• Share
  • Email
  • Embed
  • Like
  • Save
  • Private Content
Miniature Drug Delivery System Patent Search and Analysis Report
 

Miniature Drug Delivery System Patent Search and Analysis Report

on

  • 1,007 views

Miniature Drug delivery System uses micro-fabricated devices to administer drugs to the host and has advantages over a conventional drug delivery ...

Miniature Drug delivery System uses micro-fabricated devices to administer drugs to the host and has advantages over a conventional drug delivery

system.

A MEMS based Implantable Drug Delivery System (IDDS) is discussed. The heart of the system is an in-plane MEMS micropumps enables us to make a

compact, inexpensive system. A conceptual IDDS design is proposed. This design consists of an implantable unit which houses the micropumps,

electronic and power circuitry. This implantable unit is connected to a subcutaneous port via a silicone catheter. The subcutaneous port acts as

a refillable reservoir. This leads to a reduction in unit volume and makes the system customizable. The IDDS pumps drug into surrounding tissue

with the help of a MEMS based micropumps. Similarly Microneedles are also used in drug administration.

This report gives an overview of patenting activity around Miniature Drug Delivery System. Smart drug delivery system is used for delivering

drugs to the host effectively and improves the quality of life of the patients. Patents were categorized as per key Drug Delivery administration

methods, types of sensors, applications, communication techniques and analyzed for generating different trends with Patent iNSIGHT Pro.

Miniature Drug Delivery System technology has seen a consistent increase in the number of patent publications from 2008 till 2012 as the need for

smart drug delivery has increase globally.

Statistics

Views

Total Views
1,007
Views on SlideShare
1,007
Embed Views
0

Actions

Likes
0
Downloads
8
Comments
0

0 Embeds 0

No embeds

Accessibility

Categories

Upload Details

Uploaded via as Adobe PDF

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

    Miniature Drug Delivery System Patent Search and Analysis Report Miniature Drug Delivery System Patent Search and Analysis Report Document Transcript

    • Page 1 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comMiniature Drug DeliverySystemMiniature or smart drug delivery system is used to deliver drugs to apatient using the biological information. This info is detected with the helpof various sensors. MEMS & NEMS technology is used for delivery.Bio-MEMS typically focuses on mechanical parts and microfabricationtechnologies made suitable for biological applications. A broad definitionfor bio-MEMS can be used to refer to the science and technology ofoperating at the microscale for biological and biomedical applications,which may or may not include any electronic or mechanical functions.This report takes a look into the patenting activity around miniature/smartdrug delivery system, uncovering the key companies, inventors, anddifferent sub categories.Technology Insight ReportDisclaimer: This report should not be construed as business advice and the insights are not to be used as the basisfor investment or business decisions of any kind without your own research and validation. Gridlogics TechnologiesPvt. Ltd disclaims all warranties whether express, implied or statutory, of reliability, accuracy or completeness ofresults, with regards to the information contained in this report.
    • Page 2 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comIntroduction to Miniature drug delivery systemNanoelectromechanical systems (NEMS) are devices integrating electrical and mechanicalfunctionality on the nanoscale. NEMS form the logical next miniaturization step from so-calledelectromechanical system, or MEMS devices. NEMS typically integrate transistor-like nanoelectronics with mechanical actuators, pumps, or motors, and may thereby formphysical, biological, and chemical sensors. The name derives from typical device dimensions inthe nanometer range, leading to low mass, high mechanical resonance frequencies, potentiallylarge quantum mechanical effects such as zero point motion, and a high surface-to-volume ratiouseful for surface-based sensing mechanisms.Microelectromechanical systems (MEMS) also referred to as micro-electro-mechanical,MicroElectroMechanical or microelectronic and microelectromechanical systems) is thetechnology of very small devices; it merges at the nano-scale into nanoelectromechanicalsystems (NEMS) and nanotechnology. MEMS are also referred to as micromachines, or microsystems technology – MST.MEMS & NEMS based micropumps and microneedles are extensively used. These help toadminister accurate doses effectively. Sensors and different communication techniques are usedto felicitate the precise diagnosis and treatment.OverviewWith the help of Patent iNSIGHT Pro, we will analyze the patent data around miniature drugdelivery to find answers to the following:What does the IP publication trend for miniature drug delivery look like and how havethe filings evolved?Who are the top assignees or key players in miniature drug delivery and what are theirtechnology wise trends?How is research in miniature drug delivery spread across different countries?What are the different types of sensors used by various companies?How different methods of drug delivery used for various applications?How is the company portfolio spread across different applications?
    • Page 3 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comPatent CategorizationTo get deeper insights the patent set has been classified as follows:Methods-Drug DeliveryExternalInternalProgrammableTimedSensorsAmperometricBio-SensorsCalorimetricElectro-OpticFlowGlucoseImpedancePhoto-ReflectivePressureTemperatureMicropumpOsmoticPiezoelectricValveMicroneedleHollowPorousSolidStacked ConfigurationCommunication SystemBluetoothOpticalRadio Frequency (RF)WirelessApplicationsAtherosclerosisBlood InfectionCancerCardiacCoronary Artery DiseaseDermal DisorderDiabetesHypertensionMuscleNeurologicalPeripheral Vascular DiseaseSkinTraversing Alimentary Tract
    • Page 4 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comThe illustration below shows the different categories prepared and the number of records ineach. The categorization involved defining a search strategy for each topic and then conductingthe search using the Advanced Searching capability in Patent iNSIGHT Pro. Details of searchstrings used for each category are given in Appendix A.CATEGORIZATION TREE
    • Page 5 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comSearch StrategyUsing the commercial patent database PatSeer as our data source we used the following searchquery to create our patent set.TAC – Title Abstract ClaimsC-ClaimsIC- International ClassificationPBY- Publication YearThe queries were combined using the ‘OR’ operator to search intitle, abstract, claims and a patent set of 2545 records with onepublication per family was generated.The publications included in the report are updated as of14th March, 2013.TAC:(Microelectromechanical* or Micropump* ornanopump* or Microneedle* or nanoneedle* orsensor* or nanoject* or Microosmotic* or "MEMS" or"BioMEMS" or "micro-electro-mechanical" ormicroelectronic* or ("transdermal micro needle"%3 OR"transdermal microneedle*"%3) or ("(micro or nano)(system* or technology or pump* orelectromechanical* or needle* or medic* or osmotic*or sensor*)"%3) or nanoelectromechanical or "NEMS"or "BioNEMS" )ANDC:(("(drug* or pharma* or medic*) (inject* or deliver*or infuse* or diffuse* or perfuse* or releas* or syringe*or implant*)"%3))ANDIC:(A61M37/00 or A61K9/00 or A61K9/16 orA61P35/00 or A61M5/142 or A61K9/14 or A61M31/00or A61K47/34 or A61M5/00 or A61B5/00 or A61K47/36or A61K9/22 or A61K9/52 or A61K9/51)AND(PBY: [1990 TO 2013])Class Descriptions of Classes used in SearchStrategyA61K9/00: Medicinal preparations characterizedby special physical formA61M37/00: Other apparatus for introducingmedia into the body (for reproduction orfertilisationA61K9/16: Agglomerates; Granulates;MicrobeadletsA61P35/00: Antineoplastic agentsA61M5/142: Pressure infusion, e.g. using pumpsA61K9/14: Particulate form, e.g. powders(microcapsules A61K 9/50)A61M31/00: Devices for introducing or retainingmedia, e.g. remedies, in cavities of the bodyA61K47/34: Macromolecular compoundsobtained otherwise than by reactions onlyinvolving carbon-to-carbon unsaturated bondsA61M5/00: Devices for bringing media into thebody in a subcutaneous, intra-vascular orintramuscular wayA61B5/00: Measuring for diagnostic purposes(radiation diagnosis A61B 6/00; diagnosis byultrasonic, sonic or infrasonic waves A61B 8/00);Identification of personsA61K47/36: Polysaccharides; Derivatives thereofA61K9/22: Sustained or differential release typeA61K 9/50: MicrocapsulesA61K 9/50: Nanocapsules
    • Page 6 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comPublication TrendWhat has been the IP publication trend for miniature drug delivery system?The data shows an overall peak of patent activity in 2010.We can see that there are two periodsof growth in the last 10 years confirming that since the turn of the century the overall trend isfor a rise in the number of applications being published.The initial phase (1990-2002) in this field lasted up to the year 2002 having around 40publications during these years. This initial phase was followed by a transition phase (2003-2008) resulting in substantial increase in the patenting activity with around 145 publications.The transition phase, in turn, was followed by a period of very large number of publicationsduring the period 2009-2012 showing a huge increase in patenting activity reaching 225publications in just three years. Year 2010 comes out to be the year where there were thehighest number of publications followed by years 2009, 2012 and 2008.How we did it?Once the patents were populated in Patent iNSIGHT Pro, the publication trend chart was generated on asingle click using the dashboard tool.
    • Page 7 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comTop AssigneesWho have been the top assignees or the key players within this industry?The top assignees are:How we did it?Once the patents were populated in Patent iNSIGHT Pro, the assignee clean- up tools were used tonormalize the names. Different cleanup tools were leveraged:• To locate assignees for unassigned records• To clean up records having multiple assignees• To locate the correct assignee names for US records using the US assignments databaseOnce the Assignee names were cleaned up, the dashboard tool within Patent iNSIGHT Pro was used tofind the top 20 assignees within the given patent set. A visual graph was created based on the results ofthe top assignees with the number of patents alongside each one.The complete Assignee table in available in the following Excel file:http://www.patentinsightpro.com/techreports/0313/List%20of%20Assignees.xls11. BECTON DICKINSON & CO12. MILUX HOLDING SA13. UNIV SHANGHAI14. SEARETE LLC15. 3M CO16. ROCHE HOLDING AG17. BOSTON SCIENTIFIC CORP18. UNIV CALIFORNIA19. DEXCOM INC20. UNIV TSINGHUA1. MEDTRONIC INC2. CARDIAC PACEMAKERS INC3. PHILIPS CORP4. ABBOTT LAB5. PACESETTER INC6. NOVO NORDISK AS7. BAXTER INTERNATIONAL INC8. MICROCHIPS INC9. SANOFI SA10. ALZA CORP
    • Page 8 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comTop CountriesHow is research around miniature drug delivery spread across different countries?In terms of regional pockets where patent protection is being sought most frequently for thesetechnologies, US leads the count, followed by the CN and EP .The table below ranks top prioritycountries and helps provide an indication of where innovation in this area is originating:How we did it?The map was generated using the Priority country coverage map option provided in the dashboard toolwithin Patent iNSIGHT Pro.CountryCodeTotalUS 1695CN 301EP 92GB 52AU 38
    • Page 9 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comCompanies - Key StatisticsHere we summarize key parameters of Top 15 companies such as filing trend, Avg. number ofForward citations per record, Top inventors in each Assignee, Top Co-Assignees and Coverage ofunderlying patent familiesAssigneeTotal No.of RecordsAvg.No. ofFwdCitesperPatentsFiling Trend( Cumulative)FilingYearRangeKey Inventor(Top 5)Co-AssigneesCoverage(Includes families)USEPJPDECNAUKRMEDTRONICINC254 (10%)5.58 1993-2012MIESELKEITH A(28)HERUTHKENNETHT(15)GERBERMARTINT(14)DENISONTIMOTHYJ(12)CINBISCAN(11)INST NAT SANTERECH MED(1)MARKOWITZ HTOBY(1)234 137 47 54 14 32 1CARDIACPACEMAKERSINC67 (2.6%) 1.732001-2011STAHMANNJEFFREYE(11)HATLESTADJOHN D(9)LEE KENT(8)VON ARXJEFFREY A(8)HARTLEYJESSE W(7)No Co-AssigneePresent65 38 33 4 2 18 0PHILIPS CORP 34 (1.3%) 0.262005-2011NISATOGIOVANNI(7)IORDANOVVENTZESLAVP(6)KRIJNSENHENDRIKAC(6)VANBRUGGENMICHEL PB(6)KASSIESROELF(6)JANNER ANNA-MARIA(2)RUBINGH JAN-ERIC J M(1)17 21 18 1 19 0 0
    • Page 10 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comABBOTT LAB 31 (1.2%) 0.71 1995-2011HAYTERGARY(4)ELSTROMTUAN A(3)HENNINGTIMOTHYP(3)RUSHBENJAMIN(3)SHAIN ERICB(3)No Co-AssigneePresent29 15 7 4 6 9 0PACESETTERINC26 (1%) 18.61987-2011KOHSTEVE(4)EIGLER NEALL(3)MANNBRIAN(3)TURCOTTROBERT(3)COLMANFREDRICC(2)No Co-AssigneePresent24 12 5 6 0 2 0NOVONORDISK AS25 (1%) 5.121991-2012NIELSEN OLECHRISTIAN(8)PREUTHUNJANHARALD(5)RADMERJIM(5)BENGTSSONHENRIK(4)POULSENJENSULRIK(4)INST OFBIOCYBERNETICS AND BIO(1)TEISEN-SIMONYCLAUDE(1)17 18 8 8 7 6 3BAXTERINTERNATIONAL INC24 (0.9%) 0.211988-2010JACOBSONJAMES D(5)STEWARTJANICE(5)BELLODEBRA K(4)BUI TUAN(4)MEINZERRANDOLPH(4)No Co-AssigneePresent16 18 15 7 12 20 2MICROCHIPSINC22 (0.9%) 3.552000-2009HERMANSTEPHENJ(10)SANTINIJOHN T JR(9)SANTINI JRJOHN T(8)SHEPPARDNORMAN FJR(6)UHLANDSCOTT A(6)No Co-AssigneePresent22 15 9 9 3 15 2
    • Page 11 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comSANOFI SA 19 (0.7%) 0.051990-2012RICHTERRENE(7)NAGELTHOMAS(4)WITTROBERT(4)BASSONILS(3)CLARKEALASTAIR(2)No Co-AssigneePresent11 14 10 4 9 10 6ALZA CORP 18 (0.7%) 2.561992-2007CORMIERMICHEL JN(2)MARIKAKAMBERI(2)PETERDADDONA(2)RAJANPATEL(1)WONGPATRICK SL(1)No Co-AssigneePresent16 15 15 2 17 15 11BECTONDICKINSON &CO18 (0.7%) 4.671999-2010PETTISRONALD J(9)DOWNJAMES A(3)HARVEYNOEL G(3)SEARLEGARY(3)MIKSZTAJOHN A(3)HARVEY NOELG(1)16 15 13 7 7 12 1MILUXHOLDING SA17 (0.7%) 0.122009-2010FORSELLPETER(16)PETERFORSELL(1)No Co-AssigneePresent15 15 2 0 2 6 0UNIVSHANGHAIJIAOTONG16 (0.6%) 02004-2012HONGZHUAN CHEN(5)CHAOFANG(4)DEHONGYU(4)QIN LU(4)FAN BAI(3)No Co-AssigneePresent0 0 0 0 16 0 0SEARETE LLC 15 (0.6%) 0.732004-2011WOOD JRLOWELLL(12)HYDERODERICKA(11)ISHIKAWAMURIEL Y(9)WOODVICTORIA YH(9)SWEENEYNo Co-AssigneePresent15 2 1 0 0 0 1
    • Page 12 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comHow we did it?From the Assignee 360° report options, we selected Top 15 Assignees and the different pieces ofinformation we wanted to include in the singular display and then ran the report. The generated reportwas then exported to Excel using the option provided for the same.ELIZABETHA(9)3M CO 13 (0.5%) 2.621998-2012FREDERICKSONFRANKLYNL(4)DUANDANIEL C(3)CARTERCHAD J(2)JOHNSONPETER R(2)KEISTERJAMIESONC(1)ERDOGAN-HAUG BELMA(1)8 9 6 2 4 7 2
    • Page 13 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comInventor - Key StatisticsHere we summarize key parameters of Top 15 Inventors such as filing trend, average number offorward citations per record, key associated companies and top 5 co-inventors.InventorTotalNo. ofRecordsAvg.No. ofFwdCitesperPatentsFiling Trend(Cumulative)FilingYearRangeKey Assignees(Top 5)Co-InventorsMIESELKEITH A29(1.1%)10.551998-2011MEDTRONICINC(28)GEIGER MARKALLEN(1)KINGHORNCURTIS D.(1)LECKRONEMICHAELEUGENE(1)MIESEL KEITHALAN(1)HERUTH KENNETH T(9)STYLOS LEE(6)DENISON TIMOTHY J(3)ALI IRFAN Z(2)CHRISTOPHERSON MARKA(2)FORSELLPETER19(0.7%)0.112003-2010MILUX HOLDINGSA(16)PROSTHESICAAG(2)INJECTICA AG(1)No Co-Inventor PresentSTAHMANNJEFFREY E16(0.6%)52002-2011CARDIACPACEMAKERSINC(11)STAHMANNJEFFREY E.(3)LEE KENT(2)NI QUAN(2)STAHMANNJEFFREY E(2)HARTLEY JESSE W(8)LEE KENT(7)NI QUAN(7)HATLESTAD JOHN D(5)ZHU QINGSHENG(4)GERBERMARTIN T15(0.6%)1.42002-2010MEDTRONICINC(14)GERBERMARTIN(1)OLESONKIMBERLY(1)RONDONI JOHN C(9)OLESON KIMBERLY(1)HERUTHKENNETH T15(0.6%)31999-2011MEDTRONICINC(15)MIESEL KEITH A(9)LENT MARK S(4)BLANCO JUSTIN A(2)GRAVES NINA M(2)LAPORTE STEVE R(2)
    • Page 14 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comWOOD JRLOWELL L15(0.6%)0.272004-2011SEARETE LLC(12)INVENTIONSCIENCE FUND ILLC(2)HYDE RODERICKA(1)ISHIKAWAMURIEL Y(1)LEUTHARDT ERICC(1)HYDE RODERICK A(12)ISHIKAWA MURIEL Y(11)WOOD VICTORIA Y H(10)LEUTHARDT ERIC C(9)SWEENEY ELIZABETH A(9)CINBIS CAN13(0.5%)0.542006-2012MEDTRONICINC(11)CARNEY JAMESK(2)CINBIS CAN(2)SCHUGT MICHAELA(1)YE QINGSHAN(1)CARNEY JAMES K(6)KUHN JONATHAN L(6)ANDERSON DAVID A(3)DAVIS TIMOTHY J(3)ECKER ROBERT M(3)PETTISRONALD J13(0.5%)1.382001-2007BECTONDICKINSON &CO(9)PETTIS RONALDJ.(3)HARVEY NOELG(2)ALCHAS PAULG.(2)DOWN JAMES(2)HARVEY NOEL G(7)DOWN JAMES A(6)ALCHAS PAUL G(3)FERRITER MATTHEW S(2)MARTIN FRANK(2)DENISONTIMOTHY J12(0.5%)1.672007-2011MEDTRONICINC(12)MIESEL KEITH A(3)SANTA WESLEY A(3)MOLNAR GREGORY F(2)ANDERSON JOEL A(1)CONG PENG(1)HATLESTADJOHN D12(0.5%)42002-2011CARDIACPACEMAKERSINC(9)HATLESTAD JOHND(2)HATLESTADJOHN(1)STAHMANNJEFFREY E.(1)ZHUQINGSHENG(1)STAHMANN JEFFREY E(5)ZHU QINGSHENG(4)LEE KENT(3)SIEJKO KRZYSZTOF Z(3)COOK JEFFREY P(2)HYDERODERICK A12(0.5%)0.172007-2011SEARETE LLC(11)HYDE RODERICKA(1)ISHIKAWAMURIEL Y(1)LEUTHARDT ERICC(1)SMITH MICHAELA(1)WOOD JR LOWELL L(12)ISHIKAWA MURIEL Y(10)WOOD VICTORIA Y H(10)LEUTHARDT ERIC C(9)KARE JORDIN T(8)
    • Page 15 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comHERMANSTEPHEN J11(0.4%)2.092001-2009MICROCHIPSINC(10)GENZYMECORP(1)SANTINI JR JOHN T(5)AUSIELLO DENNIS(3)POLITO BENJAMIN F(3)SANTINI JOHN T JR(3)UHLAND SCOTT A(3)HICKLERANDALL S11(0.4%)1.271999-2012SCOTT LABINC(10)ETHICON INC(1)COBB NICHOLAS E(2)ADAIR W PATRICK(1)ADAIR WILLIAM P(1)BISHOP GREGORY D(1)BRUGGEMAN PAUL J(1)ISHIKAWAMURIEL Y11(0.4%)0.182007-2011SEARETE LLC(9)HYDE RODERICKA(1)ISHIKAWAMURIEL Y(1)LEUTHARDT ERICC(1)SMITH MICHAELA(1)WOOD JR LOWELL L(11)HYDE RODERICK A(10)WOOD VICTORIA Y H(10)LEUTHARDT ERIC C(9)KARE JORDIN T(7)THOMPSONDAVID L11(0.4%)30.21993-2011MEDTRONICINC(11)GOEDEKE STEVEN D(3)GREENINGER DANIEL R(2)BLAHA ERIC V(1)BONDE ERIC(1)COBIAN RYAN(1)How we did it?From the Inventor 360° report options, we selected the different pieces of information we wanted toinclude in the singular display and then ran the report. The generated report was then exported to Excelusing the option provided for the same.
    • Page 16 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comDrug Delivery: Company focus across various sensorsWhat are the different types of sensors used by various companies?Chart shows that pressure sensors are the most favored sensors amongstinventors/applicants in sensors technology space.Use of pressure sensor by most of the companies.Research around pressure sensors is fairly saturated followed by flow and glucosesensors.How we did it?The clusters that were created for analysis were correlated using the co‐occurrence analyzer and then theresulting matrix was converted into a 3-D column chart.
    • Page 17 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comDrug Delivery: Applications across various sensorsHow are various sensors spread across different applications?Pressure, temperature & glucose sensors are the most used sensors.There is substantial potential for research amongst other types of sensors as comparedto the top 3 typesHow we did it?The clusters that were created for analysis were correlated using the co‐occurrence analyzer and then theresulting matrix was converted into a clustered column chart.
    • Page 18 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comDrug Delivery: Company focus across micropumpsHow is the Assignee portfolio spread across different micropumps?Chart below shows that osmotic and valve micropumps are widely used.Principal AB has research focused on piezoelectric pumps; whereas Medtronics hasresearch interest in all the types of micropumps.How we did it?The clusters that were created are correlated using the co‐occurrence analyzer and the resulting matrixwas converted into a Stacked Column chart.
    • Page 19 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comDrug Delivery: Company across various applicationsHow is the Assignee portfolio spread across different applications?Chart below shows that all the companies except ST Jude Medical and Pacesetter Inchave developed technologies to administer drugs through/to skin.It can also be seen that there is minimal research around neurological, TraversingAlimentary Tract and Peripheral Vascular Disease drug administration.How we did it?The clusters that were created were correlated using the co‐occurrence analyzer and then the resultingmatrix was converted into a bubble chart.
    • Page 20 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comDrug Delivery: Applications Vs MethodsWhich methods are used across key application areas?Chart below shows the different methods used to administer drugs for specific diseases.
    • Page 21 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comHow we did it?The clusters that were created were correlated using the co‐occurrence analyzer and the resulting matrixwas converted into a 4-D Matrix containing methods of drug delivery and some filtered applications,publication year and results were restricted to last decade.
    • Page 22 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comDrug Delivery: Company focus across various types ofmicroneedlesHow is the company portfolio spread across different microneedles?Chart below shows that there is extensive research activity around Hollowmicroneedles.How we did it?The clusters that were created were correlated using the co‐occurrence analyzer and then the resultingmatrix was represented as stacked column area.
    • Page 23 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comAnalysis across different technologiesThe matrixes below show the filing trend, top companies and Inventors across respectivetechnologies.From the Technology 360° report options, we selected the different pieces of informationwe wanted to include in the singular display and then ran the report. The generated reportswere then exported to Excel using the option provided for the same.ApplicationsApplicationsTotalNo. ofRecordsAvg.No. ofFwdCitesperPatentsFilingYearRangeTop 5 Assignees Top 5 InventorsSkin518(20.4%)3.421989-2012MEDTRONIC INC(17)MILUX HOLDING SA(15)BECTON DICKINSON & CO(13)NOVO NORDISK AS(11)ABBOTT LAB(9)FORSELL PETER(16)PETTIS RONALD J(11)MIESEL KEITH A(7)BITTON GABRIEL(7)NAGAR RON(7)Cancer221(8.7%)0.691988-2012NOVARTIS AG(5)ALZA CORP(4)EURO CELTIQUE SA(4)UNIV CALIFORNIA(4)UNIV SHANGHAI JIAOTONG(4)DRIZEN ALAN(4)QIN LU(3)HOLGER PETERSEN(3)CHASIN MARK(3)MARKUS AHLHEIM(3)Muscle213(8.4%)2.411988-2012MILUX HOLDING SA(15)MEDTRONIC INC(14)BIOSENSE INC(4)PNEUMOFLEX SYSTEMS LLC(4)ALLERGAN INC(3)FORSELL PETER(15)ADDINGTON ROBERT(4)MILLER STUART(4)STEPHENS ROBERT(4)ZHOU XIAOHONG(3)Cardiac175(6.9%)5.771988-2012MEDTRONIC INC(30)CARDIAC PACEMAKERS INC(24)PACESETTER INC(9)ST JUDE MEDICAL INC(8)BIOSENSE INC(5)FISCHELL DAVID R(6)CARLSON GERRARD M(6)STAHMANN JEFFREY E(6)BROCKWAY MARINA(5)HATLESTAD JOHN D(5)Diabetes157(6.2%)2.591988-2012MEDTRONIC INC(7)ABBOTT LAB(7)BECTON DICKINSON & CO(5)INSULINE MEDICAL LTD(4)NOVO NORDISK AS(4)BITTON GABRIEL(5)NAGAR RON(5)PESACH BENNY(5)WEISS RAM(3)PALMER CYNTHIA LOUISE(2)Dermal Disorder127(5%)4.81989-2012BECTON DICKINSON & CO(8)ALZA CORP(6)ELAN CORP PLC(5)PRINCIPAL AB(3)PETTIS RONALD J(10)HARVEY NOEL G(5)DOWN JAMES A(5)GROSS JOSEPH(5)
    • Page 24 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comUNIV RUTGERS(3) KELLY JOHN GERARD(4)Hypertension120(4.7%)1.291987-2012MEDTRONIC INC(5)ZHANG QINGLONG(3)ALTEA THERAPEUTICS CORP(3)NITROMED INC(3)ACIST MEDICAL SYS INC(3)EPPSTEIN JONATHAN A(4)GARVEY DAVID S(4)ZHANG QINGLONG(3)SMITH ALAN(3)WILSON ROBERT F(2)Coronary ArteryDisease105(4.1%)3.71988-2011MEDTRONIC INC(13)CARDIAC PACEMAKERS INC(7)BIOSENSE INC(5)BIOTRONIK CRM PATENT AG(3)MATREGEN CORP(2)FISCHELL DAVID R(3)ROSS JEFFREY(3)MATCOVITCH AVRAHAM(3)CAFFERATA ROBERT(3)YARON URI(3)Blood Infection92(3.6%)1.11989-2010ALTEA THERAPEUTICS CORP(3)GENENTECH INC(2)UNIV TEXAS(2)SPECTRX INC(2)MEDTRONIC INC(2)EPPSTEIN JONATHAN A(3)HATCH MICHAEL R(3)BORCHARDT ALLEN J(2)MCALLISTER DEVIN V(2)KANIA ROBERT STEVEN(2)PeripheralVascular Disease31(1.2%)2.842000-2011ANGIOTECH INT AG(2)ENDOBIONICS INC(2)NITROMED INC(2)MICHIGAN CRITICAL CARECONSULT(1)MOR RESEARCH APPLIC LTD(1)GARVEY DAVID S(3)GOLD MARK S(2)MELKER RICHARD J(2)SACKELLARES JAMES C(2)BARR LYNN MATEEL(2)Atherosclerosis 26 (1%) 1.51999-2011UNIV SHANGHAI JIAOTONG(3)NITROMED INC(2)UNIV MICHIGAN(1)ANGIOTECH INT AG(1)UNIV MARYLAND(1)FAN BAI(3)HONGZHUAN CHEN(3)MEI ZHAO(3)QIN LU(3)GARVEY DAVID S(3)Vaccination9(0.4%)02001-2012OXFORD GLYCOSCIENCES UKLTD(1)ALZA CORP(1)US GOV HEALTH & HUMANSERV(1)UCB PHARMA SA(1)SANOFI SA(1)CHAMBERS RICHARD C(1)SCHLOM JEFFREY(1)OKULAN NIHAT(1)STAMPS ALASDAIR CRAIG(1)CIGARINI SANDRINE(1)Neurological5(0.2%)1.62003-2010MEDTRONIC INC(2)WILLENBRING JAMES E(1)HOBBS JONATHAN P(1)NEUROPACE INC(1)AUDET SARAH A(1)GOTTESMAN JANELL M(1)HILL GERARD J(1)MANRODT CHRISTOPHER M(1)MARKOWITZ H T(1)RUETER JOHN C(1)TraversingAlimentary Tract2(0.1%)0 2006PHILIPS CORP(2) NAAMAT JUDY RUTH(2)TROVATO KAREN I(2)HERZKA DANIEL(1)OUWERKERK MARTIN(1)
    • Page 25 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comSensorsSensorsTotalNo. ofRecordsAvg.No. ofFwdCitesperPatentsFilingYearRangeTop 5 Assignees Top 5 InventorsPressure 431 6.011986-2012MEDTRONIC INC(52)MILUX HOLDING SA(15)CARDIAC PACEMAKERS INC(14)PACESETTER INC(10)BIOSENSE INC(5)FORSELL PETER(16)MIESEL KEITH A(12)STYLOS LEE(6)GROSS JOSEPH(6)HETTRICK DOUGLAS A(5)Temperature 256 6.631988-2012MEDTRONIC INC(22)CARDIAC PACEMAKERS INC(7)ZARS INC(6)INSULINE MEDICAL LTD(5)EKOS CORP(5)MIESEL KEITH A(6)BITTON GABRIEL(5)NAGAR RON(5)PESACH BENNY(5)ZHANG JIE(5)Flow 145 6.121986-2012MEDTRONIC INC(8)SANOFI SA(6)HOSPIRA INC(5)MINIPUMPS LLC(4)SENSILE PAT AG(3)RICHTER RENE(6)CAFFEY SEAN(5)NAGEL THOMAS(4)WITT ROBERT(4)JACOBSON JAMES D(4)Glucose 127 7.311988-2012MEDTRONIC INC(21)ABBOTT LAB(11)DEXCOM INC(10)MINIMED INC(5)INSULINE MEDICAL LTD(4)LEBEL RONALD J(7)BRAUKER JAMES H(7)STARKWEATHER TIMOTHY J(6)WEISS PHILLIP T(6)KAMATH APURV U(6)Impedance 73 5.481989-2012MEDTRONIC INC(18)CARDIAC PACEMAKERS INC(10)PACESETTER INC(3)BROCKWAY MARINA(2)HERNDON TERRY O(2)CHO YONG KYUN(4)BROCKWAY MARINA(4)SALO RODNEY(3)ZHANG YI(3)CARLSON GERRARD M(3)Photo-Reflective 55 14.331988-2011MEDTRONIC INC(5)BAXTER INTERNATIONAL INC(3)BIOSENSE INC(2)FORHEALTH TECHNOLOGIESINC(2)FLAHERTY J C(2)DAVIS TIMOTHY J(3)REINKE JAMES D(3)FLAHERTY J C(2)NASIRI ABDOLHOSEIN(2)QUN LI(2)Bio Sensors 51 8.271991-2012MEDTRONIC INC(10)HERBST EWA(3)CARDIAC PACEMAKERS INC(3)CARDIOMEMS INC(3)BIOSENSE INC(2)DENISON TIMOTHY J(4)WHITE JASON(3)HERBST EWA(3)HILL GERARD J(3)ZHANGMIN YANG(2)Amperometric 48 6.521995-2011ABBOTT LAB(4)DEXCOM INC(3)MEDTRONIC INC(3)UNIV CONNECTICUT(2)HAN IN SUK(3)HUNTER WILLIAM L(3)MAGDA JULES JOHN(3)SHAH RAJIV(3)
    • Page 26 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comBIOTECH INC M(2) GONNELLI ROBERT R(3)Calorimetric 14 0.431996-2011UNIV RUTGERS(2)AVENTIS PHARMA LTD(1)MILLENNIUM PHARMA INC(1)DOW GLOBAL TECHNOLOGIESINC(1)ARX JEFFREY ALLEN VON(1)KOHN JOACHIM B(2)KWOK JONATHAN(1)LECHUGA-BALLESTEROSDAVID(1)HENGERER ARNE(1)PATTON JOHN S(1)Electro-Optic 11 5.271994-2012PRINCIPAL AB(3)BIOTRONIK CRM PATENT AG(2)GERRANS LAWRENCE J(1)GUNDAY ERHAN H(1)CARDIAC PACEMAKERS INC(1)SVEDMAN PAL(3)DOERR THOMAS(2)WEISS INGO(2)WOOD JR LOWELL L(1)GERRANS LAWRENCE J(1)CommunicationCommunicationTotalNo. ofRecordsAvg.No. ofFwdCitesperPatentsFilingYearRangeTop 5 Assignees Top 5 InventorsWireless 190 6.251989-2012MEDTRONIC INC(19)CARDIAC PACEMAKERS INC(12)ABBOTT LAB(5)BAXTER INTERNATIONAL INC(4)PHILIPS CORP(4)VON ARX JEFFREY A(5)CHAVAN ABHI(5)MAILE KEITH R(5)FISCHELL DAVID R(4)HILL GERARD J(4)RadioFrequency(RF)47 3.661996-2012MEDTRONIC INC(7)CARDIAC PACEMAKERS INC(6)HITACHI GLOBAL STORAGETECHNOLOGIES LTD(4)ABBOTT LAB(3)DEXCOM INC(2)VON ARX JEFFREY A(5)FELISS NORBERT(4)GILLIS DONALD RAY(4)CHAVAN ABHI(3)MAZAR SCOTT T(3)Optical 25 3.21999-2012MEDTRONIC INC(2)GUILLORY K S(1)SERRUYA MIJAIL D(1)CARDIAC PACEMAKERS INC(1)ARX JEFFREY ALLEN VON(1)CHAVAN ABHI(2)MAZAR SCOTT T(2)VON ARX JEFFREY A(2)BITTON GABRIEL(2)NAGAR RON(2)Bluetooth 8 02003-2012ABBOTT LAB(2)DEXCOM INC(2)YERUSHALMY ISRAEL(1)AWARE TECHNOLOGIES INC(1)CHRISTOPHER ELLEDGE(1)DOBBLES JOHN MICHAEL(2)KAMATH APURV U(2)MENSINGER MICHAEL ROBERT(2)YANG RICHARD C(2)RUPPERT DEBORAH M(1)
    • Page 27 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comMethods- Drug DeliveryMethods -DrugDeliveryTotalNo. ofRecordsAvg.No. ofFwdCitesperPatentsFilingYearRangeTop 5 Assignees Top 5 InventorsExternal 252 4.991989-2012MEDTRONIC INC(79)CARDIAC PACEMAKERS INC(28)MINIMED INC(5)INSULINE MEDICAL LTD(5)PHILIPS CORP(5)MIESEL KEITH A(13)HERUTH KENNETH T(10)GERBER MARTIN T(9)BARDY GUST H(7)DENISON TIMOTHY J(7)Internal 81 1.421994-2012MEDTRONIC INC(7)INSULINE MEDICAL LTD(4)BIOSENSE INC(3)GONNELLI ROBERT R(2)PACESETTER INC(2)GONNELLI ROBERT R(3)BITTON GABRIEL(3)NAGAR RON(3)PESACH BENNY(3)WEISS RAM(3)Programmable 59 8.811987-2012MEDTRONIC INC(16)MEDICAL RES GROUP(4)MINIMED INC(4)CHRONO THERAPEUTICS INC(3)NILIMEDIX LTD(2)LEBEL RONALD J(7)STARKWEATHER TIMOTHY J(6)WEISS PHILLIP T(6)SHAHMIRIAN VARAZ(5)VILLEGAS DANIEL H(5)Timed 19 7.681994-2012CHRONO THERAPEUTICS INC(2)BALL SEMICONDUCTOR INC(2)EV3 INC(1)STAAB ROBERT J(1)INT MEDICAL ASSOCIATES INC(1)DIPIERRO GUY(2)AHN SAMUEL S(2)AHN SUZANNE I(2)GAFFNEY F ANDREW(2)HAYS STEVEN R(2)
    • Page 28 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comMicropumpMicropumpTotalNo. ofRecordsAvg.No. ofFwdCitesperPatentsFilingYearRangeTop 5 Assignees Top 5 InventorsValve 85 4.261987-2012MEDTRONIC INC(5)HOSPIRA INC(4)MILUX HOLDING SA(4)BIOSENSE INC(3)SEARETE LLC(3)FORSELL PETER(6)GARVEY DAVID S(3)ECKHOFF PHILIP A(3)HYDE RODERICK A(3)ISHIKAWA MURIELY(3)Osmotic 61 0.741994-2011LUNAN PHARM GROUPCORP(7)BEIJING COSCI MED TECHCO LTD(3)EURO CELTIQUE SA(3)NEUROSYSTEC CORP(3)BIOSENSE INC(3)ZHIQUAN ZHAO(7)HAISONG JIANG(3)JINGANG WANG(3)OSHLACKBENJAMIN(3)WRIGHT CURTIS(3)Piezoelectric 29 5.381988-2012PRINCIPAL AB(3)BECTON DICKINSON & CO(3)BOEHRINGER INGELHEIMGMBH(2)CHRONO THERAPEUTICSINC(2)HARVEY NOEL G(2)SVEDMAN PAL(3)DOWN JAMES A(3)PETTIS RONALD J(3)DIPIERRO GUY(2)ALCHAS PAUL G(2)
    • Page 29 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comMicroneedleMicroneedleTotalNo. ofRecordsAvg.No. ofFwdCitesperPatentsFilingYearRangeTop 5 Assignees Top 5 InventorsHollow 96 6.911993-2012BECTON DICKINSON &CO(8)NOVO NORDISK AS(8)BIOSENSE INC(6)3M CO(5)ELAN CORP PLC(5)PETTIS RONALD J(8)RADMER JIM(5)GROSS JOSEPH(5)DOWN JAMES A(5)HARVEY NOEL G(5)Porous 34 1.51999-2012GEORGIA TECH RES INST(4)3M CO(3)GONNELLI ROBERT R(2)NOVO NORDISK AS(2)PALO ALTO RESEARCHCENTER INC(2)PRAUSNITZ MARK R(4)GONNELLI ROBERTR(3)DUAN DANIEL C(3)JOHNSON PETER R(3)BAI XU(2)Solid 30 4.231993-2012GEORGIA TECH RES INST(2)UNIV TSINGHUA(2)UNIV JILIN(2)BEIJING LINGRUI HIGHTECH CO LTD(1)SHANGHAI TAIYIN BIOLOGTECHNOLOGY CO LTD(1)RUIFENG YUE(2)YAN WANG(2)JINGYING ZHANG(2)MINJIE LI(2)XIAOAN ZHANG(2)StackedConfiguration7 4.712001-2011GONNELLI ROBERT R(2)REDEON INC(1)BIOVALVE TECHNOLOGIESINC(1)JANISYS LTD(1)UNGER EVAN C.(1)GONNELLI ROBERTR(3)ACKLEY DONALD E(1)NICKEL JANICE H(1)UNGER EVAN C(1)WU YUNQIU(1)
    • Page 30 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comLandscape for different methods used for drug deliveryThe contour map below represents different technologies in drug delivery with respect tocomplete patent portfolio. Clusters for treatment element and growth factor are close toeach other as there is high degree of relevance between the records present in thosetechnology areas. Whereas medicament delivery is represented as a different cluster as ithas less relevance with the other technologies present in the portfolio.Note: In the map above, records are placed based on their contextual similarity shared withneighboring records. Closer the clusters, more is the overlap or correlation between them.Each cluster or topic appears as either a shallow water area or land mass. Closely relatedtopics collate to form larger land masses having individual peaks based on those topics thathave maximum records. Labels for topics that are shared across various peaks appearbetween them.
    • Page 31 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comHow we did it?The categories created at the top level on methods for drug delivery were used as the base set forcreating technology landscapes. Each category was loaded into VizMAP and then contextually clustered(using Title and Abstract as the text) using the ‘Context Mode’ option to generate its technologylandscape. (The contour based thematic coloring option is automatically enabled in the Context mode inVizMAP.) We refined each of the generated map in two ways. We removed unrelated patents using the“Hide Unrelated records” option. In such maps unrelated records are those that do not share anysimilarity with any of the generated technology. Clusters appear usually in the blue ocean areas awayfrom the land parcels. Since they don’t have any significance for the map, and then can simply beremoved using the above mentioned option.
    • Page 32 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comUpcoming Companies: Focus on priority countries, filings andtechnology areasThe table below shows the research activity for the companies in different countries.How we did it?We researched online for some of the companies focusing on drug delivery technologies of which wegrouped companies present in our data set and filtered those within reports dashboard and using theAssignees tab identified respective priority countries.Note: Please refer Appendix B for patent details for these companiesCompaniesPriority CountriesUS FR CH IB EP JP IE IL AUALTEA THERPEAUTICS CORP 4ARDIGAM CORP 7ARTENGA ING 2CARDIOMEM INC 4CRISI MEDICAL SYSTEMS INC 2DEBIOTECH SA 2 1 1 2DEXCOM INC 11EKOS CORP 4 1ELAN CORP PLC 2 4FLUGEN INC 4HOSPIRA INC 8INTELLIJECT INC 2 1MEDINGO LTD 3 1MINIPUMPS LLC 5NEKTAR THERAPEUTICS 1NEUROSYSTECH CORP 4OREXO AB 1PSIVIDA INC 2RATIO INC 3SICEL TECHNOLOGIES INC 4SPECTRX INC 2STEADYMED LTD 1 2
    • Page 33 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comThe below matrix shows year wise filings for the companiesFiling YearTotal19931994199519961997199819992000200120022003200420052006200720082009201020112012CompaniesTotal 86 1 2 4 3 2 5 1 1 2 6 1 5 2 6 9 9 10 8 7 2Dexcom Inc 11 1 1 5 4Hospira Inc 8 1 2 1 1 2 1Aradigm Corp 7 3 1 2 1Elan Corp Plc 6 1 1 1 2 1Debiotech SA 6 1 1 1 1 1 1Minipumps Llc 5 2 2 1Ekos Corp 5 3 1 1SicelTechnologies Inc4 2 2NeurosystechCorp4 2 2Medingo Ltd 4 1 1 1 1Cardiomem Inc 4 2 2AlteaTheapeuticsCorp4 1 1 2Steadymed Ltd 3 1 1 1Ratio Inc 3 2 1Intelliject Inc 3 1 1 1Spectrx Inc 2 1 1Psivida Inc 2 1 1Crisi MedicalSystems Inc2 1 1Artenga Inc 2 1 1Orexo AB 1 1NektarTherapeutics1 1Flugen Inc 1 1
    • Page 34 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comHow we did it?Once upcoming companies were identified, we filtered records for those companies and moved those torespective user defined categories. In co‐occurrence analyzer, within Matrix Parameters, filing year wasselected and clusters were correlated with time and the resulting matrix was exported to Excel file.The contour below shows the field of research for the companies wherein most of theresearch activity is concentrated around pumps, microneedle and medical administration.Ekos Corp concentrates only on Ultrasound technology; it can be seen as a different clusteras it’s unrelated to other clusters.How we did it?The companies were loaded on the map using Analyze By option. They were then expanded on the basisof categories created and then contextually clustered (using Title, Abstract, Claims as the text) using the‘Context Mode’ option to generate its technology landscape. (The contour based thematic coloring optionis automatically enabled in the Context mode in VizMAP.) We removed unrelated patents using the “HideUnrelated records” option.
    • Page 35 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comUpcoming Company Portfolio spread across main IPCThe generated map below highlights activity assignees across top IPC.It can be seen that most of the companies have research activity across A61M.How we did it?We filtered records for the upcoming companies using the analyze option in Vizmap. These records werethen expanded by IPC to generate the above map.
    • Page 36 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comAppendix A: Search Strings Used for CategorizationCategorization: Sensors1. AmperometricAmperometric(TAC) contains (amperomet* w/5 sens*) 48 results2. Bio SensorsBio Sensors(TAC) contains ((bio* w/5 sens*) and not (biolog* or biopsy* biofouling orbiodegrad* or biomolecule* or biofeedback))51 results3. CalorimetricCalorimetric(TAC) contains (calorimet* w/5 sens*) 14 results4. Electro-OpticElectro-Optic(TAC) contains ((electro-optic* or electrooptic* or "electro optic*") w/5 sens*) 11 results5. FlowFlow(TAC) contains (flow* w/5 sens*) 145 results6. GlucoseGlucose(TAC) contains (glucose* w/5 sens*) 127 results7. ImpedanceImpedance(TAC) contains (impedance* w/5 sens*) 73 results8. Photo-ReflectivePhoto-Reflective(TAC) contains (photo* w/5 sens*) 55 results9. PressurePressure(TAC) contains (pressure* w/5 sens*) 431 results
    • Page 37 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com10. TemperatureTemperature(TAC) contains (temperature* w/5 sens*) 256 resultsCategorization: Microneedle1. HollowHollow(TAC) contains (hollow* w/5 (micro-needle* or microneedle* or "micro needle"or needle*))95 results2. PorousPorous(TAC) contains (porous w/5 (micro-needle* or microneedle* or "micro needle" orneedle*))34 results3. SolidSolid(TAC) contains (solid* w/5 (micro-needle* or microneedle* or "micro needle" orneedle*))30 results4. Stacked ConfigurationStacked Configuration(TAC) contains (Stacked* w/5 (micro-needle* or microneedle* or "micro needle"or needle*))7resultsCategorization: Micropump1. OsmoticOsmotic(TAC) contains (osmotic* w/5 (diuretic or dispenser* or dose* or dosage* orpump* or micropump* or "micro* pump*" or ((micro or mini) w/3 pump*) orminipump*) or ((electroosmotic or "electro osmotic") w/2 pump*) or "EOP" or"EO pump")61 results2. PiezoelectricPiezoelectric(TAC) contains ((piezoelectric* or piezo-electric* or piezo*) and (micropump* ormicro-pump* or "micro pump*" or minipunp* or "minp-pump*" or pump*))29 results3. ValveValve(TAC) contains ((valve*) w/5 (micropump* or micro-pump* or "micro pump*" orminipump or "mini*pump" pump*))85 results
    • Page 38 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comCategorization: Methods- Drug Delivery1. ExternalExternal(TAC) contains (external* w/5 ((drug* or pharma* or medic*) w/3 (inject* ordeliver* or infus* or diffus* or perfus* or releas* or syringe* or implant*)))252 results2. InternalInternal(TAC) contains (internal* w/5 ((drug* or pharma* or medic*) w/3 (inject* ordeliver* or infus* or diffus* or perfus* or releas* or syringe* or implant*)))81 results3. ProgrammableProgrammable(TAC) contains (programmable* w/5 ((drug* or pharma* or medic*) w/3 (inject*or deliver* or infus* or diffus* or perfus* or releas* or syringe* or implant*)))59 results4. TimedTimed(TAC) contains (timed* w/5 ((drug* or pharma* or medic*) w/3 (inject* ordeliver* or infus* or diffus* or perfus* or releas* or syringe* or implant*)))19 resultsCategorization: Communication1. BluetoothBluetooth(TAC) contains ((bluetooth* or “blue-tooth”) w/5 communicat*) 8 results2. OpticalOptical(TAC) contains ("optical*" w/5 communicat*) 25 results3. Radio FrequencyRadio Frequency(TAC) contains (("radio frequency" or RF or "radio-frequency*") w/5communicat*)47 results4. WirelessWireless(TAC) contains (wireless* w/5 communicat*) 190 results
    • Page 39 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comCategorization: Applications1. AtherosclerosisAtherosclerosis(TAC) contains (atherosclerosis* and ((drug* or pharma* or medic*) w/3 (inject*or deliver* or infuse* or diffuse* or perfuse* or releas* or syringe* or implant*))) 26 results2. Blood InfectionBlood Infection(TAC) contains (blood and infect*) and ((drug* or pharma* or medic*) w/3(inject* or deliver* or infuse* or diffuse* or perfuse* or releas* or syringe* orimplant*))92 results3. CancerCancer(TAC) contains (cancer* or (malignant w/3 neoplasm) or Hyperplasia or Cyst orPseudocyst or Hamartoma or Dysplasia or "Carcinoma in situ" or Metastasis) and((drug* or pharma* or medic*) w/3 (inject* or deliver* or infuse* or diffuse* orperfuse* or releas* or syringe* or implant*))221 results4. CardiacCardiac(TAC) contains ((cardiac* and heart) and ((drug* or pharma* or medic*) w/3(inject* or deliver* or infuse* or diffuse* or perfuse* or releas* or syringe* orimplant*)))175 results5. Coronary Artery DiseaseCoronary Artery Disease(TAC) contains ((coronary* w/5 arter*) or myocardium* or "cardiac vein*" orischemia or tricuspid or mitral or systole) and ((drug* or pharma* or medic*)w/3 (inject* or deliver* or infuse* or diffuse* or perfuse* or releas* or syringe* orimplant*))105 results6. Dermal DisorderDermal Disorder(TAC) contains (dermal* or Fibroblasts* or Macrophages* or Adipocyte* ordermis* or corium) and ((drug* or pharma* or medic*) w/3 (inject* or deliver* orinfuse* or diffuse* or perfuse* or releas* or syringe* or implant*))127 results7. DiabetesDiabetes(TAC) contains (mellitus or diabetes or (insulin w/3 pump) or "NIDDM" or "IDDM"or polyuria or polydipsia or polydipsia or Kussmaul) and ((drug* or pharma* or157 results
    • Page 40 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.commedic*) w/3 (inject* or deliver* or infuse* or diffuse* or perfuse* or releas* orsyringe* or implant*))8. HypertensionHypertension(TAC) contains (hypertension or (high w/3 pressure) or (arterial w/3hypertension)) and ((drug* or pharma* or medic*) w/3 (inject* or deliver* orinfuse* or diffuse* or perfuse* or releas* or syringe* or implant*))120 results9. MuscleMuscle(TAC) contains (muscle* and ((drug* or pharma* or medic*) w/3 (inject* ordeliver* or infuse* or diffuse* or perfuse* or releas* or syringe* or implant*)))213 results10. NeurologicalNeurological(TAC) contains (neurologic* w/5 ((drug* or pharma* or medic*) w/3 (inject* ordeliver* or infuse* or diffuse* or perfuse* or releas* or syringe* or implant*)))5 results11. Peripheral Vascular DiseasePeripherical Vascular Disease(TAC) contains (vascular* w/5 disease*) and ((drug* or pharma* or medic*) w/3(inject* or deliver* or infuse* or diffuse* or perfuse* or releas* or syringe* orimplant*))31 results12. SkinSkin(TAC) contains "skin" and ((drug* or pharma* or medic*) w/3 (inject* or deliver*or infuse* or diffuse* or perfuse* or releas* or syringe* or implant*))518 results13. Traversing Alimentary TractTraversing Alimentary Tract(TAC) contains (traversing* w/3 alimentary*) and ((drug* or pharma* or medic*)w/3 (inject* or deliver* or infuse* or diffuse* or perfuse* or releas* or syringe* orimplant*))2 results14. VaccinationVaccination(TAC) contains (vaccinat*) and ((drug* or pharma* or medic*) w/3 (inject* ordeliver* or infuse* or diffuse* or perfuse* or releas* or syringe* or implant*))9 results
    • Page 41 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comAppendix B: List of Patents for Upcoming Companies in thistechnologyPatent Number Title Assignees Filing Date AbstractAU2001279072Closed-loop flowcontrol for IV fluiddeliveryHOSPIRA INC 27/Jul/2001In a closed-loop process, a controller uses a flowsensor to monitor the flow of a medicinal fluidbeing infused into a patient, to achieve a desiredrate of flow. A relatively inexpensive peristalticpump or electronically controlled valve can beused to vary the flow of the medicinal fluidthrough a fluid line. A Y site within the fluid lineincludes an integral flow sensor having anorifice. The flow sensor includes proximal anddistal pressure sensors disposed on oppositesides of the orifice to monitor the distal andproximal pressure, producing a signal indicativeof the rate of flow of the medicinal fluid throughthe fluid line. A signal produced by the controlleris input to a motor driving the pump or to thevalve to vary the rate of flow as required toachieve the desired infusion rate of themedicinal fluid. [WO0209795A2]AU2002248586Disposable infusioncassette with low airbubble retention andimproved valvesHOSPIRA INC 11/Mar/2002A disposable cassette for use with a medicalinfusion pump. An elastomeric membrane iscaptured between a facing member and a baseof the cassette and is displaced into a pumpingchamber. The elastomeric membrane includes agenerally T-shaped lip, and correspondinggrooves are provided on the facing member andbase. As the cassette is assembled, aninterference fit between the lip and the groovescauses the membrane to stretch taut and to besecurely anchored, eliminating a break-in periodwhen the cassette is initially used. "Lobes" ofincreased thickness provided on theundersurface of a portion of the elastomericmembrane overlying the pumping chamberreduce the residual volume of the pumpingchamber, thereby reducing the volume of airretained within the chamber and increasing theaccuracy of the cassette. The lobes also sweepair bubbles from the sides of the pumpingchamber during operation, further reducing airbubbles retained in the pumping chamber. Adistal tube support retains a distal fluid linebetween air or pressure sensors included on apump drive mechanism, thus reducing thelikelihood of sensing errors. Inlet and outletvalve flaps and corresponding seating surfacesincluded in the base are configured to providequieter operation, further reduce the residualvolume of the pumping chamber, increase fluidvelocity through the outlet valve to sweep airbubbles from the pumping chamber, and protectagainst a "blown" inlet valve. [US2002159900A1]
    • Page 42 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comAU2002361897PULMONARYDELIVERY OFAMINOGLYCOSIDESNEKTARTHERAPEUTICS19/Dec/2002The present invention is directed to theadministration of aminoglycosides. In particular,the present invention is directed tocompositions and methods for the pulmonaryadministration of aminoglycosides. According toa preferred embodiment, compositions andmethods are provided for the localizedtreatment of respiratory infections.[WO03053411A1]AU2004201488Fluid management ina continuous fluidcollection and sensordeviceALTEATHERAPEUTICSCORP,SPECTRXINC07/Apr/2004 NoneAU2004214420In vivo fluorescencesensors, systems, andrelated methodsoperating inconjunction withfluorescent analytesSICELTECHNOLOGIESINC17/Feb/2004Methods, systems, devices and computerprogram product include: (i) administering afluorescent analyte to a subject; (ii) repetitivelyemitting excitation light from an implantedsensor over a desired monitoring period; (iii)detecting fluorescence intensity in response tothe excitation light using the implanted sensorthat outputs the excitation light; and (iv) usingdata associated with the detected fluorescenceintensity to perform at least one of: (a) calculatethe concentration or dose of the analytereceived proximate to the implanted sensor site;(b) evaluate the pharmacodynamic orpharmacokinetic activity of the fluorescentanalyte; (c) confirm Ab attachment to a tumorsite; (d) monitor a non-target site to confirm it isnot unduly affected by a therapy; (e) monitor forchanges in cellular properties; (f) use thecalculated dose or concentration data to adjustor customize a therapeutic amount of theanalyte administered to the subject; (g) confirmmicelle concentration at a target site and thenstimulate toxin release based on theconfirmation; and (h) monitor for the expressionof a protein produced from a gene therapymodification. In particular embodiments, theintensity of the excitation signals emitted to thelocalized tissue can be varied in a predeterminedmanner to generate optical profiling data of theresponse of the tissue proximate the sensor.[WO2004075032A2]AU2004284914Method fortransdermal deliveryof permeantsubstancesALTEATHERAPEUTICSCORP21/Oct/2004A method for delivering permeant substancestransdermally into a membrane of an animalincludes forming at least one delivery opening inthe skin tissue, with the at least one deliveryopening having a mean opening depth ofbetween about 40 and about 90 microns.[US2005090800A1]
    • Page 43 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comAU2006262233Method andapparatus fordelivering animplantable wirelesssensor for in vivopressuremeasurementCARDIOMEMSINC21/Jun/2006An apparatus for implanting an implant devicehaving a corkscrew-type anchor associatedtherewith into a patient includes an elongated,flexible shaft. A retention mechanism is locatedat the distal end of the shaft for retaining thedevice at the distal end of the shaft. Theapparatus includes means selectively operablefor disengaging the retention mechanism fromthe implant device when the anchor has beenanchored into tissue at a target site. In anotheraspect, an apparatus for releasing an implantinto a vessel within a patient includes anelongated shaft for inserting into the vessel ofthe patient. A tether wire extends through theproximal portion of a secondary lumen, exits afirst port, engages a portion of the implant,enters a second port, and extends through atleast a portion of a distal portion of thesecondary lumen. The implant is therebytethered to the side of the elongated shaft, andpulling the tether wire disengages the tetherwire from the distal portion of the secondarylumen and the implant so as to release theimplant from the shaft. [WO2007002224A2]AU2006262234Implantable wirelesssensor for in vivopressuremeasurementCARDIOMEMSINC21/Jun/2006A sensor suitable for in vivo implantation has acapacitive circuit and a three-dimensionalinductor coil connected to the capacitive circuitto form an LC circuit. The LC circuit ishermetically encapsulated within an electricallyinsulating housing. An electrical characteristic ofthe LC circuit is responsive to a change in anenvironmental parameter. [US2006287602A1]AU2007248475Implantable wirelesssensor for in vivopressuremeasurement andcontinuous outputdeterminationCARDIOMEMSINC04/May/2007A method and apparatus for determining cardiacparameters within the body of a patient includesa wireless sensor positioned in the patientspulmonary artery. An external RF telemetrydevice communicates wirelessly with the sensorand interrogates the sensor to determinechanges in pressure in the pulmonary arteryover time. The peak pressure difference isdetermined. Then, assuming zero blood flowvelocity at the time of valve opening and at thetime of valve closing, a velocity-time function isdetermined. The velocity-time function is usedto determine a velocity-time integral. Thevelocity-time integral is then used to determinecardiac stroke volume. The cardiac strokevolume is multiplied times the heartbeat rate todetermine cardiac output. The cardiac outputcan be monitored over time to determinecontinuous cardiac output. [WO2007130628A2]AU2007270770Medical device foradministering asolutionDEBIOTECH SA 18/Jun/2007The device has a communication unit allowingcommunication between a reservoir and apumping unit, where the reservoir containsmedical solution i.e. insulin, and a patient lineadapted for connecting the device to a patient. Adetermination unit determines physico-chemicalcharacteristics e.g. evaporation characteristics,of the solution based on time by using amathematical model. A variation unit varies theadministration of the solution based on avariation of concentration of the determined
    • Page 44 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comsolution. [EP1875933A1]AU2007286645System and methodfor improved lowflow medical pumpdeliveryHOSPIRA INC 23/Aug/2007A medical pump with an improved continuitylow flow delivery system and method for usewith a pumping chamber, for example in acassette, is disclosed. The pump includes a pumpdrive for exerting a force on the pumpingchamber and a sensor for sensing theforce/pressure exerted by the pump drive on thepumping chamber. The pump drive positionsensor senses the position of the pump drive.The medical pump also includes a processingunit and a memory having a programming codeadapted to calculate the rate of change of thesensed force/pressure values and determinewhether the rate of change of the sensedforce/pressure values meets a rate of changethreshold. Once the rate of change threshold ismet, the programming code is adapted tocalculate a remaining pump drive travel value fordetermining how much farther the pump driveshould travel before the end of an effectivepump cycle. The programming code is furtheradapted to trigger one or more signals to drivethe pump drive for the remainder of theeffective pump cycle using the remaining pumpdrive travel value. [US2007058412A1]AU2007294526Physiological dataacquisition andmanagement systemfor use with animplanted wirelesssensorCARDIOMEMSINC10/Sep/2007Aspects and embodiments of the presentinvention provide a system for obtaining,processing and managing data from animplanted sensor. In some embodiments, apatient or other persons can use a flexibleantenna to obtain data from the implantedsensor. The flexible antenna includes at leastone transmit loop and at least one receive loop.The transmit loop is adapted to propagateenergizing signals to the implanted sensor. Thereceive loop is adapted to detect a responsesignal from the implanted sensor. The transmitloop includes a capacitor formed by adiscontinuous area. The capacitor is adapted toallow the loop to be tuned. The flexible antennacan communicate with a patient device thatcollects the data from the implanted sensor,creates a data file and transmits the data file to aremote server over a network. A physician orother authorized person may access the remoteserver using an access device.[WO2008031095A1]AU2008227836User interface forselecting bolus dosesin a drug deliverydeviceMEDINGO LTD 19/Mar/2008An apparatus and system for selecting a bolusdose of a drug in a drug delivery device isdisclosed. A bolus dose is selected from a pre-determined schedule of bolus doses, whereineach dose corresponds to a range of a bodyanalyte levels. [WO2008114254A1]
    • Page 45 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comAU2009311600Fluid medicationdelivery systems fordelivery monitoringof secondarymedicationsHOSPIRA INC 10/Jun/2009A fluid medication delivery system comprises aprimary medication reservoir, a secondarymedication reservoir, an infusion pump, a firstvalve assembly, a second valve assembly, a firsty-site, and a fluid flow sensor assembly. Theprimary medication reservoir has a first fluid.The secondary medication reservoir has asecond fluid. The infusion pump pumps fluidfrom at least one of the primary medicationreservoir and the secondary medicationreservoir. The first valve assembly controls theflow of fluid from the primary medicationreservoir in a first fluid line segment. The secondvalve assembly controls the flow of fluid fromthe secondary medication reservoir in a secondfluid line segment. The fluid flow sensorassembly determines the flow rate of a fluidfrom the secondary medication reservoir in thesecond fluid line segment. [US2010114027A1]AU2010231527Devices and methodsfor enhancing drugabsorption rateMEDINGO LTD 06/Apr/2010Devices, systems and methods directed to a drugdelivery device including a soft subcutaneouslyinsertable cannula are disclosed. Someembodiments of the cannula include anelongated soft tube having a plurality ofapertures spaced around and/or along a wall ofthe elongated soft tube. The plurality ofapertures is configured for fluid flowtherethrough resulting-in/causing an increase inan absorption rate of the fluid in the body of theuser. The drug delivery device can be an insulinpump.AU2010246067Porous silicon drug-eluting particlesPSIVIDA INC 04/May/2010The invention provides a biodegradable drug-eluting particle useful for the delivery ofdiagnostic or therapeutic agents. In certainembodiments, the drug-eluting particle of theinvention comprises a biodegradable poroussilicon body, a reservoir formed within theporous silicon body having at least one openingto an exterior of the body, wherein the reservoircontains a therapeutic or diagnostic agent, andan agent- permeable seal disposed over the atleast one opening. The invention furtherprovides a method for treating a patient toobtain a desired local or systemic physiologicalor pharmacological effect comprisingadministering a sustained release drug deliveryparticle of the invention. The invention alsoprovides methods of fabricating a drug- elutingparticle for releasing therapeutic agents.AU2010284216Electrolytic drug-delivery pump withadaptive controlMINIPUMPS LLC 18/Aug/2010Actuation of a drug-delivery pump is controlledbased on a change in a condition of the pump.
    • Page 46 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comAU2011203724 Drug delivery deviceFLUGENINC,RATIO INC04/Jan/2011A drug delivery device for delivering a drug to asubject includes a microneedle configured tofacilitate delivery of the drug to the subject. Themicroneedle includes a tip portion and ismoveable from an inactive position to anactivated position. When the microneedle ismoved to the activated position, the tip portionof the microneedle is configured to penetratethe skin of the subject to provide drug deliveryinto the skin of the subject.AU2012201481Devices, systems,and methods formedicament deliveryINTELLIJECT INC 13/Mar/2012Certain exemplary embodimets can comprise anauto-injector (1000), which can comprise: a vial(4300) configured to store and/or contain aninjectable medicament, the vial defining a viallongitudinal axis, and a housing (1800)comprising the vial. In various embodiments, theinjectable medicament can be a medicine,medication, drug, pharmaceutical, prescriptive,agent, antidote, anti-veno hormone, stimulant,vasodilator, anesthetic, and/or nutritionalsupplement that is substantially ready forinjection.AU685694Creating anaerosolizedformulation of insulinARADIGM CORP 27/Oct/1995Devices, packaging and methodology forefficiently and repeatably creating aerosolizedbursts of an insulin containing formulation aredisclosed. Devices are hand-held, self-containedunits which are automatically actuated at thesame release point in a patients inspiratory flowcycle. The release point is automaticallydetermined either mechanically or, morepreferably calculated by a microprocessor whichreceives data from a sensor making it possible todetermine inspiratory flow rate and inspiratoryvolume. Actuation of the device forces insulinformulation through a porous membrane (3) ofthe container (1) which membrane has poreshaving a diameter in the range of about 0.25 to3.0 microns, preferably 0.25 to 1.5 microns.[WO9613161A1]AU693279Analyte-controlledliquid delivery deviceand analyte monitorELAN CORP PLC 27/Oct/1995A liquid delivery device (40) comprising ahousing (41) having a lower surface (51) forapplication to the skin of a subject and having areservoir (42) and a gas generation chamber (43)therein separated by a displaceable membrane(45). Gas generated by an electrolytic cell (44)under the control of a microprocessor (46)causes the gas generation chamber (43) toexpand and the reservoir (42) to contract,thereby discharging a liquid drug, such as insulin,from the reservoir via a hollow delivery needle(49) extending from the lower surface (51). Thedelivery needle (49) and a sensor needle (48)both extend from the lower surface a sufficientdistance so as to penetrate through theepidermis and into the dermis when the housingis pressed against the skin. The sensor needle(48) has an enzymatic coating for the detectionof an analyte, such as glucose in the subjectsplasma. The delivery needle (49) is made ofplatinum-iridium, and a current passes betweenthe needles (48, 49) and a potentiostat circuit(47) according to the amount of glucosedetected. A reference electrode (silver/silver
    • Page 47 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comchloride) (50) which rests against the subjectsskin increases the accuracy of the glucosemeasurement. The current through thepotentiostat circuit (47) is measured by avoltmeter (53) and a signal from the voltmeter(53) is amplified and communicated to themicroprocessor (46) which determines thecorrect rate of delivery of the drug on the basisof the level of analyte detected in the subjectsplasma. [WO9614026A1]AU734896Medical device forinjecting liquidDEBIOTECH SA 18/Dec/1997The invention concerns a device for injectingliquid comprising a connection piece on which islocated at least a first liquid occlusion system(7). The invention is characterised in that aregulating system (4) is located upstream of thefirst occlusion system, the two systems definingan intermediate segment in which the pressure,in the absence of injection, is higher than thepressure prevailing downstream of the firstocclusion system for directing downstream anyleak at the first occlusion system. The inventionis applicable to a pump used for injectingcontrast liquid for medical imaging.[FR2757069A1]AU741913Device foradministering insulinin controlled dosagesby controlling totalinhaled volumeARADIGM CORP 23/Apr/1998Dosages of inhaled insulin are controlled withina narrow range by controlling the total volumeof air inhaled by a patient. By repeatedlydelivering aerosolized insulin with the same totalinhaled volume of air, the amount of insulindelivered to the patient each time is consistent.A device (40) comprises a means (11, 29) formeasuring inhaled volume and for haltinginhalation at a predetermined point. The devicealso comprises an adjustable means (9) forapplying various amounts of force to a container(1) of formulation (5) to expel different amountsof drugs from the container based on the forceapplied. [WO9848873A1]AU770388Fluid management ina continuous fluidcollection and sensordeviceALTEATHERAPEUTICSCORP,SPECTRXINC20/Jul/1999A fluid collection and sensor device forplacement over at least one artificial openingmade in a biological membrane for measuring acharacteristic of a biological fluid collected fromthe tissue through the at least one artificialopening. The device comprises a sensor (110)positioned in a flow path (105) of the biologicalfluid for contacting a quantity of the biologicalfluid and generating an indication of acharacteristic of the biological fluid. According toone aspect of the invention, a waste fluidstorage element (120), such as a reservoir, ispositioned in the device (100) to collect thebiological fluid after it has made contact with thesensor (110). According to another aspect of theinvention, various surfaces of the fluid flow path(105) of the fluid collection and sensor device(100) are treated with an agent to limit orminimize clotting, aggregation or sepsis of thebiological fluid, blockage or clogging of the flowpath (105) or degradation of the sensor (110).According to still another aspect of theinvention, various configurations of a fluidsensor and collection device (100) are providedthat are designed to ensure that measurements
    • Page 48 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comare made on independent fluid samples.[WO0004821A1]AU780752Apparatus formicroporation ofbiologicalmembranes usingthin film tissueinterface devices,and method thereforALTEATHERAPEUTICSCORP08/Jun/2000The invention provides for improved devices andmethods for forming openings in a biologicalmembrane for delivering substances into ananimal through the biological membrane fortreatment applications, or extracting substancesfrom the animal through the biologicalmembrane for monitoring or other diagnosisapplications and for increased transmembraneflux. [WO0074767A2]CA2577457MICROBUBBLEMEDICAL DEVICESARTENGA INC 06/Feb/2007Method and medical devices for generating andstabilizing micro or nano bubbles, and systemsand methods for therapeutic applications usingthe bubbles, is provided. Two novel bubblegenerating means are provided: in-line capillarytubes and mix chambers flow focusing, and crossflow bubble generation with optimized bubb ledetachment means. A method and medicaldevice to stabilize bubble sizes and improvebubble size homogeneity through rectifieddiffusion is disclosed. A method and system tofacilitate acoustic activation of therapeuticagents using ultrasound energy is provided.Methods, systems, selected additives, anddevices to permit therapeutic benefits such asultrasound-guided precision drug delivery andreal-time verification, acoustic activation of largetumour masses while avoiding acousticshadowing, enhance d acoustic activationthrough longer retention of therapeutic agentsat the point of interest, on demand means tocombine inertial and non-inertial acousticactivation in a single treatment, enhancement ofhigh intensity focused ultrasound treatment s,light activation of photodynamic drugs at adepth within a patient using extracorporeal lightsources, probes, or sonoluminescence, andinitiation of time reversal acoustics focusedultrasound to permit highly localized treatment,are provided.</SDOA B>CA2657380DEVICES, SYSTEMSAND METHODS FOROPHTHALMIC DRUGDELIVERYNEUROSYSTECCORP20/Jul/2007Devices, systems and techniques for deliveringdrugs to an ocular tissue are described. In atleast some embodiments, a terminal component(e.g., a n eedle or open end of a catheter) isimplanted in an ocular tissue and used t o deliverone or more drugs. The delivered drugs maycome from a source whic h is also implanted, ormay be introduced from an external source (e.g.,via a port). Both solid and liquid drugformulations can be used. Ocular implan ts canalternatively include a thin film coating thatreleases a drug into a n ocular tissue.CN101528283Apparatus andmethod fordeliveringtherapeutic and/orother agents to theinner ear and toother tissuesNEUROSYSTECCORP24/Jan/2006The present invention discloses an apparatusmay include a needle for sustained delivery ofdrugs and other agents to the inner ear or othertissues of a human or an animal. The needle caninclude an insertion stop, and can be placedthrough the round window membrane orthrough a surgically-prepared hole in a bone.The needle can be in fluid communication with aport and/or with a micro-infusion or osmoticpump. A cochlear implant electrode can be used
    • Page 49 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.cominstead of a needle.EP1381395SYSTEMS, METHODSAND DEVICES FOR INVIVO MONITORINGOF A LOCALIZEDRESPONSE VIA ARADIOLABELEDANALYTE IN ASUBJECTSICELTECHNOLOGIESINC23/Apr/2002Methods, systems, devices and computerprogram products monitor in vivo detectedradiation in a target localized site within asubject, over a selected time period, to do oneor more of: (a) quantify a radiation dosereceived at a local site; (b) assessbioreceptiveness to a particular treatment timeor type; (c) evaluate the pharmacokinetics of aradiolabeled analyte corresponding to a non-radiolabeled analyte; (d) monitor or evaluatemetabolic activity; or (e) evaluate a tumor priorto or after a therapeutic treatment.[WO02086449A2]EP1695734Microneedles forminimally invasivedrug delivery or fordiagnostic samplingHOSPIRA INC 22/May/2002The present invention provides a microneedleincorporating a base that is broad relative to aheight of the microneedle, to minimizebreakage. The microneedle further includes afluid channel and a beveled non?coringtip. Preferably arrays of such microneedles arefabricated utilizing conventional semiconductorderived micro?scale fabricationtechniques. A dot pattern mask is formed on anupper surface of a silicon substrate, with eachorifice of the dot pattern mask corresponding toa desired location of a microneedle. Orifices areformed that pass completely through thesubstrate by etching. A nitride pattern mask isformed to mask all areas in which a nitride layeris not desired. A nitride layer is then depositedon the bottom of the silicon substrate, on thewalls of the orifice, and on the top of the siliconsubstrate around the periphery of the orifice.The nitride layer around the periphery of theorifice is offset somewhat, such that one side ofthe orifice has a larger nitride layer. Anisotropicetching is used to remove a substantial portionof the substrate, creating a plurality of angular,blunt, and generally pyramidal-shapedmicroneedles. A subsequent removal of thenitride layer, followed by an isotropic etchingstep, softens and rounds out the blunt angularmicroneedles, providing generally conical-shaped microneedles. The uneven nitride layeradjacent the orifice ensures that themicroneedles will include a beveled tip. Suchmicroneedle arrays are preferably incorporatedinto handheld diagnostic and drug deliverysystems. [WO02100474A2]EP1861161APPARATUS ANDMETHOD FORDELIVERINGTHERAPEUTICAND/OR OTHERAGENTS TO THEINNER EAR AND TOOTHER TISSUESNEUROSYSTECCORP24/Jan/2006An apparatus may include a needle for sustaineddelivery of drugs and other agents to the innerear or other tissues of a human or an animal.The needle can include an insertion stop, andcan be placed through the round windowmembrane or through a surgically-prepared holein a bone. The needle can be in fluidcommunication with a port and/or with a micro-infusion or osmotic pump. A cochlear implantelectrode can be used instead of a needle.[US2006264897A1]
    • Page 50 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comEP2058020Devices formedicament deliveryINTELLIJECT INC 01/Feb/2006An apparatus (1000) comprising: a housing(1100); a medicament delivery mechanismconfigured to be disposed within the housing;and an electronic circuit system configured tobe coupled to the housing, the electronic circuitsystem further configured to produce an output.[EP2058020A2]EP2152350INTEGRATEDMEDICAMENTDELIVERY DEVICEFOR USE WITHCONTINUOUSANALYTE SENSORDEXCOM INC 05/Jun/2008An integrated system for the monitoring andtreating diabetes is provided, including anintegrated receiver/hand-held medicamentinjection pen, including electronics, for use witha continuous glucose sensor. In someembodiments, the receiver is configured toreceive continuous glucose sensor data, tocalculate a medicament therapy (e.g., via theintegrated system electronics) and toautomatically set a bolus dose of the integratedhand-held medicament injection pen, wherebythe user can manually inject the bolus dose ofmedicament into the host. In someembodiments, the integrated receiver and hand-held medicament injection pen are integrallyformed, while in other embodiments they aredetachably connected and communicated viamutually engaging electrical contacts and/or viawireless communication. [US2008306434A1]EP2232216DIFFERENTIALPRESSURE BASEDFLOW SENSORASSEMBLY FORMEDICATIONDELIVERYMONITORING ANDMETHOD OF USINGTHE SAMEHOSPIRA INC 17/Dec/2008A differential pressure based flow sensorassembly and method of using the same todetermine the rate of fluid flow in a fluid system.The sensor assembly comprises a disposableportion, and a reusable portion. A flowrestricting element is positioned along a fluidflow passage between an inlet and an outlet.The disposable portion further has an upstreamfluid pressure membrane and a downstreamfluid pressure membrane. The reusable portionhas an upstream fluid pressure sensor and adownstream fluid pressure sensor. Theupstream fluid pressure sensor senses theupstream fluid pressure at a location within thefluid flow passage between the inlet and theflow restricting element. The downstream fluidpressure sensor senses the downstream fluidpressure at a location within the fluid flowpassage between the flow restricting elementand the outlet. The process utilizes output of thesensors to calculate the flow rate of the fluid.[US2009157040A1]EP2252196SYSTEMS ANDMETHODS FORPROCESSING,TRANSMITTING ANDDISPLAYING SENSORDATADEXCOM INC 20/Feb/2009Systems and methods for continuousmeasurement of an analyte in a host areprovided. The system generally includes acontinuous analyte sensor configured tocontinuously measure a concentration of analytein a host and a sensor electronics modulephysically connected to the continuous analytesensor during sensor use, wherein the sensorelectronics module is further configured todirectly wirelessly communicate displayablesensor information to a plurality of differenttypes of display devices. [WO2009105709A1]
    • Page 51 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comEP2496283MEDICATIONINJECTION SITE ANDDATA COLLECTIONSYSTEMCRISI MEDICALSYSTEMS INC03/Nov/2010A medication delivery apparatus for use with amedication container includes a housing, a fluidconduit at least partially extending within thehousing and configured to deliver medicationwithin the medication container to a patient, amedication port extending from the housing andconfigured to be coupled to a fluid outlet of themedication container, the medication port beingfluidically coupled to the fluid conduit, and atleast one sensor disposed within the housing togenerate information characterizingadministration of the medication for processingby a remote data collection system. The housingcan have a size and shape that enables it to besupported by a first hand of a user while theuser administers the medication from themedication container via the medication portusing a second hand of the user. Relatedapparatus, systems, kits, and techniques are alsodescribed. [WO2011056888A2]US20040199059Optimized sensorgeometry for animplantable glucosesensorDEXCOM INC 22/Aug/2003An implantable sensor for use in measuring aconcentration of an analyte such as glucose in abodily fluid, including a body with a sensingregion adapted for transport of analytesbetween the sensor and the bodily fluid,wherein the sensing region is located on acurved portion of the body such that when aforeign body capsule forms around the sensor, acontractile force is exerted by the foreign bodycapsule toward the sensing region. The body ispartially or entirely curved, partially or entirelycovered with an anchoring material forsupporting tissue ingrowth, and designed forsubcutaneous tissue implantation. Thegeometric design, including curvature, shape,and other factors minimize chronic inflammatoryresponse at the sensing region and contribute toimproved performance of the sensor in vivo.US20080107720Topical delivery ofcodrugsPSIVIDA INC 04/Jan/2008The present invention provides pharmaceuticalcompositions for topical delivery comprising asuitable carrier and a codrug capable ofpenetrating, or being transported across, thedermis. The codrug according to the inventioncomprises a first constituent moiety linked to asecond constituent moiety, wherein the secondconstituent moiety is the same as, or differentfrom, the first constituent moiety. The first andsecond constituent moieties are so linked thatthey are easily transported into or across thedermis, into the skin, or into the blood orlymphatic system, and are reconstituted in vivoto form the first and second constituentmoieties.US20080195232BIOINTERFACE WITHMACRO- ANDMICRO-ARCHITECTUREDEXCOM INC 15/Apr/2008Disclosed herein are biointerface membranesincluding a macro-architecture and a micro-architecture co-continuous with and bonded toand/or located within at least a portion of themacro-architecture. The macro- and micro-architectures work together to manage andmanipulate the high-level tissue organizationand the low-level cellular organization of theforeign body response in vivo, therebyincreasing neovascularization close to a device-
    • Page 52 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comtissue interface, interfering with barrier cell layerformation, and providing good tissue anchoring,while reducing the effects of motion artifact, anddisrupting the organization and/or contractureof the FBC. The biointerface membranes of thepreferred embodiments can be utilized withimplantable devices such as devices for thedetection of analyte concentrations in abiological sample (for example, from a body),cell transplantation devices, drug deliverydevices, electrical signal delivering or measuringdevices, and/or combinations thereof.US20080287765INTEGRATEDRECEIVER FORCONTINUOUSANALYTE SENSORDEXCOM INC 29/Jul/2008A system is provided for monitoring glucose in ahost, including a continuous glucose sensor thatproduces a data stream indicative of a hostsglucose concentration and an integratedreceiver that receives the data stream from thecontinuous glucose sensor and calibrates thedata stream using a single point glucose monitorthat is integral with the integrated receiver. Theintegrated receiver obtains a glucose value fromthe single point glucose monitor, calibrates thesensor data stream received from thecontinuous glucose sensor, and displays one orboth of the single point glucose measurementvalues and the calibrated continuous glucosesensor values on the user interface.US20090192366SYSTEMS ANDMETHODS FORPROCESSING SENSORDATADEXCOM INC 24/Oct/2008Systems and methods for processing sensor dataare provided. In some embodiments, systemsand methods are provided for calibration of acontinuous analyte sensor. In someembodiments, systems and methods areprovided for classification of a level of noise on asensor signal. In some embodiments, systemsand methods are provided for determining arate of change for analyte concentration basedon a continuous sensor signal. In someembodiments, systems and methods for alertingor alarming a patient based on prediction ofglucose concentration are provided.US20090192380SYSTEMS ANDMETHODS FORPROCESSING SENSORDATADEXCOM INC 24/Oct/2008Systems and methods for processing sensor dataare provided. In some embodiments, systemsand methods are provided for calibration of acontinuous analyte sensor. In someembodiments, systems and methods areprovided for classification of a level of noise on asensor signal. In some embodiments, systemsand methods are provided for determining arate of change for analyte concentration basedon a continuous sensor signal. In someembodiments, systems and methods for alertingor alarming a patient based on prediction ofglucose concentration are provided.US20090203981SIGNAL PROCESSINGFOR CONTINUOUSANALYTE SENSORDEXCOM INC 15/Apr/2009Systems and methods for dynamically andintelligently estimating analyte data from acontinuous analyte sensor, including receiving adata stream, selecting one of a plurality ofalgorithms, and employing the selectedalgorithm to estimate analyte values. Additionaldata processing includes evaluating the selectedestimative algorithms, analyzing a variation ofthe estimated analyte values based on statistical,clinical, or physiological parameters, comparing
    • Page 53 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comthe estimated analyte values with correspondingmeasure analyte values, and providing output toa user. Estimation can be used to compensatefor time lag, match sensor data withcorresponding reference data, warn of upcomingclinical risk, replace erroneous sensor datasignals, and provide more timely analyteinformation encourage proactive behavior andpreempt clinical risk.US20090299156CONTINUOUSMEDICAMENTSENSOR SYSTEM FORIN VIVO USEDEXCOM INC 04/Feb/2009Systems and methods for continuousmeasurement of a medicament in vivo areprovided. In some embodiments, the system isconfigured to provide information associatedwith medicament titration and includes acontinuous analyte sensor and a communicationdevice. In some embodiments, the system isconfigured for continuous ambulatory drugtesting, including an ambulatory host monitorhaving a continuous sensor, a location module, aprocessor module and a transmitter. In someembodiments, the system is configured forcontinuously monitoring a hormone level andincludes a continuous hormone sensor and acommunication device configured to outputhormone information in real time. Yet anotherembodiment provides an analyte sensor forcontinuous monitoring of a hosts nutritionalstatus, and is configured for both continuousglucose detection and continuous albumindetection.US20100022992 Drug Delivery Device STEADYMED LTD 06/May/2007The present application provides a drug-deliverydevice comprising a drug reservoir chamber 16,containing a substance to be delivered, in fluidconnection with a drug administration means18, and an electrically-controlled battery unit 10comprising at least one displacement-generatingbattery cell 19 coupled to the drug reservoirchamber 16 by a coupling means 14, thearrangement being such that the displacementderived from the battery unit 10 is conveyed bythe coupling means 14 to the drug reservoirchamber 16 such that the substance is expelledfrom the drug reservoir chamber 16 towards thedrug administration means 18.US20100280486SYSTEM ANDMETHOD FORDELIVERING ANDMONITORINGMEDICATIONHOSPIRA INC 08/Jun/2009A method of delivering medication to a patientutilizing a medication delivery system isprovided. A first medication to be delivered tothe patient is supplied. The patients identity isverified. The first medication is selected on auser interface to be delivered to the patient. Thevolume of the medication the patient willreceive is entered. The first medication isinjected into the patient through a flow sensorassembly. The flow rate and the volume of thefirst medication delivered to the patient aremonitored by the flow sensor assembly whilethe injection occurs. A visual display providesinformation related to the injection. The methodupdates the patients electronic medicaladministration record to capture the informationregarding the injection of the first medication.
    • Page 54 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comUS20110172609MICRONEEDLECOMPONENTASSEMBLY FORDRUG DELIVERYDEVICEFLUGENINC,RATIO INC08/Jan/2010A device for delivering a drug to a subject isprovided. The device includes a drug reservoir, aconduit coupled to the drug reservoir and amicroneedle component. The microneedlecomponent includes a body, an engagementstructure coupling the microneedle componentto the conduit, a hollow microneedle extendingfrom the body, and a handling feature locatedon the body. The microneedle component isconfigured to be releasably coupled to anassembly tool via the handling feature duringassembly of the device.US20110172645WEARABLE DRUGDELIVERY DEVICEINCLUDINGINTEGRATEDPUMPING ANDACTIVATIONELEMENTSFLUGENINC,RATIO INC08/Jan/2010A drug delivery device for delivering a drug to asubject is provided. The drug delivery deviceincludes a housing, a drug reservoir supportedby the housing containing the drug and a hollowmicroneedle supported by the housing. Thehollow microneedle is moveable from aninactive position to an activated position,wherein, when the hollow microneedle is movedto the activated position, the tip portion of thehollow microneedle is configured to penetratethe skin of the subject. The drug delivery deviceincludes a channel having an input incommunication with the drug reservoir and anoutput in communication with the hollowmicroneedle. The channel provides fluidcommunication between the drug reservoir andthe hollow microneedle, such that the drug ispermitted to flow from the drug reservoirthrough the channel and through the hollowmicroneedle. The channel moves from a firstposition to a second position as the hollowmicroneedle moves from the inactive position tothe activated position, and the position of thedrug reservoir relative to the housing remainsfixed as the hollow microneedle moves from theinactive position to the activated position.US20110270188FILL-STATUSSENSORS FOR DRUGPUMP DEVICESMINIPUMPS LLC 20/Apr/2011The filling status of a drug reservoir in a drugpump devices may be determined withmechanical and/or magnetic position sensorassociated with a reservoir boundary.US20120016299CATHETER DRUGPUMPMINIPUMPS LLC 19/Jul/2011A miniaturized drug pump can actively dispensefluid at a controlled (or controllable) flow rateemerging at or near the distal tip of a catheter.US20120095389ULTRASOUNDCATHETER FORPROVIDING ATHERAPEUTIC EFFECTTO A VESSEL OF ABODYEKOS CORP 21/Dec/2011The invention relates to a catheter system. Thesystem comprises a catheter body having achamber containing a low acoustic impedancemedium. The catheter body includes anelongated body with an external surface and anultrasound transducer having an external sidebetween a first end and a second end. Theultrasound transducer is positioned over theexternal surface of the elongated body such thatthe first end is adjacent to the chamber.
    • Page 55 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comUS5318557Medicationadministering deviceELAN CORP PLC 22/Feb/1993A medication administering device includes ahousing introducible into a body cavity and of amaterial insoluble in the body cavity fluids, butformed with an opening covered by a materialwhich is soluble in body cavity fluids. Adiaphragm divides the interior of the housinginto a medication chamber including theopening, and a control chamber. An electrolyticcell in the control chamber generates a gas whenelectrical current is passed therethrough todeliver medication from the medicationchamber through the opening into the bodycavity at a rate controlled by the electricalcurrent.US5480386Pump assembly formedical useDEBIOTECH SA 06/Jul/1994PCT No. PCT/CH93/00222 Sec. 371 Date Jul. 6,1994 Sec. 102(e) Date Jul. 6, 1994 PCT Filed Sep.14, 1993 PCT Pub. No. WO94/06491 PCT Pub.Date Mar. 31, 1994.A portable pump assemblyfor medical uses, and more particularly aportable micropump designed for the parenteraladministration of medicamentous solutionsincludes a first module (2) provided with acontainer (8) designed for cooperating with asecond motor module (4), the functioning of thepump being ensured by the assembling of thetwo modules. The first module (2) is providedwith a removable filtering and sterilizing device(3), fastened to the filling septum orifice (10) ofthe container and including a filtering sterileplug (25) and a needle (28) surrounded by aflexible sleeve (29). A support arm (33) includesa guiding part (34) for guiding the device (3)when piercing the septurn and an anchoringcasing (40) closing the housing (39) for thesecond module (4). The first module (2) with thedevice (3) is provided in a sterile sealed pouch.The assembly is very easy to use, and asepticconditions are guaranteed during the filling ofthe container (8).US5527288Intradermal drugdelivery device andmethod forintradermal deliveryof drugsELAN CORP PLC 18/Jan/1994An intradermal drug delivery device fordelivering a liquid drug to a subject via thesubjects skin includes a housing having a lowersurface provided with an adhesive coating foradhering the housing to the subjects skin. Anexpansible-contractible chamber within thehousing defines a reservoir which is expandedupon being filled with the drug and contractedto dispense the drug. A hollow needle extendsthrough the lower surface of the housing andhas an inner end which communicates with thereservoir and an outer end which projectsoutwardly of the housing a short distance topenetrate through the epidermis and into thedermis of the subjects skin when the housing isadhered thereto. The device permits delivery ofdrugs of relatively large molecular size and atslow rates which can be precisely controlled. Amethod of delivering a liquid drug intradermallyincludes adhering the intradermal deliverydevice to the skin of the subject and activatingthe means for actively discharging the at leastone drug from the reservoir to the subjects skinvia the needle.
    • Page 56 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comUS5743250Insulin deliveryenhanced bycoached breathingARADIGM CORP 22/Nov/1996The need for the delivery of insulin by injectioncan be reduced or eliminated by a methodwhereby an aerosolized insulin formulation isdelivered to a patients lungs and the rate atwhich the insulin is absorbed into the blood isincreased by the use of an inhale-exhalebreathing maneuver. Particles of insulindelivered to the surface of lung tissue will beabsorbed into the circulatory system. The rate ofabsorption is enhanced by instructing thepatient to inhale maximally and thereafterexhale maximally. This maneuver causes a spikein the rate at which insulin enters the circulatorysystem thereby increasing the rate at whichglucose is removed from the circulatory system.The insulin may be a dry powder but ispreferably in a liquid formulation delivered tothe patient from a hand-held, self-containeddevice which automatically releases anaerosolized burst of formulation. The deviceincludes a sensor which is preferably electronicwhich measures inspiratory flow and volumewhich measurement can be used to control thepoint of drug release. The sensor can also assistthe patient in the inhale-exhale maneuver.US5800420Analyte-controlledliquid delivery deviceand analyte monitorELAN CORP PLC 19/Dec/1996A liquid delivery device comprising a housinghaving a lower surface for application to the skinof a subject and having a reservoir and a gasgeneration chamber therein separated by adisplaceable membrane. Gas generated by anelectrolytic cell under the control of amicroprocessor causes the gas generationchamber to expand and the reservoir tocontract, thereby discharging a liquid drug, suchas insulin, from the reservoir via a hollowdelivery needle extending from the lowersurface. The delivery needle and a sensor needleboth extend from the lower surface a sufficientdistance so as to penetrate through theepidermis and into the dermis when the housingis pressed against the skin. The sensor needlehas an enzymatic coating for the detection of ananalyte, such as glucose in the subjects plasma.The delivery needle is made of platinum-iridium,and a current passes between the needles and apotentiostat circuit according to the amount ofglucose detected. A reference electrode(silver/silver chloride) which rests against thesubjects skin increases the accuracy of theglucose measurement. The current through thepotentiostat circuit is measured by a voltmeterand a signal from the voltmeter is amplified andcommunicated to the microprocessor whichdetermines the correct rate of delivery of thedrug on the basis of the level of analyte detectedin the subjects plasma.
    • Page 57 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comUS5848991Intradermal drugdelivery device andmethod forintradermal deliveryof drugsELAN CORP PLC 25/Apr/1997An intradermal drug delivery device fordelivering a liquid drug to a subject via thesubjects skin includes a housing having a lowersurface provided with an adhesive coating foradhering the housing to the subjects skin. Anexpansible-contractible chamber within thehousing defines a reservoir which is expandedupon being filled with the drug and contractedto dispense the drug. A hollow needle extendsthrough the lower surface of the housing andhas an inner end which communicates with thereservoir and an outer end which projectsoutwardly of the housing a short distance topenetrate through the epidermis and into thedermis of the subjects skin when the housing isadhered thereto. The device permits delivery ofdrugs of relatively large molecular size and atslow rates which can be precisely controlled. Amethod of delivering a liquid drug intradermallyincludes adhering the intradermal deliverydevice to the skin of the subject and activatingthe means for actively discharging the at leastone drug from the reservoir to the subjects skinvia the needle.US5915378Creating anaerosolizedformulation of insulinARADIGM CORP 27/Oct/1995Devices, packaging and methodology forefficiently and repeatably creating aerosolizedbursts of an insulin containing formulation aredisclosed. Devices are hand-held, self-containedunits which are automatically actuated at thesame release point in a patients inspiratory flowcycle. The release point is automaticallydetermined either mechanically or, morepreferably calculated by a microprocessor whichreceives data from a sensor making it possible todetermine inspiratory flow rate and inspiratoryvolume. The device is loaded with a cassettecomprised of an outer housing which holds apackage of individual disposable collapsiblecontainers of an insulin containing formulationfor systemic delivery. Actuation of the deviceforces insulin formulation through a porousmembrane of the container which membranehas pores having a diameter in the range ofabout 0.25 to 3.0 microns, preferably 0.25 to 1.5microns. The porous membrane is positioned inalignment with a surface of a channel throughwhich a patient inhales air. The flow profile of airmoving through the channel is such that the flowat the surface of the channel is less than the flowrate at the center of the channel. The membraneis designed so that it protrudes outward at alltimes or made flexible so that when an insulinformulation is forced against and through themembrane the flexible membrane protrudesoutward beyond the flow boundary layer of thechannel into faster moving air. Because themembrane protrudes into the faster moving airof the channel the particles of aerosol formedare less likely to collide allowing for theformation of a burst of fine aerosol mist withuniform particle size.
    • Page 58 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comUS5970973Method of deliveringinsulin lisproARADIGM CORP 29/Apr/1998The need for the delivery of insulin by injectioncan be reduced or eliminated by a methodwhereby an aerosolized insulin formulation isdelivered to a patients lungs and the rate atwhich the insulin is absorbed into the blood isincreased by the use of monomeric insulinand/or an inhale-exhale breathing maneuver.Particles of insulin and in particular monomericinsulin delivered to the surface of lung tissue willbe absorbed into the circulatory system. Therate of absorption is enhanced by themonomeric form of insulin and by instructing thepatient to inhale maximally and thereafterexhale maximally. This maneuver causes a spikein the rate at which insulin enters the circulatorysystem thereby increasing the rate at whichglucose is removed from the circulatory system.The insulin or insulin analog may be a drypowder but is preferably in a liquid formulationdelivered to the patient from a hand-held, self-contained device which automatically releasesan aerosolized burst of formulation. The deviceincludes a sensor which is preferably electronicwhich measures inspiratory flow and volumewhich measurement can be used to control thepoint of drug release. The sensor can also assistthe patient in the inhale-exhale maneuver.US5997501Intradermal drugdelivery deviceELAN CORP PLC 19/Aug/1996PCT No. PCT/IE94/00055 Sec. 371 Date Aug. 19,1996 Sec. 102(e) Date Aug. 19, 1996 PCT FiledNov. 17, 1994 PCT Pub. No. WO95/13838 PCTPub. Date May 26, 1995An intradermal drugdelivery device comprises a housing (301a, 301b)having a drug reservoir (312) therewithin and agas generation chamber (313) separated fromthe reservoir (312) by a displaceable membrane(311). A microprocessor-controlled electrolyticcell (316a, 316b, 319) provides gas to expand thegas generation chamber (313) and therebycontract the reservoir (312). A hollow needle(310), communicating at an inner end thereofwith the reservoir (312), extends from a lowersurface (308) of the housing (301) such thatcontraction of the reservoir (312) forces drug toescape therefrom via the needle (310). Thedevice permits delivery of drugs of relativelylarge molecular weights at slow controllablerates. A displaceable protective cover (303) ismounted in means (307) allowing movement ofthe cover (303) between extended and retractedpositions (305, 306). The cover (303) has anadhesive lower surface (309) for attachment tothe skin of a subject. In use, a release liner isremoved, the device is pressed against the skinand the cover (303) snaps back to the retractedposition (306), the needle (310) thereby piercingthe skin. After use the housing (301) is pulledaway and the cover (303) snaps to the extendedposition (306) before detaching from the skin,thus concealing the needle (310) beforedisposal.
    • Page 59 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comUS6001069Ultrasound catheterfor providing atherapeutic effect toa vessel of a bodyEKOS CORP 01/May/1998A catheter for use in a vessel of a body isdisclosed. The catheter includes an elongatedbody and a plurality of ultrasound elementscoupled to the elongated body. Each of theplurality of ultrasound elements is separatedfrom an adjacent ultrasound element.US6098620Device foraerosolizing narcoticsARADIGM CORP 27/Oct/1995Devices, packaging and methodology forefficiently and repeatably creating aerosolizedbursts of an analgesic (e.g., narcotic) containingformulation are disclosed. Devices are hand-held, self-contained units which areautomatically actuated at the same release pointin a patients inspiratory flow cycle. The releasepoint is automatically determined eithermechanically or, more preferably calculated by amicroprocessor which receives data from asensor making it possible to determineinspiratory flow rate and inspiratory volume. Thedevice is loaded with a cassette comprised of anouter housing which holds a package ofindividual disposable collapsible containers of ananalgesic containing formulation for systemicdelivery. Actuation of the device forces analgesicformulation through a porous membrane of thecontainer which membrane has pores having adiameter in the range of about 0.25 to 3.0microns, preferably 0.25 to 1.5 microns. Theporous membrane is positioned in alignmentwith a surface of a channel through which apatient inhales air. The flow profile of air movingthrough the channel is such that the flow at thesurface of the channel is less than the flow rateat the center of the channel.US6176842Ultrasound assemblyfor use with lightactivated drugsEKOS CORP 21/Sep/1998A kit and method for causing tissue death withina tissue site is disclosed. The kit includes a mediawith a light activated drug activatable uponexposure to a particular level of ultrasoundenergy. The kit also includes a catheter with alumen coupled with a media delivery portthrough which the light activated drug can belocally delivered to the tissue site. Theultrasound transducer is configured to transmitthe level of ultrasound energy which activatesthe light activated drug with sufficient powerthat the ultrasound energy can penetrate thetissue site.US6427681Method of use ofmonomeric insulin asa means forimproving thereproducibility ofinhaled insulinARADIGM CORP 21/Jun/2001The need for the delivery of insulin by injectioncan be reduced or eliminated by delivering anaerosolized monomeric insulin formulation.Repeatability of dosing and more particularly therepeatability of the blood concentration versustime profile is improved relative to regularinsulin. The blood concentration versus timeprofile is substantially unaffected by specificaspects of the patients breathing maneuver atdelivery. Further, the rate at which bloodglucose is lowered is increased by the use ofmonomeric insulin. Particles of insulin and inparticular monomeric insulin delivered to thesurface of lung tissue will be absorbed into thecirculatory system. The monomeric insulin may
    • Page 60 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.combe a dry powder but is preferably in a liquidformulation delivered to the patient from ahand-held, self-contained device whichautomatically releases an aerosolized burst offormulation. The device includes a sensor whichis preferably electronic which measuresinspiratory flow and volume whichmeasurement can be used to control the pointof drug release.US6723063Sheath for use withan ultrasoundelementEKOS CORP 29/Jun/1998A system for delivering ultrasound energy to atreatment section in a vessel is disclosed. Thesystem includes a sheath with a utility lumenand an energy delivery section at least partiallyconstructed from a material which transmitsultrasound energy. The system also includes adrug delivery member having a plurality of drugdelivery ports which are positioned adjacent theenergy delivery section. The system furtherincludes an elongated body including at leastone ultrasound element and configured to bemovably positioned within the utility lumen totransmit the ultrasound energy from theultrasound element through the energy deliverysection.US6979293Blood flowreestablishmentdeterminationEKOS CORP 16/Dec/2002A method for monitoring a clot dissolutiontreatment in a patients vasculature comprisespositioning a catheter at a treatment site in thepatients vasculature. The method furthercomprises performing a clot dissolutiontreatment at the treatment site. The clotdissolution treatment comprises deliveringultrasonic energy and a therapeutic compoundfrom the catheter to the treatment site such thata clot located at the treatment site at leastpartially dissolves. The method furthercomprises delivering a thermal measurementsignal from a first portion of the catheter to thetreatment site during the clot dissolutiontreatment. The method further comprisesreceiving the thermal measurement signal at asecond portion of the catheter. The methodfurther comprises comparing the deliveredthermal measurement signal with the receivedthermal measurement signal to evaluate a bloodflow rate at the treatment site.US7010340Methods, systems,and associatedimplantable devicesfor dynamicmonitoring ofphysiological andbiological propertiesof tumorsSICELTECHNOLOGIESINC15/Feb/2002Methods of monitoring and evaluating the statusof a tumor undergoing treatment includesmonitoring in vivo at least one physiologicalparameter associated with a tumor in a subjectundergoing treatment, transmitting data froman in situ located sensor to a receiver external ofthe subject, analyzing the transmitted data,repeating the monitoring and transmitting stepsat sequential points in time and evaluating atreatment strategy. The method providesdynamic tracking of the monitored parametersover time. The method can also includeidentifying in a substantially real time mannerwhen conditions are favorable for treatment andwhen conditions are unfavorable for treatmentand can verify or quantify how much of a knowndrug dose or radiation dose was actuallyreceived at the tumor. The method can include
    • Page 61 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comremote transmission from a non-clinical site toallow oversight of the tumors condition evenduring non-active treatment periods (in betweenactive treatments). The disclosure also includesmonitoring systems with in situ in vivobiocompatible sensors and telemetry basedoperations and related computer programproducts.US7311503Micromachinedfluidic device andmethod for makingsameDEBIOTECH SA 26/Sep/2005The fluid-flow device ( 100 ) of the inventioncomprises a stack ( 30 ) covered by a closurewafer ( 20 ), said stack ( 30 ) comprising asupport wafer ( 36 ), a layer of insulatingmaterial ( 34 ), and a silicon layer ( 32 ). Theclosure wafer ( 20 ) and/or said silicon layer ( 32) are machined so as to define a cavity ( 38 )between said closure wafer ( 20 ) and said siliconlayer ( 32 ), said support wafer ( 36 ) has at leastone duct ( 102 ) passing right through it, saidlayer of insulating material ( 34 ) presenting atleast one zone ( 35 ) that is entirely free ofmaterial placed at least in line with said duct (102 ) so as to co-operate with said cavity ( 38 ) todefine a moving member ( 40 ) in said siliconlayer ( 32 ), the moving member being suitableunder the pressure of liquid in said cavity ( 38 )for reversibly moving towards said supportwafer ( 36 ) until contact is made between saidmoving member ( 40 ) and said support wafer (36 ).US7524304 Drug infusion device STEADYMED LTD 29/Jul/2005The invention provides a drug delivery infusiondevice comprising an injection means (18) influid connection with a drug reservoir chamber(12) and pressure-generation means (10)coupled to both the drug reservoir (12) and to aliquid-filled control chamber (13), wherein thecoupling is such that the liquid-filled controlchamber (13) serves to constrain the motion ofthe pressure-generation means (10), therebycontrolling the drug infusion rate, wherein theliquid-filled control chamber (13) is associatedwith means for controlled depletion of the liquidtherein whereby depletion of the volume ofliquid in the control chamber enables thepressure-generation means to drive the drug inthe reservoir chamber therefrom for infusionthereof.US7632228Membrane for usewith implantabledevicesDEXCOM INC 29/Jan/2004The present invention provides a biointerfacemembrane for use with an implantable devicethat interferes with the formation of a barriercell layer including; a first domain distal to theimplantable device wherein the first domainsupports tissue attachment and interferes withbarrier cell layer formation and a second domainproximal to the implantable device wherein thesecond domain is resistant to cellularattachment and is impermeable to cells. Inaddition, the present invention provides sensorsincluding the biointerface membrane,implantable devices including these sensors orbiointerface membranes, and methods ofmonitoring glucose levels in a host utilizing theanalyte detection implantable device of the
    • Page 62 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.cominvention. Other implantable devices whichinclude the biointerface membrane of thepresent invention, such as devices for celltransplantation, drug delivery devices, andelectrical signal delivery or measuring devicesare also provided.US7803148Flow-induceddelivery from a drugmassNEUROSYSTECCORP07/Jun/2007Drug solutions (or other combinations of vehiclewith entrained drug) are prepared by removingdrug from one or more masses of a solid form ofthe drug. The solid form of the drug may besparingly soluble or insoluble in water. Examplesof devices for holding solid drug and facilitatingdelivery of such drug to targeted regions are alsodescribed.US7918843Controllable drugdelivery deviceSTEADYMED LTD 22/Oct/2009A controllable drug delivery device for deliveringa liquid injectable drug, the device comprising adrug reservoir (22), a drug administration device(28), a displacement-generating battery (20),and a current-depletion circuit (85), whereindisplacement generated by the battery ascurrent is depleted from the battery by thecurrent depletion circuit displaces a wall of thedrug reservoir thereby causing the reservoir toexpel liquid injectable drug contained therein viathe drug administration device, and wherein thedrug delivery device further includes a controller(78) that is responsive to a measured parameterindicative of displacement generated by thebattery for applying a variable load (80) acrossthe battery in order to provide a substantiallyconstant-current depletion of the battery andthereby cause the drug delivery device to delivera substantially constant drug delivery rate.US7935104Systems andmethods forsustained medicalinfusion and devicesrelated theretoMEDINGO LTD 03/Apr/2006Embodiments of the invention are directed tosystems, methods and devices for sustainedmedical infusion with controlled rate injection ofa fluid into a body. Such a system may include afirst separate reusable unit, a second separatedepletable unit a third separate disposable unithaving a cannula, and may include a fourthseparate remote control unit. Emission ofappropriate instructions from the fourth unit,when the first unit, the second unit, and thethird unit are coupled together in associativeoperation and disposed on the skin, power issupplied to an engine for generating motion to afluid transfer system, and when the cannula isinserted in the body, fluid is transferred from thereservoir to the body, via the tube and thecannula.
    • Page 63 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comUS7966054Disposable single-useexternal dosimetersfor detectingradiation influoroscopy andother medicalprocedures/therapiesSICELTECHNOLOGIESINC10/Jun/2004Methods, systems, devices, and computerprogram products include positioning single-useradiation sensor patches that have adhesiveonto the skin of a patient to evaluate theradiation dose delivered during a medicalprocedure or treatment session. The sensorpatches are configured to be relativelyunobtrusive and operate during radiationwithout the use of externally extending powercords or lead wires.US7976492Integrated deliverydevice for continuousglucose sensorDEXCOM INC 06/Aug/2009Systems and methods for integrating acontinuous glucose sensor, including a receiver,a medicament delivery device, and optionally asingle point glucose monitor are provided.Manual integrations provide for a physicalassociation between the devices wherein a user(for example, patient or doctor) manually selectsthe amount, type, and/or time of delivery. Semi-automated integration of the devices includesintegrations wherein an operable connectionbetween the integrated components aids theuser (for example, patient or doctor) in selecting,inputting, calculating, or validating the amount,type, or time of medicament delivery of glucosevalues, for example, by transmitting data toanother component and thereby reducing theamount of user input required. Automatedintegration between the devices includesintegrations wherein an operable connectionbetween the integrated components providesfor full control of the system without requireduser interaction.US8328082Medication containerencoding,verification, andidentificationCRISI MEDICALSYSTEMS INC31/May/2011A medication container encoding, verificationand identification method is provided thatincludes receiving data characterizing amedication, generating an identifierencapsulating the data and applying an identifierto a medication container such that it isautomatically readable by a medicationadministration device and/or a medicationwasting device. Related apparatus, systems,methods and articles are also described.WO2007126851DEVICES, SYSTEMSAND METHODS FORMEDICAMENTDELIVERYINTELLIJECT INC 28/Mar/2007An apparatus includes a housing, a medicamentcontainer and an actuator. The apparatusincludes a label configured to be coupled to amedicament delivery device. The label includes afirst surface and a second surface. The firstsurface is configured to be coupled to an outersurface of the medicament delivery device. Thesecond surface includes a textual indicia. Thelabel further includes an electronic circuitsystem configured to output an electronic signal.WO2009053919MEDICAL INJECTIONDEVICE WITHMICRONEEDLESDEBIOTECH SA 23/Oct/2008The present invention relates to a medicalinjection device for delivering medium to apatient comprising at least two microneedles,wherein microneedle tips are arranged with adistance.
    • Page 64 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comWO2009136336MEDICALMICROBUBBLEGENERATIONARTENGA INC 03/May/2009Medical apparatus and processes controllablygenerate medically useful micro or nano bubblesof medically desirable and controllablyselectable size, size distribution, homogeneityand concentration (and/or other key bubbleparameters) for patient infusion, and/or whichmay incorporate therapeutic or other agents forpatient infusion and/or may be combined withtherapeutic or other agents prior to infusion intopatients. The bubble generation apparatus andprocesses controllably permit the adjustmentand selection of key bubble parameters throughbubble generation actuation and orientationtechniques and through selection of bubble fluidcompositions in order to facilitate medicalresearch and/or to optimize treatment forimaging, therapy, sonoporation, inertial andnon-inertial cavitation, and acoustic activation,among other medical uses. Disposable cartridgescontaining such bubbles are provided and mayinclude means for patient infusion.WO2010020891PASSIVE FLUID FLOWREGULATORDEBIOTECH SA 26/Jun/2009A fluid flow regulator (1) of the passive type isdisclosed which has a fluid inlet adapted to beconnected to a fluid reservoir and a fluid outlet(13)adapted to be connected to a patients body.The regulator comprises a rigid substrate (2) anda resilient membrane (3) tightly linked togetherso as to define a cavity (6) there between whichis disconnected to the fluid outlet while themembrane has a first surface (12) opposite thecavity which is connected to the fluid inlet. Themembrane has a plurality of through holes (15)contiguous with the cavity,to define a pathwayfor a fluid from the fluid inlet to the fluid outlet,and is flexible so as to be able to come intocontact with the substrate as a fluid applies asufficient pressure on the first surface. Thethrough holes are arranged such that,when thefluid pressure increases, they close one after theother to increase the regulator fluidic resistanceso that a fluid flow rate would be substantiallyconstant as a function of the pressure applied onthe first surface within a predefined pressurerange.WO2010023666DEVICE ANDMETHOD FORENHANCEDSUBCUTANEOUSINSULINABSORPTIONMEDINGO LTD 27/Aug/2009Products and methods directed to the improvedinfusion of fluids are disclosed. Such productsand methods can be used to more efficiently andefficaciously administer therapeuticpharmaceuticals to a subject in need oftreatment. In many instances, the systemscomprise a therapeutic fluid delivery system anda mechanism for enhancing the absorption ofthe therapeutic fluid.. The enhancement of theabsorption of the therapeutic fluid is generallyperformed locally i.e., at or near the site ofadministration of the therapeutic fluid. Thesystem and methods can be used to deliver anynumber of therapeutic fluids including but notlimited to insulin.
    • Page 65 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comWO2010121103SYSTEM ANDMETHOD FORCONFIGURING ARULE SET FORMEDICAL EVENTMANAGEMENT ANDRESPONSESHOSPIRA INC 16/Apr/2010A system and method to configure a rule setused in connection with a medical monitoringsystem for monitoring patients and patient careequipment, especially medication deliverypumps, based on a variety of conditions andparameters associated with monitored biometricinformation and equipment information and forproviding user-defined responses to thoseconditions and parameters.WO2011028997ADHESIVE SKINPATCH WITH PUMPFOR SUBCUTANEOUSDRUG DELIVERYMINIPUMPSLLC,TAI YU-CHONG03/Sep/2010A drug- delivery device (100) includes a skinpatch (102) with an integral delivery vehicle(106) adherable to a patients skin. An exteriorsurface of the patch defines an envelope withinwhich is disposed a programmable drug pump(114) including a reservoir (110), a cannula (112)for conducting liquid from the reservoir to thedelivery vehicle, and a mechanism for forcingliquid from the reservoir through the cannulaand into the delivery vehicle.WO2012032337A TRANSDERMALDRUGADMINISTRATIONDEVICEOREXO AB 05/Sep/2011A transdermal drug administration devicecomprising a drug delivery element (10) defininga contact surface (12) for location, in use,against a patients skin. The drug deliveryelement (10) includes a sustained-releasepharmaceutical composition. The compositioncomprises a network of a carrier material havinga high mechanical strength and an activepharmaceutical ingredient. The activepharmaceutical ingredient is co-formedlyinterspersed within pores in the solid,continuous network of the carrier material.WO2012061556WEARABLE DRUGDELIVERY DEVICEHAVING SPRINGDRIVE AND SLIDINGACTUATIONMECHANISMFLUGEN INC 03/Nov/2011A drug delivery device is provided. The drugdelivery device includes a drug reservoir in fluidcommunication with a microneedle array. Thedrug delivery device has a sliding actuationmechanism that may be activated by a button orlever. Actuation of the drug delivery deviceinserts the microneedle array into the skin of asubject and causes a piston to compress thedrug reservoir, thereby delivering the drugthrough the microneedle array to the subject.WO2012125695INSTRUMENT ANDMETHODS FORFILLING ANIMPLANTED DRUGPUMPMINIPUMPSLLC,TAI YU-CHONG14/Mar/2012A tool for refilling an implantable pump (100)having at least one reservoir (104). The toolincludes a plurality of independent fluidchannels (212, 214, 216); a fluid reservoir in fluidcommunication with a first one of the fluidchannels; at least one pump fluidly coupled tothe fluid channels, the at least one pump andthe independent fluid channels differing fromeach other in number, wherein (i) a pump isconfigured to apply positive pressure to the firstfluid channel so as to drive fluid from the fluidreservoir therethrough, and (ii) a pump isconfigured to apply negative pressure to thesecond fluid channel; and a connector (210) forremovably connecting the fluid channels to theat least one reservoir.
    • Page 66 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comSummaryDevelopment in microfabrication (micromachining, microelectromechanical systems, MEMS)permits the integration of hard and soft structures, and enables the design of controllablemicrofluidic systems, which is applied to drug delivery. MEMS based microneedles have beenused to deliver a broad range of different low molecular weight drugs, biotherapeutics andvaccines, including published human studies with a number of small-molecule and protein drugsand vaccines. Similarly Micropumps are also extensively used.This report graphically analyzes Miniature Drug Delivery technologies from various perspectives,categorizes and highlights the key and upcoming companies involved.About Patent iNSIGHT ProPatent iNSIGHT Pro™ is a comprehensive patent analysis platform that allows you to accelerateyour time-to-decision from patent analysis activities. Designed from inputs by experiencedpatent researchers, Patent iNSIGHT Pro easily blends into your existing Research workflow.Patent iNSIGHT Pro is used by leading legal services, Pharmaceutical & biotech, electronicscompanies and research organization across US, Europe, South America and India with morethan 400 end users. Patent iNSIGHT Pro is developed and marketed by Gridlogics , a researchdriven IT Company specializing in providing intellectual property analysis and visualizationsolutions to aid R&D and corporate strategy.Gridlogics is headquartered in Pune, India and has a sales presence in Delhi, Mumbai and USA.For more information:Visit us at: www.patentinsightpro.comOr call us at: 1-408-786-5524Or mail us at:Have a comment on this report? Mail us at feedback_tr@patentinsightpro.com
    • Page 67 of 67© 2013 Gridlogics. All Rights Reserved.Patent iNSIGHT Pro™ is a trademark of Gridlogics Technologies Pvt. Ltd.Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.comSources & References1. http://www.sciencedirect.com/science/article/pii/S0169409X120012512. http://scholar.google.com/scholar?start=10&q=miniature+Drug+Delivery&hl=en&as_sdt=0,5&as_vis=13. en.wikipedia.org/wiki/Drug delivery4. PatSeer Patent Database : http://patseer.com