In this webinar we introduce you to the workflows supported by Embase, describe the benefits of Embase content and coverage and show you how you may utilize deep drug indexing to pinpoint and track biomedical information.
MEDLINE you probably know and MEDLINE data is included in Embase, as well as unique Embase content, not found in MEDLINE. Will this additional content make a difference and most importantly lead you with more confidence to an answer? We will come back to this when in Embase later in the webinar.What about having the most up to date content when you carry out your search or including in regular email alerts? AiP/In Process and conference abstracts give you access to the most up to date research and we will show you how to integrate in your searches and email alerts later in the webinar. We now cover over 2.5K conferences with over 800K conference abstracts.
If your research is around Diabetes type II or non-insulin dependant Diabetes Mellitus as it is also known for example, then you need to include all published research but what if an author uses a different term to the one you used in your search? Emtree, our biomedical thesaurus automatically supports your search and will map your search terms so all synonyms are included in your search. Here you can see the enormous selection of terms available, over 60K with 29K being drug and chemical terms.Maybe not all synonyms are there yet? Emtree is updated 3 times a year so the chance of missing a term is considerably lower compared to databases which are updated once a year with new terms. Content is updated daily by the way, here we are talking about updating the thesaurus with new terms.
Here we see that studies directly related to levels of evidence used in evidence based medicine practice are included in Emtree, which means you can search for all RCTs indexed by our indexers, not just where they are mentioned or have to think of a sufficient search string to retrieve them. It is also possible to search for drugs and diseases within a specific context, such as drug combination, pharmacoeconomics, pharmaceutics, endogenous compound, disease management and epidemiology. Routes of drug administration may also be specifically searched for.
And now you have access to the biomedical literature and a huge selection of relevant index terms, how DO you find your answers?Quick Search allows easy and quick access to the best terms for your search...
And from the session results page, you can use the filters on the left of your results to further refine. Here you see the disease filter and we can see which diseases are referenced in our result set for Januvia, either as a therapeutic area or side effect.
Searching for specific types of content is also possible but using the field limits as seen here to search for conference name, conference date and conference location.You may also select conferences from the Publication Type limit or AiP. You will also notice AiP/In Process in Quick limits for even easier accessibility.
Don’t loose those important searches, register in Embase so you may save your searches or set up email alerts. Registering also means you receive all up to date information such as upcoming webinars.
ME: May I introduce Pierre. Pierre is a clinical liaison librarian, in the Information Services Biomedical Library, Center for Evidence-Based Research. They work with 3 main hospitals.Pierre, can you tell us more about your role and your main points of concern?PIERRE: It is many, for example, I instruct users in the use of library resources and management of information and I assist with literature searches on evidence-based practice issues, consulting with staff conducting systematic reviews with regards to search strategies. I serve as the primary library contact for many of the resources used by clinicians.My users are mainly involved in finding information from relevant and reliable sources regarding the effects of different forms of healthcare and they must be through when conducting this research and when publishing.ME: Are your users preparing articles for publication, particularly Systematic Review Articles. PIERRE: Yes and we hear more and more that journal editors and referees now stipulate that Embase searches are needed and authors publishing in the field of EBM, who need to follow Cochrane guidelines MUST conduct Embase searches. How can we best incorporate this into their workflow? Some users are still convinced that Medline is enough and some have even asked about Scopus. ME: Let’s have a look at the unique value Embase offers and also how easy it is to search with confidence!
We can now refer to the full text for more details, having already checked the relevance of the article to our clinical query , in Embase.
One of the major steps in conducting a systematic review is a comprehensive literature search. With Embase, all users, regardless of experience may enter the best term or terms to search, even on the Quick Search page. Entering the drug in a non-indexed database is possible but if you do not enter the generic name, there are no prompts in Scopus, used here as an example. A clinician trying to carry out a literature search alone, may know to use some of the commonly known terms for his search but maybe not all. Embase will help him/her select the term which automatically includes all the synonyms for that term.In Scopus, they are carrying out a free text search for januvia. I would like to point out that Scopus is an excellent all-science database with strengths in citation and author analysis for example but here we are looking at finding the best biomedical results and how indexing impacts your results.
Pubmed (MEDLINE) does allow thesaurus assistedsearching but here also we notice a difference in the number of results retrieved. Pubmed finds 132 results compared to 8,000 in Embase. We know there is unique content in Embase, the conference abstracts shown here for example,but there is also a difference in indexing focus and so Embase indexes more drugs, more deeply.
In Medline, this article although present in Medline is not indexed with digoxin and therefore our search for digoxin and antibacterial agents did not find this article. As we know already, it is found in Embase.
Antibiotic and digoxin with drug combinationANDCongestive heart failure with drug therapyAND PneumoniaSave this search – remove drug therapy from disease and rerun main searchNow in session results, remove drug comparison from drug sub-searches and note asterix (indicates which searches have been effected by a change to a related search)– now click on result number to update your search strategy.Compare the effectiveness of sitagliptin and saxagliptin in the treatment of type II diabetes mellitus (show this in Emtree)Go to Drug Search and type in sitagliptin and saxagliptin with drug comparison. Go to Emtree and show diabetes mellitus and then go to ‘type 2 diabetes mellitus’. Take this to Disease Search and combine with disease subheading ‘drug therapy’. Combine both searches.Show editing options. NOT [review]/limAdvanced combine on the Session Results: Last search above NOT saxagliptin search, for example #2 NOT #1.Quickly show Emtree to find suitable terms/subject headings and then using Drug Search to add subheadings.
Find disease management studies for Type II diabetesGo to Emtree and type in diabetes. Once you see the tree, select non-insulin dependant diabetes mellitus. Click on ‘take this to Disease search’. Point out ‘major focus’ option if users would like to limit their search to only records where the disease is of major importance and show on Disease Search form. Show quick and advanced limits.You can then add the subheading ‘disease management’. Check filters for drugs and study types.
An introduction to Embase
Welcome to our Embase webinar!Embase – Answers to your biomedical questions Your presenter: Ann-Marie Roche
Need to know• Webinar control panel: o‘chat’ or ‘ask a question’ for questions and comments o Option for full screen view• Q&A at the end
Our value story With over 24 million indexed records and more than 7,600 currently indexed peer-reviewed journals, Embase is a highly versatile, multipurpose and up-to-date databasecovering the most important international biomedical literature from 1947 to the present day.Core strengths of Embase include coverage and in-depth indexing of the drug-related and clinical literature, with a particular focus on comprehensive indexing of adverse drug reactions; emphasis on Evidence Based Medicine (EBM) indexing including systematic reviews, and coverage and indexing of journals and articles relevant to the development and use of medical devices. If you are searching for answers to your questions or simply need reliable, peer- reviewed information on topics such as drug development or use, toxicology, drug safety / adverse drug reactions, clinical trials, evidence based medicine, medical devices, pharmacoeconomics, preclinical reports, basic biomedical science or regulatory affairs, then Embase is the solution you are looking for.
How Embase delivers value…...by including literature and information Conference Scientific In Press We make sure you don’t resources in a timely manner proceedings Journals (unpublished) miss any biomedical literature ...by reading full-text to identify drugs, diseases, adverse Deep indexing using own They only close alternative is reading affects, clinical trials, drug trade names etc. taxonomy all the articles...by enabling advanced search filters to drill down a comprehensive search to a relevant and manageable record set Very powerful Good precision and recall balance Search Environment...by allowing users to automate searching Automation and and result management documentation E-mail Alerting API Interoperability 5
How Embase delivers value…Information overload Currency & Completeness Dispersed InformationWith a growing universe of scientific Information that can have impact on the future Information resources are dispersed acrossinformation, consumers have a hard time of a research project, development pipeline or different platforms, thus requiring multiplekeeping up with the latest information and existing business is of high value. Getting that searches to be executed and build in multipledetermining the value and reliability of that information complete and in time is critical. query languages. The more platforms, theinformation. Evidence Based Medicine is Pharma/ Device (co)vigilance is driven by more cumbersome to maintain and support.driven by the need to cope with information the need to have timely insight into potential Tools that help consolidate and searchoverload. adverse effects or new applications of a drug comprehensive files are in demand. or device How do we find the most valuable How do you make sure we capture How do you capture all the information? the most current information? information effectively? Research community Business community & regulators Information professionals By doing systematic By setting up structural By trying to reviews to searches and alerts to consolidate identify, appraise, select monitor for drug or searching andand synthesize all scientific device mentions storing on as few information systems as possible
Content Overview Emtree: Biomedical thesaurus, over 60k terms 1947 1950 1974 2009 Including Embase: Fully indexed: Over 7,700 journals (including MEDLINE), 1950- 5.5M not found in MEDLINE: 2,500 journals unique to Embase, mapped to Embase MEDLINE indexing, 1950- (including MEDLINE Classic) Embase Classic: AIP and In Process: Digitally scanned and Indexing added, from 2009 re-indexed, 1947-1973 Conference Abstracts: Indexing added, from 2009
Deep indexing - Emtree 60K terms (>260,000 synonyms) and all MeSH terms 29K drug and chemical terms Updated 3 times a year (back-posting each time) All drug generic names described by FDA and EMA, all International Non- Proprietary Names (INNs) described by WHO from 2000.What is mapping? Mapping means you retrieve the same results regardless ofwhich term you use e.g. Type II diabetes or non insulin dependant diabetesmellitus.
Deep indexing - Emtree 14 study types, including NEW Diagnostic Test Accuracy Study 78 drug and disease subheadings
Case study•A clinician is working on a systematic review for publication.She needs to adhere to certain guidelines to ensure she hasconducted a through search of the literature.http://www.youtube.com/watch?v=QzZbYMS1tQ4Question•Are there any risks associated with the administration ofantibiotics together with digoxin in a patient with congestiveheart failure who has contracted pneumonia?
• Articles like this contain vital information...
2 sets of results…Why arethe results so different and does it matter…?
23 synonyms as well as ‘antibacterial agent’ aresearched simultaneously as well as over 38 narrower terms (including moxifloxacin). No simultaneous searching of synonyms or narrower terms= Only ‘antibacterial agent’ is searched and this does not find all the vital information
Found in your Embase results, not in yournon-indexed supported search...
2 thesaurus assisted searchesbut different results? Embase has unique content ,such as conference abstracts.
Found in your Embase search,not in your MEDLINE search... We are looking for digoxin AND ‘antibacterial agent’ but Medline does NOT index digoxin in this article.
PollThe poll should appear on your screen shortly...
Let’s take a look at Embase...…by going to www.embase.com
Building and combining searches• Use single quotes to capture a phrase ‘diabetes mellitus’ for example (not with Autocomplete in Quick Search)• Break up your search into individual searches, such as a drug search (in Drug Search form) and a disease search (in Disease Search form) and combine your results in Session Results• Run your cursor over your search to Edit or copy to a Search Form for guided editing.• Truncation and operators, AND, OR, NOT, NEXT, NEAR Refer to http://info.embase.com/helpfiles for more guidance and links to materials such as the Quick User Guide.
Refining your search• Quick and Advanced Limits on Advanced, Drug and Disease Search forms• Major Focus on all advanced forms – major drugs and diseases retrieved• Field limits under Advanced Search box to search in specific fields such as article title, abstract, conference name, drug name etc• Drug and Disease Subheadings to limit to specific concepts such as Adverse Drug Reaction, Drug Comparison and Side Effect.• Filters on Session Results page for specific diseases or study types for example Check out our training videos at www.trainingdesk.elsevier.com/embase for more guidance.
Thank you and see you next time• Q&A will be sent to you by email and for more information and questions please contact firstname.lastname@example.org• Embase webinars occur on the 04th Wednesday of every month and our next webinar Train the trainer is aimed at trainers.• Go to www.trainingdesk.elsevier.com/embase for all training related materials Please fill out the survey that appears on your screen after leaving the webinar.