Dr Barry Sears NFL Retired Players

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Dr. Barry Sears discusses inflammation and its direct relationship to concussions. His labs have developed a test for the detection of inflammation and related symptoms of concussion

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Dr Barry Sears NFL Retired Players

  1. 1. Rebuilding Damaged Brains: Implications for A Better Life
  2. 3. Underlying Cause of Chronic Illness <ul><li>Increased Inflammation </li></ul>
  3. 4. What is Inflammation? <ul><li>Ancient Greeks </li></ul><ul><ul><li>Internal Fire </li></ul></ul><ul><li>Ancient Romans </li></ul><ul><ul><li>Heat </li></ul></ul><ul><ul><li>Pain </li></ul></ul><ul><ul><li>Swelling </li></ul></ul><ul><ul><li>Redness </li></ul></ul>
  4. 5. What is Inflammation? <ul><li>Complex orchestration of pro-inflammatory and anti-inflammatory events </li></ul><ul><li>Usually associated with pain </li></ul><ul><li>Mediated by eicosanoids </li></ul><ul><li>Treated by drugs that alter eicosanoids </li></ul><ul><ul><li>Aspirin </li></ul></ul><ul><ul><li>NSAID’s </li></ul></ul><ul><ul><li>COX-2 inhibitors </li></ul></ul><ul><ul><li>Steroids </li></ul></ul>
  5. 6. Events That Turn On Inflammatory Responses <ul><li>Microbial invasion </li></ul><ul><li>Injuries </li></ul><ul><li>Diet </li></ul>
  6. 7. Two Types of Inflammation <ul><li>Screaming Pain </li></ul><ul><ul><li>Organ or joint damage </li></ul></ul><ul><li>Silent Pain </li></ul><ul><ul><li>Cellular inflammation </li></ul></ul>
  7. 8. Measuring Cellular Inflammation <ul><li>High sensitivity C-reactive protein </li></ul><ul><ul><li>Non-specific </li></ul></ul><ul><ul><li>Highly variable due to infection </li></ul></ul><ul><li>AA/EPA Ratio </li></ul><ul><ul><li>Most precise marker of eicosanoid precursors at cellular level </li></ul></ul><ul><ul><li>Highly reliable </li></ul></ul>
  8. 9. Typical AA/EPA Ratios 1.5 Japanese 15 Americans 20 Depression 25 ADHD 40 Brain Trauma
  9. 10. Diseases Associated With Cellular Inflammation <ul><li>Obesity </li></ul><ul><li>Type 2 Diabetes </li></ul><ul><li>Heart Disease </li></ul><ul><li>Cancer </li></ul><ul><li>Alzheimer’s </li></ul><ul><li>ADHD </li></ul><ul><li>Asthma </li></ul><ul><li>Allergies </li></ul><ul><li>Inflammatory conditions (“itis”) </li></ul>
  10. 11. Typical Chronic Conditions In Retired NFL Players <ul><li>Obesity </li></ul><ul><li>Diabetes </li></ul><ul><li>Heart Disease </li></ul><ul><li>Arthritic Pain </li></ul><ul><li>Depression </li></ul><ul><li>ADHD </li></ul><ul><li>Dementia </li></ul>
  11. 12. My Early Days With The NFL <ul><li>Marv Marinovitch </li></ul><ul><li>Garrett Giemont </li></ul><ul><li>Jon Kolb </li></ul>
  12. 13. Improvement of Performance Of NFL Players <ul><li>LA Rams </li></ul><ul><ul><li>Doug Smith </li></ul></ul><ul><ul><li>Lucious Smith </li></ul></ul><ul><li>Pittsburgh Steelers </li></ul><ul><ul><li>Steve Courson </li></ul></ul>
  13. 14. Current NFL Teams We Work With <ul><li>Green Bay Packers </li></ul><ul><li>New York Jets </li></ul><ul><li>San Diego Chargers </li></ul><ul><li>Oakland Raiders </li></ul>
  14. 15. My Early Days with Dr. Dan Amen
  15. 16. Cerebral Blood Flow Can Be Altered By Zone Diet and High Dose Fish Oil <ul><li>Before </li></ul><ul><li>After </li></ul>
  16. 17. Effect of High-Dose Fish Oil on ADHD <ul><li>Improvement is rapid </li></ul><ul><li>Must be continued to maintain benefits </li></ul>Sorgi et al Nutrition J 6:16 (2007)
  17. 18. ADHD Improvement Is Correlated with AA/EPA p =.007 Sorgi et al Nutrition J 6:16 (2007)
  18. 19. SPECT Scan 12-09
  19. 20. Traumatic Brain Injury <ul><li>Leading cause of death and lifelong disability among children and young adults in the United States </li></ul><ul><li>1.5 million Americans survive a traumatic brain injury, among whom approximately 230,000 are hospitalized </li></ul><ul><li>50,000 Americans die each year following traumatic brain injury </li></ul>
  20. 24. Protocol <ul><li>EPA/DHA concentrate (2:1) </li></ul><ul><li>15 grams of EPA and DHA per day </li></ul><ul><li>Measure AA/EPA ratio in the isolated plasma phospholipids weekly to ensure AA/EPA ratio >1.5 </li></ul>
  21. 26. Medical Miracle or High-Dose Fish Oil?
  22. 27. Results to Date 26 M WV Coal miner CO Coma Recovered 40 M TX Firefighter CO Coma Recovered 12 M NY Baseball player Commotio cordis Coma Cardiac arrest Recovered 40 M KY Firefighter CO Coma Recovered 29 M WV Logger CHI Coma Recovered 43 F NY Childbirth Anoxia Coma Recovered 55 F FL Stroke Ischemia Coma Recovered
  23. 28. Is There a Blood Test for Predicting Future Dementia? <ul><li>Group Relative Increase </li></ul><ul><li>In The AA/EPA Ratio </li></ul><ul><li>Normal (n = 19) 1.0 </li></ul><ul><li>Alzheimer’s (n = 19) 1.9 </li></ul><ul><li>Other dementias (n = 10) 1.8 </li></ul><ul><li>Cognitively impaired (n = 36) 1.7 </li></ul><ul><li>Conquer et al. Lipids 35: 1305 (2000) </li></ul>
  24. 29. AA/EPA Ratio Can Change Rapidly In Brain Trauma Patients <ul><li>Pre-Treatment (11-23-10) </li></ul><ul><ul><li>AA/EPA ratio = 41 </li></ul></ul><ul><li>Post-Treatment (1-20-11) </li></ul><ul><ul><li>AA/EPA ratio =3 </li></ul></ul>
  25. 30. Other Neurological Conditions Treated By High-Dose Fish Oil
  26. 31. Bipolar Depression Can Be Treated with High-Dose Fish Oil <ul><li>9.6 grams of n-3 per day </li></ul><ul><li>500% greater remission in 3 months </li></ul><ul><li>Stoll et al Arch Gen Psychiatry 56: 407 (1999) </li></ul>
  27. 32. Multiple Sclerosis Disability Can Be Reversed AA/EPA Disability Status 6 2.2 1.5 1.6* Start 2 Year * p < 0.005 Nordvik et al Acta Neurol Scand 102:143 (2000)
  28. 33. My Most Well Known Parkinson’s Patient
  29. 34. Animal Studies
  30. 35. <ul><li>Weight drop onto steel helmet affixed to skull </li></ul><ul><li>Produces reliable and reproducible injury </li></ul><ul><li>High yield of traumatically injured axons in white matter tracts </li></ul>Impact Acceleration Injury
  31. 36. Omega-3 Blood Levels % Change in omega 3 levels from baseline Miles et al. J Neurosurgery 114: 77 (2011)
  32. 37. AA/EPA Ratio % Change in AA/EPA ratio from baseline Miles et al. J Neurosurgery 114: 77 (2011)
  33. 38. Amyloid Precursor Protein Accumulation in retraction bulbs of morphologically injured axons
  34. 39. Immunohistochemistry Animals subjected to impact acceleration injury demonstrate APP positive axons with retraction bulb morphology at 30 days
  35. 40. Immunohistochemistry Animals subjected to impact acceleration injury and supplemented with 40 mg/kg/day EPA:DHA demonstrate fewer APP positive axons with retraction bulb morphology at 30 days
  36. 41. APP positive axons Axons per high power field
  37. 42. Chronic Disease – What’s Below the Surface Autoimmune Cancer Heart disease Aging Neurological Cellular Inflammation
  38. 43. Summary <ul><li>Cellular inflammation is the underlying cause of neurological disease </li></ul><ul><li>It can be reversed by high-dose fish oil </li></ul><ul><li>Test, don’t guess about how much fish oil you need </li></ul><ul><li>No one is going to help you rebuild your brain except yourself </li></ul>

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