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Dr Barry Sears NFL Retired Players
 

Dr Barry Sears NFL Retired Players

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Dr. Barry Sears discusses inflammation and its direct relationship to concussions. His labs have developed a test for the detection of inflammation and related symptoms of concussion

Dr. Barry Sears discusses inflammation and its direct relationship to concussions. His labs have developed a test for the detection of inflammation and related symptoms of concussion

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    Dr Barry Sears NFL Retired Players Dr Barry Sears NFL Retired Players Presentation Transcript

    • Rebuilding Damaged Brains: Implications for A Better Life
    •  
    • Underlying Cause of Chronic Illness
      • Increased Inflammation
    • What is Inflammation?
      • Ancient Greeks
        • Internal Fire
      • Ancient Romans
        • Heat
        • Pain
        • Swelling
        • Redness
    • What is Inflammation?
      • Complex orchestration of pro-inflammatory and anti-inflammatory events
      • Usually associated with pain
      • Mediated by eicosanoids
      • Treated by drugs that alter eicosanoids
        • Aspirin
        • NSAID’s
        • COX-2 inhibitors
        • Steroids
    • Events That Turn On Inflammatory Responses
      • Microbial invasion
      • Injuries
      • Diet
    • Two Types of Inflammation
      • Screaming Pain
        • Organ or joint damage
      • Silent Pain
        • Cellular inflammation
    • Measuring Cellular Inflammation
      • High sensitivity C-reactive protein
        • Non-specific
        • Highly variable due to infection
      • AA/EPA Ratio
        • Most precise marker of eicosanoid precursors at cellular level
        • Highly reliable
    • Typical AA/EPA Ratios 1.5 Japanese 15 Americans 20 Depression 25 ADHD 40 Brain Trauma
    • Diseases Associated With Cellular Inflammation
      • Obesity
      • Type 2 Diabetes
      • Heart Disease
      • Cancer
      • Alzheimer’s
      • ADHD
      • Asthma
      • Allergies
      • Inflammatory conditions (“itis”)
    • Typical Chronic Conditions In Retired NFL Players
      • Obesity
      • Diabetes
      • Heart Disease
      • Arthritic Pain
      • Depression
      • ADHD
      • Dementia
    • My Early Days With The NFL
      • Marv Marinovitch
      • Garrett Giemont
      • Jon Kolb
    • Improvement of Performance Of NFL Players
      • LA Rams
        • Doug Smith
        • Lucious Smith
      • Pittsburgh Steelers
        • Steve Courson
    • Current NFL Teams We Work With
      • Green Bay Packers
      • New York Jets
      • San Diego Chargers
      • Oakland Raiders
    • My Early Days with Dr. Dan Amen
    • Cerebral Blood Flow Can Be Altered By Zone Diet and High Dose Fish Oil
      • Before
      • After
    • Effect of High-Dose Fish Oil on ADHD
      • Improvement is rapid
      • Must be continued to maintain benefits
      Sorgi et al Nutrition J 6:16 (2007)
    • ADHD Improvement Is Correlated with AA/EPA p =.007 Sorgi et al Nutrition J 6:16 (2007)
    • SPECT Scan 12-09
    • Traumatic Brain Injury
      • Leading cause of death and lifelong disability among children and young adults in the United States
      • 1.5 million Americans survive a traumatic brain injury, among whom approximately 230,000 are hospitalized
      • 50,000 Americans die each year following traumatic brain injury
    •  
    •  
    •  
    • Protocol
      • EPA/DHA concentrate (2:1)
      • 15 grams of EPA and DHA per day
      • Measure AA/EPA ratio in the isolated plasma phospholipids weekly to ensure AA/EPA ratio >1.5
    •  
    • Medical Miracle or High-Dose Fish Oil?
    • Results to Date 26 M WV Coal miner CO Coma Recovered 40 M TX Firefighter CO Coma Recovered 12 M NY Baseball player Commotio cordis Coma Cardiac arrest Recovered 40 M KY Firefighter CO Coma Recovered 29 M WV Logger CHI Coma Recovered 43 F NY Childbirth Anoxia Coma Recovered 55 F FL Stroke Ischemia Coma Recovered
    • Is There a Blood Test for Predicting Future Dementia?
      • Group Relative Increase
      • In The AA/EPA Ratio
      • Normal (n = 19) 1.0
      • Alzheimer’s (n = 19) 1.9
      • Other dementias (n = 10) 1.8
      • Cognitively impaired (n = 36) 1.7
      • Conquer et al. Lipids 35: 1305 (2000)
    • AA/EPA Ratio Can Change Rapidly In Brain Trauma Patients
      • Pre-Treatment (11-23-10)
        • AA/EPA ratio = 41
      • Post-Treatment (1-20-11)
        • AA/EPA ratio =3
    • Other Neurological Conditions Treated By High-Dose Fish Oil
    • Bipolar Depression Can Be Treated with High-Dose Fish Oil
      • 9.6 grams of n-3 per day
      • 500% greater remission in 3 months
      • Stoll et al Arch Gen Psychiatry 56: 407 (1999)
    • Multiple Sclerosis Disability Can Be Reversed AA/EPA Disability Status 6 2.2 1.5 1.6* Start 2 Year * p < 0.005 Nordvik et al Acta Neurol Scand 102:143 (2000)
    • My Most Well Known Parkinson’s Patient
    • Animal Studies
      • Weight drop onto steel helmet affixed to skull
      • Produces reliable and reproducible injury
      • High yield of traumatically injured axons in white matter tracts
      Impact Acceleration Injury
    • Omega-3 Blood Levels % Change in omega 3 levels from baseline Miles et al. J Neurosurgery 114: 77 (2011)
    • AA/EPA Ratio % Change in AA/EPA ratio from baseline Miles et al. J Neurosurgery 114: 77 (2011)
    • Amyloid Precursor Protein Accumulation in retraction bulbs of morphologically injured axons
    • Immunohistochemistry Animals subjected to impact acceleration injury demonstrate APP positive axons with retraction bulb morphology at 30 days
    • Immunohistochemistry Animals subjected to impact acceleration injury and supplemented with 40 mg/kg/day EPA:DHA demonstrate fewer APP positive axons with retraction bulb morphology at 30 days
    • APP positive axons Axons per high power field
    • Chronic Disease – What’s Below the Surface Autoimmune Cancer Heart disease Aging Neurological Cellular Inflammation
    • Summary
      • Cellular inflammation is the underlying cause of neurological disease
      • It can be reversed by high-dose fish oil
      • Test, don’t guess about how much fish oil you need
      • No one is going to help you rebuild your brain except yourself