychopharmacology, 170, 132-139. 90. Frye, C.A., Petralia, S.M., Rhodes, M.E., & Stein, B. (2003). Fluoxetine may influence lordosis of rats through effects on midbrain 3α,5α-THP concentrations. Annals of the New York Academy of Science 1007, 37-41. 89. Walf, A.A. and Frye, C.A. (2003). Anti-nociception following exposure to trimethylthiazoline, peripheral or intra-amygdala estrogen and/or progesterone. Behavioural Brain Research 144(1-2), 77-85.
  12. 12. 88. Frye, C.A. & Seliga, A.M. (2003). Olanzapine's effects to reduce fear and anxiety and enhance social interactions coincide with increased progestin concentrations of ovariectomized rats. Psychoneuroendocrinology, 28(5), 657-673. 87. Frye, C.A. & Petralia, S.M. (2003). Mitochondrial benzodiazepine receptors in the ventral tegmental area modulate sexual behaviour of cycling or hormone-primed hamsters. J of Neuroendocrinology, 15(7), 677-686. 86. Frye, C.A. & Petralia, S.M. (2003). Lordosis of rats is modified by neurosteroidogenic effects of membrane benzodiazepine receptors in the ventral tegmenal area. Neuroendocrinology, 77(1),71-82. 85. Herzog, A.G. & Frye, C.A. (2003). Seizure exacerbation associated with inhibition of progesterone metabolism. Ann Neurol., 53(3), 390-391. 84. Frye, C.A. & Rhodes, M.E. (2003). Zaprinast, a phosphodiesterase 5 inhibitor, overcomes sexual dysfunction produced by fluoxetine, a selective serotonin reuptake inhibitor in hamsters. Neuropsychopharmacology 28, 310-316. 83. Frye, C.A. & Rhodes, M.E. (2002). Enhancing effects of estrogen on inhibitory avoidance performance may be in part independent of intracellular estrogen receptors in the hippocampus. Brain Research 956(2), 285-293. 82. Frye, C.A., Rhodes, M.E., Walf, A., and Harney, J.P. (2002). Testosterone enhances aggression in wild type mice but not mice deficient in Type I 5α-reductase. Brain Research 948(1-2), 165-170. 81. Frye, C.A. & Orecki, Z.A. (2002). Prenatal stress alters reproductive responses of rats in behavioral estrus and paced mating of hormone-primed rats. Hormones and Behavior 42(4), 472-483. 80. Frye, C.A., Rhodes, M.E., Rosellini, R. & Svare, B. (2002). The nucleus accumbens as a site of action for rewarding properties of testosterone and its 5α-reduced metabolites. Pharmacology, Biochemistry, & Behavior 74(1), 119-127. 79. Freeman, E.W., Frye, C.A., Rickels, K., Martin, P.A.G. and Smith S.S. (2002). Allopregnanolone levels and symptom improvement in severe premenstrual syndrome. J. Clinical Psychopharmacology 22(5), 516-20. 78. Seliga, A. & Frye, C.A. (2002). Olanzapine and progesterone dose-dependent and additive effects to enhance lordosis and progestin concentrations of rats. Physiology and Behavior 76, 151-158. 77. Schmitz, C., Rhodes, M.E., Bludau, M., Kaplan, S., Ong, S., Ueffing, I., Vehoff, J., Korr, H. & Frye, C.A. (2002). Depression: reduced number of granule cells in the hippocampus of female, but not male, rats due to prenatal restraint stress. Molecular Psychiatry 7(7), 810-813. 76. McCormick, C.M., Kehoe, P., Mallinson, K., Cecchi, L., & Frye, C.A. (2002). Neonatal isolation alters stress hormone and mesolimbic dopamine release in juvenile rats. Pharmacology, Biochemistry, and Behavior 73(1), 77-85. 75. Frye, C.A. & Orecki, Z. (2002). Prenatal stress producing deficits in socio-sexual behavior of cycling, but not hormone-primed, Long-Evans rats. Pharmacology, Biochemistry, and Behavior 73(1), 53-60. 74. Frye, C.A., Rhodes, M.E., Walf, A.A., and Harney, J. (2002). Progesterone reduces pentylenetetrazol- induced ictal activity of wild type mice but not those deficient in Type I 5α-reductase. Epilepsia 43, 14-17. 73. Frye, C.A. & Walf, A.A. (2002). Changes in progesterone metabolites in the hippocampus can modulate open field and forced swim test behavior of proestrous rats. Hormones and Behavior 41(3), 306-315. 72. Anderson, D. A., Shapiro, J. R., Lundgren, J. D., Spataro, L. E., & Frye, C. A. (2002). Self-reported dietary restraint is associated with elevated levels of salivary cortisol. Appetite 38(1), 13-17. 71. Frisone, D.F., Frye, C.A. & Zimmerberg B. (2002). Social isolation stress during the third week of life has age-dependent effects on spatial learning in rats. Behavioral Brain Research 128 (2), 153-160. 70. Frye, C.A. & Seliga, A.M. (2001). Testosterone increases analgesia, anxiolysis, and cognitive performance 12
  13. 13. of male rats. Cognitive and Affective Behavioral Neuroscience 1 (4), 371-381 69. Rosellini, R.A., Rhodes, M.E., Svare, B.B. & Frye, C.A. (2001). The testosterone metabolite and neurosteroid 3α-Androstanediol may mediate the effects of testosterone on conditioned place preference. Brain Research Reviews, 37, 162-171. 68. Frye, C.A. (2001). The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodents. Brain Research Reviews, 37, 201-222. 67. Frye, C.A. & Vongher, J.M. (2001). Ventral tegmental area infusions of inhibitors of the biosynthesis and metabolism of 3α,5α-THP attenuate lordosis of hormone-primed and behavioral oestrous rats and hamsters. J Neuroendocrinology, 13, 1076-1086. 66. Frye, C.A., Rhodes, M.E., Walf, A.A., and Harney, J.P. (2001). Testosterone reduces pentylenetetrazole- induced ictal activity in wild type mice but not those deficient in Type I 5α-reductase. Brain Research, 918, 182-186. 65. Rhodes, M.E. & Frye, C.A. (2001). Inhibiting progesterone metabolism in the hippocampus of rats in behavioral estrous decreases anxiolytic, and enhances exploratory and anti-nociceptive behaviors. Cognitive and Affective Behavioral Neuroscience, 1(3), 287-296. 64. Frye, C.A. & Vongher, J.M. (2001). Progesterone and 3α,5α-THP enhance sexual receptivity in mice. Behavioral Neuroscience, 115, 1118-1128. 63. Altemus,M., Redwine, L.S., Leong, Y.M., Frye, C.A., Porges, S.W., & Carter, C.S. (2001). Responses to laboratory psychosocial stress in post-partum women. Psychosomatic Medicine, 63, 814-821. 62. Frye, C.A. & Muscatiello, N.A. (2001). 3α,5α-THP in the raphe magnus attenuates PTZ-induced myoclonic seizures. Brain Research, 911, 146-151. 61. Frye, C.A. (2001). The role of neurosteroids and nongenomic effects of progestins in the ventral tegmental area in mediating sexual receptivity of rodents. Hormones and Behavior, 40, 226-233. 60. Frye, C.A., Park, D., Tanaka, M., Rosellini, R., & Svare, B. (2001). The testosterone metabolite and neurosteroid 3α-androstanediol may mediate the effects of testosterone on conditioned place preference. Psychoneuroendocrinology, 26, 731-750. 59. Frye, C.A. & Lacey, E.H. (2001). Posttraining androgens’ enhancement of cognitive performance is temporally distinct from androgen’ increases in affective behavior. Cognitive and Affective Behavioral Neuroscience, 1(2), 172-182. 58. Frye, C.A. (2001). Inhibition of 5α-reductase enzyme or GABA(A) receptors in the VMH and the VTA attenuates progesterone-induced sexual behavior in rats and hamsters. Journal of Endocrinological Investigation, 24, 399-407. 57. Frye, C.A. (2001). Estradiol tends to improve inhibitory avoidance performance in adrenalectomized male rats and reduces pyknotic cells in the dentate gyrus of adrenalectomized male and female rats. Brain Research, 889, 358-363. 56. Kehoe, P., Mallinson, K., McCormick, C.M. & Frye, C.A. (2000). Central allopregnanolone is increased in rat pups in response to repeated, short episodes of neonatal isolation. Developmental Brain Research, 124, 133-136. 55. Frye, C.A. & Lacey, E.H. (2000). Progestins influence performance on cognitive tasks independent of changes in affective behavior. Psychobiology, 28, 550-563. 54. Frye, C.A., Manjarrez, J., & Camacho-Arroyo, I. (2000). Infusion of 3α,5α-THP to the pontine reticular formation attenuates PTZ-induced seizures. Brain Research, 881, 98-102.
  14. 14. 53. Frye, C.A., Petralia, S.M., & Rhodes, M.E. (2000). Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3α,5α-THP. Pharmacology, Biochemistry, and Behavior, 67, 587-596. 52. Frye, C.A., Murphy, R.E., & Platek, S.M. (2000). Anti-sense oligonucleotides, for progestin receptors in the VMH and glutamic acid decarboxylase in the VTA, attenuate progesterone-induced lordosis in hamsters and rats. Behavioral Brain Research, 115, 55-64. 51. Bitran, D., Foley, M., Audette, D., Leslie, N. & Frye, C.A. (2000). Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat. Psychopharmacology, 151, 64-71. 50. Frye, C.A. & McCormick, C.M. (2000). Androgens are neuroprotective in the dentate gyrus of adrenalectomized female rats. Stress, 3, 185-194. 49. Frye, C.A., Bayon, L.E. & Vongher, J.M. (2000). Intravenous progesterone elicits a more rapid induction of lordosis in rats than does SKF38393. Psychobiology, 28, 99-109. 48. Frye, C.A. & Scalise, T.J. (2000). Anti-seizure effects of progesterone and 3α,5α -THP in kainic acid and perforant pathway models of epilepsy. Psychoneuroendocrinology, 25, 407-420. 47. Frye, C.A. & McCormick, C.M. (2000). The neurosteroid, 3α-Androstanediol, prevents inhibitory avoidance deficits and pyknotic cells in the granule layer of the dentate gyrus induced by adrenalectomy in rats. Brain Research, 855, 166-170. 46. Kelsey, J.E., Sanderson, K.L., Frye, C.A. (2000). Perforant path stimulation in rats produces seizures, loss of hippocampal neurons, and a deficit in spatial mapping which is reduced by prior MK-801. Behavioral Brain Research, 107, 59-69. 45. Vongher, J.M. & Frye, C.A. (1999). Progesterone in conjunction with estradiol has neuroprotective effects in an animal model of neurodegeneration. Pharmacology, Biochemistry and Behavior, 64, 777-785. 44. Frye, C.A. & Bayon, L.E. (1999). Mating stimuli influence endogenous variations in the neurosteroids 3α,5α-THP and 3α-Diol. Journal of Neuroendocrinology, 11, 839-847. 43. Frye, C.A. & Vongher, J.M. (1999). Progestins’ rapid facilitation of lordosis when applied to the ventral tegmentum corresponds to efficacy at enhancing GABAA receptor activity. Journal of Neuroendocrinology, 11, 829-837. 42. Frye, C.A. & Vongher, J.M. (1999). GABAA, D1, and D5, but not progestin receptor, antagonist and anti- sense oligonucleotide infusions to the ventral tegmental area of cycling rats and hamsters attenuate lordosis. Behavioral Brain Research, 103, 23-34. 41. Frye, C.A. & Vongher, J.M. (1999). 3α,5α-THP in the midbrain ventral tegmental area of rats and hamsters is increased in exogenous hormonal states associated with estrous cyclicity and sexual receptivity. Journal of Endocrinological Investigation, 22, 455-464. 40. Kellogg, C.K. & Frye, C.A. (1999). Endogenous levels of 5α-reduced progestins and androgens in fetal vs. adult rat brains. Developmental Brain Research, 115, 17-24. 39. Frye, C.A. & Lacey, E.H. (1999). The neurosteroids DHEA and DHEAS may influence cognitive performance by altering affective state. Physiology & Behavior, 66, 85-92. 38. Wilson, M.A. & Frye, C.A. (1999). Effects of chronic benzodiazepine exposure on stress-induced neuroactive steroid levels. Brain Research, 824, 136-139. 37. Frye, C.A. & Bayon, L.E. (1999). Prenatal stress reduces the effectiveness of the neurosteroid 3α,5α-THP to block kainic-acid-induced seizures. Developmental Psychobiology, 34, 227-234. 14
  15. 15. 36. Morgan, K.N., Thayer, J.E. & Frye, C.A. (1999). Prenatal stress suppresses rat pup ultrasonic vocalization and myocolonic twitching in response to separation. Developmental Psychobiology, 34, 205-215. 35. Frye, C.A. & Vongher, J.M. (1999). Progesterone has rapid and membrane effects in the facilitation of female mouse sexual behavior. Brain Research, 815, 259-269. 34. Frye, C.A. & Bayon, L.E. (1999). Cyclic withdrawal from endogenous and exogenous progesterone increases kainic acid and perforant pathway induced seizures. Pharmacology, Biochemistry and Behavior, 62, 315-321. 33. Frye, C.A., Bayon, L.E., Pursnani, N. & Purdy, R.H. (1998). The neurosteroids, progesterone and 3α,5α- THP, enhance sexual motivation, receptivity, and proceptivity in female rats. Brain Research, 808, 72-83. 32. Dunn, R.W., Reed, T.A.W., Copeland, P.D. & Frye, C.A. (1998). The nitric oxide synthase inhibitor 7- nitroindazole displays enhanced anxiolytic efficacy without tolerance in rats following subchronic administration. Neuropharmacology, 37, 899-904. 31. Frye, C.A. & Bayon, L.E. (1998). Seizure activity is increased in endocrine states characterized by decline in endogenous levels of the neurosteroid 3α,5α-THP. Neuroendocrinology, 68, 272-280. 30. Smith, S.S., Gong, Q.H., Li, X., Moran, M.H., Bitran, D., Frye, C.A. & Hsu, F.C. (1998). Withdrawal from 3α-OH-5α-pregnan-20-one using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated current and increases the GABAA receptor α4 subunit in association with increased anxiety. Journal of Neuroscience, 18, 5275-5284. 29. Frye, C.A. & Reed, T.A. (1998). Androgenic neurosteroids: anti-seizure effects in an animal model of epilepsy. Psychoneuroendocrinology, 23, 385-399. 28. Frye, C.A., Scalise, T.J. & Bayon, L.E. (1998). Finasteride blocks the reduction in ictal activity produced by exogenous estrous cyclicity. Journal of Neuroendocrinology, 10, 291-296. 27. Bitran, D., Hilvers, R.J., Frye, C.A. & Erskine, M.S. (1996). Chronic anabolic-androgenic steroid treatment affects brain GABAA receptor-gated chloride ion transport. Life Sciences, 58, 573-583. 26. Frye, C.A., Van Keuran, K.R., Rao, P.N. & Erskine, M.S. (1996). Progesterone and 3α-Androstanediol conjugated to bovine serum albumin affects estrous behavior when applied to the MBH and POA. Behavioral Neuroscience, 110, 603-612. 25. Frye, C.A., Van Keuran, K.R., Rao, P.N. & Erskine, M.S. (1996). Analgesic effects of the neurosteroid 3α- Androstanediol. Brain Research, 709, 1-9. 24. Frye, C.A., McCormick, C.M., Coopersmith, C. & Erskine, M.S. (1996). Effects of paced and non-paced mating stimulation on plasma progesterone, 3α-Diol and corticosterone. Psychoneuroendocrinology, 21, 431-439. 23. Frye, C.A., Duncan, J.E., Basham, M. & Erskine, M.E. (1996). Behavioral effects of 3α-Androstanediol II: Hypothalamic and preoptic area actions via GABAergic mechanism. Behavioral Brain Research, 79, 119-130. 22. Frye, C.A., Van Keuran, K.R. & Erskine, M.S. (1996). Behavioral effects of 3α-Androstanediol I: modulation of sexual receptivity and promotion of GABA-stimulated chloride flux. Behavioral Brain Research, 79, 109-118.] 21. Frye, C.A. & Gardiner, S.G. (1996). Progestins can have a membrane-mediated action in rat midbrain for facilitation of sexual receptivity. Hormones and Behavior, 30, 682-691. 20. Frye, C.A. & Duncan, J.D. (1996). Estradiol benzoate potentiates neuroactive steroids' effects on pain sensitivity. Pharmacology, Biochemistry and Behavior, 53, 27-32. 19. Frye, C.A. (1995). The neurosteroid 3α,5α-THP has antiseizure and possible neuroprotective effects in an
  16. 16. animal model of epilepsy. Brain Research, 696, 113-120. 18. Crystal, S., Frye, C.A. & Kanarek, R.B. (1995). Taste preferences and sensory perceptions in female varsity swimmers. Appetite, 24, 25-36.] 17. Frye, C.A. & Sturgis, J.D. (1995). Neurosteroids affect spatial/reference, working, and long-term memory of female rats. Neurobiology of Learning and Memory, 64, 83-96. 16. Frye, C.A. (1995). Estrus-associated decrements in a water maze task are limited to acquisition. Physiology & Behavior, 57, 5-14. 15. DeBold, J.F. & Frye, C.A. (1994). Genomic and non-genomic actions of progesterone in the control of female hamster sexual behavior. Hormones and Behavior, 28, 445-453. 14. DeBold, J.F. & Frye, C.A. (1994). Progesterone and the neural mechanisms of hamster sexual behavior. Psychoneuroendocrinology, 19, 563-579. 13. Frye, C.A., Crystal, S., Ward, K.D. & Kanarek, R.B. (1994). Menstrual cycle and dietary restraint influence taste preferences in young women. Physiology & Behavior, 55, 561-567. 12. Frye, C.A. & Weisberg, R.B. (1994). Increasing the incidence of routine pelvic examinations: Behavioral Medicine's contribution. Women and Health, 21, 33-55. 11. Frye, C.A. & Leadbetter, E.A. (1994). 5α-reduced progesterone metabolites are essential in hamster VTA for sexual receptivity. Life Sciences, 54, 653-659. 10. Frye, C.A. & Duncan, J.E. (1994). Progesterone metabolites, effective at the GABAA receptor complex, attenuate pain sensitivity in rats. Brain Research, 643, 194-203. 9. Frye, C.A. & DeMolar, G. (1994). Menstrual cycle and sex differences influence salt preference. Physiology & Behavior, 55, 193-197. 8. Frye, C.A., Mermelstein, P.G. & DeBold, J.F. (1993). Bicuculline infused into the hamster ventral tegmentum inhibits, while sodium valproate facilitates, sexual receptivity. Pharmacology, Biochemistry and Behavior, 46, 1-8. 7. Frye, C.A., Cuevas, C.A. & Kanarek, R.B. (1993). Diet and estrous cycle influence pain sensitivity in rats. Pharmacology, Biochemistry and Behavior, 45, 255-260. 6. Frye, C.A. & DeBold, J.F. (1993). 3α-OH-DHP and 5α-THDOC implants to the ventral tegmental area facilitate sexual receptivity in hamsters after progesterone priming to the ventral medial hypothalamus. Brain Research, 612, 130-137. 5. Frye, C.A. & DeBold, J.F. (1993). P-3-BSA, but not P-11-BSA, implants in the VTA rapidly facilitate receptivity in hamsters after progesterone priming to the VMH. Behavioral Brain Research, 53, 167-175. 4. Frye, C.A., Mermelstein, P.G., & DeBold, J.F. (1992). Evidence for a non-genomic action of progestins on sexual receptivity in hamster ventral tegmental area but not hypothalamus. Brain Research, 578, 87-93. [ 3. Frye, C.A., Bock, B.C. & Kanarek, R.B. (1992). Hormonal milieu affects tailflick latency in female rats and may be attenuated by access to sucrose. Physiology & Behavior, 52, 699-706. 2. Frye, C.A. & DeBold, J.F. (1992). Muscimol facilitates sexual receptivity in hamsters when infused into the ventral tegmentum. Pharmacology, Biochemistry & Behavior, 42, 879-887. 1. Frye, C.A. & Erskine, M.S. (1990). Influence of time of mating and paced copulation on induction of pseudopregnancy in cyclic female rats. Journals of Reproduction and Fertility, 90, 375-385. 16
  17. 17. PEER-REVIEWED BOOK CHAPTERS & REVIEWS 1. Frye, C.A. (2008). Neurosteroids-From Basic Research to Clinical Perspectives. Editors: Robert T. Rubin and Donald W. Pfaff 2. Frye, C.A. (2008). Hormonal influences on seizures: Basic neurobiology. Epilepsy in women-scientific management. Editor: Cynthia Harding 3. Frye, C.A. & Rhodes, M.E. (2008). Female sex steroids and neuronal excitability. In: Encyclopedia of Basic Epilepsy Research. Editor: Phil Schwartzkroin. 4. Frye, C.A. & Rhodes, M.E. (2008). Male sex steroids and neuronal excitability. In: Encyclopedia of Basic Epilepsy Research. Editor: Phil Schwartzkroin. 5. Goyette, S.R., Edinger, K.L., Luine, V., Young, J. & Frye, C.A. (2008). Northeast Under/graduate Research Organization for Neuroscience (NEURON): Our third New York City meeting. The Journal for Undergraduate Neuroscience Education, in press 6. Rhodes, M.R., Edinger, K.L., Smith, J., Luine, V., & Frye, C.A. (2008). Northeast Under/graduate Research Organization for Neuroscience (NEURON): An update on our tenth annual conference for neuroscience trainees and educators. Journal of Behavioral and Neuroscience Research ,in press. 7. Frye, C.A. & Rhodes, M.E. (2007). The role of midbrain 3α,5α-THP in mediating exploration, anxiety, social and reproductive behavior In: Neuroactive Steroids in Brain: From Experiments to Psychopathology and Treatment. Editors: Michael S. Ritsner and Abraham Weizman 8. Frye, C.A. & Rhodes, M.E. (2007). The role and mechanisms of steroid hormones to enhance approach behavior. In: Handbook of approach and avoidance motivation. A. Elliot (Ed.), Mahwah, NJ: LEA. 9. Frye, C.A. & Rhodes, M.E. (2007). Reciprocal effects of exploration, anxiety, social, and sexual behaviors and progestins in midbrain, hippocampus, diencephalon, and cortex In: Evolutionary Molecular Strategies and Plasticity: Editors: Marcello Canonaco and Rosa Maria Facciolo 10. Harden, C.L. & Frye, C.A. (2008). Chapter194, Hormone Changes in Epilepsy in Epilepsy: A Comprehensive Textbook, Second Edition 11. Edinger, K.L., Smith, J., Luine, V., & Frye, C.A. (2005). Northeast Under/graduate Research Organization for Neuroscience (NEURON): An update on our ninth annual conference for neuroscience trainees and educators. Journal of Behavioral and Neuroscience Research, 2, 1-7. 12. Frye, C.A. & Edinger, K.L. (2004). Northeast Under/graduate Research Organization for Neuroscience (NEURON): A regional neuroscience meeting for undergraduates, graduate students, and faculty. The Journal for Undergraduate Neuroscience Education, 2, 36-40. 13. Edinger, K.L., Morgan, K., Blasberg, M., & Frye, C.A. (2004). Northeast Under/graduate Research Organization for Neuroscience (NEURON): An update on our eighth annual conference for neuroscience trainees and educators. Journal of Behavioral and Neuroscience Research, 1, 1-8. 14. Frye, C. A. & Petralia, S. M. (2003). 3α,5α-THP’s actions in the ventral tegmental area for lordosis: A model system for defining function and mechanisms of progestins. In: S. Smith (Ed). Neurosteroids and the GABAA Receptor. CRC Press, Boca Raton, FL. 15. Frye, C.A. & Petralia, S.M. (2003). Progestins have actions through GABAA receptors, In: C.S. Watson (Ed.), The Identities of Membrane Steroid Receptors: And Other Proteins Mediating Nongenomic Steroid Action, Kluwer Academic Publishers, Boston, MA. 16. Rhodes, M.E., Frye, C.A. (2002). Hormones influence cognitive performance, In: R. Flint (Ed.), Forget it? -Sources, Theories, and Mechanisms of Alterations in Mnemonic Function, Erudition Books, North Chelmsford, MA, 175-196. 17. Frye, C.A., Weisberg, R.B. & Hinkson, A.B. (2000). Anxiety and women's health. The management of stress and anxiety in medical disorders (Eds. D.I. Mostofsky & D.H. Barlow) Allyn & Bacon, Needham, MA. 18. Frye, C.A. (2000). Integration of affiliation: Well done! Trends in Endocrinology and Metabolism, 11, 155-157. 19. Frye, C.A. (2000). Neurosteroids: A new regulatory function in the Nervous System. The Quarterly
  18. 18. Review of Biology, 75, 349-350. 20. Smith, S.S., Hsu, F.C., Li, X., Frye, C.A., Faber, D.S., & Markowitz, R.S. (2000). Oestrogen effects in olivo-cerebellar and hippocampal circuits. Neural and cognitive effects of oestrogens. Wiley, Chichester, 230, 155-172. 21. Frye, C.A. (1996). Investigation of stimuli eliciting displays in labyrinth fish: A simple behavioral assay useful in teaching neuroscience. Neuroscience Methods: The Undergraduate Laboratory Experience, Trinity College Press, Hartford, CT. INVITED TALKS Frye, C.A. (2008). Enhancing children’s neural and cognitive development through reading. Delaware Community School, Albany, NY. Frye, C.A. (2008). The role of actions at ERbeta in beneficial effects of estrogens and progestins. Organization for the study of sex differences conference, New Orleans, LA. Frye, C.A. (2008). The role of neurosteroids and actions at ERbeta for physical and psychology effects of hormone therapies. Wyeth Pharmaceuticals, Collegeville, PA. Frye, C.A. (2008). Progestogens...of, for, and by the nervous system are not just for pregnancy. Drexel University Medical School, Pharmacology Department, Philadelphia, PA. Frye, C.A. (2008). Steroid hormones in mental health and disease. International Congress of Neuropsychiatry, Cancun Mexico Frye, C.A., Walf, A.A. (2008). Estrogen receptor beta as a target for the anti-anxiety and anti-depressant effects of steroids Conference of The Society for The Study of Sex Diffferences, New Orleans, LA. Frye, C.A., (2008). Functional effects of neurosteroids-hormones that are of the nervous system, by the nervous system, and for the nervous system. Albert Einstein School of Medicine, Bronx, NY Frye, C.A., (2007). Estrogen receptor beta as a target for steroids’ effects on affective and cognitive behavior. Annual Graylyn Conference on Women's Cognitive Health, Wake Forest, NC. Frye, C.A., (2007). Progestins actions in the midbrain to enhance lordosis involve GABA, dopamine and glutamate receptors and their downstream signal transduction factors. Conference on Rapid Response Signaling of Steroid Hormones, Dublin, Ireland. Frye, C.A., (2007). Neurosteroids- Of the nervous system, by the nervous system, for the nervous system. Skidmore College, Saratoga Springs, NY. Frye, C.A., Walf, A.A. (2007). Actions at estrogen receptor β may underlie some of the anti-anxiety, anti- depressant, and memory enhancing effects of steroids. Conference on Steroids and the Nervous System. Torino, Italy. Frye, C.A.(2007). The global impact of behavioral endocrinology-hormones across the world.. Conference on Steroids and the Nervous System. Torino, Italy. Paris, J.J., Rhodes, M.E., Frye, C.A. (2007). Inhibition of 3α,5α-THP formation decreases exploratory/anti- anxiety and socio-sexual behavior in sexually receptive female rats. Conference on Steroids and the Nervous System. Torino, Italy. Frye, C.A., Paris, J.J. (2006). 3α-androstanediol may underlie some of testosterone’s positive hedonic and/or drug-related effects. International Society for Biomedical Research on Alcoholism -World Congress on Alcohol Research, Sydney, Australia. Frye, C.A., Walf, A.A. (2006). Anti-anxiety and anti-depressant effects of steroids with actions at estrogen receptor β. 37th Annual International Society for Psychoneuroendocrinology (ISPNE) meeting. Leiden, Netherlands. 18
  19. 19. Frye, C. A. (2006). Effects of pre-natal manipulations on response to stress during development and in adulthood. Pharmacology, Biochemistry and Behavior 7th Meeting: Adolescence-Alcohol, Drugs, and Mental Disorders, Morzine, France. Frye, C.A. (2006). Rewarding effects of progestins: Importance for drug abuse. Pharmacology, Biochemistry and Behavior 7th Meeting: Adolescence-Alcohol, Drugs, and Mental Disorders, Morzine, France. Rhodes, M.E., Frye, C.A. (2006). Rewarding effects of androgen: Importance for drug abuse. Pharmacology, Biochemistry and Behavior 7th Meeting: Adolescence-Alcohol, Drugs, and Mental Disorders, Morzine, France. Walf, A.A., Frye, C.A. (2006). Antidepressant-like effects of estrogen receptor modulators after short-term treatment. Pharmacology, Biochemistry, and Behavior Conference, 7th Meeting, Morzine, France. Walf, A.A., Rhodes M.E., Frye, C.A. (2006). Rewarding effects of estrogen: Importance for drug abuse. Pharmacology, Biochemistry, and Behavior Conference, 7th Meeting, Morzine, France. Frye, C.A. (2005). Ovarian hormones in animal models of catamenial epilepsy. Special Interest Group – Animal Models of Catamenial Epilepsy at the American Epilepsy Society Meeting, Washington, DC. Frye, C.A. (2005). Differential behavioral effects of estradiol through ERα and ERβ. National Academy of Sciences of the Czech Republic, Prague, Czech Republic. Frye, C.A. (2005). Role of progesterone in animal models of schizophrenia. Prague Center for Psychiatry, Prague, Czech Republic. Petralia, S. M., Sumida, K., & Walf, A. A., Frye, C. A. (2005). Progestin-facilitated sexual behavior of female rats may involve activity of adenylyl cyclase in the ventral tegmental area (VTA). International Conference on Steroids and the Nervous System, Torino, Italy. Rhodes, M. E., Petralia, S.M., Jahagirdar, V., & Frye, C. A. (2005). Actions of the neurosteroids, 3α, 5α-THP, in the ventral tegmental area, mediate socio-sexual behaviors. International Conference on Steroids and the Nervous System, Torino, Italy. Frye, C.A. & Rhodes, M.E. (2004). Ovarian hormones and their effects on cortical excitation and influences on epileptogenesis. Women and Epilepsy Advisory Board, Atlanta, GA. Frye, C.A. (2004). Sex differences in rats: anxiety responses to androgens, Pharmacology, Biochemistry and Behavior Conference, Morzine, France. Frye, C.A. & Rhodes, M.E. (2003). Androgens and seizures. American Epilepsy Society Conference, Boston, MA. Frye, C.A. (2003). Novel actions of steroid hormones- basic and clinical research. Marywood University, Scranton, PA. Frye, C.A. (2003). Membrane actions of hormones and the relationship to function. Marywood University, Scranton, PA. Frye, C.A. (2003). Approaches to enhance training of neuroscience. International Brain Research Organization, Prague, CZ. Frye, C.A. (2003). Sex and hormonal differences in response to gestational stress. TENNET Conference, Montreal, CANADA. Frye, C.A. (2003). The functional role of neurosteroids. CUNY-Park Avenue Colloquium, New York City, NY. Frye, C.A., Petralia, S., & Rhodes, M.E. (2003). Fluoxetine’s effects on sexual function may involve allopregnanolone in the ventral tegmental area. International Conference on Steroids and the Nervous System, Torino, Italy. Frye, C.A. (2003). Non-ER mediated effects of estrogen on learning and memory. Experimental Biology Meeting,
  20. 20. San Diego, CA. Frye, C.A. & Rhodes, M.E. (2003). Estrogen may have genomic and non-genomic actions in the dorsal hippocampus to improve inhibitory avoidance performance. Twenty-seventh Annual Winter Conference on the Neurobiology of Learning & Memory at Park City, Park City, UT. Frye, C.A. (2002). The role of non-genomic actions of steroids in mediating reproductive, affective and cognitive behaviors. CUNY-Brooklyn, Psychology Department Colloquia. Frye, C.A. (2002). Mating-induced neurosteroidogenesis in the hippocampus induces anxiolysis of female rats. Workshop on Steroid Hormones and Brain Function, Breckenridge, Co. Frye, C.A. & Epperson, N. (2002). Neurosteroid modulation of γ-Aminobutyric Acid neuronal function: Clinical implications. Workshop on Steroid Hormones and Brain Function, Breckenridge, Co. Herzog, A.G., Frye, C.A., Drislane, F.W., Friedman, M.N., & Schomer, D.L. (2001). Neuroactive reproductive steroid changes in men with epilepsy: associations with sexual function and potential implications for neuronal excitability. American Epilepsy Society Conference, Philadelphia, PA. Frye, C.A. (2001). Non-genomic actions of steroid hormones mediate social, affective, and cognitive behavior American College of Neuropsychopharmacology. Waikoloa, Hawaii. Frye, C.A. (2001). Developing Programs in Neuroscience at the Small College and University, NSF Sponsored Project Kaleidoscope Workshop on “Neuroscience Education: From the Enchanted Loom to the World Wide Web”, Hartford, Connecticut. Frye, C.A. (2001). North East Undergraduate Research Organization for Neuroscience (N.E.U.R.O.N.), A regional program to promote training in Neuroscience Undergraduate. NSF Sponsored Project Kaleidoscope Workshop on “Neuroscience Education: From the Enchanted Loom to the World Wide Web”, Hartford, Connecticut. Frye, C.A. (2001). Distinguishing allopregnanolone’s effects on anxiety from other behaviors. American Neuroendocrine Society Conference, Breckenridge, Co. Frye, C.A. (2001). Neurosteroids and anxiety. Symposium Organizer and Chair, American Neuroendocrine Society Conference, Breckenridge, Co. Frye, C.A. (2001). Neurosteroids actions in modulating reproductive and non-reproductive behavior. Neuroscience Symposium Series, Brigham Young University, Provo, Utah. Frye, C.A. & Muscatiello, N. (2001). The mechanism of action of progestins’ anti-seizure effects in the hindbrain. Workshop on the Neurobiology of Epilepsy, Iguazu, Brazil. Frye, C.A. (2001). 3α,5α-THP in the raphe nucleus and pontine reticular formation attenuate myoclonic and tonic clonic seizures. Spring Epilepsy Research Conference, Grand Cayman, BWI. Frye, C.A. (2001). Assessing factors which influence anti-seizure effects of neurosteroids: Integration of basic and clinical research. Workshop on Steroid Hormones and Brain Function, Breckenridge, Co. Frye, C.A. (2001). The role of NMDA receptors in the VTA in mediating progestin-facilitated sexual receptivity. Workshop on Steroid Hormones and Brain Function, Breckenridge, Co. Frye, C.A. (2001). How do steroids mitigate sex, anxiety, learning and memory, and brain damage? LaDonne Heaton Schulman Endowed Lecture, Wheaton College, Norton, MA. Frye, C.A. (2001). The role of androstane neurosteroids in mediating reproductive and non-reproductive behavior. Neuroendocrinology Colloquium Series, The University of Milan, Italy. Frye, C.A. (2001). Factors which influence sexual differentiation by environmental endocrine disruptors-using 20
  21. 21. reproductive and non-reproductive behavior as indicators. The Department of Animal Sciences, The University of Florence, Italy. Frye, C.A. (2001). Neurosteroids in the Ventral Tegmental Area mediate sexual receptivity in rodents. International Conference on Steroids and the Nervous System, Torino, Italy. Frye, C.A. (2000). Two interactive exercises which engage students to learn about the brain. Eastern Section Siena State Teachers’ Conference, Albany, NY. Frye, C.A. (2000). What can progesterone’s actions for sex behavior in rodents tell us about neural substrates for learning and memory, anxiety and neuroprotection in people? The College of Saint Rose, Albany, NY. Frye, C.A. (2000). Neurosteroids mediate the onset and duration of sexual receptivity in rodents. Society for Behavioral Neuroendocrinology, Madrid, Spain. Frye, C.A. (2000). Neurosteroids …Of the Nervous system, by the Nervous System and for the Nervous System. Society for Behavioral Neuroendocrinology, Madrid, Spain Frye, C.A. , Rhodes, M.E., Spataro, L.E. (2000). The role of neurosteroids in the Ventral Tegmental Area in mediating sexual receptivity in rodents. Society for Behavioral Neuroendocrinology, Madrid, Spain. Frye, C.A., Petralia, S., & Rhodes, M.R. (2000). Sex and estrous cycle differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3α,5α-THP. Biological Basis of Sexual Orientation, Sex Identity, and Gender-Typical Behavior. Minot, North Dakota. Frye, C.A. (1999). Non-genomic actions of progestins on cognitive and affective behavior in rodents. The keynote address for National Congress of the Mexican Society of Physiological Sciences, Zacatecas, Mexico. Frye, C.A. (1999). Non-genomic actions of progesterone in the VTA-effects on sexual receptivity. National Congress of the Mexican Society of Physiological Sciences, Zacatecas, Mexico. Frye, C.A. & J.M. Vongher. (1999). The role of 3α,5α-THP in progesterone’s facilitation of sexual receptivity in mice. International Behavioral Neuroscience Conference, Nancy, France. Frye, C.A. (1999). Neurosteroids role in progestins' anti-seizure effects. Spring Epilepsy Research Conference, Grand Cayman, BWI. Frye, C.A. (1999). Neurosteroids & behavior. European Winter Conference on Brain Research, Aime, France. Frye, C.A. (1999). The role of neurosteroids in social behavior. European Winter Conference on Brain Research, Aime, France. Frye, C.A. (1999). Non-genomic actions of steroid hormones...functional consequences. Hudson-Berkshire Neuroscience Group, Albany, New York. Frye, C.A. (1998). Progestins mediate reproductive and non-reproductive behavior. The University at Albany- SUNY, Albany, NY. Frye, C.A. (1998). Neurosteroids mediate sexual, cognitive, and affective behavior. Emory University, Atlanta, GA. Frye, C.A. (1998). The role of steroid hormones in neurodegenerative disorders. Centenary College/Louisiana State University, Shreveport, LA. Frye, C.A. (1998). Progesterone’s mechanism of action. Georgia State University, Atlanta, GA. Frye, C.A. (1998). Neurosteroids and motivated behavior. Florida State University, Gainesville, FL. Frye, C.A. (1997). Progestins role in epilepsy. Epilepsy Foundation of America Regional Meeting. Darien, CT. Frye, C.A. (1997). Non-genomic effects of progesterone - Implications for PMS, Epilepsy and Alzheimer’s Disease. Rutgers University, Camden, NJ.
  22. 22. Frye, C.A. (1996). Neurosteroids role in reproductive and non-reproductive behavior. University of Southern Florida, Tampa, FL. Frye, C.A. (1996). Alzheimer’s disease: a focus on effects of hormones. Alleghany College, Alleghany, PA. Frye, C.A. (1996). Progestin mechanism of action; effects on reproductive and non-reproductive behavior. LeHigh University, Bethlehem, PA. Frye, C.A. (1995). Hormonally mediated taste preference - caveats and qualifications. Eastern Psychological Association, Boston, MA. Frye, C.A. (1995). The functional role of neurosteroids: Animal and human studies. Symposium chair and speaker, Winter Brain Conference, Steamboat Springs, CO. Frye, C.A. (1994). Androgens actions to inhibit sexual receptivity are non-genomic. Workshop on Steroid Hormones and Brain Function, Breckenridge, Co. Frye, C.A. (1994). Non-genomic steroid effects relevant for reproduction. Symposium chair and speaker, Conference on Reproductive Behavior, LeHigh Valley, PA. Frye, C.A. (1993). Mk-801 and nimodipine: Neuroprotective effects may not extend to behavior. Cambridge Neuroscience, Cambridge, MA. PUBLISHED ABSTRACTS Walf, A.A., Frye, C.A. (2005). Estradiol’s effects for anti-anxiety and anti-depressive behavior of female rodents may require activity at estrogen receptor β. Hormones and Behavior, 48 Rhodes, M.E., Raol, Y.H., Brooks-Kayal, A.R., Frye, C.A. (2005). Early post-natal handling altars pregnane neurosteroid levels. Hormones and Behavior, 48. Sumida, K., Walf, A.A., Frye, C.A. (2005). Protein Kinase A activity in the ventral tegmental area may be required for progest-facilitated lordosis of rats via GABAA and/or dopamine type-1 like receptors. Hormones and Behavior, 48. Rhodes, M.E. & Frye, C.A. (2005). Progestins' effects on hypothalamic-pituitary-adrenal axis for modulation of seizures. Epilepsia, 46, 225. Petralia, S. M., Sumida, K., & Walf, A. A., Frye, C. A. (2005). Progestin-facilitated sexual behavior of female rats may involve activity of adenylyl cyclase in the ventral tegmental area. Trabajos del Instituo Cajal. Petralia, S. M., & Frye, C. A. (2005) D 1 and D1-initiated intracellular signaling cascades in the ventral tegmental area mediate progesterone’s action for lordosis of hamsters. Trabajos del Instituo Cajal. Rhodes, M.E., Petralia, S. M., Jahagirdar, V., & Frye, C. A. (2005). Actions of the neurosteroid, 3α, 5α-THP, in the ventral tegmental area mediate socio-sexual behaviors. Trabajos del Instituo Cajal. Sumida, K., Rhodes, M. E., Dudek, B. C., Lydon, J. P., O’Malley, B. W., Pfaff, D. W. , Frye, C. A. (2005) Progesterone alters arousal behavior of aged PRKO mice. Trabajos del Instituo Cajal. Walf, A.A., Sumida, K., & Frye, C. A. (2005). Progestin-facilitated lordosis of female rats and hamsters involving dopamine type 1 and GABAA/Benzodiazepine receptors in the ventral tegmental area require activity of G-proteins. Trabajos del Instituo Cajal. Herzog, AG, Drislane, FW, Schomer, DL, Pennell, PB, Bromfield, EG, Dworetzky, BA, Farina, EL, Frye, CA. Differential effects of antiepileptic drugs on serum neuroactive steroid concentrations in men with localization related epilepsy. 2004. Epilepsia, 45, 7, pg. 122. Wawrzycki, J.M. & Frye, C.A. (2003). Effects of prenatal stress and gonadal hormone condition on depressive behavior of male and female rats. Hormones and Behavior, 44, 83. Walf, AA & Frye, C.A. (2003). Inhibiting intracellular estrogen receptors in the hippocampus, but not the amygdala, of proestrous rats attenuates anxiety and depressive behavior. Hormones and Behavior, 44, 82. Sumida, K., Rhodes, M.E, Rosellini, R.A., Svare, B. & Frye, C.A. (2003). Blockade of intracellular androgen receptors does not attenuate 3α-diol-induced conditioned place preference. Hormones and Behavior, 44, 79. Seliga, A.M., Frye, C.A., & Erskine, M.S. (2003). Infusions of FGIN-1-27, a neurosteroidogenic agent, into the 22
  23. 23. medial amygdala facilitates mating-induced pseudopregnancy of female rats. Hormones and Behavior, 44, 77. Rhodes, M.E. Sumida, K., & Frye, C.A. (2003). Estrogen can condition a place preference in female rats. Hormones and Behavior, 44, 72. Petralia, S.M., Jahagirdar, V.,& Frye, C.A. (2003). Ventral Tegmental Area infusions of the cAMP analogue 8- Bromo-cAMP increases lordosis of cylcing and hormone-primed rats and hamsters. Hormones and Behavior, 44, 70. Jahagirdar, V., Petralia, S.M.& Frye, C.A. (2003). Infusions of P450 side-chain cleavage or 5α-reductase enzyme inhibitors to the ventral tegmental area decrease lordosis of rats in behavioral estrous. Hormones and Behavior, 44, 56. Frye, C.A. & Petralia, S.M. (2003). Picrotoxin reduces the facilitative effects of neurosteroidogenesis in the Ventral Tegmental Area on sexual behavior of rats and hamsters. Hormones and Behavior, 44, 50. Edinger, K., Walf, A. A., Frye, C. A. (2003). Infusions of testosterone or its 5α-reduced metabolites to the dorsal hippocampus decrease anxiety, nociceptive, and fear behavior and enhance spatial learning. Hormones and Behavior, 44, 46. Petralia, S.M., & Frye, C. A. (2003). Progestins in the ventral tegmental area may mediate lordosis in part by actions at dopamine type 1 receptors, cAMP, and DARPP-32. Trabajos del Instituto Cajal, 79, 139. Edinger, K., Walf, A.A., and Frye, C.A. (2003). Androgen implants to the dorsal hippocampus can enhance anxiolysis, analgesia, and cognitive performance of male rats. Trabajos del Instituto Cajal, 79, 229-230. Walf A.A. and Frye, C.A.. (2003). Systemic and intra-amygdala administration of estrogen and progesterone to ovariectomized rats increases analgesia. Trabajos del Instituto Cajal, 79, 185-186. Frye, C.A., Petralia, S.M., Rhodes, M.E., Stein, B. (2003). Fluoxetine’s effects on sexual function may involve allopregnanolone in the ventral tegmental area. Trabajos del Instituto Cajal, 79, 46-47. Rosellini, R.A., Rhodes, M.E., Svare, B. & Frye, C.A. (2003). Testosterone’s hedonic effects may involve metabolism to 3α-diol and actions at GABAA receptors in the nucleus accumbens. Trabajos del Instituto Cajal, 79, 141-142. Rhodes, M.E. & Frye, C.A. (2003). Androgens’ anti-seizure effects may be due in part to actions at intracellular androgen receptors in the hippocampus. Trabajos del Instituto Cajal, 79, 181-182. Petralia, S. M., & Frye, C. A. (2002). Infusions to the ventral tegmental area of the GABAB agonist baclofen increase progesterone-facilitated sexual behavior of estrogen-primed rats and hamsters. Hormones and Behavior, 41, 484. Walf , A.A. and Frye, C.A. (2002). Changes in anxiety behavior of female rats may be due to progesterone- mediated mechanisms in the hippocampus. Hormones and Behavior, 41, 494-5. Rhodes, M.E., Doherty, L., & Frye, C.A. (2002). Estrogen’s improvement of inhibitory avoidance may be in part independent of intracellular estrogen receptors in the hippocampus. Hormones and Behavior, 41, 486. Petralia, S.M., & Frye, C. A. (2001). MK-801 infused into the ventral tegmental area of rats enhances progesterone-facilitated lordosis. Trabajos del Instituto Cajal, 68, 178-179. Herzog, AG, Frye, CA, Drislane, FW, Friedman, MN, Schomer, DL. Neuroactive reproductive steroid changes in men with epilepsy: associations with sexual function and potential implications for neuronal excitability. Epilepsia 42 Suppl. 7:297, 2001. Rosellini, R., Svare, B., Rhodes, M.E., & Frye, C.A. (2001). The testosterone metabolite and neurosteroid 3α- androstanediol mediates the effects of testosterone on conditioned place preference. Trabajos del Instituto Cajal, 68, 45-46. Frye, C.A., Walf, A.A., Rhodes, M.E. & Harney, J.P. (2001). Progesterone administration alters motor, social, affective, cognitive, and ictal behaviors in female 5α-reductase knockout mice. Trabajos del Instituto Cajal, 68, 142-143. Walf, A.A., Rhodes, M.E., Harney, J.P., & Frye, C.A. (2001). Testosterone administration alters motor, exploratory, nociception, aggression, cognitive performance, and ictal behaviors in male 5α-reductase mice. Trabajos del Instituto Cajal, 68, 148-149. Rhodes, M.E. & Frye, C.A. (2001). Inhibiting progesterone metabolism in the hippocampus alters aversion to noxious stimuli, exploratory, motor, and anxiolytic behaviors of proestrous rats. Trabajos del Instituto Cajal,
  24. 24. 68, 79-80. Frye, C.A. (2001). Neurosteroids in the Ventral Tegmental Area mediate sexual receptivity in rodents. Trabajos del Instituto Cajal, 68, 54-55. Muscatiello, N., McCormick, C.M. & Frye, C.A. (2001). Testosterone metabolism along estrogenic and androgenic pathways may both be important for neuroprotection in an adrenalectomy model of neurodegeneration. Trabajos del Instituto Cajal, 68, 163-164. Frye C.A., & Gardiner S.G. (1996). Progestins can have a membrane-mediated action in rat midbrain for facilitation of sexual receptivity that is likely GABA mediated. Ital J Anat Embryol ,101:, 162. 24
  25. 25. CONFERENCE PRESENTATIONS Cusher, D.S., Paris, J.J., Frye, C.A. (2008). Positive modulators of Pregnane Xenobiotic Receptor (PXR) facilitate lordosis when administered to the midbrain VTA of OVX/E2-Primed rats. Annual Psychology Department Honors Symposium at SUNY-Albany, Albany, NY. Friedman, J.A., Cusher, D.S., & Frye, C.A. (2008). Soy isoflavones alter cognitive, affective, and sexual behavior of rats without proliferative effects on reproductive tissues. Annual Psychology Department Honors Symposium at SUNY-Albany, Albany, NY. Llaneza, D.C., Paris, J.J., Frye, C.A. (2008). Sex differences in cognitive and affective behaviors of intact or castrated rats with progesterone implants. Annual Psychology Department Honors Symposium at SUNY- Albany, Albany, NY. Kim, S.H., Paris, J.J., Frye, C.A. (2008). Sex differences in effects of gestational stress on cognitive behavior and dendritic morphology of rats. Steroid Hormones and Brain Function, the 16th Annual Meeting, Key Largo, FL. Koonce, CJ., & Frye, C.A. Frye (2008). Progesterone facilitates lordosis in wildtype but not 5a-reductase knockout mice. Steroid Hormones and Brain Function, the 16th Annual Meeting, Key Largo, FL. Llaneza, D.C., Paris, J.J., Frye, C.A. (2008). Sex differences in cognitive and affective behaviors of intact or castrated rats with progesterone implants. Steroid Hormones and Brain Function, the 16th Annual Meeting, Key Largo, FL. Walf, A.A. & Frye, C.A. (2008). Estradiol enhances affective and sexual behavior and augments carcinogen- induced tumorigenesis in ovariectomized rats. Steroid Hormones and Brain Function, the 16th Annual Meeting, Key Largo, FL. Cusher, D.S., Paris, J.J., Frye, C.A. (2008). Positive modulators of Pregnane Xenobiotic Receptor (PXR) facilitate lordosis when administered to the midbrain VTA of OVX/E2-Primed rats. The University at Albany Undergraduate Research Conference, Albany, NY. Kim, S.H., Paris, J.J., Frye, C.A. (2008). Parental stress on cognitive behavior and dendritic morphology of female and male rats. The University at Albany Undergraduate Research Conference April 12-13, 2008, Albany, NY. Koonce, CJ., & Frye, C.A. Frye (2008). Progesterone facilitates lordosis in wildtype but not 5α-reductase knockout mice. Poster Presentation at The University at Albany Undergraduate Research Conference, Albany, NY. Llaneza, D.C., Paris, J.J., Frye, C.A. (2008). Sex differences in cognitive and affective behaviors of intact or castrated rats with progesterone implants. The University at Albany Undergraduate Research Conference, Albany, NY. Cusher, D.S., Paris, J.J., Frye, C.A. (2008). Positive modulators of Pregnane Xenobiotic Receptor (PXR) facilitate lordosis when administered to the midbrain VTA of OVX/E2-Primed rats. North-Eastern Undergraduate/ graduate Research Organization for Neuroscience, CUNY-Hunter, New York, NY. Kim, S.H., Paris, J.J., Frye, C.A. (2008). Gestational stress on exploratory behavior and dendritic morphology of male and female rats. Poster presentation at the annual meeting of the North-Eastern Undergraduate/graduate Research Organization for Neuroscience, CUNY-Hunter, New York, NY. Koonce, CJ., & Frye, C.A. (2008). In wildtype but not 5a-reductase knockout mice progesterone is necessary for lodosis. North-Eastern Undergraduate/graduate Research Organization for Neuroscience, CUNY-Hunter, New York, NY. Llaneza, D.C., Paris, J.J., Frye, C.A. (2008). Sex differences in cognitive and affective behaviors of intact or castrated rats with progesterone implants. North-Eastern Undergraduate/graduate Research Organization for Neuroscience, CUNY-Hunter, New York, NY. Paris, J.J., Frye, C.A. (2008). Infusions of bicuculline to the ventral tegmental area decrease exploratory, anti- anxiety, social, mating behavior, and 3α,5α-THP levels in naturally, sexually-receptive female rats.
  26. 26. North-Eastern Undergraduate/graduate Research Organization for Neuroscience, CUNY-Hunter, New York, NY. Walf, A.A. & Frye, C.A. (2008). Estradiol to ovariectomized rats enhances affective and sexual behavior and augments carcinogen-induced peripheral tumorigenesis. North-Eastern Undergraduate/graduate Research Organization for Neuroscience, CUNY-Hunter, New York, NY. Walf, A.A. & Frye, C.A. (2008). Estradiol to ovariectomized rats has dose-dependent effects for anxiety behavior and trophic effects in peripheral tissues. Anxiety Disorders Association of America Annual Meeting, Savannah, GA. Chin, I., Edinger, K.L., Walf, A.A., Paris, J.J., Rhodes, M.E., Frye, C.A. (2007). Rats in reproductive senescence show more anxiety behavior than do age-matched reproductively competent controls. Hudson Berkshire Society for Neuroscience Chapter, Albany, NY Cusher, D.S., Paris, J.J., Frye, C.A. (2007). Enhancement of 3a,5a-THP biosynthesis in the midbrain VTA of OVX/ADX/E2-primed rats increased exploration, anti-anxiety, and sexual behavior, and effects are attenuated by prior infusions of GABAA or NMDA antagonists. Hudson Berkshire Society for Neuroscience Chapter, Albany, NY Frye, C.A., Paris, J.J., Chittur, S. (2007). Microarray analyses of midbrain tissues from female mated and unmated rats indicates increased expression of genes involved in steroid biosynthesis, neurogenesis, dopamine receptor, and G-protein activity. Hudson Berkshire Society for Neuroscience Chapter, Albany, NY Llaneza, D.C., Paris, J.J., Frye, C.A. (2007). Infusions of 3a,5a-THP to the midbrain ventral tegmental area of OVX/ADX estrogen-primed rats increases exploratory, anti-anxiety and/or sexual behaviors via GABAA and/or NMDA receptors. Hudson Berkshire Society for Neuroscience Chapter, Albany, NY Paris, J.J., Rhodes, M.E., Frye, C.A. (2007). Administration or enhancement of 3α,5α-THP in the midbrain ventral tegmental area can overcome 3α,5α-THP inhibition and restore anti-anxiety and socio-sexual behaviors in cycling female rats. Hudson Berkshire Society for Neuroscience Chapter, Albany, NY. Babson, A., Koonce, C., Walf, A.A., Frye, C.A. (2007). The anti-anxiety and anti-depressant effects of estrogen administration to middle-aged rats is attenuated by estrogen deprivation for 5 months. Society for Behavioral Neuroendocrinology, 11th Annual Meeting, Asilomar, CA. Frye, C.A., Paris, J.J, Rhodes, M.E. (2007). Infusions to the ventral tegmental area of 3a,5a-THP overcome the reduction of exploratory, anti-anxiety, social, and sexual behaviors produced by inhibitors. Society for Behavioral Neuroendocrinology, 11th Annual Meeting, Asilomar, CA. Koonce, C., Walf, A.A., Frye, C.A. (2007). Estrogen receptor beta may be required for estradiol’s anti-anxiety effects in adult female mice. Society for Behavioral Neuroendocrinology, 11th Annual Meeting, Asilomar, CA. Walf, A.A., Frye, C.A. (2007). Dose-dependent anti-anxiety, anti-depressant-like and lordosis-facilitating effects of estradiol and SERMs. Society for Behavioral Neuroendocrinology, 11th Annual Meeting, Asilomar, CA. Walf, A.A., Frye, C. A. (2007). Estradiol has dose-dependent effects for anxiety, depressive, and social behavior and tumorigenesis in ovariectomized rats. Annual Graylyn Conference on Women's Cognitive Health, Wake Forest, NC. Babson, A.E., Walf, A.A., Paris, J., Frye, C.A. (2007). A chronic regimen of estrogen replacement to aged female rats enhances anti-anxiety, anti-depressive, and cognitive behavior. Society for Neuroscience, 37th Annual Meeting, San Diego, CA. Crain, C., Paris, J.J., Frye, C.A. (2007). 3α,5α-THP has actions in the hippocampus to modulate exploratory/anti-anxiety, social, and sexual behavior in female rats. Society for Neuroscience, 37th Annual Meeting, San Diego, CA. Dhalimbkar, S.V., Paris, J.J., Rhodes, M.E., Frye, C.A. (2007). Inhibition of 3α,5α-THP formation in hippocampus but neither cortex nor diencephalon of naturally-receptive female rats modulates exploratory, 26
  27. 27. anti-anxiety, and socio-sexual behavior. Society for Neuroscience, 37th Annual Meeting, San Diego, CA. Duffy, C.K, Paris, J.J., Frye, C.A. (2007). Parity influences cognitive performance in the object Placement and object recognition tasks. Society for Neuroscience, 37th Annual Meeting, San Diego, CA. Edinger, K.L., Ramos-Goyette, S.M., Gray, B., Frye, C.A. (2007). Northeast under/graduate research organization for neuroscience (N.E.U.R.O.N): the first year of the two conference model and our 11th and 13th conference for neuroscience trainees and educators. Society for Neuroscience, 37th Annual Meeting, San Diego, CA. Edinger, K.L., Walf, A.A., Frye, C.A. (2007). Androgens’ effects to enhance cognitive and affective behavior may be due to actions at estrogen receptor beta, not androgen receptors. Society for Neuroscience, 37th Annual Meeting, San Diego, CA. Frye, C.A., Paris, J.J., Chittur, S. (2007). Microarray analyses of midbrain tissues from female mated and unmated rats indicates increased expression of genes involved in steroid biosynthesis, neurogenesis, dopamine receptor, and G-protein activity. Society for Neuroscience, 37th Annual Meeting, San Diego, CA. Goldberg T., Koonce C., Walf A.A., Frye, C.A. (2007). Estrogen receptor beta is involved in estradiol’s anti- anxiety and anti-depressant-like effects in adult female mice. Society for Neuroscience, 37th Annual Meeting, San Diego, CA. Koonce, C., Walf, A.A., Frye, C.A. (2007). Progesterone improves cognitive performance and has anti- depressant-like effects in aged wildtype mice and transgenic mice that overexpress mutant forms of amyloid precursor protein and presenilin 1. Society for Neuroscience, 37th Annual Meeting, San Diego, CA. Maeng, S., Koonce, C., Walf, A.A., Frye, C.A. (2007). Progesterone has mnemonic effects in hippocampal and cortical learning tasks when administered to ovariectomized mice. Society for Neuroscience, 37th Annual Meeting, San Diego, CA. Paris, J.J., Rhodes, M.E., Frye, C.A. (2007). Administration or enhancement of 3α,5α-THP in the midbrain ventral tegmental area can overcome 3α,5α-THP inhibition and restore anti-anxiety and socio-sexual behaviors in cycling female rats. Society for Neuroscience, 37th Annual Meeting, San Diego, CA. Ryan, A., Koonce, C.J., Walf, A.A., Frye, C.A. (2007). Estrogen receptor beta may be required for estradiol’s effects to enhance cognitive performance of female mice. Society for Neuroscience, 37th Annual Meeting, San Diego, CA. Sumida, K., Frye, C.A. (2007). Effect of progesterone on depressive behavior of young, old and progestin receptor knockout mice in the forced swim test. Society for Neuroscience, 37th Annual Meeting, San Diego, CA. Vanderslice-Barr, J.L., Paris, J.J., Frye, C.A. (2007). Manipulating 3α,5α-THP Levels in late gestation alters anxiety and cognitive performance of juvenile offspring. Society for Neuroscience, 37th Annual Meeting, San Diego, CA. Wilming, C.R., Goldberg, T., Ryan, A., Maeng, S., Walf, A.A., Frye, C.A. (2007). Estrogen receptor beta knockout mice differ in their response to estrogen’s effects on conditioned place preference. Society for Neuroscience, 37th Annual Meeting, San Diego, CA. Youmans, S.Y., Frye, C.A., Walf, A.A. (2007). Progestin-facilitated lordosis of female rats may involve N- methyl-D-aspartic acid receptors (NMDARs) and mitogen activated protein kinase in the ventral tegmental area. Society for Neuroscience, 37th Annual Meeting, San Diego, CA. Chin, I., Edinger, K.L., Walf, A.A., Paris, J.J., Rhodes, M.E., Frye, C.A. (2007). Rats in reproductive senescence show more anxiety behavior than do age-matched reproductively competent controls. Univ Massachusetts Center for Neuroendocrine Studies, 9th Symposium, Amherst, MA. Cusher, D.S., Paris, J.J., Frye, C.A. (2007). Enhancement of 3α,5α-THP biosynthesis in the midbrain VTA of OVX/ADX/E2-primed rats increased exploration, anti-anxiety, and sexual behavior, and effects are attenuated by prior infusions of GABAA or NMDA antagonists. Univ Massachusetts Center for Neuroendocrine Studies, 9th Symposium, Amherst, MA. Kim, S.H., Cusher, D.S., Paris, J.J., Frye, C.A. (2007). GABAA and NMDA receptors are important in

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