Dr Barry Sears NFL Retired Players

Rebuilding Damaged Brains: Implications for A Better Life

Underlying Cause of Chronic Illness
Increased Inflammation

What is Inflammation?
Ancient Greeks
Internal Fire
Ancient Romans
Heat
Pain
Swelling
Redness

What is Inflammation?
Complex orchestration of pro-inflammatory and anti-inflammatory events
Usually associated with pain
Mediated by eicosanoids
Treated by drugs that alter eicosanoids
Aspirin
NSAID’s
COX-2 inhibitors
Steroids

Events That Turn On Inflammatory Responses
Microbial invasion
Injuries
Diet

Two Types of Inflammation
Screaming Pain
Organ or joint damage
Silent Pain
Cellular inflammation

Measuring Cellular Inflammation
High sensitivity C-reactive protein
Non-specific
Highly variable due to infection
AA/EPA Ratio
Most precise marker of eicosanoid precursors at cellular level
Highly reliable

Typical AA/EPA Ratios 1.5 Japanese 15 Americans 20 Depression 25 ADHD 40 Brain Trauma

Diseases Associated With Cellular Inflammation
Obesity
Type 2 Diabetes
Heart Disease
Cancer
Alzheimer’s
ADHD
Asthma
Allergies
Inflammatory conditions (“itis”)

Typical Chronic Conditions In Retired NFL Players
Obesity
Diabetes
Heart Disease
Arthritic Pain
Depression
ADHD
Dementia

My Early Days With The NFL
Marv Marinovitch
Garrett Giemont
Jon Kolb

Improvement of Performance Of NFL Players
LA Rams
Doug Smith
Lucious Smith
Pittsburgh Steelers
Steve Courson

Current NFL Teams We Work With
Green Bay Packers
New York Jets
San Diego Chargers
Oakland Raiders

My Early Days with Dr. Dan Amen

Cerebral Blood Flow Can Be Altered By Zone Diet and High Dose Fish Oil
Before
After

Effect of High-Dose Fish Oil on ADHD
Improvement is rapid
Must be continued to maintain benefits
Sorgi et al Nutrition J 6:16 (2007)

ADHD Improvement Is Correlated with AA/EPA p =.007 Sorgi et al Nutrition J 6:16 (2007)

SPECT Scan 12-09

Traumatic Brain Injury
Leading cause of death and lifelong disability among children and young adults in the United States
1.5 million Americans survive a traumatic brain injury, among whom approximately 230,000 are hospitalized
50,000 Americans die each year following traumatic brain injury

Protocol
EPA/DHA concentrate (2:1)
15 grams of EPA and DHA per day
Measure AA/EPA ratio in the isolated plasma phospholipids weekly to ensure AA/EPA ratio >1.5

Medical Miracle or High-Dose Fish Oil?

Results to Date 26 M WV Coal miner CO Coma Recovered 40 M TX Firefighter CO Coma Recovered 12 M NY Baseball player Commotio cordis Coma Cardiac arrest Recovered 40 M KY Firefighter CO Coma Recovered 29 M WV Logger CHI Coma Recovered 43 F NY Childbirth Anoxia Coma Recovered 55 F FL Stroke Ischemia Coma Recovered

Is There a Blood Test for Predicting Future Dementia?
Group Relative Increase
In The AA/EPA Ratio
Normal (n = 19) 1.0
Alzheimer’s (n = 19) 1.9
Other dementias (n = 10) 1.8
Cognitively impaired (n = 36) 1.7
Conquer et al. Lipids 35: 1305 (2000)

AA/EPA Ratio Can Change Rapidly In Brain Trauma Patients
Pre-Treatment (11-23-10)
AA/EPA ratio = 41
Post-Treatment (1-20-11)
AA/EPA ratio =3

Other Neurological Conditions Treated By High-Dose Fish Oil

Bipolar Depression Can Be Treated with High-Dose Fish Oil
9.6 grams of n-3 per day
500% greater remission in 3 months
Stoll et al Arch Gen Psychiatry 56: 407 (1999)

Multiple Sclerosis Disability Can Be Reversed AA/EPA Disability Status 6 2.2 1.5 1.6* Start 2 Year * p < 0.005 Nordvik et al Acta Neurol Scand 102:143 (2000)

My Most Well Known Parkinson’s Patient

Animal Studies

Weight drop onto steel helmet affixed to skull
Produces reliable and reproducible injury
High yield of traumatically injured axons in white matter tracts
Impact Acceleration Injury

Omega-3 Blood Levels % Change in omega 3 levels from baseline Miles et al. J Neurosurgery 114: 77 (2011)

AA/EPA Ratio % Change in AA/EPA ratio from baseline Miles et al. J Neurosurgery 114: 77 (2011)

Amyloid Precursor Protein Accumulation in retraction bulbs of morphologically injured axons

Immunohistochemistry Animals subjected to impact acceleration injury demonstrate APP positive axons with retraction bulb morphology at 30 days

Immunohistochemistry Animals subjected to impact acceleration injury and supplemented with 40 mg/kg/day EPA:DHA demonstrate fewer APP positive axons with retraction bulb morphology at 30 days

APP positive axons Axons per high power field

Chronic Disease – What’s Below the Surface Autoimmune Cancer Heart disease Aging Neurological Cellular Inflammation

Summary
Cellular inflammation is the underlying cause of neurological disease
It can be reversed by high-dose fish oil
Test, don’t guess about how much fish oil you need
No one is going to help you rebuild your brain except yourself

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Dr Barry Sears NFL Retired Players

by robertinseattle on Mar 26, 2011

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Dr Barry Sears NFL Retired Players — Presentation Transcript