Congenital Hypothyroid Screening among Low Birth Weight Infants, Michigan, 2005-2007 Steven J. Korzeniewski, MA, MSc, Maternal & Child Health Epidemiology Section Manager Violanda Grigorescu, MD, MSPH, William I. Young, Ph.D. Bureau of Epidemiology, Division of Genomics, Perinatal Health and Chronic Disease Epidemiology
Preliminary Findings of the CH Three year follow-up study
Preliminary findings indicate:
47% (9/19) of cases with completed diagnostic re-evaluation to date appear not to have permanent CH.
A surprising number of patients (families) have stopped treatment of their own accord (7/23 with completed follow-up); this phenomenon requires further study.
One case (family) described miscommunication with health care provider and lack of follow-up as impetus to treatment cessation.
While all patients who stopped treatment on their own are thought to be transient CH (confirmation of transient CH is pending TSH value receipt- two patients have provided such confirmation to date), only 2/12 cases evaluated by an endocrinologist/hcp are considered transient.
This finding may have implications for the method of diagnostic re-evaluation.
Some cases were confirmed based on increasing treatment dosage at approximately 6 months of age; should this preclude three year thyroid challenge?
Questions remain about process and outcome of three year CH re-evaluation.