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Annual Report.doc

  2. 2. Table of Contents Page Departmental Report 3 I. Changes in Environment 3 II. Compact Plan 3 III. Diversity 3 IV. Instructional Program 9 V. Faculty 17 VI. Students 18 VII. Research 19 VIII. Administration and Staff 19 IX. Recommendations and concerns for the future 20 X. The University’s Five Focus Areas 23 Appendix I List of Faculty/EPA Employees Including Graduate Students 27 Appendix II List of Administrative and Staff Personnel 28 Appendix III Courses Offered by Departmental Faculty Including DVM courses Presented by Departmental Faculty and Graduate Courses Offered by and Participated in by Departmental Faculty 31 Appendix IV Clinical Service Offered by Departmental Faculty 33 Appendix V Publications, Presentations, Intellectual Property by Departmental Faculty 61 Appendix VI Professional Activities by Departmental Faculty (Includes Memberships on Research Grant and Study Reviews, Memberships on Editorial Boards, and Ad hoc Manuscript Reviews, Committee Memberships within MBS, CVM, NCSU, and National Committees 73 Appendix VII Research Grants Awarded to Departmental Faculty 2
  3. 3. I. Change in Environment Faculty retirement: N/A Faculty resignations: Linda Martin; Assistant Professor of Cell Biology; July 1, 2008 Anthony Pease; Assistant Professor of Radiology; September 2, 2008 Doodipala Reddy; Assistant Professor of Neuroscience and Pharmacology; July 2, 2008 Faculty hires: Gabriela Seiler; Associate Professor of Radiology; appointment begins July 1, 2009. We currently have one faculty position open for identified needs in Pharmacology. We are unsure about whether we will be allowed to recruit for this position because of the current budget situation. We have already lost the Stem Cell position that we had begun recruitment for last year. We are anticipating serious budget cuts at the State level which will negatively impact the department. At this point in time we do not know how much of our budget is in jeopardy. This will be a major challenge for the Department and College moving forward. II. Compact Plan: For 2008-2010 the Compact Plan was developed at the College level. III. Diversity Kenneth Adler has been awarded a supplement to his NIH grant for “underrepresented minorities” for Ms. Teresa Green, a graduate student in his laboratory. Prema Arasu, within context of diversity strategies as defined by NCSU Office of Diversity, ( odi/initiatives/Diversity_Advisory.pdf), has: helped coordinate outreach seminars focused on livestock production/biofuels/health with NCSU faculty and students and external stakeholders (through USDA funded award; teamed with CVM Faculty Maria Correa and Isabel Gimeno and CALS faculty Vivek Fellner and Ratna Sharma); served as advisor for newly formed “Minority Association for Pre-Medical Students” Fall 2008; in the process, Dr. Arasu consulted with Dr. Anita Flick and we agreed that this group of students was better served by coming under the umbrella of the NCSU Pre-Health Club. From this experience, Dr. Arasu was also able to help College of Humanities and Social Sciences via Dean Jeff Braden to link with the Pre-Health Club and establish a new chapter for students interested in careers related to mental health (Dr. Arasu served only in facilitating role); served as advisor and coordinator for two undergraduate students interested in international health experiences - one worked with Public Health Foundation of India in New Delhi, India over the summer 2008; contributed to article on CVM women in science and health for regional news magazine, Women’s Edge; completed term (07/08) as advisor to university Graduate Student Association; served as NCSU representative to Research Triangle Global Coordinating Council (organized by RTRP Doug Aitkin/Ted Abernathy); serving on NCSU College of Management Biosciences Management/Industry (external) Advisory Board; connected NCSU CVM as a partner with the national Alliance for Oral Contraception of Cats and Dogs, and with the Global Alliance for Rabies Control. Jill Barnes has contributed to improving diversity: Member, Ad-Hoc Diversity Committee (NCSU CVM); Attended “Advising students of color” workshop April 19; USDA, Veterinary Career Pathways Program, May 2008, mentored six minority students in the program in veterinary anatomy “short course”, consisted of 5 weeks of 7 hrs of instruction/week on the limbs/ thoracic cavity /head /abdominal cavity; SAVE program, NC A&T students, heart dissection lab; won the NCSU Faculty Diversity Award, 2009. Gregg Dean participated in DVM admissions, molecular biology training program, DVM/PhD training program, and GAANN program. Recruited and hired undergraduate minority student, objective is to provide mentorship prior to application to DVM program and participated in ‘Advising students of color’’ workshop April 2008. 3
  4. 4. Troy Ghashghaei has hired and advised students, postdocs, and technicians from multiple ethnic backgrounds: Raul Salinas-Mordagon (Technician; Hispanic), Benjamin Jacquet (Ph.D. Student; Belgian), Jihey Lim (Postdoc; Korean), Atif Sheikh (undergraduate; Pakistani background), and Huixuan Liang (Ph.D student; Chinese). He also has an equal distribution of male-to-female ratio in the laboratory. Jorge Piedrahita is a Co-PI in an NIH training grant to bring minority undergraduate and graduates into sciences (PI - Trudy McKay). Program is Initiative for Maximizing Student Diversity (IMSD; He is a member of the steering committee and of the admission committee for this program. Dr. Piedrahita participated as a panel member for the BFF (Building Future Faculty) program. Barbara Sherry serves on the Executive Committee for Expanding Your Horizons Workshops, Spring 2009. NCSU invites 400 seventh grade girls, with an emphasis on those from under-represented groups, to participate in a single-day conference to encourage their pursuit of scientific careers. Dr. Sherry organized participation of 60 -100 of the girls at the College of Veterinary Medicine, for workshops developed by colleagues. We scheduled a record 9 workshops at the College of Veterinary Medicine for March 3rd 2009, but unfortunately the conference was cancelled the day before due to snow! IV. Instructional Program Initiatives including curriculum development and program review Curriculum Development MBS faculty are actively involved in the ongoing curricular review and revision. Efforts have been made by faculty to develop and introduce teaching innovations to enhance student problem-solving and communication abilities. This is particularly evident in the selective courses taught at the end of each semester, which provide a variety of offerings, which expand flexibility in the curriculum and new and varied experiences for students. We are continuing to work on changes within existing courses to incorporate molecular medicine into the curriculum. We are continuing to work on the Physiology course (VMA 913 and 923) to include genomics and molecular medicine concepts, as well as to better align the subject matter in order to match more closely with Anatomy. Prema Arasu participated in CVM sub-committee (FCCCE, Subgroup Core led by Dr. Jennifer Neel) on CVM core curriculum reform/assessment. She formed working group to develop a public heatlh focus/courses/track at the undergraduate level at NCSU; applied for sponsorship and was awarded paid slot to attend the July 2008 AACU “The Educated Citizen and Public health” workshop in Crystal City, Virgina/DC (helped obtain matching support from Provost's office and attended workshop together with Dr. Maria Correa, CVM; Gerry Luginbuhl, CALS; Maxine Thompson, CHASS). Our efforts have culminated in the development of the first course, GPH 201, Global Public health, which will be offered by the Dept of Biology, CALS, as an inquiry course in Fall 2009. The second course proposed is a basic course in epidemiology/biostatistics. She formed working group across 6 colleges to develop a Master’s in Development Practice (similar to International Development); co-wrote and submitted pre-proposal to MacArthur Foundation for funds to establish the program with Dr. Heidi Hobbs. We were invited to submit a full proposal but decided to partner with TERI India and other global partners for a stronger application; pending decision on support (Lead at NCSU will be Dr. Heidi Hobbs, Director of the Master in International Studies, CHASS); proposal pending. Dr. Arasu is also working with Heidi Hobbs to develop a professional science master's focused on international development (bridging life sciences, natural sciences, social sciences and management). New course at Ohio State University based on 1 week selective "International Veterinary Medicine" at NC State University CVM. Dr. Arasu delivered a guest lecture on Dec 15, 2008, by videoconference to veterinary students at Ohio State University (course coordinator Dr. Wondwossen Gebreyes). Jill Barnes is developing a summer workshop “Canine Anatomy” designed to aid in transition of incoming freshman students into the professional program. 4
  5. 5. Matthew Breen is serving his third year on the FCCCE, which has begun a complete reevaluation of the DVM curriculum at NC State. The activities of this committee required a considerable effort as we moved toward a faculty driven outline for change. Gregg Dean has developed comparative medicine and translational research training program for specialty trained post-DVM PhD candidates. Lloyd Fleisher is an ex officio member of the CVM Curriculum Committee, he has been actively involved in a major revision of the Veterinary teaching curriculum. Dr. Fleisher also serves on a subcommittee charged with devising novel testing paradigms for the new curriculum. John Gadsby wrote 2 new lectures “Introduction to Endocrine Pharmacology” and “Drugs affecting Reproduction”, and presented them in VMB933 Veterinary Pharmacology as a guest lecturer, Fall 2008. Troy Ghashghaei initiated the development of a new format of teaching the Neurophysiology portion of the Physiology course in the first year DVM curriculum. Jon Horowitz developed and was the course coordinator of a new four credit graduate course “CBS771: Cancer Biology” that was completed by thirteen students in the Fall of 2008. This course was taught by six professors, two from MBS and four from the Dept. of Environmental and Molecular Toxicology, and received very strong evaluations from participating students. Dr. Horowitz wrote and presented 40% of the lectures in this course. Lola Hudson - development/initiation of a new on line course in conjunction with Drs. Klesath (Zoology), Hardie, and our medical illustrator. This course is intended to ascertain that incoming students have a certain level of anatomical knowledge and medical terminology before they enter the rigorous professional curriculum. This course was offered in summer of 2008 and Dr. Klesath has received grade information from Dr. Hudson on the veterinary classes being compared for statistical analysis. Chris McGahan continues to redesign curriculum in Veterinary Physiology. Mark Papich serves on the College Curriculum Committee (FCCCE) (term started in the fall of 2007) as the department representative. This committee has been charged with reviewing, reorganizing, and proposing changes in the DVM curriculum to better prepare our future veterinarians. This committee meets every two weeks and the focus on curriculum evaluation will continue into next year. In 2009, Dr. Papich published a new edition of a long-standing textbook for teaching veterinary pharmacology. He was one of the editors for the book, Veterinary Pharmacology and Therapeutics, 9th Edition, Wiley-Blackwell Publishing, Ames, Iowa, USA, 1524 pages; 2009. This book is now in its 9th edition and is a standard textbook for teaching veterinary pharmacology to students. In 2009, Dr. Papich was one of the consulting editors for the book, Kirk’s Current Veterinary Therapy XIV, edited by Bonagura JD & Twedt DC, Saunders-Elsevier. This book is a widely-cited clinical textbook used by students, now in its 14th edition. Lysa Posner serves on the subcommittee for PBL (Problem Based Learning), 2008-2009. Ian Roberston’s ongoing improvement of VMB 976 course, for which he is the supervisor, involved generating extensive online quiz material via Blackboard Vista and generating other self directed learning resources. Korinn Saker participated in meetings and discussion groups here at NCSU-CVM pertaining to development of the Wellness Training Program for DVM students. Dr. Saker also participated in the Deans Forum – Innovations in Education (November 2008) to discuss important issues that impact the veterinary curriculum. 5
  6. 6. Cliff Swanson was an invited participant and facilitator, AAVMC Educational Symposium, Washington DC, March 13-15, 2008. Jeff Yoder, as course director for CBS565 Fundamentals of Biomedical Sciences, over the past 4 years, has gained an appreciation for the different educational backgrounds that the incoming CBS graduate students bring with them. It became clear that many students lacked an understanding of multiple standard cellular and molecular methods used in biomedical research. As co-course directors, Dr. Matthew Breen and Dr. Jeff Yoder have developed a new 1-credit graduate course to be offered every fall starting in 2009 (currently waiting approval from the Administrative Board of the Graduate School). This course, CBS570, Methods in Biomedical Sciences, will provide a 1 hr lecture each week on a variety of standard methods. Dr. Yoder will be providing lectures on DNA/RNA/protein analyses, PCR, cloning cDNAs, expression constructs, transgenesis, gene “knock- out” models and flow cytometry. Dr. Yoder, as course director for CBS565 Fundamentals of Biomedical Sciences, over the past 4 years, has concluded that the overall course topics and lecture schedule in CBS565 needed to be rethought and reorganized. At a meeting of the teaching faculty for this course, it was agreed that more focus and continuity was needed for the lecture topics and a task force committee was appointed. When this committee met, it was agreed that each of the 5 Concentration Areas within CBS (Cell Biology, Pathology, Pharmacology, Infectious Disease and Population Medicine) should have equal representation in this course. Thus each Concentration Area Leader will be responsible for deciding the 4-5 lecture topics to be included in CBS565 and will identify the appropriate faculty members to present the lectures in this course. We will be implementing these modifications in the fall of 2009. Clinician Scientist Focus Area (CSFA) has been a departmental initiative which continues to develop and grow. Prema Arasu - served as Chair, Steering Committee, One Health Intellectual Exchange Group - committee convened in September 2008; inaugural seminar in January 2009 with subsequent, one seminar a month held at NC Biotechnology Center, targeting students in veterinary and human medicine ( as well as graduate students, public health) from NCSU, Duke, UNC. Dr. Arasu was responsible for selecting topics and speakers. Matthew Breen is the leader of the Clinician Scientist Focus area and as such has continued to identify research oriented DVM students that could be encouraged to become involved in research activities at NCSU. Dr. Breen meet with the enrolled CSFA students one:one on a regular basis to gauge their feel for the program and to monitor their progress in the research aspects of their DVM program. Gregg Dean provided a research experience as a selective for Austin Duncan a freshman DVM student. John Gadsby, coordinator (and presenter) of “Research in Reproduction” research day within the one week “Introduction to Research at CVM” selective (VMB 990D) – Fall 2008. Korinn Saker developed a feline mammary gland organ culture system to evaluate chemotherapeutic and selected nutrients. Dr. Saker also developed and procured funding for two educational programs in Clinical Nutrition. i) IAMS Rotating Nutrition Internship – a 1-year internship training in small animal disciplines as well as small animal clinical nutrition. Initial funding is for 2 years. ii) Nestle Purina Clinical Nutrition Residency – a 2-year clinical training program here at NCSU-CVM. Introduction to Research at the CVM “Introduction to Research at the CVM” (VMB 991D) is offered in the fall semester as a one-week selective and will be required for all students interested in the CSFA. Students are expected to take this selective in the fall of the 1st yr of the DVM curriculum. This selective will be open to any student interested in exploring the possibility of choosing the CSFA. All three departments participate in this Focus Area. In this selective, mentors in the different areas of clinical and basic research experience will present a summary of ongoing projects in their laboratories. This selective will be divided into identifiable areas of research based 6
  7. 7. on the group of participating mentors (i.e. oncology, neurology, therio, etc., ideally combining both basic and clinical aspects of research), with each group responsible for presenting their area of interest to the students. Students will be required to interview briefly with three potential mentors during the time of the selective. Students will also be required to prepare a personal statement indicating their personal and academic goals, their reasons for choosing the CSFA, and their reasons for pursuing a particular mentor opportunity. Other Selectives will be chosen based upon the career goals and research interests of the individual student, in consultation with their primary mentor and committee. Students are encouraged, although not required, to take additional research-related selectives (i.e. Molecular Medicine Initiative selectives such as Trangenics, Developmental Toxicology and Teratology and VMB 992E Biomedical Research Experience). Students choosing the Clinician Scientist Focus Area (CSFA) will also declare a clinical interest (equine, small animal, pathology, food animal, mixed animal, epidemiology and public health, laboratory animal) that will give them priority in clinical rotation scheduling equal to that of students declaring a specific clinical focus area. The clinical interest must be declared by the end of the second year. Alternatively, CSFA students may, in consultation with their guidance committee, create a required list of clinical senior rotations. CSFA students will then be given top priority for these rotations. This list much also be completed and approved by the guidance committee by the end of the second year. The following MBS Faculty members are available as mentors in this program: Arasu, Prema Degrees/expertise: PhD, DVM We use dog hookworm parasite as our model to study host-pathogen interactions and developmental aspects of the hookworm nematode. Research in the lab spans the breadth of clinical, animal-based questions to basic research approaches using genomics, molecular biology, immunology, cell biology and the mouse model. For example, one project in the lab is focused on the pregnancy-induced reactivation and transmammary transmission of hookworm infection to nursing puppies. What is the signaling mechanism between the underlying molecular mechanisms and identify strategies of preventing this route of pathogen transmission? Barnes, Jill Degrees/expertise: DVM, PhD My laboratory investigates the role of stress protein expression and it's impact on the development and treatment of breast cancer. Students would be exposed to a number of cellular and molecular techniques such as cell culture, transfections, DNA, RNA and protein isolation, real-time PCR, Western analysis, reporter assays and flow cytometry/cell cycle analysis. Breen, Matthew Degrees/expertise: PhD, C Biol, MI Biol Chromosome aberrations are hallmarks of the instability of the tumor genome. Our research program is focused on the cytogenetics of canine cancers. In particular we have developed molecular cytogenetic tools and reagents that allow us to interrogate canine tumors (individual tumor cells and tumor cell populations) to reveal recurrent chromosome aberrations. We work closely with clinicians and pathologists so that we are able to correlate cytogenetic findings with clinical features such as tumor subtype, tumor progression, response to therapy etc. In this way we have begun to identify chromosome changes in canine cancers that have both diagnostic and prognostic significance. As a consequence we are a) working towards offering the clinician a means by which to improve the sophistication of clinical management of dogs with cancer and b) developing a better understanding of the genes involved in cancer initiation and progression, which may ultimately lead to improved therapies. Dean, Gregg Degrees/expertise: DVM, PhD, DACVP Students will be exposed to in vitro and in vivo work. Mice and cats are used to evaluate immunological responses to novel vaccine strategies and cats are used in the study of feline immunodeficiency virus. Students may be involved in collecting and processing samples, immunological and virologic assays, and numerous molecular techniques. Specific assays may include flow cytometry, ELISA, ELISpot, western blot, cloning, PCR, bacterial culture, cell culture, and bioassays. 7
  8. 8. Gadsby, John Degrees/expertise: PhD Students could be exposed to animal surgeries (ovariectomies and ovarian infusions), tissue dissociation, cell isolation/separation and cell culture, steroid and peptide hormone analysis (RIA or ELISA), enzyme activity (protein kinase C) assays, mRNA extraction and analysis by RT-PCR, protein extraction and analysis by Western blotting, microarray analysis and possibly RNA interference (in the near future). Specifically he could partner with Theriogenology (he already collaborates with Carlos Pinto) or Swine (he also collaborates with Glen Almond) faculty. McGahan, Chris Degrees/expertise: PhD The focus of my laboratory is the study of the metabolism of iron in ocular tissues. We are investigating iron uptake and storage in lens and retinal pigmented epithelial cells. These investigations include measurements of a labile pool of iron within the cytoplasm that is thought to be available for participation in generation of free radicals and subsequent cellular damage. It is therefore essential to understand the regulation of the size of this pool, which at this point is almost completely unknown. We are also determining how alterations in the subunit composition of the iron storage protein, ferritin, affect iron storage and the size of the labile iron pool. Tied in with these basic studies of iron movement within cells are investigations into iron’s roles in regulating basic metabolic pathways, including the production of the excitatory neurotransmitter, glutamate. The clinical importance of understanding iron metabolism in the eye is underscored by the fact that dysregulation of iron metabolism and resulting free radical damage have been implicated in cataract formation and in retinal degeneration. Piedrahita, Jorge Degrees/expertise: PhD Dr. Piedrahita's laboratory is primarily interested in understanding the role of imprinted genes in embryo development and in disease, and in the development of transgenic animals for use in human and veterinary medicine, and in agriculture. Towards this end, his laboratory combines techniques in functional genomics, cell biology, embryo manipulation, and molecular biology. Specifically, students would be introduced to a range of recombinant DNA, and genomic technologies as they relate to a clinically-relevant phenotype. Contributions to Selectives: Prema Arasu, Course coordinator for International Veterinary Medicine, 1 week selective, Fall 2008; Course coordinator for “Animal Acupuncture: China”, two week course at Zhejiang University, Hangzhou, May 2008. Makoto Asakawa supervised first, second and third year students in anesthesia selective. Matthew Breen re-offered the full week selective, “Introduction to Research at the CVM” (VMB991D), providing a group of 15 DVM students with a ‘taster’ of the range of research activities ongoing at the CVM. The course is team-taught and covers a variety of research exposures. Dr. Breen met with the class each day and spent time reviewing the course, which allows the development of a good rapport with the students. At the end of the week we have a frank discussion about the good and bad aspects of the course and this session also serves to identify those students who have developed a real thirst for research. Dr. Breen arranged to meet with these students in the following weeks and then seek to match them with a faculty mentor who will help them gain more experience with their developing research interest. Nigel Campbell, VMC 992Z Active Learning in the VTH (students become an active member of the Clinical Anesthesia Service for 2 weeks). John Gadsby, coordinator (and presenter) of “Research in Reproduction” research day within the one week “Introduction to Research at CVM” selective (VMB 990D) – Fall 2008. Jon Horowitz presented a single hour-long lecture in an ongoing selective (VMB 991E Section 004: Transgenics). Nanette Nascone-Yoder, VMB 992 - Developmental Toxicology and Teratology. 8
  9. 9. Jorge Piedrahita, VMB991E Transgenics, participating faculty; Reproductive Selective, participating faculty. Lysa Posner, VMC 991 Primate Medicine, Anesthetic concerns for Primates, 1 hr, April 2008 Korinn Saker, developed the syllabus and course program for: Advanced Small Animal Clinical Nutrition – offered in Fall 2008 and Spring 2009, and Equine Nutrition – offered Spring 2009. Ed Smallwood continues to offer and teach VMB 991G, Avian Anatomy. Jeff Yoder, VMB991E Transgenics, course director; VMC991Q Fish Medicine, participating faculty. A listing of courses presented by MBS faculty in the professional curriculum and graduate courses presented by MBS faculty can be found in Appendix III (p. 28). MBS Selectives taught by MBS faculty Faculty Semester Title Breen Fall Introduction to Research at the CVM (VMB991D) Khosla Fall Histologic Techniques in Health (VMB991B) Arasu Fall//Spring International Veterinary Medicine (VMP991Y) Arasu Fall/Spring International Veterinary Medicine Experience (VMB991S) Hudson Spring Veterinary Medicine and Farriery (VMB991I) Nordone Spring Immunodiagnostics (VMB991B) Smallwood Spring Avian Anatomy & Physiology (VMB991G) Yoder Spring Transgenics (VMB991E) Program Reviews MBS faculty are actively involved in the ongoing curricular review and revision. Efforts have been made by faculty to develop and introduce teaching innovations to enhance student problem-solving and communication abilities. This is particularly evident in the selective courses taught at the end of each semester, which provide a variety of offerings, which expand flexibility in the curriculum and new and varied experiences for students. V. Faculty Honors Accomplishments of MBS faculty have been recognized at national, international, state and campus levels. Documentation of several faculty invitations and recognition’s of scholarly activity, not included below, can be found in Appendix VI (p. 61) that includes memberships on editorial boards, ad hoc manuscript reviews, and membership on research grant and study reviews. Kenneth Adler NIH NHLBI MERIT Award (5 R37 HL-36982): 2004 – 2014 Prema Arasu Invited to serve on review panel for USDA International Science and Education Program. Reviewed 15 proposals and spent two days in Washington D.C. for the final selection process (March 17-18, 2009). Jill Barnes Nominated for the Alumni Distinguished Undergraduate Professorship Award for the CVM Winner NCSU Faculty Diversity Award 9
  10. 10. John Gadsby Chair of the Triangle Consortium for Reproductive Biology (TCRB) for 2009-2010. Major role is the organization of the 2010 annual meeting to be held at NIEHS, RTP, February 2010 Chris McGahan Member, National Advisory Eye Council ARVO Fellow, Silver level, inducted April 2009 Shila Nordone Fort Dodge Research Scholar 2007- September 2008 Mark Papich Huffman Leadership Award, in recognition of outstanding contributions to NC State University College of Veterinary Medicine, 2008. Pfizer Award for Research Excellence, for outstanding achievement and dedication in the field of Veterinary Medicine, 2008. Jorge Piedrahita NIH Study Section, DEV-1 NICHHD, Regular member, October 2006-2010 Philip Sannes College recipient of the Board of Governors’ Award for Excellence in Teaching Outstanding Teacher Award. Barbara Sherry Received the Alumni Distinguished Graduate Professor award in May 2008 for leadership efforts in helping to develop and lead the university-wide Genomic Sciences graduate program. There are only two of these awards presented each year across the entire university. Accomplishments related to research efforts: (Does not include grants and publications which are listed in Appendix VII (p. 73) and Appendix V (p. 33). Kenneth Adler - A start-up company (BioMarck) that has been licensed through the NCSU technology transfer office has developed a drug based on technology from his laboratory. The drug has been approved by the FDA and is to be tested in human patients suffering from chronic bronchitis starting at the end of April 2008. Phase 2a studies have been started and the first cohort of patients has been finished…data from this cohort will be available in four weeks (end of May). Prema Arasu - Efforts are focused on building multidisciplinary teams (across NCSU colleges and building on life science strengths of CALS and CVM) in area of food safety and security, and zoonotic/emerging diseases. Matthew Breen - During the current reporting period, continued to grow the lab and to explore means to engage other CVM faculty in a broader programmatic effort. As part of this initiative, was nominated and subsequently elected a full member of the UNC-CH Lineberger Comprehensive Cancer Center. This status allowed application for funds through the UCRF mechanism which resulting is a collaborative grant being awarded to Dr. Kristy Richards (UNC), Dr. Steven Suter (DOCS), Dr. Alison Motsinger-Reif (Statistics) and Dr. Breen. This brought valuable UCRF dollars to the CVM and we anticipate that this funding will continue over the coming years. In addition to a number of ongoing funded projects in the lab, Dr. Breen has been awarded $530,000 in new extramural grant income during this annual reporting period. Research activity in this past year has led to 14 peer-reviewed publications in quality journals. On 11 of these Dr. Breen is the senior, co-senior or first author. During the reporting year work has been featured several time on the CVM and NCSU website and also picked up by the local and national media. Editorials/commentaries about recent published findings that human and dogs share evolutionarily conserved genomic changes in comparable cancers appeared in Nature Medicine and the Journal of the National Cancer Institute. Gregg Dean - Determined dendritic cell function is compromised by FIV function. Identified strains of lactobacillus that can be used to induce tolerance and others that can be used as vaccine vectors. Cloned two autoantigens associated with canine blistering skin disease. Determined effect or regulatory T cells on FIV disease pathogenesis. John Gadsby - Major progress made in a study designed to determine the temporal and spatial patterns of expression of Endothelin (ET)-1, Endothelin Converting Enzyme (ECE)-1 and ET-receptors (A & B) within the porcine CL throughout the estrous cycle. Major progress made in a study desigend to examine the role of protein kinase C (PKC) in the mechanism by which porcine CLs become sensitized to the luteolytic actions of PGF-2l in vivo and in vitro. Major progress was made in the study designed to determine the temporal and spatial patterns of expression of TGF- ligands, receptors and Smads in peri-ovulatory porcine follicles. These data suggest that LH and TGF-. act together to promote luteinization of porcine follicles. Major progress was made in the study to determine the temporal and spatial patterns of expression of apoptosis-associated genes in the porcine CL throughout the estrous cycle. Major progress made in studies to examine 10
  11. 11. the effects of uterine infectious disease on ovarian function in cattle: This NEW project initiated during Dr. Gadsby’s sabbatical leave in the lab. Jon Horowitz - Co-coordinate a new high school, undergraduate, and graduate training program in cancer research (Jimmy V-NC State Cancer Therapeutics Training Program). This program has recruited four graduate students, four undergraduates, and four high school students, and these students are being trained in various aspects of cancer research. This novel training program has been featured on the NCSU home page, in the NCSU alumni magazine, in the NCSU graduate school's Results magazine, and the CVM magazine. Lola Hudson - Continuation of NIH subcontract, submission of an R21 as PI, and submission (in preparation) of an administrative supplement subcontract, one manuscript published, and one submitted (first author). The latter was rejected and is being rewritten with reviewers’ comments and suggested additional experiments as a guide. Chris McGahan - Received supplement to NIH grant #04900-27, to support the purchase of an hypoxia chamber which will allow for the development of preliminary data for the R01 competitive renewal in 2010. Three papers were presented at meetings this past year. Dr. Goralska presented a paper at the International Society for Eye Research meeting in Beijing and another paper at the Cell Biology meeting in New Orleans. Dr. McGahan presented a paper at the annual Association for Research in Vision and Ophthalmology in Ft. Lauderdale. Nanette Nascone-Yoder - Invited presentation at Southeast Regional Society for Developmental Biology meeting, April 2008, “Basolumenal endoderm intercalation: A geometrically unique execution of convergent extension during gut tube elongation”. Invited presentation at University of Miami, Biology Department Seminar Series, 2008, “Mechanisms of endoderm morphogenesis: a gut reaction”, Miami, FL. Mark Papich - Fourteen new research manuscripts published in refereed journals. Five research abstracts were presented at National meetings and conferences and one was presented at the NCSU Annual Research Forum. In addition, four new research projects have been funded and two others submitted and are pending. Jorge Piedrahita - One active R10, one active R21 as PI, one active R21 as co-PI, an active USDA and a pending R01. Published four articles and two review papers this year. In addition, have two manuscript presently being reviewed (already submitted) and two in preparation. Given four invited presentations this year and have three additional invitations for the remaining of 2009. Two of those are international conferences. Lysa Posner - Developed a model to study analgesic efficacy in teleost fish. Philip Sannes - Recipient of NIH Director’s Bridge Award (R56). Barbara Sherry - Invited to deliver a State-Of-The-Art platform presentation on Innate Immunity at the 27th annual American Society for Virology meeting, July 12-16, 2008, Cornell University, Ithaca NY. Rachael Thomas - Received Morris Animal Foundation Established Investigator Funding Award in feline genomics – proposal ranked in 1st quartile. Successfully completed two-year Morris Animal Foundation First Award in feline genomics. Profiled as one of “Tomorrow’s PI’s” by Genome Technology Online. Elected as a full member of the Center for Comparative Medicine and Translational Research. Published five peer-reviewed papers, three as first author, two as second author. Two further first author papers in preparation (for imminent submission). Contributing author on five abstracts accepted for presentation at international canine genomics conference (one as first author, invited for an oral presentation). Exceeded self-assigned goal of analyzing 30 feline sarcoma cases by microarray-based technology (currently 42 cases). Identified potential new diagnostic factors for feline sarcoma. Developed novel feline injection-site sarcoma cell-line. Exceeded designated goal of analyzing 100 canine lymphoma cases by microarray-based technology (currently 124 cases). Developed and implemented revised protocols for genomic microarray analysis, resulting in significant cost and time saving and improved data quality and consistency. Published first insight into karyotypic conservation between canine and human brain tumors. Successfully guided undergraduate research assistant through laboratory component of honors research program. Continued training and supervision of graduate research assistant. Continued informal day-to-day responsibility for guiding and overseeing graduate research student. Continued role as 11
  12. 12. informal technical advisor to laboratory personnel. Continued role as co-ordinator of clinical samples and data for canine lymphoma and brain tumor studies. Ad-hoc manuscript reviewer for Journal of Heredity and Veterinary Pathology. Invited reviewer of America Kennel Club Canine Health Foundation funding awards Jeff Yoder - Trainer for NCSU/NIH “Biotechnology Training” Grant. Trainer for proposed CVM/NIH “Interdisciplinary Biomedical Research Training Program for Veterinary Students” training grant. Research Achievements and Honors of Trainees: Kenneth Adler - Program Manager for cooperative agreement between NCSU and the U.S. EPA that provides support for numerous graduate students and postdoctoral trainees to work on collaborative projects between the 2 institutions. Prema Arasu - Advisor to Rushil Patel, Undergraduate Honors Project - worked with her to review literature and write a paper on Zoonotics Diseases in the state of Gujarat as representative of the profile of zoonotic diseases in India. Dr. Arasu also provided Rushil Patel with the linkage for an externship at the Gujarat State Department of Health and participation in the Zoonotic Diseases workshop held in Delhi in June 2008. Matthew Breen - Dr. Stephanie Montgomery (DVM Class of 2011) was awarded a Morris Animal Foundation Scholarship to allow her to work in the lab during the Summer of 2008. Dr. Montgomery will present her work at the MAF Annual Meeting in Denver, June 2009. Dr. Benoit Hedan (PostDoc in my lab) was selected as the 2009 Recipient of the Bob Kelley Young Investigator Award for his presentation at the international meeting Genes, Dogs, Cancer, Florida, 2009. Gregg Dean - Rochelle Mikkelsen: Awarded Keystone Symposium Travel Scholarship and a platform presentation to the HIV Pathogenesis meeting, April 2008. John Gadsby - Leah Zorrilla (fomer graduate student) has had one paper published, two papers submitted as first author and has one paper in press as co-author. Raja Sriperumbudur (former graduate student) has one paper in press as first author, and one submitted as co-author. Jon Horowitz - An undergraduate trainee, Bridgid Hast, was accepted into graduate school at UNC-Chapel Hill and has already contributed to a manuscript published in Nature Medicine. A graduate trainee, Tae-Hyung Kim, has generated a series of transgenic mouse lines and is in the process of characterizing their phenotypes. A poster describing some of this work won second prize at the 2009 CVM Research Symposium. Mr. Kim was nominated as a trainee in the Jimmy V/NCSU Cancer Therapeutics Training Program and was accepted. A graduate trainee, Haifeng Yin, generated a conditional "knockout" mouse line and has characterized several extremely interesting phenotypes resulting from inactivation of the gene of interest. Mr. Yin will graduate with a PhD in 2009. A graduate trainee, Jianzhen Xie, characterized the expression of a gene of interest in early development and documented the differential expression of this gene in adult tissues. An undergraduate trainee, Tojan Rahhal, joined the laboratory, was nominated as a trainee in the Jimmy V/NCSU Cancer Therapeutics Training Program and was accepted. Nanette Nascone-Yoder - Two undergraduate research students (Mandy Womble, Meredith Parr) presented posters at the NCSU Undergrad Research Symposium in April 2008. Mandy Womble won best poster award in the Molecular Biology, Biochemistry, Genetics, and Cell Biology category. Both of these undergraduate students also presented their posters at a National Society for Developmental Biology meeting at the University of Pennsylvania (Philadelphia) in July 2008. Meredith Parr won the award for Best Undergraduate poster at this national meeting. Graduate student Stephanie Bloom presented a poster at the National Society for Developmental Biology meeting at the University of Pennsylvania (Philadelphia) in July 2008. Stephanie was selected to give an oral presentation at the annual CVM Research Symposium, and a platform (oral) presentation on her work at the Southeast Regional Society for Developmental Biology conference, University of Alabama (Birmingham, AL), March 2009. Graduate student Allison Morckel presented a poster on her work at the Southeast Regional Society for Developmental Biology conference, University of Alabama (Birmingham, AL), March 2009. Mark Papich - Katherine Tolbert, Resident in Small Animal Internal Medicine, NCSU-CVM. Winner of the 2009 CGS/Waltham Research Grant competition. Awarded for the study “Efficacy of oral omeprazole formulations for the 12
  13. 13. control of intragastric pH in dogs. Co-investigators (mentors), include Drs. S. Bissett, J, Gookin, and MG Papich. First place award at the ACVIM Forum, 2008 in Neurology to: Sarah Moore (Internal Medicine Resident) for her presentation: “The pharmacokinetics of levetiracetam in healthy dogs following single and multiple oral doses. [Abstract #83] 2008 ACVIM Forum, San Antonio, Texas. First place award at the ACVIM Forum, 2008 in Neurology to Dr. Dana Levine, Clinical Resident for her presentation, “Ronidazole pharmacokinetics in cats after IV administration and oral administration of an immediate release capsule and a colon-targeted delayed release tablet.” [Abstract #148] 2008 ACVIM Forum, San Antonio, Texas. Journal of Veterinary Internal Medicine 22: 745, 2008. First place award also awarded by the AAVPT and ACVCP to Dr. Dana Levine for presentation listed above. Lysa Posner - PI for project where Kristen Messenger (anesthesia resident) was awarded 2nd place in the CVM Research Forum (Pharmacokinetics of Transmucosal Buprenorphine in Horses). Korinn Saker - Summer Fellowship student Adrianna Wilson’s abstract was accepted for oral presentation at the 2008 Nutrition Forum in St. Louis, MO. Expanded abstract is published in peer reviewed journal. Nutrition Intern, Julianne Davis’s abstract was accepted for oral presentation at the AAVN Clinical Nutrition & Research Symposium (in conjunction with ACVIM) in Montreal, CANADA. Barbara Sherry - Jennifer Zurney’s (graduate student) publication in the March 2009 issue of Journal of Virology was selected as one of that issue's "Spotlights", which are "Articles of Significant Interest Selected from This Issue by the Editors" ( for the second time (a previous publication of hers was also selected for this honor). Rachael Thomas - Katie Saylor (CALS, undergraduate research assistant 2007-2008) successfully completed undergraduate honors research project and has graduated cum laude, receiving a BS (Honors) in Biological Sciences with a minor in Genetics. Recruited to a highly regarded pharmaceuticals company with an offer of permanent employment. Research Activities (Description of current/new research directions, development of new tools/reagents and new collaborations): Kenneth Adler - Collaborative endeavors have been set up between my laboratory and numerous other labs throughout the country, including Duke, UNC-CH, NIEHS, EPA, UCLA, University of Pittsburgh, Dartmouth, etc. Prema Arasu - Focus is on zoonotic diseases, food safety and the intersection of health with other disciplines (including agriculture, engineering, environment, communications, community development, etc.). P.I., USDA International Science and Education award, 2008-2012. Total $100,000. "Livestock production practices, biofuels, and environmental and public health: lessons with India". Collaboration with Drs. Vivek Fellner, Ratna Sharma (CALS) and Isabel Gimeno, Maria Correa (PHP). Co P.I., NSF Partners in International Research and Education, 'A Global FoodSafe Initiative', in partnership with Dr. Noel Greis, UNC School of Management/Kenan Institute, to develop a cyber-platform for food safety research, policy, course work. Pre-proposal submitted in January pending score and invitation to submit full proposal in June. Wrote joint proposal with Dr. Lisa Roberts, Head of Microbiology, University of Surrey, U.K. to conduct a joint NCSU/Surrey workshop on zoonotic diseases (funding by University of Surrey). As a result, three NCSU faculty will participate May 21-22, 2009 at Surrey (Gregg Dean, Gerry Luginbuhl/CALS and Prema Arasu). Served as NCSU reviewer for internal review and selection of 3 finalist NCSU pre-proposals for NSF PIRE grants (Partners in International Research and Education). P.I., USAID Higher Education Development proposal " Malawi: Promoting food and environmental security through integrated approaches and innovations in higher education": Co-PIs Daniel Robison, CNR and Rick Brandenburg, CALS. Proposal not funded. P.I. Indo-U.S. Science and Technology Forum proposal "Environment, Society and Development: Approaches to the practice of sustainable development". Co-P.I. Dr. Arabinda Mishra, TERI India. Proposal pending. Jill Barnes - Collaboration with Dr. Paul Orndorff on NIH R21 grant. Matthew Breen - The main focus of the lab is on the molecular cytogenetic evaluation of canine cancers, using the unique demographics of purebred dog populations to identify cancer-associated genes that remain ‘hidden’ in human populations. Have retained an ongoing interest in chromosome evolution, especially as it relates to chromosome changes 13
  14. 14. occurring during speciation that may be associated also with cancer development. This work is ongoing, is funded by several extramural grants and forms the basis of his lab’s research efforts. To embrace new technologies and maintain pace with the rapid developments in these fields, established new collaborations with a variety of leading investigators major US institutions including Duke, MIT, Harvard, John’s Hopkins, Fred Hutchinson Cancer Research Center, University of Minnesota Masonic Cancer Center (and others) to bring new opportunities to the graduate students/post docs etc in the lab and also to provide new avenues for future collaborative funding. Jamie Brown - “Development of Computed Tomography Abdominal Scanning Protocols in the Sedated Canine Patient and Comparison to Abdominal Ultrasound” research grant funded and currently in progress. Submitted grant for ACVR Resident Research Grant “Development of a 3-Dimensional computer-based anatomical atlas of the equine head”. Assisting in Ovarian Tumor model in Chickens (PI: John Barnes). Involvement includes ultrasonographic evaluation of chickens suspected of having ovarian neoplasia as screening tool for MR analysis. Assisting in Hepatic Carcinoma Tumorogenesis model in Woodchucks (PI: John Cullen). Involvement includes ultrasonographic evaluation of woodchucks for tumor screening. Gregg Dean - Continuing to determine the effects of FIV on innate immune function. Developing lactobacillus as a vaccine vector. Developing an IL10-expressing lactobacillus to treat inflammatory bowel disease in cats. Studying the role toll-like receptors on regulatory T cells during HIV infection. Expressing recombinant IL15 to treat FIV infected cats. Depleting regulatory T cells in vivo as an adjunct approach to therapeutic vaccination. Testing a novel mycobacterium tuberculosis vaccine to assess safety for use in captive and wild lions. Collaborating to express feline gamma interferon in a plant system for use to treat feline infectious peritonitis. Collaborating to determine whether environmental modification can reduce stress in shelter cats. Cloning and expressing NC16 to develop a diagnostic test for canine bullous pemphigous. Cloning and expressing NC1 to develop a diagnostic test for canine. Collaborating to develop red clover mosaic virus as a delivery system for chemotherapeutic agents. Collaborating to develop a novel synthetic chlorophyll derivative as an in vivo fluorescence dye. Collaborating to develop a surgical technique for collection of intestinal lymphatic fluid. John Gadsby - Collaboration with Dr. Alan Tonelli in the College of Textiles to synthesize a slow release cyclodextrin complex with prostaglandin (cloprostenol) for use in estrous cycle regulation in swine. Initiated and maintained collaboration with Dr. Martin Sheldon, Royal Veterinary College, London, U.K. to study the ovarian effects of infectious uterine disease and on TLR function in bovine corpus luteum. This resulted from the sabbatical leave in his lab for 6 months (Jan-July 2008), supported by the presitigious Underwood Fellowship to Dr. Gadsby, from the British Biomedical and Biological Research Council (BBSRC), U.K. Initiated collaboration on the effects of uterine infection on bovine embryo function and viability with Dr. Peter Farin, PHP Dept., NCSU College of Veterinary Medicine. Also, through as series of Invited Seminar Presentations, Dr. Gadsby had productive discussions of mutual areas of scientific interest with Dr. Claire Wathes and Dr. Robert Abeysekara at RVC Hawkshead, Dr. Morag Hunter and her research group at University of Nottingham-Sutton Bonington, and with Dr. Rob. Gilbert (Cornell Univ. Vet. College) at the LINK meeting at Swansea University. These discussions at the very least generated a two-way exchange of research ideas and will likely lead to future research interactions and collaborations. A major goal of the Underwood Fellowship was for the Visiting Scientist to plan visits to, and present seminars at, other Universities and Scientific Institutions in the UK (see #3 below) with a view to furthering scientific exchange and developing future research interactions/collaborations. Thus this goal was accomplished with a high degree of success. Troy Ghashghaei - Internal collaborations ongoing: Jon Horowitz and Ken Adler. External Collborations: Kenny Campbell (Cincinnati), Steven Brody (Wash U.), Sally Temple (Albany), Magdalena Gotz (Germany); Roy Sillitoe (Albert Einstein); Glenn Matsushima (UNC) Jon Horowitz - Characterized a conditional "knockout" mouse line and a bevy of transgenic mouse and zebrafish lines that have offered insights into the functions of several gene of interest. Continued a collaboration with Dr. Troy Ghashghaei (MBS Dept.) that utilizes one of our mouse lines to understand the differentiation of neuronal stem cells. Continued a collaboration with Drs. Adam Hawkridge and David Muddiman (NCSU Dept. of Chemistry) to identify early biomarkers of ovarian cancer. Initiated a collaboration with Dr. Carol Trempus (NIH, NIEHS) to help us study skin phenotypes in our transgenic mice. Initiated a collaboration with Dr. David Muddiman (NCSU Dept. of Chemistry) to identify cancer gene-specific markers in vivo via mass spectrometry. 14
  15. 15. Kristina Howard - At present, pursuing two research directions. First, the study of acute mucosal pathogenesis in FIV infection using a new technique (cannulation of the lymphatics) that allows me to assess lymphocytes trafficking from the intestinal mucosa. These studies will better elucidate early events in the mucosa, permit serial sampling and correlation of early responses with the eventual outcome of infection, and may provide new correlates of protection. Second, is the study of AIDS-related lymphoma using the FIV model. Collaborating with Steve Suter (DOCS) and Rachael Thomas (MBS) to identify cellular and molecular markers of progression to lymphoma, in addition to determining what immune populations may provide immunity to lymphomas. Lola Hudson - Continuing testing various cognitive-motor/behavioral tasks with Drs. Sherman and Gruen to determine measureable, significant alterations in FIV-infected cats within a year of infection. Open field testing including habituation and vocalization, and T-maze latencies with weaves and hoops have shown promising initial results. Have also started collaboration with Dr. Ed Breitschwerdt to determine if Bartonella sp can infect cells of CNS origin as his studies have suggested a neurologic component to human patients. Nanette Nascone-Yoder - Current research directions: The role of retinoic acid in digestive organ morphogenesis and evolution; Frog embryo-based chemical genetic screening to identify mechanisms of gut morphogenesis. New Research directions: The role of Wnt/PCP pathway signaling in gut morphogenesis; The role of Pitx2 in left-right asymmetric gut looping and rotation. New tools/reagents: In collaboration with Alex Dieters (NCSU Chemistry), developing photoactivatable reagents (small molecules, morpholinos) for spatial control of gene expression and protein activity within target tissues of living embryos. Shila Nordone - New Collaborations: NCSU-CVM Dr. Jeff Yoder, TMEM150 gene discovery research; NYU Dr. David Levy, HIV Treg latency model development; UNC Dr. David Margolis, Treg Immunopathogenesis in HIV+ patients. Mark Papich - The research laboratory (Clinical Pharmacology Laboratory) has continued to develop new assays and capabilities in 2008-2009. Developed drug assays for several new drugs, in addition to many more that have already been validated. These efforts have led to research projects, successful funding, and several publications (see publication list). One student participated in the summer internship training program (Elizabeth Cranston) and presented her abstract at the annual CVM-Research Forum, 2009. Jorge Piedrahita - Development of transgenic swine that can house human tissues. Identification of PEG3 as a gene affecting human intrauterine growth restriction. Development of the first ever lacZ pig, and the first ever Nk cell deficient pig. Completion of the most comprehensive survey of imprinted genes in swine to date. Manuscript has been submitted for publication. Development of, to his knowledge, the first ever porcine induced pluripotential stem cells (iPS). Korinn Saker - Current project focus: nutritional interventions for breast cancer utilizing the cat as both an animal model for human breast tumors and utilizing and for the species itself as specific breeds of domestic felines have an increased risk for mammary tumor development; cell culture studies with pomegranate fruit extract; development of mammary gland organ culture system to evaluate pomegranate as well as a variety of other potential chemo preventive agents; evaluation of intestinal tight junction proteins in relation to understanding disease mechanisms of IBD and identifying efficacious nutritional intervention protocols for management of the IBD patient . This is a collaborative research effort with pathologists and GI researchers in the CVM. It is a new research area for Dr. Saker; obesity in relation to both oxidative stress and chronic inflammation. This is a collaborative research focus with Dr. Pratt in Animal Science (NCSU). Small animal (mainly feline) obesity research continues with Dr.Terry Swecker (VMRCVM). Philip Sannes - Submitted RO1A2 (renewal) of HL-44497 (priority score: 133; 4.5 percentile). Shift in research direction away from control of epithelial proliferation in the adult lung alveolus toward differentiation. Submitted RO3 in response to RFA on Interstitial Pulmonary Fibrosis (priority score: 146 (no percentiles in RFAs). This is a translational application relating to the involvement of alveolar epithelial differentiation in the development of fibrosis. Continued studies on defining signaling and genetic mechanisms that control the differentiation of epithelial cells in the pulmonary alveolus. Initiated new studies on determining the role of alveolar epithelial differentiation and repair in pulmonary fibrosis. 15
  16. 16. Barbara Sherry - Continued collaboration with ImmunoBiosciences Inc., using their technology to develop a novel vaccine against influenza infection in a mouse model. Continued proteomics efforts in our on-going collaboration with Research Triangle Institute, in our effort to identify novel cardiac responses to viral infection. Cliff Swanson - Initiation of a study using thrompboelastography in examining the mechanism of purported inhibitory affects of acepromazine upon blood clotting. This is a resident research project for Dr. Bobbi Conner, Critical Care Resident. Rachael Thomas - Completion of cytogenetic study of feline sarcomas, identifying potential novel diagnostic biomarkers; development and molecular characterization of a feline injection-site sarcoma cell line; awarded first funding proposal as an established investigator in feline genomics and the application of cytogenetic profiling for molecular classification of feline lymphoma; expansion of departmental, interdepartmental and international collaborations on feline abdominal lymphoma, initiated new collaboration with UC Davis Veterinary School; currently initiating outreach communications with feline rescue centers for education and recruitment of clinical specimens; expansion of laboratory-based studies on canine lymphoma cytogenetics as a model for human lymphoma; continued/published a series of other collaborative canine cancer/genomics studies. Don Thrall - Preparing for the competing renewal of the Hyperthermia Program of Project Grants. In the new submission we will be expanding the studies of canine tumors to include functional imaging of tumor hypoxia and perfusion, and also to noninvasive measurement of tumor temperature. This will necessitate performing imaging and hyperthermia studies at Duke University Medical Center as opposed to here in the CVM. This has been a bureaucratic challenge but progress is being made and we expect to begin this activity over the next few months. This will be critical to remaining completive for funding. Jeff Yoder - New NIH R21: “Whole organism transcriptional profiling of innate immune response” PI: Yoder. June 15, 2008 – May 31, 2010. New Morris Animal Foundation: “Evaluation of TREM-1 as a Specific Biological Marker for Sepsis in Dogs” PI: Nordone (NCSU MBS); co-PI Yoder. Sept., 1, 2008 – Aug. 31, 2011. New CVM grant: “Determining the Barrier Function of the Chorion in the Fish Embryo Test” PI: Law (NCSU-PHP); co-PI: Yoder. July 1, 2008 – June 30, 2009. NIH R01: “Switchable systems for Spatio-Temporal Control of Gene Expression in Zebrafish” PI: Deiters (NCSU Chemistry); co-I: Yoder. Aug 1, 2007- July 31, 2012. New Equipment Supplement to NIH R01: “Switchable systems for Spatio-Temporal Control of Gene Expression in Zebrafish” PI: Deiters (NCSU Chemistry); co-I: Yoder. Summer, 2008. For purchase of MicroPoint(C)® Laser System from Photonic Instruments, Inc. NIH R01: “Novel innate immune receptors in zebrafish” PI: Litman (Univ. South Florida); Sr-I: Yoder. Dec 1, 2006- Nov 30, 2009. CVM grant: “Immune-related, lectin-like receptor 3 (Illr3) and hematopoietic lineages in zebrafish” PI: Yoder. July 1, 2007 – June 30, 2008. CCMTR Pilot Grant: “Defining novel immune response genes as candidate biomarkers for infection” PI: Yoder; co-I Birkenheuer (DoCS); co-I Correa (PHP). July 1, 2007 – June 30, 2008. CCMTR Service Core Grant: “Assessing immune response genes as biomarkers for infection” PI: Yoder. July 1, 2007 – June 30, 2008. CCMTR Innovations Grant: “Upgrade of Compound Microscope Leica DM5000B and PC workstation” PI: Yoder. Awarded Spring 2008. NIH Shared Instrumentation Grant "Nikon AZ100 Macro/Micro Zoom Microscope” PI: Horowitz; co-PIs: Yoder, McGahan, Nascone- Yoder, Sherry, Piedrahita, Rodriguez-Puebla. Publications and Other Professional Activities Please refer to Appendix V (p. 33) for details. MBS faculty contributed the following scholarly works during the past year: 52 Original works in peer-reviewed journals 2 Case reports in peer-reviewed journals 5 Review articles in peer-reviewed journals 1 Books 27 Book chapters, peer-reviewed 80 Abstracts from scientific and professional veterinary conferences 52 citable and 29 not citable 87 Invited presentations (including CE) where the primary audience was professionals 16
  17. 17. 2 Works prepared for presentation and distribution through electronic media, including CD-ROMS, audio and video disks and tapes, computer generated presentations, broadcast videos, etc 3 Continuing education presentations/papers/proceedings where the primary audience was not professionals Professional activities by MBS faculty (Editorial Boards, Ad hoc Manuscript Reviews, Memberships on Research Grant and Study Reviews, Committee Memberships). Please refer to Appendix VI (p. 61) for specific details. 14 Faculty appointed or elected to research study sections 11 Faculty serves as members of editorial boards of journals 24 Faculty served as ad hoc reviewers for journals 15 Faculty served on MBS committees 17 Faculty served on CVM committees 13 Faculty served on NCSU committees 20 Faculty served on other committees Minority Representation and Recruitment Efforts The 33 departmental faculty positions (tenure and non-tenure track) include 9 White females, 19 White males, 1 American Indian female, 2 Hispanic males, 1 Asian female, and 1 Asian male. VI. Students Honors and other measures of quality Professional Degree Program Most activities involving veterinary students will be considered in detail in the annual report from the Office of the Associate Dean of Academic Affairs. A complete list of courses presented and participated in by departmental faculty is given in Appendix III (p. 28). Graduate degree and Residency Programs Departmental faculty actively participate in the NCSU Physiology, Immunology, Toxicology, Biotechnology, Genomic Sciences, Animal Science, and UNC-CH School of Pharmacy graduate degree programs in addition to the CVM’s Comparative Biomedical Sciences (CBS) program. 13 faculty served as major advisors to 37 PhD students and 1 MS student. 18 faculty served on the graduate committees of 59 PhD students and 3 MS students. Minority Representation and Recruitment Efforts Diversity among the graduate students majoring with departmental faculty is shown in the following table: White African-American Hispanic Asian American Indian Totals Male 6 1 0 6 0 13 Female 13 2 1 8 1 25 Totals 19 3 1 14 1 38 17
  18. 18. VII. Research Volume of Activity Extramural and intramural research grants awarded to each departmental faculty member are in listed in Appendix VII (p. 73). Extramural Grant Activity The total for current year awards for MBS PIs on 48 extramural grants in effect this past year was $7,210,828. The following table summarizes the distribution among extramural funding agencies: Agency Source Number Grants Total for Current Direct for Current Year Awards Year Awards US Government 34 6,409,567 4,517,931 Industry 3 118,300 81,500 Foundations 9 538,394 499,364 Trust 0 0 0 Other 2 144,567 144,567 The following table summarizes distribution of the $7,210,828 into departmental research programs. Program Number Grants Total for Current Year Awards Cell biology/respiratory 13 2,093,088 Cell biology/ocular 2 293,129 Gastrointestinal 1 111,632 Oncology/cancer 11 1,660,234 Genomics 7 1,003,446 Infectious Disease 9 1,507,795 Immunology 4 433,860 Other 1 107,644 NIH accounted for 30 of the 34 US government research awards. Of the remaining governmental grants, USDA funded 2, EPA funded 1, and NSF funded 1. Included in these summaries is 1 training grants which total $232,540 in total cost for the current year. The total for current year awards for MBS Co-Is on 20 extramural grants and 3 NCSU grants this past year was $3,111,650. Intramural (CVM) Grant Activity The total dollar amount awarded on 4 intramural grants to MBS faculty serving as PI this past year was $43,668. Specific Achievements of Significance Extramural grant submissions during 2008-2009: MBS PI faculty submitted 36 proposals for extramural grant support in the amount of $32,128,254 (total grant period). 18
  19. 19. The following table summarizes distribution of the grant submissions into departmental research programs. Extramural Program Number Grants Total for Total Grant Period Cell biology/respiratory 3 3,812,500 Gastrointestinal 3 2,170,219 Oncology/cancer 2 4,033,626 Pharmacology 2 31,596 Genomics 2 1,540,317 Infectious Disease 15 12,981,635 Immunology 4 3,318,688 Neurology 2 3,700,000 Nutrition 1 22,181 Other 2 517,492 VIII. Administration and Staff Personnel Department Head, Associate Dean of Research and Director of Research and Graduate Programs, Associate Vice Provost for the Office of International Affairs, Director for the Comparative Medicine and Translational Research Center. A complete list of Administrative and Staff Personnel appears in Appendix II (p. 27). New Faculty Appointments Gabriela Seiler; Associate Professor of Radiology; appointment begins July 1, 2009. Staff: A total of 26 SPA employees and 38 non-faculty EPA employees worked in the department this past year. The overall performance of this staff in supporting the teaching, research and professional service activities of this department is excellent. The staff complement currently stands at 19 with 2 new appointments, 6 resignations and 1 transfer to the Graduate Program. The non-faculty EPA currently stands at 27 with 8 new appointments, and 11 resignations. IX. Recommendations and concerns for the future The Department will continue to pursue updating the curriculum with an emphasis on molecular medicine and in enhancing the Clinician Scientist Focus area with the development of new Selectives. In addition, the Department will continue to encourage efforts in Translational Research, specifically with an increase in emphasis and support (time and resources) of meaningful Scholarly Activity of faculty who have a significant clinical effort. Many MBS faculty members of the department are members of the Center for Comparative Medicine and Translational Research and make contributions to the Center. Our ability to continue to grow extramural research funding continues to be challenging. This is especially with the anticipated loss of two open faculty positions, and SPA staff positions due to cuts in the State budget. However, with the new Administration and the Stimulus package we have an opportunity to obtain significant Federal resources for our faculty. NIH has been given an unprecedented $10.4B from the ARRA funds. Awards will generally be made directly from the NIH institutes. These grants mechanisms include infrastructure upgrades, a multimillion dollar core equipment proposal, individual administrative supplements and bridge grants. Many MBS faculty members are applying for this funding, the full extent of which will not be known until 19
  20. 20. the fall. Fortunately, hospital revenue has not decreased significantly so far this year and is thus a positive factor in the departmental budget and is due to the hard work and dedication of the Clinical faculty. However, despite our past successes, the impact on the Department of continued pressure on both the state and national budget is of grave concern for the future. The effect of these economic pressures may eventually result in less flexibility in supporting research programs, difficulty in raising funds for faculty start-up packages, an inability to provide assistance to faculty for the purchase of equipment, and less available funds to provide technical and teaching support in the Department. It is important that the MBS department continue to maintain a financial “war chest” of at least $250K in order to off-set the negative impact of reductions in the state budget. However this is only a temporary solution, deep cuts in our budget from the state of North Carolina can only be offset for one-two years, then our cash reserves could be used up, and we will have to make alternative budgetary plans in order to bridge productive programs and help them survive through future tough times. X. University’s Five Focus Areas 1. Producing leaders for the state, nation, and world Adler - Numerous leadership positions held by Dr. Adler: chair of numerous study sections, invited speaker at numerous meetings and at different academic, industrial and government institutions. Training of students and postdoctoral fellows to do environmental research via the EPS/NCSU cooperative agreement managed by Dr. Adler. Dr. Adler has received supplements from NIH for minority students working on his R37 grant from HNLBI. Arasu - Working with Park Scholars (Class of 2011) - together with class committee, a learning lab was organized that focused on the “National Debt” with meetings and discussions in Washington D.C. (October 2008). Breen – Dr. Breen’s leading role in the fields of canine and comparative genomics provide members of his lab (permanent and temporary) with good opportunities to become involved in cutting edge research that plays a key role in major international collaborations. Brody - After two years in Dr. Brody’s laboratory, Dr. Keith Salazar accepted a highly competitive position as a staff scientist with the US Environmental Protection Agency. We are very proud that Keith qualified for this research position and moved on to national service. Ghashghaei - Initiated collaborations with a well known group in Germany. Horowitz - Jimmy V/NCSU Cancer Therapeutics Training Program. Nascone-Yoder - Dr. Nascone-Yoder has provided both undergraduate and graduate students with opportunities to perform research in her lab, attend professional conferences, make scientific presentations and network with top scientists. Posner – Dr. Posner is part of the team that trains students, interns and residents as Veterinarians. Veterinarians serve throughout the word; not just healing companion animals but protect our food sources, monitor biosafety as well as contribute to scientific advancement. Furthermore, the training of Veterinary Anesthesia Specialists helps create the next generation of Veterinary Leaders. Sherry – Received the Alumni Distinguished Graduate Professor award for her leadership efforts in helping to develop and lead the university-wide Genomic Sciences graduate program. Continued training 3 graduate students pursuing PhD: Zurney (Microbiology PhD), first-authored publication featured as “Article of Significant Interest”, awarded PhD in December 2008, currently employed as Study Director at Burleson Research Technologies in Morrisville, NC; Li (Functional Genomics PhD), presented research at national meeting (American Society for Virology); Irvin (CBS PhD), served on “Expanding Your Horizons” workshop executive committee (brings 400 seventh-grade girls to NCSU for hands-on science workshops). 20
  21. 21. Yoder - By educating and training Immunology, Comparative Biomedical Sciences and Functional Genomics graduate students (in classes and in his laboratory) Dr. Yoder is contributing to the development of future scientific leaders. 2. Creating educational innovation Arasu - In addition to study abroad experiences, Dr. Arasu has been working on building academic linkages with partners abroad for NCSU community service learning projects. She is also contributing to the development of a new degree program, Master’s in Development Practice. She was also instrumental in the development of an undergraduate offering in public health. Dean - (This program addresses #1 and #2) The Comparative Medicine and Translation Research Training Program is a newly created program that targets individuals trained as veterinarians (have already earned a doctorate in veterinary medicine, DVM) and that have specialty training. This means they have completed a residency in specialty area such as pathology, internal medicine, dermatology, ophthalmology, etc. In this program, individuals will earn a PhD and will focus on the use of animals in research for the purpose of generating knowledge, drugs, therapies or diagnostic techniques that will direct application to veterinary and possibly human patients. The unique combination of training will equip graduates to become leaders in biomedical research. This program is the first of its kind and as such represents an innovative approach to meet the national need for veterinary scientists. Horowitz - Jimmy V/NCSU Cancer Therapeutics Training Program. 3. Improving health and well being Adler - A drug developed from Dr. Adler's research and licensed through the university to a start-up biotechnology company (BioMarck, Raleigh, NC) is now in phase 2a human clinical trials and could become a new treatment for chronic bronchitis in the U.S. and worldwide. Arasu - We will continue efforts initiated in 2008 to provide a public health track and courses to undergraduate students towards a national movement focused on 'The Educated Citizen and Public Health'. We are also beginning a new initiative to create a ‘Health and Wellbeing’ portal for NCSU. The Triangle Global Health Consortium has been formed and is focused on recruiting a Director for fund raising and coordination of institutional efforts. Breen - Research in Dr. Breen’s lab is identifying regions of the canine genome that are associated with response to therapy in cancer patients. Simultaneously, we are translating these canine changes to the human genome and further testing corresponding region of the human genome for their association to prognosis. Dean - The Center for Comparative Medicine and Translational Research (CCMTR) was conceived and implemented by faculty that recognized strong multidisciplinary collaborative teams are necessary to accelerate translational research. Translational research is process of moving laboratory observations into the clinical setting through the creation of new therapeutics, vaccines, diagnostics, and biomedical devises. The Center concept was proposed in 2003, given permission to organize in 2005 and was formally recognized as an official UNC Center by the Board of Trustees in February 2006. The CCMTR has at present over 100 tenure-track faculty representing 16 departments from 5 colleges, with approximately 50% of the participants residing on the Centennial Biomedical Campus. In addition to the traditional biological disciplines found in the Colleges of Veterinary Medicine and Agriculture and Life Sciences, truly multidisciplinary collaborations come through the addition of faculty with expertise in biomedical engineering, biomedical textiles, mathematical modeling, non- traditional statistics, chemical engineering, molecular modeling and more. This brings together faculty that speak different scientific languages but share the desire to bring medical solutions to the clinic. In the short time since it’s inception, the CCMTR has accomplished the following: provided incentives and support to encourage truly multidisciplinary collaborations and accelerate the translation of laboratory research to improved patient 21
  22. 22. care, engaged external academic and corporate advisors to identify research goals and strategies, provided access to sophisticated research equipment. offered facilities and technical assistance to perform clinical trials, awarded seed grant money to launch new ideas and collaborations, hosted workshops and symposia to help faculty remain innovative and knowledgeable, provided educational opportunities for undergraduate and graduate students (including veterinarians) in translational research, developed ties with biomedical researchers at other UNC institutions, created a powerful research enterprise to attract corporate partners to the Centennial Biomedical Campus. Nascone-Yoder – Dr. Nascone-Yoder’s lab conducts federally funded research aimed at understanding the etiology of birth defects. Posner - Veterinarians are major contributors to maintaining the world’s heath through food surveillance and biosafety (bacterial, viral and toxilogical). The training of the next generation of protectors is vital. Sannes - Continues work directed toward understanding the role of alveolar epithelial differentiation in pulmonary fibrosis. Sherry - Continued collaboration with ImmunoBiosciences, Inc. Conducted investigations of ImmunoBiosciences’ vaccine technology for efficacy against influenza infection in a mouse model. Expanded our proteomics efforts in our on-going collaboration with Research Triangle Institute, in our effort to identify novel cardiac responses to viral infection. Received continuation of NIH funding for this research Thrall - We are assessing the biologic effects of tumor hyperthermia in terms of alteration of tumor physiology that may be beneficial, and the optimum manner in which to prescribe hyperthermia. Results of these studies have the potential to refine the use of hyperthermia as a cancer treatment modality in animals and humans. Yoder - The research in Dr. Yoder’s laboratory includes basic functional studies of evolutionarily conserved novel immune response genes. These functional studies will likely form the basis for clinical based studies investigating the roles of these genes in human disease. Ultimately, an understanding of how all genes contribute to the response to and recovery from infection will promote better drug designs for improving human health. 4. Fueling economic development Arasu - Linked with the above mentioned ‘health and wellbeing’ portal for the university, Dr. Arasu will be working with other colleagues/units on campus to improve extension, outreach and economic development related to the health sector at NCSU. Sherry – Dr. Sherry’s graduate student (Jennifer Zurney) was hired by a NC company (Burleson Research Technologies, Inc.), which performs fee-for-service assays. 5. Driving innovation in energy and the environment Arasu - Our USDA International Science and Education award for 2008-2012 bridges sustainable livestock production practices with biofuels and environmental and public health. This is a joint effort between faculty in CVM and CALS; Dr. Arasu is the PI on this award that will also link NCSU with regional stakeholders and our partners in India. 22
  23. 23. Appendix I List of Faculty/EPA Employees Including Graduate Students FACULTY Kenneth Adler, PhD Professor; Cell Biology, Physiology, Environmental Science & Toxicology Prema Arasu, DVM Professor; Infectious Disease; Assoc Vice Provost, Office of International Affairs; Director, Global Health Initiatives; Director, CVM International Programs; promotion to Professor 7/1/08; promotion to Assoc Vice Provost 7/1/08 Makoto Asakawa, BVSc Clinical Assistant Professor; Anesthesiology Jill Barnes, PhD Teaching Associate Professor; Cell Biology & Anatomy Matthew Breen, PhD Professor; Cell Biology, Physiology, & Genomics Arnold Brody, PhD Research Professor; Respiratory Biology James Brown, DVM Clinical Assistant Professor, Radiology Nigel Campbell, PhD Clinical Assistant Professor; Anesthesiology Gregg Dean, DVM Professor; Infectious Disease; Director, Center for Comparative Medicine and Translational Research; promotion to Professor 7/1/08 Professor of Physiology, Associate Dean of Research and Director of Research and Graduate Programs Professor of Physiology, Associate Dean of Research and Director of Research and Graduate Programs James Douglass, DVM Clinical Assistant Professor; Radiology Lloyd Fleisher, PhD Professor; Pharmacology John Gadsby, PhD Professor; Cell Biology, Physiology, Reproductive Biology Troy Ghashghaei, PhD Assistant Professor; Developmental Neurobiology, Adult Neurogenesis, Gene Therapy Jonathan Horowitz, PhD Associate Professor; Cancer Biology, & Cell Biology Kristina Howard, DVM Research Assistant Professor; Infectious Disease Lola Hudson, DVM, PhD Professor; Cell Biology & Anatomy; promotion to Professor 7/1/08 Linda Martin, PhD Assistant Professor; Cell Biology, Physiology, Environmental Science & Toxicology; resigned 7/1/08 M. Christine McGahan, PhD Professor & Department Head; Cell Biology, Pharmacology, Environmental Science & Toxicology Nanette Nascone-Yoder, PhD Assistant Professor; Developmental Biology Shila Nordone, PhD Research Assistant Professor Mark Papich, DVM Professor; Clinical Pharmacology Anthony Pease, DVM Assistant Professor; Anesthesiology; resigned 9/2/08 Jorge Piedrahita, PhD Professor; Genomic & Reproductive Biology Lysa Posner, DVM Clinical Associate Professor; Anesthesiology; promotion to Clinical Associate Professor 7/1/08 Doodipala S. Reddy, PhD Assistant Professor; Neuroscience & Pharmacology; resigned 7/1/08 Ian Robertson, BVSc Clinical Associate Professor; Radiology Marcelo Rodriguez-Puebla, PhD Associate Professor; Cancer Biology, Cell Biology, & Physiology Korinn Saker, PhD, DVM Associate Professor; Clinical Nutrition Philip Sannes, PhD Professor; Cell Biology, Physiology, Environmental Science & Toxicology Barbara Sherry, PhD Professor; Infectious Disease; Director, Genomic Sciences Graduate Program James E. Smallwood, DVM Professor; Anatomy Clifford Swanson, DVM Associate Professor; Anesthesiology Rachael Thomas, FD Research Assistant Professor Donald Thrall, DVM, PhD Professor; Radiology & Cancer Biology Jeffrey Yoder, Ph.D. Assistant Professor; Immunology 23
  24. 24. EMERITUS PROFESSORS Robert A. Argenzio, PhD Professor Emeritus Arthur L. Aronson, DVM, PhD Professor Emeritus Peter J. Bentley, PhD Named Professor Emeritus Cecil Brownie, DVM, PhD Professor Emeritus Terrence M. Curtin, DVM, PhD Professor Emeritus Charles E. Stevens, DVM, PhD Professor Emeritus EPA PROFESSIONALS Dieldrich Bermudez, PhD Post Doc Research Associate (Adler) Chad Blystone,PhD Post Doc Research Assoc (Adler); resigned 5/1/08 Katherine Bortoff, PhD Research Associate (Sannes); appointed 8/1/08 Seema Briyal, PhD Research Assoc (Reddy); resigned 7/1/08 Kathryn Byler, BS Research Asst (Breen) Beth Case, BS Research Asst (Thrall) Anne Crews, MS Laboratory Supervisor (Adler) Demetrio Dichoso, BS Laboratory Supervisor (Piedrahita) Michael Dush, PhD Research Assoc (Nascone-Yoder) Shijing Fang, MD Research Asst (Adler) Laila Farzana, MS, PhD Post Doc Research Assoc (Yoder); appointed 2/1/09 Omkaram Gangisetty, MS, PhD Post Doc Research Assoc (Reddy); resigned 7/1/08 Jillian Gee, PhD Post Doc Research Assoc (Adler); resigned7/4/08 Margaret Goralska, PhD Research Assoc(McGahan) Alexandra Hamilton, BS Research Asst (Breen) Benoit Hedan, DVM, PhD Post Doc Research Associate (Breen) Andrew Hotchiss, PhD Post Doc Research Assoc (Adler); resigned 6/21/08 Lisa Jesse, DVM Lecturer (McGahan); appointed 7/1/08 Apparao Kummarapurugu, PhD Research Assoc (Sannes); resigned 4/5/08 Susan Lankford, PhD Research Assoc (Brody) Julie Long, BS Research Assistant (Dean); appointed 7/21/08 Jeffrey Miller, PhD Post Doc Research Associate (Brody); appointed 8/18/08 Steven Nagar, PhD Research Assoc( McGahan) Donna Newman, PhD Research Assoc (Sannes) Joungjoa Park, MS Research Assoc (Adler) Cynthia Rider, PhD Post Doc Research Assoc (Adler); resigned 12/12/08 Keith Salazar, PhD Post Doc Research Assoc (Brody); resigned 7/4/08 Raul Salinas-Mondragon, FM, PhD Research Asst (Ghashghaei ) Amy Tanner, DVM Research Asst (Saker); resigned 8/2/08 Nicole Tinfo, PhD Post Doc Research Assoc (Adler) Poem Turner, BS Research Associate (Yoder); appointed 8/18/08 Jenora Waterman, PhD Post Doc Research Assoc (Adler); resigned 10/1/08 Christina Williams, BS Research Asst (Breen) Alice Wright, BS Research Asst (Piedrahita); resigned 9/1/08 Tiffany Yelverton, MS, PhD Post Doc Research Associate (Adler); appointed 9/22/08 Qi Yin, PhD Post Doc Research Assoc (Brody) 24
  25. 25. Lin Zhang, FM, MS Research Assistant (Dean); appointed 6/23/08 Leah Zorilla, PhD Post Doc Research Assoc (Adler) RESIDENT PROGRAM Jerome Benoit, VMD Resident in Radiation Oncology (Thrall); completed 7/1/09 Jennifer Carter, DVM Resident in Anesthesiology (Posner); completed 9/30/09 Christina Copple, DVM Resident in Radiology (Robertson); appointed 7/1/08 Julianne Davis, MS, DVM Resident in Nutrition (Saker); appointed 7/1/08 Erica Fields, VMD Resident in Radiology (Robertson) Lisa Jesse, DVM Resident in Radiology (Pease); completed 7/1/08 William Lee, DVM Resident in Radiology (Robertson); completed 7/1/09 Kristen Messenger, VMD Resident in Anesthesiology (Posner) James Montgomery, DVM Resident in Radiology (Robertson); appointed 7/1/08 Kerensa Rechner, DVM Resident in Radiation Oncology (Thrall); appointed 7/1/08 Keijiro Shiomitsu, BVS Resident in Radiation Oncology (Thrall); completed 8/1/08 Sarena Sunico, DVM Resident in Radiology (Robertson) ADJUNCT FACULTY Vikram Arora, PhD Adjunct Assistant Professor (Talecris Biotherapeutics) Stephanie Berry, MS, DVM Adjunct Assistant Professor (VA Tech) Stacy Branch, DVM, PhD Associate D.A.B.F.M. (NCSU; Environmental & Molecular Toxicology) Richard Broadstone Adjunct Professor (IAMS); appointed 12/1/08 Fidel O. Castro, MAGRI, PhD Adjunct Associate Professor (University of Concepcion, Chile; University of Havana, Cuba) Carmen Colitz, DVM, PhD Adjunct Associate Professor (Animal Eye Specialty Clinic, West Palm Beach, FL) Ralph Cooper, PhD Adjunct Professor (EPA) Sally Perreault Darney, PhD Adjunctor Professor (EPA) Mark W. Dewhirst, DVM, PhD Adjunct Professor (Duke University Medical Center) Darlene Dixon, DVM, PhD Adjunct Associate Professor (NIEHS) Kevin L. Dreher, PhD Adjunct Professor (EPA) Thomas E. Eling, PhD Adjunct Associate Professor (NIEHS) Bernard Fischer, DVM, PhD Adjunct Instructor (Duke University Medical Center) Dori R. Germolec, PhD Adjunct Associate Professor (NIEHS) Gerald Huntington, PhD Associate Member (NCSU; Animal Science) Donna Matthews Jarrell, DVM Adjunct Associate Professor (Massachusetts General Animal Hospital) Gary J. Jesmok, PhD Adjunct Professor (Bayer Corporation) Hillel Koren, PhD Adjunct Professor (EPA) Christopher S. Lau, PhD Adjunct Professor (EPA) Rick Meeker, PhD Adjunct Professor (UNC Chapel Hill) Indu Parikh, PhD Adjunct Professor (Biomarck Pharmaceuticals) James A. Raleigh, PhD Adjunct Professor (UNC School of Medicine) Peifeng Ren, PhD Adjunct Assistant Professor (BASF Plant Science LLC) John Rogers, PhD Adjunct Professor (EPA) David A. Schwartz, MD Adjunct Professor (NIEHS) Gregory Sempowski, PhD Adjunct Assistant Professor (Duke Univ) Robert Smart, PhD Associate Member (NCSU; Environmental & Molecular Toxicology) Jerry Wayne Spoo, DVM Adjunct Assistant Professor (RJ Reynolds) William Stokes, DVM Adjunct Professor (NIEHS) Robert Voyksner, PhD Adjunct Associate Professor (LCMS Limited) Xiangdong Wang, MD, PhD Adjunct Professor (AstraZeneca R&D Lund, Sweden) 25