A. Postions and Honors..doc

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A. Postions and Honors..doc

  1. 1. Principal Investigator/Program Director (Last, First, Middle): Johnson, Rodney Wayne BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Rodney W. Johnson Professor of Integrative Immunology and Behavior eRA COMMONS USER NAME rwjohn EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Truman State University, Kirksville, MO B.S. 1986 Animal Sciences University of Illinois, Urbana-Champaign, IL M.S. 1989 Environmental Physiology University of Illinois, Urbana-Champaign, IL Ph.D. 1992 Immunophysiology Iowa State University, Ames, IA (postdoctorate) 1992-1993 Immunophysiology A. Postions and Honors. Employment 1987-1989 Graduate Research Assistant, Environmental Physiology, Dept. of Animal Sciences, University of Illinois, Urbana 1989-1992 Graduate Research Assistant, Immunophysiology, Dept. of Animal Sciences, University of Illinois, Urbana 1992-1993 Postdoctoral Fellow, Dept. of Animal Science, Iowa State University 1993.1998 Assistant Professor of Integrative Biology, Dept. of Animal Sciences, University of Illinois, Urbana 1998-2003 Associate Professor of Integrative Biology, Dept. of Animal Sciences, University of Illinois, Urbana 2003-present Professor of Integrative Biology, Dept. of Animal Sciences, University of Illinois, Urbana Selected Professional Honors and Recognition 1. NPPC Innovation Award - Basic Research Category, 1993, 1996, 2001, and 2002 2. Appointed Fellow in the Center for Advanced Study, University of Illinois, Urbana, 1997-1998 3. International Life Sciences Institute Future Leader Award, 1998 4. Midwest American Society of Animal Science Outstanding Young Animal Scientist Award, 1999 5. H. H. Mitchell Award for Excellence in Graduate Teaching and Research, Dept. of Animal Sciences, University of Illinois, 1999 6. Bio-Serv Award, American Society for Nutritional Sciences, 2001 7. Editor of the Environment and Behavior section of the Journal of Animal Science, 1999-2002 9. Editorial Board, Brain, Behavior & Immunity, 2003-present 10. Animal Growth and Development Award, American Society of Animal Science, 2002 11. University Scholar, University of Illinois, 2003 12. Neuroendocrinology, Neuroimmunology, and Behavior Study Section, NIH, Temporary Member, 2004-2005. 13. Neuroendocrinology, Neuroimmunology, and Behavior Study Section, NIH, Member, 2005-2009. 14. Psychoneuroimmunology Research Society Council (2005-2008) 15. Science Foundation Ireland, Program Progress Assessment Panel, Institute of Neuroscience, Trinity College, Dublin, Ireland, 2008. B. Refereed Publications 1. Johnson, R. W., S. E. Curtis, and R. D. Shanks. 1991. Effects on chick performance of ammonia and heat stressors in various combination-sequences. Poultry Sci. 70:1132-1137. 2. Johnson, R. W., S. E. Curtis, R. Dantzer and K. W. Kelley. 1993. Central and peripheral prostaglandins are involved in sickness behavior in the chicken. Physiol. Behav. 53:127-131. 3. Johnson, R. W., S. E. Curtis, R. Dantzer, J. M. Bahr, and K. W. Kelley. 1993. Sickness behavior in birds caused by peripheral or central injection of endotoxin. Physiol. Behav. 53:343-348. 4. Johnson, R. W. and E. von Borell. 1994. Lipopolysaccharide-induced sickness behavior in pigs is inhibited by pretreatment with indomethacin. J. Anim. Sci. 72:309-314. 5. Johnson, R. W., E. von Borell, L. L. Anderson, L. D. Kojic, and J. E. Cunnick. 1994. Intracerebroventricular injection of corticotropin-releasing hormone in the pig: acute effects on behavior, adrenocorticotropin secretion, and immune suppression. Endocrinology 135:642-648. 6. Kelley, K. W., R. W. Johnson, and R. Dantzer. 1994. Immunology discovers physiology. Vet. Immunol. Immunopathol. 43:157-165. 7. Johnson, R. W., M. J. Propes, and Y. Shavit. 1996. Corticosterone modulates the behavioral and metabolic effects of lipopolysaccharide. Am. J. Physiol. 270:R192-R198. 8. Propes, M. J. and R. W. Johnson. 1997. Role of corticosterone in the behavioral effects of central interleukin-1β. Physiol. Behav. 61:7-13. 9. Johnson, R. W., S. Arkins, R. Dantzer, and K. W. Kelley. 1997. Hormones, lymphohemopoietic cytokines and the neuroimmune axis. Comp. Biochem. Physiol. 116:183-201. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 7 Biographical Sketch Format Page
  2. 2. Principal Investigator/Program Director (Last, First, Middle): Johnson, Rodney Wayne 10. Finck, B. N., R. Dantzer, K. W. Kelley, J. Woods, and R. W. Johnson. 1997. Central lipopolysaccharide elevates plasma interleukin-6 concentration by an α-adrenoreceptor-mediated mechanism. Am. J. Physiol. 272:R1880-R1887. 11. Johnson, R. W. 1997. Inhibition of growth by pro-inflammatory cytokines: an integrated view. J. Anim. Sci. 75:1244-1255. 12. Johnson, R. W., G. Gheusi, S. Segreti, R. Dantzer, and K. W. Kelley. 1997. C3H/HeJ mice are refractory to lipopolysaccharide in the brain. Brain Res. 752:219-226. 13. Warren, E. J., B. N. Finck, S. Arkins, K. W. Kelley, R. W. Scamurra, M. P. Murtaugh, and R. W. Johnson. 1997. Coincidental changes in behavior and plasma cortisol in unrestrained pigs following intracerebroventricular injection of tumor necrosis factor-α. Endocrinology 138:2365-2371. 14. Webel, D. M., B. N. Finck, D. H. Baker, and R. W. Johnson. 1997. Time course of elevated plasma cytokines, cortisol and urea- nitrogen in pigs following intraperitoneal injection of lipopolysaccharide. J. Anim. Sci. 75:1514-1520. 15. Segreti, J., G. Gheusi, R. Dantzer, K. W. Kelley, and R. W. Johnson. 1997. Defect in interleukin-1β secretion prevents sickness behavior in C3H/HeJ mice. Physiol. Behav. 61:873-878. 16. Finck, B. N. and R. W. Johnson. 1997. Anorexia, weight loss, and increased plasma interleukin-6 induced by chronic intracerebroventricular infusion of interleukin-1β in the rat. Brain Res. 761:333-337. 17. Yao, J. and R. W. Johnson. 1997. Induction of interleukin-1β converting enzyme (ICE) in murine microglia by lipopolysaccharide. Mol. Brain Res. 51:170-178. 18. Hyun, Y., M. Ellis, G. Riskowski, and R. W. Johnson. 1998. Growth performance of pigs subjected to multiple concurrent environmental stressors. J. Anim. Sci. 76:721-727. 19. Finck, B. N., K. W. Kelley, R. Dantzer, and R. W. Johnson. 1998. In vivo and in vitro evidence for the involvement of tumor necrosis factor-α in the induction of leptin by lipopolysaccharide. Endocrinology 139:2278-2283. 20. Burgess, W., G. Gheusi, J. Yao, R. W. Johnson, R. Dantzer, and K. W. Kelley. 1998. Interleukin-1β converting enzyme deficient mice resist central but not systemic endotoxin-induced aphagia. Am. J. Physiol. 274:R1829-R1833. 21. Johnson, R. W. 1998. Immune and endocrine regulation of food intake in sick animals. Dom. Anim. Endocrinol. 15:309-318. 22. R. L Matteri, Klir, J. J., B. N. Finck, and R. W. Johnson. 1998. Neuroendocrine-immune interactions in the neonate. Dom. Anim. Endocrinol. 15:397-407. 23. Webel, D. M., D. C. Mahan, R. W. Johnson, and D. H. Baker. 1998. Pretreatment of young pigs with vitamin E attenuates the elevation in plasma interleukin-6 and cortisol caused by a challenge dose of lipopolysaccharide. J. Nutr. 128:1657-1660. 24. Webel, D. M., R. W. Johnson, and D. H. Baker. 1998. Lipopolysaccharide-induced reductions in food intake do not decrease the efficiency of lysine and threonine utilization for protein accretion in chickens. J. Nutr. 128:1760-1766. 25. Hyun, Y., M. Ellis, and R. W. Johnson. 1998. Effects of feeder type, space allowance and mixing on the growth performance and feed intake pattern of growing pigs. J. Anim. Sci. 76:2771-2778. 26. Webel, D. M., R. W. Johnson, and D. H. Baker. 1998. Lipopolysaccharide-induced reductions in body weight gain and feed intake do not reduce the efficiency of arginine utilization for whole-body protein accretion in chicks. Poultry Sci. 77:1893-1898. 27. Ye, S. and R. W. Johnson. 1999. Increased interleukin-6 expression by microglia from brain of aged mice. J. Neuroimmunol. 93:139-148. 28. Dantzer, R., G. Gheusi, R. W. Johnson, and K. W. Kelley. 1999. Central administration of insulin-like growth factor-I inhibits lipopolysaccharide-induced sickness behavior in mice. NeuroReport 10:289-292. 29. Finck, B. N. and R. W. Johnson. 1999. Lipopolysaccharide in the brain increases circulating leptin levels. NeuroReport 10:153:156. 30. Nelson, K. P., N. L. Marks, J. R. R. Heyen, and R. W. Johnson. 1999. Behavior of adult and aged mice before and after central injection of interleukin-1β. Physiol. Behav. 66:673-679. 31. Baker, D. H. and R. W. Johnson. 1999. Disease stress, cytokines and amino acid needs of pigs. Pig News Info. 20:123-124. 32. Yao, J.-H., S.-M. Ye, W. Burgess, J. F. Zachary, K. W. Kelley, and R. W. Johnson. 1999. Mice deficient in interleukin-1β converting enzyme resist anorexia induced by central lipopolysaccharide. Am. J. Physiol. 277:R1435-R1443. 33. Finck, B. N. and R. W. Johnson. 2000. Tumor necrosis factor (TNF)-α induces leptin secretion through the p55 TNF receptor. Am. J. Physiol. 278:R537-R543. 34. Heyen, J. R. R., S. M. Ye, B. N. Finck, and R. W. Johnson. 2000. Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-κB. Mol. Brain Res. 77:138-147. 35. Finck, B. N. and R. W. Johnson. 2000. Regulation of leptin production by the lipostatic cytokine, tumor necrosis factor-α. Microscopy Res. Tech. 50:209-215. 36. Ye, S. M. and R. W. Johnson. 2001. Regulation of interleukin-6 gene expression in brain of aged mice by nuclear factor κ B. J. Neuroimmunol. 117:87-96. 37. Venters, H. D., S. R. Broussard, J. H. Zhou, R. M. Bluthe, G. G. Freund, R. W. Johnson, R. Dantzer, and K. W. Kelley. 2001. Tumor necrosis factor α and insulin-like growth factor-I in the brain: Is the whole greater than the sum of its parts? J. Neuroimmunol. 119:151-165. 38. Zhou, J. H., S. R. Broussard, K. Strle, G. G. Freund, R. W. Johnson, R. Dantzer and K. W. Kelley. 2001. IL-10 inhibits apoptosis of promyeloid cells by activating insulin-receptor substrate-2 and phosphatidylinositol 3’-kinase. J. Immunol. 167:4436-4442. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 8 Biographical Sketch Format Page
  3. 3. Principal Investigator/Program Director (Last, First, Middle): Johnson, Rodney Wayne 39. Broussard, S., J. H. Zhou, H. D. Venters, R. M. Bluthé, R. W. Johnson, R. Dantzer, and K. W. Kelley. 2001. At the interface of environment-immune interactions: cytokines and growth factor receptors. J. Anim. Sci. 79:E268-E284. 40. Johnson, R. W. and B. N. Finck. 2001. Tumor necrosis factor α and leptin: two players in animals’ metabolic and immunologic responses to infection. J. Anim. Sci. 79(E. Suppl.):E118-E127. 41. Ye, S. M. and R. W. Johnson. 2001. An age-related decline in interleukin (IL)-10 may contribute to the increased expression of IL-6 in brain of aged mice. Neuroimmunomodulation 9:183-192. 42. Strle, K., J. H. Zhou, S. R. Broussard, R. W. Johnson, G. G. Freund, R. Dantzer and K. W. Kelley. 2001. IL-10 in the brain. Crit. Rev. Immunol. 21:427-449 43. Strle, K., J. H. Zhou, S. R. Broussard, H. D. Venters, R. W. Johnson, G. G. Freund, R. Dantzer, and K. W. Kelley. 2002. Interleukin-10 promotes survival of microglia without activating AKT. J. Neuroimmunol. 122:9-19. 44. Escobar, J., W. G. Van Alstine, D. H. Baker, and R. W. Johnson. 2002. Growth performance and whole-body composition of pigs experimentally infected with Mycoplasma hyopneumoniae. J. Anim. Sci. 80:384-391. 45. Finck, B. N. and R. W. Johnson. 2002. Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-α. Am. J. Physiol. 282:R1429-R1435. 46. Johnson, R. W. 2002. The concept of sickness behavior: A brief chronological account of four key discoveries. Vet. Immunol. Immunopath. 87:443-450. 47. Kelley, K. W., R. M. Bluthé, R. Dantzer, J. H. Zhou, W. H. Shen, R. W. Johnson, and S. R. Broussard. 2003. Cytokine-induced sickness behavior. Brain Behav. Immun. 117:S112-S118. 48. Broussard, S. R., R. H. McCusker, J. E. Novakofski, K. Strle, W. H. Shen, R. W. Johnson, G. G. Freund, R. Dantzer, and K. W. Kelley. 2003. Cytokine-hormone interactions: tumor necrosis factor impairs biologic activity and downstream activation signals of the IGF-I receptor in myoblasts. Endocrinology 144:2988-2996. 49. Godbout, J. P. and R. W. Johnson. 2004. Interleukin-6 in the aging brain. J. Neuroimmunol. 147:141-144. 50. Berg, B. M. J. P. Godbout, K. W. Kelley, and R. W. Johnson, 2004. α-tocopherol attenuates lipopolysaccharide-induced sickness behavior in mice. Brain Behav. Immun. 18:149-157. 51. Godbout, J. P., B. M. Berg, K. W. Kelley, and R. W. Johnson. 2004. α-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain. J. Neuroimmunol. 149:101-109. 52. Broussard, S. R., R. H. McCusker, J. E. Novakofski, K. Strle, W. H. Shen, R. W. Johnson, R. Dantzer, and K. W. Kelley. 2004. Interleukin-1β impairs IGF-I-induced differentiation and downstream activation signals of the IGF-I receptor in myoblasts. J. Immunol. 172:7713-7720. 53. Shen, W. H., S. T. Jackson, S. R. Broussard, R. H. M cCusker, K. Strle, G. G. Freund, R. W. Johnson, R. Dantzer and K. W. Kelley. 2004. Interleukin-1β suppresses prolonged Akt activation and expression of E2F-1 and cyclin A in breast cancer cells. J. Immunol. 172:7272-7281. 54. Shen, W. H., J. H. Zhou, S. R. Broussard, R. W. Johnson, R. Dantzer, and K. W. Kelley. 2004. Tumor necrosis factor α inhibits insulin-like growth factor-I-Induced hematopoietic cell survival and proliferation. Endocrinology 145:3101-3105. 55. Toepfer-Berg, T. L., J. Escobar, W. G. Van Alstine, D. H. Baker, J. L. Salak-Johnson, and R. W. Johnson. 2004. Vitamin E supplementation does not mitigate the acute morbidity effects of porcine reproductive and respiratory syndrome virus in nursery pigs. J. Anim. Sci. 82:1942-1951. 56. Strle, K., S. R. Broussard, R. H. McCusker, W. H. Shen, R. W. Johnson, G. G. Freund, R. Dantzer and K. W. Kelley. 2004. Proinflammatory cytokine impairment of IGF-I-induced protein synthesis in skeletal muscle myoblasts requires ceramide. Endocrinology 145:4592-4602. 57. Chen, J. and R. W. Johnson. 2004. Dehydroepiandrosterone-sulfate did not mitigate sickness behavior in mice. Physiol. Behav. 82:713-719. 58. Escobar, E., W. G. Van Alstine, D. H. Baker, and R. W. Johnson. 2004. Decreased protein accretion in pigs with viral and bacterial pneumonia is associated with increased myostatin expression in muscle. J. Nutr. 134:3047-3053. 59. Johnson, R. W. and J. Escobar. 2005. Immune system: nutrition effects. In: Encyclopedia of An. Sci., Eds. Wilson Pond and Alan Bell, Marcel Dekker, Inc. pg 541-543. 60. Hyun, Y., M. Ellis, S. E. Curtis, and R. W. Johnson. 2005. Environmental temperature, space allowance, and regrouping: Additive effects of multiple concurrent stressors in growing pigs. J. Swine Health Prod. 13:131-138. 61. Berg, B. M., J. P. Godbout, J. Chen, K. W. Kelley, and R. W. Johnson. 2005. α-Tochopherol and selenium facilitate recovery from lipopolysaccharide-induced sickness in aged mice. J. Nutr. 135:1157-1163. 62. Godbout, J. P., J. Chen, J. Abraham, A. F. Richwine, B. M. Berg, K. W. Kelley, and R. W. Johnson. 2005. Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J. 19:1329-1331. 63. Richwine, A. F., J. P. Godbout, B. M. Berg, J. Chen, J. Escobar, D. K. Millard, and R. W. Johnson. 2005. Improved psychomotor performance in aged mice fed diet high in antioxidants is associated with reduced ex vivo interleukin-6 production. Brain Behav. Immun. 19:512-520. 64. Godbout, J. P., B. M. Berg, C. Krzyszton, and R. W. Johnson. 2005. α-Tocopherol attenuates NFκB activation and pro- inflammatory cytokine production in brain and improves recovery from lipopolysaccharide-induced sickness behavior. J. Neuroimmunol. 169:97-205. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 9 Biographical Sketch Format Page
  4. 4. Principal Investigator/Program Director (Last, First, Middle): Johnson, Rodney Wayne 65. O’Connor, J.C, Satpathy, A, Hartman, M.E., Horvath, E.M., Kelley, K.W., Dantzer, R., Johnson, R.W., Freund, G.G. 2005. IL-1β- mediated innate immunity is amplified in the db/db mouse model of type 2 diabetes. J. Immunol. 174:4991-4997 66. Escobar, J., T. L. Toepfer-Berg, J. Chen, W. G. Van Alstine, J. M. Campbell and R. W. Johnson. 2006. Supplementing drinking water with Solutein did not mitigate acute morbidity effects of PRRSV in nursery pigs. J. Anim. Sci. 84:2101-2109. 67. Selvaraj, V., D. Bunick, R. W. Johnson, L. Liu, and P. S. Cooke. 2005. Gene expression profiling of 17β-estradiol and genistein effects on mouse thymus. Toxicological Sci. 87:97-112. 68. Strle, K., S. R. Broussard, R. H. McCusker, W. H. Shen, J. M. LeCleir, R. W. Johnson, G. G. Freund, R. Dantzer, and K. W. Kelley. 2006. C-jun N-terminal kinase mediates TNFα suppression of differentiation in myoblasts. Endocrinology 147:4363-4373. 69. Sparkman, N. L., J. B. Buchanan, J. R. R. Heyen, J. Chen, J. L. Beverly, and R. W. Johnson. 2006. Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers. J. Neurosci. 26:10709-10716. 70. McCusker, R. H., K McCrea, S. Zunich, R. Dantzer, S. R. Broussard, R. W. Johnson, and K. W. Kelley. 2006. Insulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neurons. J. Neuroimmunol. 179:186-190. 71. Gaykema, R. P. A., M. K. Balachandran, J. P. Godbout, R. W. Johnson, and L. E. Goehler. 2007. Enhanced neuronal activation in central autonomic network nuclei in aged mice following acute peripheral immune challenge. Autonom. Neurosci.131:137-142. 72. Sutherland, M. A., S. R. Niekamp, R. W. Johnson, W. G. Van Alstine, and J. L. Salak-Johnson. 2007. Heat and social rank impact behavior and physiology of PRRS-virus-infected pigs. Physiol. Behav. 90:73-81. 73. Abraham, J., S. Jang, J. P. Godbout, J. Chen, K. W. Kelley, R. Dantzer, and R. W. Johnson. 2006. Aged mice are more sensitive to behavioral deficits induced by centrally administered HIV-1 gp120. Neurobiol. Aging (currently available as Epub) 74. Escobar, J., W. G. Van Alstine, D. H. Baker, and R. W. Johnson. 2007. Behavior of pigs with viral and bacterial pneumonia. J. Appl. Anim. Behav. Sci. 105:42-50. 75. Strle, K., R. H. McCusker, L. Tran, A. King, R. W. Johnson, G. G. Freund, R. Dantzer, and K. W. Kelley. 2007. Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFα-induced resistance to IGF-I in myoblasts. J. Neuroimmunol. 188:48-55. 76. Buchanan, J. B. and R. W. Johnson. 2007. Regulation of food intake by inflammatory cytokines in the brain. J. Neuroendocrinol. 86:183-190. 77. Dantzer, R., J. C. O’Connor, G. G. Freund, R. W. Johnson, and K. W. Kelley. 2008. From inflammation to sickness and depression: When the immune system subjugates the brain. Nature Rev. Neurosci. 9:46-56. 78. Chen, J., J. B. Buchanan, N. L. Sparkman, J. P. Godbout, G. G. Freund, and R. W. Johnson. 2008. Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system. Brain Behav. Immun.22:301-311. 79. Huang, Y., C. J. Henry, R. Dantzer, R. W. Johnson, and J. P. Godbout. 2008. Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide. Neurobiol. Aging (In Press). 80. Godbout, J. P., M. Moreau, J. Lestage, J. Chen, N. L. Sparkman, N. Castanon, K. W. Kelley, R. Dantzer, and R. W. Johnson. 2008. Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system. Neuropsychopharmacology (In Press). 81. O'Connor, J.C., R.H. McCusker, K. Strle, R.W. Johnson, R. Dantzer and K.W. Kelley. 2008. Regulation of IGF-I function by proinflammatory cytokines: At the interface of immunology and endocrinology. Cellular Immunology (In Press) 82. Meador, B., C. Krzyszton, R. W. Johnson, and K. Huey. 2008. Effects of IL-10 and age on IL-6, IL-1β, and TNFα: Responses in mouse skeletal and cardiac muscle to an acute inflammatory insult. J. Appl. Physiol. (In Press). 83. Buchanan, J. B., N. L. Sparkman, J. Chen, and R. W. Johnson. 2008. Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice. Psychoneuroendocrinology (In Press). 84. Jang, S. K. W. Kelley, and R. W. Johnson. 2008. Luteolin reduces interleukin-6 production in microglia by inhibiting c-Jun N- terminal kinase phosphorylation and activation of AP-1. Proc. Natl. Acad. Sci. (In Press). 85. Dilger, R. N. and R. W. Johnson. (accepted pending minor revision) Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J. Leukocyte Biol. 86. Richwine, A. F., A. O. Parkin, J. B. Buchanan, J. Chen, J. A. Markham, J. M. Juraska, and R. W. Johnson. (submitted) CA1 pyramidal neurons of aged, but not young adult, mice retract dendritic branches in response to peripheral immune stimulation. 87. Strle, K., R. McCusker, S. Zunich, R. W. Johnson, R. Dantzer, and K. W. Kelley. (submitted) The prototypical anti-inflammatory cytokine, IL-10, acts to reverse IGF-I resistance in myoblasts. 88. Weber, R. J., R. Gomez-Flores, J. E. Smith, R. W. Johnson, J. Escobar, and T. J. Martin. (submitted) Alterations of neuroendocrine and immune functions and presence of plasma endotoxin and TNFα indicates a cachectic state in rats made physically dependent to heroin 89. Strle, K., R. McCusker, R. W. Johnson, S. Zunich, R. Dantzer, and K. W. Kelley. (submitted) The prototypical anti-inflammatory cytokine, IL-10, prevents loss of IGF-I-induced myogenin protein expression caused by IL-1β. 90. O’Connor, J. C., R. H. McCusker, R. W. Johnson, R. Dantzer, and K. W. Kelley. (submitted) Antibiotics, inflammation and animal growth: Cytokine-induced hormone resistance. 91. Huey, K. A., G. Fiscus, A. F. Richwine, R. W. Johnson, and B. M. Meador. (submitted) Vitamin E administration attenuates IL-6 PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 10 Biographical Sketch Format Page
  5. 5. Principal Investigator/Program Director (Last, First, Middle): Johnson, Rodney Wayne and IL-1β responses to an acute inflammatory insult in mouse skeletal and cardiac muscle. 92. Rosczyk, H., N. L. Sparkman, and R. W. Johnson. (submitted) Neuroinflammation and cognitive function in aged mice following minor surgery. 93. Krzyszton, C. P. N. L. Sparkman, R. W. Grant, J. B. Buchanan, S. R. Broussard, J. Woods, and R. W. Johnson (submitted) Exacerbated fatigue and motor deficits in interleukin-10 deficient mice after peripheral immune stimulation. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 11 Biographical Sketch Format Page
  6. 6. Principal Investigator/Program Director (Last, First, Middle): Johnson, Rodney Wayne Research Support Active PHS 1-R01-MH069148 (PI: Johnson) 07/01/03-04/30/2008 3.0 Cal. NIH/NIMH $225,000 Aging, brain cytokines and HIV-associated dementia The objective of this grant is to investigate if neurocognitive complications associated with HIV disease are exacerbated by other neurophysiologic changes that occur during “normal” aging. Overlap: none PHS 1-R01 2/1/04-1/31/09 0.6 Cal. NIH/NIDDKD $211,000 PI: G. Freund: Brain Immune Interactions in Type 2 DM The objective of this research project is to determine if type 2 DM induces a stress disorder that enhances brain responsivity to pro-inflammatory cytokines. Overlap: none PHS 1-R01-AG023580 (PI: Johnson) 01/01/05-12/31/09 1.2 Cal. NIH/NIA $205,000 Neuroimmune control of biobehavioral processes The goal of this project is to determine if performance deficits seen in normal aging are caused by inflammatory cytokines. Overlap: none PHS 1 R01 AG016710 (PI: Johnson) 09/06-08/11 1.2 Cal. NIH/NIA $250,000 Neuroinflammation and behavior in the aged The goal of this project is to determine if activation of the peripheral innate immune system in aged mice produces causes cognitive deficits and changes in hippocampal neuron morphology. PHS 1-R21-DA024443 (PI: Johnson) 09/01/07-08/31/09 0.5 Cal. NIH/NIDDA $150,000 Methamphetamine, HIV, neuroinflammation and behavior The goal of this project is to examine how methamphetamine and HIV interact to induce neuroinflammation. PHS 2T32 DK059802 07/01/08 - 3/31/13 0.6 Cal. NIH/NIDDKD $165,000 PD: S. Donovan: Training in inflammation and nutritional dysfunction. Support predoctoral training in inflammation and nutritional dysfunction. Pending: None PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 12 Biographical Sketch Format Page

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